Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CAB39-RHBDD1 (FusionGDB2 ID:HG51719TG84236)

Fusion Gene Summary for CAB39-RHBDD1

check button Fusion gene summary
Fusion gene informationFusion gene name: CAB39-RHBDD1
Fusion gene ID: hg51719tg84236
HgeneTgene
Gene symbol

CAB39

RHBDD1

Gene ID

51719

84236

Gene namecalcium binding protein 39rhomboid domain containing 1
SynonymsCGI-66|MO25RHBDL4|RRP4
Cytomap('CAB39')('RHBDD1')

2q37.1

2q36.3

Type of geneprotein-codingprotein-coding
Descriptioncalcium-binding protein 39MO25alpharhomboid-related protein 4rhomboid domain-containing protein 1rhomboid-like protein 4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000258418, ENST00000409788, 
ENST00000410084, ENST00000484398, 
Fusion gene scores* DoF score7 X 4 X 5=1408 X 7 X 4=224
# samples 98
** MAII scorelog2(9/140*10)=-0.637429920615292
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAB39 [Title/Abstract] AND RHBDD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCAB39(231624830)-RHBDD1(227860147), # samples:2
Anticipated loss of major functional domain due to fusion event.CAB39-RHBDD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAB39-RHBDD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAB39-RHBDD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CAB39-RHBDD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CAB39-RHBDD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAB39

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

24393035

HgeneCAB39

GO:0018105

peptidyl-serine phosphorylation

24393035

HgeneCAB39

GO:0023014

signal transduction by protein phosphorylation

24393035

HgeneCAB39

GO:0035556

intracellular signal transduction

24393035

HgeneCAB39

GO:0071902

positive regulation of protein serine/threonine kinase activity

19892943|24393035


check buttonFusion gene breakpoints across CAB39 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RHBDD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A8BX-01ACAB39chr2

231624830

-RHBDD1chr2

227860147

+
ChimerDB4SARCTCGA-DX-A8BX-01ACAB39chr2

231624830

+RHBDD1chr2

227860147

+


Top

Fusion Gene ORF analysis for CAB39-RHBDD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000258418ENST00000493526CAB39chr2

231624830

+RHBDD1chr2

227860147

+
5CDS-3UTRENST00000409788ENST00000493526CAB39chr2

231624830

+RHBDD1chr2

227860147

+
5CDS-3UTRENST00000410084ENST00000493526CAB39chr2

231624830

+RHBDD1chr2

227860147

+
5CDS-intronENST00000258418ENST00000409053CAB39chr2

231624830

+RHBDD1chr2

227860147

+
5CDS-intronENST00000409788ENST00000409053CAB39chr2

231624830

+RHBDD1chr2

227860147

+
5CDS-intronENST00000410084ENST00000409053CAB39chr2

231624830

+RHBDD1chr2

227860147

+
Frame-shiftENST00000258418ENST00000392062CAB39chr2

231624830

+RHBDD1chr2

227860147

+
Frame-shiftENST00000409788ENST00000392062CAB39chr2

231624830

+RHBDD1chr2

227860147

+
Frame-shiftENST00000410084ENST00000392062CAB39chr2

231624830

+RHBDD1chr2

227860147

+
In-frameENST00000258418ENST00000341329CAB39chr2

231624830

+RHBDD1chr2

227860147

+
In-frameENST00000409788ENST00000341329CAB39chr2

231624830

+RHBDD1chr2

227860147

+
In-frameENST00000410084ENST00000341329CAB39chr2

231624830

+RHBDD1chr2

227860147

+
intron-3CDSENST00000484398ENST00000341329CAB39chr2

231624830

+RHBDD1chr2

227860147

+
intron-3CDSENST00000484398ENST00000392062CAB39chr2

231624830

+RHBDD1chr2

227860147

+
intron-3UTRENST00000484398ENST00000493526CAB39chr2

231624830

+RHBDD1chr2

227860147

+
intron-intronENST00000484398ENST00000409053CAB39chr2

231624830

+RHBDD1chr2

227860147

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000258418CAB39chr2231624830+ENST00000341329RHBDD1chr2227860147+43285434302143
ENST00000410084CAB39chr2231624830+ENST00000341329RHBDD1chr2227860147+41974127381100120
ENST00000409788CAB39chr2231624830+ENST00000341329RHBDD1chr2227860147+4453668715185176

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000258418ENST00000341329CAB39chr2231624830+RHBDD1chr2227860147+0.782022060.21797797
ENST00000410084ENST00000341329CAB39chr2231624830+RHBDD1chr2227860147+0.79581270.2041873
ENST00000409788ENST00000341329CAB39chr2231624830+RHBDD1chr2227860147+0.8085170.19148298

