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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GRAMD1C-PHLDB2 (FusionGDB2 ID:HG54762TG90102)

Fusion Gene Summary for GRAMD1C-PHLDB2

check button Fusion gene summary
Fusion gene informationFusion gene name: GRAMD1C-PHLDB2
Fusion gene ID: hg54762tg90102
HgeneTgene
Gene symbol

GRAMD1C

PHLDB2

Gene ID

54762

90102

Gene nameGRAM domain containing 1Cpleckstrin homology like domain family B member 2
Synonyms-LL5b|LL5beta
Cytomap('GRAMD1C')('PHLDB2')

3q13.31

3q13.2

Type of geneprotein-codingprotein-coding
Descriptionprotein Aster-CGRAM domain-containing protein 1Cpleckstrin homology-like domain family B member 2LL5 betaprotein LL5-beta
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000479212, ENST00000358160, 
ENST00000452134, ENST00000440446, 
ENST00000472026, 
Fusion gene scores* DoF score4 X 4 X 3=487 X 7 X 5=245
# samples 47
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRAMD1C [Title/Abstract] AND PHLDB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGRAMD1C(113563496)-PHLDB2(111632165), # samples:1
Anticipated loss of major functional domain due to fusion event.GRAMD1C-PHLDB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GRAMD1C-PHLDB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GRAMD1C-PHLDB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GRAMD1C-PHLDB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GRAMD1C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PHLDB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-HS-A5N8GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+


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Fusion Gene ORF analysis for GRAMD1C-PHLDB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000479212ENST00000393923GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
3UTR-3CDSENST00000479212ENST00000393925GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
3UTR-3CDSENST00000479212ENST00000412622GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
3UTR-3CDSENST00000479212ENST00000431670GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
3UTR-3CDSENST00000479212ENST00000481953GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
3UTR-3CDSENST00000479212ENST00000495180GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
3UTR-intronENST00000479212ENST00000470699GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
3UTR-intronENST00000479212ENST00000477695GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
3UTR-intronENST00000479212ENST00000478922GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
5CDS-intronENST00000358160ENST00000470699GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
5CDS-intronENST00000358160ENST00000477695GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
5CDS-intronENST00000358160ENST00000478922GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
5UTR-3CDSENST00000452134ENST00000393923GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
5UTR-3CDSENST00000452134ENST00000393925GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
5UTR-3CDSENST00000452134ENST00000412622GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
5UTR-3CDSENST00000452134ENST00000431670GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
5UTR-3CDSENST00000452134ENST00000481953GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
5UTR-3CDSENST00000452134ENST00000495180GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
5UTR-intronENST00000452134ENST00000470699GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
5UTR-intronENST00000452134ENST00000477695GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
5UTR-intronENST00000452134ENST00000478922GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
In-frameENST00000358160ENST00000393923GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
In-frameENST00000358160ENST00000393925GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
In-frameENST00000358160ENST00000412622GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
In-frameENST00000358160ENST00000431670GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
In-frameENST00000358160ENST00000481953GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
In-frameENST00000358160ENST00000495180GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-3CDSENST00000440446ENST00000393923GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-3CDSENST00000440446ENST00000393925GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-3CDSENST00000440446ENST00000412622GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-3CDSENST00000440446ENST00000431670GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-3CDSENST00000440446ENST00000481953GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-3CDSENST00000440446ENST00000495180GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-3CDSENST00000472026ENST00000393923GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-3CDSENST00000472026ENST00000393925GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-3CDSENST00000472026ENST00000412622GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-3CDSENST00000472026ENST00000431670GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-3CDSENST00000472026ENST00000481953GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-3CDSENST00000472026ENST00000495180GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-intronENST00000440446ENST00000470699GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-intronENST00000440446ENST00000477695GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-intronENST00000440446ENST00000478922GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-intronENST00000472026ENST00000470699GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-intronENST00000472026ENST00000477695GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+
intron-intronENST00000472026ENST00000478922GRAMD1Cchr3

113563496

+PHLDB2chr3

111632165

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358160GRAMD1Cchr3113563496+ENST00000393923PHLDB2chr3111632165+46686664922963823
ENST00000358160GRAMD1Cchr3113563496+ENST00000412622PHLDB2chr3111632165+49166664922963823
ENST00000358160GRAMD1Cchr3113563496+ENST00000431670PHLDB2chr3111632165+50476664923092866
ENST00000358160GRAMD1Cchr3113563496+ENST00000393925PHLDB2chr3111632165+47776664923092866
ENST00000358160GRAMD1Cchr3113563496+ENST00000481953PHLDB2chr3111632165+46906664922963823
ENST00000358160GRAMD1Cchr3113563496+ENST00000495180PHLDB2chr3111632165+47106664922807771

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358160ENST00000393923GRAMD1Cchr3113563496+PHLDB2chr3111632165+0.0007600060.99924004
ENST00000358160ENST00000412622GRAMD1Cchr3113563496+PHLDB2chr3111632165+0.0007055850.9992944
ENST00000358160ENST00000431670GRAMD1Cchr3113563496+PHLDB2chr3111632165+0.0005302290.9994698
ENST00000358160ENST00000393925GRAMD1Cchr3113563496+PHLDB2chr3111632165+0.0005690890.99943084
ENST00000358160ENST00000481953GRAMD1Cchr3113563496+PHLDB2chr3111632165+0.0007549790.99924505
ENST00000358160ENST00000495180GRAMD1Cchr3113563496+PHLDB2chr3111632165+0.0006835320.99931645

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Fusion Genomic Features for GRAMD1C-PHLDB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GRAMD1Cchr3113563496+PHLDB2chr3111632165+5.99E-060.99999404
GRAMD1Cchr3113563496+PHLDB2chr3111632165+5.99E-060.99999404

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GRAMD1C-PHLDB2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:113563496/chr3:111632165)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePHLDB2chr3:113563496chr3:111632165ENST000003939232181032_10984721238.0Coiled coilOntology_term=ECO:0000255
TgenePHLDB2chr3:113563496chr3:111632165ENST00000393923218584_6964721238.0Coiled coilOntology_term=ECO:0000255
TgenePHLDB2chr3:113563496chr3:111632165ENST00000393923218722_8074721238.0Coiled coilOntology_term=ECO:0000255
TgenePHLDB2chr3:113563496chr3:111632165ENST000003939251181032_10984451254.0Coiled coilOntology_term=ECO:0000255
TgenePHLDB2chr3:113563496chr3:111632165ENST00000393925118584_6964451254.0Coiled coilOntology_term=ECO:0000255
TgenePHLDB2chr3:113563496chr3:111632165ENST00000393925118722_8074451254.0Coiled coilOntology_term=ECO:0000255
TgenePHLDB2chr3:113563496chr3:111632165ENST000004126221171032_10984451211.0Coiled coilOntology_term=ECO:0000255
TgenePHLDB2chr3:113563496chr3:111632165ENST00000412622117584_6964451211.0Coiled coilOntology_term=ECO:0000255
TgenePHLDB2chr3:113563496chr3:111632165ENST00000412622117722_8074451211.0Coiled coilOntology_term=ECO:0000255
TgenePHLDB2chr3:113563496chr3:111632165ENST000004316701181032_10984451254.0Coiled coilOntology_term=ECO:0000255
TgenePHLDB2chr3:113563496chr3:111632165ENST00000431670118584_6964451254.0Coiled coilOntology_term=ECO:0000255
TgenePHLDB2chr3:113563496chr3:111632165ENST00000431670118722_8074451254.0Coiled coilOntology_term=ECO:0000255
TgenePHLDB2chr3:113563496chr3:111632165ENST000004819530161032_10984451211.0Coiled coilOntology_term=ECO:0000255
TgenePHLDB2chr3:113563496chr3:111632165ENST00000481953016584_6964451211.0Coiled coilOntology_term=ECO:0000255
TgenePHLDB2chr3:113563496chr3:111632165ENST00000481953016722_8074451211.0Coiled coilOntology_term=ECO:0000255
TgenePHLDB2chr3:113563496chr3:111632165ENST000003939232181143_12464721238.0DomainPH
TgenePHLDB2chr3:113563496chr3:111632165ENST000003939251181143_12464451254.0DomainPH
TgenePHLDB2chr3:113563496chr3:111632165ENST000004126221171143_12464451211.0DomainPH
TgenePHLDB2chr3:113563496chr3:111632165ENST000004316701181143_12464451254.0DomainPH
TgenePHLDB2chr3:113563496chr3:111632165ENST000004819530161143_12464451211.0DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRAMD1Cchr3:113563496chr3:111632165ENST00000358160+218326_49758663.0DomainVASt
HgeneGRAMD1Cchr3:113563496chr3:111632165ENST00000358160+21869_13658663.0DomainGRAM
HgeneGRAMD1Cchr3:113563496chr3:111632165ENST00000440446+113326_4970458.0DomainVASt
HgeneGRAMD1Cchr3:113563496chr3:111632165ENST00000440446+11369_1360458.0DomainGRAM
HgeneGRAMD1Cchr3:113563496chr3:111632165ENST00000358160+218557_57758663.0TransmembraneHelical
HgeneGRAMD1Cchr3:113563496chr3:111632165ENST00000440446+113557_5770458.0TransmembraneHelical


