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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CPSF2-EGR1 (FusionGDB2 ID:HG53981TG1958) |
Fusion Gene Summary for CPSF2-EGR1 |
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Fusion gene information | Fusion gene name: CPSF2-EGR1 | Fusion gene ID: hg53981tg1958 | Hgene | Tgene | Gene symbol | CPSF2 | EGR1 | Gene ID | 53981 | 1958 |
Gene name | cleavage and polyadenylation specific factor 2 | early growth response 1 | |
Synonyms | CPSF100 | AT225|G0S30|KROX-24|NGFI-A|TIS8|ZIF-268|ZNF225 | |
Cytomap | ('CPSF2')('EGR1') 14q32.12 | 5q31.2 | |
Type of gene | protein-coding | protein-coding | |
Description | cleavage and polyadenylation specificity factor subunit 2CPSF 100 kDa subunitCPSF 100kDa subunitcleavage and polyadenylation specific factor 2, 100kDacleavage and polyadenylation specificity factor 100 kDa subunit | early growth response protein 1EGR-1nerve growth factor-induced protein Atranscription factor ETR103transcription factor Zif268zinc finger protein 225zinc finger protein Krox-24 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000298875, | ||
Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 7 X 10 X 3=210 |
# samples | 4 | 11 | |
** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/210*10)=-0.932885804141463 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CPSF2 [Title/Abstract] AND EGR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CPSF2(92595058)-EGR1(137804067), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CPSF2 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage | 18688255 |
Tgene | EGR1 | GO:0006366 | transcription by RNA polymerase II | 19057511 |
Tgene | EGR1 | GO:0033233 | regulation of protein sumoylation | 19057511 |
Tgene | EGR1 | GO:0045893 | positive regulation of transcription, DNA-templated | 12560508 |
Tgene | EGR1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19057511 |
Tgene | EGR1 | GO:0098759 | cellular response to interleukin-8 | 20363028 |
Tgene | EGR1 | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 19307576 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for CPSF2-EGR1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CPSF2-EGR1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CPSF2-EGR1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:92595058/:137804067) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CPSF2-EGR1 |
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Fusion Gene PPI Analysis for CPSF2-EGR1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CPSF2-EGR1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CPSF2-EGR1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0009171 | Cocaine Abuse | 3 | CTD_human | |
Tgene | C0236736 | Cocaine-Related Disorders | 3 | CTD_human | |
Tgene | C0600427 | Cocaine Dependence | 3 | CTD_human | |
Tgene | C0008372 | Intrahepatic Cholestasis | 2 | CTD_human | |
Tgene | C0003129 | Anoxemia | 1 | CTD_human | |
Tgene | C0003130 | Anoxia | 1 | CTD_human | |
Tgene | C0004364 | Autoimmune Diseases | 1 | CTD_human | |
Tgene | C0007786 | Brain Ischemia | 1 | CTD_human | |
Tgene | C0008311 | Cholangitis | 1 | CTD_human | |
Tgene | C0008370 | Cholestasis | 1 | CTD_human | |
Tgene | C0020295 | Hydronephrosis | 1 | CTD_human | |
Tgene | C0021368 | Inflammation | 1 | CTD_human | |
Tgene | C0022116 | Ischemia | 1 | CTD_human | |
Tgene | C0024121 | Lung Neoplasms | 1 | CTD_human | |
Tgene | C0025500 | Mesothelioma | 1 | CTD_human | |
Tgene | C0032285 | Pneumonia | 1 | CTD_human | |
Tgene | C0032300 | Lobar Pneumonia | 1 | CTD_human | |
Tgene | C0033578 | Prostatic Neoplasms | 1 | CTD_human | |
Tgene | C0035126 | Reperfusion Injury | 1 | CTD_human | |
Tgene | C0087031 | Juvenile-Onset Still Disease | 1 | CTD_human | |
Tgene | C0242184 | Hypoxia | 1 | CTD_human | |
Tgene | C0242379 | Malignant neoplasm of lung | 1 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human | |
Tgene | C0700292 | Hypoxemia | 1 | CTD_human | |
Tgene | C0887898 | Experimental Lung Inflammation | 1 | CTD_human | |
Tgene | C0917798 | Cerebral Ischemia | 1 | CTD_human | |
Tgene | C2239176 | Liver carcinoma | 1 | CTD_human | |
Tgene | C3495559 | Juvenile arthritis | 1 | CTD_human | |
Tgene | C3714636 | Pneumonitis | 1 | CTD_human | |
Tgene | C3714758 | Juvenile psoriatic arthritis | 1 | CTD_human | |
Tgene | C4552091 | Polyarthritis, Juvenile, Rheumatoid Factor Negative | 1 | CTD_human | |
Tgene | C4704862 | Polyarthritis, Juvenile, Rheumatoid Factor Positive | 1 | CTD_human |