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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AFTPH-THRB (FusionGDB2 ID:HG54812TG7068)

Fusion Gene Summary for AFTPH-THRB

check button Fusion gene summary
Fusion gene informationFusion gene name: AFTPH-THRB
Fusion gene ID: hg54812tg7068
HgeneTgene
Gene symbol

AFTPH

THRB

Gene ID

54812

7068

Gene nameaftiphilinthyroid hormone receptor beta
SynonymsNbla10388C-ERBA-2|C-ERBA-BETA|ERBA2|GRTH|NR1A2|PRTH|THR1|THRB1|THRB2
Cytomap('AFTPH')('THRB')

2p14

3p24.2

Type of geneprotein-codingprotein-coding
Descriptionaftiphilinaftiphilin proteinthyroid hormone receptor betanuclear receptor subfamily 1 group A member 2oncogene ERBA2thyroid hormone nuclear receptor beta variant 1thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000238855, ENST00000238856, 
ENST00000409183, ENST00000409933, 
ENST00000422803, ENST00000487769, 
Fusion gene scores* DoF score7 X 6 X 5=2109 X 9 X 4=324
# samples 89
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/324*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AFTPH [Title/Abstract] AND THRB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAFTPH(64812679)-THRB(24193981), # samples:2
Anticipated loss of major functional domain due to fusion event.AFTPH-THRB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AFTPH-THRB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AFTPH-THRB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AFTPH-THRB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AFTPH-THRB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AFTPH-THRB seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AFTPH-THRB seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
AFTPH-THRB seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AFTPH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across THRB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-CJ-5681-01AAFTPHchr2

64812679

-THRBchr3

24193981

-
ChimerDB4KIRCTCGA-CJ-5681-01AAFTPHchr2

64812679

+THRBchr3

24193981

-


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Fusion Gene ORF analysis for AFTPH-THRB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000238855ENST00000280696AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000238855ENST00000356447AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000238855ENST00000396671AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000238855ENST00000416420AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000238856ENST00000280696AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000238856ENST00000356447AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000238856ENST00000396671AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000238856ENST00000416420AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000409183ENST00000280696AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000409183ENST00000356447AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000409183ENST00000396671AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000409183ENST00000416420AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000409933ENST00000280696AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000409933ENST00000356447AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000409933ENST00000396671AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000409933ENST00000416420AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000422803ENST00000280696AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000422803ENST00000356447AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000422803ENST00000396671AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shiftENST00000422803ENST00000416420AFTPHchr2

64812679

+THRBchr3

24193981

-
In-frameENST00000487769ENST00000280696AFTPHchr2

64812679

+THRBchr3

24193981

-
In-frameENST00000487769ENST00000356447AFTPHchr2

64812679

+THRBchr3

24193981

-
In-frameENST00000487769ENST00000396671AFTPHchr2

64812679

+THRBchr3

24193981

-
In-frameENST00000487769ENST00000416420AFTPHchr2

64812679

+THRBchr3

24193981

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000487769AFTPHchr264812679+ENST00000396671THRBchr324193981-760878110171883288
ENST00000487769AFTPHchr264812679+ENST00000356447THRBchr324193981-655478110171883288
ENST00000487769AFTPHchr264812679+ENST00000416420THRBchr324193981-256078110171883288
ENST00000487769AFTPHchr264812679+ENST00000280696THRBchr324193981-193078110171883288

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000487769ENST00000396671AFTPHchr264812679+THRBchr324193981-0.0010143520.9989856
ENST00000487769ENST00000356447AFTPHchr264812679+THRBchr324193981-0.0009072860.9990927
ENST00000487769ENST00000416420AFTPHchr264812679+THRBchr324193981-0.0013386670.9986613
ENST00000487769ENST00000280696AFTPHchr264812679+THRBchr324193981-0.0015400260.99845994