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Fusion Gene Sequence for GRAMD1C-PHLDB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34586_34586_1_GRAMD1C-PHLDB2_GRAMD1C_chr3_113563496_ENST00000358160_PHLDB2_chr3_111632165_ENST00000393923_length(transcript)=4668nt_BP=666nt
AAAAATTATCCGGGCGTGGTGGCAGGCGCCTGTAACCACAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACTGGGAGGCGGAGG
TTGCAGTTAGCCGAGACGGGGCCTTGGCACTCCATCCAGCCTGAGGAATGAGAGCGAAACTCCGTCTCAAAAAAAAAAAAAAAAAGTTTC
CGAGCAATTCACCTTTTCGCACATTGGGGCAGGGTATGCCATTTCCTGGGAGGCACAGTAGTTTGAGGTTGGGAATAGGGAAGTCTCATT
GTGACCCCTAGAAAGACAAGCCTTCAGGCTAACCCGGTAACACCCATCGTCAGGAATCCTTCACGGCCGCCAGAGGGCGCAAGGAGCTGC
GGCTGGAAGTACTCGGAGGGCCGGCGGAGGAGGCGCGCGGAGCCTGTAACTCGCAGCGCGCGCTGGAGGTGGGCGCGGGGCGGTGCGGTG
CGGTGCGCGCGGGGCGGTGCCGCGGCGGCGGAGGGAGCCGCGATGGAGGGCGCTCCGACTGTCCGTCAGGTGATGAATGAAGGGGATTCA
AGCCTTGCCACCGACTTACAGGAAGATGTAGAGGAAAATCCTAGTCCAACTGTGGAAGAGAATAATGTGGTAGTTAAAAAACAGGGGCCA
AATTTACATAATTGGAGTGGTGACTGGAGCTTTTGGGAGAGACAGCGTCTGGAGACCATCCTCAGTCTCTGTGCTGAATACACAAAGCCT
GACAGTCGCTTATCTACTGGGACCACCGTGGAAGATGTGCAGAAAATCAACAAGGAGCTTGAGAAGCTGCAGCTCTCTGATGAGGAGTCT
GTGTTTGAGGAAGCCCTCATGAGCCCTGACACAAGATACAGGTGCCACCGGAAAGACTCCCTCCCTGATGCAGACTTGGCAAGCTGTGGG
AGTCTCAGTCAGAGCAGTGCCAGCTTCTTTACCCCCAGGAGCACCAGGAATGATGAACTACTCAGTGACCTCACCCGGACTCCTCCACCA
CCATCCTCCACCTTTCCGAAAGCTTCCAGCGAGTCCTCTTATCTAAGTATCCTACCAAAGACCCCAGAGGGTATAAGTGAAGAACAGAGA
TCTCAGGAGTTGGCTGCAATGGAAGAAACCCGGATAGTCATTCTGAACAACCTCGAGGAACTTAAGCAAAAAATCAAAGACATAAATGAT
CAGATGGATGAGTCTTTCAGAGAGTTGGATATGGAATGTGCTCTTTTGGATGGAGAACAGAAATCTGAAACAACTGAACTTATGAAGGAG
AAGGAGATTTTGGATCATCTAAACCGGAAAATAGCTGAACTGGAAAAGAACATTGTTGGTGAAAAGACCAAGGATGCTGACCTGTTGGAT
GTTGAAAGCAAACACTTTGAAGACCTGGAGTTCCAGCAGCTTGAACATGAGAGCCGTCTAGATGAAGAAAAGGAGAACTTGACTCAACAG
CTCCTGCGTGAAGTTGCTGAATATCAACGGAACATCGTTTCTAGAAAGGAAAAAATTTCTGCATTGAAAAAGCAAGCCAATCACATTGTT
CAGCAGGCTCAGAGAGAGCAAGATCATTTTGTGAAAGAAAAGAATAATTTAATAATGATGTTGCAAAGAGAAAAGGAGAATCTTTGTAAT
TTGGAAAAGAAATACTCCAGCCTCTCTGGGGGGAAAGGGTTTCCCGTTAACCCCAATACTTTAAAAGAGGGCTATATCAGTGTAAATGAG
ATTAATGAGCCGTGTGGCAATTCCACGAATCTATCCCCTTCCACTCAGTTTCCTGCTGATGCTGATGCTGTTGCCACTGAGCCTGCCACA
GCTGTGCTGGCGAGCCAGCCACAGAGTAAAGAGCACTTTAGAAGTCTGGAAGAAAGGAAAAAACAGCATAAAGAAGGCCTCTATCTGAGT
GATACTTTGCCTCGAAAGAAAACCACATCTTCCATCTCCCCACATTTCAGCAGTGCTACTATGGGGAGAAGCATCACCCCAAAGGCCCAT
CTGCCCCTAGGACAGAGTAACAGCTGTGGAAGTGTGCTCCCTCCCTCACTGGCAGCCATGGCCAAAGACTCAGAATCTCGGAGGATGCTC
AGAGGTTATAATCACCAACAGATGAGTGAAGGACACAGGCAGAAATCTGAATTTTATAACCGCACAGCATCTGAATCAAATGTCTACTTG
AATAGTTTCCATTATCCAGATCACAGCTACAAGGACCAGGCCTTTGATACTCTGAGCCTCGATAGCTCTGATAGCATGGAGACCAGCATC
TCTGCTTGCTCACCAGACAACATCTCTAGTGCCAGCACTTCAAATATTGCTAGAATAGAAGAAATGGAGAGACTTTTGAAGCAGGCTCAT
GCAGAAAAGACGCGGCTGCTCGAATCCAGGGAACGGGAAATGGAAGCCAAAAAACGAGCCCTGGAAGAAGAAAAACGACGCCGGGAAATC
CTGGAAAAACGATTACAGGAAGAAACTAGCCAGAGGCAGAAGTTAATAGAAAAGGAAGTAAAAATAAGGGAGAGACAAAGGGCACAGGCT
CGTCCTTTGACACGCTACCTGCCTGTCCGGAAGGAAGACTTTGATTTGCGGAGCCATGTAGAGACTGCTGGCCACAATATTGACACCTGT
TACCATGTATCAATCACAGAGAAGACCTGCCGAGGATTCCTCATCAAAATGGGTGGGAAAATTAAAACGTGGAAAAAACGTTGGTTTGTT
TTTGATCGGAACAAGCGAACATTCTCTTATTATGCAGACAAGCATGAAACTAAATTGAAAGGAGTAATATACTTTCAAGCCATTGAAGAA
GTCTATTATGATCACCTCAAGAATGCTAATAAGAGTCCTAATCCGTTACTCACCTTTAGCGTCAAGACTCATGACAGAATCTATTATATG
GTAGCCCCATCGCCAGAAGCCATGCGGATCTGGATGGATGTTATAGTTACGGGGGCAGAAGGTTACACTCACTTCTTGTTGTAGTGAACT
GAGGCAACAGTCCACTTCAGGGCAGACGGCAATAATCTCTTACAAGAATGAAGCCATATTCAACCCCAGATGAGAAAACCCAACAGATCC
ATCCCTTGAGCTGTAAACACTCAGAACTCCTTTCATATCAAGACAAGTTATTTGTAAAAAATAAAGAAGGGGTTTTAATACAAACCTTCA
TAATAAATAGCAAAATAATTGAAGCTTCCATGAGAAAGAAAACACTATTTTGATAAATTGGATCACTTATAGGAACATTTCTAATAAACT
GTTTTTAATCAGTTGTCGGATTTGGTGAAATAAACTAAACAGGTTACAGAATATCTGTATGTACTTGGAAATACAGAATAACTTTATCAC
CCAAATCACTGGCATTGACATTATTGGTAATCAACTGGCTTTTTTTAAAAAAGGTAGCATTTTGTTGACAGTTATTTTGTAAACATAAGC
AAATAAGGGCTTGGAGGGAAATACATTTTAGGAGGAGTTTTGCCTTAATTTTTTAAGTACTGCACCAAAACCAAAGAGCTGACCTGACTT
CTGTGGAACAGTAGTAACTGCAAGTGATGAACTGCATTTCGTATTGTTCTGTATATTTCAAAATGGTATTTTGATGCCATCAAATGCCCA
GGAAATTGACTTTGCAGTGTCACCACTGGTGTAAGCTACTATATATGTATATATATATGTAGTAAACCACTTTTTGTAAAAGAAGAAAGA
GCAAAAAGCTGTGTGTTTTAGAAAAAAAAGCCAGGTTACGCAACAGGCATTCTGTCATGTTGAACAATTTTAAATAAAGAGAATATCTGG
TGTTAGGAGCTTGTTTTGCTGAAGATTTCTCCATTCCTGGTGCTGAGAATAAAGGCAACCAGTAGCCAATGTCCTTTAGATTGTCTGATT
TCTTTTTGTTGTGGAGCACACCTGCTAACTGCTCCCTCAACATAACTATGAAATCATAGCTCTGTTTTCACCAAAGAACAGACCAATTAA
CATACTTATTTGCAGAAGTGGTGTAGTTCTATAAAACGGCAAATGAAGTTCAACTTAATATTCTCTATAATGTATTATTTTATTTTATTT
TTTACAATTAGCCTTTTTTTTAGTTAATTTTTGTCAAATGAAACGACTTCAGGCAAGTCTCTTTTATAATGGTTTTTCAAGTGCCATTTA
TTCTAGTTTATCATGTTTTGCATGTTTGAAAGTATGAATGTGCTCTTTCCTAAAACATGGCAAATGAATAGATGTAGAGAATAACAATAT
TACTTACAAGATGAAATGATTAGATTAGAAGTGTCCCTTTATTAAACTTTGTCAGCCTGACTGGGTACAATTCTTTTGTTAATTTGCAGT
GTGGTTTGTATACACGTATACGTGTTATCAATAATAAGATTTTGCAACTGGATGACACAAGATTTTACTTGAACAGTGAAGGACAAAAAT
CATGATTGTGGAAGATATTTTTAAAATCTGATTTTGCAGCGATCACTTTTAAACCCTGTAGTGATGTAAGACTAAAATATAATTGCTAAG
ATTTTGTTGGTTAATGTAAAGATATGACTTTTCTGCACTGTACTCTCTTCATAGGATTGTAAAGGTGTTCTAATCCAATTGCATGATGTA
GTAAGCCTCTTAAATATGTGTGTTAAATATATTGAGTTTGGATTAAAATGTTGACATGATTTCACATTTGAAAATAAA

