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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:COMMD10-AP3S1 (FusionGDB2 ID:HG51397TG1176)

Fusion Gene Summary for COMMD10-AP3S1

check button Fusion gene summary
Fusion gene informationFusion gene name: COMMD10-AP3S1
Fusion gene ID: hg51397tg1176
HgeneTgene
Gene symbol

COMMD10

AP3S1

Gene ID

51397

1176

Gene nameCOMM domain containing 10adaptor related protein complex 3 subunit sigma 1
SynonymsPTD002CLAPS3|Sigma3A
Cytomap('COMMD10')('AP3S1')

5q23.1

5q22.3-q23.1

Type of geneprotein-codingprotein-coding
DescriptionCOMM domain-containing protein 10AP-3 complex subunit sigma-1adapter-related protein complex 3 subunit sigma-1adaptor related protein complex 3 sigma 1 subunitclathrin adaptor complex AP3, sigma-3A subunitclathrin-associated/assembly/adapter protein, small 3clathrin-associated/assem
Modification date2020031320200320
UniProtAcc

Q9Y6G5

Q92572

Ensembl transtripts involved in fusion geneENST00000274458, ENST00000515539, 
ENST00000503424, 		ENST00000503424, 
ENST00000274458, ENST00000515539, 
Fusion gene scores* DoF score11 X 9 X 8=7926 X 8 X 7=336
# samples 1510
** MAII scorelog2(15/792*10)=-2.40053792958373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COMMD10 [Title/Abstract] AND AP3S1 [Title/Abstract] AND fusion [Title/Abstract]

Common fusion transcripts identified in colorectal cancer cell lines by high-throughput RNA sequencing (pmid: 24151535)
Most frequent breakpointCOMMD10(115428397)-AP3S1(115230784), # samples:6
Anticipated loss of major functional domain due to fusion event.AP3S1-COMMD10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AP3S1-COMMD10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
COMMD10-AP3S1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
COMMD10-AP3S1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across COMMD10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across AP3S1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-2F-A9KT-01ACOMMD10chr5

115428397

-AP3S1chr5

115230784

+
ChimerDB4BLCATCGA-GV-A3QI-01ACOMMD10chr5

115428397

-AP3S1chr5

115230784

+
ChimerDB4LGGTCGA-DB-5273-01ACOMMD10chr5

115428397

-AP3S1chr5

115230784

+
ChimerDB4LGGTCGA-DH-A7US-01ACOMMD10chr5

115428397

-AP3S1chr5

115230784

+
ChimerDB4LGGTCGA-DH-A7USCOMMD10chr5

115428397

+AP3S1chr5

115230783

+
ChimerDB4LUADTCGA-55-A490COMMD10chr5

115469875

+AP3S1chr5

115202367

+
ChimerDB4Non-CancerERR315443COMMD10chr5

115428397

+AP3S1chr5

115230784

+
ChimerDB4STADTCGA-CG-5721-01ACOMMD10chr5

115469875

+AP3S1chr5

115249059

+
ChimerDB4UCECTCGA-D1-A0ZR-01ACOMMD10chr5

115428397

+AP3S1chr5

115230784

+
ChimerKB4..COMMD10chr5

115428397

+AP3S1chr5

115230783

+


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Fusion Gene ORF analysis for COMMD10-AP3S1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000274458ENST00000505423COMMD10chr5