Top

Fusion Genomic Features for CAB39-RHBDD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CAB39chr2231624830+RHBDD1chr2227860146+1.41E-081
CAB39chr2231624830+RHBDD1chr2227860146+1.41E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for CAB39-RHBDD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:231624830/chr2:227860147)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRHBDD1chr2:231624830chr2:227860147ENST0000034132957301_315285316.0RegionVCP/p97-interacting motif (VIM)
TgeneRHBDD1chr2:231624830chr2:227860147ENST0000039206279301_315285316.0RegionVCP/p97-interacting motif (VIM)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRHBDD1chr2:231624830chr2:227860147ENST0000034132957269_284285316.0RegionUbiquitin-binding domain (UBD)
TgeneRHBDD1chr2:231624830chr2:227860147ENST0000039206279269_284285316.0RegionUbiquitin-binding domain (UBD)
TgeneRHBDD1chr2:231624830chr2:227860147ENST0000034132957128_138285316.0Topological domainCytoplasmic
TgeneRHBDD1chr2:231624830chr2:227860147ENST0000034132957158_180285316.0Topological domainExtracellular
TgeneRHBDD1chr2:231624830chr2:227860147ENST00000341329571_21285316.0Topological domainCytoplasmic
TgeneRHBDD1chr2:231624830chr2:227860147ENST0000034132957202_315285316.0Topological domainCytoplasmic
TgeneRHBDD1chr2:231624830chr2:227860147ENST000003413295743_106285316.0Topological domainExtracellular
TgeneRHBDD1chr2:231624830chr2:227860147ENST0000039206279128_138285316.0Topological domainCytoplasmic
TgeneRHBDD1chr2:231624830chr2:227860147ENST0000039206279158_180285316.0Topological domainExtracellular
TgeneRHBDD1chr2:231624830chr2:227860147ENST00000392062791_21285316.0Topological domainCytoplasmic
TgeneRHBDD1chr2:231624830chr2:227860147ENST0000039206279202_315285316.0Topological domainCytoplasmic
TgeneRHBDD1chr2:231624830chr2:227860147ENST000003920627943_106285316.0Topological domainExtracellular
TgeneRHBDD1chr2:231624830chr2:227860147ENST0000034132957107_127285316.0TransmembraneHelical
TgeneRHBDD1chr2:231624830chr2:227860147ENST0000034132957139_157285316.0TransmembraneHelical
TgeneRHBDD1chr2:231624830chr2:227860147ENST0000034132957181_201285316.0TransmembraneHelical
TgeneRHBDD1chr2:231624830chr2:227860147ENST000003413295722_42285316.0TransmembraneHelical
TgeneRHBDD1chr2:231624830chr2:227860147ENST0000039206279107_127285316.0TransmembraneHelical
TgeneRHBDD1chr2:231624830chr2:227860147ENST0000039206279139_157285316.0TransmembraneHelical
TgeneRHBDD1chr2:231624830chr2:227860147ENST0000039206279181_201285316.0TransmembraneHelical
TgeneRHBDD1chr2:231624830chr2:227860147ENST000003920627922_42285316.0TransmembraneHelical