>34586_34586_1_GRAMD1C-PHLDB2_GRAMD1C_chr3_113563496_ENST00000358160_PHLDB2_chr3_111632165_ENST00000393923_length(amino acids)=823AA_BP=56
MEGAPTVRQVMNEGDSSLATDLQEDVEENPSPTVEENNVVVKKQGPNLHNWSGDWSFWERQRLETILSLCAEYTKPDSRLSTGTTVEDVQ
KINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSY
LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAEL
EKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEK
NNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFR
SLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQ
KSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREM
EAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFL
IKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDV
IVTGAEGYTHFLL

--------------------------------------------------------------
>34586_34586_2_GRAMD1C-PHLDB2_GRAMD1C_chr3_113563496_ENST00000358160_PHLDB2_chr3_111632165_ENST00000393925_length(transcript)=4777nt_BP=666nt
AAAAATTATCCGGGCGTGGTGGCAGGCGCCTGTAACCACAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACTGGGAGGCGGAGG
TTGCAGTTAGCCGAGACGGGGCCTTGGCACTCCATCCAGCCTGAGGAATGAGAGCGAAACTCCGTCTCAAAAAAAAAAAAAAAAAGTTTC
CGAGCAATTCACCTTTTCGCACATTGGGGCAGGGTATGCCATTTCCTGGGAGGCACAGTAGTTTGAGGTTGGGAATAGGGAAGTCTCATT
GTGACCCCTAGAAAGACAAGCCTTCAGGCTAACCCGGTAACACCCATCGTCAGGAATCCTTCACGGCCGCCAGAGGGCGCAAGGAGCTGC
GGCTGGAAGTACTCGGAGGGCCGGCGGAGGAGGCGCGCGGAGCCTGTAACTCGCAGCGCGCGCTGGAGGTGGGCGCGGGGCGGTGCGGTG
CGGTGCGCGCGGGGCGGTGCCGCGGCGGCGGAGGGAGCCGCGATGGAGGGCGCTCCGACTGTCCGTCAGGTGATGAATGAAGGGGATTCA
AGCCTTGCCACCGACTTACAGGAAGATGTAGAGGAAAATCCTAGTCCAACTGTGGAAGAGAATAATGTGGTAGTTAAAAAACAGGGGCCA
AATTTACATAATTGGAGTGGTGACTGGAGCTTTTGGGAGAGACAGCGTCTGGAGACCATCCTCAGTCTCTGTGCTGAATACACAAAGCCT
GACAGTCGCTTATCTACTGGGACCACCGTGGAAGATGTGCAGAAAATCAACAAGGAGCTTGAGAAGCTGCAGCTCTCTGATGAGGAGTCT
GTGTTTGAGGAAGCCCTCATGAGCCCTGACACAAGATACAGGTGCCACCGGAAAGACTCCCTCCCTGATGCAGACTTGGCAAGCTGTGGG
AGTCTCAGTCAGAGCAGTGCCAGCTTCTTTACCCCCAGGAGCACCAGGAATGATGAACTACTCAGTGACCTCACCCGGACTCCTCCACCA
CCATCCTCCACCTTTCCGAAAGCTTCCAGCGAGTCCTCTTATCTAAGTATCCTACCAAAGACCCCAGAGGGTATAAGTGAAGAACAGAGA
TCTCAGGAGTTGGCTGCAATGGAAGAAACCCGGATAGTCATTCTGAACAACCTCGAGGAACTTAAGCAAAAAATCAAAGACATAAATGAT
CAGATGGATGAGTCTTTCAGAGAGTTGGATATGGAATGTGCTCTTTTGGATGGAGAACAGAAATCTGAAACAACTGAACTTATGAAGGAG
AAGGAGATTTTGGATCATCTAAACCGGAAAATAGCTGAACTGGAAAAGAACATTGTTGGTGAAAAGACCAAGGAGAAGGTAAAGCTTGAT
GCTGAAAGGGAAAAACTAGAGAGGCTTCAGGAGCTTTACTCCGAGCAGAAGACCCAGCTGGACAATTGTCCTGAGTCCATGAGGGAACAG
TTACAACAACAACTGAAGAGGGATGCTGACCTGTTGGATGTTGAAAGCAAACACTTTGAAGACCTGGAGTTCCAGCAGCTTGAACATGAG
AGCCGTCTAGATGAAGAAAAGGAGAACTTGACTCAACAGCTCCTGCGTGAAGTTGCTGAATATCAACGGAACATCGTTTCTAGAAAGGAA
AAAATTTCTGCATTGAAAAAGCAAGCCAATCACATTGTTCAGCAGGCTCAGAGAGAGCAAGATCATTTTGTGAAAGAAAAGAATAATTTA
ATAATGATGTTGCAAAGAGAAAAGGAGAATCTTTGTAATTTGGAAAAGAAATACTCCAGCCTCTCTGGGGGGAAAGGGTTTCCCGTTAAC
CCCAATACTTTAAAAGAGGGCTATATCAGTGTAAATGAGATTAATGAGCCGTGTGGCAATTCCACGAATCTATCCCCTTCCACTCAGTTT
CCTGCTGATGCTGATGCTGTTGCCACTGAGCCTGCCACAGCTGTGCTGGCGAGCCAGCCACAGAGTAAAGAGCACTTTAGAAGTCTGGAA
GAAAGGAAAAAACAGCATAAAGAAGGCCTCTATCTGAGTGATACTTTGCCTCGAAAGAAAACCACATCTTCCATCTCCCCACATTTCAGC
AGTGCTACTATGGGGAGAAGCATCACCCCAAAGGCCCATCTGCCCCTAGGACAGAGTAACAGCTGTGGAAGTGTGCTCCCTCCCTCACTG
GCAGCCATGGCCAAAGACTCAGAATCTCGGAGGATGCTCAGAGGTTATAATCACCAACAGATGAGTGAAGGACACAGGCAGAAATCTGAA
TTTTATAACCGCACAGCATCTGAATCAAATGTCTACTTGAATAGTTTCCATTATCCAGATCACAGCTACAAGGACCAGGCCTTTGATACT
CTGAGCCTCGATAGCTCTGATAGCATGGAGACCAGCATCTCTGCTTGCTCACCAGACAACATCTCTAGTGCCAGCACTTCAAATATTGCT
AGAATAGAAGAAATGGAGAGACTTTTGAAGCAGGCTCATGCAGAAAAGACGCGGCTGCTCGAATCCAGGGAACGGGAAATGGAAGCCAAA
AAACGAGCCCTGGAAGAAGAAAAACGACGCCGGGAAATCCTGGAAAAACGATTACAGGAAGAAACTAGCCAGAGGCAGAAGTTAATAGAA
AAGGAAGTAAAAATAAGGGAGAGACAAAGGGCACAGGCTCGTCCTTTGACACGCTACCTGCCTGTCCGGAAGGAAGACTTTGATTTGCGG
AGCCATGTAGAGACTGCTGGCCACAATATTGACACCTGTTACCATGTATCAATCACAGAGAAGACCTGCCGAGGATTCCTCATCAAAATG
GGTGGGAAAATTAAAACGTGGAAAAAACGTTGGTTTGTTTTTGATCGGAACAAGCGAACATTCTCTTATTATGCAGACAAGCATGAAACT
AAATTGAAAGGAGTAATATACTTTCAAGCCATTGAAGAAGTCTATTATGATCACCTCAAGAATGCTAATAAGAGTCCTAATCCGTTACTC
ACCTTTAGCGTCAAGACTCATGACAGAATCTATTATATGGTAGCCCCATCGCCAGAAGCCATGCGGATCTGGATGGATGTTATAGTTACG
GGGGCAGAAGGTTACACTCACTTCTTGTTGTAGTGAACTGAGGCAACAGTCCACTTCAGGGCAGACGGCAATAATCTCTTACAAGAATGA
AGCCATATTCAACCCCAGATGAGAAAACCCAACAGATCCATCCCTTGAGCTGTAAACACTCAGAACTCCTTTCATATCAAGACAAGTTAT
TTGTAAAAAATAAAGAAGGGGTTTTAATACAAACCTTCATAATAAATAGCAAAATAATTGAAGCTTCCATGAGAAAGAAAACACTATTTT
GATAAATTGGATCACTTATAGGAACATTTCTAATAAACTGTTTTTAATCAGTTGTCGGATTTGGTGAAATAAACTAAACAGGTTACAGAA
TATCTGTATGTACTTGGAAATACAGAATAACTTTATCACCCAAATCACTGGCATTGACATTATTGGTAATCAACTGGCTTTTTTTAAAAA
AGGTAGCATTTTGTTGACAGTTATTTTGTAAACATAAGCAAATAAGGGCTTGGAGGGAAATACATTTTAGGAGGAGTTTTGCCTTAATTT
TTTAAGTACTGCACCAAAACCAAAGAGCTGACCTGACTTCTGTGGAACAGTAGTAACTGCAAGTGATGAACTGCATTTCGTATTGTTCTG
TATATTTCAAAATGGTATTTTGATGCCATCAAATGCCCAGGAAATTGACTTTGCAGTGTCACCACTGGTGTAAGCTACTATATATGTATA
TATATATGTAGTAAACCACTTTTTGTAAAAGAAGAAAGAGCAAAAAGCTGTGTGTTTTAGAAAAAAAAGCCAGGTTACGCAACAGGCATT
CTGTCATGTTGAACAATTTTAAATAAAGAGAATATCTGGTGTTAGGAGCTTGTTTTGCTGAAGATTTCTCCATTCCTGGTGCTGAGAATA
AAGGCAACCAGTAGCCAATGTCCTTTAGATTGTCTGATTTCTTTTTGTTGTGGAGCACACCTGCTAACTGCTCCCTCAACATAACTATGA
AATCATAGCTCTGTTTTCACCAAAGAACAGACCAATTAACATACTTATTTGCAGAAGTGGTGTAGTTCTATAAAACGGCAAATGAAGTTC
AACTTAATATTCTCTATAATGTATTATTTTATTTTATTTTTTACAATTAGCCTTTTTTTTAGTTAATTTTTGTCAAATGAAACGACTTCA
GGCAAGTCTCTTTTATAATGGTTTTTCAAGTGCCATTTATTCTAGTTTATCATGTTTTGCATGTTTGAAAGTATGAATGTGCTCTTTCCT
AAAACATGGCAAATGAATAGATGTAGAGAATAACAATATTACTTACAAGATGAAATGATTAGATTAGAAGTGTCCCTTTATTAAACTTTG
TCAGCCTGACTGGGTACAATTCTTTTGTTAATTTGCAGTGTGGTTTGTATACACGTATACGTGTTATCAATAATAAGATTTTGCAACTGG
ATGACACAAGATTTTACTTGAACAGTGAAGGACAAAAATCATGATTGTGGAAGATATTTTTAAAATCTGATTTTGCAGCGATCACTTTTA
AACCCTGTAGTGATGTAAGACTAAAATATAATTGCTAAGATTTTGTTGGTTAATGTAAAGATATGACTTTTCTGCACTGTACTCTCTTCA
TAGGATTGTAAAGGTGTTCTAATCCAATTGCATGATGTAGTAAGCCTCTTAAATATGTGTGTTAAATATATTGAGTTTGGATTAAAATGT
TGACATG

