Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ASS1-NCS1 (FusionGDB2 ID:HG445TG23413)

Fusion Gene Summary for ASS1-NCS1

check button Fusion gene summary
Fusion gene informationFusion gene name: ASS1-NCS1
Fusion gene ID: hg445tg23413
HgeneTgene
Gene symbol

ASS1

NCS1

Gene ID

445

23413

Gene nameargininosuccinate synthase 1neuronal calcium sensor 1
SynonymsASS|CTLN1FLUP|FREQ
Cytomap('ASS1')('NCS1')

9q34.11

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionargininosuccinate synthaseargininosuccinate synthetase 1citrulline-aspartate ligaseepididymis secretory sperm binding proteinneuronal calcium sensor 1frequenin homologfrequenin-like proteinfrequenin-like ubiquitous protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000493984, ENST00000352480, 
ENST00000372393, ENST00000372394, 
Fusion gene scores* DoF score3 X 5 X 4=606 X 6 X 4=144
# samples 46
** MAII scorelog2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASS1 [Title/Abstract] AND NCS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASS1(133355836)-NCS1(132963237), # samples:2
Anticipated loss of major functional domain due to fusion event.ASS1-NCS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASS1-NCS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASS1

GO:0007623

circadian rhythm

28985504


check buttonFusion gene breakpoints across ASS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NCS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A0A4-01AASS1chr9

133355836

-NCS1chr9

132963237

+
ChimerDB4BRCATCGA-A8-A0A4-01AASS1chr9

133355836

+NCS1chr9

132963237

+


Top

Fusion Gene ORF analysis for ASS1-NCS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000493984ENST00000372398ASS1chr9

133355836

+NCS1chr9

132963237

+
3UTR-3UTRENST00000493984ENST00000458469ASS1chr9

133355836

+NCS1chr9

132963237

+
3UTR-3UTRENST00000493984ENST00000493042ASS1chr9

133355836

+NCS1chr9

132963237

+
5CDS-3UTRENST00000352480ENST00000458469ASS1chr9

133355836

+NCS1chr9

132963237

+
5CDS-3UTRENST00000352480ENST00000493042ASS1chr9

133355836

+NCS1chr9

132963237

+
5CDS-3UTRENST00000372393ENST00000458469ASS1chr9

133355836

+NCS1chr9

132963237

+
5CDS-3UTRENST00000372393ENST00000493042ASS1chr9

133355836

+NCS1chr9

132963237

+
5CDS-3UTRENST00000372394ENST00000458469ASS1chr9

133355836

+NCS1chr9

132963237

+
5CDS-3UTRENST00000372394ENST00000493042ASS1chr9

133355836

+NCS1chr9

132963237

+
In-frameENST00000352480ENST00000372398ASS1chr9

133355836

+NCS1chr9

132963237

+
In-frameENST00000372393ENST00000372398ASS1chr9

133355836

+NCS1chr9

132963237

+
In-frameENST00000372394ENST00000372398ASS1chr9

133355836

+NCS1chr9

132963237

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000352480ASS1chr9133355836+ENST00000372398NCS1chr9132963237+575191091418469
ENST00000372394ASS1chr9133355836+ENST00000372398NCS1chr9132963237+616013192531827524
ENST00000372393ASS1chr9133355836+ENST00000372398NCS1chr9132963237+5754913751421448

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000352480ENST00000372398ASS1chr9133355836+NCS1chr9132963237+0.0018628370.9981371
ENST00000372394ENST00000372398ASS1chr9133355836+NCS1chr9132963237+0.0033940840.9966059
ENST00000372393ENST00000372398ASS1chr9133355836+NCS1chr9132963237+0.0017681410.9982318

Top

Fusion Genomic Features for ASS1-NCS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ASS1chr9133355836+NCS1chr9132963236+0.511007130.48899284
ASS1chr9133355836+NCS1chr9132963236+0.511007130.48899284