Top

Fusion Gene Sequence for CAB39-RHBDD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12223_12223_1_CAB39-RHBDD1_CAB39_chr2_231624830_ENST00000258418_RHBDD1_chr2_227860147_ENST00000341329_length(transcript)=4328nt_BP=543nt
GTGCGCACGTCAAAGCCGGGCTCGGGCCGCAAGCGGGGCGAGGGGTTCGGGGAGCGGCGCGGCCTGGGAGACACAGAGCCTTCAGGCGCC
GGGGCGGGGGCACAGGCGAAGACTAAGGCGGCGCCGGGCCCCACAGCAGCAGCCGCAGCCCAAGCGAGCGCAGCAGCGCGGCGGCAGCCG
CGGGAGCCCCTGGGCAGCCGTCCGCCCGCGCAGCCGCCGCCGCCGCGGGAGCCCGTCGCCGGGAGCAGGAGCGGGCGGAAGACAACGGAG
GGGCCGAGCGTCCGAGCCACTCCGCGGGGACCGAACGAGCAGCCCGAAGCGGCGGCGGCCGAGGACGGGGACAGCGACGACGCGGAGGCA
GAGAAGGGAACGCCCGGCCCAGCCCCGTAGCACAGGCGGAGTGCAGCGGAGGCCCCTGCCGCTGCCGTCATGCCGTTCCCGTTTGGGAAG
TCTCACAAATCTCCAGCAGACATTGTGAAGAATCTGAAGGAGAGCATGGCTGTTCTGGAAAAGCAAGACATTTCTGATAAAAAAGCAGAA
AAGGAAATACCAGAAATAGCCCACCACCCTACGGGTTTCATCTCTCACCAGAAGAAATGAGGAGACAGCGGCTTCACAGATTCGATAGCC
AGTGAGGTGGCATCTTGGGAAGACATGGCCTATTCGTGTAATTATTGCCCATTTGGCTCATTCCCCAAGCCCCTAATTCATTTTAATTCA
TTTTAAACAAAAGCAGAGTACACCGGTATTGCTCCAGATCGCTCACATCACCTGGGACAGTCCCATGGCCCCTATGAGTCAACTCACAGC
TTGCGGGGAGTGGGCCTTCTCCTGGCCTTGTTCTTGCTCATAAACAGGTCACTTCCTCCATGAAGAGACCAGTTTCCACGCTCCCATCTC
TCACTGCTGACTCAGCGATGCCTCTGCCTCGGTCTGCTTTTGAAGACTGTGACCTTCACCAGGAGGTTTTACTTACACCAGTCGGGAAGA
TTAGTCCCTCATTCTGCCTGGAGTGCCCCGTGTTTGACTTGGCAGCGGGTGTGGAGCCATCCCCGCGTCCTCCTGGCGCATTGCCACTGT
GGCTGTCCAGGAACAGGATGTGGCTGCCTTGGCCGAATGTTGTCCTACTCTCCCCAACCCCGGCGCCTCAGCTCCTCAGCTCCTCGGGCC
CCTGCGTCTGGCTGGTGTTTGCAGGGCTTTCGCTCTGCTCTGGTATTGCTCTGCCTTTATAGAAAGTCTTATTGAAGAAGTGTAAGAAAG
ACCTAAGGTGGGGAAGACTCCTACACACACCATTAGTATCAGTGACACCAGCAATGTAGGTTCCCAGCCCCTTCCCAGTGGCAGCTTGTG
TGTCCAGGAGATAGGACATCATTTAACGCATCAGCAAAGTAGCAGCAGATGCCACATACAGAGTAGAGCGAAGGCATTTGGTGGATCGGT
CACTAGAGATCTATCTTGCAGAAAGTATGTTTTTCCTCATAAAAGTGCCTCTTAATTGGCCATTGTACCAGCCACTTGTCCTAGCCAAAT
GTCCAAAACACGCCCTTGGGCCCCGCCACGTTACAATCCACAGATTGTCTGTCTGAGTCGTTTAAGGCATTTCCTGGTGCTTGTGTTCCA
TGAATAAAAGGACAAAGTCAGAAGATCACTGATGTCTTACTGTCAACAGAGATATTTTAAAAGAGAGAAGCAGGAAAAGATCTTCCTTTT
TTGATCTACAACTTATATAGTTTTCTGATTATGCACATAATAGATATGCCTTCCAGATGCATAAGGCAAACATCTGGAAAGAAATATACC
CAAATCTTAGCAGGGGTTATCTTTGGGAGTGGAGTACATGGGATTTTGCTTTCTTCATTTTTATAATTTTATATTACTGTCTTGGAAGAT
GTGTTTATGTGTGTGTGTTACTTTTACAATCAGGAAAACATATTTAATAACATATAGTCAAGAAAACAGACTTAAAAATAAATACTATGT
GTCCATTGAGAAAATTCACAATATAAACAGAAATACAAATAAATACATACACAATTTTAAAGTCACCTGTAGCCCTACCCTTAGAGGTAC
