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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACO1-ARL3 (FusionGDB2 ID:HG48TG403)

Fusion Gene Summary for ACO1-ARL3

check button Fusion gene summary
Fusion gene informationFusion gene name: ACO1-ARL3
Fusion gene ID: hg48tg403
HgeneTgene
Gene symbol

ACO1

ARL3

Gene ID

48

403

Gene nameaconitase 1ADP ribosylation factor like GTPase 3
SynonymsACONS|HEL60|IREB1|IREBP|IREBP1|IRP1ARFL3|JBTS35|RP83
Cytomap('ACO1')('ARL3')

9p21.1

10q24.32

Type of geneprotein-codingprotein-coding
Descriptioncytoplasmic aconitate hydrataseaconitase 1, solubleaconitate hydratase, cytoplasmiccitrate hydro-lyasecytoplasmic aconitasecytosplasmic aconitaseepididymis luminal protein 60epididymis secretory sperm binding proteinferritin repressor proteinironADP-ribosylation factor-like protein 3ADP-ribosylation factor-like 3ARF-like 3
Modification date2020031320200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000309951, ENST00000379923, 
ENST00000541043, 
ENST00000309951, 
ENST00000379923, ENST00000541043, 
Fusion gene scores* DoF score4 X 4 X 4=647 X 5 X 5=175
# samples 67
** MAII scorelog2(6/64*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACO1 [Title/Abstract] AND ARL3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACO1(32436395)-ARL3(104445758), # samples:2
Anticipated loss of major functional domain due to fusion event.ACO1-ARL3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACO1-ARL3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACO1-ARL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACO1-ARL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARL3-ACO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARL3-ACO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACO1

GO:0006101

citrate metabolic process

8041788|16527810

HgeneACO1

GO:0010040

response to iron(II) ion

8041788

TgeneARL3

GO:0007264

small GTPase mediated signal transduction

22085962


check buttonFusion gene breakpoints across ACO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ARL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-D1-A175-01AACO1chr9

32436395

+ARL3chr10

104445758

-
ChimerDB4UCECTCGA-D1-A175ACO1chr9

32436395

+ARL3chr10

104445758

-


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Fusion Gene ORF analysis for ACO1-ARL3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000309951ENST00000260746ACO1chr9

32436395

+ARL3chr10

104445758

-
In-frameENST00000379923ENST00000260746ACO1chr9

32436395

+ARL3chr10

104445758

-
In-frameENST00000541043ENST00000260746ACO1chr9

32436395

+ARL3chr10

104445758

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000541043ACO1chr932436395+ENST00000260746ARL3chr10104445758-585024531492686845
ENST00000379923ACO1chr932436395+ENST00000260746ARL3chr10104445758-585024531492686845
ENST00000309951ACO1chr932436395+ENST00000260746ARL3chr10104445758-57822385332618861

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541043ENST00000260746ACO1chr932436395+ARL3chr10104445758-0.0011785040.99882144
ENST00000379923ENST00000260746ACO1chr932436395+ARL3chr10104445758-0.0011785040.99882144
ENST00000309951ENST00000260746ACO1chr932436395+ARL3chr10104445758-0.0012395160.99876046

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Fusion Genomic Features for ACO1-ARL3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ACO1-ARL3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:32436395/chr10:104445758)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACO1chr9:32436395chr10:104445758ENST00000309951+1821205_207749890.0RegionSubstrate binding
HgeneACO1chr9:32436395chr10:104445758ENST00000379923+1922205_207749890.0RegionSubstrate binding
TgeneARL3chr9:32436395chr10:104445758ENST0000026074636126_129105183.0Nucleotide bindingGTP
TgeneARL3chr9:32436395chr10:104445758ENST0000026074636159_161105183.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACO1chr9:32436395chr10:104445758ENST00000309951+1821779_780749890.0RegionSubstrate binding
HgeneACO1chr9:32436395chr10:104445758ENST00000379923+1922779_780749890.0RegionSubstrate binding
TgeneARL3chr9:32436395chr10:104445758ENST000002607463624_31105183.0Nucleotide bindingGTP
TgeneARL3chr9:32436395chr10:104445758ENST000002607463667_71105183.0Nucleotide bindingGTP