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ASS1-NCS1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:133355836/chr9:132963237)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASS1chr9:133355836chr9:132963237ENST00000352480+111510_18279413.0Nucleotide bindingATP
HgeneASS1chr9:133355836chr9:132963237ENST00000352480+1115115_123279413.0Nucleotide bindingATP
HgeneASS1chr9:133355836chr9:132963237ENST00000372393+121610_18279413.0Nucleotide bindingATP
HgeneASS1chr9:133355836chr9:132963237ENST00000372393+1216115_123279413.0Nucleotide bindingATP
HgeneASS1chr9:133355836chr9:132963237ENST00000372394+121610_18279413.0Nucleotide bindingATP
HgeneASS1chr9:133355836chr9:132963237ENST00000372394+1216115_123279413.0Nucleotide bindingATP
TgeneNCS1chr9:133355836chr9:132963237ENST0000037239808109_120211579.3333333333333Calcium binding2
TgeneNCS1chr9:133355836chr9:132963237ENST0000037239808157_168211579.3333333333333Calcium binding3
TgeneNCS1chr9:133355836chr9:132963237ENST000003723980873_84211579.3333333333333Calcium binding1
TgeneNCS1chr9:133355836chr9:132963237ENST0000045846908109_12031605.0Calcium binding2
TgeneNCS1chr9:133355836chr9:132963237ENST0000045846908157_16831605.0Calcium binding3
TgeneNCS1chr9:133355836chr9:132963237ENST000004584690873_8431605.0Calcium binding1
TgeneNCS1chr9:133355836chr9:132963237ENST0000037239808144_179211579.3333333333333DomainEF-hand 4
TgeneNCS1chr9:133355836chr9:132963237ENST000003723980824_59211579.3333333333333DomainEF-hand 1
TgeneNCS1chr9:133355836chr9:132963237ENST000003723980860_95211579.3333333333333DomainEF-hand 2
TgeneNCS1chr9:133355836chr9:132963237ENST000003723980896_131211579.3333333333333DomainEF-hand 3
TgeneNCS1chr9:133355836chr9:132963237ENST0000045846908144_17931605.0DomainEF-hand 4
TgeneNCS1chr9:133355836chr9:132963237ENST000004584690824_5931605.0DomainEF-hand 1
TgeneNCS1chr9:133355836chr9:132963237ENST000004584690860_9531605.0DomainEF-hand 2
TgeneNCS1chr9:133355836chr9:132963237ENST000004584690896_13131605.0DomainEF-hand 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ASS1-NCS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7258_7258_1_ASS1-NCS1_ASS1_chr9_133355836_ENST00000352480_NCS1_chr9_132963237_ENST00000372398_length(transcript)=5751nt_BP=910nt
GCTTATAACCTGGGATGGGCACCCCTGCCAGTCCTGCTCTGCCGCCTGCCACCGCTGCCCGAGCCCGACGCTATGTCCAGCAAAGGCTCC
GTGGTTCTGGCCTACAGTGGCGGCCTGGACACCTCGTGCATCCTCGTGTGGCTGAAGGAACAAGGCTATGACGTCATTGCCTATCTGGCC
AACATTGGCCAGAAGGAAGACTTCGAGGAAGCCAGGAAGAAGGCACTGAAGCTTGGGGCCAAAAAGGTGTTCATTGAGGATGTCAGCAGG
GAGTTTGTGGAGGAGTTCATCTGGCCGGCCATCCAGTCCAGCGCACTGTATGAGGACCGCTACCTCCTGGGCACCTCTCTTGCCAGGCCC
TGCATCGCCCGCAAACAAGTGGAAATCGCCCAGCGGGAGGGGGCCAAGTATGTGTCCCACGGCGCCACAGGAAAGGGGAACGATCAGGTC
CGGTTTGAGCTCAGCTGCTACTCACTGGCCCCCCAGATAAAGGTCATTGCTCCCTGGAGGATGCCTGAATTCTACAACCGGTTCAAGGGC
CGCAATGACCTGATGGAGTACGCAAAGCAACACGGGATTCCCATCCCGGTCACTCCCAAGAACCCGTGGAGCATGGATGAGAACCTCATG
CACATCAGCTACGAGGCTGGAATCCTGGAGAACCCCAAGAACCAAGCGCCTCCAGGTCTCTACACGAAGACCCAGGACCCAGCCAAAGCC
CCCAACACCCCTGACATTCTCGAGATCGAGTTCAAAAAAGGGGTCCCTGTGAAGGTGACCAACGTCAAGGATGGCACCACCCACCAGACC
TCCTTGGAGCTCTTCATGTACCTGAACGAAGTCGCGGGCAAGCATGGCGTGGGCCGTATTGACATCGTGGAGAACCGCTTCATTGGAATG
AAGTCCCGAGTTACCGAGAAGGAGGTCCAGCAGTGGTACAAAGGCTTCATCAAGGACTGCCCCAGTGGGCAGCTGGATGCGGCAGGCTTC
CAGAAGATCTACAAGCAATTCTTCCCGTTCGGAGACCCCACCAAGTTTGCCACATTTGTTTTCAACGTCTTTGATGAAAACAAGGACGGG
CGAATTGAGTTCTCCGAGTTCATCCAGGCGCTGTCGGTGACCTCACGGGGAACCCTGGATGAGAAGCTACGGTGGGCCTTCAAGCTCTAC
GACTTGGACAATGATGGCTACATCACCAGGAATGAGATGCTGGACATTGTGGATGCCATTTACCAGATGGTGGGGAATACCGTGGAGCTC
CCAGAGGAGGAGAACACTCCTGAGAAGAGGGTGGACCGGATCTTTGCCATGATGGATAAGAATGCCGACGGGAAGCTGACCCTGCAGGAG
TTCCAGGAGGGTTCCAAGGCAGACCCGTCCATTGTGCAGGCGCTGTCCCTCTACGACGGGCTGGTATAGTCCCAGGCTGGAGCTGGATGC
CTGGGAACCACTCACCTCCTTCTGTGCCATGAGGCCACCTCAGCCCTGACACCAACCCCGTGCGTCCACCCAGCCTTCTTCCGCATCCAC
ACACAGCCGGCTGCCCTTGACCCGGGAGGCCCCGGCTCTCCTCTCCCCTGTCCTGCACCCATCCCCCGCCTGAAGCCACCGGCTCCAATT
GCCAGCAACCTCTGCTTGTCCGGAAAACGACAACACGAAATGGAAAAGGCTACAGCCCTCTGCATAAACCAAGGACTTGGCTGCCTCGCA
GGCAGCCTCCGTTCCTCCCGCTCTCTTGCGCGTGTGCTTTTGTTTTTTATTTTGAACAGACGTTTTAAAAGAAAAAAAAACAACTACCTT
