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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EMC4-RCC2 (FusionGDB2 ID:HG51234TG55920)

Fusion Gene Summary for EMC4-RCC2

check button Fusion gene summary
Fusion gene informationFusion gene name: EMC4-RCC2
Fusion gene ID: hg51234tg55920
HgeneTgene
Gene symbol

EMC4

RCC2

Gene ID

51234

55920

Gene nameER membrane protein complex subunit 4regulator of chromosome condensation 2
SynonymsPIG17|TMEM85TD-60
Cytomap('EMC4')('RCC2')

15q14

1p36.13

Type of geneprotein-codingprotein-coding
DescriptionER membrane protein complex subunit 4cell proliferation-inducing gene 17 proteintransmembrane protein 85protein RCC2RCC1-like protein TD-60epididymis secretory sperm binding proteintelophase disk protein of 60 kDa
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000249209, ENST00000267750, 
ENST00000557879, ENST00000559078, 
ENST00000559421, 
Fusion gene scores* DoF score2 X 1 X 1=210 X 7 X 4=280
# samples 211
** MAII scorelog2(2/2*10)=3.32192809488736log2(11/280*10)=-1.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EMC4 [Title/Abstract] AND RCC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEMC4(34520047)-RCC2(17739674), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRCC2

GO:0007229

integrin-mediated signaling pathway

19738201

TgeneRCC2

GO:0048041

focal adhesion assembly

19738201


check buttonFusion gene breakpoints across EMC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RCC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8534-01AEMC4chr15

34520047

+RCC2chr1

17739674

-


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Fusion Gene ORF analysis for EMC4-RCC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000249209ENST00000375433EMC4chr15

34520047

+RCC2chr1

17739674

-
5CDS-intronENST00000249209ENST00000474892EMC4chr15

34520047

+RCC2chr1

17739674

-
5CDS-intronENST00000267750ENST00000375433EMC4chr15

34520047

+RCC2chr1

17739674

-
5CDS-intronENST00000267750ENST00000474892EMC4chr15

34520047

+RCC2chr1

17739674

-
In-frameENST00000249209ENST00000375436EMC4chr15

34520047

+RCC2chr1

17739674

-
In-frameENST00000267750ENST00000375436EMC4chr15

34520047

+RCC2chr1

17739674

-
intron-3CDSENST00000557879ENST00000375436EMC4chr15

34520047

+RCC2chr1

17739674

-
intron-3CDSENST00000559078ENST00000375436EMC4chr15

34520047

+RCC2chr1

17739674

-
intron-3CDSENST00000559421ENST00000375436EMC4chr15

34520047

+RCC2chr1

17739674

-
intron-intronENST00000557879ENST00000375433EMC4chr15

34520047

+RCC2chr1

17739674

-
intron-intronENST00000557879ENST00000474892EMC4chr15

34520047

+RCC2chr1

17739674

-
intron-intronENST00000559078ENST00000375433EMC4chr15

34520047

+RCC2chr1

17739674

-
intron-intronENST00000559078ENST00000474892EMC4chr15

34520047

+RCC2chr1

17739674

-
intron-intronENST00000559421ENST00000375433EMC4chr15

34520047

+RCC2chr1

17739674

-
intron-intronENST00000559421ENST00000474892EMC4chr15

34520047

+RCC2chr1

17739674

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000267750EMC4chr1534520047+ENST00000375436RCC2chr117739674-3163471116832238
ENST00000249209EMC4chr1534520047+ENST00000375436RCC2chr117739674-3149457102818238

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000267750ENST00000375436EMC4chr1534520047+RCC2chr117739674-0.0168711360.98312885
ENST00000249209ENST00000375436EMC4chr1534520047+RCC2chr117739674-0.0176093060.98239076

