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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATRX-OGT (FusionGDB2 ID:HG546TG8473)

Fusion Gene Summary for ATRX-OGT

check button Fusion gene summary
Fusion gene informationFusion gene name: ATRX-OGT
Fusion gene ID: hg546tg8473
HgeneTgene
Gene symbol

ATRX

OGT

Gene ID

546

8473

Gene nameATRX chromatin remodelerO-linked N-acetylglucosamine (GlcNAc) transferase
SynonymsJMS|MRX52|RAD54|RAD54L|XH2|XNP|ZNF-HXHINCUT-1|HRNT1|MRX106|O-GLCNAC|OGT1
Cytomap('ATRX')('OGT')

Xq21.1

Xq13.1

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ATRXATP-dependent helicase ATRXX-linked helicase IIX-linked nuclear proteinalpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitO-GlcNAc transferase p110 subunitO-GlcNAc transferase subunit p110O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminy
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000373341, ENST00000373344, 
ENST00000395603, ENST00000480283, 
Fusion gene scores* DoF score17 X 13 X 9=19897 X 7 X 5=245
# samples 238
** MAII scorelog2(23/1989*10)=-3.11233750988937
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATRX [Title/Abstract] AND OGT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATRX(76972607)-OGT(70775803), # samples:1
Anticipated loss of major functional domain due to fusion event.ATRX-OGT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATRX-OGT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATRX-OGT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATRX-OGT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATRX-OGT seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ATRX-OGT seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ATRX-OGT seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ATRX-OGT seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATRX

GO:0006334

nucleosome assembly

20651253

HgeneATRX

GO:0006338

chromatin remodeling

20651253

TgeneOGT

GO:0006110

regulation of glycolytic process

22923583

TgeneOGT

GO:0006493

protein O-linked glycosylation

21240259|21285374|22923583|23222540|23352454|24474760

TgeneOGT

GO:0006915

apoptotic process

20824293

TgeneOGT

GO:0032868

response to insulin

18288188

TgeneOGT

GO:0035020

regulation of Rac protein signal transduction

18288188

TgeneOGT

GO:0043981

histone H4-K5 acetylation

20018852

TgeneOGT

GO:0043982

histone H4-K8 acetylation

20018852

TgeneOGT

GO:0043984

histone H4-K16 acetylation

20018852

TgeneOGT

GO:0045862

positive regulation of proteolysis

21285374

TgeneOGT

GO:0045944

positive regulation of transcription by RNA polymerase II

23222540|23353889

TgeneOGT

GO:0046626

regulation of insulin receptor signaling pathway

18288188

TgeneOGT

GO:0048015

phosphatidylinositol-mediated signaling

18288188


check buttonFusion gene breakpoints across ATRX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across OGT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-7695ATRXchrX

76972607

-OGTchrX

70775803

+


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Fusion Gene ORF analysis for ATRX-OGT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373341ENST00000498566ATRXchrX

76972607

-OGTchrX

70775803

+
5CDS-intronENST00000373344ENST00000498566ATRXchrX

76972607

-OGTchrX

70775803

+
5CDS-intronENST00000395603ENST00000498566ATRXchrX

76972607

-OGTchrX

70775803

+
5UTR-3CDSENST00000480283ENST00000373701ATRXchrX

76972607

-OGTchrX

70775803

+
5UTR-3CDSENST00000480283ENST00000373719ATRXchrX

76972607

-OGTchrX

70775803

+
5UTR-intronENST00000480283ENST00000498566ATRXchrX

76972607

-OGTchrX

70775803

+
Frame-shiftENST00000373344ENST00000373701ATRXchrX

76972607

-OGTchrX

70775803

+
Frame-shiftENST00000373344ENST00000373719ATRXchrX

76972607

-OGTchrX

70775803

+
Frame-shiftENST00000395603ENST00000373701ATRXchrX

76972607

-OGTchrX

70775803

+
Frame-shiftENST00000395603ENST00000373719ATRXchrX

76972607

-OGTchrX

70775803

+
In-frameENST00000373341ENST00000373701ATRXchrX

76972607

-OGTchrX

70775803

+
In-frameENST00000373341ENST00000373719ATRXchrX

76972607

-OGTchrX

70775803

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373341ATRXchrX76972607-ENST00000373719OGTchrX70775803+44331131522329725
ENST00000373341ATRXchrX76972607-ENST00000373701OGTchrX70775803+23521131522329725