CCAGGGTTAACATTTTGGTGGTATTGTCTTATCAATTTTTCCGTTGATACATTCAGCAAATTTGGAGCACATTGACCATGGAGTTTTGTG
TCCAAATCCAATCTGAATTTACCTGGAAGAGGCCTTGACACCTGCATGGAAATGAGCTAAGAAAACCACTGGAGCCTTGGGAGCTCTTTG
GCCTCCTGGCTGGCCCAGTAATATCTGAGCTCCTTTGGTTAATTTATAACTGATATAAAACTACATCTTCTTTATAATATAAATTGTACC
TGTGAGTCTAGAAGCTTTAAATGTGTTTAAATTAAAATATTCAAGCTAAATGTTACTGCTCTCTCCCAAATTCTGTAAGTTTGACTCCCG
TTACCCCAATTAGAAGTAACTTCTTTGTTTCATGCCACTTTTATAGCATTTGGTAATTCTGCTATAACACATCTTGCCCCTATTATTAAC
TGTGCACAGCTACACAAAGGTGTGCCTTCTACGTGGGAACATGGATTGTGAATGACTCTGTAATGAGGCCTGAGTCTTAGTTATCTTTCC
ACTCACTCCCCGTCTCCCCTTTCCAACCCCAAAGGCTCACGATAGGGGCTCACTAAATGTCAGTGTTTCACCAAAGTATTTTTTCCATTG
TATTAAGAGTCCAGTCACTGTATATGGAAGTATTTTATTTTTTATTTTTTTATATCACTTGAGTCCACTAGTAGTACTTCCTTGCTCTGT
TTGACTTGTCAGATACAAAGACACGGGATTAGATTTTGGGTGGTAAAATTGTGATACGCATGGCTGTTGATGGAGTGGAACATCTTAGTG
ATGTGAGAAAGGTCATTTTAGTTATAAATGTAAACCAATTACTTTAGCACAACAATAAAGATGTTCTGGAAATTATTATAATTATTTTAG
TTAATGGACTTGCCTGTAACAAGTGCTTATGTTTGGAATGTCCATTTTATTTTATTTTCCTCTACAATAAGGAATCCCTAAAGTTATGCC
AACAAACTGGAATTGGATTGAGAAAGACAAAAGCAAGTGAGCAAGTGTATTAGACTAATTATCTCTAGTAGGGAATAAGCACTTAGAGCT
AATTTTTTAATTTGGTTTATTTATTAGTAGCTCCCTGATTGTCTGTTAAGCCCCTGGTTCCCACAGTTTGGTGTGGTCAGTCAACTTAAG
CGACCTTTTAATGCAGAATCTTTACTTGGTTCTGAAGAGGAGGCAGTAGTTAAAATTGCTTCCTCTTAATGACTCTGAATGTATTGCCTG
TGATTCCAAAGTTGTACATAATTGTTCAGACCTCCTCCATCCTTTTAAATTGCCTGCTGCAGTAAATAACTAGTTTGAGTAGAACTAGAT
CCTGTCTATCTATTTGGCACATGTTCTGCTGCCTGGGGAGTAAGCAAGCTAAAGGGATGAGAAAGACCACCTCCCCCTACCCTGGAAATT
GCACTGCAAGGCAGGGCGAGAATGGGGTAGCTGGCAGACCTGGCCTCCTTGTTCCCAGTCTTAGTTTTTCTTGAGAGATTCAGTATTCAG
TAAAGAATAGCATTCAATTAGTCAAAAAATATATATATAACTTCTTCCTTTCCCTTCCCATGAATCATTGCAGTCATTCCCTAAGTTTCT
TCTCTTTTTTTTTCATGGCTGCTAGTATTTTATTTTAGAATCACAGACTCTCAGCTTAGAGAGTCACAGTATCTCAATTATTTGCTCTGT
TCAATACTTAACAATACCTCCTCACTCAATTCTACATAACTCCAGCTTAGTCTTCCAAAATTCACTTTCATGATGCCACTCAGCATCTCA
AATACCTTTCATTGGCTCTCTGCTGCCAAAGGATAAAGGTCAAAGTCATTAGCCTCAACAGTGGGCTTCAACCAGCCTTTGGACCTCAGC
CCCATTTATCCATCACAGAGGCTGGTAACTAGTCTCACTGCTCAGGCTGTGAGTGTTCCTGATCTTGTGACATTCTGTGCTGTGCTTTTA
CATGGAACAGCTCTTTCCTCTCTCTTGGCCCATTCAGATCCTCCTCATCCAGCCCCCATCTGAATCCTGTAACAGACACAACCACATCTA
CACAGTTTCCACATACCACTTGGAATTGCTGGTTATGCTGCAATGAGAGAATGTCTTTGTCTTTAAATTGTAAGCTTCATGAGGGCAGGG
ACCATCTGTTTCTCTGTCTCTCCTCACAGTGCCTTGAGCAGTACGTTGTCTGGAATGTCAGAACCAATAAATACTTGTGGATTGAAACAA

