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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANAPC5-LTA4H (FusionGDB2 ID:HG51433TG4048)

Fusion Gene Summary for ANAPC5-LTA4H

check button Fusion gene summary
Fusion gene informationFusion gene name: ANAPC5-LTA4H
Fusion gene ID: hg51433tg4048
HgeneTgene
Gene symbol

ANAPC5

LTA4H

Gene ID

51433

4048

Gene nameanaphase promoting complex subunit 5leukotriene A4 hydrolase
SynonymsAPC5-
Cytomap('ANAPC5')('LTA4H')

12q24.31

12q23.1

Type of geneprotein-codingprotein-coding
Descriptionanaphase-promoting complex subunit 5cyclosome subunit 5leukotriene A-4 hydrolaseLTA-4 hydrolasetesticular secretory protein Li 27
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000261819, ENST00000344395, 
ENST00000441917, ENST00000535482, 
ENST00000541887, ENST00000544314, 
ENST00000536366, 
Fusion gene scores* DoF score9 X 11 X 6=5949 X 9 X 6=486
# samples 118
** MAII scorelog2(11/594*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/486*10)=-2.60288440871842
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANAPC5 [Title/Abstract] AND LTA4H [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANAPC5(121756080)-LTA4H(96402926), # samples:1
Anticipated loss of major functional domain due to fusion event.ANAPC5-LTA4H seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANAPC5-LTA4H seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANAPC5-LTA4H seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANAPC5-LTA4H seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANAPC5-LTA4H seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ANAPC5-LTA4H seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ANAPC5-LTA4H seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANAPC5

GO:0070979

protein K11-linked ubiquitination

18485873

TgeneLTA4H

GO:0019370

leukotriene biosynthetic process

9774412|15078870

TgeneLTA4H

GO:0043171

peptide catabolic process

9774412|15078870|18804029


check buttonFusion gene breakpoints across ANAPC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LTA4H (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3LS-01AANAPC5chr12

121756080

-LTA4Hchr12

96402926

-


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Fusion Gene ORF analysis for ANAPC5-LTA4H

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000261819ENST00000548375ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
5CDS-5UTRENST00000344395ENST00000548375ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
5CDS-5UTRENST00000441917ENST00000548375ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
5CDS-5UTRENST00000535482ENST00000548375ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
5CDS-5UTRENST00000541887ENST00000548375ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
5UTR-3CDSENST00000544314ENST00000228740ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
5UTR-3CDSENST00000544314ENST00000413268ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
5UTR-3CDSENST00000544314ENST00000552789ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
5UTR-5UTRENST00000544314ENST00000548375ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
Frame-shiftENST00000261819ENST00000228740ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
Frame-shiftENST00000261819ENST00000413268ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
Frame-shiftENST00000261819ENST00000552789ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
Frame-shiftENST00000344395ENST00000228740ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
Frame-shiftENST00000344395ENST00000413268ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
Frame-shiftENST00000344395ENST00000552789ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
Frame-shiftENST00000535482ENST00000228740ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
Frame-shiftENST00000535482ENST00000413268ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
Frame-shiftENST00000535482ENST00000552789ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
Frame-shiftENST00000541887ENST00000228740ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
Frame-shiftENST00000541887ENST00000413268ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
Frame-shiftENST00000541887ENST00000552789ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
In-frameENST00000441917ENST00000228740ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
In-frameENST00000441917ENST00000413268ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
In-frameENST00000441917ENST00000552789ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
intron-3CDSENST00000536366ENST00000228740ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
intron-3CDSENST00000536366ENST00000413268ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
intron-3CDSENST00000536366ENST00000552789ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-
intron-5UTRENST00000536366ENST00000548375ANAPC5chr12

121756080

-LTA4Hchr12

96402926

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000441917ANAPC5chr12121756080-ENST00000228740LTA4Hchr1296402926-22671649171654545
ENST00000441917ANAPC5chr12121756080-ENST00000552789LTA4Hchr1296402926-22651649171654545
ENST00000441917ANAPC5chr12121756080-ENST00000413268LTA4Hchr1296402926-21051649171654545