115469875

+AP3S1chr5

115249059

+
5CDS-3UTRENST00000515539ENST00000505423COMMD10chr5

115469875

+AP3S1chr5

115249059

+
5CDS-intronENST00000274458ENST00000505423COMMD10chr5

115469875

+AP3S1chr5

115202367

+
5CDS-intronENST00000515539ENST00000505423COMMD10chr5

115469875

+AP3S1chr5

115202367

+
In-frameENST00000274458ENST00000316788COMMD10chr5

115428397

+AP3S1chr5

115230783

+
In-frameENST00000274458ENST00000316788COMMD10chr5

115469875

+AP3S1chr5

115202367

+
In-frameENST00000274458ENST00000316788COMMD10chr5

115428397

+AP3S1chr5

115230784

+
In-frameENST00000274458ENST00000316788COMMD10chr5

115469875

+AP3S1chr5

115249059

+
In-frameENST00000274458ENST00000505423COMMD10chr5

115428397

+AP3S1chr5

115230783

+
In-frameENST00000274458ENST00000505423COMMD10chr5

115428397

+AP3S1chr5

115230784

+
In-frameENST00000515539ENST00000316788COMMD10chr5

115428397

+AP3S1chr5

115230783

+
In-frameENST00000515539ENST00000316788COMMD10chr5

115469875

+AP3S1chr5

115202367

+
In-frameENST00000515539ENST00000316788COMMD10chr5

115428397

+AP3S1chr5

115230784

+
In-frameENST00000515539ENST00000316788COMMD10chr5

115469875

+AP3S1chr5

115249059

+
In-frameENST00000515539ENST00000505423COMMD10chr5

115428397

+AP3S1chr5

115230783

+
In-frameENST00000515539ENST00000505423COMMD10chr5

115428397

+AP3S1chr5

115230784

+
intron-3CDSENST00000503424ENST00000316788COMMD10chr5

115428397

+AP3S1chr5

115230783

+
intron-3CDSENST00000503424ENST00000316788COMMD10chr5

115469875

+AP3S1chr5

115202367

+
intron-3CDSENST00000503424ENST00000316788COMMD10chr5

115428397

+AP3S1chr5

115230784

+
intron-3CDSENST00000503424ENST00000316788COMMD10chr5

115469875

+AP3S1chr5

115249059

+
intron-3CDSENST00000503424ENST00000505423COMMD10chr5

115428397

+AP3S1chr5

115230783

+
intron-3CDSENST00000503424ENST00000505423COMMD10chr5

115428397

+AP3S1chr5

115230784

+
intron-3UTRENST00000503424ENST00000505423COMMD10chr5

115469875

+AP3S1chr5

115249059

+
intron-intronENST00000503424ENST00000505423COMMD10chr5

115469875

+AP3S1chr5

115202367

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000274458COMMD10chr5115428397+ENST00000316788AP3S1chr5115230783+136146114769251
ENST00000274458COMMD10chr5115428397+ENST00000505423AP3S1chr5115230783+107246114661215
ENST00000515539COMMD10chr5115428397+ENST00000316788AP3S1chr5115230783+1391491134799221
ENST00000515539COMMD10chr5115428397+ENST00000505423AP3S1chr5115230783+1102491134691185
ENST00000274458COMMD10chr5115428397+ENST00000316788AP3S1chr5115230784+136146114769251
ENST00000274458COMMD10chr5115428397+ENST00000505423AP3S1chr5115230784+107246114661215
ENST00000515539COMMD10chr5115428397+ENST00000316788AP3S1chr5115230784+1391491134799221
ENST00000515539COMMD10chr5115428397+ENST00000505423AP3S1chr5115230784+1102491134691185
ENST00000274458COMMD10chr5115428397+ENST00000316788AP3S1chr5115230783+136146114769251
ENST00000274458COMMD10chr5115428397+ENST00000505423AP3S1chr5115230783+107246114661215
ENST00000515539COMMD10chr5115428397+ENST00000316788AP3S1chr5115230783+1391491134799221
ENST00000515539COMMD10chr5115428397+ENST00000505423AP3S1chr5115230783+1102491134691185
ENST00000274458COMMD10chr5115469875+ENST00000316788AP3S1chr5115202367+1676572141084356
ENST00000515539COMMD10chr5115469875+ENST00000316788AP3S1chr5115202367+17066021341114326
ENST00000274458COMMD10chr5115469875+ENST00000316788AP3S1chr5115249059+129257214700228
ENST00000515539COMMD10chr5115469875+ENST00000316788AP3S1chr5115249059+1322602134730198

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000274458ENST00000316788COMMD10chr5115428397+AP3S1chr5115230784+0.000740040.99926
ENST00000274458ENST00000505423COMMD10chr5115428397+AP3S1chr5115230784+0.0016220590.9983779
ENST00000515539ENST00000316788COMMD10chr5115428397+AP3S1chr5115230784+0.000877290.9991227
ENST00000515539ENST00000505423COMMD10chr5115428397+AP3S1chr5115230784+0.0022496810.99775034
ENST00000274458ENST00000316788COMMD10chr5115428397+AP3S1chr5115230783+0.000740040.99926
ENST00000274458ENST00000505423COMMD10chr5115428397+AP3S1chr5115230783+0.0016220590.9983779
ENST00000515539ENST00000316788COMMD10chr5115428397+AP3S1chr5115230783+0.000877290.9991227
ENST00000515539ENST00000505423COMMD10chr5115428397+AP3S1chr5115230783+0.0022496810.99775034
ENST00000274458ENST00000316788COMMD10chr5115469875+AP3S1chr5115202367+0.000452880.99954706
ENST00000515539ENST00000316788COMMD10chr5115469875+AP3S1chr5115202367+0.0004243620.9995757
ENST00000274458ENST00000316788COMMD10chr5115469875+AP3S1chr5115249059+0.001259940.99874014
ENST00000515539ENST00000316788COMMD10chr5115469875+AP3S1chr5115249059+0.001287170.9987129

