Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:APH1A-RGS4 (FusionGDB2 ID:HG51107TG5999)

Fusion Gene Summary for APH1A-RGS4

check button Fusion gene summary
Fusion gene informationFusion gene name: APH1A-RGS4
Fusion gene ID: hg51107tg5999
HgeneTgene
Gene symbol

APH1A

RGS4

Gene ID

51107

5999

Gene nameaph-1 homolog A, gamma-secretase subunitregulator of G protein signaling 4
Synonyms6530402N02Rik|APH-1|APH-1A|CGI-78RGP4|SCZD9
Cytomap('APH1A')('RGS4')

1q21.2

1q23.3

Type of geneprotein-codingprotein-coding
Descriptiongamma-secretase subunit APH-1AAPH1A gamma secretase subunitanterior pharynx defective 1 homolog Aaph-1alphapresenilin-stabilization factorregulator of G-protein signaling 4schizophrenia disorder 9
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000360244, ENST00000369109, 
ENST00000414276, ENST00000461320, 
Fusion gene scores* DoF score3 X 5 X 3=451 X 1 X 1=1
# samples 41
** MAII scorelog2(4/45*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: APH1A [Title/Abstract] AND RGS4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPH1A(150241098)-RGS4(163039042), # samples:2
Anticipated loss of major functional domain due to fusion event.APH1A-RGS4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APH1A-RGS4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APH1A-RGS4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPH1A

GO:0006509

membrane protein ectodomain proteolysis

15274632

HgeneAPH1A

GO:0016485

protein processing

15274632

HgeneAPH1A

GO:0042982

amyloid precursor protein metabolic process

25043039|26280335

HgeneAPH1A

GO:0043085

positive regulation of catalytic activity

15274632


check buttonFusion gene breakpoints across APH1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RGS4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0YG-01AAPH1Achr1

150239756

-RGS4chr1

163039042

+
ChimerDB4BRCATCGA-A2-A0YG-01AAPH1Achr1

150241098

-RGS4chr1

163039042

+


Top

Fusion Gene ORF analysis for APH1A-RGS4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000360244ENST00000367909APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-5UTRENST00000360244ENST00000367909APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-5UTRENST00000369109ENST00000367909APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-5UTRENST00000369109ENST00000367909APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-5UTRENST00000414276ENST00000367909APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-5UTRENST00000414276ENST00000367909APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-intronENST00000360244ENST00000367906APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-intronENST00000360244ENST00000367906APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-intronENST00000360244ENST00000367908APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-intronENST00000360244ENST00000367908APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-intronENST00000360244ENST00000491263APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-intronENST00000360244ENST00000491263APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-intronENST00000360244ENST00000527809APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-intronENST00000360244ENST00000527809APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-intronENST00000360244ENST00000531057APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-intronENST00000360244ENST00000531057APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-intronENST00000369109ENST00000367906APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-intronENST00000369109ENST00000367906APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-intronENST00000369109ENST00000367908APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-intronENST00000369109ENST00000367908APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-intronENST00000369109ENST00000491263APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-intronENST00000369109ENST00000491263APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-intronENST00000369109ENST00000527809APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-intronENST00000369109ENST00000527809APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-intronENST00000369109ENST00000531057APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-intronENST00000369109ENST00000531057APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-intronENST00000414276ENST00000367906APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-intronENST00000414276ENST00000367906APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-intronENST00000414276ENST00000367908APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-intronENST00000414276ENST00000367908APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-intronENST00000414276ENST00000491263APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-intronENST00000414276ENST00000491263APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-intronENST00000414276ENST00000527809APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-intronENST00000414276ENST00000527809APH1Achr1

