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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MPHOSPH8-ATP8A2 (FusionGDB2 ID:HG54737TG51761)

Fusion Gene Summary for MPHOSPH8-ATP8A2

check button Fusion gene summary
Fusion gene informationFusion gene name: MPHOSPH8-ATP8A2
Fusion gene ID: hg54737tg51761
HgeneTgene
Gene symbol

MPHOSPH8

ATP8A2

Gene ID

54737

51761

Gene nameM-phase phosphoprotein 8ATPase phospholipid transporting 8A2
SynonymsHSMPP8|TWA3|mpp8ATP|ATPIB|CAMRQ4|IB|ML-1
Cytomap('MPHOSPH8')('ATP8A2')

13q12.11

13q12.13

Type of geneprotein-codingprotein-coding
DescriptionM-phase phosphoprotein 8M-phase phosphoprotein, mppM-phase phosphoprotein, mpp8two hybrid-associated protein 3 with RanBPMphospholipid-transporting ATPase IBATPase, aminophospholipid transporter, class I, type 8A, member 2ATPase, aminophospholipid transporter-like, class I, type 8A, member 2P4-ATPase flippase complex alpha subunit ATP8A2probable phospholipid-transporting
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000361479, ENST00000414242, 
ENST00000496525, 
Fusion gene scores* DoF score8 X 11 X 5=44013 X 13 X 7=1183
# samples 1215
** MAII scorelog2(12/440*10)=-1.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1183*10)=-2.97941566784391
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MPHOSPH8 [Title/Abstract] AND ATP8A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMPHOSPH8(20208101)-ATP8A2(26535713), # samples:1
Anticipated loss of major functional domain due to fusion event.MPHOSPH8-ATP8A2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MPHOSPH8-ATP8A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMPHOSPH8

GO:0045814

negative regulation of gene expression, epigenetic

26022416|28581500|29211708

HgeneMPHOSPH8

GO:0090309

positive regulation of methylation-dependent chromatin silencing

28581500|29211708


check buttonFusion gene breakpoints across MPHOSPH8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ATP8A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AY-A54L-01AMPHOSPH8chr13

20208101

+ATP8A2chr13

26535713

+


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Fusion Gene ORF analysis for MPHOSPH8-ATP8A2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000361479ENST00000491840MPHOSPH8chr13

20208101

+ATP8A2chr13

26535713

+
5CDS-intronENST00000414242ENST00000491840MPHOSPH8chr13

20208101

+ATP8A2chr13

26535713

+
In-frameENST00000361479ENST00000255283MPHOSPH8chr13

20208101

+ATP8A2chr13

26535713

+
In-frameENST00000361479ENST00000381655MPHOSPH8chr13

20208101

+ATP8A2chr13

26535713

+
In-frameENST00000414242ENST00000255283MPHOSPH8chr13

20208101

+ATP8A2chr13

26535713

+
In-frameENST00000414242ENST00000381655MPHOSPH8chr13

20208101

+ATP8A2chr13

26535713

+
intron-3CDSENST00000496525ENST00000255283MPHOSPH8chr13

20208101

+ATP8A2chr13

26535713

+
intron-3CDSENST00000496525ENST00000381655MPHOSPH8chr13

20208101

+ATP8A2chr13

26535713

+
intron-intronENST00000496525ENST00000491840MPHOSPH8chr13

20208101

+ATP8A2chr13

26535713

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000414242MPHOSPH8chr1320208101+ENST00000381655ATP8A2chr1326535713+6564314101697198
ENST00000414242MPHOSPH8chr1320208101+ENST00000255283ATP8A2chr1326535713+954314101697198
ENST00000361479MPHOSPH8chr1320208101+ENST00000381655ATP8A2chr1326535713+653128168664198
ENST00000361479MPHOSPH8chr1320208101+ENST00000255283ATP8A2chr1326535713+92128168664198

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000414242ENST00000381655MPHOSPH8chr1320208101+ATP8A2chr1326535713+0.0011405040.9988595
ENST00000414242ENST00000255283MPHOSPH8chr1320208101+ATP8A2chr1326535713+0.001879540.9981205
ENST00000361479ENST00000381655MPHOSPH8chr1320208101+ATP8A2chr1326535713+0.0011465530.99885345
ENST00000361479ENST00000255283MPHOSPH8chr1320208101+ATP8A2chr1326535713+0.0021730280.997827

