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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARID4B-SOX5 (FusionGDB2 ID:HG51742TG6660)

Fusion Gene Summary for ARID4B-SOX5

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID4B-SOX5
Fusion gene ID: hg51742tg6660
HgeneTgene
Gene symbol

ARID4B

SOX5

Gene ID

51742

6660

Gene nameAT-rich interaction domain 4BSRY-box transcription factor 5
SynonymsBCAA|BRCAA1|RBBP1L1|RBP1L1|SAP180L-SOX5|L-SOX5B|L-SOX5F|LAMSHF
Cytomap('ARID4B')('SOX5')

1q42.3

12p12.1

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 4B180 kDa Sin3-associated polypeptideARID domain-containing protein 4BAT rich interactive domain 4B (RBP1-like)Rb-binding protein homologSIN3A-associated protein 180breast cancer-associated antigen 1bretranscription factor SOX-5SRY (sex determining region Y)-box 5SRY-box 5
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264183, ENST00000366603, 
ENST00000349213, ENST00000494543, 
Fusion gene scores* DoF score23 X 20 X 9=414016 X 19 X 9=2736
# samples 2918
** MAII scorelog2(29/4140*10)=-3.83550596237175
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/2736*10)=-3.92599941855622
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARID4B [Title/Abstract] AND SOX5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARID4B(235377084)-SOX5(24048958), # samples:2
Anticipated loss of major functional domain due to fusion event.ARID4B-SOX5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID4B-SOX5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID4B-SOX5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID4B-SOX5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSOX5

GO:0032332

positive regulation of chondrocyte differentiation

21401405

TgeneSOX5

GO:0061036

positive regulation of cartilage development

21401405

TgeneSOX5

GO:0071560

cellular response to transforming growth factor beta stimulus

21401405

TgeneSOX5

GO:2000741

positive regulation of mesenchymal stem cell differentiation

21401405


check buttonFusion gene breakpoints across ARID4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SOX5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-A5GH-01AARID4Bchr1

235377084

-SOX5chr12

24048958

-


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Fusion Gene ORF analysis for ARID4B-SOX5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000264183ENST00000309359ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-5UTRENST00000264183ENST00000381381ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-5UTRENST00000264183ENST00000451604ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-5UTRENST00000264183ENST00000537393ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-5UTRENST00000264183ENST00000541536ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-5UTRENST00000366603ENST00000309359ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-5UTRENST00000366603ENST00000381381ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-5UTRENST00000366603ENST00000451604ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-5UTRENST00000366603ENST00000537393ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-5UTRENST00000366603ENST00000541536ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-intronENST00000264183ENST00000396007ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-intronENST00000264183ENST00000441133ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-intronENST00000264183ENST00000536850ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-intronENST00000264183ENST00000541847ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-intronENST00000264183ENST00000545921ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-intronENST00000366603ENST00000396007ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-intronENST00000366603ENST00000441133ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-intronENST00000366603ENST00000536850ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-intronENST00000366603ENST00000541847ARID4Bchr1

235377084

-SOX5chr12

24048958

-
5CDS-intronENST00000366603ENST00000545921ARID4Bchr1

235377084

-SOX5chr12

24048958

-
In-frameENST00000264183ENST00000546136ARID4Bchr1

235377084

-SOX5chr12

24048958

-
In-frameENST00000366603ENST00000546136ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-3CDSENST00000349213ENST00000546136ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-3CDSENST00000494543ENST00000546136ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-5UTRENST00000349213ENST00000309359ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-5UTRENST00000349213ENST00000381381ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-5UTRENST00000349213ENST00000451604ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-5UTRENST00000349213ENST00000537393ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-5UTRENST00000349213ENST00000541536ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-5UTRENST00000494543ENST00000309359ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-5UTRENST00000494543ENST00000381381ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-5UTRENST00000494543ENST00000451604ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-5UTRENST00000494543ENST00000537393ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-5UTRENST00000494543ENST00000541536ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-intronENST00000349213ENST00000396007ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-intronENST00000349213ENST00000441133ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-intronENST00000349213ENST00000536850ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-intronENST00000349213ENST00000541847ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-intronENST00000349213ENST00000545921ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-intronENST00000494543ENST00000396007ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-intronENST00000494543ENST00000441133ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-intronENST00000494543ENST00000536850ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-intronENST00000494543ENST00000541847ARID4Bchr1

235377084

-SOX5chr12

24048958

-
intron-intronENST00000494543ENST00000545921ARID4Bchr1

235377084

-SOX5chr12

24048958

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000366603ARID4Bchr1235377084-ENST00000546136SOX5chr1224048958-9187221822004473757
ENST00000264183ARID4Bchr1235377084-ENST00000546136SOX5chr1224048958-9308233923214594757

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366603ENST00000546136ARID4Bchr1235377084-SOX5chr1224048958-0.0003564480.99964356
ENST00000264183ENST00000546136ARID4Bchr1235377084-SOX5chr1224048958-0.0004424140.99955755