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Fusion Genomic Features for COMMD10-AP3S1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
COMMD10chr5115469875+AP3S1chr5115249058+0.0001185430.9998814
COMMD10chr5115428397+AP3S1chr5115230783+8.28E-050.99991715
COMMD10chr5115469875+AP3S1chr5115202366+4.10E-050.999959
COMMD10chr5115469875+AP3S1chr5115249058+0.0001185430.9998814
COMMD10chr5115428397+AP3S1chr5115230783+8.28E-050.99991715
COMMD10chr5115469875+AP3S1chr5115202366+4.10E-050.999959

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for COMMD10-AP3S1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:115428397/chr5:115230784)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COMMD10

Q9Y6G5

AP3S1

Q92572

FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). {ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}.FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOMMD10chr5:115428397chr5:115230783ENST00000274458+47133_202133203.0DomainCOMM
HgeneCOMMD10chr5:115428397chr5:115230784ENST00000274458+47133_202133203.0DomainCOMM
HgeneCOMMD10chr5:115469875chr5:115202367ENST00000274458+57133_202170203.0DomainCOMM
HgeneCOMMD10chr5:115469875chr5:115249059ENST00000274458+57133_202170203.0DomainCOMM


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Fusion Gene Sequence for COMMD10-AP3S1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>18503_18503_1_COMMD10-AP3S1_COMMD10_chr5_115428397_ENST00000274458_AP3S1_chr5_115230783_ENST00000316788_length(transcript)=1361nt_BP=461nt
GCGGCCGCCATTGGCTGGGTTCGGCGCAGCTAACAGACGGCGGCAGTGCGAGAAAGCCGAAGATGGCGGTCCCCGCGGCGCTGATCCTAC
GGGAGAGCCCCAGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTTCCACGGTTGCTCACTCGGATTCTTCAAA
AACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACC
TAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTC
ATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGG
CTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGGATTTGATTTTCCATGTAGACAAGGTTCACA
ATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACAAATATGAATGAGATTGTTACACAAATTGATGCACAAAATAAGCTGG
AAAAATCTGAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCCCAAGAAATATTA
ACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAAAGGCCACTCCCAGGTAAAATCCAGGGGGAA
GAGTCATCTAAGTTTACCATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTTTTGCTCTTGGATTTAAGTCAAGGTACTGTA
TAGAAGTTGTGTAAAATCAGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTAAAGAAATTGAGTAGTTCCTATGTGATTTTT
TTTTTTCTTTTCTAAACTGCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCTACTACAGTGTTTTAAAAAGTGTTTCAGATA
TTTCTCTAATTATGTACAACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCATTCCTTAATTCCTTCTGCTATATGTCACACA
GTTGTTATTTGGAGAACCAAGTATGTATTGCATGAAAACATTATGACTTTTTTCTCTTAGTTTAAATAAACTCCAAGGTAACTGGACTTC
TAAAGCACCTTTCTGTTTGCCTGATATCTACTTTAGCAATAATTTTTTTTACAACCCTCTGACTCAACAAAGTAAATAAAAGTATATTTT
ATCACTATTAA

>18503_18503_1_COMMD10-AP3S1_COMMD10_chr5_115428397_ENST00000274458_AP3S1_chr5_115230783_ENST00000316788_length(amino acids)=251AA_BP=149
MGSAQLTDGGSARKPKMAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLET
ISFILEQAVYHNVKPAALQQQLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKVFVETLDKCFENVCELDLIFHVDKVHNILAE
MVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK

--------------------------------------------------------------
>18503_18503_2_COMMD10-AP3S1_COMMD10_chr5_115428397_ENST00000274458_AP3S1_chr5_115230783_ENST00000505423_length(transcript)=1072nt_BP=461nt
GCGGCCGCCATTGGCTGGGTTCGGCGCAGCTAACAGACGGCGGCAGTGCGAGAAAGCCGAAGATGGCGGTCCCCGCGGCGCTGATCCTAC
GGGAGAGCCCCAGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTTCCACGGTTGCTCACTCGGATTCTTCAAA
AACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACC
TAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTC
ATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGG
CTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGGATTTGATTTTCCATGTAGACAAGGCTGGCT
TAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCCCAAGAAATATTAACATTGGTGACATCAGTA
TAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAAAGGCCACTCCCAGGTAAAATCCAGGGGGAAGAGTCATCTAAGTTTACC
ATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTTTTGCTCTTGGATTTAAGTCAAGGTACTGTATAGAAGTTGTGTAAAATC
AGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTAAAGAAATTGAGTAGTTCCTATGTGATTTTTTTTTTTCTTTTCTAAACT
GCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCTACTACAGTGTTTTAAAAAGTGTTTCAGATATTTCTCTAATTATGTACA
ACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCATTCCTTAATTCCTTCTGCTATATGTCACACAGTTGTTATTT