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000441917ENST00000228740ANAPC5chr12121756080-LTA4Hchr1296402926-0.0025187490.9974813
ENST00000441917ENST00000552789ANAPC5chr12121756080-LTA4Hchr1296402926-0.0025306630.9974693
ENST00000441917ENST00000413268ANAPC5chr12121756080-LTA4Hchr1296402926-0.0035545120.9964455

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Fusion Genomic Features for ANAPC5-LTA4H


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ANAPC5-LTA4H


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:121756080/chr12:96402926)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANAPC5chr12:121756080chr12:96402926ENST00000261819-1517209_249631756.0RepeatNote=TPR 1
HgeneANAPC5chr12:121756080chr12:96402926ENST00000261819-1517250_300631756.0RepeatNote=TPR 2
HgeneANAPC5chr12:121756080chr12:96402926ENST00000261819-1517301_337631756.0RepeatNote=TPR 3
HgeneANAPC5chr12:121756080chr12:96402926ENST00000261819-1517338_378631756.0RepeatNote=TPR 4
HgeneANAPC5chr12:121756080chr12:96402926ENST00000261819-1517379_418631756.0RepeatNote=TPR 5
HgeneANAPC5chr12:121756080chr12:96402926ENST00000261819-1517419_466631756.0RepeatNote=TPR 6
HgeneANAPC5chr12:121756080chr12:96402926ENST00000261819-1517467_500631756.0RepeatNote=TPR 7
HgeneANAPC5chr12:121756080chr12:96402926ENST00000261819-1517501_540631756.0RepeatNote=TPR 8
HgeneANAPC5chr12:121756080chr12:96402926ENST00000261819-1517541_580631756.0RepeatNote=TPR 9
HgeneANAPC5chr12:121756080chr12:96402926ENST00000261819-1517581_620631756.0RepeatNote=TPR 10
HgeneANAPC5chr12:121756080chr12:96402926ENST00000344395-1315209_249519644.0RepeatNote=TPR 1
HgeneANAPC5chr12:121756080chr12:96402926ENST00000344395-1315250_300519644.0RepeatNote=TPR 2
HgeneANAPC5chr12:121756080chr12:96402926ENST00000344395-1315301_337519644.0RepeatNote=TPR 3
HgeneANAPC5chr12:121756080chr12:96402926ENST00000344395-1315338_378519644.0RepeatNote=TPR 4
HgeneANAPC5chr12:121756080chr12:96402926ENST00000344395-1315379_418519644.0RepeatNote=TPR 5
HgeneANAPC5chr12:121756080chr12:96402926ENST00000344395-1315419_466519644.0RepeatNote=TPR 6
HgeneANAPC5chr12:121756080chr12:96402926ENST00000344395-1315467_500519644.0RepeatNote=TPR 7
HgeneANAPC5chr12:121756080chr12:96402926ENST00000441917-1416209_249519644.0RepeatNote=TPR 1
HgeneANAPC5chr12:121756080chr12:96402926ENST00000441917-1416250_300519644.0RepeatNote=TPR 2
HgeneANAPC5chr12:121756080chr12:96402926ENST00000441917-1416301_337519644.0RepeatNote=TPR 3
HgeneANAPC5chr12:121756080chr12:96402926ENST00000441917-1416338_378519644.0RepeatNote=TPR 4
HgeneANAPC5chr12:121756080chr12:96402926ENST00000441917-1416379_418519644.0RepeatNote=TPR 5
HgeneANAPC5chr12:121756080chr12:96402926ENST00000441917-1416419_466519644.0RepeatNote=TPR 6
HgeneANAPC5chr12:121756080chr12:96402926ENST00000441917-1416467_500519644.0RepeatNote=TPR 7
TgeneLTA4Hchr12:121756080chr12:96402926ENST000002287401319564_566459612.0RegionSubstrate binding
TgeneLTA4Hchr12:121756080chr12:96402926ENST000004132681318564_566435489.6666666666667RegionSubstrate binding
TgeneLTA4Hchr12:121756080chr12:96402926ENST000005527891319564_566435588.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANAPC5chr12:121756080chr12:96402926ENST00000261819-1517621_660631756.0RepeatNote=TPR 11
HgeneANAPC5chr12:121756080chr12:96402926ENST00000261819-1517661_696631756.0RepeatNote=TPR 12