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Fusion Genomic Features for AFTPH-THRB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AFTPH-THRB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:64812679/chr3:24193981)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAFTPHchr2:64812679chr3:24193981ENST00000238855+91028_31887937.0MotifNote=WXXF motif 1
HgeneAFTPHchr2:64812679chr3:24193981ENST00000238855+910432_435887937.0MotifNote=WXXF motif 2
HgeneAFTPHchr2:64812679chr3:24193981ENST00000238855+910436_438887937.0MotifNote=WXXF motif 3 (partial)
HgeneAFTPHchr2:64812679chr3:24193981ENST00000238855+910478_481887937.0MotifNote=WXXF motif 4
HgeneAFTPHchr2:64812679chr3:24193981ENST00000238856+8928_31859910.0MotifNote=WXXF motif 1
HgeneAFTPHchr2:64812679chr3:24193981ENST00000238856+89432_435859910.0MotifNote=WXXF motif 2
HgeneAFTPHchr2:64812679chr3:24193981ENST00000238856+89436_438859910.0MotifNote=WXXF motif 3 (partial)
HgeneAFTPHchr2:64812679chr3:24193981ENST00000238856+89478_481859910.0MotifNote=WXXF motif 4
HgeneAFTPHchr2:64812679chr3:24193981ENST00000409933+8928_31887937.0MotifNote=WXXF motif 1
HgeneAFTPHchr2:64812679chr3:24193981ENST00000409933+89432_435887937.0MotifNote=WXXF motif 2
HgeneAFTPHchr2:64812679chr3:24193981ENST00000409933+89436_438887937.0MotifNote=WXXF motif 3 (partial)
HgeneAFTPHchr2:64812679chr3:24193981ENST00000409933+89478_481887937.0MotifNote=WXXF motif 4
HgeneAFTPHchr2:64812679chr3:24193981ENST00000422803+91028_31887938.0MotifNote=WXXF motif 1
HgeneAFTPHchr2:64812679chr3:24193981ENST00000422803+910432_435887938.0MotifNote=WXXF motif 2
HgeneAFTPHchr2:64812679chr3:24193981ENST00000422803+910436_438887938.0MotifNote=WXXF motif 3 (partial)
HgeneAFTPHchr2:64812679chr3:24193981ENST00000422803+910478_481887938.0MotifNote=WXXF motif 4
HgeneAFTPHchr2:64812679chr3:24193981ENST00000238855+910825_829887937.0RegionClathrin-binding
HgeneAFTPHchr2:64812679chr3:24193981ENST00000238856+89825_829859910.0RegionClathrin-binding
HgeneAFTPHchr2:64812679chr3:24193981ENST00000409933+89825_829887937.0RegionClathrin-binding
HgeneAFTPHchr2:64812679chr3:24193981ENST00000422803+910825_829887938.0RegionClathrin-binding
TgeneTHRBchr2:64812679chr3:24193981ENST0000028069607107_181109477.0DNA bindingNuclear receptor
TgeneTHRBchr2:64812679chr3:24193981ENST00000356447310107_18194462.0DNA bindingNuclear receptor
TgeneTHRBchr2:64812679chr3:24193981ENST00000396671411107_18194462.0DNA bindingNuclear receptor
TgeneTHRBchr2:64812679chr3:24193981ENST00000416420512107_18194462.0DNA bindingNuclear receptor
TgeneTHRBchr2:64812679chr3:24193981ENST0000028069607217_461109477.0DomainNR LBD
TgeneTHRBchr2:64812679chr3:24193981ENST00000356447310217_46194462.0DomainNR LBD
TgeneTHRBchr2:64812679chr3:24193981ENST00000396671411217_46194462.0DomainNR LBD
TgeneTHRBchr2:64812679chr3:24193981ENST00000416420512217_46194462.0DomainNR LBD
TgeneTHRBchr2:64812679chr3:24193981ENST0000028069607107_127109477.0Zinc fingerNR C4-type
TgeneTHRBchr2:64812679chr3:24193981ENST0000028069607145_169109477.0Zinc fingerNR C4-type
TgeneTHRBchr2:64812679chr3:24193981ENST00000356447310107_12794462.0Zinc fingerNR C4-type
TgeneTHRBchr2:64812679chr3:24193981ENST00000356447310145_16994462.0Zinc fingerNR C4-type
TgeneTHRBchr2:64812679chr3:24193981ENST00000396671411107_12794462.0Zinc fingerNR C4-type
TgeneTHRBchr2:64812679chr3:24193981ENST00000396671411145_16994462.0Zinc fingerNR C4-type
TgeneTHRBchr2:64812679chr3:24193981ENST00000416420512107_12794462.0Zinc fingerNR C4-type
TgeneTHRBchr2:64812679chr3:24193981ENST00000416420512145_16994462.0Zinc fingerNR C4-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTHRBchr2:64812679chr3:24193981ENST00000280696071_106109477.0RegionNote=Modulating
TgeneTHRBchr2:64812679chr3:24193981ENST000003564473101_10694462.0RegionNote=Modulating
TgeneTHRBchr2:64812679chr3:24193981ENST000003966714111_10694462.0RegionNote=Modulating
TgeneTHRBchr2:64812679chr3:24193981ENST000004164205121_10694462.0RegionNote=Modulating