>18503_18503_2_COMMD10-AP3S1_COMMD10_chr5_115428397_ENST00000274458_AP3S1_chr5_115230783_ENST00000505423_length(amino acids)=215AA_BP=149
MGSAQLTDGGSARKPKMAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLET
ISFILEQAVYHNVKPAALQQQLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKVFVETLDKCFENVCELDLIFHVDKAGLAGAP
ARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK

--------------------------------------------------------------
>18503_18503_3_COMMD10-AP3S1_COMMD10_chr5_115428397_ENST00000274458_AP3S1_chr5_115230784_ENST00000316788_length(transcript)=1361nt_BP=461nt
GCGGCCGCCATTGGCTGGGTTCGGCGCAGCTAACAGACGGCGGCAGTGCGAGAAAGCCGAAGATGGCGGTCCCCGCGGCGCTGATCCTAC
GGGAGAGCCCCAGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTTCCACGGTTGCTCACTCGGATTCTTCAAA
AACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACC
TAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTC
ATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGG
CTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGGATTTGATTTTCCATGTAGACAAGGTTCACA
ATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACAAATATGAATGAGATTGTTACACAAATTGATGCACAAAATAAGCTGG
AAAAATCTGAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCCCAAGAAATATTA
ACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAAAGGCCACTCCCAGGTAAAATCCAGGGGGAA
GAGTCATCTAAGTTTACCATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTTTTGCTCTTGGATTTAAGTCAAGGTACTGTA
TAGAAGTTGTGTAAAATCAGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTAAAGAAATTGAGTAGTTCCTATGTGATTTTT
TTTTTTCTTTTCTAAACTGCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCTACTACAGTGTTTTAAAAAGTGTTTCAGATA
TTTCTCTAATTATGTACAACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCATTCCTTAATTCCTTCTGCTATATGTCACACA
GTTGTTATTTGGAGAACCAAGTATGTATTGCATGAAAACATTATGACTTTTTTCTCTTAGTTTAAATAAACTCCAAGGTAACTGGACTTC
TAAAGCACCTTTCTGTTTGCCTGATATCTACTTTAGCAATAATTTTTTTTACAACCCTCTGACTCAACAAAGTAAATAAAAGTATATTTT
ATCACTATTAA

>18503_18503_3_COMMD10-AP3S1_COMMD10_chr5_115428397_ENST00000274458_AP3S1_chr5_115230784_ENST00000316788_length(amino acids)=251AA_BP=149
MGSAQLTDGGSARKPKMAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLET
ISFILEQAVYHNVKPAALQQQLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKVFVETLDKCFENVCELDLIFHVDKVHNILAE
MVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK

--------------------------------------------------------------
>18503_18503_4_COMMD10-AP3S1_COMMD10_chr5_115428397_ENST00000274458_AP3S1_chr5_115230784_ENST00000505423_length(transcript)=1072nt_BP=461nt
GCGGCCGCCATTGGCTGGGTTCGGCGCAGCTAACAGACGGCGGCAGTGCGAGAAAGCCGAAGATGGCGGTCCCCGCGGCGCTGATCCTAC
GGGAGAGCCCCAGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTTCCACGGTTGCTCACTCGGATTCTTCAAA
AACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACC
TAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTC
ATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGG
CTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGGATTTGATTTTCCATGTAGACAAGGCTGGCT
TAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCCCAAGAAATATTAACATTGGTGACATCAGTA
TAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAAAGGCCACTCCCAGGTAAAATCCAGGGGGAAGAGTCATCTAAGTTTACC
ATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTTTTGCTCTTGGATTTAAGTCAAGGTACTGTATAGAAGTTGTGTAAAATC
AGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTAAAGAAATTGAGTAGTTCCTATGTGATTTTTTTTTTTCTTTTCTAAACT
GCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCTACTACAGTGTTTTAAAAAGTGTTTCAGATATTTCTCTAATTATGTACA
ACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCATTCCTTAATTCCTTCTGCTATATGTCACACAGTTGTTATTT

>18503_18503_4_COMMD10-AP3S1_COMMD10_chr5_115428397_ENST00000274458_AP3S1_chr5_115230784_ENST00000505423_length(amino acids)=215AA_BP=149
MGSAQLTDGGSARKPKMAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLET
ISFILEQAVYHNVKPAALQQQLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKVFVETLDKCFENVCELDLIFHVDKAGLAGAP
ARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK

--------------------------------------------------------------
>18503_18503_5_COMMD10-AP3S1_COMMD10_chr5_115428397_ENST00000515539_AP3S1_chr5_115230783_ENST00000316788_length(transcript)=1391nt_BP=491nt
GACACTCTGGTGGGAAAGGCTCACGCTGCTGCTGGAGGGTCTTTAATAGCCAACATGTGTTAATACCCCTTTTAAATCAGTATCGAATAG
GGGACCGAATTTTTGGTTGGTAGAAGAATCTAGCCTGGCTTTGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGAT
TTCCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGG
CATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAG
CAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAA
CAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGG
ATTTGATTTTCCATGTAGACAAGGTTCACAATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACAAATATGAATGAGATTG
TTACACAAATTGATGCACAAAATAAGCTGGAAAAATCTGAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATA
TGAATCTTCCTGAGATCCCAAGAAATATTAACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAA
AGGCCACTCCCAGGTAAAATCCAGGGGGAAGAGTCATCTAAGTTTACCATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTT
TTGCTCTTGGATTTAAGTCAAGGTACTGTATAGAAGTTGTGTAAAATCAGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTA
AAGAAATTGAGTAGTTCCTATGTGATTTTTTTTTTTCTTTTCTAAACTGCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCT
ACTACAGTGTTTTAAAAAGTGTTTCAGATATTTCTCTAATTATGTACAACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCAT
TCCTTAATTCCTTCTGCTATATGTCACACAGTTGTTATTTGGAGAACCAAGTATGTATTGCATGAAAACATTATGACTTTTTTCTCTTAG
TTTAAATAAACTCCAAGGTAACTGGACTTCTAAAGCACCTTTCTGTTTGCCTGATATCTACTTTAGCAATAATTTTTTTTACAACCCTCT
GACTCAACAAAGTAAATAAAAGTATATTTTATCACTATTAA

>18503_18503_5_COMMD10-AP3S1_COMMD10_chr5_115428397_ENST00000515539_AP3S1_chr5_115230783_ENST00000316788_length(amino acids)=221AA_BP=119
MKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQD
KAEAFVNTWSSMGQETVEKFRQRILAPCKVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEA
GLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK

--------------------------------------------------------------
>18503_18503_6_COMMD10-AP3S1_COMMD10_chr5_115428397_ENST00000515539_AP3S1_chr5_115230783_ENST00000505423_length(transcript)=1102nt_BP=491nt
GACACTCTGGTGGGAAAGGCTCACGCTGCTGCTGGAGGGTCTTTAATAGCCAACATGTGTTAATACCCCTTTTAAATCAGTATCGAATAG
GGGACCGAATTTTTGGTTGGTAGAAGAATCTAGCCTGGCTTTGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGAT
TTCCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGG
CATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAG
CAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAA
CAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGG
ATTTGATTTTCCATGTAGACAAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCC
CAAGAAATATTAACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAAAGGCCACTCCCAGGTAAA
ATCCAGGGGGAAGAGTCATCTAAGTTTACCATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTTTTGCTCTTGGATTTAAGT
CAAGGTACTGTATAGAAGTTGTGTAAAATCAGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTAAAGAAATTGAGTAGTTCC
TATGTGATTTTTTTTTTTCTTTTCTAAACTGCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCTACTACAGTGTTTTAAAAA
GTGTTTCAGATATTTCTCTAATTATGTACAACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCATTCCTTAATTCCTTCTGCT
ATATGTCACACAGTTGTTATTT

>18503_18503_6_COMMD10-AP3S1_COMMD10_chr5_115428397_ENST00000515539_AP3S1_chr5_115230783_ENST00000505423_length(amino acids)=185AA_BP=119
MKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQD
KAEAFVNTWSSMGQETVEKFRQRILAPCKVFVETLDKCFENVCELDLIFHVDKAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPN
LPSFK

--------------------------------------------------------------
>18503_18503_7_COMMD10-AP3S1_COMMD10_chr5_115428397_ENST00000515539_AP3S1_chr5_115230784_ENST00000316788_length(transcript)=1391nt_BP=491nt
GACACTCTGGTGGGAAAGGCTCACGCTGCTGCTGGAGGGTCTTTAATAGCCAACATGTGTTAATACCCCTTTTAAATCAGTATCGAATAG
GGGACCGAATTTTTGGTTGGTAGAAGAATCTAGCCTGGCTTTGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGAT
TTCCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGG
CATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAG
CAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAA
CAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGG
ATTTGATTTTCCATGTAGACAAGGTTCACAATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACAAATATGAATGAGATTG
TTACACAAATTGATGCACAAAATAAGCTGGAAAAATCTGAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATA
TGAATCTTCCTGAGATCCCAAGAAATATTAACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAA
AGGCCACTCCCAGGTAAAATCCAGGGGGAAGAGTCATCTAAGTTTACCATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTT
TTGCTCTTGGATTTAAGTCAAGGTACTGTATAGAAGTTGTGTAAAATCAGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTA
AAGAAATTGAGTAGTTCCTATGTGATTTTTTTTTTTCTTTTCTAAACTGCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCT
ACTACAGTGTTTTAAAAAGTGTTTCAGATATTTCTCTAATTATGTACAACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCAT
TCCTTAATTCCTTCTGCTATATGTCACACAGTTGTTATTTGGAGAACCAAGTATGTATTGCATGAAAACATTATGACTTTTTTCTCTTAG
TTTAAATAAACTCCAAGGTAACTGGACTTCTAAAGCACCTTTCTGTTTGCCTGATATCTACTTTAGCAATAATTTTTTTTACAACCCTCT
GACTCAACAAAGTAAATAAAAGTATATTTTATCACTATTAA