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373341ENST00000373719ATRXchrX76972607-OGTchrX70775803+0.0006791430.99932086
ENST00000373341ENST00000373701ATRXchrX76972607-OGTchrX70775803+0.0040883010.9959117

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Fusion Genomic Features for ATRX-OGT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATRXchrX76972607-OGTchrX70775803+5.32E-101
ATRXchrX76972607-OGTchrX70775803+5.32E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATRX-OGT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:76972607/chrX:70775803)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneOGTchrX:76972607chrX:70775803ENST00000373701622487_5032981037.0MotifNuclear localization signal
TgeneOGTchrX:76972607chrX:70775803ENST00000373719622487_5033081047.0MotifNuclear localization signal
TgeneOGTchrX:76972607chrX:70775803ENST00000373701622906_9082981037.0Nucleotide bindingUDP
TgeneOGTchrX:76972607chrX:70775803ENST00000373701622911_9142981037.0Nucleotide bindingUDP
TgeneOGTchrX:76972607chrX:70775803ENST00000373701622930_9322981037.0Nucleotide bindingUDP
TgeneOGTchrX:76972607chrX:70775803ENST00000373719622906_9083081047.0Nucleotide bindingUDP
TgeneOGTchrX:76972607chrX:70775803ENST00000373719622911_9143081047.0Nucleotide bindingUDP
TgeneOGTchrX:76972607chrX:70775803ENST00000373719622930_9323081047.0Nucleotide bindingUDP
TgeneOGTchrX:76972607chrX:70775803ENST00000373701622991_10102981037.0RegionNote=Required for phosphatidylinositol 3%2C4%2C5-triphosphate binding
TgeneOGTchrX:76972607chrX:70775803ENST00000373719622991_10103081047.0RegionNote=Required for phosphatidylinositol 3%2C4%2C5-triphosphate binding
TgeneOGTchrX:76972607chrX:70775803ENST00000373701622327_3602981037.0RepeatNote=TPR 9
TgeneOGTchrX:76972607chrX:70775803ENST00000373701622361_3942981037.0RepeatNote=TPR 10
TgeneOGTchrX:76972607chrX:70775803ENST00000373701622395_4282981037.0RepeatNote=TPR 11
TgeneOGTchrX:76972607chrX:70775803ENST00000373701622429_4622981037.0RepeatNote=TPR 12
TgeneOGTchrX:76972607chrX:70775803ENST00000373701622463_4732981037.0RepeatNote=TPR 13%3B truncated
TgeneOGTchrX:76972607chrX:70775803ENST00000373719622327_3603081047.0RepeatNote=TPR 9
TgeneOGTchrX:76972607chrX:70775803ENST00000373719622361_3943081047.0RepeatNote=TPR 10
TgeneOGTchrX:76972607chrX:70775803ENST00000373719622395_4283081047.0RepeatNote=TPR 11
TgeneOGTchrX:76972607chrX:70775803ENST00000373719622429_4623081047.0RepeatNote=TPR 12
TgeneOGTchrX:76972607chrX:70775803ENST00000373719622463_4733081047.0RepeatNote=TPR 13%3B truncated