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Fusion Genomic Features for MPHOSPH8-ATP8A2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MPHOSPH8-ATP8A2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:20208101/chr13:26535713)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATP8A2chr13:20208101chr13:26535713ENST0000038165532371085_118810611189.0Topological domainCytoplasmic
TgeneATP8A2chr13:20208101chr13:26535713ENST0000038165532371064_108410611189.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMPHOSPH8chr13:20208101chr13:26535713ENST00000361479+114151_25671861.0Compositional biasNote=Lys-rich
HgeneMPHOSPH8chr13:20208101chr13:26535713ENST00000414242+113151_25671868.0Compositional biasNote=Lys-rich
HgeneMPHOSPH8chr13:20208101chr13:26535713ENST00000361479+11459_11871861.0DomainChromo
HgeneMPHOSPH8chr13:20208101chr13:26535713ENST00000414242+11359_11871868.0DomainChromo
HgeneMPHOSPH8chr13:20208101chr13:26535713ENST00000361479+11480_8771861.0RegionHistone H3K9me3 binding
HgeneMPHOSPH8chr13:20208101chr13:26535713ENST00000414242+11380_8771868.0RegionHistone H3K9me3 binding
HgeneMPHOSPH8chr13:20208101chr13:26535713ENST00000361479+114600_62971861.0RepeatNote=ANK 1
HgeneMPHOSPH8chr13:20208101chr13:26535713ENST00000361479+114633_66271861.0RepeatNote=ANK 2
HgeneMPHOSPH8chr13:20208101chr13:26535713ENST00000361479+114666_69571861.0RepeatNote=ANK 3
HgeneMPHOSPH8chr13:20208101chr13:26535713ENST00000361479+114699_72871861.0RepeatNote=ANK 4
HgeneMPHOSPH8chr13:20208101chr13:26535713ENST00000414242+113600_62971868.0RepeatNote=ANK 1
HgeneMPHOSPH8chr13:20208101chr13:26535713ENST00000414242+113633_66271868.0RepeatNote=ANK 2
HgeneMPHOSPH8chr13:20208101chr13:26535713ENST00000414242+113666_69571868.0RepeatNote=ANK 3
HgeneMPHOSPH8chr13:20208101chr13:26535713ENST00000414242+113699_72871868.0RepeatNote=ANK 4
TgeneATP8A2chr13:20208101chr13:26535713ENST0000038165532371019_102810611189.0Topological domainCytoplasmic
TgeneATP8A2chr13:20208101chr13:26535713ENST0000038165532371050_106310611189.0Topological domainExtracellular
TgeneATP8A2chr13:20208101chr13:26535713ENST000003816553237116_11910611189.0Topological domainExtracellular
TgeneATP8A2chr13:20208101chr13:26535713ENST000003816553237141_31610611189.0Topological domainCytoplasmic
TgeneATP8A2chr13:20208101chr13:26535713ENST0000038165532371_9410611189.0Topological domainCytoplasmic
TgeneATP8A2chr13:20208101chr13:26535713ENST000003816553237338_36410611189.0Topological domainExtracellular
TgeneATP8A2chr13:20208101chr13:26535713ENST000003816553237386_88710611189.0Topological domainCytoplasmic
TgeneATP8A2chr13:20208101chr13:26535713ENST000003816553237909_91010611189.0Topological domainExtracellular
TgeneATP8A2chr13:20208101chr13:26535713ENST000003816553237932_95910611189.0Topological domainCytoplasmic
TgeneATP8A2chr13:20208101chr13:26535713ENST000003816553237981_99710611189.0Topological domainExtracellular
TgeneATP8A2chr13:20208101chr13:26535713ENST0000038165532371029_104910611189.0TransmembraneHelical
TgeneATP8A2chr13:20208101chr13:26535713ENST000003816553237120_14010611189.0TransmembraneHelical
TgeneATP8A2chr13:20208101chr13:26535713ENST000003816553237317_33710611189.0TransmembraneHelical
TgeneATP8A2chr13:20208101chr13:26535713ENST000003816553237365_38510611189.0TransmembraneHelical
TgeneATP8A2chr13:20208101chr13:26535713ENST000003816553237888_90810611189.0TransmembraneHelical
TgeneATP8A2chr13:20208101chr13:26535713ENST000003816553237911_93110611189.0TransmembraneHelical
TgeneATP8A2chr13:20208101chr13:26535713ENST00000381655323795_11510611189.0TransmembraneHelical
TgeneATP8A2chr13:20208101chr13:26535713ENST000003816553237960_98010611189.0TransmembraneHelical
TgeneATP8A2chr13:20208101chr13:26535713ENST000003816553237998_101810611189.0TransmembraneHelical


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Fusion Gene Sequence for MPHOSPH8-ATP8A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54691_54691_1_MPHOSPH8-ATP8A2_MPHOSPH8_chr13_20208101_ENST00000361479_ATP8A2_chr13_26535713_ENST00000255283_length(transcript)=921nt_BP=281nt
GGAACGCGAGGGGCTGCTGGGGTGTTTGTCGCAGCGGGTTTTCCTCGGCGGTTTGCGGAGCTGCTAGGATGGAGCAGGTTGCGGAGGGAG
CAAGGGTGACCGCAGTCCCTGTGTCAGCTGCCGACAGCACTGAGGAGTTGGCCGAAGTCGAAGAAGGAGTTGGAGTAGTGGGCGAAGATA
ATGACGCAGCCGCGAGAGGAGCGGAGGCCTTTGGCGACAGTGAGGAGGACGGAGAGGATGTGTTCGAGGTGGAGAAGATCCTGGACATGA
AGACCGAGGGGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTCTGGTTCCTACTGCCTGTTTGATTGAAGATGTGG
CATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGCTGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGG
TGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAGACGCCCCCGACGCTGTTCCGGG
GCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACGGAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTT
ATGACACCACCAAAAAGAAATCCAGGAAGAAATAAGACATGAATTTTCCTGACTGATCTTAGGAAAGAGATTCAGTTTGTTGCACCCAGT
GTTAACACATCTTTGTCAGAGAAGACTGGCGTCAGCAGCCAAAACACCAGGAAACACATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGT
TACATATTCCCTCGCAAACCTGGAGTGCAGACCACAGGGGAAGCTATCTTTGCCCTCCCAACTCGTCTGCAGTGCTTAGCCTAACTTTTG
TTTATGTCGTTATGAAGCATT