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Fusion Gene Sequence for AFTPH-THRB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2753_2753_1_AFTPH-THRB_AFTPH_chr2_64812679_ENST00000487769_THRB_chr3_24193981_ENST00000280696_length(transcript)=1930nt_BP=781nt
TTTCCACATTTTAGTGAACCAGGTGATGACTTTGGAGAATTTGGGGATATAAATGCTGTTTCTTGCCAAGAGGAGACAATATTAACAAAG
TCAGACCTAAAACAGACTTCTGATAATTTATCAGAAGAATGTCAATTGGCAAGAAAATCTAGTGGAACAGGCACTGAACCTGTTGCAAAA
CTTAAAAATGGGCAAGAAGGTGAGATTGGACATTTTGATTCTGTGCCAAATATTCAGGATGACTGCAATGGTTTTCAAGACTCTGATGAT
TTTGCAGACTTCAGTTCAGCTGGTCCTAGCCAAGTTGTAGATTGGAATGCTTTTGAGGATGAACAAAAAGATAGTTGTTCTTGGGCTGCT
TTTGGAGACCAGCAGGCTACTGAATCTCATCATCGAAAGGAAGCCTGGCAGTCACATAGGACAGATGAAAATATTGATACTCCAGGAACC
CCCAAAACGCACAGTGTACCTTCAGCAACTTCCAAAGGAGCAGTTGCTAGTGGCCATTTACAGGAATCAGCCACTTCAGTTCAGGGTATG
TTAGAGCCCACCAAGGAACCACTGAAACCACTTTCTGCTGCAGAAAAAATAGCTTCCATCGGTCAGACAGCCACCATGTCACCAGATATG
AACACATGTACATCTGATCAGTTCCAGGTGTGGATCCGGAGTTGTATGAGTTAACAACTTCTAAGCTGGAAATCTCCACCTCAAGCCTCA
AAGTGACTGATGCATTTGCAAGACTCATGTCTACAGTAGAGAAGACAAGCACATCTACCAGGGTACATCCCCAGTTACTTAGACAAGGAC
GAGCTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACC
ATTCAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGT
CGCTTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAG
AACCGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACT
GTCACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAGCAAAAACGGAAATTCCTGCCAGAAGACATTGGACAAGCACCA
ATAGTCAATGCCCCAGAAGGTGGAAAGGTTGACTTGGAAGCCTTCAGCCATTTTACAAAAATCATCACACCAGCAATTACCAGAGTGGTG
GATTTTGCCAAAAAGTTGCCTATGTTTTGTGAGCTGCCATGTGAAGACCAGATCATCCTCCTCAAAGGCTGCTGCATGGAGATCATGTCC
CTTCGCGCTGCTGTGCGCTATGACCCAGAAAGTGAGACTTTAACCTTGAATGGGGAAATGGCAGTGACACGGGGCCAGCTGAAAAATGGG
GGTCTTGGGGTGGTGTCAGACGCCATCTTTGACCTGGGCATGTCTCTGTCTTCTTTCAACCTGGATGACACTGAAGTAGCCCTCCTTCAG
GCCGTCCTGCTGATGTCTTCAGATCGCCCGGGGCTTGCCTGTGTTGAGAGAATAGAAAAGTACCAAGATAGTTTCCTGCTGGCCTTTGAA
CACTATATCAATTACCGAAAACACCACGTGACACACTTTTGGCCAAAACTCCTGATGAAGGTGACAGATCTGCGGATGATAGGAGCCTGC
CATGCCAGCCGCTTCCTGCACATGAAGGTGGAATGCCCCACAGAACTCTTCCCCCCTTTGTTCTTGGAAGTGTTCGAGGATTAGACTGAC
TGGATTCATTCTCATAATTCCTACAGCACTACTGGGTGTC

>2753_2753_1_AFTPH-THRB_AFTPH_chr2_64812679_ENST00000487769_THRB_chr3_24193981_ENST00000280696_length(amino acids)=288AA_BP=
MATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGK
VDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAI
FDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK
VECPTELFPPLFLEVFED