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2351151_1156442493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2351166_1169442493.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2351202_1206442493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2351259_1266442493.0Compositional biasNote=Poly-Asp
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2351443_1466442493.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2351499_1502442493.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2351929_1939442493.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2351941_1948442493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2352222_2225442493.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2352262_2265442493.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2352420_2425442493.0Compositional biasNote=Poly-Gln
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-235745_750442493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2341151_1156442455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2341166_1169442455.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2341202_1206442455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2341259_1266442455.0Compositional biasNote=Poly-Asp
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2341443_1466442455.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2341499_1502442455.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2341929_1939442455.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2341941_1948442455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2342222_2225442455.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2342262_2265442455.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2342420_2425442455.0Compositional biasNote=Poly-Gln
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-234745_750442455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2351581_1768442493.0DomainHelicase ATP-binding
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-235159_296442493.0DomainADD
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2352025_2205442493.0DomainHelicase C-terminal
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2341581_1768442455.0DomainHelicase ATP-binding
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-234159_296442455.0DomainADD
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2342025_2205442455.0DomainHelicase C-terminal
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2351719_1722442493.0MotifNote=DEGH box
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-235581_594442493.0MotifNote=PxVxL motif
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2341719_1722442455.0MotifNote=DEGH box
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-234581_594442455.0MotifNote=PxVxL motif
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2351594_1601442493.0Nucleotide bindingATP
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2341594_1601442455.0Nucleotide bindingATP
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-235170_206442493.0Zinc fingerGATA-type%3B atypical
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-235217_272442493.0Zinc fingerPHD-type%3B atypical
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-234170_206442455.0Zinc fingerGATA-type%3B atypical
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-234217_272442455.0Zinc fingerPHD-type%3B atypical
TgeneOGTchrX:76972607chrX:70775803ENST00000373701622123_1562981037.0RepeatNote=TPR 3
TgeneOGTchrX:76972607chrX:70775803ENST00000373701622157_1902981037.0RepeatNote=TPR 4
TgeneOGTchrX:76972607chrX:70775803ENST00000373701622191_2242981037.0RepeatNote=TPR 5
TgeneOGTchrX:76972607chrX:70775803ENST0000037370162221_542981037.0RepeatNote=TPR 1
TgeneOGTchrX:76972607chrX:70775803ENST00000373701622225_2582981037.0RepeatNote=TPR 6
TgeneOGTchrX:76972607chrX:70775803ENST00000373701622259_2922981037.0RepeatNote=TPR 7
TgeneOGTchrX:76972607chrX:70775803ENST00000373701622293_3262981037.0RepeatNote=TPR 8
TgeneOGTchrX:76972607chrX:70775803ENST0000037370162289_1222981037.0RepeatNote=TPR 2
TgeneOGTchrX:76972607chrX:70775803ENST00000373719622123_1563081047.0RepeatNote=TPR 3
TgeneOGTchrX:76972607chrX:70775803ENST00000373719622157_1903081047.0RepeatNote=TPR 4
TgeneOGTchrX:76972607chrX:70775803ENST00000373719622191_2243081047.0RepeatNote=TPR 5
TgeneOGTchrX:76972607chrX:70775803ENST0000037371962221_543081047.0RepeatNote=TPR 1
TgeneOGTchrX:76972607chrX:70775803ENST00000373719622225_2583081047.0RepeatNote=TPR 6
TgeneOGTchrX:76972607chrX:70775803ENST00000373719622259_2923081047.0RepeatNote=TPR 7
TgeneOGTchrX:76972607chrX:70775803ENST00000373719622293_3263081047.0RepeatNote=TPR 8
TgeneOGTchrX:76972607chrX:70775803ENST0000037371962289_1223081047.0RepeatNote=TPR 2