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Fusion Gene Sequence for ACO1-ARL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1336_1336_1_ACO1-ARL3_ACO1_chr9_32436395_ENST00000309951_ARL3_chr10_104445758_ENST00000260746_length(transcript)=5782nt_BP=2385nt
GGGGCGAGAGGGGGCGGAGCGTGGAGGCGGCAGCTGGAACCGCGCAGCGCACGGGAACGCGTCCCGCTGCTTGGGTCAGGTTCGCCGGTC
GCGGGAGCCCCGCCGTGCAGTCGGAGGAACACGTGGCCATCAGTAATCATGAGCAACCCATTCGCACACCTTGCTGAGCCATTGGATCCT
GTACAACCAGGAAAGAAATTCTTCAATTTGAATAAATTGGAGGATTCAAGATATGGGCGCTTACCATTTTCGATCAGAGTTCTTCTGGAA
GCAGCCATTCGGAATTGTGATGAGTTTTTGGTGAAGAAACAGGATATTGAAAATATTCTACATTGGAATGTCACGCAGCACAAGAACATA
GAAGTGCCATTTAAGCCTGCTCGTGTCATCCTGCAGGACTTTACGGGTGTGCCCGCTGTGGTTGACTTTGCTGCAATGCGTGATGCTGTG
AAAAAGTTAGGAGGAGATCCAGAGAAAATAAACCCTGTCTGCCCTGCTGATCTTGTAATAGATCATTCCATCCAGGTTGATTTCAACAGA
AGGGCAGACAGTTTACAGAAGAATCAAGACCTGGAATTTGAAAGAAATAGAGAGCGATTTGAATTTTTAAAGTGGGGTTCCCAGGCTTTT
CACAACATGCGGATTATTCCCCCTGGCTCAGGAATCATCCACCAGGTGAATTTGGAATATTTGGCAAGAGTGGTATTTGATCAGGATGGA
TATTATTACCCAGACAGCCTCGTGGGCACAGACTCGCACACTACCATGATTGATGGCTTGGGCATTCTTGGTTGGGGTGTCGGTGGTATT
GAAGCAGAAGCTGTCATGCTGGGTCAGCCAATCAGTATGGTGCTTCCTCAGGTGATTGGCTACAGGCTGATGGGGAAGCCCCACCCTCTG
GTAACATCCACTGACATCGTGCTCACCATTACCAAGCACCTCCGCCAGGTTGGGGTAGTGGGCAAATTTGTCGAGTTCTTCGGGCCTGGA
GTAGCCCAGTTGTCCATTGCTGACCGAGCTACGATTGCTAACATGTGTCCAGAGTACGGAGCAACTGCTGCCTTTTTCCCAGTTGATGAA
GTTAGTATCACGTACCTGGTGCAAACAGGTCGTGATGAAGAAAAATTAAAGTATATTAAAAAATATCTTCAGGCTGTAGGAATGTTTCGA
GATTTCAATGACCCTTCTCAAGACCCAGACTTCACCCAGGTTGTGGAATTAGATTTGAAAACAGTAGTGCCTTGCTGTAGTGGACCCAAA
AGGCCTCAGGACAAAGTTGCTGTGTCCGACATGAAAAAGGACTTTGAGAGCTGCCTTGGAGCCAAGCAAGGATTTAAAGGATTCCAAGTT
GCTCCTGAACATCATAATGACCATAAGACCTTTATCTATGATAACACTGAATTCACCCTTGCTCATGGTTCTGTGGTCATTGCTGCCATT
ACTAGCTGCACAAACACCAGTAATCCGTCTGTGATGTTAGGGGCAGGATTGTTAGCAAAGAAAGCTGTGGATGCTGGCCTGAACGTGATG
CCTTACATCAAAACTAGCCTGTCTCCTGGGAGTGGCGTGGTCACCTACTACCTACAAGAAAGCGGAGTCATGCCTTATCTGTCTCAGCTT
GGGTTTGACGTGGTGGGCTATGGCTGCATGACCTGCATTGGCAACAGTGGGCCTTTACCTGAACCTGTGGTAGAAGCCATCACACAGGGA
GACCTTGTAGCTGTTGGAGTACTATCTGGAAACAGGAATTTTGAAGGTCGAGTTCACCCCAACACCCGGGCCAACTATTTAGCCTCTCCC
CCCTTAGTAATAGCATATGCAATTGCTGGAACCATCAGAATCGACTTTGAGAAAGAGCCATTGGGAGTAAATGCAAAGGGACAGCAGGTA
TTTCTGAAAGATATCTGGCCGACTAGAGACGAGATCCAGGCAGTGGAGCGTCAGTATGTCATCCCGGGGATGTTTAAGGAAGTCTATCAG
AAAATAGAGACTGTGAATGAAAGCTGGAATGCCTTAGCAACCCCATCAGATAAGCTGTTTTTCTGGAATTCCAAATCTACGTATATCAAA
TCACCACCATTCTTTGAAAACCTGACTTTGGATCTTCAGCCCCCTAAATCTATAGTGGATGCCTATGTGCTGCTAAATTTGGGAGATTCG
GTAACAACTGACCACATCTCCCCAGCTGGAAATATTGCAAGAAACAGTCCTGCTGCTCGCTACTTAACTAACAGAGGCCTAACTCCACGA
GAATTCAACTCCTATGGCTCCCGCCGAGGTAATGACGCCGTCATGGCACGGGGAACATTTGCCAACATTCGCTTGTTAAACAGATTTTTG
AACAAGCAGGCACCACAGACTATCCATCTGCCTTCTGGGGAAATCGAACTAGCGGAATTACTGGAGGAAGAAAAACTAAGTTGTGTGCCA
GTGCTCATCTTTGCTAATAAGCAGGATTTGCTCACAGCAGCCCCTGCCTCTGAAATTGCAGAAGGACTGAACCTGCATACCATCCGCGAC
CGAGTCTGGCAGATCCAGTCTTGCTCAGCTCTCACAGGAGAGGGCGTTCAGGATGGCATGAACTGGGTCTGCAAAAATGTCAATGCAAAG
AAGAAATAAAATCTAGACGAATGGAGATGCAGGAGCTGCGGGAGCCGAATTCGGTCCTGAAAAACACTAATTTGCTGCTTTCTGACCAAA
TGTTTTTCCATCTGTGTACAGCTCCAGCTGTTTGAAGAGAGGGAACAACACGGTTTAGAAAGAATCCCCATTCCAGCAGTAGATTTAACT