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Fusion Genomic Features for ARID4B-SOX5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARID4B-SOX5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:235377084/chr12:24048958)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID4Bchr1:235377084chr12:24048958ENST00000264183-1724154_1596131313.0Compositional biasNote=Poly-Ser
HgeneARID4Bchr1:235377084chr12:24048958ENST00000264183-1724268_5676131313.0Compositional biasNote=Glu-rich
HgeneARID4Bchr1:235377084chr12:24048958ENST00000366603-1724154_1596131313.0Compositional biasNote=Poly-Ser
HgeneARID4Bchr1:235377084chr12:24048958ENST00000366603-1724268_5676131313.0Compositional biasNote=Glu-rich
HgeneARID4Bchr1:235377084chr12:24048958ENST00000264183-1724306_3986131313.0DomainARID
HgeneARID4Bchr1:235377084chr12:24048958ENST00000366603-1724306_3986131313.0DomainARID
HgeneARID4Bchr1:235377084chr12:24048958ENST00000264183-1724465_4736131313.0RegionNote=Antigenic epitope
HgeneARID4Bchr1:235377084chr12:24048958ENST00000366603-1724465_4736131313.0RegionNote=Antigenic epitope
TgeneSOX5chr1:235377084chr12:24048958ENST00000309359015193_2740751.0Coiled coilOntology_term=ECO:0000255
TgeneSOX5chr1:235377084chr12:24048958ENST00000309359015448_5150751.0Coiled coilOntology_term=ECO:0000255
TgeneSOX5chr1:235377084chr12:24048958ENST00000381381013193_2740643.0Coiled coilOntology_term=ECO:0000255
TgeneSOX5chr1:235377084chr12:24048958ENST00000381381013448_5150643.0Coiled coilOntology_term=ECO:0000255
TgeneSOX5chr1:235377084chr12:24048958ENST0000039600707193_2740378.0Coiled coilOntology_term=ECO:0000255
TgeneSOX5chr1:235377084chr12:24048958ENST0000039600707448_5150378.0Coiled coilOntology_term=ECO:0000255
TgeneSOX5chr1:235377084chr12:24048958ENST00000451604015193_27412764.0Coiled coilOntology_term=ECO:0000255
TgeneSOX5chr1:235377084chr12:24048958ENST00000451604015448_51512764.0Coiled coilOntology_term=ECO:0000255
TgeneSOX5chr1:235377084chr12:24048958ENST00000541536-112193_27477643.0Coiled coilOntology_term=ECO:0000255
TgeneSOX5chr1:235377084chr12:24048958ENST00000541536-112448_51577643.0Coiled coilOntology_term=ECO:0000255
TgeneSOX5chr1:235377084chr12:24048958ENST00000545921015193_2742754.0Coiled coilOntology_term=ECO:0000255
TgeneSOX5chr1:235377084chr12:24048958ENST00000545921015448_5152754.0Coiled coilOntology_term=ECO:0000255
TgeneSOX5chr1:235377084chr12:24048958ENST00000546136-114193_27477751.0Coiled coilOntology_term=ECO:0000255
TgeneSOX5chr1:235377084chr12:24048958ENST00000546136-114448_51577751.0Coiled coilOntology_term=ECO:0000255
TgeneSOX5chr1:235377084chr12:24048958ENST00000309359015556_6240751.0DNA bindingHMG box
TgeneSOX5chr1:235377084chr12:24048958ENST00000381381013556_6240643.0DNA bindingHMG box
TgeneSOX5chr1:235377084chr12:24048958ENST0000039600707556_6240378.0DNA bindingHMG box
TgeneSOX5chr1:235377084chr12:24048958ENST00000451604015556_62412764.0DNA bindingHMG box
TgeneSOX5chr1:235377084chr12:24048958ENST00000541536-112556_62477643.0DNA bindingHMG box
TgeneSOX5chr1:235377084chr12:24048958ENST00000545921015556_6242754.0DNA bindingHMG box
TgeneSOX5chr1:235377084chr12:24048958ENST00000546136-114556_62477751.0DNA bindingHMG box

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID4Bchr1:235377084chr12:24048958ENST00000264183-17241231_12706131313.0Coiled coilOntology_term=ECO:0000255
HgeneARID4Bchr1:235377084chr12:24048958ENST00000264183-1724728_7546131313.0Coiled coilOntology_term=ECO:0000255
HgeneARID4Bchr1:235377084chr12:24048958ENST00000349213-1231231_127001227.0Coiled coilOntology_term=ECO:0000255
HgeneARID4Bchr1:235377084chr12:24048958ENST00000349213-123728_75401227.0Coiled coilOntology_term=ECO:0000255
HgeneARID4Bchr1:235377084chr12:24048958ENST00000366603-17241231_12706131313.0Coiled coilOntology_term=ECO:0000255
HgeneARID4Bchr1:235377084chr12:24048958ENST00000366603-1724728_7546131313.0Coiled coilOntology_term=ECO:0000255
HgeneARID4Bchr1:235377084chr12:24048958ENST00000264183-17241095_11016131313.0Compositional biasNote=Poly-Ser
HgeneARID4Bchr1:235377084chr12:24048958ENST00000264183-17241271_13036131313.0Compositional biasNote=Ser-rich
HgeneARID4Bchr1:235377084chr12:24048958ENST00000349213-1231095_110101227.0Compositional biasNote=Poly-Ser
HgeneARID4Bchr1:235377084chr12:24048958ENST00000349213-1231271_130301227.0Compositional biasNote=Ser-rich
HgeneARID4Bchr1:235377084chr12:24048958ENST00000349213-123154_15901227.0Compositional biasNote=Poly-Ser
HgeneARID4Bchr1:235377084chr12:24048958ENST00000349213-123268_56701227.0Compositional biasNote=Glu-rich
HgeneARID4Bchr1:235377084chr12:24048958ENST00000366603-17241095_11016131313.0Compositional biasNote=Poly-Ser
HgeneARID4Bchr1:235377084chr12:24048958ENST00000366603-17241271_13036131313.0Compositional biasNote=Ser-rich
HgeneARID4Bchr1:235377084chr12:24048958ENST00000349213-123306_39801227.0DomainARID
HgeneARID4Bchr1:235377084chr12:24048958ENST00000264183-17241130_11376131313.0RegionNote=Antigenic epitope
HgeneARID4Bchr1:235377084chr12:24048958ENST00000349213-1231130_113701227.0RegionNote=Antigenic epitope
HgeneARID4Bchr1:235377084chr12:24048958ENST00000349213-123465_47301227.0RegionNote=Antigenic epitope
HgeneARID4Bchr1:235377084chr12:24048958ENST00000366603-17241130_11376131313.0RegionNote=Antigenic epitope