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Fusion Genomic Features for EMC4-RCC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for EMC4-RCC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:34520047/chr1:17739674)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEMC4chr15:34520047chr1:17739674ENST00000249209+342_66118150.0Topological domainCytoplasmic
HgeneEMC4chr15:34520047chr1:17739674ENST00000249209+3488_98118150.0Topological domainLumenal
HgeneEMC4chr15:34520047chr1:17739674ENST00000267750+352_66118184.0Topological domainCytoplasmic
HgeneEMC4chr15:34520047chr1:17739674ENST00000267750+3588_98118184.0Topological domainLumenal
HgeneEMC4chr15:34520047chr1:17739674ENST00000249209+3467_87118150.0TransmembraneHelical
HgeneEMC4chr15:34520047chr1:17739674ENST00000249209+3499_120118150.0TransmembraneHelical
HgeneEMC4chr15:34520047chr1:17739674ENST00000267750+3567_87118184.0TransmembraneHelical
HgeneEMC4chr15:34520047chr1:17739674ENST00000267750+3599_120118184.0TransmembraneHelical
TgeneRCC2chr15:34520047chr1:17739674ENST00000375433712403_447402523.0RepeatNote=RCC1 6
TgeneRCC2chr15:34520047chr1:17739674ENST00000375433712448_501402523.0RepeatNote=RCC1 7
TgeneRCC2chr15:34520047chr1:17739674ENST00000375436813403_447402523.0RepeatNote=RCC1 6
TgeneRCC2chr15:34520047chr1:17739674ENST00000375436813448_501402523.0RepeatNote=RCC1 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEMC4chr15:34520047chr1:17739674ENST00000249209+34121_127118150.0Topological domainCytoplasmic
HgeneEMC4chr15:34520047chr1:17739674ENST00000249209+34149_183118150.0Topological domainLumenal
HgeneEMC4chr15:34520047chr1:17739674ENST00000267750+35121_127118184.0Topological domainCytoplasmic
HgeneEMC4chr15:34520047chr1:17739674ENST00000267750+35149_183118184.0Topological domainLumenal
HgeneEMC4chr15:34520047chr1:17739674ENST00000249209+34128_148118150.0TransmembraneHelical
HgeneEMC4chr15:34520047chr1:17739674ENST00000267750+35128_148118184.0TransmembraneHelical
TgeneRCC2chr15:34520047chr1:17739674ENST00000375433712103_165402523.0RepeatNote=RCC1 1
TgeneRCC2chr15:34520047chr1:17739674ENST00000375433712168_219402523.0RepeatNote=RCC1 2
TgeneRCC2chr15:34520047chr1:17739674ENST00000375433712221_271402523.0RepeatNote=RCC1 3
TgeneRCC2chr15:34520047chr1:17739674ENST00000375433712273_347402523.0RepeatNote=RCC1 4
TgeneRCC2chr15:34520047chr1:17739674ENST00000375433712348_401402523.0RepeatNote=RCC1 5
TgeneRCC2chr15:34520047chr1:17739674ENST00000375436813103_165402523.0RepeatNote=RCC1 1
TgeneRCC2chr15:34520047chr1:17739674ENST00000375436813168_219402523.0RepeatNote=RCC1 2
TgeneRCC2chr15:34520047chr1:17739674ENST00000375436813221_271402523.0RepeatNote=RCC1 3
TgeneRCC2chr15:34520047chr1:17739674ENST00000375436813273_347402523.0RepeatNote=RCC1 4
TgeneRCC2chr15:34520047chr1:17739674ENST00000375436813348_401402523.0RepeatNote=RCC1 5