>12223_12223_1_CAB39-RHBDD1_CAB39_chr2_231624830_ENST00000258418_RHBDD1_chr2_227860147_ENST00000341329_length(amino acids)=143AA_BP=
MTAAAGASAALRLCYGAGPGVPFSASASSLSPSSAAAASGCSFGPRGVARTLGPSVVFRPLLLPATGSRGGGGCAGGRLPRGSRGCRRAA

--------------------------------------------------------------
>12223_12223_2_CAB39-RHBDD1_CAB39_chr2_231624830_ENST00000409788_RHBDD1_chr2_227860147_ENST00000341329_length(transcript)=4453nt_BP=668nt
AGTCGGGCGGGCGGGGAAGTGCGGGCCGGGTCAACTGTCACCGGCTGCACCCGGGCTTCAGCGCCTCGCTCCCGCCCCTGGTAAACTTCC
TGTTGTCGGGAGGCAGATACCAGCTTTGTGACCAATTCAGGAAAATGCCTAACTGATTTCTGGTTAGGAATTGGGCGGTCGGAGCGTTCT
GGAGTTCAATGGAACCACCCCAAGCGCAGACTGCGTGCAGGCGCCGTAGTCGGCCCGCACCGGAGGGATTCAAAGGTGAAGCGGGCCCCG
GTCCCCTCCCCCGAGGAGCTTAGGCTCTGGTGTGAGAGATAAGACGAGAACACAAATAACTGCGATACCGGGAAGGAGGTGATAAGTCCT
GTGAAAGAACGACGGAGTGCTAGAACGGCACCCGGAAAAACCGAACCGATCACTTCTGCCTCGCAGAAACCTGGAAGGCTTCCTGGGCGG
GGGATGCTGAGCAGAGTCTTGAAGGCCTGATGGGATTTAGGAGAGGAGGATTGCAGAAGAGGTAGCACAGGCGGAGTGCAGCGGAGGCCC
CTGCCGCTGCCGTCATGCCGTTCCCGTTTGGGAAGTCTCACAAATCTCCAGCAGACATTGTGAAGAATCTGAAGGAGAGCATGGCTGTTC
TGGAAAAGCAAGACATTTCTGATAAAAAAGCAGAAAAGGAAATACCAGAAATAGCCCACCACCCTACGGGTTTCATCTCTCACCAGAAGA
AATGAGGAGACAGCGGCTTCACAGATTCGATAGCCAGTGAGGTGGCATCTTGGGAAGACATGGCCTATTCGTGTAATTATTGCCCATTTG
GCTCATTCCCCAAGCCCCTAATTCATTTTAATTCATTTTAAACAAAAGCAGAGTACACCGGTATTGCTCCAGATCGCTCACATCACCTGG
GACAGTCCCATGGCCCCTATGAGTCAACTCACAGCTTGCGGGGAGTGGGCCTTCTCCTGGCCTTGTTCTTGCTCATAAACAGGTCACTTC
CTCCATGAAGAGACCAGTTTCCACGCTCCCATCTCTCACTGCTGACTCAGCGATGCCTCTGCCTCGGTCTGCTTTTGAAGACTGTGACCT
TCACCAGGAGGTTTTACTTACACCAGTCGGGAAGATTAGTCCCTCATTCTGCCTGGAGTGCCCCGTGTTTGACTTGGCAGCGGGTGTGGA
GCCATCCCCGCGTCCTCCTGGCGCATTGCCACTGTGGCTGTCCAGGAACAGGATGTGGCTGCCTTGGCCGAATGTTGTCCTACTCTCCCC
AACCCCGGCGCCTCAGCTCCTCAGCTCCTCGGGCCCCTGCGTCTGGCTGGTGTTTGCAGGGCTTTCGCTCTGCTCTGGTATTGCTCTGCC
TTTATAGAAAGTCTTATTGAAGAAGTGTAAGAAAGACCTAAGGTGGGGAAGACTCCTACACACACCATTAGTATCAGTGACACCAGCAAT
GTAGGTTCCCAGCCCCTTCCCAGTGGCAGCTTGTGTGTCCAGGAGATAGGACATCATTTAACGCATCAGCAAAGTAGCAGCAGATGCCAC
ATACAGAGTAGAGCGAAGGCATTTGGTGGATCGGTCACTAGAGATCTATCTTGCAGAAAGTATGTTTTTCCTCATAAAAGTGCCTCTTAA
TTGGCCATTGTACCAGCCACTTGTCCTAGCCAAATGTCCAAAACACGCCCTTGGGCCCCGCCACGTTACAATCCACAGATTGTCTGTCTG
AGTCGTTTAAGGCATTTCCTGGTGCTTGTGTTCCATGAATAAAAGGACAAAGTCAGAAGATCACTGATGTCTTACTGTCAACAGAGATAT
TTTAAAAGAGAGAAGCAGGAAAAGATCTTCCTTTTTTGATCTACAACTTATATAGTTTTCTGATTATGCACATAATAGATATGCCTTCCA
GATGCATAAGGCAAACATCTGGAAAGAAATATACCCAAATCTTAGCAGGGGTTATCTTTGGGAGTGGAGTACATGGGATTTTGCTTTCTT