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Fusion Gene Sequence for ARID4B-SOX5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6488_6488_1_ARID4B-SOX5_ARID4B_chr1_235377084_ENST00000264183_SOX5_chr12_24048958_ENST00000546136_length(transcript)=9308nt_BP=2339nt
AAAGGGGGGGAACCTAGAGTCGGTGGGGGGGAAGCGATGTTTGCCCGTCAGTCGAGTCCGGAGTGAGGAGCTCGGTCGCCGAAGCGGAGG
GAGACTCTTGAGCTTCATCTTGCCGCCGCCACGGCCACCGCCTGGACCTTTGCCCGGAGGGAGCTGCAGAGGGTCCATCGCCGCCGTCCT
CTGGAGGGCAGCGCGATTGGGGGCCCGGACCTCCAGTCCGGGGGGGATTTTTCGTCGTCCCCCTCCCCCCAACCAGGGAGCCCGAGCGGC
CGCCAAACAAAGGTACCAGTCGCCGCCGCGGGAGGAGGAGGAGCCGGAGCCTCTGCCTCAGCAGCCGCTGGACCCGCCGCCCTTCTTCCC
CATCTCTCCCCCGGGCCTGCTGGTTTTGGGGGGGAGAAGGAGAGAGGGGACTCTGGACGTGCCAGGGTCAGATCTCGCCTCCGAGGAAGG
TGCAGCTGAACCTGGTGTTTTAGAGGATACCTTGGTCCCAGAGTCATCATGAAGGCCCTTGATGAGCCTCCCTATTTGACAGTGGGCACT
GATGTGAGTGCTAAATACAGAGGAGCCTTTTGTGAAGCCAAGATCAAGACAGCAAAAAGACTTGTCAAAGTCAAGGTGACATTTAGACAT
GATTCTTCAACAGTGGAAGTTCAGGATGACCACATAAAGGGCCCACTAAAGGTAGGAGCTATTGTGGAAGTGAAGAATCTTGATGGTGCA
TATCAGGAAGCTGTTATCAATAAACTAACAGATGCGAGTTGGTACACTGTAGTTTTTGATGACGGAGATGAGAAGACACTGAGACGATCT
TCACTGTGCCTGAAAGGAGAGAGGCATTTTGCTGAAAGTGAAACATTAGACCAGCTCCCACTCACCAACCCTGAGCATTTTGGCACTCCA
GTCATAGGAAAGAAAACAAATAGAGGAAGAAGATCTAATCATATACCAGAGGAAGAGTCTTCATCATCCTCCAGTGATGAAGATGAGGAT
GATAGGAAACAGATTGATGAGCTACTAGGCAAAGTTGTATGTGTAGATTACATTAGTTTGGATAAAAAGAAAGCACTGTGGTTTCCTGCA
TTGGTGGTTTGTCCTGATTGTAGTGATGAGATTGCTGTAAAAAAGGACAATATTCTTGTTCGATCTTTCAAAGATGGAAAATTTACTTCA
GTTCCAAGAAAAGATGTCCATGAAATTACTAGTGACACTGCACCAAAGCCTGATGCTGTTTTAAAGCAAGCCTTTGAACAGGCACTTGAA
TTTCACAAAAGTAGAACTATTCCTGCTAACTGGAAGACTGAATTGAAAGAAGATAGCTCTAGCAGTGAAGCAGAGGAAGAAGAGGAGGAG
GAAGATGATGAAAAAGAAAAGGAGGATAATAGCAGTGAAGAAGAAGAAGAAATAGAACCATTTCCAGAAGAAAGGGAGAACTTTCTTCAG
CAATTGTACAAATTTATGGAAGATAGAGGTACACCTATTAACAAACGACCTGTACTTGGATATCGAAATTTGAATCTCTTTAAGTTATTC
AGACTTGTACACAAACTTGGAGGATTTGATAATATTGAAAGTGGAGCTGTTTGGAAACAAGTCTACCAAGATCTTGGAATCCCTGTCTTA
AATTCAGCTGCAGGATACAATGTTAAATGTGCTTATAAAAAATACTTATATGGTTTTGAGGAGTACTGTAGATCAGCCAACATTGAATTT
CAGATGGCATTGCCAGAGAAAGTTGTTAACAAGCAATGTAAGGAGTGTGAAAATGTAAAAGAAATAAAAGTTAAGGAGGAAAATGAAACA
GAGATCAAAGAAATAAAGATGGAGGAGGAGAGGAATATAATACCAAGAGAAGAAAAGCCTATTGAGGATGAAATTGAAAGAAAAGAAAAT
ATTAAGCCCTCTCTGGGAAGTAAAAAGAATTTATTAGAATCTATACCTACACATTCTGATCAGGAAAAAGAAGTTAACATTAAAAAACCA
GAAGACAATGAAAATCTGGATGACAAAGATGATGACACAACTAGGGTAGATGAATCCCTCAACATAAAGGTAGAAGCTGAGGAAGAAAAA
GCAAAATCTGGAGATGAAACGAATAAAGAAGAAGATGAAGATGATGAAGAAGCAGAAGAGGAGGAGGAGGAGGAAGAAGAAGAAGAGGAT
GAAGATGATGATGACAACAATGAGGAAGAGGAGTTTGAGTGCTATCCACCAGGCATGAAAGTCCAAGTGCGGTATGGACGAGGGAAAAAT
CAAAAAATGTATGAAGCTAGTATTAAAGATTCTGATGTCGAAGGTGGAGAGGTCCTTTACTTGGTGCATTACTGCGGATGGAATGTGAGA
GGATGTCTTCCAAGCGACCAGCCTCTCCGTATGGGGAAGCAGATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGAGG
AGAGTGACGGGCTCCCAGCCTTTCACCTTCCCTTGCATGTGAGTTTTCCCAACAAGCCTCACTCTGAGGAATTTCAGCCAGTTTCTCTGC
TGACGCAAGAGACTTGTGGCCATAGGACTCCCACTTCTCAGCACAATACAATGGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGCCC
CACACAACTCATCTACCTCACCTCAGAAGGCAGAAGAAGGTGGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCCTG
AACGGCGCAAGGGCAGTTTAGCTGATGTTGTTGACACCTTGAAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAACCC
CCAGTATTGAAAAACTACTCTCAAAGGACTGGAAAGACAAGCTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCCCG
AGAGCTTAGCTGAGAAAGAAAGGCAACTCATGGGTATGATCAACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGAGC
AGAAGAAACTAGCTGCCTCTCAGATTGAGAAACAGCGTCAGCAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCAGC
AGCAGCTTCTACAGCAACAACACAAAATCAATTTGCTCCAGCAACAGATCCAGGTTCAAGGTCAGCTGCCGCCATTAATGATTCCCGTAT
TCCCTCCTGATCAACGGACACTGGCTGCAGCTGCCCAGCAAGGATTCCTCCTCCCTCCAGGCTTCAGCTATAAGGCTGGATGTAGTGACC
CTTACCCTGTTCAGCTGATCCCAACTACCATGGCAGCTGCTGCCGCAGCAACACCAGGCTTAGGCCCACTCCAACTGCAGCAGTTATATG
CTGCCCAGCTAGCTGCAATGCAGGTATCTCCAGGAGGGAAGCTGCCAGGCATACCCCAAGGCAACCTTGGTGCTGCTGTATCTCCTACCA
GCATTCACACAGACAAGAGCACAAACAGCCCACCACCCAAAAGCAAGGATGAAGTGGCACAGCCACTGAACCTATCAGCTAAACCCAAGA
CCTCTGATGGCAAATCACCCACATCACCCACCTCTCCCCATATGCCAGCTCTGAGAATAAACAGTGGGGCAGGCCCCCTCAAAGCCTCTG
TCCCAGCAGCGTTAGCTAGTCCTTCAGCCAGAGTTAGCACAATAGGTTACTTAAATGACCATGATGCTGTCACCAAGGCAATCCAAGAAG
CTCGGCAAATGAAGGAGCAACTCCGACGGGAACAACAGGTGCTTGATGGGAAGGTGGCTGTTGTGAATAGTCTGGGTCTCAATAACTGCC
GAACAGAAAAGGAAAAAACAACACTGGAGAGTCTGACTCAGCAACTGGCAGTTAAACAGAATGAAGAAGGAAAATTTAGCCATGCAATGA
TGGATTTCAATCTGAGTGGAGATTCTGATGGAAGTGCTGGAGTCTCAGAGTCAAGAATTTATAGGGAATCCCGAGGGCGTGGTAGCAATG
AACCCCACATAAAGCGTCCAATGAATGCCTTCATGGTGTGGGCTAAAGATGAACGGAGAAAGATCCTTCAAGCCTTTCCTGACATGCACA
ACTCCAACATCAGCAAGATATTGGGATCTCGCTGGAAAGCTATGACAAACCTAGAGAAACAGCCATATTATGAGGAGCAAGCCCGTCTCA
GCAAGCAGCACCTGGAGAAGTACCCTGACTATAAGTACAAGCCCAGGCCAAAGCGCACCTGCCTGGTGGATGGCAAAAAGCTGCGCATTG
GTGAATACAAGGCAATCATGCGCAACAGGCGGCAGGAAATGCGGCAGTACTTCAATGTTGGGCAACAAGCACAGATCCCCATTGCCACTG
CTGGTGTTGTGTACCCTGGAGCCATCGCCATGGCTGGGATGCCCTCCCCTCACCTGCCCTCGGAGCACTCAAGCGTGTCTAGCAGCCCAG
AGCCTGGGATGCCTGTTATCCAGAGCACTTACGGTGTGAAAGGAGAGGAGCCACATATCAAAGAAGAGATACAGGCCGAGGACATCAATG
GAGAAATTTATGATGAGTACGACGAGGAAGAGGATGATCCAGATGTAGATTATGGGAGTGACAGTGAAAACCATATTGCAGGACAAGCCA
ACTGATAAGGGTCAAAAGATTGTTGTGACCTTAGGACTTAAAGAAGCCCTAACTGGTTCATCCTTACCAGTGGCCAAGCACATTAACTTT
CTCATACACTGACTGTTACTTTAACTGTTAGTCTTAAATAGTTGGGACATCAGCTGACTAATAGACCTCAGCCTCAAAAGGCTTGGAAAG
AAAAAACAAATACAACAAGCAAACAACAATATCAACAACAAGAGATTGAAATAAGCTATGGGTAAAATAATGCCAGTAATTCAGCTGCTA
CATCCAAGCACTGAAGTCTTACCCGTCAACTTTTTTTTTTTTTTAAATAAACTTTATGGCTGTTTGTTCTACAATGTTCTAGAAATTCTC
ACTCAGGTACACAGTGCCAACAAGTGGCTTGTGAATGTGTTTTGTTGTTTTGTGCTACAATTTTTAAAAAGAAAAAAGTTTTGTTTTGTT
TTTTGGGGTTTCTGGGTTTTTTCCTTTTCTTTTTCTTTCCTTTCATTTTTTTTCTTTGTAATGCACCTGACAGAAAAAAAAGAAAAATGA
ATTTCTCTTTACTTCTCTCCACCTTCTCCATCTCTCTACTTTAAAGATGGAAGTCTGTGCATGAGGGGAAAGAGGGAAAAAGAGCCTGTT
TTTAACTTCCTTGCTATCCACCACAAAATAAGCAATTATTTTCTTTAGAGGACTTTATCTATTGCACACCACACTACATCTTTGAGCAAG
TGCCAAATTTGTACTGAAGTGTTGACCAAGTTCATTTTTTCTCTTTACTTTTTCCTTTTCCTTCTTAAGTTAGGACAGTGTTAAATCTTA
GACAATCCCTTGAAAAACCTGAAATACCAGCAGCTGGTGAGATTTGACTTTTTTTTTTAATGGAAACTGTAGGTGCTGTTCTCAGGTGAA
AAGAGAGAGAGAGAGAGAGACATAAGAAATTTAGAGAAAAATATTTTCTGATCTTGGATTTTTGTGTGTATGTATGTATGTGATTATGGT
ACTAATAATAGGAATAACGTTGGACCATTGTGAGTTAAACCCACATCTGGGGATGAAATCCCACATCCTCCCAAGTGACTGGTCTAGAAA
TAATCTTGACCTTGACTTTGCACTTCAAATGACAACTTAACCAAGTATAGGGCTCAGAAATTATATTTTTAAATGTCTGATTATTATTGG
ATGGATCAGGTGGCCCTGTGTAATAGAGGTGTGCATGTATAACATGGAAGCTACTAGCAAACTGCTCCCAGATGTCCTTTCTCCCTGGTC
AGTTGGTTCCATTAACGTTTGCTACTTAGTGATTTTTGTTTTTCCTGTTGATATTTTGAGCAAAACAATCATTGTTTTCATTGAATATAT
TTGGCCATTTTTTCAGACAAATAGAATTAGCTTATTTCTTCAACATTCCATCCTTTCCCGATCAGGAAATGAAACTGATGATTTTATAAG