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Fusion Gene Sequence for ATRX-OGT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8357_8357_1_ATRX-OGT_ATRX_chrX_76972607_ENST00000373341_OGT_chrX_70775803_ENST00000373701_length(transcript)=2352nt_BP=113nt
TGAAAGCAAGTTGAATACATTGGTGCAGAAGCTTCATGACTTCCTTGCACACTCATCAGAAGAATCTGAAGAAACAAGTTCTCCTCCACG
ACTTGCAATGAATCAAAACACAGGTTGCTGAAGCAGAAGATTGTTATAATACAGCTCTCCGTCTGTGTCCCACCCATGCAGACTCTCTGA
ATAACCTAGCCAATATCAAACGAGAACAGGGAAACATTGAAGAGGCAGTTCGCTTGTATCGTAAAGCATTAGAAGTCTTCCCAGAGTTTG
CTGCTGCCCATTCAAATTTAGCAAGTGTACTGCAGCAGCAGGGAAAACTGCAGGAAGCTCTGATGCATTATAAGGAGGCTATTCGAATCA
GTCCTACCTTTGCTGATGCCTACTCTAATATGGGAAACACTCTAAAGGAGATGCAGGATGTTCAGGGAGCCTTGCAGTGTTATACGCGTG
CCATCCAAATTAATCCTGCATTTGCAGATGCACATAGCAATCTGGCTTCCATTCATAAGGATTCAGGGAATATTCCAGAAGCCATAGCTT
CTTACCGCACGGCTCTGAAACTTAAGCCTGATTTTCCTGATGCTTATTGTAACTTGGCTCATTGCCTGCAGATTGTCTGTGATTGGACAG
ACTATGATGAGCGAATGAAGAAGTTGGTCAGTATTGTGGCTGACCAGTTAGAGAAGAATAGGTTGCCTTCTGTGCATCCTCATCATAGTA
TGCTATATCCTCTTTCTCATGGCTTCAGGAAGGCTATTGCTGAGAGGCACGGCAACCTGTGCTTAGATAAGATTAATGTTCTTCATAAAC
CACCATATGAACATCCAAAAGACTTGAAGCTCAGTGATGGTCGGCTGCGTGTAGGATATGTGAGTTCCGACTTTGGGAATCATCCTACTT
CTCACCTTATGCAGTCTATTCCAGGCATGCACAATCCTGATAAATTTGAGGTGTTCTGTTATGCCCTGAGCCCAGACGATGGCACAAACT
TCCGAGTGAAGGTGATGGCAGAAGCCAATCATTTCATTGATCTTTCTCAGATTCCATGCAATGGAAAAGCAGCTGATCGCATCCATCAGG
ATGGAATTCATATCCTTGTAAATATGAATGGCTATACTAAGGGCGCTCGAAATGAGCTTTTTGCTCTCAGGCCAGCTCCTATTCAGGCAA
TGTGGCTGGGATACCCTGGGACGAGTGGTGCGCTTTTCATGGATTATATTATCACTGATCAGGAAACTTCGCCAGCTGAAGTTGCTGAGC
AGTATTCCGAGAAATTGGCTTATATGCCCCACACTTTTTTTATTGGTGATCATGCTAATATGTTCCCTCACCTGAAGAAAAAAGCAGTCA
TCGATTTTAAGTCCAATGGGCACATTTATGACAATCGGATAGTTCTGAATGGCATCGACCTCAAAGCATTTCTTGATAGTCTACCAGATG
TGAAAATTGTCAAGATGAAGTGTCCTGATGGAGGAGACAATGCAGATAGCAGTAACACAGCTCTTAATATGCCTGTTATTCCTATGAATA
CTATTGCAGAAGCAGTTATTGAAATGATTAACCGAGGACAGATTCAAATAACAATTAATGGATTCAGTATTAGCAATGGACTGGCAACTA
CTCAGATCAACAATAAGGCTGCAACTGGAGAGGAGGTTCCCCGTACCATTATTGTAACCACCCGTTCTCAGTACGGGTTACCAGAAGATG
CCATCGTATACTGTAACTTTAATCAGTTGTATAAAATTGACCCTTCTACTTTGCAGATGTGGGCAAACATTCTGAAGCGTGTTCCCAATA
GTGTACTCTGGCTGTTGCGTTTTCCAGCAGTAGGAGAACCTAATATTCAACAGTATGCACAAAACATGGGCCTGCCCCAGAACCGTATCA
TTTTTTCACCTGTTGCTCCTAAAGAGGAACACGTCAGGAGAGGCCAGCTGGCTGATGTCTGCTTGGACACTCCACTCTGTAATGGGCACA
CCACAGGGATGGATGTCCTCTGGGCAGGGACCCCCATGGTGACTATGCCAGGAGAGACTCTTGCTTCTCGAGTTGCAGCATCCCAGCTCA
CTTGCTTAGGTTGTCTTGAGCTTATTGCTAAAAACAGACAAGAATATGAAGACATAGCTGTGAAGCTGGGAACTGATCTAGAATACCTGA
AGAAAGTTCGTGGCAAAGTCTGGAAGCAAAGAATATCTAGCCCTCTGTTCAACACCAAACAATACACAATGGAACTAGAGCGGCTCTATC
TACAGATGTGGGAGCATTATGCAGCTGGCAACAAACCTGACCACATGATTAAGCCTGTTGAAGTCACTGAGTCAGCATAAATAAAGACTG

>8357_8357_1_ATRX-OGT_ATRX_chrX_76972607_ENST00000373341_OGT_chrX_70775803_ENST00000373701_length(amino acids)=725AA_BP=
MCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDV
QGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNR
LPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCY
ALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQ
ETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNTA
LNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMW
ANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETL
ASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIKPVE

--------------------------------------------------------------
>8357_8357_2_ATRX-OGT_ATRX_chrX_76972607_ENST00000373341_OGT_chrX_70775803_ENST00000373719_length(transcript)=4433nt_BP=113nt
TGAAAGCAAGTTGAATACATTGGTGCAGAAGCTTCATGACTTCCTTGCACACTCATCAGAAGAATCTGAAGAAACAAGTTCTCCTCCACG
ACTTGCAATGAATCAAAACACAGGTTGCTGAAGCAGAAGATTGTTATAATACAGCTCTCCGTCTGTGTCCCACCCATGCAGACTCTCTGA
ATAACCTAGCCAATATCAAACGAGAACAGGGAAACATTGAAGAGGCAGTTCGCTTGTATCGTAAAGCATTAGAAGTCTTCCCAGAGTTTG
CTGCTGCCCATTCAAATTTAGCAAGTGTACTGCAGCAGCAGGGAAAACTGCAGGAAGCTCTGATGCATTATAAGGAGGCTATTCGAATCA
GTCCTACCTTTGCTGATGCCTACTCTAATATGGGAAACACTCTAAAGGAGATGCAGGATGTTCAGGGAGCCTTGCAGTGTTATACGCGTG
CCATCCAAATTAATCCTGCATTTGCAGATGCACATAGCAATCTGGCTTCCATTCATAAGGATTCAGGGAATATTCCAGAAGCCATAGCTT
CTTACCGCACGGCTCTGAAACTTAAGCCTGATTTTCCTGATGCTTATTGTAACTTGGCTCATTGCCTGCAGATTGTCTGTGATTGGACAG
ACTATGATGAGCGAATGAAGAAGTTGGTCAGTATTGTGGCTGACCAGTTAGAGAAGAATAGGTTGCCTTCTGTGCATCCTCATCATAGTA
TGCTATATCCTCTTTCTCATGGCTTCAGGAAGGCTATTGCTGAGAGGCACGGCAACCTGTGCTTAGATAAGATTAATGTTCTTCATAAAC
CACCATATGAACATCCAAAAGACTTGAAGCTCAGTGATGGTCGGCTGCGTGTAGGATATGTGAGTTCCGACTTTGGGAATCATCCTACTT
CTCACCTTATGCAGTCTATTCCAGGCATGCACAATCCTGATAAATTTGAGGTGTTCTGTTATGCCCTGAGCCCAGACGATGGCACAAACT
TCCGAGTGAAGGTGATGGCAGAAGCCAATCATTTCATTGATCTTTCTCAGATTCCATGCAATGGAAAAGCAGCTGATCGCATCCATCAGG
ATGGAATTCATATCCTTGTAAATATGAATGGCTATACTAAGGGCGCTCGAAATGAGCTTTTTGCTCTCAGGCCAGCTCCTATTCAGGCAA
TGTGGCTGGGATACCCTGGGACGAGTGGTGCGCTTTTCATGGATTATATTATCACTGATCAGGAAACTTCGCCAGCTGAAGTTGCTGAGC
AGTATTCCGAGAAATTGGCTTATATGCCCCACACTTTTTTTATTGGTGATCATGCTAATATGTTCCCTCACCTGAAGAAAAAAGCAGTCA
TCGATTTTAAGTCCAATGGGCACATTTATGACAATCGGATAGTTCTGAATGGCATCGACCTCAAAGCATTTCTTGATAGTCTACCAGATG
TGAAAATTGTCAAGATGAAGTGTCCTGATGGAGGAGACAATGCAGATAGCAGTAACACAGCTCTTAATATGCCTGTTATTCCTATGAATA
CTATTGCAGAAGCAGTTATTGAAATGATTAACCGAGGACAGATTCAAATAACAATTAATGGATTCAGTATTAGCAATGGACTGGCAACTA
CTCAGATCAACAATAAGGCTGCAACTGGAGAGGAGGTTCCCCGTACCATTATTGTAACCACCCGTTCTCAGTACGGGTTACCAGAAGATG
CCATCGTATACTGTAACTTTAATCAGTTGTATAAAATTGACCCTTCTACTTTGCAGATGTGGGCAAACATTCTGAAGCGTGTTCCCAATA
GTGTACTCTGGCTGTTGCGTTTTCCAGCAGTAGGAGAACCTAATATTCAACAGTATGCACAAAACATGGGCCTGCCCCAGAACCGTATCA
TTTTTTCACCTGTTGCTCCTAAAGAGGAACACGTCAGGAGAGGCCAGCTGGCTGATGTCTGCTTGGACACTCCACTCTGTAATGGGCACA
CCACAGGGATGGATGTCCTCTGGGCAGGGACCCCCATGGTGACTATGCCAGGAGAGACTCTTGCTTCTCGAGTTGCAGCATCCCAGCTCA