>34586_34586_2_GRAMD1C-PHLDB2_GRAMD1C_chr3_113563496_ENST00000358160_PHLDB2_chr3_111632165_ENST00000393925_length(amino acids)=866AA_BP=56
MEGAPTVRQVMNEGDSSLATDLQEDVEENPSPTVEENNVVVKKQGPNLHNWSGDWSFWERQRLETILSLCAEYTKPDSRLSTGTTVEDVQ
KINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSY
LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAEL
EKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQL
LREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEI
NEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHL
PLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSIS
ACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQAR
PLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEV
YYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL

--------------------------------------------------------------
>34586_34586_3_GRAMD1C-PHLDB2_GRAMD1C_chr3_113563496_ENST00000358160_PHLDB2_chr3_111632165_ENST00000412622_length(transcript)=4916nt_BP=666nt
AAAAATTATCCGGGCGTGGTGGCAGGCGCCTGTAACCACAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACTGGGAGGCGGAGG
TTGCAGTTAGCCGAGACGGGGCCTTGGCACTCCATCCAGCCTGAGGAATGAGAGCGAAACTCCGTCTCAAAAAAAAAAAAAAAAAGTTTC
CGAGCAATTCACCTTTTCGCACATTGGGGCAGGGTATGCCATTTCCTGGGAGGCACAGTAGTTTGAGGTTGGGAATAGGGAAGTCTCATT
GTGACCCCTAGAAAGACAAGCCTTCAGGCTAACCCGGTAACACCCATCGTCAGGAATCCTTCACGGCCGCCAGAGGGCGCAAGGAGCTGC
GGCTGGAAGTACTCGGAGGGCCGGCGGAGGAGGCGCGCGGAGCCTGTAACTCGCAGCGCGCGCTGGAGGTGGGCGCGGGGCGGTGCGGTG
CGGTGCGCGCGGGGCGGTGCCGCGGCGGCGGAGGGAGCCGCGATGGAGGGCGCTCCGACTGTCCGTCAGGTGATGAATGAAGGGGATTCA
AGCCTTGCCACCGACTTACAGGAAGATGTAGAGGAAAATCCTAGTCCAACTGTGGAAGAGAATAATGTGGTAGTTAAAAAACAGGGGCCA
AATTTACATAATTGGAGTGGTGACTGGAGCTTTTGGGAGAGACAGCGTCTGGAGACCATCCTCAGTCTCTGTGCTGAATACACAAAGCCT
GACAGTCGCTTATCTACTGGGACCACCGTGGAAGATGTGCAGAAAATCAACAAGGAGCTTGAGAAGCTGCAGCTCTCTGATGAGGAGTCT
GTGTTTGAGGAAGCCCTCATGAGCCCTGACACAAGATACAGGTGCCACCGGAAAGACTCCCTCCCTGATGCAGACTTGGCAAGCTGTGGG
AGTCTCAGTCAGAGCAGTGCCAGCTTCTTTACCCCCAGGAGCACCAGGAATGATGAACTACTCAGTGACCTCACCCGGACTCCTCCACCA
CCATCCTCCACCTTTCCGAAAGCTTCCAGCGAGTCCTCTTATCTAAGTATCCTACCAAAGACCCCAGAGGGTATAAGTGAAGAACAGAGA
TCTCAGGAGTTGGCTGCAATGGAAGAAACCCGGATAGTCATTCTGAACAACCTCGAGGAACTTAAGCAAAAAATCAAAGACATAAATGAT
CAGATGGATGAGTCTTTCAGAGAGTTGGATATGGAATGTGCTCTTTTGGATGGAGAACAGAAATCTGAAACAACTGAACTTATGAAGGAG
AAGGAGATTTTGGATCATCTAAACCGGAAAATAGCTGAACTGGAAAAGAACATTGTTGGTGAAAAGACCAAGGATGCTGACCTGTTGGAT
GTTGAAAGCAAACACTTTGAAGACCTGGAGTTCCAGCAGCTTGAACATGAGAGCCGTCTAGATGAAGAAAAGGAGAACTTGACTCAACAG
CTCCTGCGTGAAGTTGCTGAATATCAACGGAACATCGTTTCTAGAAAGGAAAAAATTTCTGCATTGAAAAAGCAAGCCAATCACATTGTT
CAGCAGGCTCAGAGAGAGCAAGATCATTTTGTGAAAGAAAAGAATAATTTAATAATGATGTTGCAAAGAGAAAAGGAGAATCTTTGTAAT
TTGGAAAAGAAATACTCCAGCCTCTCTGGGGGGAAAGGGTTTCCCGTTAACCCCAATACTTTAAAAGAGGGCTATATCAGTGTAAATGAG
ATTAATGAGCCGTGTGGCAATTCCACGAATCTATCCCCTTCCACTCAGTTTCCTGCTGATGCTGATGCTGTTGCCACTGAGCCTGCCACA
GCTGTGCTGGCGAGCCAGCCACAGAGTAAAGAGCACTTTAGAAGTCTGGAAGAAAGGAAAAAACAGCATAAAGAAGGCCTCTATCTGAGT
GATACTTTGCCTCGAAAGAAAACCACATCTTCCATCTCCCCACATTTCAGCAGTGCTACTATGGGGAGAAGCATCACCCCAAAGGCCCAT
CTGCCCCTAGGACAGAGTAACAGCTGTGGAAGTGTGCTCCCTCCCTCACTGGCAGCCATGGCCAAAGACTCAGAATCTCGGAGGATGCTC
AGAGGTTATAATCACCAACAGATGAGTGAAGGACACAGGCAGAAATCTGAATTTTATAACCGCACAGCATCTGAATCAAATGTCTACTTG
AATAGTTTCCATTATCCAGATCACAGCTACAAGGACCAGGCCTTTGATACTCTGAGCCTCGATAGCTCTGATAGCATGGAGACCAGCATC
TCTGCTTGCTCACCAGACAACATCTCTAGTGCCAGCACTTCAAATATTGCTAGAATAGAAGAAATGGAGAGACTTTTGAAGCAGGCTCAT
GCAGAAAAGACGCGGCTGCTCGAATCCAGGGAACGGGAAATGGAAGCCAAAAAACGAGCCCTGGAAGAAGAAAAACGACGCCGGGAAATC
CTGGAAAAACGATTACAGGAAGAAACTAGCCAGAGGCAGAAGTTAATAGAAAAGGAAGTAAAAATAAGGGAGAGACAAAGGGCACAGGCT
CGTCCTTTGACACGCTACCTGCCTGTCCGGAAGGAAGACTTTGATTTGCGGAGCCATGTAGAGACTGCTGGCCACAATATTGACACCTGT
TACCATGTATCAATCACAGAGAAGACCTGCCGAGGATTCCTCATCAAAATGGGTGGGAAAATTAAAACGTGGAAAAAACGTTGGTTTGTT
TTTGATCGGAACAAGCGAACATTCTCTTATTATGCAGACAAGCATGAAACTAAATTGAAAGGAGTAATATACTTTCAAGCCATTGAAGAA
GTCTATTATGATCACCTCAAGAATGCTAATAAGAGTCCTAATCCGTTACTCACCTTTAGCGTCAAGACTCATGACAGAATCTATTATATG
GTAGCCCCATCGCCAGAAGCCATGCGGATCTGGATGGATGTTATAGTTACGGGGGCAGAAGGTTACACTCACTTCTTGTTGTAGTGAACT
GAGGCAACAGTCCACTTCAGGGCAGACGGCAATAATCTCTTACAAGAATGAAGCCATATTCAACCCCAGATGAGAAAACCCAACAGATCC
ATCCCTTGAGCTGTAAACACTCAGAACTCCTTTCATATCAAGACAAGTTATTTGTAAAAAATAAAGAAGGGGTTTTAATACAAACCTTCA
TAATAAATAGCAAAATAATTGAAGCTTCCATGAGAAAGAAAACACTATTTTGATAAATTGGATCACTTATAGGAACATTTCTAATAAACT
GTTTTTAATCAGTTGTCGGATTTGGTGAAATAAACTAAACAGGTTACAGAATATCTGTATGTACTTGGAAATACAGAATAACTTTATCAC
CCAAATCACTGGCATTGACATTATTGGTAATCAACTGGCTTTTTTTAAAAAAGGTAGCATTTTGTTGACAGTTATTTTGTAAACATAAGC
AAATAAGGGCTTGGAGGGAAATACATTTTAGGAGGAGTTTTGCCTTAATTTTTTAAGTACTGCACCAAAACCAAAGAGCTGACCTGACTT
CTGTGGAACAGTAGTAACTGCAAGTGATGAACTGCATTTCGTATTGTTCTGTATATTTCAAAATGGTATTTTGATGCCATCAAATGCCCA
GGAAATTGACTTTGCAGTGTCACCACTGGTGTAAGCTACTATATATGTATATATATATGTAGTAAACCACTTTTTGTAAAAGAAGAAAGA
GCAAAAAGCTGTGTGTTTTAGAAAAAAAAGCCAGGTTACGCAACAGGCATTCTGTCATGTTGAACAATTTTAAATAAAGAGAATATCTGG
TGTTAGGAGCTTGTTTTGCTGAAGATTTCTCCATTCCTGGTGCTGAGAATAAAGGCAACCAGTAGCCAATGTCCTTTAGATTGTCTGATT
TCTTTTTGTTGTGGAGCACACCTGCTAACTGCTCCCTCAACATAACTATGAAATCATAGCTCTGTTTTCACCAAAGAACAGACCAATTAA
CATACTTATTTGCAGAAGTGGTGTAGTTCTATAAAACGGCAAATGAAGTTCAACTTAATATTCTCTATAATGTATTATTTTATTTTATTT
TTTACAATTAGCCTTTTTTTTAGTTAATTTTTGTCAAATGAAACGACTTCAGGCAAGTCTCTTTTATAATGGTTTTTCAAGTGCCATTTA
TTCTAGTTTATCATGTTTTGCATGTTTGAAAGTATGAATGTGCTCTTTCCTAAAACATGGCAAATGAATAGATGTAGAGAATAACAATAT
TACTTACAAGATGAAATGATTAGATTAGAAGTGTCCCTTTATTAAACTTTGTCAGCCTGACTGGGTACAATTCTTTTGTTAATTTGCAGT
GTGGTTTGTATACACGTATACGTGTTATCAATAATAAGATTTTGCAACTGGATGACACAAGATTTTACTTGAACAGTGAAGGACAAAAAT
CATGATTGTGGAAGATATTTTTAAAATCTGATTTTGCAGCGATCACTTTTAAACCCTGTAGTGATGTAAGACTAAAATATAATTGCTAAG
ATTTTGTTGGTTAATGTAAAGATATGACTTTTCTGCACTGTACTCTCTTCATAGGATTGTAAAGGTGTTCTAATCCAATTGCATGATGTA
GTAAGCCTCTTAAATATGTGTGTTAAATATATTGAGTTTGGATTAAAATGTTGACATGATTTCACATTTGAAAATAAACTCATCTCTTAT
TTTGAAGTTACCTATCTGTAGTATGATGGAGGATGAATTAATCGCAAATGACAGTTGTAGAAACTATGTAAAGTTTGTTGTGTGCTAACA
TTATGATTTGTAGTGTATAAACTGAAGTATTCCAATAGAAGTATCTCTGGTTACATCCTATTGCTTACAAAATGAAATGAACCCTGAAAA
ACTCTGACATCATATTGTTGTCTGTTTACACAGATACATTTATTGCTGGGGATTGC