GTATTTTTCACCCCTCCATGAAGTGAGGTGGAGGCCTTTAGCATTTCAGAAGTGTGGGCCATATGTAGTTCATGCCATAAAAAGTAGGAT
TTAATTAAAAGTCATTGCAGCCCAATAAAATGGAGCCTGGCTGCACCCAGGGATCCTTGCCACTGCTCTTCCCTTGCTGTCAGATTAATC
CACTGAAGTCCAACTTTGGTTCAAGCAGAGTATTTGCAAAGAGCAACAACTGAATGTGATGGGACTGCTTATGTAGATTTTGCCAGCCAA
ATGCCAAGGCAGTTGTAGGGCCTGTACAAATAAATGCAAAATCATTTCAAGTCAATTGCCATTATTTGTATTGAAGTATCAGATAGATAG
TAAATACTGCAACTAGTAGCTTGATGTGCTATAGTTTTCACTCCAGTCATCATTTTCCTATCTCACCCCCCGAAACACCACCCTAAAGTT
GGATTTTTACATATAAATAAAAAAAGAATCCCTTTTATTTTTCTCTCTCTCAGAAGACTTGCTCTGGGGTTTTGCTTGGAGGAGCTGATC
ATATCCTGCATGTCAGAGATTTCATTTTGTTTGTTTTTCTGTTTGTTTGTTTTTGATGACTTTATTTACATTTGAACTGCCTCTTTTTGC
TAGTGTTGTAATGATGATGATGATAAAATAATAATAATAATAGTAATAATAATAATAATGGTCAGCTGTTCCCAGATTAGTAAGTTATGT
ATAATTTATTTTATTTCTCCCTTTCTATTTTATTCTGCTCTGATTTGGAAGTGCAGCCAATAAGCTGTTAGATATTTAAAACAAATTTCC
ATCTCCAACTCATATATGTATGTATATGTATATATATATATACATATATATACACACATATACACACACACACACACATTTACCCACAAT
TTTACTTCTCTTTCCGTAAGTTTTCTCTTTTTTAAGAATTTTGGCCCCAACAATATCAGTTCTGATGTTTAAAACAAAGGAGTGAATTAA
TAGGAGGGTCGTGTTCAATCTTAATTAACTTATGCTCTCATCACTCATTTTAGTTATTTAATTGCCACAGTCATCTAGAGCCAATTTTTT
TTTGTTTTTGTTTGTTTTGTTTTTAAGCACTCTGGATAAGGAAAAAATAGACACTTGTTTTTATATCATTTTTATGTACAATGTGAAAAC
AGATTTTTAAAAAATTTGTTCTCTGTCTTTGTTAACAAATTCCTTCCGATTTATGTGGGTTCACCTCTCACGTTTGCTGGATACTTACTT
TACACCATGTTATGAAAGATGCTTTGTTTTCATTTCATGAGTTTGGGCTACAAGAATACTTTGTTTTAGCTCCAGGTAGATGCCATTGAA
GGCATTCATGGCTGAAATCAATTCTAACACACTTACCGATGAATTGACAACACTTTGGTGTTTGGTCTTTTTTTTGTTATATTTTGTTTT
ATTTGAAGGGGAAAACAAAATTGTTAATGGTGACTTTTAACTGCTGAAATTCAAAATTTGATTTTAGTTAGGTTTATGTCCGAGACTAAA
CTGTGCATGAACCGAAACAAAAAGCAAGTTCATACCGCTGCATTCTGTTCTCTTGTTCTGACGGTTAATTCACTGGACATCAAATTTTCT
TTGCCCTAGTTTTCCCCAAAAGAAAACAAAAGCAAAAATAGTTATATTAATGTTGAAAGTGCTTTGAAGTCACTTGATAAAAGGTGCTAT
GAATAGCAACTTACTGTGTTACTACATTGCCTTTTTGGCATTGGTTGATTTATAATTTTGGTAAAGGATCCTAAAACCCTGTATTCTTTT
TCTGTGCCCCATAATGACCAAAAAAGATAAAGAAAATGAGAGTAAGATCAAAAGATCAAACTAAAACATAAACAGTCTCCTTCCTGTCTG
CTTTCTTACCTATCTGTTCACACTTTATCTCTTTCCCTTTCTCTCTCTCTCTCACATGCGCGCGCGCGCGCGCGCACACACACACACACA
CACACTTGCCCCAACACTGAGAAATAATCTTGCCAGAATTCTGGTTTTTATAGTTGTTGTAGTCCGTTTCTCTAAAAATAGTCCTGTTTT
CATATGAATCTAAGAGAACATTACCGGAGAAAATAAAGTTACTCATTTATAGTTACTAATAATAAGTTAGTGATTAACTTACCACAATTG
GATAAAATATAAAACTATTCTTCAGCACATTTATACCTAAATTAGTGAAGTCCATTTGTGAAGTTCATTTGGCATCTGCAGTTAAGAGTT
AACCATGTATAAAATCCCTCCCAAAGAACATAATCATCGTTAGAACCAAATCCTCTTATAAAGAACAAATATAAAAAAGTTTTCTGTGGT
GAAGCTATTTTATAGATTTGATTTCCGGAGTAGAATTTTACCTTAATTCACTTAAAGAAAATTAACCATTTTTTGGTCCAACTTCAGATA
TTTTCTTAATCCAGAAGCTGTGACTGTTCCCAGAAGAAACCTCTTATATCACATTTAAAACATAAAAAATAATTACACTTTCACTCATTC
TAATGGGTAAATTGTTGAATTGTAATAAACAACTGTATATTTACAAACAGGTTTATAAGGTATTTGTCTATCAAATTAATAATAAAATAA
AACTTACGGGGTCTGCAAGGAAAACTATGAAGGCCACTTAAAGTGGTTCAGGTATCCCTTTGTCTTGTAGGGCATAGCTGTTGGTTTAGC
CAGGCTTTTACAGTATTTAATTTTAAAGTATCCTATAACTATCAACTTCCCAGGTTGAAGACGATGTGTTGAGTTTCCTACTGATTGATT
GATTCCTGTCCTCCCCAGTGTTTCCGTCACTGGTTCACTAAAACAGTATTTATATAGCTCCACTGGCTCTAAAGCTCTTAGTCCTTCTAA
TATTTTGGATTTTACAAGTAAAAATGGAAAAAAAATAGAAAAGAGACAATCAAATGCCTGGAGCTTAAAACAAAGTATGTGCAACCTACC
ATCTCACTTGAAATTTAATAAAATAATAAGTAATTATGTAAATATAACATAGAGTTATAGATTTATATTTTGTTCATAACACATAGTGTA
ATATAAGTTGTATATTTTCATGTTTTTGGTTTTATGTTATCATTCATGCCACAATAAAAATAAAACAGGAGTTTATGTGCTCTTAAAAAA
AAGATGTGGGTTGCCACCAACCTGTTTTTCGTTTTTGTTTTTTGTTTATTTTATTTTATTTTTTTGCATTCTCCTTTTTCAGTATTACTG