CATTTTTATAATTTTATATTACTGTCTTGGAAGATGTGTTTATGTGTGTGTGTTACTTTTACAATCAGGAAAACATATTTAATAACATAT
AGTCAAGAAAACAGACTTAAAAATAAATACTATGTGTCCATTGAGAAAATTCACAATATAAACAGAAATACAAATAAATACATACACAAT
TTTAAAGTCACCTGTAGCCCTACCCTTAGAGGTACCCAGGGTTAACATTTTGGTGGTATTGTCTTATCAATTTTTCCGTTGATACATTCA
GCAAATTTGGAGCACATTGACCATGGAGTTTTGTGTCCAAATCCAATCTGAATTTACCTGGAAGAGGCCTTGACACCTGCATGGAAATGA
GCTAAGAAAACCACTGGAGCCTTGGGAGCTCTTTGGCCTCCTGGCTGGCCCAGTAATATCTGAGCTCCTTTGGTTAATTTATAACTGATA
TAAAACTACATCTTCTTTATAATATAAATTGTACCTGTGAGTCTAGAAGCTTTAAATGTGTTTAAATTAAAATATTCAAGCTAAATGTTA
CTGCTCTCTCCCAAATTCTGTAAGTTTGACTCCCGTTACCCCAATTAGAAGTAACTTCTTTGTTTCATGCCACTTTTATAGCATTTGGTA
ATTCTGCTATAACACATCTTGCCCCTATTATTAACTGTGCACAGCTACACAAAGGTGTGCCTTCTACGTGGGAACATGGATTGTGAATGA
CTCTGTAATGAGGCCTGAGTCTTAGTTATCTTTCCACTCACTCCCCGTCTCCCCTTTCCAACCCCAAAGGCTCACGATAGGGGCTCACTA
AATGTCAGTGTTTCACCAAAGTATTTTTTCCATTGTATTAAGAGTCCAGTCACTGTATATGGAAGTATTTTATTTTTTATTTTTTTATAT
CACTTGAGTCCACTAGTAGTACTTCCTTGCTCTGTTTGACTTGTCAGATACAAAGACACGGGATTAGATTTTGGGTGGTAAAATTGTGAT
ACGCATGGCTGTTGATGGAGTGGAACATCTTAGTGATGTGAGAAAGGTCATTTTAGTTATAAATGTAAACCAATTACTTTAGCACAACAA
TAAAGATGTTCTGGAAATTATTATAATTATTTTAGTTAATGGACTTGCCTGTAACAAGTGCTTATGTTTGGAATGTCCATTTTATTTTAT
TTTCCTCTACAATAAGGAATCCCTAAAGTTATGCCAACAAACTGGAATTGGATTGAGAAAGACAAAAGCAAGTGAGCAAGTGTATTAGAC
TAATTATCTCTAGTAGGGAATAAGCACTTAGAGCTAATTTTTTAATTTGGTTTATTTATTAGTAGCTCCCTGATTGTCTGTTAAGCCCCT
GGTTCCCACAGTTTGGTGTGGTCAGTCAACTTAAGCGACCTTTTAATGCAGAATCTTTACTTGGTTCTGAAGAGGAGGCAGTAGTTAAAA
TTGCTTCCTCTTAATGACTCTGAATGTATTGCCTGTGATTCCAAAGTTGTACATAATTGTTCAGACCTCCTCCATCCTTTTAAATTGCCT
GCTGCAGTAAATAACTAGTTTGAGTAGAACTAGATCCTGTCTATCTATTTGGCACATGTTCTGCTGCCTGGGGAGTAAGCAAGCTAAAGG
GATGAGAAAGACCACCTCCCCCTACCCTGGAAATTGCACTGCAAGGCAGGGCGAGAATGGGGTAGCTGGCAGACCTGGCCTCCTTGTTCC
CAGTCTTAGTTTTTCTTGAGAGATTCAGTATTCAGTAAAGAATAGCATTCAATTAGTCAAAAAATATATATATAACTTCTTCCTTTCCCT
TCCCATGAATCATTGCAGTCATTCCCTAAGTTTCTTCTCTTTTTTTTTCATGGCTGCTAGTATTTTATTTTAGAATCACAGACTCTCAGC
TTAGAGAGTCACAGTATCTCAATTATTTGCTCTGTTCAATACTTAACAATACCTCCTCACTCAATTCTACATAACTCCAGCTTAGTCTTC
CAAAATTCACTTTCATGATGCCACTCAGCATCTCAAATACCTTTCATTGGCTCTCTGCTGCCAAAGGATAAAGGTCAAAGTCATTAGCCT
CAACAGTGGGCTTCAACCAGCCTTTGGACCTCAGCCCCATTTATCCATCACAGAGGCTGGTAACTAGTCTCACTGCTCAGGCTGTGAGTG
TTCCTGATCTTGTGACATTCTGTGCTGTGCTTTTACATGGAACAGCTCTTTCCTCTCTCTTGGCCCATTCAGATCCTCCTCATCCAGCCC
CCATCTGAATCCTGTAACAGACACAACCACATCTACACAGTTTCCACATACCACTTGGAATTGCTGGTTATGCTGCAATGAGAGAATGTC
TTTGTCTTTAAATTGTAAGCTTCATGAGGGCAGGGACCATCTGTTTCTCTGTCTCTCCTCACAGTGCCTTGAGCAGTACGTTGTCTGGAA