GATCTCTGAGGTTCAGTATCATTTTTCAAATAAAGGAATTATATTATTTCCTCTGCATAATTGAAATAGTATTAAATGTCTCAAAGCACA
TGATTAGAAAATGAGATCTTTTAAATGAGCAAGAGATTGCATTGCAGTTTAGACAATTCCAGTGGGCTTTTTTTTCCTCTCAAAAAAAAA
AAAAGAAAAAGAAAAAGAGGAAGAAGCAGCTTTGCTGAGTTCATTTATTTACTGACCCGTCCCTTGCATTCCCTCCATGGTTTTGAAACC
ACAGACAGTGTTTGCTGGTGCTGTCAGTGATTTTTACCGTCACTAGCCCAGCCAGGCTTCAGTCTGTCCGACAGGAAGCTGCTGGGTGGG
GGTGGGGGGAGAAAAGGCAGATAATTAAACCATCTCATCGTCTTGCAGGTCGGAGACTACGTATGTAATCCTCACTCTTTGGACAGAAAA
AAAAAAAAAAGTCTTTCTTGCAGACAAGTCACTACAGAAACATACCCCATCCCACCCACCCCTGCCTCTGCCCCAGCCAGCCACACAGAG
AAGCAAATTCTTATGACTTTTGACTGTAATGACATCTGGAATGTAAGGAGAGGTGGGAGGTTTAATTCCAGAAAAATTACAAGGTCCTTA
AAAAGCTCTCACATCGAGGGCTCAGGCTAGCGTAAACAGGCTTTCTCCAGCTCAGTGGAGCAGTGAGCAGCCGACTCTGAGATTAGCTGG
CTTCTCCACGGCCGTCCTATAGACAGGATTTCTAAAGCTCAAAGAATTCTGTGTTTAAACGATCACAATAGGCCGCTGCTATCAGATTTT
AGAAATAAATGCAGCTTTACCATGAACCTGCTCCACTGAGAAAAGCCAGGCAGATCGATTTTTAGATCAATTTTTACAGTGCTGGCAACT
TGGTGGTGTGGGATGCTCCTGGATGGAGAGGGTTTGCTGCTGGGGAGGACATGGGTGTGTGTGTGACTGCAGGGGTCGTGTCCAAGGAAT
CAAGAGTCACCCCAGCTGCTGGGCTCCTCTGCCTCTCTGCAGCAGAATGTCCGTCCTCTGTTGATTGATTGGAGAGGAATAGCAGAACAT
TTCTCCTGCCCCTCGTTGCAAAACGAGCTTGTTTCCCTGAACCTCAGAAATCCTCAGCTTCAAACATGGGGAAACAGGCCAGAGCATTGC
CCGGCTCCTGAATTAAACTCTGTTCTGGTGCCTGAGCTCAGGGGTTTTCAGAGAATGAATAAGAGACTGTCCAGTGACTGGTGGGTCCCT
GGGGGCCAGCTGCCTTCTCATCCTGGGAGGTGGCCCTTCCCAAGCCCATCAGGGCGTGTGAGCAGACTGAAGGGGCCGCTGCAGCCCCTG
GCCCTCAATACCCAGCTGCTTCTGGCTAAGAGTGCAGCAGAGACTGAGGCATAGCCAGCTTCAAAAGCGATCTGACATGAAAGTCATTAA
CAAAGCCAGCCGTGAAAAGGTGCCCCAGAGTTGCTGTGGACAGACCTGTAAGGACTTGCAAAACAAAAGAAAGTGAGGGGTTTTTTTAAC
CTCAGAGCTAGCTGCTCTCTGCAGCCTCCTCCACTGGCTTCTCTGGCTCACCCAAGCTCTCCCTTACAGAGGCAACACAGAATTATAAGG
AATCAGAAATCCCCCTTCTACCAGGCTGCAAATGTGGCTCTAGCACTTGCAAATTGTTTTTTCTTCCGAATAGTTCAGCAGGGACAAGTT
ATCTGAGGGGCAAAATGCCTGCTTGGAGGTCTGCAATTTTGGAACACTGCAGTATGGAACTTTGGCATTGGAGGGTCTGTAAAATATTTT
TGTTCTTTTACCACCAACTTAGGGGACTGTTTTAAAGAGCCATCCCAAGGCCTCTCCTAGCAGGCAGAAGCCACTCCTCTGATAACGGCC
TCTGTAAATGTTCTGATTTGCTCTCAGCTGCAGAGACACAGAGACACTGCAGATGTCACACGCTTTCATCTTCCCTTTGAGCCCTTTTGA
ACCCTCCTGGGGCTCTGGGGTAGATGAGAGAAGCCTGAAAAAGGCAGAGTTTGAAAGCTCCCATTTAAAAACAAAATACTTTTTAAAGCC
CTCTTGCCTCTTCCCTGCCCACTCCTGCCCCCTGACCAGAAGACAGAATTTGAAGCTGGAAAGGGAAGACCCCTTTTCCCCTCCTCCTGT
CCCCAGTGAGTCTTAGCGAGACTTTTGCCCTGCGCACAATTGCATCTGAATGTGCGGGGGAGAGGGCTGGGGGCCGGAGGGCAGGCAAGG
CCTGGGGGGTGCTCGTGATATGTGCTCAAGCCAGTTGTGGGAAAAACTCGAGTCCTCCCCTCCTCCCGACCTACCCCGTGTGGCTGCTTT
TGGCTGGATTCCCTGCACCCAGTGCAACACACCCTTTCCCCTTCACTCTCCCTTGGTTACTATGGAAACAAGGGTGTCATTGATGTGGGC
TGAGCTGGGGAACATGTCGGTGCACAGCTGAAAGTCAGCGATTATGCCGGCGGTTAGAAATGTGCCAGGGTTAAAGGAGTCCGCAGCTCC
CACGGCTGCTGGGAGGACATGGTCCTGCCCCCTTCCTTCCTCCCTCCCTCCGTCTCCACTTCTCTCTCCTTGCTTTTGACAAATTTCTTT
ATTCCCCTCTGGACTAAAGTAGTGGCTATTTTTGTGCCACTCTGCGCCCCACCCTCACTGTTGGCCGCTCCTTATCCGGCCTGGCCTGGA
GGGTGACACCATGTCACCCTCACCAGGACTCGTCTCTCCATTCCCGTCAGAGTTTGCTTTGATTTCCCTTTCCTTTCCTTCTCGGGGACC
AGTTCTTACTTCCTTTTATTTTTAGCTCTGCACTCCATGTGGTTTCAGGGTTCAGTCTGATCCATCAAAAGGTTCTTTTTTTATAATCCC
TTTTGAAAATGATAATCAAAGGAAGAGATGTGGTGTTTGGTCATGTGGAAAACTCAATGTATAATTTAGACGTCTGTCAAAAATCCGACA