>6488_6488_1_ARID4B-SOX5_ARID4B_chr1_235377084_ENST00000264183_SOX5_chr12_24048958_ENST00000546136_length(amino acids)=757AA_BP=6
MRMECERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNK
VMSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFG
EIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLP
PLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLG
AAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPAALASPSARVSTIGYLNDHDAV
TKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSESRIYRES
RGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVD
GKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEI

--------------------------------------------------------------
>6488_6488_2_ARID4B-SOX5_ARID4B_chr1_235377084_ENST00000366603_SOX5_chr12_24048958_ENST00000546136_length(transcript)=9187nt_BP=2218nt
GGCGGGGCCAGATGTTGATCTCGCTCCCACTTGTCGGGTCTGAGCCCGGAACGGGACGTGGGCAGGGGCTCTGTGGCGGGCCGGTCCTGC
CCGCGGCCCACAGGCCCTCCTGGCCCCTCGGTGGCCCCCGGCCGGCCTCTCGCTCGGACGCGGCGCGTGGGGGCGCGGATTCGCTCGGCC
GGGCGCCGAGGCCCTAGGGGAGAGCGGCCGGCCCTGCGCCGGACGCCGGGCTTGTTGTGAGTTTCTTCTCTGACAGAAATGGCGTCATTG
TCGTAGACGGGAAACTCCGTCGGGTCTCGACAATGGGGACGGGAAGCTGCCGAGCTGTGTGCAGCTGAACCTGGTGTTTTAGAGGATACC
TTGGTCCCAGAGTCATCATGAAGGCCCTTGATGAGCCTCCCTATTTGACAGTGGGCACTGATGTGAGTGCTAAATACAGAGGAGCCTTTT
GTGAAGCCAAGATCAAGACAGCAAAAAGACTTGTCAAAGTCAAGGTGACATTTAGACATGATTCTTCAACAGTGGAAGTTCAGGATGACC
ACATAAAGGGCCCACTAAAGGTAGGAGCTATTGTGGAAGTGAAGAATCTTGATGGTGCATATCAGGAAGCTGTTATCAATAAACTAACAG
ATGCGAGTTGGTACACTGTAGTTTTTGATGACGGAGATGAGAAGACACTGAGACGATCTTCACTGTGCCTGAAAGGAGAGAGGCATTTTG
CTGAAAGTGAAACATTAGACCAGCTCCCACTCACCAACCCTGAGCATTTTGGCACTCCAGTCATAGGAAAGAAAACAAATAGAGGAAGAA
GATCTAATCATATACCAGAGGAAGAGTCTTCATCATCCTCCAGTGATGAAGATGAGGATGATAGGAAACAGATTGATGAGCTACTAGGCA
AAGTTGTATGTGTAGATTACATTAGTTTGGATAAAAAGAAAGCACTGTGGTTTCCTGCATTGGTGGTTTGTCCTGATTGTAGTGATGAGA
TTGCTGTAAAAAAGGACAATATTCTTGTTCGATCTTTCAAAGATGGAAAATTTACTTCAGTTCCAAGAAAAGATGTCCATGAAATTACTA
GTGACACTGCACCAAAGCCTGATGCTGTTTTAAAGCAAGCCTTTGAACAGGCACTTGAATTTCACAAAAGTAGAACTATTCCTGCTAACT
GGAAGACTGAATTGAAAGAAGATAGCTCTAGCAGTGAAGCAGAGGAAGAAGAGGAGGAGGAAGATGATGAAAAAGAAAAGGAGGATAATA
GCAGTGAAGAAGAAGAAGAAATAGAACCATTTCCAGAAGAAAGGGAGAACTTTCTTCAGCAATTGTACAAATTTATGGAAGATAGAGGTA
CACCTATTAACAAACGACCTGTACTTGGATATCGAAATTTGAATCTCTTTAAGTTATTCAGACTTGTACACAAACTTGGAGGATTTGATA
ATATTGAAAGTGGAGCTGTTTGGAAACAAGTCTACCAAGATCTTGGAATCCCTGTCTTAAATTCAGCTGCAGGATACAATGTTAAATGTG
CTTATAAAAAATACTTATATGGTTTTGAGGAGTACTGTAGATCAGCCAACATTGAATTTCAGATGGCATTGCCAGAGAAAGTTGTTAACA
AGCAATGTAAGGAGTGTGAAAATGTAAAAGAAATAAAAGTTAAGGAGGAAAATGAAACAGAGATCAAAGAAATAAAGATGGAGGAGGAGA
GGAATATAATACCAAGAGAAGAAAAGCCTATTGAGGATGAAATTGAAAGAAAAGAAAATATTAAGCCCTCTCTGGGAAGTAAAAAGAATT
TATTAGAATCTATACCTACACATTCTGATCAGGAAAAAGAAGTTAACATTAAAAAACCAGAAGACAATGAAAATCTGGATGACAAAGATG
ATGACACAACTAGGGTAGATGAATCCCTCAACATAAAGGTAGAAGCTGAGGAAGAAAAAGCAAAATCTGGAGATGAAACGAATAAAGAAG
AAGATGAAGATGATGAAGAAGCAGAAGAGGAGGAGGAGGAGGAAGAAGAAGAAGAGGATGAAGATGATGATGACAACAATGAGGAAGAGG
AGTTTGAGTGCTATCCACCAGGCATGAAAGTCCAAGTGCGGTATGGACGAGGGAAAAATCAAAAAATGTATGAAGCTAGTATTAAAGATT
CTGATGTCGAAGGTGGAGAGGTCCTTTACTTGGTGCATTACTGCGGATGGAATGTGAGAGGATGTCTTCCAAGCGACCAGCCTCTCCGTA
TGGGGAAGCAGATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGAGGAGAGTGACGGGCTCCCAGCCTTTCACCTTCC
CTTGCATGTGAGTTTTCCCAACAAGCCTCACTCTGAGGAATTTCAGCCAGTTTCTCTGCTGACGCAAGAGACTTGTGGCCATAGGACTCC
CACTTCTCAGCACAATACAATGGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGCCCCACACAACTCATCTACCTCACCTCAGAAGGC
AGAAGAAGGTGGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCCTGAACGGCGCAAGGGCAGTTTAGCTGATGTTGT
TGACACCTTGAAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAACCCCCAGTATTGAAAAACTACTCTCAAAGGACTG
GAAAGACAAGCTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCCCGAGAGCTTAGCTGAGAAAGAAAGGCAACTCAT
GGGTATGATCAACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGAGCAGAAGAAACTAGCTGCCTCTCAGATTGAGAA
ACAGCGTCAGCAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCAGCAGCAGCTTCTACAGCAACAACACAAAATCAA
TTTGCTCCAGCAACAGATCCAGGTTCAAGGTCAGCTGCCGCCATTAATGATTCCCGTATTCCCTCCTGATCAACGGACACTGGCTGCAGC
TGCCCAGCAAGGATTCCTCCTCCCTCCAGGCTTCAGCTATAAGGCTGGATGTAGTGACCCTTACCCTGTTCAGCTGATCCCAACTACCAT
GGCAGCTGCTGCCGCAGCAACACCAGGCTTAGGCCCACTCCAACTGCAGCAGTTATATGCTGCCCAGCTAGCTGCAATGCAGGTATCTCC
AGGAGGGAAGCTGCCAGGCATACCCCAAGGCAACCTTGGTGCTGCTGTATCTCCTACCAGCATTCACACAGACAAGAGCACAAACAGCCC
ACCACCCAAAAGCAAGGATGAAGTGGCACAGCCACTGAACCTATCAGCTAAACCCAAGACCTCTGATGGCAAATCACCCACATCACCCAC
CTCTCCCCATATGCCAGCTCTGAGAATAAACAGTGGGGCAGGCCCCCTCAAAGCCTCTGTCCCAGCAGCGTTAGCTAGTCCTTCAGCCAG
AGTTAGCACAATAGGTTACTTAAATGACCATGATGCTGTCACCAAGGCAATCCAAGAAGCTCGGCAAATGAAGGAGCAACTCCGACGGGA
ACAACAGGTGCTTGATGGGAAGGTGGCTGTTGTGAATAGTCTGGGTCTCAATAACTGCCGAACAGAAAAGGAAAAAACAACACTGGAGAG
TCTGACTCAGCAACTGGCAGTTAAACAGAATGAAGAAGGAAAATTTAGCCATGCAATGATGGATTTCAATCTGAGTGGAGATTCTGATGG
AAGTGCTGGAGTCTCAGAGTCAAGAATTTATAGGGAATCCCGAGGGCGTGGTAGCAATGAACCCCACATAAAGCGTCCAATGAATGCCTT
CATGGTGTGGGCTAAAGATGAACGGAGAAAGATCCTTCAAGCCTTTCCTGACATGCACAACTCCAACATCAGCAAGATATTGGGATCTCG
CTGGAAAGCTATGACAAACCTAGAGAAACAGCCATATTATGAGGAGCAAGCCCGTCTCAGCAAGCAGCACCTGGAGAAGTACCCTGACTA
TAAGTACAAGCCCAGGCCAAAGCGCACCTGCCTGGTGGATGGCAAAAAGCTGCGCATTGGTGAATACAAGGCAATCATGCGCAACAGGCG
GCAGGAAATGCGGCAGTACTTCAATGTTGGGCAACAAGCACAGATCCCCATTGCCACTGCTGGTGTTGTGTACCCTGGAGCCATCGCCAT
GGCTGGGATGCCCTCCCCTCACCTGCCCTCGGAGCACTCAAGCGTGTCTAGCAGCCCAGAGCCTGGGATGCCTGTTATCCAGAGCACTTA
CGGTGTGAAAGGAGAGGAGCCACATATCAAAGAAGAGATACAGGCCGAGGACATCAATGGAGAAATTTATGATGAGTACGACGAGGAAGA
GGATGATCCAGATGTAGATTATGGGAGTGACAGTGAAAACCATATTGCAGGACAAGCCAACTGATAAGGGTCAAAAGATTGTTGTGACCT
TAGGACTTAAAGAAGCCCTAACTGGTTCATCCTTACCAGTGGCCAAGCACATTAACTTTCTCATACACTGACTGTTACTTTAACTGTTAG
TCTTAAATAGTTGGGACATCAGCTGACTAATAGACCTCAGCCTCAAAAGGCTTGGAAAGAAAAAACAAATACAACAAGCAAACAACAATA
TCAACAACAAGAGATTGAAATAAGCTATGGGTAAAATAATGCCAGTAATTCAGCTGCTACATCCAAGCACTGAAGTCTTACCCGTCAACT
TTTTTTTTTTTTTAAATAAACTTTATGGCTGTTTGTTCTACAATGTTCTAGAAATTCTCACTCAGGTACACAGTGCCAACAAGTGGCTTG
TGAATGTGTTTTGTTGTTTTGTGCTACAATTTTTAAAAAGAAAAAAGTTTTGTTTTGTTTTTTGGGGTTTCTGGGTTTTTTCCTTTTCTT
TTTCTTTCCTTTCATTTTTTTTCTTTGTAATGCACCTGACAGAAAAAAAAGAAAAATGAATTTCTCTTTACTTCTCTCCACCTTCTCCAT
CTCTCTACTTTAAAGATGGAAGTCTGTGCATGAGGGGAAAGAGGGAAAAAGAGCCTGTTTTTAACTTCCTTGCTATCCACCACAAAATAA
GCAATTATTTTCTTTAGAGGACTTTATCTATTGCACACCACACTACATCTTTGAGCAAGTGCCAAATTTGTACTGAAGTGTTGACCAAGT
TCATTTTTTCTCTTTACTTTTTCCTTTTCCTTCTTAAGTTAGGACAGTGTTAAATCTTAGACAATCCCTTGAAAAACCTGAAATACCAGC
AGCTGGTGAGATTTGACTTTTTTTTTTAATGGAAACTGTAGGTGCTGTTCTCAGGTGAAAAGAGAGAGAGAGAGAGAGACATAAGAAATT
TAGAGAAAAATATTTTCTGATCTTGGATTTTTGTGTGTATGTATGTATGTGATTATGGTACTAATAATAGGAATAACGTTGGACCATTGT
GAGTTAAACCCACATCTGGGGATGAAATCCCACATCCTCCCAAGTGACTGGTCTAGAAATAATCTTGACCTTGACTTTGCACTTCAAATG
ACAACTTAACCAAGTATAGGGCTCAGAAATTATATTTTTAAATGTCTGATTATTATTGGATGGATCAGGTGGCCCTGTGTAATAGAGGTG
TGCATGTATAACATGGAAGCTACTAGCAAACTGCTCCCAGATGTCCTTTCTCCCTGGTCAGTTGGTTCCATTAACGTTTGCTACTTAGTG
ATTTTTGTTTTTCCTGTTGATATTTTGAGCAAAACAATCATTGTTTTCATTGAATATATTTGGCCATTTTTTCAGACAAATAGAATTAGC
TTATTTCTTCAACATTCCATCCTTTCCCGATCAGGAAATGAAACTGATGATTTTATAAGGTATTTTTCACCCCTCCATGAAGTGAGGTGG
AGGCCTTTAGCATTTCAGAAGTGTGGGCCATATGTAGTTCATGCCATAAAAAGTAGGATTTAATTAAAAGTCATTGCAGCCCAATAAAAT
GGAGCCTGGCTGCACCCAGGGATCCTTGCCACTGCTCTTCCCTTGCTGTCAGATTAATCCACTGAAGTCCAACTTTGGTTCAAGCAGAGT
ATTTGCAAAGAGCAACAACTGAATGTGATGGGACTGCTTATGTAGATTTTGCCAGCCAAATGCCAAGGCAGTTGTAGGGCCTGTACAAAT
AAATGCAAAATCATTTCAAGTCAATTGCCATTATTTGTATTGAAGTATCAGATAGATAGTAAATACTGCAACTAGTAGCTTGATGTGCTA
TAGTTTTCACTCCAGTCATCATTTTCCTATCTCACCCCCCGAAACACCACCCTAAAGTTGGATTTTTACATATAAATAAAAAAAGAATCC
CTTTTATTTTTCTCTCTCTCAGAAGACTTGCTCTGGGGTTTTGCTTGGAGGAGCTGATCATATCCTGCATGTCAGAGATTTCATTTTGTT
TGTTTTTCTGTTTGTTTGTTTTTGATGACTTTATTTACATTTGAACTGCCTCTTTTTGCTAGTGTTGTAATGATGATGATGATAAAATAA
TAATAATAATAGTAATAATAATAATAATGGTCAGCTGTTCCCAGATTAGTAAGTTATGTATAATTTATTTTATTTCTCCCTTTCTATTTT
ATTCTGCTCTGATTTGGAAGTGCAGCCAATAAGCTGTTAGATATTTAAAACAAATTTCCATCTCCAACTCATATATGTATGTATATGTAT
