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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TET2-CDK14 (FusionGDB2 ID:HG54790TG5218)

Fusion Gene Summary for TET2-CDK14

check button Fusion gene summary
Fusion gene informationFusion gene name: TET2-CDK14
Fusion gene ID: hg54790tg5218
HgeneTgene
Gene symbol

TET2

CDK14

Gene ID

54790

5218

Gene nametet methylcytosine dioxygenase 2cyclin dependent kinase 14
SynonymsKIAA1546|MDSPFTAIRE1|PFTK1
Cytomap('TET2')('CDK14')

4q24

7q21.13

Type of geneprotein-codingprotein-coding
Descriptionmethylcytosine dioxygenase TET2probable methylcytosine dioxygenase TET2tet oncogene family member 2cyclin-dependent kinase 14PFTAIRE protein kinase 1cell division protein kinase 14serine/threonine-protein kinase PFTAIRE-1
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000504042, ENST00000380013, 
ENST00000394764, ENST00000413648, 
ENST00000513237, ENST00000540549, 
ENST00000545826, ENST00000305737, 
Fusion gene scores* DoF score11 X 6 X 11=72622 X 24 X 12=6336
# samples 1532
** MAII scorelog2(15/726*10)=-2.27500704749987
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(32/6336*10)=-4.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TET2 [Title/Abstract] AND CDK14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTET2(106068136)-CDK14(90355881), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTET2

GO:0006211

5-methylcytosine catabolic process

24315485

HgeneTET2

GO:0006493

protein O-linked glycosylation

23222540

HgeneTET2

GO:0080111

DNA demethylation

24315485

TgeneCDK14

GO:0000086

G2/M transition of mitotic cell cycle

20059949

TgeneCDK14

GO:0060828

regulation of canonical Wnt signaling pathway

20059949



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-VS-A8EG-01ATET2chr4

106068136

+CDK14chr7

90355881

+


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Fusion Gene ORF analysis for TET2-CDK14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000504042ENST00000265741TET2chr4

106068136

+CDK14chr7

90355881

+
3UTR-3CDSENST00000504042ENST00000380050TET2chr4

106068136

+CDK14chr7

90355881

+
3UTR-3UTRENST00000504042ENST00000496279TET2chr4

106068136

+CDK14chr7

90355881

+
3UTR-5UTRENST00000504042ENST00000406263TET2chr4

106068136

+CDK14chr7

90355881

+
3UTR-5UTRENST00000504042ENST00000436577TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3CDSENST00000380013ENST00000265741TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3CDSENST00000380013ENST00000380050TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3CDSENST00000394764ENST00000265741TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3CDSENST00000394764ENST00000380050TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3CDSENST00000413648ENST00000265741TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3CDSENST00000413648ENST00000380050TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3CDSENST00000513237ENST00000265741TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3CDSENST00000513237ENST00000380050TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3CDSENST00000540549ENST00000265741TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3CDSENST00000540549ENST00000380050TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3CDSENST00000545826ENST00000265741TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3CDSENST00000545826ENST00000380050TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3UTRENST00000380013ENST00000496279TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3UTRENST00000394764ENST00000496279TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3UTRENST00000413648ENST00000496279TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3UTRENST00000513237ENST00000496279TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3UTRENST00000540549ENST00000496279TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-3UTRENST00000545826ENST00000496279TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-5UTRENST00000380013ENST00000406263TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-5UTRENST00000380013ENST00000436577TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-5UTRENST00000394764ENST00000406263TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-5UTRENST00000394764ENST00000436577TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-5UTRENST00000413648ENST00000406263TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-5UTRENST00000413648ENST00000436577TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-5UTRENST00000513237ENST00000406263TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-5UTRENST00000513237ENST00000436577TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-5UTRENST00000540549ENST00000406263TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-5UTRENST00000540549ENST00000436577TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-5UTRENST00000545826ENST00000406263TET2chr4

106068136

+CDK14chr7

90355881

+
5UTR-5UTRENST00000545826ENST00000436577TET2chr4

106068136

+CDK14chr7

90355881

+
intron-3CDSENST00000305737ENST00000265741TET2chr4

106068136

+CDK14chr7

90355881

+
intron-3CDSENST00000305737ENST00000380050TET2chr4

106068136

+CDK14chr7

90355881

+
intron-3UTRENST00000305737ENST00000496279TET2chr4

106068136

+CDK14chr7

90355881

+
intron-5UTRENST00000305737ENST00000406263TET2chr4

106068136

+CDK14chr7

90355881

+
intron-5UTRENST00000305737ENST00000436577TET2chr4

106068136

+CDK14chr7

90355881

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TET2-CDK14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TET2chr4106068136+CDK14chr790355880+0.107710120.8922899
TET2chr4106068136+CDK14chr790355880+0.107710120.8922899


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TET2-CDK14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:106068136/:90355881)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TET2-CDK14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TET2-CDK14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TET2-CDK14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TET2-CDK14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTET2C0001815Primary Myelofibrosis2ORPHANET
HgeneTET2C0002893Refractory anemias2ORPHANET
HgeneTET2C0002894Refractory anaemia with excess blasts2ORPHANET
HgeneTET2C0026987Myelofibrosis2ORPHANET
HgeneTET2C0040028Thrombocythemia, Essential2ORPHANET
HgeneTET2C0079774Peripheral T-Cell Lymphoma2CTD_human
HgeneTET2C1264195Refractory anemia with ringed sideroblasts2ORPHANET
HgeneTET2C2713368Hematopoetic Myelodysplasia2CTD_human
HgeneTET2C3463824MYELODYSPLASTIC SYNDROME2CGI;CTD_human;GENOMICS_ENGLAND
HgeneTET2C0007134Renal Cell Carcinoma1CTD_human
HgeneTET2C0009402Colorectal Carcinoma1CTD_human
HgeneTET2C0009404Colorectal Neoplasms1CTD_human
HgeneTET2C0020981Angioimmunoblastic Lymphadenopathy1CTD_human
HgeneTET2C0023487Acute Promyelocytic Leukemia1CTD_human
HgeneTET2C0027643Neoplasm Recurrence, Local1CTD_human
HgeneTET2C0032463Polycythemia Vera1ORPHANET
HgeneTET2C0033578Prostatic Neoplasms1CTD_human
HgeneTET2C0036920Sezary Syndrome1CTD_human
HgeneTET2C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneTET2C0376358Malignant neoplasm of prostate1CTD_human
HgeneTET2C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneTET2C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneTET2C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneTET2C1292773Acute myeloid leukemia with multilineage dysplasia1ORPHANET
HgeneTET2C1301365Systemic mastocytosis with associated clonal, hematologic non-mast-cell lineage disease1ORPHANET
HgeneTET2C1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneC2239176Liver carcinoma1CTD_human