>54691_54691_1_MPHOSPH8-ATP8A2_MPHOSPH8_chr13_20208101_ENST00000361479_ATP8A2_chr13_26535713_ENST00000255283_length(amino acids)=198AA_BP=71
MEQVAEGARVTAVPVSAADSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDMKTEGATMVLSSAHFWLGLFLVPT
ACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFRGSSLQQGVPHGYAFSQEEHGAVS
QEEVIRAYDTTKKKSRKK

--------------------------------------------------------------
>54691_54691_2_MPHOSPH8-ATP8A2_MPHOSPH8_chr13_20208101_ENST00000361479_ATP8A2_chr13_26535713_ENST00000381655_length(transcript)=6531nt_BP=281nt
GGAACGCGAGGGGCTGCTGGGGTGTTTGTCGCAGCGGGTTTTCCTCGGCGGTTTGCGGAGCTGCTAGGATGGAGCAGGTTGCGGAGGGAG
CAAGGGTGACCGCAGTCCCTGTGTCAGCTGCCGACAGCACTGAGGAGTTGGCCGAAGTCGAAGAAGGAGTTGGAGTAGTGGGCGAAGATA
ATGACGCAGCCGCGAGAGGAGCGGAGGCCTTTGGCGACAGTGAGGAGGACGGAGAGGATGTGTTCGAGGTGGAGAAGATCCTGGACATGA
AGACCGAGGGGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTCTGGTTCCTACTGCCTGTTTGATTGAAGATGTGG
CATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGCTGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGG
TGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAGACGCCCCCGACGCTGTTCCGGG
GCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACGGAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTT
ATGACACCACCAAAAAGAAATCCAGGAAGAAATAAGACATGAATTTTCCTGACTGATCTTAGGAAAGAGATTCAGTTTGTTGCACCCAGT
GTTAACACATCTTTGTCAGAGAAGACTGGCGTCAGCAGCCAAAACACCAGGAAACACATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGT
TACATATTCCCTCGCAAACCTGGAGTGCAGACCACAGGGGAAGCTATCTTTGCCCTCCCAACTCGTCTGCAGTGCTTAGCCTAACTTTTG
TTTATGTCGTTATGAAGCATTCAACTGTGCTCTGTGAGGTGTGAAATTAAAAACATTATGTTTCACCAATATTTAAACATCAGTACTAGT
TGTCCTGGGAGAAAGGGAAAGGAGTTTTATGTTGCGTGAGAGGCCCATCCTGTGTAATTGGAGCAGGGCACACTTGCTTCCTGTTGAGTT
AACTCAGAGGTTAAGTCCAACGGGCCACATGCAGACTTCACTGTAGGCAGGTTGCTCTCCTGCTTTGATTCCTGTTTTGTGTGTAAAATT
GGCATAAACTTCTTGATTGCAGTGAAATCACAAAATTCTCTATCGGGGTGGTCAACCTGAGAACATTTATTTGAACCTCTTAGCCACATT
TCCAGCAGGGCAAACCAACTGATGCCCTGGAAGAGTCTTCCGCACCCTCTCCAGGTGCACTCGGCCCAGTCCTGCCGCCGTGTCCAGGCG
CCCCTCACCCCCACACCTGCTGCATGGCTGGCCACACCACTCAGTGCATGGCGGCCGATGGGCAGCCAACCCAAACCCGCGCCTTTCCTT
GTTCCACTGCAGACTCAGATACAGATGCGAAAAATTCCTTCTTCCACCGCCCTTCTCGTTCTGTAAAGAAAGAAAAGAAACATAGCCTTT
CTGCATATATTCTAAACGTCTCTCTGCCTCTGTCTGACATGGGGCCACCCCACAGGTCAGAGTGGTGGTAGAACCCCTTCAGGACTCCCA
GCCGTGGTCAGGCTCTGAATACTCCCTTCCCAACATCCAGACTGCTGGGCCTTTGGCATCCACTTACATTAGAACCCACGTTTGTTTCAG
AGCACATTTTGGACTTTCACTGTTGGGAAATGAATGAATTTATAACATGCCTGCACAGCGAAGGAACACACCTGTCGCTCTTAGCTCTAG
AGTCAGAGGATGAGTAAACCCAGATGCAAGAGTATAGGACATTGAGTGGGGAGAACAAGACGACCACAGAAGTCCTCAGAAGGAGAAGGA
AGGACACGGAGACACTGAGAGGAGGACACAGAGGAATCGCCACCAGATCTTTGCAGTAGAAACTCTGAAATAGGCCTTGAGACCCAGACA
ATTGTCATGATCAGCCCAGTGTGTATGAGAGCTTAAACAAGACCTTCACACACAGTTCTAATTGAAAAGAATTCCAAACATTTCAGGGAA
ACACCTTTTTAAAAAATATACTGACATGGTTTCCTTTCTGTATCCCATCAGTGTTAGACACAGGTACCTATCAGAATACGGCATATCCTG
AATTATCTAAGACAAGGAAGTGAAGAGCGGAATCACTGACTTTCCCAACTGCAGAGTCCCACACTTAAATCTCAACAGAACCTAGATGTC
TTCAGGCATGAATGTGAGCACCTGGAGCCCTTACTAAACAACCTGCCTGGAGCCCTGTTCTCTGCTCTGGTTGCCAAACCAGATTTTTGG
ATGGCCTAAATACTTGTGGGCAACTGTTACTGGTGAAAAATGGGAGTGGAGAGCATGTTTTGGATTTTCACTGTGGGGAAATGAATGAAT
TTATCACATGACTGTGCAGCGAAGGAGCACACCTGTCACTCTTAGCTCTAGAGTCGGAGGATGAGTCAACCCTGTAGGAATGATTGTGCT
AAATTAGGAAATAACACTTTAGTGCACTTTGCTTCCTAACCCTTTTTTGTCAGAAATCTACAACCTACTGGGCATGGAAATGATTTAAAA
TATGATCTGCATTGACTAAGAAAACTCATCCTCACTTATGAGGTGACCAGGATGCAGAGAGGGCCTGAGGGGCAGCAGAACAATGCAATT
CACAGGTGAGGCTCCAAAAAGGGCCATTTCTTTCTCCCCAAGGTGCATAGAACATTTTTAAATATCAGAGTACCCAGCAAGACGGAAGGA
CTGTCATGCAGGAACTCTAACACAAAATGTGCCTATGACTAACACGACAAACCAAGGTGTATGGTTTCTTTGCACACCCAGAAAGGTGAT
GGCCAAGATACAGAGGAGAAACGAAAACTGGAATTGAATGTGCATTAGGCATCTTAACTATTCATATTTTGTCTCATTTGGGAACTAAGC