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Fusion Gene Sequence for EMC4-RCC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>26381_26381_1_EMC4-RCC2_EMC4_chr15_34520047_ENST00000249209_RCC2_chr1_17739674_ENST00000375436_length(transcript)=3149nt_BP=457nt
AGTGCATTTGCAGAGTGAGACAAAGCGGAGAACGCTGGTGGGCCTGTTGTGGAGTACGCTTTGGACTGAGAAGCATCGAGGCTATAGGAC
GCAGCTGTTGCCATGACGGCCCAGGGGGGCCTGGTGGCTAACCGAGGCCGGCGCTTCAAGTGGGCCATTGAGCTAAGCGGGCCTGGAGGA
GGCAGCAGGGGTCGAAGTGACCGGGGCAGTGGCCAGGGAGACTCGCTCTACCCAGTCGGTTACTTGGACAAGCAAGTGCCTGATACCAGC
GTGCAAGAGACAGACCGGATCCTGGTGGAGAAGCGCTGCTGGGACATCGCCTTGGGTCCCCTCAAACAGATTCCCATGAATCTCTTCATC
ATGTACATGGCAGGCAATACTATCTCCATCTTCCCTACTATGATGGTGTGTATGATGGCCTGGCGACCCATTCAGGCACTTATGGCCATT
TCAGCCAGTGGTCTGTTTTTCTGGGGGGCCACCAACACCTCCCGTGAATCTACCATGTACCCAAAAGCAGTGCAGGACCTCTGCGGCTGG
AGAATCCGGAGCCTGGCTTGTGGGAAGAGCAGCATCATTGTGGCCGCCGATGAGAGCACCATCAGCTGGGGTCCGTCACCGACCTTTGGG
GAACTGGGCTACGGGGACCACAAGCCCAAGTCTTCCACTGCAGCCCAGGAGGTAAAGACTCTGGATGGCATTTTCTCAGAGCAGGTCGCC
ATGGGCTACTCACACTCCTTGGTGATAGCAAGAGATGAAAGTGAGACTGAGAAAGAGAAGATCAAGAAACTGCCAGAATACAACCCCCGA
ACCCTCTGATGCTCCCGGAGACTCCTCCGACTCCACACCTCTCGCGGCAGCTGTCATTTCCATGTGCACTGGGACGGGAAGTCAAACGAG
GAATTTAAAAAAGCAAAAGTTGACCGAAGGTGCATTTTTGTTTAGACTCCCTGAGGTTCCGTTTTACACATGATCCAACGTTAACTACCT
TTTTTTCTGTATGCTTTCCAAAGTCCTTTTTTTTCCCTTAATGTTGAATTAAAATACTTGCTCATAGTTGATTTACCATTCCTACAAAAG
AGGCAGAAACTTTGAGCAATCTAGGTTTTTTTTTTTTTTAAGTTTTTTCTTTCTTCCTCTCCTGAATACACTCCCCAAAACACCCCTTTC
CAGTTACAATTAGCATCGTGATCCAAGCAGATGCCACATGGAAGAGGAATCGCCATTTACTCAGAAAAAATGTCCCTTACAGGAACCGGC
AGCAGCTAGGCAGTCACCGGCCCGCCTCCATCCAAAATCACGCTCGCGTGCTTCGGAAGCATCCGGGTCACTCCTTCTCCGCTTTTTCTT
GCAGATGGGCCTAGGCCGGTGTCGGTTCTGTTTCTCCCCTTGGCTGCCTGTACGCCCACAGCCTTCTGGCTGCGACATTATAGAATCGGC