>18503_18503_7_COMMD10-AP3S1_COMMD10_chr5_115428397_ENST00000515539_AP3S1_chr5_115230784_ENST00000316788_length(amino acids)=221AA_BP=119
MKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQD
KAEAFVNTWSSMGQETVEKFRQRILAPCKVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEA
GLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK

--------------------------------------------------------------
>18503_18503_8_COMMD10-AP3S1_COMMD10_chr5_115428397_ENST00000515539_AP3S1_chr5_115230784_ENST00000505423_length(transcript)=1102nt_BP=491nt
GACACTCTGGTGGGAAAGGCTCACGCTGCTGCTGGAGGGTCTTTAATAGCCAACATGTGTTAATACCCCTTTTAAATCAGTATCGAATAG
GGGACCGAATTTTTGGTTGGTAGAAGAATCTAGCCTGGCTTTGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGAT
TTCCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGG
CATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAG
CAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAA
CAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGG
ATTTGATTTTCCATGTAGACAAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCC
CAAGAAATATTAACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAAAGGCCACTCCCAGGTAAA
ATCCAGGGGGAAGAGTCATCTAAGTTTACCATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTTTTGCTCTTGGATTTAAGT
CAAGGTACTGTATAGAAGTTGTGTAAAATCAGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTAAAGAAATTGAGTAGTTCC
TATGTGATTTTTTTTTTTCTTTTCTAAACTGCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCTACTACAGTGTTTTAAAAA
GTGTTTCAGATATTTCTCTAATTATGTACAACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCATTCCTTAATTCCTTCTGCT
ATATGTCACACAGTTGTTATTT

>18503_18503_8_COMMD10-AP3S1_COMMD10_chr5_115428397_ENST00000515539_AP3S1_chr5_115230784_ENST00000505423_length(amino acids)=185AA_BP=119
MKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQD
KAEAFVNTWSSMGQETVEKFRQRILAPCKVFVETLDKCFENVCELDLIFHVDKAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPN
LPSFK

--------------------------------------------------------------
>18503_18503_9_COMMD10-AP3S1_COMMD10_chr5_115469875_ENST00000274458_AP3S1_chr5_115202367_ENST00000316788_length(transcript)=1676nt_BP=572nt
GCGGCCGCCATTGGCTGGGTTCGGCGCAGCTAACAGACGGCGGCAGTGCGAGAAAGCCGAAGATGGCGGTCCCCGCGGCGCTGATCCTAC
GGGAGAGCCCCAGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTTCCACGGTTGCTCACTCGGATTCTTCAAA
AACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACC
TAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTC
ATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGG
CTCCCTGTAAGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCAAGCTGTGT
TACAACTCGGAGTGAACAATGAAGATTCAAAGAGTGAAGATACACAACAGCAAATCATCAGGGAGACTTTCCATTTGGTATCTAAGAGAG
ATGAAAATGTTTGTAATTTCCTAGAAGGAGGATTATTAATTGGAGGATCTGACAACAAACTGATTTATAGACATTATGCAACGTTATATT
TTGTCTTCTGTGTGGATTCTTCAGAAAGTGAACTTGGCATTTTAGATCTAATTCAAGTATTTGTGGAAACATTAGACAAATGTTTTGAAA
ATGTCTGTGAGCTGGATTTGATTTTCCATGTAGACAAGGTTCACAATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACAA
ATATGAATGAGATTGTTACACAAATTGATGCACAAAATAAGCTGGAAAAATCTGAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTAT
CAGCTGTAAAGAATATGAATCTTCCTGAGATCCCAAGAAATATTAACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCTCTTTTA
AATAAAAATGTAAAAAGGCCACTCCCAGGTAAAATCCAGGGGGAAGAGTCATCTAAGTTTACCATGCAGTTGTTTACCAAAAATAGAGGA
GGAGAGTCTTAACTTTTGCTCTTGGATTTAAGTCAAGGTACTGTATAGAAGTTGTGTAAAATCAGTATGAAAGTTCAATGTTGCTGTTCT
TGCTCAGTGATTTTAAAGAAATTGAGTAGTTCCTATGTGATTTTTTTTTTTCTTTTCTAAACTGCATTCCTGTGCCCACCTACGGCATGC
CTCTATGTATTGGCTACTACAGTGTTTTAAAAAGTGTTTCAGATATTTCTCTAATTATGTACAACCTAAAATGTTGGTGTTTTGTATGGA
TCACAAGTGCAGCATTCCTTAATTCCTTCTGCTATATGTCACACAGTTGTTATTTGGAGAACCAAGTATGTATTGCATGAAAACATTATG
ACTTTTTTCTCTTAGTTTAAATAAACTCCAAGGTAACTGGACTTCTAAAGCACCTTTCTGTTTGCCTGATATCTACTTTAGCAATAATTT
TTTTTACAACCCTCTGACTCAACAAAGTAAATAAAAGTATATTTTATCACTATTAA