CTTGCTTAGGTTGTCTTGAGCTTATTGCTAAAAACAGACAAGAATATGAAGACATAGCTGTGAAGCTGGGAACTGATCTAGAATACCTGA
AGAAAGTTCGTGGCAAAGTCTGGAAGCAAAGAATATCTAGCCCTCTGTTCAACACCAAACAATACACAATGGAACTAGAGCGGCTCTATC
TACAGATGTGGGAGCATTATGCAGCTGGCAACAAACCTGACCACATGATTAAGCCTGTTGAAGTCACTGAGTCAGCATAAATAAAGACTG
CACAGGAGAATTACCCCTATACCTGAGCCTCAACCTTCTGGGGGAAAGGGAACTAGATAACATACTTCTTACTTGTCTGTACAGTACCTT
GTTGCAGATGGGTGATATATAATGGTAATAGAATAGCACAGCCAGACTTGCTTCCTGCATGGTAGGGAGAGACACAAAAGATGGGAAACT
GCTTTTCCACAAGGAATCTCCGTAGAATTTTGCGGCGACCAGATGGTGCATAGGTCTGGAAGGTCTGATCTCCCTTGGTCTTCCATGGGA
TGGTTAGTGTGGAGGGGAGATATAGATTGTCCGGCCGCTTTGTGATTCCATGGATTGATTCAGTCTTCTGGATTTTTTTTTCTTTATATT
TTGGGTACTGGAGCTTTTAAAAATGTTTGGTTTCAGGTATTTTTATTCATGTGAAGTGTATATGATTCTCTTGAGATAAGGTTTTAAGCT
AAAATGTTACTCCCTGTTTTAGTTTCTGAACTCTGACAGATTGACAGGGACTTTGCTGGTGTAGTCTTTTTATAGGTTTTATAAACCACT
TGAGCCTATATCAGTCGTTTTAGTGTCTGACCTAATATTTGGAGCTATCAGTGCTTTGTTGATTTAGATGATGACTCAAGATTTTTTCTG
GTCCATTTCCCATTTCCTTTTCTTCCCTGACCCCCATACCCTCACCCTTAAAATTCTCCTGTAACTCAACTAACAAAATCAAGCCTGATT
CAAAACATCCTAGGGTGTTTTAAACACACCATCTGGTGCCAAATGAAGATTTTTAGGAGTGATTACTAATTATCAAGGGCACAGTTGTGG
TACTGTCATTGATAATAATATAGTTTTTTTTTTTTTCCTAATTTTGACCTGTTTCACCAGTGTTTTACCCTTGACTGCCCCTTCTATGCT
GCTTCCAAAAGTGATAGTGTGTGTAAGATTTTTACCTTCCTTTCTAAAGTTTTTTTTTTTTTTTTTTAAGTGAGTCCTGTTCTTCCTATT
TCTTTCAGCAGAAATGAAATCCCAGGTAAGTATAAGTATTCAAGTATTTGATCAGTAAGTCACAGTTATCTCCAGTGCATTAAATAACCT
TCATCAAGAAATAGGTTATAGGTAAAATCTCTGAAGGATCATCTATGTATTCAAGTAATTATTTTTTAGATAATAACTGTCTTCTGGACT
TGGTCTTGAAGTCTGTACAGATTCAGCCTCAGTAGTAGCGAACTGCACTGCTGTTTGGTTTGGAGTACAAATTAGACTTATAGTCCTCCT
GGAACTTGAGTTATTAAAATCATAGGAATAAAATTATGGGATCTCAACAAAGGGTCGAGGGTTTGAGGCTTAAACAAGCCAACATATGAA
TATATGTTTTGTCTCGCTATACTGCACTTACGCTATCCAGTTGCAGGTAATTTTTTGTCTGCTAGTAGTGTTCTAGATTATGTCTTTCCA
AAGCGCTGAGGCTGTGCACCTATTCTGTAGTTGCAGCTGATGCCTGAATGTATCCTAGCTGACAAATTATTGATTAATAAGAACTTGAAT
TTCTGGAAGATTCTTACTGTTAACCAAATTTTGAGCAAGGAGTCTCAAAGGTAATTCTGAACCAGAATTACATGTTAATGAACAGTGTAC
CTTTTAACAGTGTAAATCACGGAATATCCGTGAAGGGATTTCTTAATTTATTTTTTACCGGTTGATTGAAATATCAGTTAAAGGTTGCCA
GCATGGTTGCAGATAAACTGATGTTTGAAATTCGCTGAAATACTTAATGTGGAATAGGATAATATACTTCCAATGCCCTCAAGGCTGTGA
CCTTACAGCCATTTTACATAGCACATCATTCCTCCTATAGGGATGAACTTTTTCCTGGCACGAAAAGTAGCCGCTCTGGTTGAAGCTTTG
CTTATTGTAACAGGCTTTTATTTCCAGGTAATATGTCTTGGAAGACTTAATTCTGATTAGAGATATAGATATTACTGGAAACTAATTGTT
TTTTTTCTATTGTACTCTGCTTTATCAAAGAAGTAAAACATTTAAATCGTACTACAGAAATTAAGATGTTGTCTTGCGATCCTTAATAAA