CGTGTCCCCCCTGGTGGGGGATTGGGGATCTGTGTTTAGCCATTTATATCTACTTTAGCTGTTAAAGAGGTCCAAATGAAAATCAGGTGA
TTGTGGAACCATGGGGACTTGGGGGTGGGGCAGAGGTGGGAACATTTGTATCAGTTGAGTCAGCTTGGTGGCTCCCTGTGGAGCCAGGGC
TGAGCCTTGTCACGCGCACTCGCCAATTAAGAGATGGACCAGCCAGCAGTCAAGTGCATTCTCCAGTCCTTGCAAGAAGGATCAGCCCTT
TCTGTGCCAGCCTCGATCGCCTTGTGCTTTGGTCTCTTTTTCTCCCCCCCGCCTGGATCCTGCCTCGCGCGGGCCGTCCTGTTGCTGAGA
CTCGGGGTACCGTTCTGCTGACCCAGCTCCCTTTAGTCACGTTTGCTTGGCTCTGGTACCAAATAGTTGGGATTACCGAAGAGTCCCCTT
CCTTGCGTGTCAGCACGGATGCTGTGACTGCCACCTGCGTCCTCGTCAAGTGCCCGAGCTCGCCGCCGTGTGTGCTGCGCTGAGTGAGTT
ATGAGGTGCCTTTCCCGGAACCCTCCTCTCGCCTGGACCCAAGAGAGGCGACAGCTGTGGCTGGGGCTCTTGGTTTCCAGAGGGTCTGGA
CTGGTTTGGGTGCTTTAAAATAGATATTTAGTTCAGTGGTGCTTATGGGGGAGATGGGACTAGAACTTAAGTGTGAGACTTGGGTGGATG
GGAAAGTTAAATATTGGTCTCTTCAAGTTTTTTTTTTCTTTTGCTTTGTTACCACTTGTCACTGTCTCCATGTTAAAATGCCAAAAATGA
TGTAGTTGTTGTTGCTTTTTTCCCTATTTTCCACCCCAGTCGCTCCTTACCGTGACTCCTGCCCTTGGAGGGCATGTAGCAGTGTCTGTC
CTGCCAGTCCCAAGGCCCTGTGGGAGGAGACTGGCCTGCATCTCTCTAAGACTTAGTCTGACGCCACGCGCATCTCTTGTTCTGTGTTCA
ATCAGTAGTCCAGGGGAGAAGCTTCTGCTACTTCAGAGCTTTGCTAAACTAACCTAATTTGTCCAAATCACCCCAAAACCACCATCTCTG
ACGTAAGCTTCCATGCGACAGCCTGATCCGTTTCCCTGGACAGGTCTCTTTCCTGGAATGCAGCCCAGGCACCTGTGCTCCTGGCACCCT
TGAGGTCTCTCCTTTGAGCCGTGGTCACCGAGAGGGTTGAGGACGCAGCACCCGAGGTCCCAGCCTTTGCAGGAGCCTCCCTGGGCTTAG
CTGGACTTAGATCTTCGGTGGCCTCATGTAAACGTGGCAGCCAGCCTCTTCTAGAACCCTAGCCCAGGGACTGGAGCAGGAAAGGGACCT
TCAAAGTGAAGACTGCCTTGTCCCGCAGCTCCTTCTGGCTTAGATTGAAAAATGGGCTTCCTAATGGGTTAAATCCTTTAAAACAAGGAG
TTGTGGGGGAAGGGTGTCGTGCACTCCTAGAGAAAGGTACACAGTTGCCCGGTTGGGAATGTGCTTGGCGCTGACCCTGCGGGCATCTGA
CTGGTCTTCCAGCTCAGGAAAAAGAATTTGAAAGAGGCTTAGCGTGAAGGGGAATCAAAGAGGAGGTTGTGATTTGGTCGAAGGTGCCTG
GTTTAGTGCTGTAATTGTCTTATTATTTTTTTTATATATATATTTCTTGGAGTAAACATTTTAAATAAACAACAACATTGTCTACTGTC