150241098

-RGS4chr1

163039042

+
5CDS-intronENST00000414276ENST00000531057APH1Achr1

150239756

-RGS4chr1

163039042

+
5CDS-intronENST00000414276ENST00000531057APH1Achr1

150241098

-RGS4chr1

163039042

+
5UTR-3CDSENST00000461320ENST00000421743APH1Achr1

150239756

-RGS4chr1

163039042

+
5UTR-3CDSENST00000461320ENST00000421743APH1Achr1

150241098

-RGS4chr1

163039042

+
5UTR-5UTRENST00000461320ENST00000367909APH1Achr1

150239756

-RGS4chr1

163039042

+
5UTR-5UTRENST00000461320ENST00000367909APH1Achr1

150241098

-RGS4chr1

163039042

+
5UTR-intronENST00000461320ENST00000367906APH1Achr1

150239756

-RGS4chr1

163039042

+
5UTR-intronENST00000461320ENST00000367906APH1Achr1

150241098

-RGS4chr1

163039042

+
5UTR-intronENST00000461320ENST00000367908APH1Achr1

150239756

-RGS4chr1

163039042

+
5UTR-intronENST00000461320ENST00000367908APH1Achr1

150241098

-RGS4chr1

163039042

+
5UTR-intronENST00000461320ENST00000491263APH1Achr1

150239756

-RGS4chr1

163039042

+
5UTR-intronENST00000461320ENST00000491263APH1Achr1

150241098

-RGS4chr1

163039042

+
5UTR-intronENST00000461320ENST00000527809APH1Achr1

150239756

-RGS4chr1

163039042

+
5UTR-intronENST00000461320ENST00000527809APH1Achr1

150241098

-RGS4chr1

163039042

+
5UTR-intronENST00000461320ENST00000531057APH1Achr1

150239756

-RGS4chr1

163039042

+
5UTR-intronENST00000461320ENST00000531057APH1Achr1

150241098

-RGS4chr1

163039042

+
Frame-shiftENST00000360244ENST00000421743APH1Achr1

150241098

-RGS4chr1

163039042

+
Frame-shiftENST00000369109ENST00000421743APH1Achr1

150241098

-RGS4chr1

163039042

+
Frame-shiftENST00000414276ENST00000421743APH1Achr1

150241098

-RGS4chr1

163039042

+
In-frameENST00000360244ENST00000421743APH1Achr1

150239756

-RGS4chr1

163039042

+
In-frameENST00000369109ENST00000421743APH1Achr1

150239756

-RGS4chr1

163039042

+
In-frameENST00000414276ENST00000421743APH1Achr1

150239756

-RGS4chr1

163039042

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369109APH1Achr1150239756-ENST00000421743RGS4chr1163039042+37636701891520443
ENST00000360244APH1Achr1150239756-ENST00000421743RGS4chr1163039042+40679744931824443
ENST00000414276APH1Achr1150239756-ENST00000421743RGS4chr1163039042+35704772061327373

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369109ENST00000421743APH1Achr1150239756-RGS4chr1163039042+0.0004723850.9995276
ENST00000360244ENST00000421743APH1Achr1150239756-RGS4chr1163039042+0.0005658880.99943405
ENST00000414276ENST00000421743APH1Achr1150239756-RGS4chr1163039042+0.0003089390.9996911

Top

Fusion Genomic Features for APH1A-RGS4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
APH1Achr1150239755-RGS4chr1163039041+0.0025556160.9974444
APH1Achr1150241097-RGS4chr1163039041+0.0015103870.9984896
APH1Achr1150239755-RGS4chr1163039041+0.0025556160.9974444
APH1Achr1150241097-RGS4chr1163039041+0.0015103870.9984896

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for APH1A-RGS4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:150241098/chr1:163039042)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPH1Achr1:150239756chr1:163039042ENST00000360244-46140_158160248.0Topological domainLumenal
HgeneAPH1Achr1:150239756chr1:163039042ENST00000360244-461_2160248.0Topological domainLumenal
HgeneAPH1Achr1:150239756chr1:163039042ENST00000360244-4624_31160248.0Topological domainCytoplasmic
HgeneAPH1Achr1:150239756chr1:163039042ENST00000360244-4653_68160248.0Topological domainLumenal
HgeneAPH1Achr1:150239756chr1:163039042ENST00000360244-4690_118160248.0Topological domainCytoplasmic
HgeneAPH1Achr1:150239756chr1:163039042ENST00000369109-47140_158160266.0Topological domainLumenal
HgeneAPH1Achr1:150239756chr1:163039042ENST00000369109-471_2160266.0Topological domainLumenal
HgeneAPH1Achr1:150239756chr1:163039042ENST00000369109-4724_31160266.0Topological domainCytoplasmic
HgeneAPH1Achr1:150239756chr1:163039042ENST00000369109-4753_68160266.0Topological domainLumenal
HgeneAPH1Achr1:150239756chr1:163039042ENST00000369109-4790_118160266.0Topological domainCytoplasmic
HgeneAPH1Achr1:150239756chr1:163039042ENST00000414276-361_290196.0Topological domainLumenal
HgeneAPH1Achr1:150239756chr1:163039042ENST00000414276-3624_3190196.0Topological domainCytoplasmic
HgeneAPH1Achr1:150239756chr1:163039042ENST00000414276-3653_6890196.0Topological domainLumenal
HgeneAPH1Achr1:150239756chr1:163039042ENST00000360244-46119_139160248.0TransmembraneHelical%3B Name%3D4
HgeneAPH1Achr1:150239756chr1:163039042ENST00000360244-4632_52160248.0TransmembraneHelical%3B Name%3D2
HgeneAPH1Achr1:150239756chr1:163039042ENST00000360244-463_23160248.0TransmembraneHelical%3B Name%3D1
HgeneAPH1Achr1:150239756chr1:163039042ENST00000360244-4669_89160248.0TransmembraneHelical%3B Name%3D3
HgeneAPH1Achr1:150239756chr1:163039042ENST00000369109-47119_139160266.0TransmembraneHelical%3B Name%3D4
HgeneAPH1Achr1:150239756chr1:163039042ENST00000369109-4732_52160266.0TransmembraneHelical%3B Name%3D2
HgeneAPH1Achr1:150239756chr1:163039042ENST00000369109-473_23160266.0TransmembraneHelical%3B Name%3D1
HgeneAPH1Achr1:150239756chr1:163039042ENST00000369109-4769_89160266.0TransmembraneHelical%3B Name%3D3
HgeneAPH1Achr1:150239756chr1:163039042ENST00000414276-3632_5290196.0TransmembraneHelical%3B Name%3D2
HgeneAPH1Achr1:150239756chr1:163039042ENST00000414276-363_2390196.0TransmembraneHelical%3B Name%3D1
HgeneAPH1Achr1:150239756chr1:163039042ENST00000414276-3669_8990196.0TransmembraneHelical%3B Name%3D3
TgeneRGS4chr1:150239756chr1:163039042ENST000003679060562_1780188.0DomainRGS
TgeneRGS4chr1:150239756chr1:163039042ENST000003679080462_178094.0DomainRGS
TgeneRGS4chr1:150239756chr1:163039042ENST000003679090562_1780206.0DomainRGS
TgeneRGS4chr1:150239756chr1:163039042ENST000004217430662_17819303.0DomainRGS
TgeneRGS4chr1:150239756chr1:163039042ENST000005278090562_1780188.0DomainRGS