--------------------------------------------------------------
>2753_2753_2_AFTPH-THRB_AFTPH_chr2_64812679_ENST00000487769_THRB_chr3_24193981_ENST00000356447_length(transcript)=6554nt_BP=781nt
TTTCCACATTTTAGTGAACCAGGTGATGACTTTGGAGAATTTGGGGATATAAATGCTGTTTCTTGCCAAGAGGAGACAATATTAACAAAG
TCAGACCTAAAACAGACTTCTGATAATTTATCAGAAGAATGTCAATTGGCAAGAAAATCTAGTGGAACAGGCACTGAACCTGTTGCAAAA
CTTAAAAATGGGCAAGAAGGTGAGATTGGACATTTTGATTCTGTGCCAAATATTCAGGATGACTGCAATGGTTTTCAAGACTCTGATGAT
TTTGCAGACTTCAGTTCAGCTGGTCCTAGCCAAGTTGTAGATTGGAATGCTTTTGAGGATGAACAAAAAGATAGTTGTTCTTGGGCTGCT
TTTGGAGACCAGCAGGCTACTGAATCTCATCATCGAAAGGAAGCCTGGCAGTCACATAGGACAGATGAAAATATTGATACTCCAGGAACC
CCCAAAACGCACAGTGTACCTTCAGCAACTTCCAAAGGAGCAGTTGCTAGTGGCCATTTACAGGAATCAGCCACTTCAGTTCAGGGTATG
TTAGAGCCCACCAAGGAACCACTGAAACCACTTTCTGCTGCAGAAAAAATAGCTTCCATCGGTCAGACAGCCACCATGTCACCAGATATG
AACACATGTACATCTGATCAGTTCCAGGTGTGGATCCGGAGTTGTATGAGTTAACAACTTCTAAGCTGGAAATCTCCACCTCAAGCCTCA
AAGTGACTGATGCATTTGCAAGACTCATGTCTACAGTAGAGAAGACAAGCACATCTACCAGGGTACATCCCCAGTTACTTAGACAAGGAC
GAGCTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACC
ATTCAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGT
CGCTTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAG
AACCGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACT
GTCACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAGCAAAAACGGAAATTCCTGCCAGAAGACATTGGACAAGCACCA
ATAGTCAATGCCCCAGAAGGTGGAAAGGTTGACTTGGAAGCCTTCAGCCATTTTACAAAAATCATCACACCAGCAATTACCAGAGTGGTG
GATTTTGCCAAAAAGTTGCCTATGTTTTGTGAGCTGCCATGTGAAGACCAGATCATCCTCCTCAAAGGCTGCTGCATGGAGATCATGTCC
CTTCGCGCTGCTGTGCGCTATGACCCAGAAAGTGAGACTTTAACCTTGAATGGGGAAATGGCAGTGACACGGGGCCAGCTGAAAAATGGG
GGTCTTGGGGTGGTGTCAGACGCCATCTTTGACCTGGGCATGTCTCTGTCTTCTTTCAACCTGGATGACACTGAAGTAGCCCTCCTTCAG
GCCGTCCTGCTGATGTCTTCAGATCGCCCGGGGCTTGCCTGTGTTGAGAGAATAGAAAAGTACCAAGATAGTTTCCTGCTGGCCTTTGAA
CACTATATCAATTACCGAAAACACCACGTGACACACTTTTGGCCAAAACTCCTGATGAAGGTGACAGATCTGCGGATGATAGGAGCCTGC
CATGCCAGCCGCTTCCTGCACATGAAGGTGGAATGCCCCACAGAACTCTTCCCCCCTTTGTTCTTGGAAGTGTTCGAGGATTAGACTGAC
TGGATTCATTCTCATAATTCCTACAGCACTACTGGGTGTCATTTCATTCCATTGCCTAGCTCTTTTTTGTTTGTTTCTTTGTGTTGGGAG
GGATTATTTGGGAGGGAAAAGGGAAGTAGTCCTTGGCATAGACATGGATGAAATTGCCCCTTGAATGCGGGTACTTGAAACTATTGCATT
TCGTTCTCCGGTCCTGTGATGTGAATGCTCTGAAGGTTTTATGGTTGTGGAGGTGGGGTGGGGGACAATCATTAACTCACCAGCACCAAG