>1336_1336_1_ACO1-ARL3_ACO1_chr9_32436395_ENST00000309951_ARL3_chr10_104445758_ENST00000260746_length(amino acids)=861AA_BP=784
MEPRSARERVPLLGSGSPVAGAPPCSRRNTWPSVIMSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLV
KKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDL
EFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPI
SMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGR
DEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTF
IYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMT
CIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDE
IQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGN
IARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEIELAELLEEEKLSCVPVLIFANKQDLL

--------------------------------------------------------------
>1336_1336_2_ACO1-ARL3_ACO1_chr9_32436395_ENST00000379923_ARL3_chr10_104445758_ENST00000260746_length(transcript)=5850nt_BP=2453nt
GGGGCGAGAGGGGGCGGAGCGTGGAGGCGGCAGCTGGAACCGCGCAGCGCACGGGAACGCGTCCCGCTGCTTGGGTCAGGTTCGCCGGTC
GCGGGAGCCCCGCCGTGCAGTCGGAGAGGGTGTCACTCTGAGTGGTGCTTCCTCAGCCCCTGTCAAAAAGCAGTTTCCACCATCCTGGAG
TGTGGAACACGTGGCCATCAGTAATCATGAGCAACCCATTCGCACACCTTGCTGAGCCATTGGATCCTGTACAACCAGGAAAGAAATTCT
TCAATTTGAATAAATTGGAGGATTCAAGATATGGGCGCTTACCATTTTCGATCAGAGTTCTTCTGGAAGCAGCCATTCGGAATTGTGATG
AGTTTTTGGTGAAGAAACAGGATATTGAAAATATTCTACATTGGAATGTCACGCAGCACAAGAACATAGAAGTGCCATTTAAGCCTGCTC
GTGTCATCCTGCAGGACTTTACGGGTGTGCCCGCTGTGGTTGACTTTGCTGCAATGCGTGATGCTGTGAAAAAGTTAGGAGGAGATCCAG
AGAAAATAAACCCTGTCTGCCCTGCTGATCTTGTAATAGATCATTCCATCCAGGTTGATTTCAACAGAAGGGCAGACAGTTTACAGAAGA
ATCAAGACCTGGAATTTGAAAGAAATAGAGAGCGATTTGAATTTTTAAAGTGGGGTTCCCAGGCTTTTCACAACATGCGGATTATTCCCC
CTGGCTCAGGAATCATCCACCAGGTGAATTTGGAATATTTGGCAAGAGTGGTATTTGATCAGGATGGATATTATTACCCAGACAGCCTCG
TGGGCACAGACTCGCACACTACCATGATTGATGGCTTGGGCATTCTTGGTTGGGGTGTCGGTGGTATTGAAGCAGAAGCTGTCATGCTGG
GTCAGCCAATCAGTATGGTGCTTCCTCAGGTGATTGGCTACAGGCTGATGGGGAAGCCCCACCCTCTGGTAACATCCACTGACATCGTGC
TCACCATTACCAAGCACCTCCGCCAGGTTGGGGTAGTGGGCAAATTTGTCGAGTTCTTCGGGCCTGGAGTAGCCCAGTTGTCCATTGCTG
ACCGAGCTACGATTGCTAACATGTGTCCAGAGTACGGAGCAACTGCTGCCTTTTTCCCAGTTGATGAAGTTAGTATCACGTACCTGGTGC
AAACAGGTCGTGATGAAGAAAAATTAAAGTATATTAAAAAATATCTTCAGGCTGTAGGAATGTTTCGAGATTTCAATGACCCTTCTCAAG
ACCCAGACTTCACCCAGGTTGTGGAATTAGATTTGAAAACAGTAGTGCCTTGCTGTAGTGGACCCAAAAGGCCTCAGGACAAAGTTGCTG
TGTCCGACATGAAAAAGGACTTTGAGAGCTGCCTTGGAGCCAAGCAAGGATTTAAAGGATTCCAAGTTGCTCCTGAACATCATAATGACC
ATAAGACCTTTATCTATGATAACACTGAATTCACCCTTGCTCATGGTTCTGTGGTCATTGCTGCCATTACTAGCTGCACAAACACCAGTA
ATCCGTCTGTGATGTTAGGGGCAGGATTGTTAGCAAAGAAAGCTGTGGATGCTGGCCTGAACGTGATGCCTTACATCAAAACTAGCCTGT
CTCCTGGGAGTGGCGTGGTCACCTACTACCTACAAGAAAGCGGAGTCATGCCTTATCTGTCTCAGCTTGGGTTTGACGTGGTGGGCTATG
GCTGCATGACCTGCATTGGCAACAGTGGGCCTTTACCTGAACCTGTGGTAGAAGCCATCACACAGGGAGACCTTGTAGCTGTTGGAGTAC
TATCTGGAAACAGGAATTTTGAAGGTCGAGTTCACCCCAACACCCGGGCCAACTATTTAGCCTCTCCCCCCTTAGTAATAGCATATGCAA
TTGCTGGAACCATCAGAATCGACTTTGAGAAAGAGCCATTGGGAGTAAATGCAAAGGGACAGCAGGTATTTCTGAAAGATATCTGGCCGA
CTAGAGACGAGATCCAGGCAGTGGAGCGTCAGTATGTCATCCCGGGGATGTTTAAGGAAGTCTATCAGAAAATAGAGACTGTGAATGAAA
GCTGGAATGCCTTAGCAACCCCATCAGATAAGCTGTTTTTCTGGAATTCCAAATCTACGTATATCAAATCACCACCATTCTTTGAAAACC
TGACTTTGGATCTTCAGCCCCCTAAATCTATAGTGGATGCCTATGTGCTGCTAAATTTGGGAGATTCGGTAACAACTGACCACATCTCCC
CAGCTGGAAATATTGCAAGAAACAGTCCTGCTGCTCGCTACTTAACTAACAGAGGCCTAACTCCACGAGAATTCAACTCCTATGGCTCCC
GCCGAGGTAATGACGCCGTCATGGCACGGGGAACATTTGCCAACATTCGCTTGTTAAACAGATTTTTGAACAAGCAGGCACCACAGACTA
TCCATCTGCCTTCTGGGGAAATCGAACTAGCGGAATTACTGGAGGAAGAAAAACTAAGTTGTGTGCCAGTGCTCATCTTTGCTAATAAGC
