Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CHMP3-REEP1 (FusionGDB2 ID:HG51652TG65055)

Fusion Gene Summary for CHMP3-REEP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CHMP3-REEP1
Fusion gene ID: hg51652tg65055
HgeneTgene
Gene symbol

CHMP3

REEP1

Gene ID

51652

65055

Gene namecharged multivesicular body protein 3receptor accessory protein 1
SynonymsCGI-149|NEDF|VPS24C2orf23|HMN5B|SPG31|Yip2a
Cytomap('CHMP3')('REEP1')

2p11.2

2p11.2

Type of geneprotein-codingprotein-coding
Descriptioncharged multivesicular body protein 325.1 proteinCHMP family, member 3chromatin-modifying protein 3neuroendocrine differentiation factorvacuolar protein sorting 24 homologvacuolar protein sorting-associated protein 24receptor expression-enhancing protein 1spastic paraplegia 31 protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263856, ENST00000409727, 
ENST00000409225, ENST00000439940, 
ENST00000494623, 
Fusion gene scores* DoF score10 X 6 X 6=3609 X 5 X 8=360
# samples 119
** MAII scorelog2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHMP3 [Title/Abstract] AND REEP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHMP3(86790427)-REEP1(86459925), # samples:1
Anticipated loss of major functional domain due to fusion event.CHMP3-REEP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHMP3-REEP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHMP3-REEP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CHMP3-REEP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CHMP3-REEP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CHMP3-REEP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHMP3

GO:0039702

viral budding via host ESCRT complex

24878737

HgeneCHMP3

GO:0051258

protein polymerization

23051622

TgeneREEP1

GO:0051205

protein insertion into membrane

15550249


check buttonFusion gene breakpoints across CHMP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across REEP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-8355-01ACHMP3chr2

86790427

-REEP1chr2

86459925

-


Top

Fusion Gene ORF analysis for CHMP3-REEP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263856ENST00000473407CHMP3chr2