CATCACCAGCTCCCACCCGTCCCTGGTCCAAGACTTGAGTCAGCAAAATGGCGCCACAGGACACTAAAGAAGCCTTAAAACCAAGATAAT
ACGACCACCTCCACCCAATCCTGATGTTCGCAGGGCTGAAGTTAACAGAGCACAGACCACCTTTAGTTAGATGTGGCTTTCAGCCTTTTA
GGGAAAGACTCGAACAAATTTTCATCTATTCAAGAGCATGCTGTTTGCAGCACTCTTTATGGTCTCCTAGGAGCATAACTTGGAATGTAC
AGGAATATTTGTGTCCTAAAAAAATCAGCTGCCCTTCCAATATCATTTTTATAACGTTATGGTTTAATTCAAGTTATACAAAGGTGTGAC
TCAAGGATGTGCAGGTATTGACTGATGGAGGCCAACAAGGAAAATATTTTTTTTCAGTGAGCCCAGAGAAATTAGAAATCTTCACCAATG
TCAGTGACTGCATGGTTTCCAAAAATTCACATAGTATTACCTCACAGTAGGAAGGCTTCTTTCCCATTTAGGCTCAGAGAACACTTTTAC
AGAAATCAAACCTATTTACAGGGTGGCACCCCTTTTCTGTGGCATCTGATCTGTCATCTCCCAAGCTCCTGAAGTTCTTTATCCAGGTTG
TATCTTTGCTGAGCTGACAACAGATTTCTCTATGGATCAAATATTCTAATCAAGGAAAGATACGGTGAAACTTCAGTCTTCTTCTGGAGA
AATGCTGAGGCGAGATTAGTGCAGCTACATTCTGAGTTGAAGGAAATGCAGTGTTCTGAGGGCCCCTTTGTGTCCTGATGGCTGGAGGAC
GCTTCCTCCTGGTTAGATCCTCAAGCTCCTTGCCTCATTGACAAATGTCTCCTAGTCCCCTTTTTCCCTCTGACTCTGAGGAACTAAATA
GCTTGACTATCTCTAAACAGAGACTGGCCCTGCCACTGACCCTCCTGTCCCTCTCATAGCATACCCTGACAGATACTCAATAGAAAACAC
CTGCAGACCATGTGCACACTTAACTTTCCTGCCCAACCTGCCTCCCCAACGGCCCATGCTAGAATAGCTTGTGCCCAGAAAACAAACAGT
GACACTTCATCTCTTCAGCGTCAGAAAATGGGCATAGAATGTACCCATGCAATTGAATGTATCTCATTCTCCACTGGCATAGTAGATATA
AACTATTCCTTTGCCTACCTTTTACTGCCTTATCCTGGAAATATTGGGGAAAATAAGCCATATCAGTGAGATTTACCTAAAAACAAAGGA
AGGAAAGTCACTATGGAAACCAAGTAGATGCTTTTTGTAAGTTTGGTGGAGCATAACTGGCCCAGAAGTCTGGGTGCCTGAGTTCTAGTT
CGTGCTCTGTCAACTGGTAGATTTGTAATTCTAGGTCTTGGTTTTCTTACCTGGTGAATAAGTCATGATCTCTAAAACCCTTCCTGCCCT
TAATATTGTCTGAATTTCAAGGGGAAAAAAAAAATCTGGTTCCTTTAATTATTTTTTTTTAACACTTAAATTCCTAACTTTATTAGACAA
GAAGTATGGCCCACTTAACAGTTAAGGAACGTAAATTTGTTATTGGCTCGAAATAATAATTTGACACAATACTAGTCAACCATTTAGAGG
CCTTGGAAAAAGAAGAGGAACAGCACTGAAAATTCCAAGTATGATTGGAAATTATCTGGGAGCGGGGAATTAAATATTCAATGCATGAAA
GCAATTGTACTGGCTTCTGGGAAAAAGGAAACAAGAACATTGCTATGGAACTTGTTACCCAGAGAAAGGAAGTGAAAAGATTTACAATTA
TAAGCACGAAATTCATTGGCAGATTACCTGCTTTATCTACAGACAGATTGTTTTGGGGTTTGGTTTTGTCTAGGCAGCCTCTGGCCAGGC
TCCTTAATTGCTTGCTCTGCTAATATTTCAGCTTCCTCTCTTGACTCCTTGAGGAACCAACCGCTCTTTGGAAGACAAACACTTAGCCAC
CTCTGTGCTCCAGGGTAACCCTGAGAAGCTCTGCTGTCTGGGGCAAGCTTTCTTTCCAAAGGGAATGAGAGGAAGGCAAGCAGGCAGGGT
CCTGCAGCGTCAGGCCTTCTGGGGAAAGTTTCCTCATTTTGTTTGACAGGGTCCTCAGTACATCAGACACCCAGATTTGAATATAAGTTC