AGGATTTGCTCACAGCAGCCCCTGCCTCTGAAATTGCAGAAGGACTGAACCTGCATACCATCCGCGACCGAGTCTGGCAGATCCAGTCTT
GCTCAGCTCTCACAGGAGAGGGCGTTCAGGATGGCATGAACTGGGTCTGCAAAAATGTCAATGCAAAGAAGAAATAAAATCTAGACGAAT
GGAGATGCAGGAGCTGCGGGAGCCGAATTCGGTCCTGAAAAACACTAATTTGCTGCTTTCTGACCAAATGTTTTTCCATCTGTGTACAGC
TCCAGCTGTTTGAAGAGAGGGAACAACACGGTTTAGAAAGAATCCCCATTCCAGCAGTAGATTTAACTGATCTCTGAGGTTCAGTATCAT
TTTTCAAATAAAGGAATTATATTATTTCCTCTGCATAATTGAAATAGTATTAAATGTCTCAAAGCACATGATTAGAAAATGAGATCTTTT
AAATGAGCAAGAGATTGCATTGCAGTTTAGACAATTCCAGTGGGCTTTTTTTTCCTCTCAAAAAAAAAAAAAGAAAAAGAAAAAGAGGAA
GAAGCAGCTTTGCTGAGTTCATTTATTTACTGACCCGTCCCTTGCATTCCCTCCATGGTTTTGAAACCACAGACAGTGTTTGCTGGTGCT
GTCAGTGATTTTTACCGTCACTAGCCCAGCCAGGCTTCAGTCTGTCCGACAGGAAGCTGCTGGGTGGGGGTGGGGGGAGAAAAGGCAGAT
AATTAAACCATCTCATCGTCTTGCAGGTCGGAGACTACGTATGTAATCCTCACTCTTTGGACAGAAAAAAAAAAAAAAGTCTTTCTTGCA
GACAAGTCACTACAGAAACATACCCCATCCCACCCACCCCTGCCTCTGCCCCAGCCAGCCACACAGAGAAGCAAATTCTTATGACTTTTG
ACTGTAATGACATCTGGAATGTAAGGAGAGGTGGGAGGTTTAATTCCAGAAAAATTACAAGGTCCTTAAAAAGCTCTCACATCGAGGGCT
CAGGCTAGCGTAAACAGGCTTTCTCCAGCTCAGTGGAGCAGTGAGCAGCCGACTCTGAGATTAGCTGGCTTCTCCACGGCCGTCCTATAG
ACAGGATTTCTAAAGCTCAAAGAATTCTGTGTTTAAACGATCACAATAGGCCGCTGCTATCAGATTTTAGAAATAAATGCAGCTTTACCA
TGAACCTGCTCCACTGAGAAAAGCCAGGCAGATCGATTTTTAGATCAATTTTTACAGTGCTGGCAACTTGGTGGTGTGGGATGCTCCTGG
ATGGAGAGGGTTTGCTGCTGGGGAGGACATGGGTGTGTGTGTGACTGCAGGGGTCGTGTCCAAGGAATCAAGAGTCACCCCAGCTGCTGG
GCTCCTCTGCCTCTCTGCAGCAGAATGTCCGTCCTCTGTTGATTGATTGGAGAGGAATAGCAGAACATTTCTCCTGCCCCTCGTTGCAAA
ACGAGCTTGTTTCCCTGAACCTCAGAAATCCTCAGCTTCAAACATGGGGAAACAGGCCAGAGCATTGCCCGGCTCCTGAATTAAACTCTG
TTCTGGTGCCTGAGCTCAGGGGTTTTCAGAGAATGAATAAGAGACTGTCCAGTGACTGGTGGGTCCCTGGGGGCCAGCTGCCTTCTCATC
CTGGGAGGTGGCCCTTCCCAAGCCCATCAGGGCGTGTGAGCAGACTGAAGGGGCCGCTGCAGCCCCTGGCCCTCAATACCCAGCTGCTTC
TGGCTAAGAGTGCAGCAGAGACTGAGGCATAGCCAGCTTCAAAAGCGATCTGACATGAAAGTCATTAACAAAGCCAGCCGTGAAAAGGTG
CCCCAGAGTTGCTGTGGACAGACCTGTAAGGACTTGCAAAACAAAAGAAAGTGAGGGGTTTTTTTAACCTCAGAGCTAGCTGCTCTCTGC
AGCCTCCTCCACTGGCTTCTCTGGCTCACCCAAGCTCTCCCTTACAGAGGCAACACAGAATTATAAGGAATCAGAAATCCCCCTTCTACC
AGGCTGCAAATGTGGCTCTAGCACTTGCAAATTGTTTTTTCTTCCGAATAGTTCAGCAGGGACAAGTTATCTGAGGGGCAAAATGCCTGC
TTGGAGGTCTGCAATTTTGGAACACTGCAGTATGGAACTTTGGCATTGGAGGGTCTGTAAAATATTTTTGTTCTTTTACCACCAACTTAG
GGGACTGTTTTAAAGAGCCATCCCAAGGCCTCTCCTAGCAGGCAGAAGCCACTCCTCTGATAACGGCCTCTGTAAATGTTCTGATTTGCT
CTCAGCTGCAGAGACACAGAGACACTGCAGATGTCACACGCTTTCATCTTCCCTTTGAGCCCTTTTGAACCCTCCTGGGGCTCTGGGGTA
GATGAGAGAAGCCTGAAAAAGGCAGAGTTTGAAAGCTCCCATTTAAAAACAAAATACTTTTTAAAGCCCTCTTGCCTCTTCCCTGCCCAC
TCCTGCCCCCTGACCAGAAGACAGAATTTGAAGCTGGAAAGGGAAGACCCCTTTTCCCCTCCTCCTGTCCCCAGTGAGTCTTAGCGAGAC
TTTTGCCCTGCGCACAATTGCATCTGAATGTGCGGGGGAGAGGGCTGGGGGCCGGAGGGCAGGCAAGGCCTGGGGGGTGCTCGTGATATG
TGCTCAAGCCAGTTGTGGGAAAAACTCGAGTCCTCCCCTCCTCCCGACCTACCCCGTGTGGCTGCTTTTGGCTGGATTCCCTGCACCCAG
TGCAACACACCCTTTCCCCTTCACTCTCCCTTGGTTACTATGGAAACAAGGGTGTCATTGATGTGGGCTGAGCTGGGGAACATGTCGGTG
CACAGCTGAAAGTCAGCGATTATGCCGGCGGTTAGAAATGTGCCAGGGTTAAAGGAGTCCGCAGCTCCCACGGCTGCTGGGAGGACATGG
TCCTGCCCCCTTCCTTCCTCCCTCCCTCCGTCTCCACTTCTCTCTCCTTGCTTTTGACAAATTTCTTTATTCCCCTCTGGACTAAAGTAG
TGGCTATTTTTGTGCCACTCTGCGCCCCACCCTCACTGTTGGCCGCTCCTTATCCGGCCTGGCCTGGAGGGTGACACCATGTCACCCTCA
CCAGGACTCGTCTCTCCATTCCCGTCAGAGTTTGCTTTGATTTCCCTTTCCTTTCCTTCTCGGGGACCAGTTCTTACTTCCTTTTATTTT
TAGCTCTGCACTCCATGTGGTTTCAGGGTTCAGTCTGATCCATCAAAAGGTTCTTTTTTTATAATCCCTTTTGAAAATGATAATCAAAGG
AAGAGATGTGGTGTTTGGTCATGTGGAAAACTCAATGTATAATTTAGACGTCTGTCAAAAATCCGACAAATAAAATTTAGCTGGAACGAA