86790427

-REEP1chr2

86459925

-
5CDS-5UTRENST00000409727ENST00000473407CHMP3chr2

86790427

-REEP1chr2

86459925

-
5UTR-3CDSENST00000409225ENST00000165698CHMP3chr2

86790427

-REEP1chr2

86459925

-
5UTR-3CDSENST00000409225ENST00000535845CHMP3chr2

86790427

-REEP1chr2

86459925

-
5UTR-3CDSENST00000409225ENST00000538924CHMP3chr2

86790427

-REEP1chr2

86459925

-
5UTR-3CDSENST00000409225ENST00000540790CHMP3chr2

86790427

-REEP1chr2

86459925

-
5UTR-3CDSENST00000409225ENST00000541910CHMP3chr2

86790427

-REEP1chr2

86459925

-
5UTR-5UTRENST00000409225ENST00000473407CHMP3chr2

86790427

-REEP1chr2

86459925

-
Frame-shiftENST00000263856ENST00000541910CHMP3chr2

86790427

-REEP1chr2

86459925

-
Frame-shiftENST00000409727ENST00000541910CHMP3chr2

86790427

-REEP1chr2

86459925

-
In-frameENST00000263856ENST00000165698CHMP3chr2

86790427

-REEP1chr2

86459925

-
In-frameENST00000263856ENST00000535845CHMP3chr2

86790427

-REEP1chr2

86459925

-
In-frameENST00000263856ENST00000538924CHMP3chr2

86790427

-REEP1chr2

86459925

-
In-frameENST00000263856ENST00000540790CHMP3chr2

86790427

-REEP1chr2

86459925

-
In-frameENST00000409727ENST00000165698CHMP3chr2

86790427

-REEP1chr2

86459925

-
In-frameENST00000409727ENST00000535845CHMP3chr2

86790427

-REEP1chr2

86459925

-
In-frameENST00000409727ENST00000538924CHMP3chr2

86790427

-REEP1chr2

86459925

-
In-frameENST00000409727ENST00000540790CHMP3chr2

86790427

-REEP1chr2

86459925

-
intron-3CDSENST00000439940ENST00000165698CHMP3chr2

86790427

-REEP1chr2

86459925

-
intron-3CDSENST00000439940ENST00000535845CHMP3chr2

86790427

-REEP1chr2

86459925

-
intron-3CDSENST00000439940ENST00000538924CHMP3chr2

86790427

-REEP1chr2

86459925

-
intron-3CDSENST00000439940ENST00000540790CHMP3chr2

86790427

-REEP1chr2

86459925

-
intron-3CDSENST00000439940ENST00000541910CHMP3chr2

86790427

-REEP1chr2

86459925

-
intron-3CDSENST00000494623ENST00000165698CHMP3chr2

86790427

-REEP1chr2

86459925

-
intron-3CDSENST00000494623ENST00000535845CHMP3chr2

86790427

-REEP1chr2

86459925

-
intron-3CDSENST00000494623ENST00000538924CHMP3chr2

86790427

-REEP1chr2

86459925

-
intron-3CDSENST00000494623ENST00000540790CHMP3chr2

86790427

-REEP1chr2

86459925

-
intron-3CDSENST00000494623ENST00000541910CHMP3chr2

86790427

-REEP1chr2

86459925

-
intron-5UTRENST00000439940ENST00000473407CHMP3chr2

86790427

-REEP1chr2

86459925

-
intron-5UTRENST00000494623ENST00000473407CHMP3chr2

86790427

-REEP1chr2

86459925

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263856CHMP3chr286790427-ENST00000165698REEP1chr286459925-347017423271995110
ENST00000263856CHMP3chr286790427-ENST00000535845REEP1chr286459925-346417423271995110
ENST00000263856CHMP3chr286790427-ENST00000538924REEP1chr286459925-346417423271995110
ENST00000263856CHMP3chr286790427-ENST00000540790REEP1chr286459925-4991741731398
ENST00000409727CHMP3chr286790427-ENST00000165698REEP1chr286459925-33677122241892110
ENST00000409727CHMP3chr286790427-ENST00000535845REEP1chr286459925-33617122241892110
ENST00000409727CHMP3chr286790427-ENST00000538924REEP1chr286459925-33617122241892110
ENST00000409727CHMP3chr286790427-ENST00000540790REEP1chr286459925-396713632094

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263856ENST00000165698CHMP3chr286790427-REEP1chr286459925-0.562890950.43710905
ENST00000263856ENST00000535845CHMP3chr286790427-REEP1chr286459925-0.412143140.5878568
ENST00000263856ENST00000538924CHMP3chr286790427-REEP1chr286459925-0.412143140.5878568
ENST00000263856ENST00000540790CHMP3chr286790427-REEP1chr286459925-0.745656550.25434342
ENST00000409727ENST00000165698CHMP3chr286790427-REEP1chr286459925-0.57412890.42587107
ENST00000409727ENST00000535845CHMP3chr286790427-REEP1chr286459925-0.423344460.5766555
ENST00000409727ENST00000538924CHMP3chr286790427-REEP1chr286459925-0.423344460.5766555
ENST00000409727ENST00000540790CHMP3chr286790427-REEP1chr286459925-0.84561090.15438907

Top

Fusion Genomic Features for CHMP3-REEP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for CHMP3-REEP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:86790427/chr2:86459925)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneREEP1chr2:86790427chr2:86459925ENST0000016569847170_173139202.0Compositional biasNote=Poly-Pro
TgeneREEP1chr2:86790427chr2:86459925ENST0000053584536170_173112175.0Compositional biasNote=Poly-Pro
TgeneREEP1chr2:86790427chr2:86459925ENST0000053892447170_173146209.0Compositional biasNote=Poly-Pro
TgeneREEP1chr2:86790427chr2:86459925ENST0000054191025170_17360144.0Compositional biasNote=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHMP3chr2:86790427chr2:86459925ENST00000263856-16141_22215223.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP3chr2:86790427chr2:86459925ENST00000263856-1622_5415223.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP3chr2:86790427chr2:86459925ENST00000409225-15141_2220157.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP3chr2:86790427chr2:86459925ENST00000409225-1522_540157.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP3chr2:86790427chr2:86459925ENST00000409727-16141_22215183.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP3chr2:86790427chr2:86459925ENST00000409727-1622_5415183.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP3chr2:86790427chr2:86459925ENST00000439940-18141_2220252.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP3chr2:86790427chr2:86459925ENST00000439940-1822_540252.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP3chr2:86790427chr2:86459925ENST00000263856-16201_21115223.0MotifNote=MIT-interacting motif
HgeneCHMP3chr2:86790427chr2:86459925ENST00000409225-15201_2110157.0MotifNote=MIT-interacting motif
HgeneCHMP3chr2:86790427chr2:86459925ENST00000409727-16201_21115183.0MotifNote=MIT-interacting motif
HgeneCHMP3chr2:86790427chr2:86459925ENST00000439940-18201_2110252.0MotifNote=MIT-interacting motif
HgeneCHMP3chr2:86790427chr2:86459925ENST00000263856-1659_6415223.0RegionNote=Important for autoinhibitory function
HgeneCHMP3chr2:86790427chr2:86459925ENST00000409225-1559_640157.0RegionNote=Important for autoinhibitory function
HgeneCHMP3chr2:86790427chr2:86459925ENST00000409727-1659_6415183.0RegionNote=Important for autoinhibitory function
HgeneCHMP3chr2:86790427chr2:86459925ENST00000439940-1859_640252.0RegionNote=Important for autoinhibitory function
TgeneREEP1chr2:86790427chr2:86459925ENST00000165698471_21139202.0TransmembraneHelical
TgeneREEP1chr2:86790427chr2:86459925ENST000001656984735_55139202.0TransmembraneHelical
TgeneREEP1chr2:86790427chr2:86459925ENST00000535845361_21112175.0TransmembraneHelical
TgeneREEP1chr2:86790427chr2:86459925ENST000005358453635_55112175.0TransmembraneHelical
TgeneREEP1chr2:86790427chr2:86459925ENST00000538924471_21146209.0TransmembraneHelical
TgeneREEP1chr2:86790427chr2:86459925ENST000005389244735_55146209.0TransmembraneHelical
TgeneREEP1chr2:86790427chr2:86459925ENST00000541910251_2160144.0TransmembraneHelical
TgeneREEP1chr2:86790427chr2:86459925ENST000005419102535_5560144.0TransmembraneHelical