AGAGCCTGATCTCAAGCTAAATCAGAATGCTTTGGGGACTAACCATGATCGAGAATTGGCCAAATAGTATGGCATATAAACAGCCATCCA
GCCAGCCGCAAGTAAAGGAACGTTTGATCCTTGGCACCTTAAATGATTGATTGCCTTCAATAGGCAAACTGCTGGTCTGGAAATCTCGTT
GAAGGCTGAATACTTCATGCGGAGTAGGACAAGCCTTAGCCCACCTTCAGGTTGAAAGGAAAGGCCATAGGACTCAAAAGATAATGACTC
TGAAACTAAACTCCTTCCTTCTGAAGCTGACAGAGGTACTTAGTGCATCTCAAGACTCCATCTCATAAAACTCATTTGTGAGGGATTTGC
TCTAGATTTTTCTAAACATTTTTTCATCTATTGTCCAGACTTGCAAATCCAGTGTGGACCTGATGGAGATACCCTTCACACCTGCGCTCC
CACCCCCTCGGCAGGGAGACGTCTCAGTAGAGGAGAACACACCCATTATGCTGGGATTTGTATTTATAAATCACTTCCCTTTTAGGGATG
AGCGGTGTGGGGCGTGTGTGCGTGTGAGTGTATGCGCGTGCGTGTGTGACCCTCAAGTGTACTTTGCTCAATTTAGACGTGCAGTATTTC
CAGAAACAATGAAAAAAGTAAGATGTTTTCTTCTTTATGATTCTGCTCAAAACACCACGTGCCGCCTCAGAGCTTTTTCTAGAGCCTCGG
TCCTCAATGACGCGCTTGACCTGTTGATGCCTCAGCCCAGCGAAGCCCCTCACCTGTGCCCCGGGCGACAGCTCTTCAGTGTGCAGTGCA
GGCCTGGGGTGGACTGCCAGGCCTTCGCTCTGTGCCAGCAACGCCGTTCTTGTTGCTCCTCCATGAACAGGGGTACAAGCCCTGGCCCCT
CCTCGACACTAAGCCCCCCACAGACTCAGCCTCCAAGGAACCGCTGAGCACCCTTGAAGCATGTCATTGTCAGTGATACCTTTTTATTCT
ATGGAACTCTAACCTATTCGTGTCATATTGACCTTTTGCTGCATGAGTCATAAATTATGAAATCAGTCTTACAGTTTTTGAAATGTAGCC
AGCATTTGTAAGGCTAAACCTTTTTCATGAACTGAATTTAAGTGAATAACCAAGCCACAGTTCCTCCTCAAATGGAGAGTGATGATCGAC
ATTTGAATCTCTTTGCCCTTTCCAACGGCTATGGCATCAGGTTCTAAAATAAGCTCGTAATTTTTCCTGTTATTTTAATAATATGGAAAT
ATTAGCATAGTGTTTCTTTTGATAGTGATAGACTATAATCCATATTTAAATTTTATAGAGAAGAAATTTTATTGTACTGTGATGTAGATA
TTTATTATCCAGGTAAGGATTTGCCCGGTGTGTATTTTTTACAATTGAGACATTTTACTTTAATCTTTAAAAAAAATGCATTAAAAACAC
ACTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACCAGACTGGGGGAAAAAAGGTTTGGCCTTATCACAGAATTTTTACTGTGCTGTATA
AATGTTTGCAAATGCGAAAAGTGTGCATTTATAGTGTGTTTCCACATTAATTAATGCCGCCTTCAAGAGCAATATTGTGCAGGTAAAACG
CTGTTTGTGGCTTTCTGTTGCACAGTTAAAGCTGACCCACCCTATGCACAAGACAATCAAATATAAATCTGTCCTCCTCAGGATGCAGAT
AATACTCATGTAAATTATGGAGCACAATGTAAGACAAAAGGAGACACTTTACATATGTATTGTTGATACAGAAATTATCAGGGCATGAAT
GAGCTGATGTGACATTATGCCACTTCTTTCTTTTGGTTCTCCCTTATTAACTTGGCATTTTTAATTTGACCATAGAGCCAAATTAGTTCT
CCATGCTTTCTTCGTAGAAAATCCTTTTTTTTCCCATAATGTTTTCATGCCCTGAGAATCAGAAAAATACTACAGAATAGAAAAAGATTT
ACAGTCATTGGAAGATTTGTGTTTTGCAAACAGTGTTAAGTGATATTGCTAGATGGTGATATTTTTTTCAGCCTAAAACTCTGTTGAAAT
CTGTGATCAAAATGTTTTAAACTATCCAAAAAAAATTTGTATATTTGGGAAAAATGGATTTTTACATAGCTTTTGTATGCAGATATAAAA
CTGTAATTATGAATATAGTGGGCGTAGATAAACTCATAAGCTTAAATTCTAAAAAAGAAAAAGCTTATAACAGA