>34586_34586_3_GRAMD1C-PHLDB2_GRAMD1C_chr3_113563496_ENST00000358160_PHLDB2_chr3_111632165_ENST00000412622_length(amino acids)=823AA_BP=56
MEGAPTVRQVMNEGDSSLATDLQEDVEENPSPTVEENNVVVKKQGPNLHNWSGDWSFWERQRLETILSLCAEYTKPDSRLSTGTTVEDVQ
KINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSY
LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAEL
EKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEK
NNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFR
SLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQ
KSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREM
EAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFL
IKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDV
IVTGAEGYTHFLL

--------------------------------------------------------------
>34586_34586_4_GRAMD1C-PHLDB2_GRAMD1C_chr3_113563496_ENST00000358160_PHLDB2_chr3_111632165_ENST00000431670_length(transcript)=5047nt_BP=666nt
AAAAATTATCCGGGCGTGGTGGCAGGCGCCTGTAACCACAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACTGGGAGGCGGAGG
TTGCAGTTAGCCGAGACGGGGCCTTGGCACTCCATCCAGCCTGAGGAATGAGAGCGAAACTCCGTCTCAAAAAAAAAAAAAAAAAGTTTC
CGAGCAATTCACCTTTTCGCACATTGGGGCAGGGTATGCCATTTCCTGGGAGGCACAGTAGTTTGAGGTTGGGAATAGGGAAGTCTCATT
GTGACCCCTAGAAAGACAAGCCTTCAGGCTAACCCGGTAACACCCATCGTCAGGAATCCTTCACGGCCGCCAGAGGGCGCAAGGAGCTGC
GGCTGGAAGTACTCGGAGGGCCGGCGGAGGAGGCGCGCGGAGCCTGTAACTCGCAGCGCGCGCTGGAGGTGGGCGCGGGGCGGTGCGGTG
CGGTGCGCGCGGGGCGGTGCCGCGGCGGCGGAGGGAGCCGCGATGGAGGGCGCTCCGACTGTCCGTCAGGTGATGAATGAAGGGGATTCA
AGCCTTGCCACCGACTTACAGGAAGATGTAGAGGAAAATCCTAGTCCAACTGTGGAAGAGAATAATGTGGTAGTTAAAAAACAGGGGCCA
AATTTACATAATTGGAGTGGTGACTGGAGCTTTTGGGAGAGACAGCGTCTGGAGACCATCCTCAGTCTCTGTGCTGAATACACAAAGCCT
GACAGTCGCTTATCTACTGGGACCACCGTGGAAGATGTGCAGAAAATCAACAAGGAGCTTGAGAAGCTGCAGCTCTCTGATGAGGAGTCT
GTGTTTGAGGAAGCCCTCATGAGCCCTGACACAAGATACAGGTGCCACCGGAAAGACTCCCTCCCTGATGCAGACTTGGCAAGCTGTGGG
AGTCTCAGTCAGAGCAGTGCCAGCTTCTTTACCCCCAGGAGCACCAGGAATGATGAACTACTCAGTGACCTCACCCGGACTCCTCCACCA
CCATCCTCCACCTTTCCGAAAGCTTCCAGCGAGTCCTCTTATCTAAGTATCCTACCAAAGACCCCAGAGGGTATAAGTGAAGAACAGAGA
TCTCAGGAGTTGGCTGCAATGGAAGAAACCCGGATAGTCATTCTGAACAACCTCGAGGAACTTAAGCAAAAAATCAAAGACATAAATGAT
CAGATGGATGAGTCTTTCAGAGAGTTGGATATGGAATGTGCTCTTTTGGATGGAGAACAGAAATCTGAAACAACTGAACTTATGAAGGAG
AAGGAGATTTTGGATCATCTAAACCGGAAAATAGCTGAACTGGAAAAGAACATTGTTGGTGAAAAGACCAAGGAGAAGGTAAAGCTTGAT
GCTGAAAGGGAAAAACTAGAGAGGCTTCAGGAGCTTTACTCCGAGCAGAAGACCCAGCTGGACAATTGTCCTGAGTCCATGAGGGAACAG
TTACAACAACAACTGAAGAGGGATGCTGACCTGTTGGATGTTGAAAGCAAACACTTTGAAGACCTGGAGTTCCAGCAGCTTGAACATGAG
AGCCGTCTAGATGAAGAAAAGGAGAACTTGACTCAACAGCTCCTGCGTGAAGTTGCTGAATATCAACGGAACATCGTTTCTAGAAAGGAA
AAAATTTCTGCATTGAAAAAGCAAGCCAATCACATTGTTCAGCAGGCTCAGAGAGAGCAAGATCATTTTGTGAAAGAAAAGAATAATTTA
ATAATGATGTTGCAAAGAGAAAAGGAGAATCTTTGTAATTTGGAAAAGAAATACTCCAGCCTCTCTGGGGGGAAAGGGTTTCCCGTTAAC
CCCAATACTTTAAAAGAGGGCTATATCAGTGTAAATGAGATTAATGAGCCGTGTGGCAATTCCACGAATCTATCCCCTTCCACTCAGTTT
CCTGCTGATGCTGATGCTGTTGCCACTGAGCCTGCCACAGCTGTGCTGGCGAGCCAGCCACAGAGTAAAGAGCACTTTAGAAGTCTGGAA
GAAAGGAAAAAACAGCATAAAGAAGGCCTCTATCTGAGTGATACTTTGCCTCGAAAGAAAACCACATCTTCCATCTCCCCACATTTCAGC
AGTGCTACTATGGGGAGAAGCATCACCCCAAAGGCCCATCTGCCCCTAGGACAGAGTAACAGCTGTGGAAGTGTGCTCCCTCCCTCACTG
GCAGCCATGGCCAAAGACTCAGAATCTCGGAGGATGCTCAGAGGTTATAATCACCAACAGATGAGTGAAGGACACAGGCAGAAATCTGAA
TTTTATAACCGCACAGCATCTGAATCAAATGTCTACTTGAATAGTTTCCATTATCCAGATCACAGCTACAAGGACCAGGCCTTTGATACT
CTGAGCCTCGATAGCTCTGATAGCATGGAGACCAGCATCTCTGCTTGCTCACCAGACAACATCTCTAGTGCCAGCACTTCAAATATTGCT