ATATATATATACATATATATACACACATATACACACACACACACACATTTACCCACAATTTTACTTCTCTTTCCGTAAGTTTTCTCTTTT
TTAAGAATTTTGGCCCCAACAATATCAGTTCTGATGTTTAAAACAAAGGAGTGAATTAATAGGAGGGTCGTGTTCAATCTTAATTAACTT
ATGCTCTCATCACTCATTTTAGTTATTTAATTGCCACAGTCATCTAGAGCCAATTTTTTTTTGTTTTTGTTTGTTTTGTTTTTAAGCACT
CTGGATAAGGAAAAAATAGACACTTGTTTTTATATCATTTTTATGTACAATGTGAAAACAGATTTTTAAAAAATTTGTTCTCTGTCTTTG
TTAACAAATTCCTTCCGATTTATGTGGGTTCACCTCTCACGTTTGCTGGATACTTACTTTACACCATGTTATGAAAGATGCTTTGTTTTC
ATTTCATGAGTTTGGGCTACAAGAATACTTTGTTTTAGCTCCAGGTAGATGCCATTGAAGGCATTCATGGCTGAAATCAATTCTAACACA
CTTACCGATGAATTGACAACACTTTGGTGTTTGGTCTTTTTTTTGTTATATTTTGTTTTATTTGAAGGGGAAAACAAAATTGTTAATGGT
GACTTTTAACTGCTGAAATTCAAAATTTGATTTTAGTTAGGTTTATGTCCGAGACTAAACTGTGCATGAACCGAAACAAAAAGCAAGTTC
ATACCGCTGCATTCTGTTCTCTTGTTCTGACGGTTAATTCACTGGACATCAAATTTTCTTTGCCCTAGTTTTCCCCAAAAGAAAACAAAA
GCAAAAATAGTTATATTAATGTTGAAAGTGCTTTGAAGTCACTTGATAAAAGGTGCTATGAATAGCAACTTACTGTGTTACTACATTGCC
TTTTTGGCATTGGTTGATTTATAATTTTGGTAAAGGATCCTAAAACCCTGTATTCTTTTTCTGTGCCCCATAATGACCAAAAAAGATAAA
GAAAATGAGAGTAAGATCAAAAGATCAAACTAAAACATAAACAGTCTCCTTCCTGTCTGCTTTCTTACCTATCTGTTCACACTTTATCTC
TTTCCCTTTCTCTCTCTCTCTCACATGCGCGCGCGCGCGCGCGCACACACACACACACACACACTTGCCCCAACACTGAGAAATAATCTT
GCCAGAATTCTGGTTTTTATAGTTGTTGTAGTCCGTTTCTCTAAAAATAGTCCTGTTTTCATATGAATCTAAGAGAACATTACCGGAGAA
AATAAAGTTACTCATTTATAGTTACTAATAATAAGTTAGTGATTAACTTACCACAATTGGATAAAATATAAAACTATTCTTCAGCACATT
TATACCTAAATTAGTGAAGTCCATTTGTGAAGTTCATTTGGCATCTGCAGTTAAGAGTTAACCATGTATAAAATCCCTCCCAAAGAACAT
AATCATCGTTAGAACCAAATCCTCTTATAAAGAACAAATATAAAAAAGTTTTCTGTGGTGAAGCTATTTTATAGATTTGATTTCCGGAGT
AGAATTTTACCTTAATTCACTTAAAGAAAATTAACCATTTTTTGGTCCAACTTCAGATATTTTCTTAATCCAGAAGCTGTGACTGTTCCC
AGAAGAAACCTCTTATATCACATTTAAAACATAAAAAATAATTACACTTTCACTCATTCTAATGGGTAAATTGTTGAATTGTAATAAACA
ACTGTATATTTACAAACAGGTTTATAAGGTATTTGTCTATCAAATTAATAATAAAATAAAACTTACGGGGTCTGCAAGGAAAACTATGAA
GGCCACTTAAAGTGGTTCAGGTATCCCTTTGTCTTGTAGGGCATAGCTGTTGGTTTAGCCAGGCTTTTACAGTATTTAATTTTAAAGTAT
CCTATAACTATCAACTTCCCAGGTTGAAGACGATGTGTTGAGTTTCCTACTGATTGATTGATTCCTGTCCTCCCCAGTGTTTCCGTCACT
GGTTCACTAAAACAGTATTTATATAGCTCCACTGGCTCTAAAGCTCTTAGTCCTTCTAATATTTTGGATTTTACAAGTAAAAATGGAAAA
AAAATAGAAAAGAGACAATCAAATGCCTGGAGCTTAAAACAAAGTATGTGCAACCTACCATCTCACTTGAAATTTAATAAAATAATAAGT
AATTATGTAAATATAACATAGAGTTATAGATTTATATTTTGTTCATAACACATAGTGTAATATAAGTTGTATATTTTCATGTTTTTGGTT
TTATGTTATCATTCATGCCACAATAAAAATAAAACAGGAGTTTATGTGCTCTTAAAAAAAAGATGTGGGTTGCCACCAACCTGTTTTTCG
TTTTTGTTTTTTGTTTATTTTATTTTATTTTTTTGCATTCTCCTTTTTCAGTATTACTGCCATGCAAGGCACCAATAAAAACAGCAAATG

>6488_6488_2_ARID4B-SOX5_ARID4B_chr1_235377084_ENST00000366603_SOX5_chr12_24048958_ENST00000546136_length(amino acids)=757AA_BP=6
MRMECERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNK
VMSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFG
EIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLP
PLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLG
AAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPAALASPSARVSTIGYLNDHDAV
TKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSESRIYRES
RGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVD
GKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEI

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Fusion Gene PPI Analysis for ARID4B-SOX5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARID4B-SOX5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARID4B-SOX5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARID4BC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneC0004238Atrial Fibrillation1CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0235480Paroxysmal atrial fibrillation1CTD_human
TgeneC1510586Autism Spectrum Disorders1CTD_human
TgeneC2585653Persistent atrial fibrillation1CTD_human
TgeneC3468561familial atrial fibrillation1CTD_human
TgeneC4749915Developmental and speech delay due to SOX5 deficiency1ORPHANET
TgeneC475526012p12.1 microdeletion syndrome1ORPHANET