CTATTTGGAAAGAGTGGATTAGAAATTGAATTCTTTGTCAAACAGTTAGCTCTGTCTTGAACTTGAAGCCTTCCAAATCAGAATTATGTA
TTTAAGTGTGTGTTTGTGTTTGTTTGGGGTTTTTGTTTCTTACATTAGAGTTCATATTTTCTGGGATTTAAGGATACAGGTGTATTTTCC
TATTCTCTTGAGAAGTAGACTAAACAATATTTGCAGTGATGACAGACGCACACAGAAGAAAACATTAGAAGAGATGCCTTTCTATCCTCT
CATGTGGTTGAGCATTCTTACAGCCAAATGACTAAATTGGCTGTAAATTGGTTTCTAGGAGGAGCAGCTGTCACTACGTGTGATGTATAA
TATTTAGCCAGGGCCAACTCAGGGGCTGTGTCATTTGTCCTATCTTTAAATTGAGGTCAGAGTGTCACACACAACCCCTCCCCTGGGGCA
GGGTGGACTGGACTAGGTTGCATACGCTGGCTGTCAGCTCAGCAAAAATGCCACATGGGGCTTGTCACTCCGCCAGACACTCACTGACTC
ACGGGCTGGCAGGTCACGCTCGGTTAGCGCTCCAGGGCCTGACTCTGGATTGAGCTAAACTGGCAGAATCCACTCAGGCCAACCCTTGGT
CTACTGCTGTGTACAGACAGCCCAGTCCTGTGTTGAGTCTCTCTTCTCCTGGATGACCCTGCAAAAGGAAGAGACCAGTTGTACTGTGGG
CTTAGTTCTGGGTTTCCACTGCACACTGACACGTGCCAGCAAGGGTAGCTGTGGAAAACACGTATCAGGAGAGCAGAGTAGTCTGGATGA
ATACTCTGTGCTGATCAGAACGGGCTCGGTCATAATTTAGGAGTGGAGCTGATGTGTCTGTCCTGCCTCAGTGCAGAATATTCCAGGCTT
CTTGACCAGGGTTATGTTCACCCATCTCCCAACACACACATGCACACATGAAAACAAAAACATGGTAACTCTTTTGGTTCGGCACACCAT
ACAAAACGTGCTTTGGGGCGAGGAGTGCTGTTTCTTTTAACACTTGTAGAGGAATATCCTGAGAAGTGAACCTGGGCTTTGGGAGAGCTC
AGCTGAGAATTCTGTTGACATTTTCTTTCCCTTGACAAGGCTTCAGGTTCGTCTCACTATAGGGAGCTGGCTGTGAAAATCAGTAATAAC
TTGTCAAGAAGCAGTGAAAAATGCGGGGGGGTGGAAAGAGCCTAGGTAACTAATGTCTTATAATGCATATGTATGTAAATATTACAGGAT
TTAAGGTTGAATTTTTTAAAAAGAAAGTTATAGTCTGTAATTTCCATTTGTTATAATAATGACCTTTAATCTTGTCATTTGGAACCATAA
AGCATTTTTATCAGGTACCTCTGTTCCAAGGGATTTATGTCTTAGACCATAGCTGAATTGAATGTTTGCAAAACACTGCTATAGGATAAG
GTGGTCTTTAGTTTTGAACGTGTGAAAGGACTGCACACTTTTCAGCCAGGGTTTGAGTTACTGCCCAGGGTCATCGTCTCAAAGTAATTC
AAGGAGTGATTTAACATCAGCATTTGAAATGTAGTCTTCATCTCCTGGGATCCATAAAAAAATGTGAACAGGGAAATGGTGGCTAAGCAG
AGCCTGAAATAATAACTTGGCAAAGAAATGAGTTTATCAGGTCGAGTCAAAACATGGCATCCCCTGTTACACTCAAGAAATGTTTTCTTC
ATGTAAATGTTTATACGGGCATATATAATCACAATGGGAACAGTTAAAACCCCCTCCCTTCAAAAAAAGAAAATCTATATCAGTTGGGTT
TGGTTTTGGTTCTTCATTGGCTCAAGGCAGTTAACTGTCTCAGTATAGCCTTCGGGGAGATTTAACCTCATTCTAGCCATTTTTCCATCC
TGAAGGCCAAGAAGGACTATTAGAAGGGTTTTTGAGGGGTTTCGGAGGTGAGGGCCCAAGACCCCCATAATGACATCATTAGGCATTCTT
GAAAGGTGTTAACAGACCAGCACGCTCGATGTGTTGTACCCTTCATTTATTTTTTTTTCTCAGCATCCCAAGTTGTCCATCAGTACATTC
CCCTTCACCTTACCTGATCTTCATTTAATGCCCAGTCTGTAACTAATGTTCTGTTTAAAGCTCTCTTAATTTGTTGGCTATGAGTGATTT
GTGAATCTGGGATGTAACCCTGAGTGAGGAGAAAAGGGCATTGAGCCAGCATAAATCTGAATGGGCAGAAGCCACAAACAAATGGGAGCA
GAAAAGAAGGGCGAGCTCCCCCGCGCCGCACCCCGTGTATAATCCAGTGTTAACCTCTGAGGAACACCTCGGCTCTCCCAACTGAGGAGA
GACAAAAGAGGGATTCTTTTTACACCCAGGCTGGCGCATTTTCAAGTGACAATCTCGGGCTCTAGTTGCCTTTGAGATATCCACTCTGCT
CTTTCTCCCAGGCCTCAGACCAAGAAAAACATGCTCTCAAGATTAGCCCATAGGCAGTTCTTGTGACCTGGCTGAAGAAAGAAAGGAGAC
CTGTTTGTTTTAAAAGTCGGGCGCAAAGTGTCAGGTGGCTTTGATTTATGACAGAAAGAGGAAGAAGAAAGTTGGAGTAATAGCACTATC
CAAATAACCCTGCCCAGGAAACTTGGGGGTCAAGAGAGCTTATCAAGAGCCTTTTATAGGTAAGCTCTTCCGTGTGAAAGAGAAAAGGCC
GGAAAGAGGGAGAGAGCCCAGAGAGCAGGCTGCGAACTCACTTCCAATGGGATTGGAGTCTGTTGTATTCTTAAGAGATAGCCTGATATG
TGGTTTATAGGTGAATCAATAAACACCAACAACAACAAAAAAAAAAAAAAAAAAAAAGGAAGAAAAGAAAAAAAGGAAACCAGCCCTGTC
ATGGAATTTCTCTCCTTCCCTGCACAGTAAAGACTTTTGGGTTTTCATGGATAAAATCAATGTCAGTACTGAAACTCCTACTCTCCCCTC
CCGCCCCACTCTCCCCCGTTGCCCGAGATGGCCAAGTTCAGGCCTGTGCAATGCCGCTTCCCTCTGAGCCTCCCTCTCAAGGGCCACGCA
GGCAGCTGCAGCAGGGCCAGCTGCAGGATGGGGCTGCCGGTCACTGAATTGTCGTTCAAATGCATCATCTTTGTGGCGTCTTTCTCATGC
GAGCAAAGCCACGTGCTCTCCTGTCTGCTGTCACATCTGTGCCTGGATTGCTTAAATATTGTTTGTGATGGGGAGGTTTTAATCTGGTGA
TGCAGAGGGAAGCAGGGCTGTGGGGGCACGTTTAATTGGCTCCCAGCAGCGTGGGGGGTGCTTCTATGGTGTGTGGGGTTTTTTGTTGCC
TCCCTCTAGAAGTGTTACCGTTTTCACGTCCTATTAATGTCCTCTGGTTGTTAAATTACAGCAGCACATTACAGTGCACTGGGTTCCCTC
CTGGAGTGAATACAAACGGAGGGCATCTACTTGTATTTTTAGAAGTTTTGGGAGAATTTAGTGATTTGTGGCTTTGATCAATCCTGTTGA
CTGGTGTATGTCTGCGCAAACCTGTTTCAAATAAATCTTTTGTTAAAGTAA