>1336_1336_2_ACO1-ARL3_ACO1_chr9_32436395_ENST00000379923_ARL3_chr10_104445758_ENST00000260746_length(amino acids)=845AA_BP=768
MSKSSFHHPGVWNTWPSVIMSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENILHWNVTQH
KNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGS
QAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKP
HPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVG
MFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVI
AAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAI
TQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKE
VYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGL
TPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEIELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHT

--------------------------------------------------------------
>1336_1336_3_ACO1-ARL3_ACO1_chr9_32436395_ENST00000541043_ARL3_chr10_104445758_ENST00000260746_length(transcript)=5850nt_BP=2453nt
GGGGCGAGAGGGGGCGGAGCGTGGAGGCGGCAGCTGGAACCGCGCAGCGCACGGGAACGCGTCCCGCTGCTTGGGTCAGGTTCGCCGGTC
GCGGGAGCCCCGCCGTGCAGTCGGAGAGGGTGTCACTCTGAGTGGTGCTTCCTCAGCCCCTGTCAAAAAGCAGTTTCCACCATCCTGGAG
TGTGGAACACGTGGCCATCAGTAATCATGAGCAACCCATTCGCACACCTTGCTGAGCCATTGGATCCTGTACAACCAGGAAAGAAATTCT
TCAATTTGAATAAATTGGAGGATTCAAGATATGGGCGCTTACCATTTTCGATCAGAGTTCTTCTGGAAGCAGCCATTCGGAATTGTGATG
AGTTTTTGGTGAAGAAACAGGATATTGAAAATATTCTACATTGGAATGTCACGCAGCACAAGAACATAGAAGTGCCATTTAAGCCTGCTC
GTGTCATCCTGCAGGACTTTACGGGTGTGCCCGCTGTGGTTGACTTTGCTGCAATGCGTGATGCTGTGAAAAAGTTAGGAGGAGATCCAG
AGAAAATAAACCCTGTCTGCCCTGCTGATCTTGTAATAGATCATTCCATCCAGGTTGATTTCAACAGAAGGGCAGACAGTTTACAGAAGA
ATCAAGACCTGGAATTTGAAAGAAATAGAGAGCGATTTGAATTTTTAAAGTGGGGTTCCCAGGCTTTTCACAACATGCGGATTATTCCCC
CTGGCTCAGGAATCATCCACCAGGTGAATTTGGAATATTTGGCAAGAGTGGTATTTGATCAGGATGGATATTATTACCCAGACAGCCTCG
TGGGCACAGACTCGCACACTACCATGATTGATGGCTTGGGCATTCTTGGTTGGGGTGTCGGTGGTATTGAAGCAGAAGCTGTCATGCTGG
GTCAGCCAATCAGTATGGTGCTTCCTCAGGTGATTGGCTACAGGCTGATGGGGAAGCCCCACCCTCTGGTAACATCCACTGACATCGTGC
TCACCATTACCAAGCACCTCCGCCAGGTTGGGGTAGTGGGCAAATTTGTCGAGTTCTTCGGGCCTGGAGTAGCCCAGTTGTCCATTGCTG
ACCGAGCTACGATTGCTAACATGTGTCCAGAGTACGGAGCAACTGCTGCCTTTTTCCCAGTTGATGAAGTTAGTATCACGTACCTGGTGC
AAACAGGTCGTGATGAAGAAAAATTAAAGTATATTAAAAAATATCTTCAGGCTGTAGGAATGTTTCGAGATTTCAATGACCCTTCTCAAG
ACCCAGACTTCACCCAGGTTGTGGAATTAGATTTGAAAACAGTAGTGCCTTGCTGTAGTGGACCCAAAAGGCCTCAGGACAAAGTTGCTG
TGTCCGACATGAAAAAGGACTTTGAGAGCTGCCTTGGAGCCAAGCAAGGATTTAAAGGATTCCAAGTTGCTCCTGAACATCATAATGACC
ATAAGACCTTTATCTATGATAACACTGAATTCACCCTTGCTCATGGTTCTGTGGTCATTGCTGCCATTACTAGCTGCACAAACACCAGTA
ATCCGTCTGTGATGTTAGGGGCAGGATTGTTAGCAAAGAAAGCTGTGGATGCTGGCCTGAACGTGATGCCTTACATCAAAACTAGCCTGT
CTCCTGGGAGTGGCGTGGTCACCTACTACCTACAAGAAAGCGGAGTCATGCCTTATCTGTCTCAGCTTGGGTTTGACGTGGTGGGCTATG
GCTGCATGACCTGCATTGGCAACAGTGGGCCTTTACCTGAACCTGTGGTAGAAGCCATCACACAGGGAGACCTTGTAGCTGTTGGAGTAC