AGAATAGAAGAAATGGAGAGACTTTTGAAGCAGGCTCATGCAGAAAAGACGCGGCTGCTCGAATCCAGGGAACGGGAAATGGAAGCCAAA
AAACGAGCCCTGGAAGAAGAAAAACGACGCCGGGAAATCCTGGAAAAACGATTACAGGAAGAAACTAGCCAGAGGCAGAAGTTAATAGAA
AAGGAAGTAAAAATAAGGGAGAGACAAAGGGCACAGGCTCGTCCTTTGACACGCTACCTGCCTGTCCGGAAGGAAGACTTTGATTTGCGG
AGCCATGTAGAGACTGCTGGCCACAATATTGACACCTGTTACCATGTATCAATCACAGAGAAGACCTGCCGAGGATTCCTCATCAAAATG
GGTGGGAAAATTAAAACGTGGAAAAAACGTTGGTTTGTTTTTGATCGGAACAAGCGAACATTCTCTTATTATGCAGACAAGCATGAAACT
AAATTGAAAGGAGTAATATACTTTCAAGCCATTGAAGAAGTCTATTATGATCACCTCAAGAATGCTAATAAGAGTCCTAATCCGTTACTC
ACCTTTAGCGTCAAGACTCATGACAGAATCTATTATATGGTAGCCCCATCGCCAGAAGCCATGCGGATCTGGATGGATGTTATAGTTACG
GGGGCAGAAGGTTACACTCACTTCTTGTTGTAGTGAACTGAGGCAACAGTCCACTTCAGGGCAGACGGCAATAATCTCTTACAAGAATGA
AGCCATATTCAACCCCAGATGAGAAAACCCAACAGATCCATCCCTTGAGCTGTAAACACTCAGAACTCCTTTCATATCAAGACAAGTTAT
TTGTAAAAAATAAAGAAGGGGTTTTAATACAAACCTTCATAATAAATAGCAAAATAATTGAAGCTTCCATGAGAAAGAAAACACTATTTT
GATAAATTGGATCACTTATAGGAACATTTCTAATAAACTGTTTTTAATCAGTTGTCGGATTTGGTGAAATAAACTAAACAGGTTACAGAA
TATCTGTATGTACTTGGAAATACAGAATAACTTTATCACCCAAATCACTGGCATTGACATTATTGGTAATCAACTGGCTTTTTTTAAAAA
AGGTAGCATTTTGTTGACAGTTATTTTGTAAACATAAGCAAATAAGGGCTTGGAGGGAAATACATTTTAGGAGGAGTTTTGCCTTAATTT
TTTAAGTACTGCACCAAAACCAAAGAGCTGACCTGACTTCTGTGGAACAGTAGTAACTGCAAGTGATGAACTGCATTTCGTATTGTTCTG
TATATTTCAAAATGGTATTTTGATGCCATCAAATGCCCAGGAAATTGACTTTGCAGTGTCACCACTGGTGTAAGCTACTATATATGTATA
TATATATGTAGTAAACCACTTTTTGTAAAAGAAGAAAGAGCAAAAAGCTGTGTGTTTTAGAAAAAAAAGCCAGGTTACGCAACAGGCATT
CTGTCATGTTGAACAATTTTAAATAAAGAGAATATCTGGTGTTAGGAGCTTGTTTTGCTGAAGATTTCTCCATTCCTGGTGCTGAGAATA
AAGGCAACCAGTAGCCAATGTCCTTTAGATTGTCTGATTTCTTTTTGTTGTGGAGCACACCTGCTAACTGCTCCCTCAACATAACTATGA
AATCATAGCTCTGTTTTCACCAAAGAACAGACCAATTAACATACTTATTTGCAGAAGTGGTGTAGTTCTATAAAACGGCAAATGAAGTTC
AACTTAATATTCTCTATAATGTATTATTTTATTTTATTTTTTACAATTAGCCTTTTTTTTAGTTAATTTTTGTCAAATGAAACGACTTCA
GGCAAGTCTCTTTTATAATGGTTTTTCAAGTGCCATTTATTCTAGTTTATCATGTTTTGCATGTTTGAAAGTATGAATGTGCTCTTTCCT
AAAACATGGCAAATGAATAGATGTAGAGAATAACAATATTACTTACAAGATGAAATGATTAGATTAGAAGTGTCCCTTTATTAAACTTTG
TCAGCCTGACTGGGTACAATTCTTTTGTTAATTTGCAGTGTGGTTTGTATACACGTATACGTGTTATCAATAATAAGATTTTGCAACTGG
ATGACACAAGATTTTACTTGAACAGTGAAGGACAAAAATCATGATTGTGGAAGATATTTTTAAAATCTGATTTTGCAGCGATCACTTTTA
AACCCTGTAGTGATGTAAGACTAAAATATAATTGCTAAGATTTTGTTGGTTAATGTAAAGATATGACTTTTCTGCACTGTACTCTCTTCA
TAGGATTGTAAAGGTGTTCTAATCCAATTGCATGATGTAGTAAGCCTCTTAAATATGTGTGTTAAATATATTGAGTTTGGATTAAAATGT
TGACATGATTTCACATTTGAAAATAAACTCATCTCTTATTTTGAAGTTACCTATCTGTAGTATGATGGAGGATGAATTAATCGCAAATGA
CAGTTGTAGAAACTATGTAAAGTTTGTTGTGTGCTAACATTATGATTTGTAGTGTATAAACTGAAGTATTCCAATAGAAGTATCTCTGGT
TACATCCTATTGCTTACAAAATGAAATGAACCCTGAAAAACTCTGACATCATATTGTTGTCTGTTTACACAGATACATTTATTGCTGGGG
ATTGCAA

>34586_34586_4_GRAMD1C-PHLDB2_GRAMD1C_chr3_113563496_ENST00000358160_PHLDB2_chr3_111632165_ENST00000431670_length(amino acids)=866AA_BP=56
MEGAPTVRQVMNEGDSSLATDLQEDVEENPSPTVEENNVVVKKQGPNLHNWSGDWSFWERQRLETILSLCAEYTKPDSRLSTGTTVEDVQ
KINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSY
LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAEL
EKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQL
LREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEI
NEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHL
PLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSIS
ACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQAR
PLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEV
YYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL

--------------------------------------------------------------
>34586_34586_5_GRAMD1C-PHLDB2_GRAMD1C_chr3_113563496_ENST00000358160_PHLDB2_chr3_111632165_ENST00000481953_length(transcript)=4690nt_BP=666nt
AAAAATTATCCGGGCGTGGTGGCAGGCGCCTGTAACCACAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACTGGGAGGCGGAGG
TTGCAGTTAGCCGAGACGGGGCCTTGGCACTCCATCCAGCCTGAGGAATGAGAGCGAAACTCCGTCTCAAAAAAAAAAAAAAAAAGTTTC
CGAGCAATTCACCTTTTCGCACATTGGGGCAGGGTATGCCATTTCCTGGGAGGCACAGTAGTTTGAGGTTGGGAATAGGGAAGTCTCATT
GTGACCCCTAGAAAGACAAGCCTTCAGGCTAACCCGGTAACACCCATCGTCAGGAATCCTTCACGGCCGCCAGAGGGCGCAAGGAGCTGC
GGCTGGAAGTACTCGGAGGGCCGGCGGAGGAGGCGCGCGGAGCCTGTAACTCGCAGCGCGCGCTGGAGGTGGGCGCGGGGCGGTGCGGTG
CGGTGCGCGCGGGGCGGTGCCGCGGCGGCGGAGGGAGCCGCGATGGAGGGCGCTCCGACTGTCCGTCAGGTGATGAATGAAGGGGATTCA
AGCCTTGCCACCGACTTACAGGAAGATGTAGAGGAAAATCCTAGTCCAACTGTGGAAGAGAATAATGTGGTAGTTAAAAAACAGGGGCCA
AATTTACATAATTGGAGTGGTGACTGGAGCTTTTGGGAGAGACAGCGTCTGGAGACCATCCTCAGTCTCTGTGCTGAATACACAAAGCCT
GACAGTCGCTTATCTACTGGGACCACCGTGGAAGATGTGCAGAAAATCAACAAGGAGCTTGAGAAGCTGCAGCTCTCTGATGAGGAGTCT
GTGTTTGAGGAAGCCCTCATGAGCCCTGACACAAGATACAGGTGCCACCGGAAAGACTCCCTCCCTGATGCAGACTTGGCAAGCTGTGGG
AGTCTCAGTCAGAGCAGTGCCAGCTTCTTTACCCCCAGGAGCACCAGGAATGATGAACTACTCAGTGACCTCACCCGGACTCCTCCACCA
CCATCCTCCACCTTTCCGAAAGCTTCCAGCGAGTCCTCTTATCTAAGTATCCTACCAAAGACCCCAGAGGGTATAAGTGAAGAACAGAGA
TCTCAGGAGTTGGCTGCAATGGAAGAAACCCGGATAGTCATTCTGAACAACCTCGAGGAACTTAAGCAAAAAATCAAAGACATAAATGAT
CAGATGGATGAGTCTTTCAGAGAGTTGGATATGGAATGTGCTCTTTTGGATGGAGAACAGAAATCTGAAACAACTGAACTTATGAAGGAG
AAGGAGATTTTGGATCATCTAAACCGGAAAATAGCTGAACTGGAAAAGAACATTGTTGGTGAAAAGACCAAGGATGCTGACCTGTTGGAT
GTTGAAAGCAAACACTTTGAAGACCTGGAGTTCCAGCAGCTTGAACATGAGAGCCGTCTAGATGAAGAAAAGGAGAACTTGACTCAACAG
CTCCTGCGTGAAGTTGCTGAATATCAACGGAACATCGTTTCTAGAAAGGAAAAAATTTCTGCATTGAAAAAGCAAGCCAATCACATTGTT
CAGCAGGCTCAGAGAGAGCAAGATCATTTTGTGAAAGAAAAGAATAATTTAATAATGATGTTGCAAAGAGAAAAGGAGAATCTTTGTAAT
TTGGAAAAGAAATACTCCAGCCTCTCTGGGGGGAAAGGGTTTCCCGTTAACCCCAATACTTTAAAAGAGGGCTATATCAGTGTAAATGAG
ATTAATGAGCCGTGTGGCAATTCCACGAATCTATCCCCTTCCACTCAGTTTCCTGCTGATGCTGATGCTGTTGCCACTGAGCCTGCCACA
GCTGTGCTGGCGAGCCAGCCACAGAGTAAAGAGCACTTTAGAAGTCTGGAAGAAAGGAAAAAACAGCATAAAGAAGGCCTCTATCTGAGT
GATACTTTGCCTCGAAAGAAAACCACATCTTCCATCTCCCCACATTTCAGCAGTGCTACTATGGGGAGAAGCATCACCCCAAAGGCCCAT
CTGCCCCTAGGACAGAGTAACAGCTGTGGAAGTGTGCTCCCTCCCTCACTGGCAGCCATGGCCAAAGACTCAGAATCTCGGAGGATGCTC
AGAGGTTATAATCACCAACAGATGAGTGAAGGACACAGGCAGAAATCTGAATTTTATAACCGCACAGCATCTGAATCAAATGTCTACTTG
AATAGTTTCCATTATCCAGATCACAGCTACAAGGACCAGGCCTTTGATACTCTGAGCCTCGATAGCTCTGATAGCATGGAGACCAGCATC
TCTGCTTGCTCACCAGACAACATCTCTAGTGCCAGCACTTCAAATATTGCTAGAATAGAAGAAATGGAGAGACTTTTGAAGCAGGCTCAT
GCAGAAAAGACGCGGCTGCTCGAATCCAGGGAACGGGAAATGGAAGCCAAAAAACGAGCCCTGGAAGAAGAAAAACGACGCCGGGAAATC
CTGGAAAAACGATTACAGGAAGAAACTAGCCAGAGGCAGAAGTTAATAGAAAAGGAAGTAAAAATAAGGGAGAGACAAAGGGCACAGGCT
CGTCCTTTGACACGCTACCTGCCTGTCCGGAAGGAAGACTTTGATTTGCGGAGCCATGTAGAGACTGCTGGCCACAATATTGACACCTGT
TACCATGTATCAATCACAGAGAAGACCTGCCGAGGATTCCTCATCAAAATGGGTGGGAAAATTAAAACGTGGAAAAAACGTTGGTTTGTT
TTTGATCGGAACAAGCGAACATTCTCTTATTATGCAGACAAGCATGAAACTAAATTGAAAGGAGTAATATACTTTCAAGCCATTGAAGAA
GTCTATTATGATCACCTCAAGAATGCTAATAAGAGTCCTAATCCGTTACTCACCTTTAGCGTCAAGACTCATGACAGAATCTATTATATG
GTAGCCCCATCGCCAGAAGCCATGCGGATCTGGATGGATGTTATAGTTACGGGGGCAGAAGGTTACACTCACTTCTTGTTGTAGTGAACT
GAGGCAACAGTCCACTTCAGGGCAGACGGCAATAATCTCTTACAAGAATGAAGCCATATTCAACCCCAGATGAGAAAACCCAACAGATCC
ATCCCTTGAGCTGTAAACACTCAGAACTCCTTTCATATCAAGACAAGTTATTTGTAAAAAATAAAGAAGGGGTTTTAATACAAACCTTCA
TAATAAATAGCAAAATAATTGAAGCTTCCATGAGAAAGAAAACACTATTTTGATAAATTGGATCACTTATAGGAACATTTCTAATAAACT
GTTTTTAATCAGTTGTCGGATTTGGTGAAATAAACTAAACAGGTTACAGAATATCTGTATGTACTTGGAAATACAGAATAACTTTATCAC
CCAAATCACTGGCATTGACATTATTGGTAATCAACTGGCTTTTTTTAAAAAAGGTAGCATTTTGTTGACAGTTATTTTGTAAACATAAGC
AAATAAGGGCTTGGAGGGAAATACATTTTAGGAGGAGTTTTGCCTTAATTTTTTAAGTACTGCACCAAAACCAAAGAGCTGACCTGACTT
CTGTGGAACAGTAGTAACTGCAAGTGATGAACTGCATTTCGTATTGTTCTGTATATTTCAAAATGGTATTTTGATGCCATCAAATGCCCA
GGAAATTGACTTTGCAGTGTCACCACTGGTGTAAGCTACTATATATGTATATATATATGTAGTAAACCACTTTTTGTAAAAGAAGAAAGA
GCAAAAAGCTGTGTGTTTTAGAAAAAAAAGCCAGGTTACGCAACAGGCATTCTGTCATGTTGAACAATTTTAAATAAAGAGAATATCTGG
TGTTAGGAGCTTGTTTTGCTGAAGATTTCTCCATTCCTGGTGCTGAGAATAAAGGCAACCAGTAGCCAATGTCCTTTAGATTGTCTGATT
TCTTTTTGTTGTGGAGCACACCTGCTAACTGCTCCCTCAACATAACTATGAAATCATAGCTCTGTTTTCACCAAAGAACAGACCAATTAA
CATACTTATTTGCAGAAGTGGTGTAGTTCTATAAAACGGCAAATGAAGTTCAACTTAATATTCTCTATAATGTATTATTTTATTTTATTT
TTTACAATTAGCCTTTTTTTTAGTTAATTTTTGTCAAATGAAACGACTTCAGGCAAGTCTCTTTTATAATGGTTTTTCAAGTGCCATTTA
TTCTAGTTTATCATGTTTTGCATGTTTGAAAGTATGAATGTGCTCTTTCCTAAAACATGGCAAATGAATAGATGTAGAGAATAACAATAT
TACTTACAAGATGAAATGATTAGATTAGAAGTGTCCCTTTATTAAACTTTGTCAGCCTGACTGGGTACAATTCTTTTGTTAATTTGCAGT
GTGGTTTGTATACACGTATACGTGTTATCAATAATAAGATTTTGCAACTGGATGACACAAGATTTTACTTGAACAGTGAAGGACAAAAAT
CATGATTGTGGAAGATATTTTTAAAATCTGATTTTGCAGCGATCACTTTTAAACCCTGTAGTGATGTAAGACTAAAATATAATTGCTAAG
ATTTTGTTGGTTAATGTAAAGATATGACTTTTCTGCACTGTACTCTCTTCATAGGATTGTAAAGGTGTTCTAATCCAATTGCATGATGTA
GTAAGCCTCTTAAATATGTGTGTTAAATATATTGAGTTTGGATTAAAATGTTGACATGATTTCACATTTGAAAATAAACTCATCTCTTAT
TTTGAAGTTA

>34586_34586_5_GRAMD1C-PHLDB2_GRAMD1C_chr3_113563496_ENST00000358160_PHLDB2_chr3_111632165_ENST00000481953_length(amino acids)=823AA_BP=56
MEGAPTVRQVMNEGDSSLATDLQEDVEENPSPTVEENNVVVKKQGPNLHNWSGDWSFWERQRLETILSLCAEYTKPDSRLSTGTTVEDVQ
KINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSY
LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAEL
EKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEK
NNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFR
SLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQ
KSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREM
EAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFL
IKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDV
IVTGAEGYTHFLL