CTGTCCTAGAAGACACAGACTGACAGATGGGGTGAAGGCCTGGGGACCTCAGAGAACTCTGCCTTGCCCTCGTCCCTCGTCCTTCGGCAG
CCGGAGAGGCTGTGGGTGGGCCGAGGGTGTCTAGGGGTTCTGCCTGGTCAACGTTATTTGTCGTCCCATCTTTTGGCAGCAAAACCACCT
GCGTGGCTAGGATGATTAATTATGAGGATGATGATTTTTTTTGTGATAACAGTATTGTGCTTTTTGTGGGGAAAGTGAGGTTTTTTTTTA
TATACATATATAATTGATATCTTTAATTTATTGGTTGTTAACTGTTGCTGCTGCCTGGTGTGTCCTCAGCTCCCAGGGCTGCGGGCCCAC
CGTTTACATGTGCACGCCCTGACCCACCTGCCCACGCCGACTTGGGAGGATGGTGGCCTGCAGCGGCCAAGAAGCCAAAAAAAATTTTTT
TTTTTTCAGATACTGTGCTTGATTTTTGGAGAGGGGAGAGGTGGAAATTCCTAAATGGCTAATGCACTGTTCCCTCCAGCCCGAATGCCT
CCTGCCAAACCCCTTTTCCCTGCTGCCTCTGTCCCCGCATCCTTGTTCTCCCCTGGGTCCGTAACATTTTTTCCGAGGATGAACAGGGGA
CATCTTTAGGTTTCTCAACTCTTGCTTTGGTGTTTGCCGCAGCATGGAAAACAGGGCGCCTAAGGCTGGGAGCTGGAAGAAGGGGCATTG
GGTACCCAGGCAGAGTCAGGAGAGGTGGTCTTTGAAGTAAGTTAGCAGAAATCAAGGGGACCCCCGCCTCCTTGGGCTGGGGAGGGGATT
TCAAGATAGTTCATGACTCTCTCCCGCTCTGCCTTCCCTCCTTCCTATCTGCTTTTTCCAGTAAACTGCATGGTGTCCTTCCCTGGCCTT
CTCTTGGCTCAAAGGCTGGGAGGGAGGGAAGGAGAGAAGAGTTCCAGGCAATCCCATCAATATAGTCCCTACACCTGGGGCTGCGGCCCA
CATGTCTTCACGGAGGCTTCCAGCGGTGCCTGCCACTGAGGCAGGTGCGGCCCCAGGACCATCACCAGGAATGCGAGGCCACCCTGGACC
AGAGGTAGGAGCCCAAGGTCCGGCCCTTGCTCTTTGATTGTGGGCAGCCTCCTGCCCTCTCTGGGTCTCAGTTGCCCCATCTGCAGAGCG
AGGAGGCCCGGGCTGGTTGGTCTTGAAGGCCCTTTTCCATGCCGACATCATGTCACTCTAGGCCTGGGGTTCAGTTTCCTGTGGCTGGTG
ATGCTGTGGTTAAGTTTGCTTGACCCCAGCAGCCCGAGGGACTGTCTGAGTCACAGCACAGCCCCTATTGCGTGGCTGCTGGTGTGTGGG
GTCAGTTCCAGCAGATGAATGTGTCATGTGGCACACCTTGTCCCTTCCCGCAGCATTTCCTGGTTCCCCCCAGACCCTTGAGCGCTCTTT
GGGACCCAGAAGGAGTCCTTGCACAGGGAAGGCTTGAGGTGAGAAGCCGCTTCCCAGACTGTCAGGGCCAGGCCTGGGTCTAGAATTCTT
GCTGCTGCTTTGCAGAGTCAACAGCCCATCAGCCCATGTTTTAGAGGGGACACTTTGGTCCTCGGTTCCCACCCTCAGCAAGCAGGCCTC
CAGCCCGAGGAAGGCCTCTGCCGTAGTGACGTTGCCGTGTGGGGCTGCGTGGCTGTTCCCCTTGGCTGGAGCATTCAGCCAACCCCAGCG
TCCCCCCTGAGGCGTTCATTGGCAGCCCCCTAGGACTGCACGCTGGCCCCACGGTAACCCCCCCTCCCCCACCAACATCCTGCAGGGATG
GGGTCAGTGGTTCCACCTTCACAGGCCACTTTGAAGGGTGGATTCTTTGAGGCCCCTGCCAGTCGGCTCCCTGCTCAGCTGCTGGCCCGG
GCGACCTGGGACTCAGCACCAACGGCTGAAGTTTCTCAGCTGGGCTCTGACCTGGGGTCTGGGGCAGGGAACGAACATGGTGGCTTTGGG
CTGAGAGGATGAGGGAGGTCTTTCCCAGGTCAAATTACTTTCCTTTGGCCTCTGCCTGAGGCTCGATTTGCCTCTCTGGTCCAATGGGAC
TGACACTGTTGTACAACCTGACCTGTGGCTGAGGGTGTCTGGGCTTAAGCATGTGGACCCCTTCGGTGTGTCCGGCCTTCCTCCATCGTC
CTGCCCTTTGGCCTTTTGGTTTGAAGCCACAGGTGTGGCTTCTGGCCTTAGCAGATGGTATGCTTGCGGACCGCAGCCCAGCATGCCGGT
GGGCCCACAGCCCGAGCCAGCCCAGAGCTGCCGGAAGGGCCGCCCTTCCCGGCCCTGGCGGGGTGCTGGACACTGGCCATTTTCACTAGA
GTTTGCCTGGCAGGGACCGATCTCTGCCCCCTCCTCTCCCCAGGCCTCTGGCTGCAGTGATGCCGCAGAATCCTGAGCCAGGTGCCTCCT
GAGCAGCCCGTGCGCCTCTCCACAGCGGCGTTTGCCACCCAATGCGGCTCGCTTCAGATGCTCTGATGCAGAGGGCACGCCCATAGTCCC
TCTGCAGAGCCTCGCACTGGGGCCAGGGCAGGCACCAGCCCCAGGCGGCCAGTCGGCCACGGCCTGTCCTCTTCCTCGTAGCGTCTGCTC
CTCACTTTGTGTTGATGGTGACTTAGGAGAATGTTCCGATTTTCCATGATCTAAGCAGGCCACGTTTAAAATAACATCAAGGCAAGCGTA
CGTGTCACCCTCTGTACTGACATCTCTTCCCCTGAAATGCTTTTCAGTTTGACAGCCCGTTTCCTAGACAAGTGCACCTGGGGTTTCAGG
AACTTTGTGTTTTTTCGGAGGGGGTTGGTGGGGAGGTCGGGATGCCTGGGATCCCTTCCTGGAGAGGCAGGCTGTCTCTGGAAAAAGCCT
CCATTGCCCACCCGCCAGGCGGAAAGTCACCCTGTTCCCAGCGCGGTTTCAGCATTTAATTTTAAGGGAGCTAAGGAAGCGCGGCGCGCC
CCCTGGTGGTGGTAAGCCGCCAACGCACCTGGGGGCTGCAACCCCACCGGACGGGTGGTCCGGAGGGAGGCTGGAGCGGGGAGGCGAGGA
GGGGGCTGTGAGTCCTCAGAGGCCCTGGGCCACCACATTTCTGGCAGCGTTTCCCAGACACCCCTCTGCTAGGCCATCCCTGGATAGCAA
GTGAATTAACTTAAGGGCACTGTGATGGGAAGCCTTGCCCCCCTCTTTTTTTTTTTTTTTTAATATCTGCGGAATAAACCCAATGGTTAA
TTTTTGAATGAATAAAAGGCTTTTGTTGAATAAACAGCTGGTCCCATCTTCTGTCTTGGCATCTTAGCATCCAGGCTCAGGCTCTGCCCC
TTCTCCAGGATGGGGTAGCCCCGAGTCGCCCTCCCCAGTCTGCACATTCCCTGTTGTCCCTGTTCCTGCAGTGGCTCCCGGCCCCAGGGA
GGCCCACCTCACTCCCAGCCTGACTCGGTGGCTGGCTTCCTTCAGGACTTTGCGCAAGTCAGTTCTGCTCATTGGGTCTCAATTTCCCCA
TCCCTTGGATGGGAGCAAGAGTCTCTGCTGGGCCTGCCTCGCAGGGGCCTGGTGAGACCCAAATGTGAGTGTCATCATCAAAGCCCCTCA
CAGAAGTGGAGGACGGTGCCCAAGAGTAGCGGTTTGGACTGCTGCTGCCTCCCACCCGGAGCCTGCCACTTGGGGGAGAAATTGGTATAA
TGCTTGCAAAAACAAACAAACAAAAGGCAATGTCTTCTGGTTGTGGTTATTTCCTTTCCTGCTTGCCTCCCCAGCCCCCTTTGAGTCTCT
TTTTGGGGTGCCGTCCTGTCTGAACCTGCCGGTGTGTGTCTCTGGGGCCAGGGTCAGGGCGAGGCCCAGGGGTGGACAGGGGCCGTGTAG
CATGCCCCAGCCTCCCCAAGCTCCTGCTGTATGTCGTCCATGTCACGCCAATTAAACACGCTTCCTGGACTTGTCCTCGCC