HgeneANAPC5chr12:121756080chr12:96402926ENST00000261819-1517697_736631756.0RepeatNote=TPR 13
HgeneANAPC5chr12:121756080chr12:96402926ENST00000344395-1315501_540519644.0RepeatNote=TPR 8
HgeneANAPC5chr12:121756080chr12:96402926ENST00000344395-1315541_580519644.0RepeatNote=TPR 9
HgeneANAPC5chr12:121756080chr12:96402926ENST00000344395-1315581_620519644.0RepeatNote=TPR 10
HgeneANAPC5chr12:121756080chr12:96402926ENST00000344395-1315621_660519644.0RepeatNote=TPR 11
HgeneANAPC5chr12:121756080chr12:96402926ENST00000344395-1315661_696519644.0RepeatNote=TPR 12
HgeneANAPC5chr12:121756080chr12:96402926ENST00000344395-1315697_736519644.0RepeatNote=TPR 13
HgeneANAPC5chr12:121756080chr12:96402926ENST00000441917-1416501_540519644.0RepeatNote=TPR 8
HgeneANAPC5chr12:121756080chr12:96402926ENST00000441917-1416541_580519644.0RepeatNote=TPR 9
HgeneANAPC5chr12:121756080chr12:96402926ENST00000441917-1416581_620519644.0RepeatNote=TPR 10
HgeneANAPC5chr12:121756080chr12:96402926ENST00000441917-1416621_660519644.0RepeatNote=TPR 11
HgeneANAPC5chr12:121756080chr12:96402926ENST00000441917-1416661_696519644.0RepeatNote=TPR 12
HgeneANAPC5chr12:121756080chr12:96402926ENST00000441917-1416697_736519644.0RepeatNote=TPR 13
HgeneANAPC5chr12:121756080chr12:96402926ENST00000536366-15209_2490220.0RepeatNote=TPR 1
HgeneANAPC5chr12:121756080chr12:96402926ENST00000536366-15250_3000220.0RepeatNote=TPR 2
HgeneANAPC5chr12:121756080chr12:96402926ENST00000536366-15301_3370220.0RepeatNote=TPR 3
HgeneANAPC5chr12:121756080chr12:96402926ENST00000536366-15338_3780220.0RepeatNote=TPR 4
HgeneANAPC5chr12:121756080chr12:96402926ENST00000536366-15379_4180220.0RepeatNote=TPR 5
HgeneANAPC5chr12:121756080chr12:96402926ENST00000536366-15419_4660220.0RepeatNote=TPR 6
HgeneANAPC5chr12:121756080chr12:96402926ENST00000536366-15467_5000220.0RepeatNote=TPR 7
HgeneANAPC5chr12:121756080chr12:96402926ENST00000536366-15501_5400220.0RepeatNote=TPR 8
HgeneANAPC5chr12:121756080chr12:96402926ENST00000536366-15541_5800220.0RepeatNote=TPR 9
HgeneANAPC5chr12:121756080chr12:96402926ENST00000536366-15581_6200220.0RepeatNote=TPR 10
HgeneANAPC5chr12:121756080chr12:96402926ENST00000536366-15621_6600220.0RepeatNote=TPR 11
HgeneANAPC5chr12:121756080chr12:96402926ENST00000536366-15661_6960220.0RepeatNote=TPR 12
HgeneANAPC5chr12:121756080chr12:96402926ENST00000536366-15697_7360220.0RepeatNote=TPR 13
TgeneLTA4Hchr12:121756080chr12:96402926ENST000002287401319135_137459612.0RegionSubstrate binding
TgeneLTA4Hchr12:121756080chr12:96402926ENST000002287401319267_272459612.0RegionSubstrate binding
TgeneLTA4Hchr12:121756080chr12:96402926ENST000002287401319362_365459612.0RegionInhibitor ARM1 binding
TgeneLTA4Hchr12:121756080chr12:96402926ENST000004132681318135_137435489.6666666666667RegionSubstrate binding
TgeneLTA4Hchr12:121756080chr12:96402926ENST000004132681318267_272435489.6666666666667RegionSubstrate binding
TgeneLTA4Hchr12:121756080chr12:96402926ENST000004132681318362_365435489.6666666666667RegionInhibitor ARM1 binding
TgeneLTA4Hchr12:121756080chr12:96402926ENST000005527891319135_137435588.0RegionSubstrate binding
TgeneLTA4Hchr12:121756080chr12:96402926ENST000005527891319267_272435588.0RegionSubstrate binding
TgeneLTA4Hchr12:121756080chr12:96402926ENST000005527891319362_365435588.0RegionInhibitor ARM1 binding