>2753_2753_2_AFTPH-THRB_AFTPH_chr2_64812679_ENST00000487769_THRB_chr3_24193981_ENST00000356447_length(amino acids)=288AA_BP=
MATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGK
VDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAI
FDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK
VECPTELFPPLFLEVFED

--------------------------------------------------------------
>2753_2753_3_AFTPH-THRB_AFTPH_chr2_64812679_ENST00000487769_THRB_chr3_24193981_ENST00000396671_length(transcript)=7608nt_BP=781nt
TTTCCACATTTTAGTGAACCAGGTGATGACTTTGGAGAATTTGGGGATATAAATGCTGTTTCTTGCCAAGAGGAGACAATATTAACAAAG
TCAGACCTAAAACAGACTTCTGATAATTTATCAGAAGAATGTCAATTGGCAAGAAAATCTAGTGGAACAGGCACTGAACCTGTTGCAAAA
CTTAAAAATGGGCAAGAAGGTGAGATTGGACATTTTGATTCTGTGCCAAATATTCAGGATGACTGCAATGGTTTTCAAGACTCTGATGAT
TTTGCAGACTTCAGTTCAGCTGGTCCTAGCCAAGTTGTAGATTGGAATGCTTTTGAGGATGAACAAAAAGATAGTTGTTCTTGGGCTGCT
TTTGGAGACCAGCAGGCTACTGAATCTCATCATCGAAAGGAAGCCTGGCAGTCACATAGGACAGATGAAAATATTGATACTCCAGGAACC
CCCAAAACGCACAGTGTACCTTCAGCAACTTCCAAAGGAGCAGTTGCTAGTGGCCATTTACAGGAATCAGCCACTTCAGTTCAGGGTATG
TTAGAGCCCACCAAGGAACCACTGAAACCACTTTCTGCTGCAGAAAAAATAGCTTCCATCGGTCAGACAGCCACCATGTCACCAGATATG
AACACATGTACATCTGATCAGTTCCAGGTGTGGATCCGGAGTTGTATGAGTTAACAACTTCTAAGCTGGAAATCTCCACCTCAAGCCTCA
AAGTGACTGATGCATTTGCAAGACTCATGTCTACAGTAGAGAAGACAAGCACATCTACCAGGGTACATCCCCAGTTACTTAGACAAGGAC
GAGCTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACC
ATTCAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGT
CGCTTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAG
AACCGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACT
GTCACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAGCAAAAACGGAAATTCCTGCCAGAAGACATTGGACAAGCACCA
ATAGTCAATGCCCCAGAAGGTGGAAAGGTTGACTTGGAAGCCTTCAGCCATTTTACAAAAATCATCACACCAGCAATTACCAGAGTGGTG
GATTTTGCCAAAAAGTTGCCTATGTTTTGTGAGCTGCCATGTGAAGACCAGATCATCCTCCTCAAAGGCTGCTGCATGGAGATCATGTCC
CTTCGCGCTGCTGTGCGCTATGACCCAGAAAGTGAGACTTTAACCTTGAATGGGGAAATGGCAGTGACACGGGGCCAGCTGAAAAATGGG
GGTCTTGGGGTGGTGTCAGACGCCATCTTTGACCTGGGCATGTCTCTGTCTTCTTTCAACCTGGATGACACTGAAGTAGCCCTCCTTCAG
GCCGTCCTGCTGATGTCTTCAGATCGCCCGGGGCTTGCCTGTGTTGAGAGAATAGAAAAGTACCAAGATAGTTTCCTGCTGGCCTTTGAA
CACTATATCAATTACCGAAAACACCACGTGACACACTTTTGGCCAAAACTCCTGATGAAGGTGACAGATCTGCGGATGATAGGAGCCTGC
CATGCCAGCCGCTTCCTGCACATGAAGGTGGAATGCCCCACAGAACTCTTCCCCCCTTTGTTCTTGGAAGTGTTCGAGGATTAGACTGAC
TGGATTCATTCTCATAATTCCTACAGCACTACTGGGTGTCATTTCATTCCATTGCCTAGCTCTTTTTTGTTTGTTTCTTTGTGTTGGGAG
GGATTATTTGGGAGGGAAAAGGGAAGTAGTCCTTGGCATAGACATGGATGAAATTGCCCCTTGAATGCGGGTACTTGAAACTATTGCATT
TCGTTCTCCGGTCCTGTGATGTGAATGCTCTGAAGGTTTTATGGTTGTGGAGGTGGGGTGGGGGACAATCATTAACTCACCAGCACCAAG
CATCACCAGCTCCCACCCGTCCCTGGTCCAAGACTTGAGTCAGCAAAATGGCGCCACAGGACACTAAAGAAGCCTTAAAACCAAGATAAT
ACGACCACCTCCACCCAATCCTGATGTTCGCAGGGCTGAAGTTAACAGAGCACAGACCACCTTTAGTTAGATGTGGCTTTCAGCCTTTTA
GGGAAAGACTCGAACAAATTTTCATCTATTCAAGAGCATGCTGTTTGCAGCACTCTTTATGGTCTCCTAGGAGCATAACTTGGAATGTAC
AGGAATATTTGTGTCCTAAAAAAATCAGCTGCCCTTCCAATATCATTTTTATAACGTTATGGTTTAATTCAAGTTATACAAAGGTGTGAC
TCAAGGATGTGCAGGTATTGACTGATGGAGGCCAACAAGGAAAATATTTTTTTTCAGTGAGCCCAGAGAAATTAGAAATCTTCACCAATG
TCAGTGACTGCATGGTTTCCAAAAATTCACATAGTATTACCTCACAGTAGGAAGGCTTCTTTCCCATTTAGGCTCAGAGAACACTTTTAC
AGAAATCAAACCTATTTACAGGGTGGCACCCCTTTTCTGTGGCATCTGATCTGTCATCTCCCAAGCTCCTGAAGTTCTTTATCCAGGTTG
TATCTTTGCTGAGCTGACAACAGATTTCTCTATGGATCAAATATTCTAATCAAGGAAAGATACGGTGAAACTTCAGTCTTCTTCTGGAGA