>8357_8357_2_ATRX-OGT_ATRX_chrX_76972607_ENST00000373341_OGT_chrX_70775803_ENST00000373719_length(amino acids)=725AA_BP=
MCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDV
QGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNR
LPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCY
ALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQ
ETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNTA
LNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMW
ANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETL
ASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIKPVE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATRX-OGT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2351189_132644.3333333333333362493.0DAXX
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2341189_132644.3333333333333362455.0DAXX
HgeneATRXchrX:76972607chrX:70775803ENST00000373344-2352010_228044.3333333333333362493.0MECP2
HgeneATRXchrX:76972607chrX:70775803ENST00000395603-2342010_228044.3333333333333362455.0MECP2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATRX-OGT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATRX-OGT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATRXC0796003Juberg-Marsidi syndrome17CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneATRXC1845055ALPHA-THALASSEMIA/MENTAL RETARDATION SYNDROME, NONDELETION TYPE, X-LINKED16CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneATRXC0017638Glioma2CTD_human
HgeneATRXC0027819Neuroblastoma2CTD_human
HgeneATRXC0259783mixed gliomas2CTD_human
HgeneATRXC0555198Malignant Glioma2CTD_human
HgeneATRXC0010417Cryptorchidism1CTD_human
HgeneATRXC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneATRXC0018273Growth Disorders1CTD_human
HgeneATRXC0030297Pancreatic Neoplasm1CTD_human
HgeneATRXC0030846Penile Diseases1CTD_human
HgeneATRXC0039978Thoracic Diseases1CTD_human
HgeneATRXC0206754Neuroendocrine Tumors1CTD_human
HgeneATRXC0346647Malignant neoplasm of pancreas1CTD_human
HgeneATRXC0376634Craniofacial Abnormalities1CTD_human
HgeneATRXC0431663Bilateral Cryptorchidism1CTD_human
HgeneATRXC0431664Unilateral Cryptorchidism1CTD_human
HgeneATRXC0585216Alpha-Thalassemia Myelodysplasia Syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneATRXC0796159Mental retardation Smith Fineman Myers type1ORPHANET
HgeneATRXC1136249Mental Retardation, X-Linked1CTD_human
HgeneATRXC1563730Abdominal Cryptorchidism1CTD_human
HgeneATRXC1563731Inguinal Cryptorchidism1CTD_human
HgeneATRXC2713368Hematopoetic Myelodysplasia1CTD_human
HgeneATRXC3463824MYELODYSPLASTIC SYNDROME1CTD_human
TgeneC4478379MENTAL RETARDATION, X-LINKED 1063GENOMICS_ENGLAND;UNIPROT