TATCTGGAAACAGGAATTTTGAAGGTCGAGTTCACCCCAACACCCGGGCCAACTATTTAGCCTCTCCCCCCTTAGTAATAGCATATGCAA
TTGCTGGAACCATCAGAATCGACTTTGAGAAAGAGCCATTGGGAGTAAATGCAAAGGGACAGCAGGTATTTCTGAAAGATATCTGGCCGA
CTAGAGACGAGATCCAGGCAGTGGAGCGTCAGTATGTCATCCCGGGGATGTTTAAGGAAGTCTATCAGAAAATAGAGACTGTGAATGAAA
GCTGGAATGCCTTAGCAACCCCATCAGATAAGCTGTTTTTCTGGAATTCCAAATCTACGTATATCAAATCACCACCATTCTTTGAAAACC
TGACTTTGGATCTTCAGCCCCCTAAATCTATAGTGGATGCCTATGTGCTGCTAAATTTGGGAGATTCGGTAACAACTGACCACATCTCCC
CAGCTGGAAATATTGCAAGAAACAGTCCTGCTGCTCGCTACTTAACTAACAGAGGCCTAACTCCACGAGAATTCAACTCCTATGGCTCCC
GCCGAGGTAATGACGCCGTCATGGCACGGGGAACATTTGCCAACATTCGCTTGTTAAACAGATTTTTGAACAAGCAGGCACCACAGACTA
TCCATCTGCCTTCTGGGGAAATCGAACTAGCGGAATTACTGGAGGAAGAAAAACTAAGTTGTGTGCCAGTGCTCATCTTTGCTAATAAGC
AGGATTTGCTCACAGCAGCCCCTGCCTCTGAAATTGCAGAAGGACTGAACCTGCATACCATCCGCGACCGAGTCTGGCAGATCCAGTCTT
GCTCAGCTCTCACAGGAGAGGGCGTTCAGGATGGCATGAACTGGGTCTGCAAAAATGTCAATGCAAAGAAGAAATAAAATCTAGACGAAT
GGAGATGCAGGAGCTGCGGGAGCCGAATTCGGTCCTGAAAAACACTAATTTGCTGCTTTCTGACCAAATGTTTTTCCATCTGTGTACAGC
TCCAGCTGTTTGAAGAGAGGGAACAACACGGTTTAGAAAGAATCCCCATTCCAGCAGTAGATTTAACTGATCTCTGAGGTTCAGTATCAT
TTTTCAAATAAAGGAATTATATTATTTCCTCTGCATAATTGAAATAGTATTAAATGTCTCAAAGCACATGATTAGAAAATGAGATCTTTT
AAATGAGCAAGAGATTGCATTGCAGTTTAGACAATTCCAGTGGGCTTTTTTTTCCTCTCAAAAAAAAAAAAAGAAAAAGAAAAAGAGGAA
GAAGCAGCTTTGCTGAGTTCATTTATTTACTGACCCGTCCCTTGCATTCCCTCCATGGTTTTGAAACCACAGACAGTGTTTGCTGGTGCT
GTCAGTGATTTTTACCGTCACTAGCCCAGCCAGGCTTCAGTCTGTCCGACAGGAAGCTGCTGGGTGGGGGTGGGGGGAGAAAAGGCAGAT
AATTAAACCATCTCATCGTCTTGCAGGTCGGAGACTACGTATGTAATCCTCACTCTTTGGACAGAAAAAAAAAAAAAAGTCTTTCTTGCA
GACAAGTCACTACAGAAACATACCCCATCCCACCCACCCCTGCCTCTGCCCCAGCCAGCCACACAGAGAAGCAAATTCTTATGACTTTTG
ACTGTAATGACATCTGGAATGTAAGGAGAGGTGGGAGGTTTAATTCCAGAAAAATTACAAGGTCCTTAAAAAGCTCTCACATCGAGGGCT
CAGGCTAGCGTAAACAGGCTTTCTCCAGCTCAGTGGAGCAGTGAGCAGCCGACTCTGAGATTAGCTGGCTTCTCCACGGCCGTCCTATAG
ACAGGATTTCTAAAGCTCAAAGAATTCTGTGTTTAAACGATCACAATAGGCCGCTGCTATCAGATTTTAGAAATAAATGCAGCTTTACCA
TGAACCTGCTCCACTGAGAAAAGCCAGGCAGATCGATTTTTAGATCAATTTTTACAGTGCTGGCAACTTGGTGGTGTGGGATGCTCCTGG
ATGGAGAGGGTTTGCTGCTGGGGAGGACATGGGTGTGTGTGTGACTGCAGGGGTCGTGTCCAAGGAATCAAGAGTCACCCCAGCTGCTGG
GCTCCTCTGCCTCTCTGCAGCAGAATGTCCGTCCTCTGTTGATTGATTGGAGAGGAATAGCAGAACATTTCTCCTGCCCCTCGTTGCAAA
ACGAGCTTGTTTCCCTGAACCTCAGAAATCCTCAGCTTCAAACATGGGGAAACAGGCCAGAGCATTGCCCGGCTCCTGAATTAAACTCTG
TTCTGGTGCCTGAGCTCAGGGGTTTTCAGAGAATGAATAAGAGACTGTCCAGTGACTGGTGGGTCCCTGGGGGCCAGCTGCCTTCTCATC
CTGGGAGGTGGCCCTTCCCAAGCCCATCAGGGCGTGTGAGCAGACTGAAGGGGCCGCTGCAGCCCCTGGCCCTCAATACCCAGCTGCTTC
TGGCTAAGAGTGCAGCAGAGACTGAGGCATAGCCAGCTTCAAAAGCGATCTGACATGAAAGTCATTAACAAAGCCAGCCGTGAAAAGGTG
CCCCAGAGTTGCTGTGGACAGACCTGTAAGGACTTGCAAAACAAAAGAAAGTGAGGGGTTTTTTTAACCTCAGAGCTAGCTGCTCTCTGC
AGCCTCCTCCACTGGCTTCTCTGGCTCACCCAAGCTCTCCCTTACAGAGGCAACACAGAATTATAAGGAATCAGAAATCCCCCTTCTACC
