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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:DIRAS2-GNA14 (FusionGDB2 ID:HG54769TG9630) |
Fusion Gene Summary for DIRAS2-GNA14 |
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Fusion gene information | Fusion gene name: DIRAS2-GNA14 | Fusion gene ID: hg54769tg9630 | Hgene | Tgene | Gene symbol | DIRAS2 | GNA14 | Gene ID | 54769 | 9630 |
Gene name | DIRAS family GTPase 2 | G protein subunit alpha 14 | |
Synonyms | Di-Ras2 | - | |
Cytomap | ('DIRAS2')('GNA14') 9q22.2 | 9q21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | GTP-binding protein Di-Ras2DIRAS family, GTP-binding RAS-like 2distinct subgroup of the Ras family member 2 | guanine nucleotide-binding protein subunit alpha-14g alpha-14guanine nucleotide binding protein (G protein), alpha 14guanine nucleotide-binding protein 14 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q96HU8 | O95837 | |
Ensembl transtripts involved in fusion gene | ENST00000375765, | ||
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 7 X 4 X 5=140 |
# samples | 4 | 7 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DIRAS2 [Title/Abstract] AND GNA14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | DIRAS2(93405034)-GNA14(80049438), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DIRAS2 | GO:0043406 | positive regulation of MAP kinase activity | 12194967 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BLCA | TCGA-DK-A2I1-01A | DIRAS2 | chr9 | 93405034 | - | GNA14 | chr9 | 80049438 | - |
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Fusion Gene ORF analysis for DIRAS2-GNA14 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000375765 | ENST00000341700 | DIRAS2 | chr9 | 93405034 | - | GNA14 | chr9 | 80049438 | - |
5UTR-intron | ENST00000375765 | ENST00000464095 | DIRAS2 | chr9 | 93405034 | - | GNA14 | chr9 | 80049438 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for DIRAS2-GNA14 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for DIRAS2-GNA14 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:93405034/:80049438) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
DIRAS2 | GNA14 |
FUNCTION: Displays low GTPase activity and exists predominantly in the GTP-bound form. {ECO:0000269|PubMed:12194967}. | FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for DIRAS2-GNA14 |
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Fusion Gene PPI Analysis for DIRAS2-GNA14 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DIRAS2-GNA14 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DIRAS2-GNA14 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human | |
Tgene | C0346073 | Tufted angioma of skin | 1 | GENOMICS_ENGLAND;ORPHANET | |
Tgene | C1367420 | Kaposiform Hemangioendothelioma | 1 | ORPHANET |