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPH1Achr1:150239756chr1:163039042ENST00000360244-46180_186160248.0Topological domainCytoplasmic
HgeneAPH1Achr1:150239756chr1:163039042ENST00000360244-46208_213160248.0Topological domainLumenal
HgeneAPH1Achr1:150239756chr1:163039042ENST00000360244-46235_265160248.0Topological domainCytoplasmic
HgeneAPH1Achr1:150239756chr1:163039042ENST00000369109-47180_186160266.0Topological domainCytoplasmic
HgeneAPH1Achr1:150239756chr1:163039042ENST00000369109-47208_213160266.0Topological domainLumenal
HgeneAPH1Achr1:150239756chr1:163039042ENST00000369109-47235_265160266.0Topological domainCytoplasmic
HgeneAPH1Achr1:150239756chr1:163039042ENST00000414276-36140_15890196.0Topological domainLumenal
HgeneAPH1Achr1:150239756chr1:163039042ENST00000414276-36180_18690196.0Topological domainCytoplasmic
HgeneAPH1Achr1:150239756chr1:163039042ENST00000414276-36208_21390196.0Topological domainLumenal
HgeneAPH1Achr1:150239756chr1:163039042ENST00000414276-36235_26590196.0Topological domainCytoplasmic
HgeneAPH1Achr1:150239756chr1:163039042ENST00000414276-3690_11890196.0Topological domainCytoplasmic
HgeneAPH1Achr1:150239756chr1:163039042ENST00000360244-46159_179160248.0TransmembraneHelical%3B Name%3D5
HgeneAPH1Achr1:150239756chr1:163039042ENST00000360244-46187_207160248.0TransmembraneHelical%3B Name%3D6
HgeneAPH1Achr1:150239756chr1:163039042ENST00000360244-46214_234160248.0TransmembraneHelical%3B Name%3D7
HgeneAPH1Achr1:150239756chr1:163039042ENST00000369109-47159_179160266.0TransmembraneHelical%3B Name%3D5
HgeneAPH1Achr1:150239756chr1:163039042ENST00000369109-47187_207160266.0TransmembraneHelical%3B Name%3D6
HgeneAPH1Achr1:150239756chr1:163039042ENST00000369109-47214_234160266.0TransmembraneHelical%3B Name%3D7
HgeneAPH1Achr1:150239756chr1:163039042ENST00000414276-36119_13990196.0TransmembraneHelical%3B Name%3D4
HgeneAPH1Achr1:150239756chr1:163039042ENST00000414276-36159_17990196.0TransmembraneHelical%3B Name%3D5
HgeneAPH1Achr1:150239756chr1:163039042ENST00000414276-36187_20790196.0TransmembraneHelical%3B Name%3D6
HgeneAPH1Achr1:150239756chr1:163039042ENST00000414276-36214_23490196.0TransmembraneHelical%3B Name%3D7