>54691_54691_2_MPHOSPH8-ATP8A2_MPHOSPH8_chr13_20208101_ENST00000361479_ATP8A2_chr13_26535713_ENST00000381655_length(amino acids)=198AA_BP=71
MEQVAEGARVTAVPVSAADSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDMKTEGATMVLSSAHFWLGLFLVPT
ACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFRGSSLQQGVPHGYAFSQEEHGAVS
QEEVIRAYDTTKKKSRKK

--------------------------------------------------------------
>54691_54691_3_MPHOSPH8-ATP8A2_MPHOSPH8_chr13_20208101_ENST00000414242_ATP8A2_chr13_26535713_ENST00000255283_length(transcript)=954nt_BP=314nt
GTTACGCCGCTGATGTGGAGTAGGGCCGAGCGCGGAACGCGAGGGGCTGCTGGGGTGTTTGTCGCAGCGGGTTTTCCTCGGCGGTTTGCG
GAGCTGCTAGGATGGAGCAGGTTGCGGAGGGAGCAAGGGTGACCGCAGTCCCTGTGTCAGCTGCCGACAGCACTGAGGAGTTGGCCGAAG
TCGAAGAAGGAGTTGGAGTAGTGGGCGAAGATAATGACGCAGCCGCGAGAGGAGCGGAGGCCTTTGGCGACAGTGAGGAGGACGGAGAGG
ATGTGTTCGAGGTGGAGAAGATCCTGGACATGAAGACCGAGGGGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTC
TGGTTCCTACTGCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGC
TGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGC
TGGGCCGGAAGACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACG
GAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTTATGACACCACCAAAAAGAAATCCAGGAAGAAATAAGACATGAATTTTCCTGACTGAT
CTTAGGAAAGAGATTCAGTTTGTTGCACCCAGTGTTAACACATCTTTGTCAGAGAAGACTGGCGTCAGCAGCCAAAACACCAGGAAACAC
ATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGTTACATATTCCCTCGCAAACCTGGAGTGCAGACCACAGGGGAAGCTATCTTTGCCCTC
CCAACTCGTCTGCAGTGCTTAGCCTAACTTTTGTTTATGTCGTTATGAAGCATT

