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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ACP1-MCC (FusionGDB2 ID:HG52TG4163) |
Fusion Gene Summary for ACP1-MCC |
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Fusion gene information | Fusion gene name: ACP1-MCC | Fusion gene ID: hg52tg4163 | Hgene | Tgene | Gene symbol | ACP1 | MCC | Gene ID | 52 | 4163 |
Gene name | acid phosphatase 1 | MCC regulator of WNT signaling pathway | |
Synonyms | HAAP|LMW-PTP|LMWPTP | MCC1 | |
Cytomap | ('ACP1')('MCC') 2p25.3 | 5q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | low molecular weight phosphotyrosine protein phosphataseLMW-PTPaseacid phosphatase 1, solubleacid phosphatase of erythrocyteadipocyte acid phosphatasecytoplasmic phosphotyrosyl protein phosphataselow molecular weight cytosolic acid phosphataseprote | colorectal mutant cancer proteinMCC, WNT signaling pathway regulatormutated in colorectal cancers | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P24666 | P23508 | |
Ensembl transtripts involved in fusion gene | ENST00000272065, ENST00000272067, ENST00000405233, ENST00000407983, ENST00000439645, ENST00000484464, | ||
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 11 X 12 X 5=660 |
# samples | 4 | 12 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/660*10)=-2.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACP1 [Title/Abstract] AND MCC [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ACP1(278283)-MCC(112423491), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MCC | GO:0045184 | establishment of protein localization | 18591935 |
Tgene | MCC | GO:0050680 | negative regulation of epithelial cell proliferation | 18591935 |
Tgene | MCC | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 18591935 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for ACP1-MCC |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ACP1-MCC |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ACP1-MCC |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:278283/:112423491) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ACP1 | MCC |
FUNCTION: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity. | FUNCTION: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ACP1-MCC |
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Fusion Gene PPI Analysis for ACP1-MCC |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ACP1-MCC |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ACP1 | P24666 | DB00173 | Adenine | Small molecule | Approved|Nutraceutical |
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Related Diseases for ACP1-MCC |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACP1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | ACP1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | ACP1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Tgene | C0004352 | Autistic Disorder | 1 | CTD_human | |
Tgene | C0007113 | Rectal Carcinoma | 1 | CTD_human | |
Tgene | C0020796 | Profound Mental Retardation | 1 | CTD_human | |
Tgene | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human | |
Tgene | C0032580 | Adenomatous Polyposis Coli | 1 | CTD_human | |
Tgene | C0034885 | Rectal Neoplasms | 1 | CTD_human | |
Tgene | C0917816 | Mental deficiency | 1 | CTD_human | |
Tgene | C2713442 | Polyposis, Adenomatous Intestinal | 1 | CTD_human | |
Tgene | C2713443 | Familial Intestinal Polyposis | 1 | CTD_human | |
Tgene | C3714756 | Intellectual Disability | 1 | CTD_human |