Top

Fusion Gene Sequence for CHMP3-REEP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16540_16540_1_CHMP3-REEP1_CHMP3_chr2_86790427_ENST00000263856_REEP1_chr2_86459925_ENST00000165698_length(transcript)=3470nt_BP=174nt
TGCCGCCGCTCCCTACTCTGGGGGTTGGGACTACCTCCTTTTCCGCGGGCCCCGCCCAGGCGGCTGCCCGTGACCTGCCTGGGCGCGGGG
AACTGAAAGCCGGAAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAG
GGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCA
CCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCC
TAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATC
CACAGAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACA
AACATGGCCTTTTCTCTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAA
GGTAGTAGGGGCGGGGGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTT
TTAGAAAGATAAGAGAATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCA
AACACAGCATTTTTTACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAA
TGGACTTGCAAGGGCTGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCA
GATGTGCTTATAAAGCTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAG
TCAAAAGACCAGACAAGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAA
AGAGAAGAGTCACAGGAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCT
TGGTGCAATTTCTTGAGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGAC
CAGTGCTGCCGATTTCCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAAC
AAACACACAAAAAACTGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCT
AGAATGGTTTTGGAGCTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCT
GGCCTGTGCAGAATGTAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAG
GGGAATAAGGCATTCTCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGG
TAGCTGCTCTCCCCACTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCA
GTGGTCACAACCCAGTTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATAT
AGAACTTACTGTCAGTCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACA
CATTAGCTGGATCTTAGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGT
TCCTCTGAAGGTGATTTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGT
TTGCTCATGTTCTGTGCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCA
GACAGAAGAAGAATATACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAA
AAAAAAAAAGCTTACACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTG
AACAACCTATATTTTCGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGA
AGCGCTCTATTCTCAGACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGT
AACTATTTTTCCTTCAAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGG
CAAAATGTGTTTACGTATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTG
GTGTTCTGTCTAGAGGATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTA
ATGTTCATGTCATAACTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTT
AGTCATAATCCCTCCTGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTT
GTGATAAGAGTGCTTGTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTC
ATCCTCTAACAGTGTACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAAT
GATCTGTAATAAAATAGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATA
ATGCCTGATACACATCTTGAATAAAGTCTTAACATTTTTCTTTTAAAAAA

>16540_16540_1_CHMP3-REEP1_CHMP3_chr2_86790427_ENST00000263856_REEP1_chr2_86459925_ENST00000165698_length(amino acids)=110AA_BP=
MSTKKTFSVFLNRFRYWWVWGTEHEQTASVYPLSHKFAFRYIFLYPFANYKITFRGTMGRWDSNMHIWQQSASNQTLSGVAKIQLMCHQQ
RPLICVCVVMEQFLIGPVYS