>7258_7258_1_ASS1-NCS1_ASS1_chr9_133355836_ENST00000352480_NCS1_chr9_132963237_ENST00000372398_length(amino acids)=469AA_BP=300
MGWAPLPVLLCRLPPLPEPDAMSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSREFV
EEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRND
LMEYAKQHGIPIPVTPKNPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKDGTTHQTSLE
LFMYLNEVAGKHGVGRIDIVENRFIGMKSRVTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIE
FSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQE
GSKADPSIVQALSLYDGLV

--------------------------------------------------------------
>7258_7258_2_ASS1-NCS1_ASS1_chr9_133355836_ENST00000372393_NCS1_chr9_132963237_ENST00000372398_length(transcript)=5754nt_BP=913nt
CGAGCCCGAGTGGTTCACTGCACTGTGAAAACAGATTCCAGACGCCGGGAACTCACGCCTCCAATCCCAGACGCTATGTCCAGCAAAGGC
TCCGTGGTTCTGGCCTACAGTGGCGGCCTGGACACCTCGTGCATCCTCGTGTGGCTGAAGGAACAAGGCTATGACGTCATTGCCTATCTG
GCCAACATTGGCCAGAAGGAAGACTTCGAGGAAGCCAGGAAGAAGGCACTGAAGCTTGGGGCCAAAAAGGTGTTCATTGAGGATGTCAGC
AGGGAGTTTGTGGAGGAGTTCATCTGGCCGGCCATCCAGTCCAGCGCACTGTATGAGGACCGCTACCTCCTGGGCACCTCTCTTGCCAGG
CCCTGCATCGCCCGCAAACAAGTGGAAATCGCCCAGCGGGAGGGGGCCAAGTATGTGTCCCACGGCGCCACAGGAAAGGGGAACGATCAG
GTCCGGTTTGAGCTCAGCTGCTACTCACTGGCCCCCCAGATAAAGGTCATTGCTCCCTGGAGGATGCCTGAATTCTACAACCGGTTCAAG
GGCCGCAATGACCTGATGGAGTACGCAAAGCAACACGGGATTCCCATCCCGGTCACTCCCAAGAACCCGTGGAGCATGGATGAGAACCTC
ATGCACATCAGCTACGAGGCTGGAATCCTGGAGAACCCCAAGAACCAAGCGCCTCCAGGTCTCTACACGAAGACCCAGGACCCAGCCAAA
GCCCCCAACACCCCTGACATTCTCGAGATCGAGTTCAAAAAAGGGGTCCCTGTGAAGGTGACCAACGTCAAGGATGGCACCACCCACCAG
ACCTCCTTGGAGCTCTTCATGTACCTGAACGAAGTCGCGGGCAAGCATGGCGTGGGCCGTATTGACATCGTGGAGAACCGCTTCATTGGA
ATGAAGTCCCGAGTTACCGAGAAGGAGGTCCAGCAGTGGTACAAAGGCTTCATCAAGGACTGCCCCAGTGGGCAGCTGGATGCGGCAGGC
TTCCAGAAGATCTACAAGCAATTCTTCCCGTTCGGAGACCCCACCAAGTTTGCCACATTTGTTTTCAACGTCTTTGATGAAAACAAGGAC
GGGCGAATTGAGTTCTCCGAGTTCATCCAGGCGCTGTCGGTGACCTCACGGGGAACCCTGGATGAGAAGCTACGGTGGGCCTTCAAGCTC
TACGACTTGGACAATGATGGCTACATCACCAGGAATGAGATGCTGGACATTGTGGATGCCATTTACCAGATGGTGGGGAATACCGTGGAG
CTCCCAGAGGAGGAGAACACTCCTGAGAAGAGGGTGGACCGGATCTTTGCCATGATGGATAAGAATGCCGACGGGAAGCTGACCCTGCAG
GAGTTCCAGGAGGGTTCCAAGGCAGACCCGTCCATTGTGCAGGCGCTGTCCCTCTACGACGGGCTGGTATAGTCCCAGGCTGGAGCTGGA
TGCCTGGGAACCACTCACCTCCTTCTGTGCCATGAGGCCACCTCAGCCCTGACACCAACCCCGTGCGTCCACCCAGCCTTCTTCCGCATC
CACACACAGCCGGCTGCCCTTGACCCGGGAGGCCCCGGCTCTCCTCTCCCCTGTCCTGCACCCATCCCCCGCCTGAAGCCACCGGCTCCA
ATTGCCAGCAACCTCTGCTTGTCCGGAAAACGACAACACGAAATGGAAAAGGCTACAGCCCTCTGCATAAACCAAGGACTTGGCTGCCTC
GCAGGCAGCCTCCGTTCCTCCCGCTCTCTTGCGCGTGTGCTTTTGTTTTTTATTTTGAACAGACGTTTTAAAAGAAAAAAAAACAACTAC
CTTCTGTCCTAGAAGACACAGACTGACAGATGGGGTGAAGGCCTGGGGACCTCAGAGAACTCTGCCTTGCCCTCGTCCCTCGTCCTTCGG
CAGCCGGAGAGGCTGTGGGTGGGCCGAGGGTGTCTAGGGGTTCTGCCTGGTCAACGTTATTTGTCGTCCCATCTTTTGGCAGCAAAACCA
CCTGCGTGGCTAGGATGATTAATTATGAGGATGATGATTTTTTTTGTGATAACAGTATTGTGCTTTTTGTGGGGAAAGTGAGGTTTTTTT
TTATATACATATATAATTGATATCTTTAATTTATTGGTTGTTAACTGTTGCTGCTGCCTGGTGTGTCCTCAGCTCCCAGGGCTGCGGGCC
CACCGTTTACATGTGCACGCCCTGACCCACCTGCCCACGCCGACTTGGGAGGATGGTGGCCTGCAGCGGCCAAGAAGCCAAAAAAAATTT
TTTTTTTTTCAGATACTGTGCTTGATTTTTGGAGAGGGGAGAGGTGGAAATTCCTAAATGGCTAATGCACTGTTCCCTCCAGCCCGAATG
CCTCCTGCCAAACCCCTTTTCCCTGCTGCCTCTGTCCCCGCATCCTTGTTCTCCCCTGGGTCCGTAACATTTTTTCCGAGGATGAACAGG
GGACATCTTTAGGTTTCTCAACTCTTGCTTTGGTGTTTGCCGCAGCATGGAAAACAGGGCGCCTAAGGCTGGGAGCTGGAAGAAGGGGCA