>12223_12223_2_CAB39-RHBDD1_CAB39_chr2_231624830_ENST00000409788_RHBDD1_chr2_227860147_ENST00000341329_length(amino acids)=176AA_BP=1
MVRDETRRVVGYFWYFLFCFFIRNVLLFQNSHALLQILHNVCWRFVRLPKRERHDGSGRGLRCTPPVLPLLQSSSPKSHQAFKTLLSIPR

--------------------------------------------------------------
>12223_12223_3_CAB39-RHBDD1_CAB39_chr2_231624830_ENST00000410084_RHBDD1_chr2_227860147_ENST00000341329_length(transcript)=4197nt_BP=412nt
AGTCGGGCGGGCGGGGAAGTGCGGGCCGGGTCAACTGTCACCGGCTGCACCCGGGCTTCAGCGCCTCGCTCCCGCCCCTGGTAAACTTCC
TGTTGTCGGGAGGCAGATACCAGCTTTGTGACCAATTCAGGAAAATGCCTAACTGATTTCTGGTTAGGAATTGGGCGGTCGGAGCGTTCT
GGAGTTCAATGGAACCACCCCAAGCGCAGACTGCGTGCAGGCGCCGTAGTCGGCCCGCACCGGAGGGATTCAAAGGTAGCACAGGCGGAG
TGCAGCGGAGGCCCCTGCCGCTGCCGTCATGCCGTTCCCGTTTGGGAAGTCTCACAAATCTCCAGCAGACATTGTGAAGAATCTGAAGGA
GAGCATGGCTGTTCTGGAAAAGCAAGACATTTCTGATAAAAAAGCAGAAAAGGAAATACCAGAAATAGCCCACCACCCTACGGGTTTCAT
CTCTCACCAGAAGAAATGAGGAGACAGCGGCTTCACAGATTCGATAGCCAGTGAGGTGGCATCTTGGGAAGACATGGCCTATTCGTGTAA
TTATTGCCCATTTGGCTCATTCCCCAAGCCCCTAATTCATTTTAATTCATTTTAAACAAAAGCAGAGTACACCGGTATTGCTCCAGATCG
CTCACATCACCTGGGACAGTCCCATGGCCCCTATGAGTCAACTCACAGCTTGCGGGGAGTGGGCCTTCTCCTGGCCTTGTTCTTGCTCAT
AAACAGGTCACTTCCTCCATGAAGAGACCAGTTTCCACGCTCCCATCTCTCACTGCTGACTCAGCGATGCCTCTGCCTCGGTCTGCTTTT
GAAGACTGTGACCTTCACCAGGAGGTTTTACTTACACCAGTCGGGAAGATTAGTCCCTCATTCTGCCTGGAGTGCCCCGTGTTTGACTTG
GCAGCGGGTGTGGAGCCATCCCCGCGTCCTCCTGGCGCATTGCCACTGTGGCTGTCCAGGAACAGGATGTGGCTGCCTTGGCCGAATGTT
GTCCTACTCTCCCCAACCCCGGCGCCTCAGCTCCTCAGCTCCTCGGGCCCCTGCGTCTGGCTGGTGTTTGCAGGGCTTTCGCTCTGCTCT
GGTATTGCTCTGCCTTTATAGAAAGTCTTATTGAAGAAGTGTAAGAAAGACCTAAGGTGGGGAAGACTCCTACACACACCATTAGTATCA
GTGACACCAGCAATGTAGGTTCCCAGCCCCTTCCCAGTGGCAGCTTGTGTGTCCAGGAGATAGGACATCATTTAACGCATCAGCAAAGTA
GCAGCAGATGCCACATACAGAGTAGAGCGAAGGCATTTGGTGGATCGGTCACTAGAGATCTATCTTGCAGAAAGTATGTTTTTCCTCATA
AAAGTGCCTCTTAATTGGCCATTGTACCAGCCACTTGTCCTAGCCAAATGTCCAAAACACGCCCTTGGGCCCCGCCACGTTACAATCCAC
AGATTGTCTGTCTGAGTCGTTTAAGGCATTTCCTGGTGCTTGTGTTCCATGAATAAAAGGACAAAGTCAGAAGATCACTGATGTCTTACT
GTCAACAGAGATATTTTAAAAGAGAGAAGCAGGAAAAGATCTTCCTTTTTTGATCTACAACTTATATAGTTTTCTGATTATGCACATAAT
AGATATGCCTTCCAGATGCATAAGGCAAACATCTGGAAAGAAATATACCCAAATCTTAGCAGGGGTTATCTTTGGGAGTGGAGTACATGG
GATTTTGCTTTCTTCATTTTTATAATTTTATATTACTGTCTTGGAAGATGTGTTTATGTGTGTGTGTTACTTTTACAATCAGGAAAACAT
ATTTAATAACATATAGTCAAGAAAACAGACTTAAAAATAAATACTATGTGTCCATTGAGAAAATTCACAATATAAACAGAAATACAAATA
AATACATACACAATTTTAAAGTCACCTGTAGCCCTACCCTTAGAGGTACCCAGGGTTAACATTTTGGTGGTATTGTCTTATCAATTTTTC
CGTTGATACATTCAGCAAATTTGGAGCACATTGACCATGGAGTTTTGTGTCCAAATCCAATCTGAATTTACCTGGAAGAGGCCTTGACAC