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Fusion Gene Sequence for ANAPC5-LTA4H


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4300_4300_1_ANAPC5-LTA4H_ANAPC5_chr12_121756080_ENST00000441917_LTA4H_chr12_96402926_ENST00000228740_length(transcript)=2267nt_BP=1649nt
AGGGCCCAGATATTACACTGTCAAAACTTTACAAGTTAATTGAAGAGTCTTGTCCACAGCTGGCAAATTCAGTGCAGATCAGAATCAAAC
TGATGGCTGAAGGCGAGTTGAAGGATATGGAACAGTTTTTTGATGACCTTTCAGATTCTTTCTCTGGAACTGAACCAGAGGTTCACAAAA
CAAGTGTAGTAGGTTTGTTTCTGCGTCACATGATCTTGGCCTACAGTAAGCTTTCTTTCAGCCAAGTGTTTAAACTGTACACTGCCCTTC
AGCAGTACTTCCAGAATGGTGAGAAAAAGACAGTGGAGGATGCTGATATGGAACTGACCAGTAGAGATGAGGGTGAAAGAAAAATGGAAA
AAGAAGAACTTGATGTATCTGTAAGAGAAGAGGAGGTATCTTGCAGTGGGCCTCTGTCCCAAAAACAAGCAGAATTTTTTCTTTCTCAAC
AGGCTTCTTTGCTAAAGAATGATGAGACTAAGGCCCTCACTCCAGCTTCCTTGCAGAAGGAATTAAACAATTTGTTGAAATTTAATCCTG
ATTTTGCTGAAGCGCATTATCTCAGCTACTTAAACAACCTCCGTGTCCAAGATGTTTTCAGTTCAACACACAGTCTCCTCCATTATTTTG
ATCGTCTGATTCTTACCGGAGCCGAAAGCAAAAGTAATGGGGAAGAGGGCTATGGCCGGAGCTTGAGATACGCCGCTCTGAATCTTGCCG
CCCTGCACTGCCGCTTCGGTCACTATCAACAGGCAGAGCTCGCCCTGCAGGAGGCAATTAGGATTGCCCAGGAGTCCAACGATCACGTGT
GTCTCCAGCACTGTTTGAGCTGGCTTTATGTGCTGGGGCAGAAGAGATCCGATAGCTATGTTCTGCTGGAGCATTCTGTGAAGAAGGCAG
TACATTTTGGGTTACCGAGAGCTTTTGCTGGGAAGACGGCAAACAAGCTGATGGATGCCCTAAAGGACTCCGACCTCCTGCACTGGAAAC
ACAGCCTGTCAGAGCTCATCGATATCAGCATCGCACAGAAAACGGCCATCTGGAGGCTGTATGGCCGCAGCACCATGGCACTGCAACAGG
CCCAGATGTTGCTGAGCATGAACAGCCTGGAGGCGGTGAATGCGGGCGTGCAGCAGAACAACACAGAGTCCTTTGCTGTCGCACTCTGCC
ACCTCGCAGAGCTACACGCGGAGCAGGGCTGTTTTGCTGCAGCTTCTGAAGTGTTAAAGCACTTGAAGGAACGATTTCCGCCTAATAGTC
AGCACGCCCAGTTATGGATGCTATGTGATCAAAAAATACAGTTTGACAGAGCAATGAATGATGGCAAATATCATTTGGCTGATTCACTTG
TTACAGGAATCACAGCTCTCAATAGCATAGAGGGTGTTTATAGGAAAGCGGTTGTATTACAAGCTCAGAACCAAATGTCAGAGGCACATA
AGCTTTTACAAAAATTGTTGGTTCATTGTCAGAAACTGAAGAACACAGAAATGGTGATCAGTGTCCTACTGTCCGTGGCAGAGCTGTACT
GGCGATCTTCCTCCCCTACCATCGCGCTGCCCATGCTCCTGCAGGCTCTGGCCCTCTCCAAGGAGTACCGGTTACAGTACTTGGCCTCTG
AAACAGTGCTGAACTTGGCTTTTGCGCAGTTATGATATGACTCTGACAAATGCTTGTATTGCCTTAAGTCAAAGATGGATTACTGCCAAA
GAAGATGATTTAAATTCATTCAATGCCACAGACCTGAAGGATCTCTCTTCTCATCAATTGAATGAGTTTTTAGCACAGACGCTCCAGAGG
GCACCTCTTCCATTGGGGCACATAAAGCGAATGCAAGAGGTGTACAACTTCAATGCCATTAACAATTCTGAAATACGATTCAGATGGCTG
CGGCTCTGCATTCAATCCAAGTGGGAGGACGCAATTCCTTTGGCGCTAAAGATGGCAACTGAACAAGGAAGAATGAAGTTTACCCGGCCC
TTATTCAAGGATCTTGCTGCCTTTGACAAATCCCATGATCAAGCTGTCCGAACCTACCAAGAGCACAAAGCAAGCATGCATCCCGTGACT
GCAATGCTGGTGGGGAAAGACTTAAAAGTGGATTAAAGACCTGCGTATTGATGATTTTAGAGATTTCTCTTTTTTAAATGGAATTCGTAA
AGAAATATAAAACTTCAGCTCACAATTAAAACTGTCTTTTTAGTTTTGGCTTTTTATTGTTTTGTTGGTGATTTTACTGAAATAAAGTTG