>18503_18503_9_COMMD10-AP3S1_COMMD10_chr5_115469875_ENST00000274458_AP3S1_chr5_115202367_ENST00000316788_length(amino acids)=356AA_BP=186
MGSAQLTDGGSARKPKMAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLET
ISFILEQAVYHNVKPAALQQQLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKLETVGWQLNLQMAHSAQAKLKSPQAVLQLGV
NNEDSKSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCEL
DLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK

--------------------------------------------------------------
>18503_18503_10_COMMD10-AP3S1_COMMD10_chr5_115469875_ENST00000274458_AP3S1_chr5_115249059_ENST00000316788_length(transcript)=1292nt_BP=572nt
GCGGCCGCCATTGGCTGGGTTCGGCGCAGCTAACAGACGGCGGCAGTGCGAGAAAGCCGAAGATGGCGGTCCCCGCGGCGCTGATCCTAC
GGGAGAGCCCCAGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTTCCACGGTTGCTCACTCGGATTCTTCAAA
AACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACC
TAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTC
ATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGG
CTCCCTGTAAGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCAAGCTGTGT
TACAACTCGGAGTGAACAATGAAGATTCAAAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTC
CTGAGATCCCAAGAAATATTAACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAAAGGCCACTC
CCAGGTAAAATCCAGGGGGAAGAGTCATCTAAGTTTACCATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTTTTGCTCTTG
GATTTAAGTCAAGGTACTGTATAGAAGTTGTGTAAAATCAGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTAAAGAAATTG
AGTAGTTCCTATGTGATTTTTTTTTTTCTTTTCTAAACTGCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCTACTACAGTG
TTTTAAAAAGTGTTTCAGATATTTCTCTAATTATGTACAACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCATTCCTTAATT
CCTTCTGCTATATGTCACACAGTTGTTATTTGGAGAACCAAGTATGTATTGCATGAAAACATTATGACTTTTTTCTCTTAGTTTAAATAA
ACTCCAAGGTAACTGGACTTCTAAAGCACCTTTCTGTTTGCCTGATATCTACTTTAGCAATAATTTTTTTTACAACCCTCTGACTCAACA
AAGTAAATAAAAGTATATTTTATCACTATTAA

>18503_18503_10_COMMD10-AP3S1_COMMD10_chr5_115469875_ENST00000274458_AP3S1_chr5_115249059_ENST00000316788_length(amino acids)=228AA_BP=186
MGSAQLTDGGSARKPKMAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLET
ISFILEQAVYHNVKPAALQQQLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKLETVGWQLNLQMAHSAQAKLKSPQAVLQLGV
NNEDSKAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK

--------------------------------------------------------------
>18503_18503_11_COMMD10-AP3S1_COMMD10_chr5_115469875_ENST00000515539_AP3S1_chr5_115202367_ENST00000316788_length(transcript)=1706nt_BP=602nt
GACACTCTGGTGGGAAAGGCTCACGCTGCTGCTGGAGGGTCTTTAATAGCCAACATGTGTTAATACCCCTTTTAAATCAGTATCGAATAG
GGGACCGAATTTTTGGTTGGTAGAAGAATCTAGCCTGGCTTTGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGAT
TTCCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGG
CATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAG
CAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAA
CAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTC
AAGCAAAACTAAAATCTCCTCAAGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGTGAAGATACACAACAGCAAATCATCA
GGGAGACTTTCCATTTGGTATCTAAGAGAGATGAAAATGTTTGTAATTTCCTAGAAGGAGGATTATTAATTGGAGGATCTGACAACAAAC
TGATTTATAGACATTATGCAACGTTATATTTTGTCTTCTGTGTGGATTCTTCAGAAAGTGAACTTGGCATTTTAGATCTAATTCAAGTAT
TTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGGATTTGATTTTCCATGTAGACAAGGTTCACAATATTCTTGCAGAAA
TGGTGATGGGGGGAATGGTATTGGAGACAAATATGAATGAGATTGTTACACAAATTGATGCACAAAATAAGCTGGAAAAATCTGAGGCTG
GCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCCCAAGAAATATTAACATTGGTGACATCA
GTATAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAAAGGCCACTCCCAGGTAAAATCCAGGGGGAAGAGTCATCTAAGTTT
ACCATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTTTTGCTCTTGGATTTAAGTCAAGGTACTGTATAGAAGTTGTGTAAA
ATCAGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTAAAGAAATTGAGTAGTTCCTATGTGATTTTTTTTTTTCTTTTCTAA
ACTGCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCTACTACAGTGTTTTAAAAAGTGTTTCAGATATTTCTCTAATTATGT
ACAACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCATTCCTTAATTCCTTCTGCTATATGTCACACAGTTGTTATTTGGAGA
ACCAAGTATGTATTGCATGAAAACATTATGACTTTTTTCTCTTAGTTTAAATAAACTCCAAGGTAACTGGACTTCTAAAGCACCTTTCTG
TTTGCCTGATATCTACTTTAGCAATAATTTTTTTTACAACCCTCTGACTCAACAAAGTAAATAAAAGTATATTTTATCACTATTAA

>18503_18503_11_COMMD10-AP3S1_COMMD10_chr5_115469875_ENST00000515539_AP3S1_chr5_115202367_ENST00000316788_length(amino acids)=326AA_BP=156
MKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQD
KAEAFVNTWSSMGQETVEKFRQRILAPCKLETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSKSEDTQQQIIRETFHLVSKRDENVC
NFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEI
VTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK

--------------------------------------------------------------
>18503_18503_12_COMMD10-AP3S1_COMMD10_chr5_115469875_ENST00000515539_AP3S1_chr5_115249059_ENST00000316788_length(transcript)=1322nt_BP=602nt
GACACTCTGGTGGGAAAGGCTCACGCTGCTGCTGGAGGGTCTTTAATAGCCAACATGTGTTAATACCCCTTTTAAATCAGTATCGAATAG
GGGACCGAATTTTTGGTTGGTAGAAGAATCTAGCCTGGCTTTGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGAT
TTCCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGG
CATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAG
CAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAA
CAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTC
AAGCAAAACTAAAATCTCCTCAAGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGGCTGGCTTAGCAGGAGCTCCAGCCCGTG
CTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCCCAAGAAATATTAACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCT
CTTTTAAATAAAAATGTAAAAAGGCCACTCCCAGGTAAAATCCAGGGGGAAGAGTCATCTAAGTTTACCATGCAGTTGTTTACCAAAAAT
AGAGGAGGAGAGTCTTAACTTTTGCTCTTGGATTTAAGTCAAGGTACTGTATAGAAGTTGTGTAAAATCAGTATGAAAGTTCAATGTTGC
TGTTCTTGCTCAGTGATTTTAAAGAAATTGAGTAGTTCCTATGTGATTTTTTTTTTTCTTTTCTAAACTGCATTCCTGTGCCCACCTACG
GCATGCCTCTATGTATTGGCTACTACAGTGTTTTAAAAAGTGTTTCAGATATTTCTCTAATTATGTACAACCTAAAATGTTGGTGTTTTG
TATGGATCACAAGTGCAGCATTCCTTAATTCCTTCTGCTATATGTCACACAGTTGTTATTTGGAGAACCAAGTATGTATTGCATGAAAAC
ATTATGACTTTTTTCTCTTAGTTTAAATAAACTCCAAGGTAACTGGACTTCTAAAGCACCTTTCTGTTTGCCTGATATCTACTTTAGCAA
TAATTTTTTTTACAACCCTCTGACTCAACAAAGTAAATAAAAGTATATTTTATCACTATTAA

>18503_18503_12_COMMD10-AP3S1_COMMD10_chr5_115469875_ENST00000515539_AP3S1_chr5_115249059_ENST00000316788_length(amino acids)=198AA_BP=156
MKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQD
KAEAFVNTWSSMGQETVEKFRQRILAPCKLETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSKAGLAGAPARAVSAVKNMNLPEIPR
NINIGDISIKVPNLPSFK

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Fusion Gene PPI Analysis for COMMD10-AP3S1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for COMMD10-AP3S1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for COMMD10-AP3S1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human