--------------------------------------------------------------
>16540_16540_2_CHMP3-REEP1_CHMP3_chr2_86790427_ENST00000263856_REEP1_chr2_86459925_ENST00000535845_length(transcript)=3464nt_BP=174nt
TGCCGCCGCTCCCTACTCTGGGGGTTGGGACTACCTCCTTTTCCGCGGGCCCCGCCCAGGCGGCTGCCCGTGACCTGCCTGGGCGCGGGG
AACTGAAAGCCGGAAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAG
GGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCA
CCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCC
TAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATC
CACAGAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACA
AACATGGCCTTTTCTCTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAA
GGTAGTAGGGGCGGGGGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTT
TTAGAAAGATAAGAGAATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCA
AACACAGCATTTTTTACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAA
TGGACTTGCAAGGGCTGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCA
GATGTGCTTATAAAGCTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAG
TCAAAAGACCAGACAAGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAA
AGAGAAGAGTCACAGGAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCT
TGGTGCAATTTCTTGAGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGAC
CAGTGCTGCCGATTTCCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAAC
AAACACACAAAAAACTGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCT
AGAATGGTTTTGGAGCTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCT
GGCCTGTGCAGAATGTAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAG
GGGAATAAGGCATTCTCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGG
TAGCTGCTCTCCCCACTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCA
GTGGTCACAACCCAGTTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATAT
AGAACTTACTGTCAGTCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACA
CATTAGCTGGATCTTAGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGT
TCCTCTGAAGGTGATTTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGT
TTGCTCATGTTCTGTGCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCA
GACAGAAGAAGAATATACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAA
AAAAAAAAAGCTTACACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTG
AACAACCTATATTTTCGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGA
AGCGCTCTATTCTCAGACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGT
AACTATTTTTCCTTCAAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGG
CAAAATGTGTTTACGTATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTG
GTGTTCTGTCTAGAGGATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTA
ATGTTCATGTCATAACTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTT
AGTCATAATCCCTCCTGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTT
GTGATAAGAGTGCTTGTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTC
ATCCTCTAACAGTGTACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAAT
GATCTGTAATAAAATAGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATA
ATGCCTGATACACATCTTGAATAAAGTCTTAACATTTTTCTTTT

>16540_16540_2_CHMP3-REEP1_CHMP3_chr2_86790427_ENST00000263856_REEP1_chr2_86459925_ENST00000535845_length(amino acids)=110AA_BP=
MSTKKTFSVFLNRFRYWWVWGTEHEQTASVYPLSHKFAFRYIFLYPFANYKITFRGTMGRWDSNMHIWQQSASNQTLSGVAKIQLMCHQQ
RPLICVCVVMEQFLIGPVYS

--------------------------------------------------------------
>16540_16540_3_CHMP3-REEP1_CHMP3_chr2_86790427_ENST00000263856_REEP1_chr2_86459925_ENST00000538924_length(transcript)=3464nt_BP=174nt
TGCCGCCGCTCCCTACTCTGGGGGTTGGGACTACCTCCTTTTCCGCGGGCCCCGCCCAGGCGGCTGCCCGTGACCTGCCTGGGCGCGGGG
AACTGAAAGCCGGAAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAG
GGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCA
CCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCC
TAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATC
CACAGAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACA
AACATGGCCTTTTCTCTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAA
GGTAGTAGGGGCGGGGGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTT
TTAGAAAGATAAGAGAATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCA
AACACAGCATTTTTTACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAA
TGGACTTGCAAGGGCTGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCA
GATGTGCTTATAAAGCTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAG
TCAAAAGACCAGACAAGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAA
AGAGAAGAGTCACAGGAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCT
TGGTGCAATTTCTTGAGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGAC
CAGTGCTGCCGATTTCCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAAC
AAACACACAAAAAACTGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCT
AGAATGGTTTTGGAGCTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCT
GGCCTGTGCAGAATGTAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAG
GGGAATAAGGCATTCTCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGG
TAGCTGCTCTCCCCACTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCA
GTGGTCACAACCCAGTTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATAT
AGAACTTACTGTCAGTCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACA
CATTAGCTGGATCTTAGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGT
TCCTCTGAAGGTGATTTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGT
TTGCTCATGTTCTGTGCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCA
GACAGAAGAAGAATATACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAA
AAAAAAAAAGCTTACACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTG
AACAACCTATATTTTCGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGA
AGCGCTCTATTCTCAGACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGT
AACTATTTTTCCTTCAAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGG
CAAAATGTGTTTACGTATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTG
GTGTTCTGTCTAGAGGATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTA
ATGTTCATGTCATAACTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTT
AGTCATAATCCCTCCTGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTT
GTGATAAGAGTGCTTGTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTC
ATCCTCTAACAGTGTACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAAT
GATCTGTAATAAAATAGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATA
ATGCCTGATACACATCTTGAATAAAGTCTTAACATTTTTCTTTT