TTGGGTACCCAGGCAGAGTCAGGAGAGGTGGTCTTTGAAGTAAGTTAGCAGAAATCAAGGGGACCCCCGCCTCCTTGGGCTGGGGAGGGG
ATTTCAAGATAGTTCATGACTCTCTCCCGCTCTGCCTTCCCTCCTTCCTATCTGCTTTTTCCAGTAAACTGCATGGTGTCCTTCCCTGGC
CTTCTCTTGGCTCAAAGGCTGGGAGGGAGGGAAGGAGAGAAGAGTTCCAGGCAATCCCATCAATATAGTCCCTACACCTGGGGCTGCGGC
CCACATGTCTTCACGGAGGCTTCCAGCGGTGCCTGCCACTGAGGCAGGTGCGGCCCCAGGACCATCACCAGGAATGCGAGGCCACCCTGG
ACCAGAGGTAGGAGCCCAAGGTCCGGCCCTTGCTCTTTGATTGTGGGCAGCCTCCTGCCCTCTCTGGGTCTCAGTTGCCCCATCTGCAGA
GCGAGGAGGCCCGGGCTGGTTGGTCTTGAAGGCCCTTTTCCATGCCGACATCATGTCACTCTAGGCCTGGGGTTCAGTTTCCTGTGGCTG
GTGATGCTGTGGTTAAGTTTGCTTGACCCCAGCAGCCCGAGGGACTGTCTGAGTCACAGCACAGCCCCTATTGCGTGGCTGCTGGTGTGT
GGGGTCAGTTCCAGCAGATGAATGTGTCATGTGGCACACCTTGTCCCTTCCCGCAGCATTTCCTGGTTCCCCCCAGACCCTTGAGCGCTC
TTTGGGACCCAGAAGGAGTCCTTGCACAGGGAAGGCTTGAGGTGAGAAGCCGCTTCCCAGACTGTCAGGGCCAGGCCTGGGTCTAGAATT
CTTGCTGCTGCTTTGCAGAGTCAACAGCCCATCAGCCCATGTTTTAGAGGGGACACTTTGGTCCTCGGTTCCCACCCTCAGCAAGCAGGC
CTCCAGCCCGAGGAAGGCCTCTGCCGTAGTGACGTTGCCGTGTGGGGCTGCGTGGCTGTTCCCCTTGGCTGGAGCATTCAGCCAACCCCA
GCGTCCCCCCTGAGGCGTTCATTGGCAGCCCCCTAGGACTGCACGCTGGCCCCACGGTAACCCCCCCTCCCCCACCAACATCCTGCAGGG
ATGGGGTCAGTGGTTCCACCTTCACAGGCCACTTTGAAGGGTGGATTCTTTGAGGCCCCTGCCAGTCGGCTCCCTGCTCAGCTGCTGGCC
CGGGCGACCTGGGACTCAGCACCAACGGCTGAAGTTTCTCAGCTGGGCTCTGACCTGGGGTCTGGGGCAGGGAACGAACATGGTGGCTTT
GGGCTGAGAGGATGAGGGAGGTCTTTCCCAGGTCAAATTACTTTCCTTTGGCCTCTGCCTGAGGCTCGATTTGCCTCTCTGGTCCAATGG
GACTGACACTGTTGTACAACCTGACCTGTGGCTGAGGGTGTCTGGGCTTAAGCATGTGGACCCCTTCGGTGTGTCCGGCCTTCCTCCATC
GTCCTGCCCTTTGGCCTTTTGGTTTGAAGCCACAGGTGTGGCTTCTGGCCTTAGCAGATGGTATGCTTGCGGACCGCAGCCCAGCATGCC
GGTGGGCCCACAGCCCGAGCCAGCCCAGAGCTGCCGGAAGGGCCGCCCTTCCCGGCCCTGGCGGGGTGCTGGACACTGGCCATTTTCACT
AGAGTTTGCCTGGCAGGGACCGATCTCTGCCCCCTCCTCTCCCCAGGCCTCTGGCTGCAGTGATGCCGCAGAATCCTGAGCCAGGTGCCT
CCTGAGCAGCCCGTGCGCCTCTCCACAGCGGCGTTTGCCACCCAATGCGGCTCGCTTCAGATGCTCTGATGCAGAGGGCACGCCCATAGT
CCCTCTGCAGAGCCTCGCACTGGGGCCAGGGCAGGCACCAGCCCCAGGCGGCCAGTCGGCCACGGCCTGTCCTCTTCCTCGTAGCGTCTG
CTCCTCACTTTGTGTTGATGGTGACTTAGGAGAATGTTCCGATTTTCCATGATCTAAGCAGGCCACGTTTAAAATAACATCAAGGCAAGC
GTACGTGTCACCCTCTGTACTGACATCTCTTCCCCTGAAATGCTTTTCAGTTTGACAGCCCGTTTCCTAGACAAGTGCACCTGGGGTTTC
AGGAACTTTGTGTTTTTTCGGAGGGGGTTGGTGGGGAGGTCGGGATGCCTGGGATCCCTTCCTGGAGAGGCAGGCTGTCTCTGGAAAAAG
CCTCCATTGCCCACCCGCCAGGCGGAAAGTCACCCTGTTCCCAGCGCGGTTTCAGCATTTAATTTTAAGGGAGCTAAGGAAGCGCGGCGC
GCCCCCTGGTGGTGGTAAGCCGCCAACGCACCTGGGGGCTGCAACCCCACCGGACGGGTGGTCCGGAGGGAGGCTGGAGCGGGGAGGCGA
GGAGGGGGCTGTGAGTCCTCAGAGGCCCTGGGCCACCACATTTCTGGCAGCGTTTCCCAGACACCCCTCTGCTAGGCCATCCCTGGATAG
CAAGTGAATTAACTTAAGGGCACTGTGATGGGAAGCCTTGCCCCCCTCTTTTTTTTTTTTTTTTAATATCTGCGGAATAAACCCAATGGT
TAATTTTTGAATGAATAAAAGGCTTTTGTTGAATAAACAGCTGGTCCCATCTTCTGTCTTGGCATCTTAGCATCCAGGCTCAGGCTCTGC
CCCTTCTCCAGGATGGGGTAGCCCCGAGTCGCCCTCCCCAGTCTGCACATTCCCTGTTGTCCCTGTTCCTGCAGTGGCTCCCGGCCCCAG
GGAGGCCCACCTCACTCCCAGCCTGACTCGGTGGCTGGCTTCCTTCAGGACTTTGCGCAAGTCAGTTCTGCTCATTGGGTCTCAATTTCC
CCATCCCTTGGATGGGAGCAAGAGTCTCTGCTGGGCCTGCCTCGCAGGGGCCTGGTGAGACCCAAATGTGAGTGTCATCATCAAAGCCCC
TCACAGAAGTGGAGGACGGTGCCCAAGAGTAGCGGTTTGGACTGCTGCTGCCTCCCACCCGGAGCCTGCCACTTGGGGGAGAAATTGGTA
TAATGCTTGCAAAAACAAACAAACAAAAGGCAATGTCTTCTGGTTGTGGTTATTTCCTTTCCTGCTTGCCTCCCCAGCCCCCTTTGAGTC
TCTTTTTGGGGTGCCGTCCTGTCTGAACCTGCCGGTGTGTGTCTCTGGGGCCAGGGTCAGGGCGAGGCCCAGGGGTGGACAGGGGCCGTG
TAGCATGCCCCAGCCTCCCCAAGCTCCTGCTGTATGTCGTCCATGTCACGCCAATTAAACACGCTTCCTGGACTTGTCCTCGCC