AGGCTGCAAATGTGGCTCTAGCACTTGCAAATTGTTTTTTCTTCCGAATAGTTCAGCAGGGACAAGTTATCTGAGGGGCAAAATGCCTGC
TTGGAGGTCTGCAATTTTGGAACACTGCAGTATGGAACTTTGGCATTGGAGGGTCTGTAAAATATTTTTGTTCTTTTACCACCAACTTAG
GGGACTGTTTTAAAGAGCCATCCCAAGGCCTCTCCTAGCAGGCAGAAGCCACTCCTCTGATAACGGCCTCTGTAAATGTTCTGATTTGCT
CTCAGCTGCAGAGACACAGAGACACTGCAGATGTCACACGCTTTCATCTTCCCTTTGAGCCCTTTTGAACCCTCCTGGGGCTCTGGGGTA
GATGAGAGAAGCCTGAAAAAGGCAGAGTTTGAAAGCTCCCATTTAAAAACAAAATACTTTTTAAAGCCCTCTTGCCTCTTCCCTGCCCAC
TCCTGCCCCCTGACCAGAAGACAGAATTTGAAGCTGGAAAGGGAAGACCCCTTTTCCCCTCCTCCTGTCCCCAGTGAGTCTTAGCGAGAC
TTTTGCCCTGCGCACAATTGCATCTGAATGTGCGGGGGAGAGGGCTGGGGGCCGGAGGGCAGGCAAGGCCTGGGGGGTGCTCGTGATATG
TGCTCAAGCCAGTTGTGGGAAAAACTCGAGTCCTCCCCTCCTCCCGACCTACCCCGTGTGGCTGCTTTTGGCTGGATTCCCTGCACCCAG
TGCAACACACCCTTTCCCCTTCACTCTCCCTTGGTTACTATGGAAACAAGGGTGTCATTGATGTGGGCTGAGCTGGGGAACATGTCGGTG
CACAGCTGAAAGTCAGCGATTATGCCGGCGGTTAGAAATGTGCCAGGGTTAAAGGAGTCCGCAGCTCCCACGGCTGCTGGGAGGACATGG
TCCTGCCCCCTTCCTTCCTCCCTCCCTCCGTCTCCACTTCTCTCTCCTTGCTTTTGACAAATTTCTTTATTCCCCTCTGGACTAAAGTAG
TGGCTATTTTTGTGCCACTCTGCGCCCCACCCTCACTGTTGGCCGCTCCTTATCCGGCCTGGCCTGGAGGGTGACACCATGTCACCCTCA
CCAGGACTCGTCTCTCCATTCCCGTCAGAGTTTGCTTTGATTTCCCTTTCCTTTCCTTCTCGGGGACCAGTTCTTACTTCCTTTTATTTT
TAGCTCTGCACTCCATGTGGTTTCAGGGTTCAGTCTGATCCATCAAAAGGTTCTTTTTTTATAATCCCTTTTGAAAATGATAATCAAAGG
AAGAGATGTGGTGTTTGGTCATGTGGAAAACTCAATGTATAATTTAGACGTCTGTCAAAAATCCGACAAATAAAATTTAGCTGGAACGAA

>1336_1336_3_ACO1-ARL3_ACO1_chr9_32436395_ENST00000541043_ARL3_chr10_104445758_ENST00000260746_length(amino acids)=845AA_BP=768
MSKSSFHHPGVWNTWPSVIMSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENILHWNVTQH
KNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGS
QAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKP
HPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVG
MFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVI
AAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAI
TQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKE
VYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGL
TPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEIELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACO1-ARL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACO1-ARL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACO1-ARL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACO1C0027626Neoplasm Invasiveness1CTD_human
HgeneACO1C0029408Degenerative polyarthritis1CTD_human
HgeneACO1C0086743Osteoarthrosis Deformans1CTD_human
TgeneC0035334Retinitis Pigmentosa1ORPHANET
TgeneC0431399Familial aplasia of the vermis1ORPHANET
TgeneC3553264JOUBERT SYNDROME 171GENOMICS_ENGLAND
TgeneC4551568Joubert syndrome 11ORPHANET
TgeneC4748442JOUBERT SYNDROME 351UNIPROT
TgeneC4748536RETINITIS PIGMENTOSA 831UNIPROT