>16540_16540_3_CHMP3-REEP1_CHMP3_chr2_86790427_ENST00000263856_REEP1_chr2_86459925_ENST00000538924_length(amino acids)=110AA_BP=
MSTKKTFSVFLNRFRYWWVWGTEHEQTASVYPLSHKFAFRYIFLYPFANYKITFRGTMGRWDSNMHIWQQSASNQTLSGVAKIQLMCHQQ
RPLICVCVVMEQFLIGPVYS

--------------------------------------------------------------
>16540_16540_4_CHMP3-REEP1_CHMP3_chr2_86790427_ENST00000263856_REEP1_chr2_86459925_ENST00000540790_length(transcript)=499nt_BP=174nt
TGCCGCCGCTCCCTACTCTGGGGGTTGGGACTACCTCCTTTTCCGCGGGCCCCGCCCAGGCGGCTGCCCGTGACCTGCCTGGGCGCGGGG
AACTGAAAGCCGGAAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAG
GGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCA
CCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCC
TAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATC
CACAGAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAACATAG

>16540_16540_4_CHMP3-REEP1_CHMP3_chr2_86790427_ENST00000263856_REEP1_chr2_86459925_ENST00000540790_length(amino acids)=98AA_BP=1
MGVGTTSFSAGPAQAAARDLPGRGELKAGRGKTGSVRHGAVWKDPGEAAQRTGTGCLIGETAELQHAGPHHHQGRRRPCSLGPPTTGVWA
GQRQTRPA

--------------------------------------------------------------
>16540_16540_5_CHMP3-REEP1_CHMP3_chr2_86790427_ENST00000409727_REEP1_chr2_86459925_ENST00000165698_length(transcript)=3367nt_BP=71nt
AAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAGGGTGCCTTATCGG
AGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTG
GGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCCTAGAATCCTTCGA
TCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTC
TTCTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTT
CTCTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCG
GGGGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAG
AGAATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTT
TTACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGG
GCTGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAA
AGCTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGA
CAAGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCAC
AGGAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCT
TGAGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGAT
TTCCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAA
ACTGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGG
AGCTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAA
TGTAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCAT
TCTCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCC
CACTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCC
AGTTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTC
AGTCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATC
TTAGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTG
ATTTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCT
GTGCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAA
TATACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTT
ACACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATT
TTCGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCT
CAGACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCT
TCAAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTA
CGTATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAG
AGGATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCAT
AACTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCT
CCTGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGC
TTGTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGT
GTACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAA
ATAGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACAC
ATCTTGAATAAAGTCTTAACATTTTTCTTTTAAAAAA

>16540_16540_5_CHMP3-REEP1_CHMP3_chr2_86790427_ENST00000409727_REEP1_chr2_86459925_ENST00000165698_length(amino acids)=110AA_BP=
MSTKKTFSVFLNRFRYWWVWGTEHEQTASVYPLSHKFAFRYIFLYPFANYKITFRGTMGRWDSNMHIWQQSASNQTLSGVAKIQLMCHQQ
RPLICVCVVMEQFLIGPVYS

--------------------------------------------------------------
>16540_16540_6_CHMP3-REEP1_CHMP3_chr2_86790427_ENST00000409727_REEP1_chr2_86459925_ENST00000535845_length(transcript)=3361nt_BP=71nt
AAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAGGGTGCCTTATCGG
AGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTG
GGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCCTAGAATCCTTCGA
TCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTC
TTCTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTT
CTCTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCG
GGGGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAG
AGAATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTT
TTACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGG
GCTGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAA
AGCTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGA
CAAGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCAC
AGGAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCT
TGAGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGAT
TTCCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAA
ACTGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGG
AGCTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAA
TGTAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCAT
TCTCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCC
CACTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCC
AGTTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTC
AGTCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATC
TTAGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTG
ATTTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCT
GTGCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAA
TATACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTT
ACACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATT
TTCGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCT
CAGACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCT
TCAAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTA
CGTATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAG
AGGATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCAT
AACTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCT
CCTGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGC
TTGTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGT
GTACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAA
ATAGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACAC
ATCTTGAATAAAGTCTTAACATTTTTCTTTT