--------------------------------------------------------------
>34586_34586_6_GRAMD1C-PHLDB2_GRAMD1C_chr3_113563496_ENST00000358160_PHLDB2_chr3_111632165_ENST00000495180_length(transcript)=4710nt_BP=666nt
AAAAATTATCCGGGCGTGGTGGCAGGCGCCTGTAACCACAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACTGGGAGGCGGAGG
TTGCAGTTAGCCGAGACGGGGCCTTGGCACTCCATCCAGCCTGAGGAATGAGAGCGAAACTCCGTCTCAAAAAAAAAAAAAAAAAGTTTC
CGAGCAATTCACCTTTTCGCACATTGGGGCAGGGTATGCCATTTCCTGGGAGGCACAGTAGTTTGAGGTTGGGAATAGGGAAGTCTCATT
GTGACCCCTAGAAAGACAAGCCTTCAGGCTAACCCGGTAACACCCATCGTCAGGAATCCTTCACGGCCGCCAGAGGGCGCAAGGAGCTGC
GGCTGGAAGTACTCGGAGGGCCGGCGGAGGAGGCGCGCGGAGCCTGTAACTCGCAGCGCGCGCTGGAGGTGGGCGCGGGGCGGTGCGGTG
CGGTGCGCGCGGGGCGGTGCCGCGGCGGCGGAGGGAGCCGCGATGGAGGGCGCTCCGACTGTCCGTCAGGTGATGAATGAAGGGGATTCA
AGCCTTGCCACCGACTTACAGGAAGATGTAGAGGAAAATCCTAGTCCAACTGTGGAAGAGAATAATGTGGTAGTTAAAAAACAGGGGCCA
AATTTACATAATTGGAGTGGTGACTGGAGCTTTTGGGAGAGACAGCGTCTGGAGACCATCCTCAGTCTCTGTGCTGAATACACAAAGCCT
GACAGTCGCTTATCTACTGGGACCACCGTGGAAGATGTGCAGAAAATCAACAAGGAGCTTGAGAAGCTGCAGCTCTCTGATGAGGAGTCT
GTGTTTGAGGAAGCCCTCATGAGCCCTGACACAAGATACAGGTGCCACCGGAAAGACTCCCTCCCTGATGCAGACTTGGCAAGCTGTGGG
AGTCTCAGTCAGAGCAGTGCCAGCTTCTTTACCCCCAGGAGCACCAGGAATGATGAACTACTCAGTGACCTCACCCGGACTCCTCCACCA
CCATCCTCCACCTTTCCGAAAGCTTCCAGCGAGTCCTCTTATCTAAGTATCCTACCAAAGACCCCAGAGGGTATAAGTGAAGAACAGAGA
TCTCAGGAGTTGGCTGCAATGGAAGAAACCCGGATAGTCATTCTGAACAACCTCGAGGAACTTAAGCAAAAAATCAAAGACATAAATGAT
CAGATGGATGAGTCTTTCAGAGAGTTGGATATGGAATGTGCTCTTTTGGATGGAGAACAGAAATCTGAAACAACTGAACTTATGAAGGAG
AAGGAGATTTTGGATCATCTAAACCGGAAAATAGCTGAACTGGAAAAGAACATTGTTGGTGAAAAGACCAAGGAGAAGGTAAAGCTTGAT
GCTGAAAGGGAAAAACTAGAGAGGCTTCAGGAGCTTTACTCCGAGCAGAAGACCCAGCTGGACAATTGTCCTGAGTCCATGAGGGAACAG
TTACAACAACAACTGAAGAGGGATGCTGACCTGTTGGATGTTGAAAGCAAACACTTTGAAGACCTGGAGTTCCAGCAGCTTGAACATGAG
AGCCGTCTAGATGAAGAAAAGGAGAACTTGACTCAACAGCTCCTGCGTGAAGTTGCTGAATATCAACGGAACATCGTTTCTAGAAAGGAA
AAAATTTCTGCATTGAAAAAGCAAGCCAATCACATTGTTCAGCAGGCTCAGAGAGAGCAAGATCATTTTGTGAAAGAAAAGAATAATTTA
ATAATGATGTTGCAAAGAGAAAAGGAGAATCTTTGTAATTTGGAAAAGAAATACTCCAGCCTCTCTGGGGGGAAAGGGTTTCCCGTTAAC
CCCAATACTTTAAAAGAGGCCCATCTGCCCCTAGGACAGAGTAACAGCTGTGGAAGTGTGCTCCCTCCCTCACTGGCAGCCATGGCCAAA
GACTCAGAATCTCGGAGGATGCTCAGAGGTTATAATCACCAACAGATGAGTGAAGGACACAGGCAGAAATCTGAATTTTATAACCGCACA
GCATCTGAATCAAATGTCTACTTGAATAGTTTCCATTATCCAGATCACAGCTACAAGGACCAGGCCTTTGATACTCTGAGCCTCGATAGC
TCTGATAGCATGGAGACCAGCATCTCTGCTTGCTCACCAGACAACATCTCTAGTGCCAGCACTTCAAATATTGCTAGAATAGAAGAAATG
GAGAGACTTTTGAAGCAGGCTCATGCAGAAAAGACGCGGCTGCTCGAATCCAGGGAACGGGAAATGGAAGCCAAAAAACGAGCCCTGGAA
GAAGAAAAACGACGCCGGGAAATCCTGGAAAAACGATTACAGGAAGAAACTAGCCAGAGGCAGAAGTTAATAGAAAAGGAAGTAAAAATA
AGGGAGAGACAAAGGGCACAGGCTCGTCCTTTGACACGCTACCTGCCTGTCCGGAAGGAAGACTTTGATTTGCGGAGCCATGTAGAGACT
GCTGGCCACAATATTGACACCTGTTACCATGTATCAATCACAGAGAAGACCTGCCGAGGATTCCTCATCAAAATGGGTGGGAAAATTAAA
ACGTGGAAAAAACGTTGGTTTGTTTTTGATCGGAACAAGCGAACATTCTCTTATTATGCAGACAAGCATGAAACTAAATTGAAAGGAGTA
ATATACTTTCAAGCCATTGAAGAAGTCTATTATGATCACCTCAAGAATGCTAATAAGAGTCCTAATCCGTTACTCACCTTTAGCGTCAAG
ACTCATGACAGAATCTATTATATGGTAGCCCCATCGCCAGAAGCCATGCGGATCTGGATGGATGTTATAGTTACGGGGGCAGAAGGTTAC
ACTCACTTCTTGTTGTAGTGAACTGAGGCAACAGTCCACTTCAGGGCAGACGGCAATAATCTCTTACAAGAATGAAGCCATATTCAACCC
CAGATGAGAAAACCCAACAGATCCATCCCTTGAGCTGTAAACACTCAGAACTCCTTTCATATCAAGACAAGTTATTTGTAAAAAATAAAG
AAGGGGTTTTAATACAAACCTTCATAATAAATAGCAAAATAATTGAAGCTTCCATGAGAAAGAAAACACTATTTTGATAAATTGGATCAC
TTATAGGAACATTTCTAATAAACTGTTTTTAATCAGTTGTCGGATTTGGTGAAATAAACTAAACAGGTTACAGAATATCTGTATGTACTT
GGAAATACAGAATAACTTTATCACCCAAATCACTGGCATTGACATTATTGGTAATCAACTGGCTTTTTTTAAAAAAGGTAGCATTTTGTT
GACAGTTATTTTGTAAACATAAGCAAATAAGGGCTTGGAGGGAAATACATTTTAGGAGGAGTTTTGCCTTAATTTTTTAAGTACTGCACC
AAAACCAAAGAGCTGACCTGACTTCTGTGGAACAGTAGTAACTGCAAGTGATGAACTGCATTTCGTATTGTTCTGTATATTTCAAAATGG
TATTTTGATGCCATCAAATGCCCAGGAAATTGACTTTGCAGTGTCACCACTGGTGTAAGCTACTATATATGTATATATATATGTAGTAAA
CCACTTTTTGTAAAAGAAGAAAGAGCAAAAAGCTGTGTGTTTTAGAAAAAAAAGCCAGGTTACGCAACAGGCATTCTGTCATGTTGAACA
ATTTTAAATAAAGAGAATATCTGGTGTTAGGAGCTTGTTTTGCTGAAGATTTCTCCATTCCTGGTGCTGAGAATAAAGGCAACCAGTAGC
CAATGTCCTTTAGATTGTCTGATTTCTTTTTGTTGTGGAGCACACCTGCTAACTGCTCCCTCAACATAACTATGAAATCATAGCTCTGTT
TTCACCAAAGAACAGACCAATTAACATACTTATTTGCAGAAGTGGTGTAGTTCTATAAAACGGCAAATGAAGTTCAACTTAATATTCTCT
ATAATGTATTATTTTATTTTATTTTTTACAATTAGCCTTTTTTTTAGTTAATTTTTGTCAAATGAAACGACTTCAGGCAAGTCTCTTTTA
TAATGGTTTTTCAAGTGCCATTTATTCTAGTTTATCATGTTTTGCATGTTTGAAAGTATGAATGTGCTCTTTCCTAAAACATGGCAAATG
AATAGATGTAGAGAATAACAATATTACTTACAAGATGAAATGATTAGATTAGAAGTGTCCCTTTATTAAACTTTGTCAGCCTGACTGGGT
ACAATTCTTTTGTTAATTTGCAGTGTGGTTTGTATACACGTATACGTGTTATCAATAATAAGATTTTGCAACTGGATGACACAAGATTTT
ACTTGAACAGTGAAGGACAAAAATCATGATTGTGGAAGATATTTTTAAAATCTGATTTTGCAGCGATCACTTTTAAACCCTGTAGTGATG
TAAGACTAAAATATAATTGCTAAGATTTTGTTGGTTAATGTAAAGATATGACTTTTCTGCACTGTACTCTCTTCATAGGATTGTAAAGGT
GTTCTAATCCAATTGCATGATGTAGTAAGCCTCTTAAATATGTGTGTTAAATATATTGAGTTTGGATTAAAATGTTGACATGATTTCACA
TTTGAAAATAAACTCATCTCTTATTTTGAAGTTACCTATCTGTAGTATGATGGAGGATGAATTAATCGCAAATGACAGTTGTAGAAACTA
TGTAAAGTTTGTTGTGTGCTAACATTATGATTTGTAGTGTATAAACTGAAGTATTCCAATAGAAGTATCTCTGGTTACATCCTATTGCTT
ACAAAATGAAATGAACCCTGAAAAACTCTG

>34586_34586_6_GRAMD1C-PHLDB2_GRAMD1C_chr3_113563496_ENST00000358160_PHLDB2_chr3_111632165_ENST00000495180_length(amino acids)=771AA_BP=56
MEGAPTVRQVMNEGDSSLATDLQEDVEENPSPTVEENNVVVKKQGPNLHNWSGDWSFWERQRLETILSLCAEYTKPDSRLSTGTTVEDVQ
KINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSY
LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAEL
EKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQL
LREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEAHLPLGQS
NSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPD
NISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRY
LPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHL
KNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GRAMD1C-PHLDB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GRAMD1C-PHLDB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GRAMD1C-PHLDB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0004238Atrial Fibrillation1CTD_human
TgeneC0235480Paroxysmal atrial fibrillation1CTD_human
TgeneC2585653Persistent atrial fibrillation1CTD_human
TgeneC3468561familial atrial fibrillation1CTD_human