>26381_26381_1_EMC4-RCC2_EMC4_chr15_34520047_ENST00000249209_RCC2_chr1_17739674_ENST00000375436_length(amino acids)=238AA_BP=112
MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMA
GNTISIFPTMMVCMMAWRPIQALMAISASGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGY
GDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNPRTL

--------------------------------------------------------------
>26381_26381_2_EMC4-RCC2_EMC4_chr15_34520047_ENST00000267750_RCC2_chr1_17739674_ENST00000375436_length(transcript)=3163nt_BP=471nt
ATTCACGCGCCGGAAGTGCATTTGCAGAGTGAGACAAAGCGGAGAACGCTGGTGGGCCTGTTGTGGAGTACGCTTTGGACTGAGAAGCAT
CGAGGCTATAGGACGCAGCTGTTGCCATGACGGCCCAGGGGGGCCTGGTGGCTAACCGAGGCCGGCGCTTCAAGTGGGCCATTGAGCTAA
GCGGGCCTGGAGGAGGCAGCAGGGGTCGAAGTGACCGGGGCAGTGGCCAGGGAGACTCGCTCTACCCAGTCGGTTACTTGGACAAGCAAG
TGCCTGATACCAGCGTGCAAGAGACAGACCGGATCCTGGTGGAGAAGCGCTGCTGGGACATCGCCTTGGGTCCCCTCAAACAGATTCCCA
TGAATCTCTTCATCATGTACATGGCAGGCAATACTATCTCCATCTTCCCTACTATGATGGTGTGTATGATGGCCTGGCGACCCATTCAGG
CACTTATGGCCATTTCAGCCAGTGGTCTGTTTTTCTGGGGGGCCACCAACACCTCCCGTGAATCTACCATGTACCCAAAAGCAGTGCAGG
ACCTCTGCGGCTGGAGAATCCGGAGCCTGGCTTGTGGGAAGAGCAGCATCATTGTGGCCGCCGATGAGAGCACCATCAGCTGGGGTCCGT
CACCGACCTTTGGGGAACTGGGCTACGGGGACCACAAGCCCAAGTCTTCCACTGCAGCCCAGGAGGTAAAGACTCTGGATGGCATTTTCT
CAGAGCAGGTCGCCATGGGCTACTCACACTCCTTGGTGATAGCAAGAGATGAAAGTGAGACTGAGAAAGAGAAGATCAAGAAACTGCCAG
AATACAACCCCCGAACCCTCTGATGCTCCCGGAGACTCCTCCGACTCCACACCTCTCGCGGCAGCTGTCATTTCCATGTGCACTGGGACG
GGAAGTCAAACGAGGAATTTAAAAAAGCAAAAGTTGACCGAAGGTGCATTTTTGTTTAGACTCCCTGAGGTTCCGTTTTACACATGATCC
AACGTTAACTACCTTTTTTTCTGTATGCTTTCCAAAGTCCTTTTTTTTCCCTTAATGTTGAATTAAAATACTTGCTCATAGTTGATTTAC
CATTCCTACAAAAGAGGCAGAAACTTTGAGCAATCTAGGTTTTTTTTTTTTTTAAGTTTTTTCTTTCTTCCTCTCCTGAATACACTCCCC
AAAACACCCCTTTCCAGTTACAATTAGCATCGTGATCCAAGCAGATGCCACATGGAAGAGGAATCGCCATTTACTCAGAAAAAATGTCCC
TTACAGGAACCGGCAGCAGCTAGGCAGTCACCGGCCCGCCTCCATCCAAAATCACGCTCGCGTGCTTCGGAAGCATCCGGGTCACTCCTT
CTCCGCTTTTTCTTGCAGATGGGCCTAGGCCGGTGTCGGTTCTGTTTCTCCCCTTGGCTGCCTGTACGCCCACAGCCTTCTGGCTGCGAC
ATTATAGAATCGGCCGTGTCCCCCCTGGTGGGGGATTGGGGATCTGTGTTTAGCCATTTATATCTACTTTAGCTGTTAAAGAGGTCCAAA
TGAAAATCAGGTGATTGTGGAACCATGGGGACTTGGGGGTGGGGCAGAGGTGGGAACATTTGTATCAGTTGAGTCAGCTTGGTGGCTCCC