>16540_16540_6_CHMP3-REEP1_CHMP3_chr2_86790427_ENST00000409727_REEP1_chr2_86459925_ENST00000535845_length(amino acids)=110AA_BP=
MSTKKTFSVFLNRFRYWWVWGTEHEQTASVYPLSHKFAFRYIFLYPFANYKITFRGTMGRWDSNMHIWQQSASNQTLSGVAKIQLMCHQQ
RPLICVCVVMEQFLIGPVYS

--------------------------------------------------------------
>16540_16540_7_CHMP3-REEP1_CHMP3_chr2_86790427_ENST00000409727_REEP1_chr2_86459925_ENST00000538924_length(transcript)=3361nt_BP=71nt
AAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAGGGTGCCTTATCGG
AGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTG
GGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCCTAGAATCCTTCGA
TCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTC
TTCTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTT
CTCTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCG
GGGGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAG
AGAATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTT
TTACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGG
GCTGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAA
AGCTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGA
CAAGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCAC
AGGAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCT
TGAGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGAT
TTCCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAA
ACTGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGG
AGCTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAA
TGTAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCAT
TCTCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCC
CACTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCC
AGTTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTC
AGTCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATC
TTAGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTG
ATTTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCT
GTGCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAA
TATACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTT
ACACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATT
TTCGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCT
CAGACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCT
TCAAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTA
CGTATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAG
AGGATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCAT
AACTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCT
CCTGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGC
TTGTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGT
GTACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAA
ATAGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACAC
ATCTTGAATAAAGTCTTAACATTTTTCTTTT

>16540_16540_7_CHMP3-REEP1_CHMP3_chr2_86790427_ENST00000409727_REEP1_chr2_86459925_ENST00000538924_length(amino acids)=110AA_BP=
MSTKKTFSVFLNRFRYWWVWGTEHEQTASVYPLSHKFAFRYIFLYPFANYKITFRGTMGRWDSNMHIWQQSASNQTLSGVAKIQLMCHQQ
RPLICVCVVMEQFLIGPVYS

--------------------------------------------------------------
>16540_16540_8_CHMP3-REEP1_CHMP3_chr2_86790427_ENST00000409727_REEP1_chr2_86459925_ENST00000540790_length(transcript)=396nt_BP=71nt
AAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAGGGTGCCTTATCGG
AGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTG
GGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCCTAGAATCCTTCGA
TCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTC
TTCTCTGCCTTAAAGAGCTATTCACTAATAACATAG

>16540_16540_8_CHMP3-REEP1_CHMP3_chr2_86790427_ENST00000409727_REEP1_chr2_86459925_ENST00000540790_length(amino acids)=94AA_BP=1
MERPRRSRPKNWDRVPYRRDCGASACRTSPPSGETAPLLPRAPHHRGLGGPAANTASLRCPGVLLRALAAQAPPRILRSRFRKKSTSSSA
TETT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CHMP3-REEP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCHMP3chr2:86790427chr2:86459925ENST00000263856-16203_20715.0223.0STAMBP
HgeneCHMP3chr2:86790427chr2:86459925ENST00000409225-15203_2070157.0STAMBP
HgeneCHMP3chr2:86790427chr2:86459925ENST00000409727-16203_20715.0183.0STAMBP
HgeneCHMP3chr2:86790427chr2:86459925ENST00000439940-18203_2070252.0STAMBP
HgeneCHMP3chr2:86790427chr2:86459925ENST00000263856-16151_22215.0223.0VPS4A
HgeneCHMP3chr2:86790427chr2:86459925ENST00000409225-15151_2220157.0VPS4A
HgeneCHMP3chr2:86790427chr2:86459925ENST00000409727-16151_22215.0183.0VPS4A
HgeneCHMP3chr2:86790427chr2:86459925ENST00000439940-18151_2220252.0VPS4A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CHMP3-REEP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CHMP3-REEP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC1853247SPASTIC PARAPLEGIA 31, AUTOSOMAL DOMINANT7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC3553656NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE VB2GENOMICS_ENGLAND
TgeneC0004238Atrial Fibrillation1CTD_human
TgeneC0235480Paroxysmal atrial fibrillation1CTD_human
TgeneC0878544Cardiomyopathies1GENOMICS_ENGLAND
TgeneC1833308NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE V1CTD_human;ORPHANET
TgeneC2585653Persistent atrial fibrillation1CTD_human
TgeneC3468561familial atrial fibrillation1CTD_human