>54691_54691_3_MPHOSPH8-ATP8A2_MPHOSPH8_chr13_20208101_ENST00000414242_ATP8A2_chr13_26535713_ENST00000255283_length(amino acids)=198AA_BP=71
MEQVAEGARVTAVPVSAADSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDMKTEGATMVLSSAHFWLGLFLVPT
ACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFRGSSLQQGVPHGYAFSQEEHGAVS
QEEVIRAYDTTKKKSRKK

--------------------------------------------------------------
>54691_54691_4_MPHOSPH8-ATP8A2_MPHOSPH8_chr13_20208101_ENST00000414242_ATP8A2_chr13_26535713_ENST00000381655_length(transcript)=6564nt_BP=314nt
GTTACGCCGCTGATGTGGAGTAGGGCCGAGCGCGGAACGCGAGGGGCTGCTGGGGTGTTTGTCGCAGCGGGTTTTCCTCGGCGGTTTGCG
GAGCTGCTAGGATGGAGCAGGTTGCGGAGGGAGCAAGGGTGACCGCAGTCCCTGTGTCAGCTGCCGACAGCACTGAGGAGTTGGCCGAAG
TCGAAGAAGGAGTTGGAGTAGTGGGCGAAGATAATGACGCAGCCGCGAGAGGAGCGGAGGCCTTTGGCGACAGTGAGGAGGACGGAGAGG
ATGTGTTCGAGGTGGAGAAGATCCTGGACATGAAGACCGAGGGGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTC
TGGTTCCTACTGCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGC
TGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGC
TGGGCCGGAAGACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACG
GAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTTATGACACCACCAAAAAGAAATCCAGGAAGAAATAAGACATGAATTTTCCTGACTGAT
CTTAGGAAAGAGATTCAGTTTGTTGCACCCAGTGTTAACACATCTTTGTCAGAGAAGACTGGCGTCAGCAGCCAAAACACCAGGAAACAC
ATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGTTACATATTCCCTCGCAAACCTGGAGTGCAGACCACAGGGGAAGCTATCTTTGCCCTC
CCAACTCGTCTGCAGTGCTTAGCCTAACTTTTGTTTATGTCGTTATGAAGCATTCAACTGTGCTCTGTGAGGTGTGAAATTAAAAACATT
ATGTTTCACCAATATTTAAACATCAGTACTAGTTGTCCTGGGAGAAAGGGAAAGGAGTTTTATGTTGCGTGAGAGGCCCATCCTGTGTAA
TTGGAGCAGGGCACACTTGCTTCCTGTTGAGTTAACTCAGAGGTTAAGTCCAACGGGCCACATGCAGACTTCACTGTAGGCAGGTTGCTC
TCCTGCTTTGATTCCTGTTTTGTGTGTAAAATTGGCATAAACTTCTTGATTGCAGTGAAATCACAAAATTCTCTATCGGGGTGGTCAACC
TGAGAACATTTATTTGAACCTCTTAGCCACATTTCCAGCAGGGCAAACCAACTGATGCCCTGGAAGAGTCTTCCGCACCCTCTCCAGGTG
CACTCGGCCCAGTCCTGCCGCCGTGTCCAGGCGCCCCTCACCCCCACACCTGCTGCATGGCTGGCCACACCACTCAGTGCATGGCGGCCG
ATGGGCAGCCAACCCAAACCCGCGCCTTTCCTTGTTCCACTGCAGACTCAGATACAGATGCGAAAAATTCCTTCTTCCACCGCCCTTCTC
GTTCTGTAAAGAAAGAAAAGAAACATAGCCTTTCTGCATATATTCTAAACGTCTCTCTGCCTCTGTCTGACATGGGGCCACCCCACAGGT
CAGAGTGGTGGTAGAACCCCTTCAGGACTCCCAGCCGTGGTCAGGCTCTGAATACTCCCTTCCCAACATCCAGACTGCTGGGCCTTTGGC
ATCCACTTACATTAGAACCCACGTTTGTTTCAGAGCACATTTTGGACTTTCACTGTTGGGAAATGAATGAATTTATAACATGCCTGCACA
GCGAAGGAACACACCTGTCGCTCTTAGCTCTAGAGTCAGAGGATGAGTAAACCCAGATGCAAGAGTATAGGACATTGAGTGGGGAGAACA
AGACGACCACAGAAGTCCTCAGAAGGAGAAGGAAGGACACGGAGACACTGAGAGGAGGACACAGAGGAATCGCCACCAGATCTTTGCAGT
AGAAACTCTGAAATAGGCCTTGAGACCCAGACAATTGTCATGATCAGCCCAGTGTGTATGAGAGCTTAAACAAGACCTTCACACACAGTT