Top

Fusion Gene Sequence for APH1A-RGS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5408_5408_1_APH1A-RGS4_APH1A_chr1_150239756_ENST00000360244_RGS4_chr1_163039042_ENST00000421743_length(transcript)=4067nt_BP=974nt
AGCCCTTCAAGAAGAGGTATGATTGCTACCACTTTTCCCCACAAAGTGACGAAAGGAAACAGCGACGGAAGCGCAACCGAACCCTGGAAT
TGGTGTCTCGACTGGTCCATTCCCGGCCCACCCCCATTAACCGGCTCGAGCCACTCCCAGGACGAAGTCAAGGCCTCGGAAGGCGACTAC
AACTCCCAGCAGGTCGAGCAGCTCCGCCCGCGCTGATTCTCCATTGGCCTTCCGGGGGTGGGGATTAGATGGGAGGTGGCCGTGGGGCTG
CGGCCGGGATTTGTCCCCTCTTCGGCTTCCGTAGAGGAAGTGGCGCGGACCTTCATTTGGGGTTTCGGTTCCCCCCCTTCCCCTTCCCCG
GGGTCTGGGGGTGACATTGCACCGCGCCCCTCGTGGGGTCGCGTTGCCACCCCACGCGGACTCCCCAGCTGGCGCGCCCCTCCCATTTGC
CTGTCCTGGTCAGGCCCCCACCCCCCTTCCCACCTGACCAGCCATGGGGGCTGCGGTGTTTTTCGGCTGCACTTTCGTCGCGTTCGGCCC
GGCCTTCGCGCTTTTCTTGATCACTGTGGCTGGGGACCCGCTTCGCGTTATCATCCTGGTCGCAGGGGCATTTTTCTGGCTGGTCTCCCT
GCTCCTGGCCTCTGTGGTCTGGTTCATCTTGGTCCATGTGACCGACCGGTCAGATGCCCGGCTCCAGTACGGCCTCCTGATTTTTGGTGC
TGCTGTCTCTGTCCTTCTACAGGAGGTGTTCCGCTTTGCCTACTACAAGCTGCTTAAGAAGGCAGATGAGGGGTTAGCATCGCTGAGTGA
GGACGGAAGATCACCCATCTCCATCCGCCAGATGGCCTATGTTTCTGGTCTCTCCTTCGGTATCATCAGTGGTGTCTTCTCTGTTATCAA
TATTTTGGCTGATGCACTTGGGCCAGGTGTGGTTGGGATCCATGGAGACTCACCCTATTACTTCCTGACTTCAGGGGCTGGAGAGGCAGA
GGGAGACAGAGGAGCTGGTACTGCAGAGCGGTCGTCTGATTGGCTGGACGGTCGTAGCTGGGCTATAAAAGAGACCCCTACAGGCTTAGC
AGGAAGACGCTCAGAGGATTCTGACAATATCTTTACCGGAGAAGAGGCAAAGTACGCTCAAAGCCGAAGCCACAGCTCCTCCTGCCGCAT
TTCTTTCCTGCTTGCGAATTCCAAGCTGTTAAATAAGATGTGCAAAGGGCTTGCAGGTCTGCCGGCTTCTTGCTTGAGGAGTGCAAAAGA
TATGAAACATCGGCTAGGTTTCCTGCTGCAAAAATCTGATTCCTGTGAACACAATTCTTCCCACAACAAGAAGGACAAAGTGGTTATTTG
CCAGAGAGTGAGCCAAGAGGAAGTCAAGAAATGGGCTGAATCACTGGAAAACCTGATTAGTCATGAATGTGGGCTGGCAGCTTTCAAAGC
TTTCTTGAAGTCTGAATATAGTGAGGAGAATATTGACTTCTGGATCAGCTGTGAAGAGTACAAGAAAATCAAATCACCATCTAAACTAAG
TCCCAAGGCCAAAAAGATCTATAATGAATTCATCTCAGTCCAGGCAACCAAAGAGGTGAACCTGGATTCTTGCACCAGGGAAGAGACAAG
CCGGAACATGCTAGAGCCTACAATAACCTGCTTTGATGAGGCCCAGAAGAAGATTTTCAACCTGATGGAGAAGGATTCCTACCGCCGCTT
CCTCAAGTCTCGATTCTATCTTGATTTGGTCAACCCGTCCAGCTGTGGGGCAGAAAAGCAGAAAGGAGCCAAGAGTTCAGCAGACTGTGC
TTCCCTGGTCCCTCAGTGTGCCTAATTCTCACCTGAAGGCAGAGGGATGAAATGCCAAGACTCTATGCTCTGGAAAACCTGAGGCCAAAT
ATTGATCTGTATTAAGCTCCAGTGCTTTATCCACATTGTAGCCTAATATTCATGCTGCCTGCCATGTGTGAGTCACTTCTACGCATAAAC
TAGATATAGCTTTTGGTGTTTGAGTGTTCATCAGGGTGGGACCCCATTCCAGTCCAATTTTCCTAAGTTTCTTTGAGGGTTCCATGGGAG
CAAATATCTAAATAATGGCCTGGTAGGTCTGGATTTTCAAAGATTGTTGGCAGTTTCCTCCTCCCAACAGTTTTACCTCGGGATGGTTGG
TTAGTGCATGTCACATGACATCCACATGCACATGTATTCTGTTGGCCAGCACGTTCTCCAGACTCTAGATGTTTAGATGAGGTTGAGCTA
TGATATGTGCTTGTGTGTATGTCTATGTGTATATATTATATATACATTAGACACACATATACATTATTTCTGTATATAGATGTCTGTGTA
TACATATGTATGTGTGAGTGTATGTATACACACACACACACACACACACACACACTTTTGCAAGAGTGATGGGAAAGACCCTAGGTGCTC
ATAACTAGAGTATGTGTATGTACTTACATGGGTGTTTTGATCTCTGTTCTTTCATACTACATTTGAACAGGGCAAAATGAACTAACTGCC
ATGTAGGCTAAGAAAGAAATGCTAACCTGTGGAAAGTTGGTTTTGTAAAATTCCATGGATCTTGCTGGAGAAGCATCCAAGGAACTTCAT
GCTTGATTTGACCACTGACAGCCTCCACCTTGAGCACTATTCTAAGGAGCAAATACCTTAGCTCCCTTGAGCTGGTTTTCTCTGATGGCA
CTTTTGAGCTCCTAAGCTGCCAGCCTTCCCTTCTTTTCCTGGGTGCTCAGGGCATGCTTATTAGCAGCTGGGTTGGTATGGAGTTGGCAG
ACAGGATGTTCAACTTAATGAAGAAATACAGCTAAGGCCTTGCCAGCAACACCTGCCGTAAGTTACTGGCTGAGTGAGGGCATAGAAGTT
AAAGGTTACTGTTTTTATCCTCTATCCTTTTTTCCTTTCCTGATCAAGGTGCTCTTCTCATTTTTTCCTGAGAACCTTAGCCATCAGATG
AGGCTCCTTAGTTTATTGTGGTTGGTTGTTTTTTCTTTATAATGGCTCTGGGCTATATGCCTATATTTATAAACCAGCAGCAGGGGAAAG
ATTATATTTTATAAGAGGGAACAAATTTTCACAATTTGAAAAGCCCACATAAGTTTTCTCTTTTAAGGTAGAATCTTGTTAATTTCATTC
CAAACATCGGGGCTAACAGAGACTGGAGGCATTTCTTTTTAGGCTCTGAGACTAAATGAGAGGAAAAGAAAAGAAAAAAAAAATGATTGT
CTAACCAATTGTGAGAATTACTGTTTGAAACTTTTCAAGGCACATTGAAATACTTGAAAACTTCTCATTTATGTTATTTATGATGTTATT
TTGTACGTGTTATTATTATTATATTGTTTTATAAATGGAGGTACAGGATATCACCTGAATTATTAATGAATGCCCAGGAAGTAATTTTCT
TCTCATTCTTCTAAAACTACTGCCTTTCAAAGTGCACACACACGCGTCCACATACACTGCATTCGTTGCTCCAGTATAAATTACATGCAT
GAGCACCTTTCTGGCTTTTAAGCCAATATAATGGGCTGCAAAATGAAGACACCAGAGTGTATGCATACAAATCTCACTGTATTAAAGATG
CAGGTTTTCTAATTGTACCCTTCTTGTCTCTCTGGCAATCTTGCCCTTAATATCCCTGGAGTTCCTCATCAGTGTCATTTTCTGTTATAC
ACAGTTCCACAATTTTGTCTCTAGTTGACTTCAAATGTGTAACTTTATTGGTCTTGCCCTATTATAATTGTCATGACTTTCAGATTGTAT
CTGAACTCACAGACTGCTGTCTTACTAATAGGTCTGGAAGGTCACGCTGAATGAGAAGTAAATTATTTTATGTAATACATTTTTGAGTGT
GTTTTTCAGTTGTATTTCCCTGTTATTTCATCACTATTTCCAATGGTGAGCTTGCCTGCTCATGCTCCCTGGACAGAATACTCCTTCCTT
TTGCATGCCTGTTTCTATCATGTGCTTGATAGGCCTCAAAGCTAATGCTTCCAGTGAAACACACGCATCTTAATAATAAGGGTAAATAAA
CGCTCCATATGAAACTA

>5408_5408_1_APH1A-RGS4_APH1A_chr1_150239756_ENST00000360244_RGS4_chr1_163039042_ENST00000421743_length(amino acids)=443AA_BP=159
MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAY
YKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSGAGEAEGDRGAGTAERSSDW
LDGRSWAIKETPTGLAGRRSEDSDNIFTGEEAKYAQSRSHSSSCRISFLLANSKLLNKMCKGLAGLPASCLRSAKDMKHRLGFLLQKSDS
CEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQ
ATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNPSSCGAEKQKGAKSSADCASLVPQCA

--------------------------------------------------------------
>5408_5408_2_APH1A-RGS4_APH1A_chr1_150239756_ENST00000369109_RGS4_chr1_163039042_ENST00000421743_length(transcript)=3763nt_BP=670nt
AGGAAGTGGCGCGGACCTTCATTTGGGGTTTCGGTTCCCCCCCTTCCCCTTCCCCGGGGTCTGGGGGTGACATTGCACCGCGCCCCTCGT
GGGGTCGCGTTGCCACCCCACGCGGACTCCCCAGCTGGCGCGCCCCTCCCATTTGCCTGTCCTGGTCAGGCCCCCACCCCCCTTCCCACC
TGACCAGCCATGGGGGCTGCGGTGTTTTTCGGCTGCACTTTCGTCGCGTTCGGCCCGGCCTTCGCGCTTTTCTTGATCACTGTGGCTGGG
GACCCGCTTCGCGTTATCATCCTGGTCGCAGGGGCATTTTTCTGGCTGGTCTCCCTGCTCCTGGCCTCTGTGGTCTGGTTCATCTTGGTC
CATGTGACCGACCGGTCAGATGCCCGGCTCCAGTACGGCCTCCTGATTTTTGGTGCTGCTGTCTCTGTCCTTCTACAGGAGGTGTTCCGC
TTTGCCTACTACAAGCTGCTTAAGAAGGCAGATGAGGGGTTAGCATCGCTGAGTGAGGACGGAAGATCACCCATCTCCATCCGCCAGATG
GCCTATGTTTCTGGTCTCTCCTTCGGTATCATCAGTGGTGTCTTCTCTGTTATCAATATTTTGGCTGATGCACTTGGGCCAGGTGTGGTT
GGGATCCATGGAGACTCACCCTATTACTTCCTGACTTCAGGGGCTGGAGAGGCAGAGGGAGACAGAGGAGCTGGTACTGCAGAGCGGTCG
TCTGATTGGCTGGACGGTCGTAGCTGGGCTATAAAAGAGACCCCTACAGGCTTAGCAGGAAGACGCTCAGAGGATTCTGACAATATCTTT
ACCGGAGAAGAGGCAAAGTACGCTCAAAGCCGAAGCCACAGCTCCTCCTGCCGCATTTCTTTCCTGCTTGCGAATTCCAAGCTGTTAAAT
AAGATGTGCAAAGGGCTTGCAGGTCTGCCGGCTTCTTGCTTGAGGAGTGCAAAAGATATGAAACATCGGCTAGGTTTCCTGCTGCAAAAA
TCTGATTCCTGTGAACACAATTCTTCCCACAACAAGAAGGACAAAGTGGTTATTTGCCAGAGAGTGAGCCAAGAGGAAGTCAAGAAATGG
GCTGAATCACTGGAAAACCTGATTAGTCATGAATGTGGGCTGGCAGCTTTCAAAGCTTTCTTGAAGTCTGAATATAGTGAGGAGAATATT
GACTTCTGGATCAGCTGTGAAGAGTACAAGAAAATCAAATCACCATCTAAACTAAGTCCCAAGGCCAAAAAGATCTATAATGAATTCATC
TCAGTCCAGGCAACCAAAGAGGTGAACCTGGATTCTTGCACCAGGGAAGAGACAAGCCGGAACATGCTAGAGCCTACAATAACCTGCTTT
GATGAGGCCCAGAAGAAGATTTTCAACCTGATGGAGAAGGATTCCTACCGCCGCTTCCTCAAGTCTCGATTCTATCTTGATTTGGTCAAC
CCGTCCAGCTGTGGGGCAGAAAAGCAGAAAGGAGCCAAGAGTTCAGCAGACTGTGCTTCCCTGGTCCCTCAGTGTGCCTAATTCTCACCT
GAAGGCAGAGGGATGAAATGCCAAGACTCTATGCTCTGGAAAACCTGAGGCCAAATATTGATCTGTATTAAGCTCCAGTGCTTTATCCAC
ATTGTAGCCTAATATTCATGCTGCCTGCCATGTGTGAGTCACTTCTACGCATAAACTAGATATAGCTTTTGGTGTTTGAGTGTTCATCAG
GGTGGGACCCCATTCCAGTCCAATTTTCCTAAGTTTCTTTGAGGGTTCCATGGGAGCAAATATCTAAATAATGGCCTGGTAGGTCTGGAT
TTTCAAAGATTGTTGGCAGTTTCCTCCTCCCAACAGTTTTACCTCGGGATGGTTGGTTAGTGCATGTCACATGACATCCACATGCACATG
TATTCTGTTGGCCAGCACGTTCTCCAGACTCTAGATGTTTAGATGAGGTTGAGCTATGATATGTGCTTGTGTGTATGTCTATGTGTATAT
ATTATATATACATTAGACACACATATACATTATTTCTGTATATAGATGTCTGTGTATACATATGTATGTGTGAGTGTATGTATACACACA
CACACACACACACACACACACTTTTGCAAGAGTGATGGGAAAGACCCTAGGTGCTCATAACTAGAGTATGTGTATGTACTTACATGGGTG
TTTTGATCTCTGTTCTTTCATACTACATTTGAACAGGGCAAAATGAACTAACTGCCATGTAGGCTAAGAAAGAAATGCTAACCTGTGGAA
AGTTGGTTTTGTAAAATTCCATGGATCTTGCTGGAGAAGCATCCAAGGAACTTCATGCTTGATTTGACCACTGACAGCCTCCACCTTGAG
CACTATTCTAAGGAGCAAATACCTTAGCTCCCTTGAGCTGGTTTTCTCTGATGGCACTTTTGAGCTCCTAAGCTGCCAGCCTTCCCTTCT
TTTCCTGGGTGCTCAGGGCATGCTTATTAGCAGCTGGGTTGGTATGGAGTTGGCAGACAGGATGTTCAACTTAATGAAGAAATACAGCTA
AGGCCTTGCCAGCAACACCTGCCGTAAGTTACTGGCTGAGTGAGGGCATAGAAGTTAAAGGTTACTGTTTTTATCCTCTATCCTTTTTTC
CTTTCCTGATCAAGGTGCTCTTCTCATTTTTTCCTGAGAACCTTAGCCATCAGATGAGGCTCCTTAGTTTATTGTGGTTGGTTGTTTTTT
CTTTATAATGGCTCTGGGCTATATGCCTATATTTATAAACCAGCAGCAGGGGAAAGATTATATTTTATAAGAGGGAACAAATTTTCACAA
TTTGAAAAGCCCACATAAGTTTTCTCTTTTAAGGTAGAATCTTGTTAATTTCATTCCAAACATCGGGGCTAACAGAGACTGGAGGCATTT
CTTTTTAGGCTCTGAGACTAAATGAGAGGAAAAGAAAAGAAAAAAAAAATGATTGTCTAACCAATTGTGAGAATTACTGTTTGAAACTTT
TCAAGGCACATTGAAATACTTGAAAACTTCTCATTTATGTTATTTATGATGTTATTTTGTACGTGTTATTATTATTATATTGTTTTATAA
ATGGAGGTACAGGATATCACCTGAATTATTAATGAATGCCCAGGAAGTAATTTTCTTCTCATTCTTCTAAAACTACTGCCTTTCAAAGTG
CACACACACGCGTCCACATACACTGCATTCGTTGCTCCAGTATAAATTACATGCATGAGCACCTTTCTGGCTTTTAAGCCAATATAATGG
GCTGCAAAATGAAGACACCAGAGTGTATGCATACAAATCTCACTGTATTAAAGATGCAGGTTTTCTAATTGTACCCTTCTTGTCTCTCTG
GCAATCTTGCCCTTAATATCCCTGGAGTTCCTCATCAGTGTCATTTTCTGTTATACACAGTTCCACAATTTTGTCTCTAGTTGACTTCAA
ATGTGTAACTTTATTGGTCTTGCCCTATTATAATTGTCATGACTTTCAGATTGTATCTGAACTCACAGACTGCTGTCTTACTAATAGGTC
TGGAAGGTCACGCTGAATGAGAAGTAAATTATTTTATGTAATACATTTTTGAGTGTGTTTTTCAGTTGTATTTCCCTGTTATTTCATCAC
TATTTCCAATGGTGAGCTTGCCTGCTCATGCTCCCTGGACAGAATACTCCTTCCTTTTGCATGCCTGTTTCTATCATGTGCTTGATAGGC
CTCAAAGCTAATGCTTCCAGTGAAACACACGCATCTTAATAATAAGGGTAAATAAACGCTCCATATGAAACTA

>5408_5408_2_APH1A-RGS4_APH1A_chr1_150239756_ENST00000369109_RGS4_chr1_163039042_ENST00000421743_length(amino acids)=443AA_BP=159
MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAY
YKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSGAGEAEGDRGAGTAERSSDW
LDGRSWAIKETPTGLAGRRSEDSDNIFTGEEAKYAQSRSHSSSCRISFLLANSKLLNKMCKGLAGLPASCLRSAKDMKHRLGFLLQKSDS
CEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQ
ATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNPSSCGAEKQKGAKSSADCASLVPQCA

--------------------------------------------------------------
>5408_5408_3_APH1A-RGS4_APH1A_chr1_150239756_ENST00000414276_RGS4_chr1_163039042_ENST00000421743_length(transcript)=3570nt_BP=477nt
CTCTTCGGCTTCCGTAGAGGAAGTGGCGCGGACCTTCATTTGGGGTTTCGGTTCCCCCCCTTCCCCTTCCCCGGGGTCTGGGGGTGACAT
TGCACCGCGCCCCTCGTGGGGTCGCGTTGCCACCCCACGCGGACTCCCCAGCTGGCGCGCCCCTCCCATTTGCCTGTCCTGGTCAGGCCC
CCACCCCCCTTCCCACCTGACCAGCCATGGGGGCTGCGGTGTTTTTCGGCTGCACTTTCGTCGCGTTCGGCCCGGCCTTCGCGCTTTTCT
TGATCACTGTGGCTGGGGACCCGCTTCGCGTTATCATCCTGGTCGCAGGGAGGTGTTCCGCTTTGCCTACTACAAGCTGCTTAATTTCTG
GTCTCTCCTTCGGTATCATCAGTGGTGTCTTCTCTGTTATCAATATTTTGGCTGATGCACTTGGGCCAGGTGTGGTTGGGATCCATGGAG
ACTCACCCTATTACTTCCTGACTTCAGGGGCTGGAGAGGCAGAGGGAGACAGAGGAGCTGGTACTGCAGAGCGGTCGTCTGATTGGCTGG
ACGGTCGTAGCTGGGCTATAAAAGAGACCCCTACAGGCTTAGCAGGAAGACGCTCAGAGGATTCTGACAATATCTTTACCGGAGAAGAGG
CAAAGTACGCTCAAAGCCGAAGCCACAGCTCCTCCTGCCGCATTTCTTTCCTGCTTGCGAATTCCAAGCTGTTAAATAAGATGTGCAAAG
GGCTTGCAGGTCTGCCGGCTTCTTGCTTGAGGAGTGCAAAAGATATGAAACATCGGCTAGGTTTCCTGCTGCAAAAATCTGATTCCTGTG
AACACAATTCTTCCCACAACAAGAAGGACAAAGTGGTTATTTGCCAGAGAGTGAGCCAAGAGGAAGTCAAGAAATGGGCTGAATCACTGG
AAAACCTGATTAGTCATGAATGTGGGCTGGCAGCTTTCAAAGCTTTCTTGAAGTCTGAATATAGTGAGGAGAATATTGACTTCTGGATCA
GCTGTGAAGAGTACAAGAAAATCAAATCACCATCTAAACTAAGTCCCAAGGCCAAAAAGATCTATAATGAATTCATCTCAGTCCAGGCAA
CCAAAGAGGTGAACCTGGATTCTTGCACCAGGGAAGAGACAAGCCGGAACATGCTAGAGCCTACAATAACCTGCTTTGATGAGGCCCAGA
AGAAGATTTTCAACCTGATGGAGAAGGATTCCTACCGCCGCTTCCTCAAGTCTCGATTCTATCTTGATTTGGTCAACCCGTCCAGCTGTG
GGGCAGAAAAGCAGAAAGGAGCCAAGAGTTCAGCAGACTGTGCTTCCCTGGTCCCTCAGTGTGCCTAATTCTCACCTGAAGGCAGAGGGA
TGAAATGCCAAGACTCTATGCTCTGGAAAACCTGAGGCCAAATATTGATCTGTATTAAGCTCCAGTGCTTTATCCACATTGTAGCCTAAT
ATTCATGCTGCCTGCCATGTGTGAGTCACTTCTACGCATAAACTAGATATAGCTTTTGGTGTTTGAGTGTTCATCAGGGTGGGACCCCAT
TCCAGTCCAATTTTCCTAAGTTTCTTTGAGGGTTCCATGGGAGCAAATATCTAAATAATGGCCTGGTAGGTCTGGATTTTCAAAGATTGT
TGGCAGTTTCCTCCTCCCAACAGTTTTACCTCGGGATGGTTGGTTAGTGCATGTCACATGACATCCACATGCACATGTATTCTGTTGGCC
AGCACGTTCTCCAGACTCTAGATGTTTAGATGAGGTTGAGCTATGATATGTGCTTGTGTGTATGTCTATGTGTATATATTATATATACAT
TAGACACACATATACATTATTTCTGTATATAGATGTCTGTGTATACATATGTATGTGTGAGTGTATGTATACACACACACACACACACAC
ACACACACTTTTGCAAGAGTGATGGGAAAGACCCTAGGTGCTCATAACTAGAGTATGTGTATGTACTTACATGGGTGTTTTGATCTCTGT
TCTTTCATACTACATTTGAACAGGGCAAAATGAACTAACTGCCATGTAGGCTAAGAAAGAAATGCTAACCTGTGGAAAGTTGGTTTTGTA
AAATTCCATGGATCTTGCTGGAGAAGCATCCAAGGAACTTCATGCTTGATTTGACCACTGACAGCCTCCACCTTGAGCACTATTCTAAGG
AGCAAATACCTTAGCTCCCTTGAGCTGGTTTTCTCTGATGGCACTTTTGAGCTCCTAAGCTGCCAGCCTTCCCTTCTTTTCCTGGGTGCT
CAGGGCATGCTTATTAGCAGCTGGGTTGGTATGGAGTTGGCAGACAGGATGTTCAACTTAATGAAGAAATACAGCTAAGGCCTTGCCAGC
AACACCTGCCGTAAGTTACTGGCTGAGTGAGGGCATAGAAGTTAAAGGTTACTGTTTTTATCCTCTATCCTTTTTTCCTTTCCTGATCAA
GGTGCTCTTCTCATTTTTTCCTGAGAACCTTAGCCATCAGATGAGGCTCCTTAGTTTATTGTGGTTGGTTGTTTTTTCTTTATAATGGCT
CTGGGCTATATGCCTATATTTATAAACCAGCAGCAGGGGAAAGATTATATTTTATAAGAGGGAACAAATTTTCACAATTTGAAAAGCCCA
CATAAGTTTTCTCTTTTAAGGTAGAATCTTGTTAATTTCATTCCAAACATCGGGGCTAACAGAGACTGGAGGCATTTCTTTTTAGGCTCT
GAGACTAAATGAGAGGAAAAGAAAAGAAAAAAAAAATGATTGTCTAACCAATTGTGAGAATTACTGTTTGAAACTTTTCAAGGCACATTG
AAATACTTGAAAACTTCTCATTTATGTTATTTATGATGTTATTTTGTACGTGTTATTATTATTATATTGTTTTATAAATGGAGGTACAGG
ATATCACCTGAATTATTAATGAATGCCCAGGAAGTAATTTTCTTCTCATTCTTCTAAAACTACTGCCTTTCAAAGTGCACACACACGCGT
CCACATACACTGCATTCGTTGCTCCAGTATAAATTACATGCATGAGCACCTTTCTGGCTTTTAAGCCAATATAATGGGCTGCAAAATGAA
GACACCAGAGTGTATGCATACAAATCTCACTGTATTAAAGATGCAGGTTTTCTAATTGTACCCTTCTTGTCTCTCTGGCAATCTTGCCCT
TAATATCCCTGGAGTTCCTCATCAGTGTCATTTTCTGTTATACACAGTTCCACAATTTTGTCTCTAGTTGACTTCAAATGTGTAACTTTA
TTGGTCTTGCCCTATTATAATTGTCATGACTTTCAGATTGTATCTGAACTCACAGACTGCTGTCTTACTAATAGGTCTGGAAGGTCACGC
TGAATGAGAAGTAAATTATTTTATGTAATACATTTTTGAGTGTGTTTTTCAGTTGTATTTCCCTGTTATTTCATCACTATTTCCAATGGT
GAGCTTGCCTGCTCATGCTCCCTGGACAGAATACTCCTTCCTTTTGCATGCCTGTTTCTATCATGTGCTTGATAGGCCTCAAAGCTAATG
CTTCCAGTGAAACACACGCATCTTAATAATAAGGGTAAATAAACGCTCCATATGAAACTA

>5408_5408_3_APH1A-RGS4_APH1A_chr1_150239756_ENST00000414276_RGS4_chr1_163039042_ENST00000421743_length(amino acids)=373AA_BP=89
MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGRCSALPTTSCLISGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTS
GAGEAEGDRGAGTAERSSDWLDGRSWAIKETPTGLAGRRSEDSDNIFTGEEAKYAQSRSHSSSCRISFLLANSKLLNKMCKGLAGLPASC
LRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIK
SPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNPSSCGAEKQKGAK
SSADCASLVPQCA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for APH1A-RGS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for APH1A-RGS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for APH1A-RGS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0005586Bipolar Disorder5PSYGENET
TgeneC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneC0014175Endometriosis1CTD_human
TgeneC0269102Endometrioma1CTD_human