TGTGGAGCCAGGGCTGAGCCTTGTCACGCGCACTCGCCAATTAAGAGATGGACCAGCCAGCAGTCAAGTGCATTCTCCAGTCCTTGCAAG
AAGGATCAGCCCTTTCTGTGCCAGCCTCGATCGCCTTGTGCTTTGGTCTCTTTTTCTCCCCCCCGCCTGGATCCTGCCTCGCGCGGGCCG
TCCTGTTGCTGAGACTCGGGGTACCGTTCTGCTGACCCAGCTCCCTTTAGTCACGTTTGCTTGGCTCTGGTACCAAATAGTTGGGATTAC
CGAAGAGTCCCCTTCCTTGCGTGTCAGCACGGATGCTGTGACTGCCACCTGCGTCCTCGTCAAGTGCCCGAGCTCGCCGCCGTGTGTGCT
GCGCTGAGTGAGTTATGAGGTGCCTTTCCCGGAACCCTCCTCTCGCCTGGACCCAAGAGAGGCGACAGCTGTGGCTGGGGCTCTTGGTTT
CCAGAGGGTCTGGACTGGTTTGGGTGCTTTAAAATAGATATTTAGTTCAGTGGTGCTTATGGGGGAGATGGGACTAGAACTTAAGTGTGA
GACTTGGGTGGATGGGAAAGTTAAATATTGGTCTCTTCAAGTTTTTTTTTTCTTTTGCTTTGTTACCACTTGTCACTGTCTCCATGTTAA
AATGCCAAAAATGATGTAGTTGTTGTTGCTTTTTTCCCTATTTTCCACCCCAGTCGCTCCTTACCGTGACTCCTGCCCTTGGAGGGCATG
TAGCAGTGTCTGTCCTGCCAGTCCCAAGGCCCTGTGGGAGGAGACTGGCCTGCATCTCTCTAAGACTTAGTCTGACGCCACGCGCATCTC
TTGTTCTGTGTTCAATCAGTAGTCCAGGGGAGAAGCTTCTGCTACTTCAGAGCTTTGCTAAACTAACCTAATTTGTCCAAATCACCCCAA
AACCACCATCTCTGACGTAAGCTTCCATGCGACAGCCTGATCCGTTTCCCTGGACAGGTCTCTTTCCTGGAATGCAGCCCAGGCACCTGT
GCTCCTGGCACCCTTGAGGTCTCTCCTTTGAGCCGTGGTCACCGAGAGGGTTGAGGACGCAGCACCCGAGGTCCCAGCCTTTGCAGGAGC
CTCCCTGGGCTTAGCTGGACTTAGATCTTCGGTGGCCTCATGTAAACGTGGCAGCCAGCCTCTTCTAGAACCCTAGCCCAGGGACTGGAG
CAGGAAAGGGACCTTCAAAGTGAAGACTGCCTTGTCCCGCAGCTCCTTCTGGCTTAGATTGAAAAATGGGCTTCCTAATGGGTTAAATCC
TTTAAAACAAGGAGTTGTGGGGGAAGGGTGTCGTGCACTCCTAGAGAAAGGTACACAGTTGCCCGGTTGGGAATGTGCTTGGCGCTGACC
CTGCGGGCATCTGACTGGTCTTCCAGCTCAGGAAAAAGAATTTGAAAGAGGCTTAGCGTGAAGGGGAATCAAAGAGGAGGTTGTGATTTG
GTCGAAGGTGCCTGGTTTAGTGCTGTAATTGTCTTATTATTTTTTTTATATATATATTTCTTGGAGTAAACATTTTAAATAAACAACAAC
ATTGTCTACTGTC

>26381_26381_2_EMC4-RCC2_EMC4_chr15_34520047_ENST00000267750_RCC2_chr1_17739674_ENST00000375436_length(amino acids)=238AA_BP=112
MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMA
GNTISIFPTMMVCMMAWRPIQALMAISASGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGY
GDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNPRTL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EMC4-RCC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EMC4-RCC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EMC4-RCC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource