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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ATF1-FUS (FusionGDB2 ID:HG466TG2521) |
Fusion Gene Summary for ATF1-FUS |
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Fusion gene information | Fusion gene name: ATF1-FUS | Fusion gene ID: hg466tg2521 | Hgene | Tgene | Gene symbol | ATF1 | FUS | Gene ID | 466 | 2521 |
Gene name | activating transcription factor 1 | FUS RNA binding protein | |
Synonyms | EWS-ATF1|FUS/ATF-1|TREB36 | ALS6|ETM4|FUS1|HNRNPP2|POMP75|TLS | |
Cytomap | ('ATF1')('FUS') 12q13.12 | 16p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | cyclic AMP-dependent transcription factor ATF-1cAMP-dependent transcription factor ATF-1 | RNA-binding protein FUS75 kDa DNA-pairing proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in liposarcoma protein | |
Modification date | 20200315 | 20200329 | |
UniProtAcc | P18846 | P35637 | |
Ensembl transtripts involved in fusion gene | ENST00000262053, ENST00000539132, | ENST00000539132, ENST00000262053, | |
Fusion gene scores | * DoF score | 8 X 7 X 6=336 | 20 X 13 X 10=2600 |
# samples | 7 | 22 | |
** MAII score | log2(7/336*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(22/2600*10)=-3.56293619439116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ATF1 [Title/Abstract] AND FUS [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | |||
Anticipated loss of major functional domain due to fusion event. | FUS-ATF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FUS-ATF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ATF1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 1655749 |
Tgene | FUS | GO:0006355 | regulation of transcription, DNA-templated | 26124092 |
Tgene | FUS | GO:0006357 | regulation of transcription by RNA polymerase II | 25453086 |
Tgene | FUS | GO:0008380 | RNA splicing | 26124092 |
Tgene | FUS | GO:0043484 | regulation of RNA splicing | 25453086|27731383 |
Tgene | FUS | GO:0048255 | mRNA stabilization | 27378374 |
Tgene | FUS | GO:0051260 | protein homooligomerization | 25453086 |
Tgene | FUS | GO:1905168 | positive regulation of double-strand break repair via homologous recombination | 10567410 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerKB3 | . | . | ATF1 | chr5 | 37834747 | - | FUS | chr16 | 31200443 | + |
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Fusion Gene ORF analysis for ATF1-FUS |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000262053 | ENST00000254108 | ATF1 | chr5 | 37834747 | - | FUS | chr16 | 31200443 | + |
intron-3CDS | ENST00000262053 | ENST00000380244 | ATF1 | chr5 | 37834747 | - | FUS | chr16 | 31200443 | + |
intron-3CDS | ENST00000262053 | ENST00000568685 | ATF1 | chr5 | 37834747 | - | FUS | chr16 | 31200443 | + |
intron-3CDS | ENST00000539132 | ENST00000254108 | ATF1 | chr5 | 37834747 | - | FUS | chr16 | 31200443 | + |
intron-3CDS | ENST00000539132 | ENST00000380244 | ATF1 | chr5 | 37834747 | - | FUS | chr16 | 31200443 | + |
intron-3CDS | ENST00000539132 | ENST00000568685 | ATF1 | chr5 | 37834747 | - | FUS | chr16 | 31200443 | + |
intron-3UTR | ENST00000262053 | ENST00000474990 | ATF1 | chr5 | 37834747 | - | FUS | chr16 | 31200443 | + |
intron-3UTR | ENST00000539132 | ENST00000474990 | ATF1 | chr5 | 37834747 | - | FUS | chr16 | 31200443 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ATF1-FUS |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ATF1-FUS |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ATF1 | FUS |
FUNCTION: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}. | FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ATF1-FUS |
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Fusion Gene PPI Analysis for ATF1-FUS |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ATF1-FUS |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ATF1-FUS |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ATF1 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Hgene | ATF1 | C0206651 | Clear Cell Sarcoma of Soft Tissue | 1 | ORPHANET |
Hgene | ATF1 | C1136382 | Sclerocystic Ovaries | 1 | CTD_human |
Tgene | C1842675 | AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) | 5 | UNIPROT | |
Tgene | C3468114 | Juvenile amyotrophic lateral sclerosis | 5 | ORPHANET | |
Tgene | C0002736 | Amyotrophic Lateral Sclerosis | 2 | CTD_human;ORPHANET | |
Tgene | C0206634 | Liposarcoma, Myxoid | 2 | CTD_human;ORPHANET | |
Tgene | C0393554 | Amyotrophic Lateral Sclerosis With Dementia | 1 | CTD_human | |
Tgene | C0497327 | Dementia | 1 | GENOMICS_ENGLAND | |
Tgene | C0543859 | Amyotrophic Lateral Sclerosis, Guam Form | 1 | CTD_human | |
Tgene | C3539195 | TREMOR, HEREDITARY ESSENTIAL, 4 | 1 | CTD_human;UNIPROT | |
Tgene | C3888102 | Frontotemporal Dementia With Motor Neuron Disease | 1 | ORPHANET |