CTAATTGAAAAGAATTCCAAACATTTCAGGGAAACACCTTTTTAAAAAATATACTGACATGGTTTCCTTTCTGTATCCCATCAGTGTTAG
ACACAGGTACCTATCAGAATACGGCATATCCTGAATTATCTAAGACAAGGAAGTGAAGAGCGGAATCACTGACTTTCCCAACTGCAGAGT
CCCACACTTAAATCTCAACAGAACCTAGATGTCTTCAGGCATGAATGTGAGCACCTGGAGCCCTTACTAAACAACCTGCCTGGAGCCCTG
TTCTCTGCTCTGGTTGCCAAACCAGATTTTTGGATGGCCTAAATACTTGTGGGCAACTGTTACTGGTGAAAAATGGGAGTGGAGAGCATG
TTTTGGATTTTCACTGTGGGGAAATGAATGAATTTATCACATGACTGTGCAGCGAAGGAGCACACCTGTCACTCTTAGCTCTAGAGTCGG
AGGATGAGTCAACCCTGTAGGAATGATTGTGCTAAATTAGGAAATAACACTTTAGTGCACTTTGCTTCCTAACCCTTTTTTGTCAGAAAT
CTACAACCTACTGGGCATGGAAATGATTTAAAATATGATCTGCATTGACTAAGAAAACTCATCCTCACTTATGAGGTGACCAGGATGCAG
AGAGGGCCTGAGGGGCAGCAGAACAATGCAATTCACAGGTGAGGCTCCAAAAAGGGCCATTTCTTTCTCCCCAAGGTGCATAGAACATTT
TTAAATATCAGAGTACCCAGCAAGACGGAAGGACTGTCATGCAGGAACTCTAACACAAAATGTGCCTATGACTAACACGACAAACCAAGG
TGTATGGTTTCTTTGCACACCCAGAAAGGTGATGGCCAAGATACAGAGGAGAAACGAAAACTGGAATTGAATGTGCATTAGGCATCTTAA
CTATTCATATTTTGTCTCATTTGGGAACTAAGCCTATTTGGAAAGAGTGGATTAGAAATTGAATTCTTTGTCAAACAGTTAGCTCTGTCT
TGAACTTGAAGCCTTCCAAATCAGAATTATGTATTTAAGTGTGTGTTTGTGTTTGTTTGGGGTTTTTGTTTCTTACATTAGAGTTCATAT
TTTCTGGGATTTAAGGATACAGGTGTATTTTCCTATTCTCTTGAGAAGTAGACTAAACAATATTTGCAGTGATGACAGACGCACACAGAA
GAAAACATTAGAAGAGATGCCTTTCTATCCTCTCATGTGGTTGAGCATTCTTACAGCCAAATGACTAAATTGGCTGTAAATTGGTTTCTA
GGAGGAGCAGCTGTCACTACGTGTGATGTATAATATTTAGCCAGGGCCAACTCAGGGGCTGTGTCATTTGTCCTATCTTTAAATTGAGGT
CAGAGTGTCACACACAACCCCTCCCCTGGGGCAGGGTGGACTGGACTAGGTTGCATACGCTGGCTGTCAGCTCAGCAAAAATGCCACATG
GGGCTTGTCACTCCGCCAGACACTCACTGACTCACGGGCTGGCAGGTCACGCTCGGTTAGCGCTCCAGGGCCTGACTCTGGATTGAGCTA
AACTGGCAGAATCCACTCAGGCCAACCCTTGGTCTACTGCTGTGTACAGACAGCCCAGTCCTGTGTTGAGTCTCTCTTCTCCTGGATGAC
CCTGCAAAAGGAAGAGACCAGTTGTACTGTGGGCTTAGTTCTGGGTTTCCACTGCACACTGACACGTGCCAGCAAGGGTAGCTGTGGAAA
ACACGTATCAGGAGAGCAGAGTAGTCTGGATGAATACTCTGTGCTGATCAGAACGGGCTCGGTCATAATTTAGGAGTGGAGCTGATGTGT
CTGTCCTGCCTCAGTGCAGAATATTCCAGGCTTCTTGACCAGGGTTATGTTCACCCATCTCCCAACACACACATGCACACATGAAAACAA
AAACATGGTAACTCTTTTGGTTCGGCACACCATACAAAACGTGCTTTGGGGCGAGGAGTGCTGTTTCTTTTAACACTTGTAGAGGAATAT
CCTGAGAAGTGAACCTGGGCTTTGGGAGAGCTCAGCTGAGAATTCTGTTGACATTTTCTTTCCCTTGACAAGGCTTCAGGTTCGTCTCAC
TATAGGGAGCTGGCTGTGAAAATCAGTAATAACTTGTCAAGAAGCAGTGAAAAATGCGGGGGGGTGGAAAGAGCCTAGGTAACTAATGTC
TTATAATGCATATGTATGTAAATATTACAGGATTTAAGGTTGAATTTTTTAAAAAGAAAGTTATAGTCTGTAATTTCCATTTGTTATAAT
AATGACCTTTAATCTTGTCATTTGGAACCATAAAGCATTTTTATCAGGTACCTCTGTTCCAAGGGATTTATGTCTTAGACCATAGCTGAA
TTGAATGTTTGCAAAACACTGCTATAGGATAAGGTGGTCTTTAGTTTTGAACGTGTGAAAGGACTGCACACTTTTCAGCCAGGGTTTGAG
TTACTGCCCAGGGTCATCGTCTCAAAGTAATTCAAGGAGTGATTTAACATCAGCATTTGAAATGTAGTCTTCATCTCCTGGGATCCATAA
AAAAATGTGAACAGGGAAATGGTGGCTAAGCAGAGCCTGAAATAATAACTTGGCAAAGAAATGAGTTTATCAGGTCGAGTCAAAACATGG
CATCCCCTGTTACACTCAAGAAATGTTTTCTTCATGTAAATGTTTATACGGGCATATATAATCACAATGGGAACAGTTAAAACCCCCTCC