CTGCATGGAAATGAGCTAAGAAAACCACTGGAGCCTTGGGAGCTCTTTGGCCTCCTGGCTGGCCCAGTAATATCTGAGCTCCTTTGGTTA
ATTTATAACTGATATAAAACTACATCTTCTTTATAATATAAATTGTACCTGTGAGTCTAGAAGCTTTAAATGTGTTTAAATTAAAATATT
CAAGCTAAATGTTACTGCTCTCTCCCAAATTCTGTAAGTTTGACTCCCGTTACCCCAATTAGAAGTAACTTCTTTGTTTCATGCCACTTT
TATAGCATTTGGTAATTCTGCTATAACACATCTTGCCCCTATTATTAACTGTGCACAGCTACACAAAGGTGTGCCTTCTACGTGGGAACA
TGGATTGTGAATGACTCTGTAATGAGGCCTGAGTCTTAGTTATCTTTCCACTCACTCCCCGTCTCCCCTTTCCAACCCCAAAGGCTCACG
ATAGGGGCTCACTAAATGTCAGTGTTTCACCAAAGTATTTTTTCCATTGTATTAAGAGTCCAGTCACTGTATATGGAAGTATTTTATTTT
TTATTTTTTTATATCACTTGAGTCCACTAGTAGTACTTCCTTGCTCTGTTTGACTTGTCAGATACAAAGACACGGGATTAGATTTTGGGT
GGTAAAATTGTGATACGCATGGCTGTTGATGGAGTGGAACATCTTAGTGATGTGAGAAAGGTCATTTTAGTTATAAATGTAAACCAATTA
CTTTAGCACAACAATAAAGATGTTCTGGAAATTATTATAATTATTTTAGTTAATGGACTTGCCTGTAACAAGTGCTTATGTTTGGAATGT
CCATTTTATTTTATTTTCCTCTACAATAAGGAATCCCTAAAGTTATGCCAACAAACTGGAATTGGATTGAGAAAGACAAAAGCAAGTGAG
CAAGTGTATTAGACTAATTATCTCTAGTAGGGAATAAGCACTTAGAGCTAATTTTTTAATTTGGTTTATTTATTAGTAGCTCCCTGATTG
TCTGTTAAGCCCCTGGTTCCCACAGTTTGGTGTGGTCAGTCAACTTAAGCGACCTTTTAATGCAGAATCTTTACTTGGTTCTGAAGAGGA
GGCAGTAGTTAAAATTGCTTCCTCTTAATGACTCTGAATGTATTGCCTGTGATTCCAAAGTTGTACATAATTGTTCAGACCTCCTCCATC
CTTTTAAATTGCCTGCTGCAGTAAATAACTAGTTTGAGTAGAACTAGATCCTGTCTATCTATTTGGCACATGTTCTGCTGCCTGGGGAGT
AAGCAAGCTAAAGGGATGAGAAAGACCACCTCCCCCTACCCTGGAAATTGCACTGCAAGGCAGGGCGAGAATGGGGTAGCTGGCAGACCT
GGCCTCCTTGTTCCCAGTCTTAGTTTTTCTTGAGAGATTCAGTATTCAGTAAAGAATAGCATTCAATTAGTCAAAAAATATATATATAAC
TTCTTCCTTTCCCTTCCCATGAATCATTGCAGTCATTCCCTAAGTTTCTTCTCTTTTTTTTTCATGGCTGCTAGTATTTTATTTTAGAAT
CACAGACTCTCAGCTTAGAGAGTCACAGTATCTCAATTATTTGCTCTGTTCAATACTTAACAATACCTCCTCACTCAATTCTACATAACT
CCAGCTTAGTCTTCCAAAATTCACTTTCATGATGCCACTCAGCATCTCAAATACCTTTCATTGGCTCTCTGCTGCCAAAGGATAAAGGTC
AAAGTCATTAGCCTCAACAGTGGGCTTCAACCAGCCTTTGGACCTCAGCCCCATTTATCCATCACAGAGGCTGGTAACTAGTCTCACTGC
TCAGGCTGTGAGTGTTCCTGATCTTGTGACATTCTGTGCTGTGCTTTTACATGGAACAGCTCTTTCCTCTCTCTTGGCCCATTCAGATCC
TCCTCATCCAGCCCCCATCTGAATCCTGTAACAGACACAACCACATCTACACAGTTTCCACATACCACTTGGAATTGCTGGTTATGCTGC
AATGAGAGAATGTCTTTGTCTTTAAATTGTAAGCTTCATGAGGGCAGGGACCATCTGTTTCTCTGTCTCTCCTCACAGTGCCTTGAGCAG

>12223_12223_3_CAB39-RHBDD1_CAB39_chr2_231624830_ENST00000410084_RHBDD1_chr2_227860147_ENST00000341329_length(amino acids)=120AA_BP=
MKRPVSTLPSLTADSAMPLPRSAFEDCDLHQEVLLTPVGKISPSFCLECPVFDLAAGVEPSPRPPGALPLWLSRNRMWLPWPNVVLLSPT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CAB39-RHBDD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CAB39-RHBDD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CAB39-RHBDD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource