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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:OPRM1-JAZF1-AS1 (FusionGDB2 ID:HG4988TG100128081)

Fusion Gene Summary for OPRM1-JAZF1-AS1

check button Fusion gene summary
Fusion gene informationFusion gene name: OPRM1-JAZF1-AS1
Fusion gene ID: hg4988tg100128081
HgeneTgene
Gene symbol

OPRM1

JAZF1-AS1

Gene ID

4988

100128081

Gene nameopioid receptor mu 1JAZF1 antisense RNA 1
SynonymsLMOR|M-OR-1|MOP|MOR|MOR1|OPRM-
Cytomap('OPRM1')('JAZF1-AS1')

6q25.2

7p15.1

Type of geneprotein-codingncRNA
Descriptionmu-type opioid receptormu opiate receptormu opioid receptor hMOR-1aJAZF1 antisense RNA 1 (non-protein coding)
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000229768, ENST00000330432, 
ENST00000337049, ENST00000360422, 
ENST00000414028, ENST00000419506, 
ENST00000428397, ENST00000434900, 
ENST00000435918, ENST00000452687, 
ENST00000518759, ENST00000520708, 
ENST00000522236, ENST00000522555, 
ENST00000523520, ENST00000524163, 
Fusion gene scores* DoF score11 X 4 X 2=881 X 1 X 1=1
# samples 101
** MAII scorelog2(10/88*10)=0.184424571137427
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: OPRM1 [Title/Abstract] AND JAZF1-AS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOPRM1(154424052)-JAZF1-AS1(28281630), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for OPRM1-JAZF1-AS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for OPRM1-JAZF1-AS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for OPRM1-JAZF1-AS1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:154424052/:28281630)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for OPRM1-JAZF1-AS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for OPRM1-JAZF1-AS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for OPRM1-JAZF1-AS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for OPRM1-JAZF1-AS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOPRM1C0001973Alcoholic Intoxication, Chronic6CTD_human;PSYGENET
HgeneOPRM1C0600427Cocaine Dependence6CTD_human;PSYGENET
HgeneOPRM1C0001969Alcoholic Intoxication5PSYGENET
HgeneOPRM1C0011570Mental Depression4PSYGENET
HgeneOPRM1C0011581Depressive disorder4PSYGENET
HgeneOPRM1C0009171Cocaine Abuse3CTD_human
HgeneOPRM1C0036341Schizophrenia3PSYGENET
HgeneOPRM1C0085762Alcohol abuse3CTD_human;PSYGENET
HgeneOPRM1C0236736Cocaine-Related Disorders3CTD_human
HgeneOPRM1C0019196Hepatitis C2CTD_human
HgeneOPRM1C0022333Jacksonian Seizure2CTD_human
HgeneOPRM1C0027796Neuralgia2CTD_human
HgeneOPRM1C0033975Psychotic Disorders2PSYGENET
HgeneOPRM1C0036572Seizures2CTD_human
HgeneOPRM1C0038870Neuralgia, Supraorbital2CTD_human
HgeneOPRM1C0042656Neuralgia, Vidian2CTD_human
HgeneOPRM1C0149958Complex partial seizures2CTD_human
HgeneOPRM1C0234247Neuralgia, Atypical2CTD_human
HgeneOPRM1C0234249Neuralgia, Stump2CTD_human
HgeneOPRM1C0234533Generalized seizures2CTD_human
HgeneOPRM1C0234535Clonic Seizures2CTD_human
HgeneOPRM1C0270824Visual seizure2CTD_human
HgeneOPRM1C0270844Tonic Seizures2CTD_human
HgeneOPRM1C0270846Epileptic drop attack2CTD_human
HgeneOPRM1C0349204Nonorganic psychosis2PSYGENET
HgeneOPRM1C0422850Seizures, Somatosensory2CTD_human
HgeneOPRM1C0422852Seizures, Auditory2CTD_human
HgeneOPRM1C0422853Olfactory seizure2CTD_human
HgeneOPRM1C0422854Gustatory seizure2CTD_human
HgeneOPRM1C0422855Vertiginous seizure2CTD_human
HgeneOPRM1C0423711Neuralgia, Perineal2CTD_human
HgeneOPRM1C0423712Neuralgia, Iliohypogastric Nerve2CTD_human
HgeneOPRM1C0494475Tonic - clonic seizures2CTD_human
HgeneOPRM1C0751056Non-epileptic convulsion2CTD_human
HgeneOPRM1C0751110Single Seizure2CTD_human
HgeneOPRM1C0751123Atonic Absence Seizures2CTD_human
HgeneOPRM1C0751371Neuralgia, Ilioinguinal2CTD_human
HgeneOPRM1C0751372Nerve Pain2CTD_human
HgeneOPRM1C0751373Paroxysmal Nerve Pain2CTD_human
HgeneOPRM1C0751494Convulsive Seizures2CTD_human
HgeneOPRM1C0751495Seizures, Focal2CTD_human
HgeneOPRM1C0751496Seizures, Sensory2CTD_human
HgeneOPRM1C3495874Nonepileptic Seizures2CTD_human
HgeneOPRM1C4048158Convulsions2CTD_human
HgeneOPRM1C4316903Absence Seizures2CTD_human
HgeneOPRM1C4317109Epileptic Seizures2CTD_human
HgeneOPRM1C4317123Myoclonic Seizures2CTD_human
HgeneOPRM1C4505436Generalized Absence Seizures2CTD_human
HgeneOPRM1C0001849AIDS Dementia Complex1CTD_human
HgeneOPRM1C0001956Alcohol Use Disorder1CTD_human
HgeneOPRM1C0009806Constipation1CTD_human
HgeneOPRM1C0013146Drug abuse1CTD_human
HgeneOPRM1C0013170Drug habituation1CTD_human
HgeneOPRM1C0013222Drug Use Disorders1CTD_human
HgeneOPRM1C0013384Dyskinetic syndrome1CTD_human
HgeneOPRM1C0014544Epilepsy1CTD_human
HgeneOPRM1C0019147Hepatic Coma1CTD_human
HgeneOPRM1C0019151Hepatic Encephalopathy1CTD_human
HgeneOPRM1C0019337Heroin Dependence1CTD_human
HgeneOPRM1C0020429Hyperalgesia1CTD_human
HgeneOPRM1C0020651Hypotension, Orthostatic1CTD_human
HgeneOPRM1C0026552Morphine Dependence1CTD_human
HgeneOPRM1C0026650Movement Disorders1CTD_human
HgeneOPRM1C0027497Nausea1CTD_human
HgeneOPRM1C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneOPRM1C0033774Pruritus1CTD_human
HgeneOPRM1C0033937Psychoses, Drug1CTD_human
HgeneOPRM1C0033941Psychoses, Substance-Induced1CTD_human
HgeneOPRM1C0035229Respiratory Insufficiency1CTD_human
HgeneOPRM1C0038580Substance Dependence1CTD_human
HgeneOPRM1C0038586Substance Use Disorders1CTD_human
HgeneOPRM1C0086237Epilepsy, Cryptogenic1CTD_human
HgeneOPRM1C0152115Lingual-Facial-Buccal Dyskinesia1CTD_human
HgeneOPRM1C0206019HIV Encephalopathy1CTD_human
HgeneOPRM1C0221074Depression, Postpartum1PSYGENET
HgeneOPRM1C0221169Hemiballismus1CTD_human
HgeneOPRM1C0232766Asterixis1CTD_human
HgeneOPRM1C0233477Dysphoric mood1PSYGENET
HgeneOPRM1C0235063Respiratory Depression1CTD_human
HgeneOPRM1C0236018Aura1CTD_human
HgeneOPRM1C0236733Amphetamine-Related Disorders1CTD_human
HgeneOPRM1C0236804Amphetamine Addiction1CTD_human
HgeneOPRM1C0236807Amphetamine Abuse1CTD_human
HgeneOPRM1C0236969Substance-Related Disorders1CTD_human
HgeneOPRM1C0237326Dyschezia1CTD_human
HgeneOPRM1C0243010Viral Encephalitis1CTD_human
HgeneOPRM1C0266487Etat Marbre1CTD_human
HgeneOPRM1C0427086Involuntary Movements1CTD_human
HgeneOPRM1C0454606Oral Dyskinesia1CTD_human
HgeneOPRM1C0458247Allodynia1CTD_human
HgeneOPRM1C0600241heroin abuse1CTD_human
HgeneOPRM1C0600272Morphine Abuse1CTD_human
HgeneOPRM1C0740858Substance abuse problem1CTD_human
HgeneOPRM1C0751111Awakening Epilepsy1CTD_human
HgeneOPRM1C0751197Fulminant Hepatic Failure with Cerebral Edema1CTD_human
HgeneOPRM1C0751198Hepatic Stupor1CTD_human
HgeneOPRM1C0751211Hyperalgesia, Primary1CTD_human
HgeneOPRM1C0751212Hyperalgesia, Secondary1CTD_human
HgeneOPRM1C0751213Tactile Allodynia1CTD_human
HgeneOPRM1C0751214Hyperalgesia, Thermal1CTD_human
HgeneOPRM1C0752196Ballismus1CTD_human
HgeneOPRM1C0936243HIV-1-Associated Cognitive Motor Complex1CTD_human
HgeneOPRM1C1145670Respiratory Failure1CTD_human
HgeneOPRM1C1257861Colonic Inertia1CTD_human
HgeneOPRM1C1510472Drug Dependence1CTD_human
HgeneOPRM1C1837893SCHIZOPHRENIA 121PSYGENET
HgeneOPRM1C2936719Mechanical Allodynia1CTD_human
HgeneOPRM1C4316881Prescription Drug Abuse1CTD_human
HgeneOPRM1C4505390Heroin Smoking1CTD_human