>4300_4300_1_ANAPC5-LTA4H_ANAPC5_chr12_121756080_ENST00000441917_LTA4H_chr12_96402926_ENST00000228740_length(amino acids)=545AA_BP=
MSKLYKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQN
GEKKTVEDADMELTSRDEGERKMEKEELDVSVREEEVSCSGPLSQKQAEFFLSQQASLLKNDETKALTPASLQKELNNLLKFNPDFAEAH
YLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSLRYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCL
SWLYVLGQKRSDSYVLLEHSVKKAVHFGLPRAFAGKTANKLMDALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLS
MNSLEAVNAGVQQNNTESFAVALCHLAELHAEQGCFAAASEVLKHLKERFPPNSQHAQLWMLCDQKIQFDRAMNDGKYHLADSLVTGITA
LNSIEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKEYRLQYLASETVLNL

--------------------------------------------------------------
>4300_4300_2_ANAPC5-LTA4H_ANAPC5_chr12_121756080_ENST00000441917_LTA4H_chr12_96402926_ENST00000413268_length(transcript)=2105nt_BP=1649nt
AGGGCCCAGATATTACACTGTCAAAACTTTACAAGTTAATTGAAGAGTCTTGTCCACAGCTGGCAAATTCAGTGCAGATCAGAATCAAAC
TGATGGCTGAAGGCGAGTTGAAGGATATGGAACAGTTTTTTGATGACCTTTCAGATTCTTTCTCTGGAACTGAACCAGAGGTTCACAAAA
CAAGTGTAGTAGGTTTGTTTCTGCGTCACATGATCTTGGCCTACAGTAAGCTTTCTTTCAGCCAAGTGTTTAAACTGTACACTGCCCTTC
AGCAGTACTTCCAGAATGGTGAGAAAAAGACAGTGGAGGATGCTGATATGGAACTGACCAGTAGAGATGAGGGTGAAAGAAAAATGGAAA
AAGAAGAACTTGATGTATCTGTAAGAGAAGAGGAGGTATCTTGCAGTGGGCCTCTGTCCCAAAAACAAGCAGAATTTTTTCTTTCTCAAC
AGGCTTCTTTGCTAAAGAATGATGAGACTAAGGCCCTCACTCCAGCTTCCTTGCAGAAGGAATTAAACAATTTGTTGAAATTTAATCCTG
ATTTTGCTGAAGCGCATTATCTCAGCTACTTAAACAACCTCCGTGTCCAAGATGTTTTCAGTTCAACACACAGTCTCCTCCATTATTTTG
