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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACP2-NR1H3 (FusionGDB2 ID:HG53TG10062)

Fusion Gene Summary for ACP2-NR1H3

check button Fusion gene summary
Fusion gene informationFusion gene name: ACP2-NR1H3
Fusion gene ID: hg53tg10062
HgeneTgene
Gene symbol

ACP2

NR1H3

Gene ID

53

10062

Gene nameacid phosphatase 2, lysosomalnuclear receptor subfamily 1 group H member 3
SynonymsLAPLXR-a|LXRA|RLD-1
Cytomap('ACP2')('NR1H3')

11p11.2|11p12-p11

11p11.2

Type of geneprotein-codingprotein-coding
Descriptionlysosomal acid phosphataseoxysterols receptor LXR-alphaliver X nuclear receptor alpha variant 1
Modification date2020031320200320
UniProtAcc

P11117

.
Ensembl transtripts involved in fusion geneENST00000256997, ENST00000527256, 
ENST00000529444, ENST00000533929, 
ENST00000537863, ENST00000525230, 
ENST00000444355, ENST00000529788, 
ENST00000530453, 
Fusion gene scores* DoF score5 X 6 X 4=1202 X 3 X 2=12
# samples 53
** MAII scorelog2(5/120*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ACP2 [Title/Abstract] AND NR1H3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACP2(47264274)-NR1H3(47282792), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNR1H3

GO:0010870

positive regulation of receptor biosynthetic process

18511497

TgeneNR1H3

GO:0010875

positive regulation of cholesterol efflux

16141411|19481530

TgeneNR1H3

GO:0032376

positive regulation of cholesterol transport

16141411

TgeneNR1H3

GO:0032570

response to progesterone

16141411

TgeneNR1H3

GO:0034145

positive regulation of toll-like receptor 4 signaling pathway

18511497

TgeneNR1H3

GO:0042632

cholesterol homeostasis

18511497

TgeneNR1H3

GO:0045893

positive regulation of transcription, DNA-templated

25661920

TgeneNR1H3

GO:0045944

positive regulation of transcription by RNA polymerase II

16141411|18511497|19481530|20219900|20837115

TgeneNR1H3

GO:0071222

cellular response to lipopolysaccharide

18511497

TgeneNR1H3

GO:2000325

regulation of nuclear receptor transcription coactivator activity

19481530



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-BC-A10S-01AACP2chr11

47264274

-NR1H3chr11

47282792

+


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Fusion Gene ORF analysis for ACP2-NR1H3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000256997ENST00000395397ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000256997ENST00000405576ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000256997ENST00000405853ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000256997ENST00000407404ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000256997ENST00000441012ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000256997ENST00000467728ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000256997ENST00000481889ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000256997ENST00000527949ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000256997ENST00000529540ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000527256ENST00000395397ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000527256ENST00000405576ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000527256ENST00000405853ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000527256ENST00000407404ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000527256ENST00000441012ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000527256ENST00000467728ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000527256ENST00000481889ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000527256ENST00000527949ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000527256ENST00000529540ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000529444ENST00000395397ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000529444ENST00000405576ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000529444ENST00000405853ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000529444ENST00000407404ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000529444ENST00000441012ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000529444ENST00000467728ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000529444ENST00000481889ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000529444ENST00000527949ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000529444ENST00000529540ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000533929ENST00000395397ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000533929ENST00000405576ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000533929ENST00000405853ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000533929ENST00000407404ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000533929ENST00000441012ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000533929ENST00000467728ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000533929ENST00000481889ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000533929ENST00000527949ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000533929ENST00000529540ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000537863ENST00000395397ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000537863ENST00000405576ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000537863ENST00000405853ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000537863ENST00000407404ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000537863ENST00000441012ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000537863ENST00000467728ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000537863ENST00000481889ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000537863ENST00000527949ACP2chr11

47264274

-NR1H3chr11

47282792

+
5CDS-3UTRENST00000537863ENST00000529540ACP2chr11

47264274

-NR1H3chr11

47282792

+
5UTR-3UTRENST00000525230ENST00000395397ACP2chr11

47264274

-NR1H3chr11

47282792

+
5UTR-3UTRENST00000525230ENST00000405576ACP2chr11

47264274

-NR1H3chr11

47282792

+
5UTR-3UTRENST00000525230ENST00000405853ACP2chr11

47264274

-NR1H3chr11

47282792

+
5UTR-3UTRENST00000525230ENST00000407404ACP2chr11

47264274

-NR1H3chr11

47282792

+
5UTR-3UTRENST00000525230ENST00000441012ACP2chr11

47264274

-NR1H3chr11

47282792

+
5UTR-3UTRENST00000525230ENST00000467728ACP2chr11

47264274

-NR1H3chr11

47282792

+
5UTR-3UTRENST00000525230ENST00000481889ACP2chr11

47264274

-NR1H3chr11

47282792

+
5UTR-3UTRENST00000525230ENST00000527949ACP2chr11

47264274

-NR1H3chr11

47282792

+
5UTR-3UTRENST00000525230ENST00000529540ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000444355ENST00000395397ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000444355ENST00000405576ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000444355ENST00000405853ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000444355ENST00000407404ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000444355ENST00000441012ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000444355ENST00000467728ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000444355ENST00000481889ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000444355ENST00000527949ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000444355ENST00000529540ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000529788ENST00000395397ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000529788ENST00000405576ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000529788ENST00000405853ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000529788ENST00000407404ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000529788ENST00000441012ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000529788ENST00000467728ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000529788ENST00000481889ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000529788ENST00000527949ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000529788ENST00000529540ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000530453ENST00000395397ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000530453ENST00000405576ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000530453ENST00000405853ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000530453ENST00000407404ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000530453ENST00000441012ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000530453ENST00000467728ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000530453ENST00000481889ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000530453ENST00000527949ACP2chr11

47264274

-NR1H3chr11

47282792

+
intron-3UTRENST00000530453ENST00000529540ACP2chr11

47264274

-NR1H3chr11

47282792

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ACP2-NR1H3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACP2chr1147264273-NR1H3chr1147282791+4.15E-050.9999584
ACP2chr1147264273-NR1H3chr1147282791+4.15E-050.9999584


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACP2-NR1H3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:47264274/:47282792)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACP2

P11117

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ACP2-NR1H3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ACP2-NR1H3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACP2-NR1H3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACP2-NR1H3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0008370Cholestasis1CTD_human
TgeneC0015695Fatty Liver1CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC2711227Steatohepatitis1CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human