>7258_7258_2_ASS1-NCS1_ASS1_chr9_133355836_ENST00000372393_NCS1_chr9_132963237_ENST00000372398_length(amino acids)=448AA_BP=279
MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSREFVEEFIWPAIQSSALYEDRYLLG
TSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWS
MDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKDGTTHQTSLELFMYLNEVAGKHGVGRIDIVE
NRFIGMKSRVTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLR
WAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDGLV

--------------------------------------------------------------
>7258_7258_3_ASS1-NCS1_ASS1_chr9_133355836_ENST00000372394_NCS1_chr9_132963237_ENST00000372398_length(transcript)=6160nt_BP=1319nt
CTGCTCTGCCGCCTGCCACCGCTGCCCGAGCCCGGTGGGCGGCGGCACTGCGTGCTGGGGAAGCACAGATTCTTGTGCCCTCTGTGACCT
TGAGCCTGCCACTGACCTCTCTGAGCCCTGCTGGCTGCCTCCCCAATAGGAATGACAACTCCTACTTCATGAGGTTGTAGTGGGGGCTCA
GGGGCACAGGGAGATCCCGCTGAGGCTCCCAGGGCCCTGCCTGGTGCTTGGCAAGGAGCAGTTCTGATGGGGGATGTGTCAGCTGCCAGA
GGCTCAGAGCCAAGGCCCCTCCCACATCTCCTGCCTGCGTGCATTCCTCACATCCTGGCCTTGGGCCAAACTGCTCAGCCTCAGCCGCCT
TCCCTCGATGCTGGAGGATCAGGTCCAAGAGATGCCTCTCCCCGACCAGCCTAGGACTGCAGTCAGCATTCCCAGGCCCCAGTGTGGTCT
GTGGGGCTGTGTGCAGAGTGTGCGAGACGCTATGTCCAGCAAAGGCTCCGTGGTTCTGGCCTACAGTGGCGGCCTGGACACCTCGTGCAT
CCTCGTGTGGCTGAAGGAACAAGGCTATGACGTCATTGCCTATCTGGCCAACATTGGCCAGAAGGAAGACTTCGAGGAAGCCAGGAAGAA
GGCACTGAAGCTTGGGGCCAAAAAGGTGTTCATTGAGGATGTCAGCAGGGAGTTTGTGGAGGAGTTCATCTGGCCGGCCATCCAGTCCAG
CGCACTGTATGAGGACCGCTACCTCCTGGGCACCTCTCTTGCCAGGCCCTGCATCGCCCGCAAACAAGTGGAAATCGCCCAGCGGGAGGG
GGCCAAGTATGTGTCCCACGGCGCCACAGGAAAGGGGAACGATCAGGTCCGGTTTGAGCTCAGCTGCTACTCACTGGCCCCCCAGATAAA
GGTCATTGCTCCCTGGAGGATGCCTGAATTCTACAACCGGTTCAAGGGCCGCAATGACCTGATGGAGTACGCAAAGCAACACGGGATTCC
CATCCCGGTCACTCCCAAGAACCCGTGGAGCATGGATGAGAACCTCATGCACATCAGCTACGAGGCTGGAATCCTGGAGAACCCCAAGAA
CCAAGCGCCTCCAGGTCTCTACACGAAGACCCAGGACCCAGCCAAAGCCCCCAACACCCCTGACATTCTCGAGATCGAGTTCAAAAAAGG
GGTCCCTGTGAAGGTGACCAACGTCAAGGATGGCACCACCCACCAGACCTCCTTGGAGCTCTTCATGTACCTGAACGAAGTCGCGGGCAA
GCATGGCGTGGGCCGTATTGACATCGTGGAGAACCGCTTCATTGGAATGAAGTCCCGAGTTACCGAGAAGGAGGTCCAGCAGTGGTACAA
AGGCTTCATCAAGGACTGCCCCAGTGGGCAGCTGGATGCGGCAGGCTTCCAGAAGATCTACAAGCAATTCTTCCCGTTCGGAGACCCCAC
CAAGTTTGCCACATTTGTTTTCAACGTCTTTGATGAAAACAAGGACGGGCGAATTGAGTTCTCCGAGTTCATCCAGGCGCTGTCGGTGAC
CTCACGGGGAACCCTGGATGAGAAGCTACGGTGGGCCTTCAAGCTCTACGACTTGGACAATGATGGCTACATCACCAGGAATGAGATGCT
GGACATTGTGGATGCCATTTACCAGATGGTGGGGAATACCGTGGAGCTCCCAGAGGAGGAGAACACTCCTGAGAAGAGGGTGGACCGGAT
CTTTGCCATGATGGATAAGAATGCCGACGGGAAGCTGACCCTGCAGGAGTTCCAGGAGGGTTCCAAGGCAGACCCGTCCATTGTGCAGGC
GCTGTCCCTCTACGACGGGCTGGTATAGTCCCAGGCTGGAGCTGGATGCCTGGGAACCACTCACCTCCTTCTGTGCCATGAGGCCACCTC
AGCCCTGACACCAACCCCGTGCGTCCACCCAGCCTTCTTCCGCATCCACACACAGCCGGCTGCCCTTGACCCGGGAGGCCCCGGCTCTCC
TCTCCCCTGTCCTGCACCCATCCCCCGCCTGAAGCCACCGGCTCCAATTGCCAGCAACCTCTGCTTGTCCGGAAAACGACAACACGAAAT
GGAAAAGGCTACAGCCCTCTGCATAAACCAAGGACTTGGCTGCCTCGCAGGCAGCCTCCGTTCCTCCCGCTCTCTTGCGCGTGTGCTTTT
GTTTTTTATTTTGAACAGACGTTTTAAAAGAAAAAAAAACAACTACCTTCTGTCCTAGAAGACACAGACTGACAGATGGGGTGAAGGCCT
GGGGACCTCAGAGAACTCTGCCTTGCCCTCGTCCCTCGTCCTTCGGCAGCCGGAGAGGCTGTGGGTGGGCCGAGGGTGTCTAGGGGTTCT
GCCTGGTCAACGTTATTTGTCGTCCCATCTTTTGGCAGCAAAACCACCTGCGTGGCTAGGATGATTAATTATGAGGATGATGATTTTTTT
TGTGATAACAGTATTGTGCTTTTTGTGGGGAAAGTGAGGTTTTTTTTTATATACATATATAATTGATATCTTTAATTTATTGGTTGTTAA
CTGTTGCTGCTGCCTGGTGTGTCCTCAGCTCCCAGGGCTGCGGGCCCACCGTTTACATGTGCACGCCCTGACCCACCTGCCCACGCCGAC
TTGGGAGGATGGTGGCCTGCAGCGGCCAAGAAGCCAAAAAAAATTTTTTTTTTTTCAGATACTGTGCTTGATTTTTGGAGAGGGGAGAGG
TGGAAATTCCTAAATGGCTAATGCACTGTTCCCTCCAGCCCGAATGCCTCCTGCCAAACCCCTTTTCCCTGCTGCCTCTGTCCCCGCATC
CTTGTTCTCCCCTGGGTCCGTAACATTTTTTCCGAGGATGAACAGGGGACATCTTTAGGTTTCTCAACTCTTGCTTTGGTGTTTGCCGCA
GCATGGAAAACAGGGCGCCTAAGGCTGGGAGCTGGAAGAAGGGGCATTGGGTACCCAGGCAGAGTCAGGAGAGGTGGTCTTTGAAGTAAG
TTAGCAGAAATCAAGGGGACCCCCGCCTCCTTGGGCTGGGGAGGGGATTTCAAGATAGTTCATGACTCTCTCCCGCTCTGCCTTCCCTCC
TTCCTATCTGCTTTTTCCAGTAAACTGCATGGTGTCCTTCCCTGGCCTTCTCTTGGCTCAAAGGCTGGGAGGGAGGGAAGGAGAGAAGAG
TTCCAGGCAATCCCATCAATATAGTCCCTACACCTGGGGCTGCGGCCCACATGTCTTCACGGAGGCTTCCAGCGGTGCCTGCCACTGAGG
CAGGTGCGGCCCCAGGACCATCACCAGGAATGCGAGGCCACCCTGGACCAGAGGTAGGAGCCCAAGGTCCGGCCCTTGCTCTTTGATTGT
GGGCAGCCTCCTGCCCTCTCTGGGTCTCAGTTGCCCCATCTGCAGAGCGAGGAGGCCCGGGCTGGTTGGTCTTGAAGGCCCTTTTCCATG
CCGACATCATGTCACTCTAGGCCTGGGGTTCAGTTTCCTGTGGCTGGTGATGCTGTGGTTAAGTTTGCTTGACCCCAGCAGCCCGAGGGA
CTGTCTGAGTCACAGCACAGCCCCTATTGCGTGGCTGCTGGTGTGTGGGGTCAGTTCCAGCAGATGAATGTGTCATGTGGCACACCTTGT
CCCTTCCCGCAGCATTTCCTGGTTCCCCCCAGACCCTTGAGCGCTCTTTGGGACCCAGAAGGAGTCCTTGCACAGGGAAGGCTTGAGGTG
AGAAGCCGCTTCCCAGACTGTCAGGGCCAGGCCTGGGTCTAGAATTCTTGCTGCTGCTTTGCAGAGTCAACAGCCCATCAGCCCATGTTT
TAGAGGGGACACTTTGGTCCTCGGTTCCCACCCTCAGCAAGCAGGCCTCCAGCCCGAGGAAGGCCTCTGCCGTAGTGACGTTGCCGTGTG
GGGCTGCGTGGCTGTTCCCCTTGGCTGGAGCATTCAGCCAACCCCAGCGTCCCCCCTGAGGCGTTCATTGGCAGCCCCCTAGGACTGCAC
GCTGGCCCCACGGTAACCCCCCCTCCCCCACCAACATCCTGCAGGGATGGGGTCAGTGGTTCCACCTTCACAGGCCACTTTGAAGGGTGG
ATTCTTTGAGGCCCCTGCCAGTCGGCTCCCTGCTCAGCTGCTGGCCCGGGCGACCTGGGACTCAGCACCAACGGCTGAAGTTTCTCAGCT
GGGCTCTGACCTGGGGTCTGGGGCAGGGAACGAACATGGTGGCTTTGGGCTGAGAGGATGAGGGAGGTCTTTCCCAGGTCAAATTACTTT
CCTTTGGCCTCTGCCTGAGGCTCGATTTGCCTCTCTGGTCCAATGGGACTGACACTGTTGTACAACCTGACCTGTGGCTGAGGGTGTCTG
GGCTTAAGCATGTGGACCCCTTCGGTGTGTCCGGCCTTCCTCCATCGTCCTGCCCTTTGGCCTTTTGGTTTGAAGCCACAGGTGTGGCTT
CTGGCCTTAGCAGATGGTATGCTTGCGGACCGCAGCCCAGCATGCCGGTGGGCCCACAGCCCGAGCCAGCCCAGAGCTGCCGGAAGGGCC
GCCCTTCCCGGCCCTGGCGGGGTGCTGGACACTGGCCATTTTCACTAGAGTTTGCCTGGCAGGGACCGATCTCTGCCCCCTCCTCTCCCC
AGGCCTCTGGCTGCAGTGATGCCGCAGAATCCTGAGCCAGGTGCCTCCTGAGCAGCCCGTGCGCCTCTCCACAGCGGCGTTTGCCACCCA
ATGCGGCTCGCTTCAGATGCTCTGATGCAGAGGGCACGCCCATAGTCCCTCTGCAGAGCCTCGCACTGGGGCCAGGGCAGGCACCAGCCC
CAGGCGGCCAGTCGGCCACGGCCTGTCCTCTTCCTCGTAGCGTCTGCTCCTCACTTTGTGTTGATGGTGACTTAGGAGAATGTTCCGATT
TTCCATGATCTAAGCAGGCCACGTTTAAAATAACATCAAGGCAAGCGTACGTGTCACCCTCTGTACTGACATCTCTTCCCCTGAAATGCT
TTTCAGTTTGACAGCCCGTTTCCTAGACAAGTGCACCTGGGGTTTCAGGAACTTTGTGTTTTTTCGGAGGGGGTTGGTGGGGAGGTCGGG
ATGCCTGGGATCCCTTCCTGGAGAGGCAGGCTGTCTCTGGAAAAAGCCTCCATTGCCCACCCGCCAGGCGGAAAGTCACCCTGTTCCCAG
CGCGGTTTCAGCATTTAATTTTAAGGGAGCTAAGGAAGCGCGGCGCGCCCCCTGGTGGTGGTAAGCCGCCAACGCACCTGGGGGCTGCAA
CCCCACCGGACGGGTGGTCCGGAGGGAGGCTGGAGCGGGGAGGCGAGGAGGGGGCTGTGAGTCCTCAGAGGCCCTGGGCCACCACATTTC
TGGCAGCGTTTCCCAGACACCCCTCTGCTAGGCCATCCCTGGATAGCAAGTGAATTAACTTAAGGGCACTGTGATGGGAAGCCTTGCCCC
CCTCTTTTTTTTTTTTTTTTAATATCTGCGGAATAAACCCAATGGTTAATTTTTGAATGAATAAAAGGCTTTTGTTGAATAAACAGCTGG
TCCCATCTTCTGTCTTGGCATCTTAGCATCCAGGCTCAGGCTCTGCCCCTTCTCCAGGATGGGGTAGCCCCGAGTCGCCCTCCCCAGTCT
GCACATTCCCTGTTGTCCCTGTTCCTGCAGTGGCTCCCGGCCCCAGGGAGGCCCACCTCACTCCCAGCCTGACTCGGTGGCTGGCTTCCT
TCAGGACTTTGCGCAAGTCAGTTCTGCTCATTGGGTCTCAATTTCCCCATCCCTTGGATGGGAGCAAGAGTCTCTGCTGGGCCTGCCTCG
CAGGGGCCTGGTGAGACCCAAATGTGAGTGTCATCATCAAAGCCCCTCACAGAAGTGGAGGACGGTGCCCAAGAGTAGCGGTTTGGACTG
CTGCTGCCTCCCACCCGGAGCCTGCCACTTGGGGGAGAAATTGGTATAATGCTTGCAAAAACAAACAAACAAAAGGCAATGTCTTCTGGT
TGTGGTTATTTCCTTTCCTGCTTGCCTCCCCAGCCCCCTTTGAGTCTCTTTTTGGGGTGCCGTCCTGTCTGAACCTGCCGGTGTGTGTCT
CTGGGGCCAGGGTCAGGGCGAGGCCCAGGGGTGGACAGGGGCCGTGTAGCATGCCCCAGCCTCCCCAAGCTCCTGCTGTATGTCGTCCAT
GTCACGCCAATTAAACACGCTTCCTGGACTTGTCCTCGCC