CTTCAAAAAAAGAAAATCTATATCAGTTGGGTTTGGTTTTGGTTCTTCATTGGCTCAAGGCAGTTAACTGTCTCAGTATAGCCTTCGGGG
AGATTTAACCTCATTCTAGCCATTTTTCCATCCTGAAGGCCAAGAAGGACTATTAGAAGGGTTTTTGAGGGGTTTCGGAGGTGAGGGCCC
AAGACCCCCATAATGACATCATTAGGCATTCTTGAAAGGTGTTAACAGACCAGCACGCTCGATGTGTTGTACCCTTCATTTATTTTTTTT
TCTCAGCATCCCAAGTTGTCCATCAGTACATTCCCCTTCACCTTACCTGATCTTCATTTAATGCCCAGTCTGTAACTAATGTTCTGTTTA
AAGCTCTCTTAATTTGTTGGCTATGAGTGATTTGTGAATCTGGGATGTAACCCTGAGTGAGGAGAAAAGGGCATTGAGCCAGCATAAATC
TGAATGGGCAGAAGCCACAAACAAATGGGAGCAGAAAAGAAGGGCGAGCTCCCCCGCGCCGCACCCCGTGTATAATCCAGTGTTAACCTC
TGAGGAACACCTCGGCTCTCCCAACTGAGGAGAGACAAAAGAGGGATTCTTTTTACACCCAGGCTGGCGCATTTTCAAGTGACAATCTCG
GGCTCTAGTTGCCTTTGAGATATCCACTCTGCTCTTTCTCCCAGGCCTCAGACCAAGAAAAACATGCTCTCAAGATTAGCCCATAGGCAG
TTCTTGTGACCTGGCTGAAGAAAGAAAGGAGACCTGTTTGTTTTAAAAGTCGGGCGCAAAGTGTCAGGTGGCTTTGATTTATGACAGAAA
GAGGAAGAAGAAAGTTGGAGTAATAGCACTATCCAAATAACCCTGCCCAGGAAACTTGGGGGTCAAGAGAGCTTATCAAGAGCCTTTTAT
AGGTAAGCTCTTCCGTGTGAAAGAGAAAAGGCCGGAAAGAGGGAGAGAGCCCAGAGAGCAGGCTGCGAACTCACTTCCAATGGGATTGGA
GTCTGTTGTATTCTTAAGAGATAGCCTGATATGTGGTTTATAGGTGAATCAATAAACACCAACAACAACAAAAAAAAAAAAAAAAAAAAA
GGAAGAAAAGAAAAAAAGGAAACCAGCCCTGTCATGGAATTTCTCTCCTTCCCTGCACAGTAAAGACTTTTGGGTTTTCATGGATAAAAT
CAATGTCAGTACTGAAACTCCTACTCTCCCCTCCCGCCCCACTCTCCCCCGTTGCCCGAGATGGCCAAGTTCAGGCCTGTGCAATGCCGC
TTCCCTCTGAGCCTCCCTCTCAAGGGCCACGCAGGCAGCTGCAGCAGGGCCAGCTGCAGGATGGGGCTGCCGGTCACTGAATTGTCGTTC
AAATGCATCATCTTTGTGGCGTCTTTCTCATGCGAGCAAAGCCACGTGCTCTCCTGTCTGCTGTCACATCTGTGCCTGGATTGCTTAAAT
ATTGTTTGTGATGGGGAGGTTTTAATCTGGTGATGCAGAGGGAAGCAGGGCTGTGGGGGCACGTTTAATTGGCTCCCAGCAGCGTGGGGG
GTGCTTCTATGGTGTGTGGGGTTTTTTGTTGCCTCCCTCTAGAAGTGTTACCGTTTTCACGTCCTATTAATGTCCTCTGGTTGTTAAATT
ACAGCAGCACATTACAGTGCACTGGGTTCCCTCCTGGAGTGAATACAAACGGAGGGCATCTACTTGTATTTTTAGAAGTTTTGGGAGAAT
TTAGTGATTTGTGGCTTTGATCAATCCTGTTGACTGGTGTATGTCTGCGCAAACCTGTTTCAAATAAATCTTTTGTTAAAGTAA

>54691_54691_4_MPHOSPH8-ATP8A2_MPHOSPH8_chr13_20208101_ENST00000414242_ATP8A2_chr13_26535713_ENST00000381655_length(amino acids)=198AA_BP=71
MEQVAEGARVTAVPVSAADSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDMKTEGATMVLSSAHFWLGLFLVPT
ACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFRGSSLQQGVPHGYAFSQEEHGAVS
QEEVIRAYDTTKKKSRKK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MPHOSPH8-ATP8A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MPHOSPH8-ATP8A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MPHOSPH8-ATP8A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC3808977CEREBELLAR ATAXIA, MENTAL RETARDATION, AND DYSEQUILIBRIUM SYNDROME 42GENOMICS_ENGLAND;UNIPROT
TgeneC0394006Dysequilibrium syndrome1ORPHANET
TgeneC3714756Intellectual Disability1GENOMICS_ENGLAND