ATCGTCTGATTCTTACCGGAGCCGAAAGCAAAAGTAATGGGGAAGAGGGCTATGGCCGGAGCTTGAGATACGCCGCTCTGAATCTTGCCG
CCCTGCACTGCCGCTTCGGTCACTATCAACAGGCAGAGCTCGCCCTGCAGGAGGCAATTAGGATTGCCCAGGAGTCCAACGATCACGTGT
GTCTCCAGCACTGTTTGAGCTGGCTTTATGTGCTGGGGCAGAAGAGATCCGATAGCTATGTTCTGCTGGAGCATTCTGTGAAGAAGGCAG
TACATTTTGGGTTACCGAGAGCTTTTGCTGGGAAGACGGCAAACAAGCTGATGGATGCCCTAAAGGACTCCGACCTCCTGCACTGGAAAC
ACAGCCTGTCAGAGCTCATCGATATCAGCATCGCACAGAAAACGGCCATCTGGAGGCTGTATGGCCGCAGCACCATGGCACTGCAACAGG
CCCAGATGTTGCTGAGCATGAACAGCCTGGAGGCGGTGAATGCGGGCGTGCAGCAGAACAACACAGAGTCCTTTGCTGTCGCACTCTGCC
ACCTCGCAGAGCTACACGCGGAGCAGGGCTGTTTTGCTGCAGCTTCTGAAGTGTTAAAGCACTTGAAGGAACGATTTCCGCCTAATAGTC
AGCACGCCCAGTTATGGATGCTATGTGATCAAAAAATACAGTTTGACAGAGCAATGAATGATGGCAAATATCATTTGGCTGATTCACTTG
TTACAGGAATCACAGCTCTCAATAGCATAGAGGGTGTTTATAGGAAAGCGGTTGTATTACAAGCTCAGAACCAAATGTCAGAGGCACATA
AGCTTTTACAAAAATTGTTGGTTCATTGTCAGAAACTGAAGAACACAGAAATGGTGATCAGTGTCCTACTGTCCGTGGCAGAGCTGTACT
GGCGATCTTCCTCCCCTACCATCGCGCTGCCCATGCTCCTGCAGGCTCTGGCCCTCTCCAAGGAGTACCGGTTACAGTACTTGGCCTCTG
AAACAGTGCTGAACTTGGCTTTTGCGCAGTTATGATATGACTCTGACAAATGCTTGTATTGCCTTAAGTCAAAGATGGATTACTGCCAAA
GAAGATGATTTAAATTCATTCAATGCCACAGACCTGAAGGATCTCTCTTCTCATCAATTGAATGAGTTTTTAGCACAGACGCTCCAGAGG
ATGGCTGCGGCTCTGCATTCAATCCAAGTGGGAGGACGCAATTCCTTTGGCGCTAAAGATGGCAACTGAACAAGGAAGAATGAAGTTTAC
CCGGCCCTTATTCAAGGATCTTGCTGCCTTTGACAAATCCCATGATCAAGCTGTCCGAACCTACCAAGAGCACAAAGCAAGCATGCATCC
CGTGACTGCAATGCTGGTGGGGAAAGACTTAAAAGTGGATTAAAGACCTGCGTATTGATGATTTTAGAGATTTCTCTTTTTTAAATGGAA

>4300_4300_2_ANAPC5-LTA4H_ANAPC5_chr12_121756080_ENST00000441917_LTA4H_chr12_96402926_ENST00000413268_length(amino acids)=545AA_BP=
MSKLYKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQN
GEKKTVEDADMELTSRDEGERKMEKEELDVSVREEEVSCSGPLSQKQAEFFLSQQASLLKNDETKALTPASLQKELNNLLKFNPDFAEAH
YLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSLRYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCL
SWLYVLGQKRSDSYVLLEHSVKKAVHFGLPRAFAGKTANKLMDALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLS
MNSLEAVNAGVQQNNTESFAVALCHLAELHAEQGCFAAASEVLKHLKERFPPNSQHAQLWMLCDQKIQFDRAMNDGKYHLADSLVTGITA
LNSIEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKEYRLQYLASETVLNL

--------------------------------------------------------------
>4300_4300_3_ANAPC5-LTA4H_ANAPC5_chr12_121756080_ENST00000441917_LTA4H_chr12_96402926_ENST00000552789_length(transcript)=2265nt_BP=1649nt
AGGGCCCAGATATTACACTGTCAAAACTTTACAAGTTAATTGAAGAGTCTTGTCCACAGCTGGCAAATTCAGTGCAGATCAGAATCAAAC
TGATGGCTGAAGGCGAGTTGAAGGATATGGAACAGTTTTTTGATGACCTTTCAGATTCTTTCTCTGGAACTGAACCAGAGGTTCACAAAA
CAAGTGTAGTAGGTTTGTTTCTGCGTCACATGATCTTGGCCTACAGTAAGCTTTCTTTCAGCCAAGTGTTTAAACTGTACACTGCCCTTC
AGCAGTACTTCCAGAATGGTGAGAAAAAGACAGTGGAGGATGCTGATATGGAACTGACCAGTAGAGATGAGGGTGAAAGAAAAATGGAAA
AAGAAGAACTTGATGTATCTGTAAGAGAAGAGGAGGTATCTTGCAGTGGGCCTCTGTCCCAAAAACAAGCAGAATTTTTTCTTTCTCAAC
AGGCTTCTTTGCTAAAGAATGATGAGACTAAGGCCCTCACTCCAGCTTCCTTGCAGAAGGAATTAAACAATTTGTTGAAATTTAATCCTG
ATTTTGCTGAAGCGCATTATCTCAGCTACTTAAACAACCTCCGTGTCCAAGATGTTTTCAGTTCAACACACAGTCTCCTCCATTATTTTG
ATCGTCTGATTCTTACCGGAGCCGAAAGCAAAAGTAATGGGGAAGAGGGCTATGGCCGGAGCTTGAGATACGCCGCTCTGAATCTTGCCG
CCCTGCACTGCCGCTTCGGTCACTATCAACAGGCAGAGCTCGCCCTGCAGGAGGCAATTAGGATTGCCCAGGAGTCCAACGATCACGTGT
GTCTCCAGCACTGTTTGAGCTGGCTTTATGTGCTGGGGCAGAAGAGATCCGATAGCTATGTTCTGCTGGAGCATTCTGTGAAGAAGGCAG
TACATTTTGGGTTACCGAGAGCTTTTGCTGGGAAGACGGCAAACAAGCTGATGGATGCCCTAAAGGACTCCGACCTCCTGCACTGGAAAC
ACAGCCTGTCAGAGCTCATCGATATCAGCATCGCACAGAAAACGGCCATCTGGAGGCTGTATGGCCGCAGCACCATGGCACTGCAACAGG
CCCAGATGTTGCTGAGCATGAACAGCCTGGAGGCGGTGAATGCGGGCGTGCAGCAGAACAACACAGAGTCCTTTGCTGTCGCACTCTGCC
ACCTCGCAGAGCTACACGCGGAGCAGGGCTGTTTTGCTGCAGCTTCTGAAGTGTTAAAGCACTTGAAGGAACGATTTCCGCCTAATAGTC