>7258_7258_3_ASS1-NCS1_ASS1_chr9_133355836_ENST00000372394_NCS1_chr9_132963237_ENST00000372398_length(amino acids)=524AA_BP=355
MCQLPEAQSQGPSHISCLRAFLTSWPWAKLLSLSRLPSMLEDQVQEMPLPDQPRTAVSIPRPQCGLWGCVQSVRDAMSSKGSVVLAYSGG
LDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVE
IAQREGAKYVSHGATGKGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWSMDENLMHISYEAGI
LENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKDGTTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRVTEKE
VQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYI
TRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDGLV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ASS1-NCS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneNCS1chr9:133355836chr9:132963237ENST0000037239808174_19021.3333333333333321579.3333333333333IL1RAPL1
TgeneNCS1chr9:133355836chr9:132963237ENST0000045846908174_1903.33333333333333351605.0IL1RAPL1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ASS1-NCS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ASS1-NCS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASS1C4721769Citrullinemia Type 122CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneASS1C0175683Citrullinemia10CLINGEN;CTD_human;GENOMICS_ENGLAND
HgeneASS1C0751751Argininosuccinic Acid Synthetase Deficiency, Complete9CLINGEN;CTD_human
HgeneASS1C0011875Diabetic Angiopathies1CTD_human
HgeneASS1C0025945Microangiopathy, Diabetic1CTD_human
HgeneASS1C3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneC0005586Bipolar Disorder2PSYGENET
TgeneC0036341Schizophrenia2PSYGENET
TgeneC0600427Cocaine Dependence1PSYGENET