AGCACGCCCAGTTATGGATGCTATGTGATCAAAAAATACAGTTTGACAGAGCAATGAATGATGGCAAATATCATTTGGCTGATTCACTTG
TTACAGGAATCACAGCTCTCAATAGCATAGAGGGTGTTTATAGGAAAGCGGTTGTATTACAAGCTCAGAACCAAATGTCAGAGGCACATA
AGCTTTTACAAAAATTGTTGGTTCATTGTCAGAAACTGAAGAACACAGAAATGGTGATCAGTGTCCTACTGTCCGTGGCAGAGCTGTACT
GGCGATCTTCCTCCCCTACCATCGCGCTGCCCATGCTCCTGCAGGCTCTGGCCCTCTCCAAGGAGTACCGGTTACAGTACTTGGCCTCTG
AAACAGTGCTGAACTTGGCTTTTGCGCAGTTATGATATGACTCTGACAAATGCTTGTATTGCCTTAAGTCAAAGATGGATTACTGCCAAA
GAAGATGATTTAAATTCATTCAATGCCACAGACCTGAAGGATCTCTCTTCTCATCAATTGAATGAGTTTTTAGCACAGACGCTCCAGAGG
GCACCTCTTCCATTGGGGCACATAAAGCGAATGCAAGAGGTGTACAACTTCAATGCCATTAACAATTCTGAAATACGATTCAGATGGCTG
CGGCTCTGCATTCAATCCAAGTGGGAGGACGCAATTCCTTTGGCGCTAAAGATGGCAACTGAACAAGGAAGAATGAAGTTTACCCGGCCC
TTATTCAAGGATCTTGCTGCCTTTGACAAATCCCATGATCAAGCTGTCCGAACCTACCAAGAGCACAAAGCAAGCATGCATCCCGTGACT
GCAATGCTGGTGGGGAAAGACTTAAAAGTGGATTAAAGACCTGCGTATTGATGATTTTAGAGATTTCTCTTTTTTAAATGGAATTCGTAA
AGAAATATAAAACTTCAGCTCACAATTAAAACTGTCTTTTTAGTTTTGGCTTTTTATTGTTTTGTTGGTGATTTTACTGAAATAAAGTTG

>4300_4300_3_ANAPC5-LTA4H_ANAPC5_chr12_121756080_ENST00000441917_LTA4H_chr12_96402926_ENST00000552789_length(amino acids)=545AA_BP=
MSKLYKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQN
GEKKTVEDADMELTSRDEGERKMEKEELDVSVREEEVSCSGPLSQKQAEFFLSQQASLLKNDETKALTPASLQKELNNLLKFNPDFAEAH
YLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSLRYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCL
SWLYVLGQKRSDSYVLLEHSVKKAVHFGLPRAFAGKTANKLMDALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLS
MNSLEAVNAGVQQNNTESFAVALCHLAELHAEQGCFAAASEVLKHLKERFPPNSQHAQLWMLCDQKIQFDRAMNDGKYHLADSLVTGITA
LNSIEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKEYRLQYLASETVLNL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANAPC5-LTA4H


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANAPC5-LTA4H


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANAPC5-LTA4H


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0004153Atherosclerosis1CTD_human
TgeneC0011570Mental Depression1PSYGENET
TgeneC0011581Depressive disorder1PSYGENET
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC1563937Atherogenesis1CTD_human