AATGCTGAGGCGAGATTAGTGCAGCTACATTCTGAGTTGAAGGAAATGCAGTGTTCTGAGGGCCCCTTTGTGTCCTGATGGCTGGAGGAC
GCTTCCTCCTGGTTAGATCCTCAAGCTCCTTGCCTCATTGACAAATGTCTCCTAGTCCCCTTTTTCCCTCTGACTCTGAGGAACTAAATA
GCTTGACTATCTCTAAACAGAGACTGGCCCTGCCACTGACCCTCCTGTCCCTCTCATAGCATACCCTGACAGATACTCAATAGAAAACAC
CTGCAGACCATGTGCACACTTAACTTTCCTGCCCAACCTGCCTCCCCAACGGCCCATGCTAGAATAGCTTGTGCCCAGAAAACAAACAGT
GACACTTCATCTCTTCAGCGTCAGAAAATGGGCATAGAATGTACCCATGCAATTGAATGTATCTCATTCTCCACTGGCATAGTAGATATA
AACTATTCCTTTGCCTACCTTTTACTGCCTTATCCTGGAAATATTGGGGAAAATAAGCCATATCAGTGAGATTTACCTAAAAACAAAGGA
AGGAAAGTCACTATGGAAACCAAGTAGATGCTTTTTGTAAGTTTGGTGGAGCATAACTGGCCCAGAAGTCTGGGTGCCTGAGTTCTAGTT
CGTGCTCTGTCAACTGGTAGATTTGTAATTCTAGGTCTTGGTTTTCTTACCTGGTGAATAAGTCATGATCTCTAAAACCCTTCCTGCCCT
TAATATTGTCTGAATTTCAAGGGGAAAAAAAAAATCTGGTTCCTTTAATTATTTTTTTTTAACACTTAAATTCCTAACTTTATTAGACAA
GAAGTATGGCCCACTTAACAGTTAAGGAACGTAAATTTGTTATTGGCTCGAAATAATAATTTGACACAATACTAGTCAACCATTTAGAGG
CCTTGGAAAAAGAAGAGGAACAGCACTGAAAATTCCAAGTATGATTGGAAATTATCTGGGAGCGGGGAATTAAATATTCAATGCATGAAA
GCAATTGTACTGGCTTCTGGGAAAAAGGAAACAAGAACATTGCTATGGAACTTGTTACCCAGAGAAAGGAAGTGAAAAGATTTACAATTA
TAAGCACGAAATTCATTGGCAGATTACCTGCTTTATCTACAGACAGATTGTTTTGGGGTTTGGTTTTGTCTAGGCAGCCTCTGGCCAGGC
TCCTTAATTGCTTGCTCTGCTAATATTTCAGCTTCCTCTCTTGACTCCTTGAGGAACCAACCGCTCTTTGGAAGACAAACACTTAGCCAC
CTCTGTGCTCCAGGGTAACCCTGAGAAGCTCTGCTGTCTGGGGCAAGCTTTCTTTCCAAAGGGAATGAGAGGAAGGCAAGCAGGCAGGGT
CCTGCAGCGTCAGGCCTTCTGGGGAAAGTTTCCTCATTTTGTTTGACAGGGTCCTCAGTACATCAGACACCCAGATTTGAATATAAGTTC
AGAGCCTGATCTCAAGCTAAATCAGAATGCTTTGGGGACTAACCATGATCGAGAATTGGCCAAATAGTATGGCATATAAACAGCCATCCA
GCCAGCCGCAAGTAAAGGAACGTTTGATCCTTGGCACCTTAAATGATTGATTGCCTTCAATAGGCAAACTGCTGGTCTGGAAATCTCGTT
GAAGGCTGAATACTTCATGCGGAGTAGGACAAGCCTTAGCCCACCTTCAGGTTGAAAGGAAAGGCCATAGGACTCAAAAGATAATGACTC
TGAAACTAAACTCCTTCCTTCTGAAGCTGACAGAGGTACTTAGTGCATCTCAAGACTCCATCTCATAAAACTCATTTGTGAGGGATTTGC
TCTAGATTTTTCTAAACATTTTTTCATCTATTGTCCAGACTTGCAAATCCAGTGTGGACCTGATGGAGATACCCTTCACACCTGCGCTCC
CACCCCCTCGGCAGGGAGACGTCTCAGTAGAGGAGAACACACCCATTATGCTGGGATTTGTATTTATAAATCACTTCCCTTTTAGGGATG
AGCGGTGTGGGGCGTGTGTGCGTGTGAGTGTATGCGCGTGCGTGTGTGACCCTCAAGTGTACTTTGCTCAATTTAGACGTGCAGTATTTC
CAGAAACAATGAAAAAAGTAAGATGTTTTCTTCTTTATGATTCTGCTCAAAACACCACGTGCCGCCTCAGAGCTTTTTCTAGAGCCTCGG
TCCTCAATGACGCGCTTGACCTGTTGATGCCTCAGCCCAGCGAAGCCCCTCACCTGTGCCCCGGGCGACAGCTCTTCAGTGTGCAGTGCA
GGCCTGGGGTGGACTGCCAGGCCTTCGCTCTGTGCCAGCAACGCCGTTCTTGTTGCTCCTCCATGAACAGGGGTACAAGCCCTGGCCCCT
CCTCGACACTAAGCCCCCCACAGACTCAGCCTCCAAGGAACCGCTGAGCACCCTTGAAGCATGTCATTGTCAGTGATACCTTTTTATTCT
ATGGAACTCTAACCTATTCGTGTCATATTGACCTTTTGCTGCATGAGTCATAAATTATGAAATCAGTCTTACAGTTTTTGAAATGTAGCC
AGCATTTGTAAGGCTAAACCTTTTTCATGAACTGAATTTAAGTGAATAACCAAGCCACAGTTCCTCCTCAAATGGAGAGTGATGATCGAC
ATTTGAATCTCTTTGCCCTTTCCAACGGCTATGGCATCAGGTTCTAAAATAAGCTCGTAATTTTTCCTGTTATTTTAATAATATGGAAAT
ATTAGCATAGTGTTTCTTTTGATAGTGATAGACTATAATCCATATTTAAATTTTATAGAGAAGAAATTTTATTGTACTGTGATGTAGATA
TTTATTATCCAGGTAAGGATTTGCCCGGTGTGTATTTTTTACAATTGAGACATTTTACTTTAATCTTTAAAAAAAATGCATTAAAAACAC
ACTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACCAGACTGGGGGAAAAAAGGTTTGGCCTTATCACAGAATTTTTACTGTGCTGTATA
AATGTTTGCAAATGCGAAAAGTGTGCATTTATAGTGTGTTTCCACATTAATTAATGCCGCCTTCAAGAGCAATATTGTGCAGGTAAAACG
CTGTTTGTGGCTTTCTGTTGCACAGTTAAAGCTGACCCACCCTATGCACAAGACAATCAAATATAAATCTGTCCTCCTCAGGATGCAGAT
AATACTCATGTAAATTATGGAGCACAATGTAAGACAAAAGGAGACACTTTACATATGTATTGTTGATACAGAAATTATCAGGGCATGAAT
GAGCTGATGTGACATTATGCCACTTCTTTCTTTTGGTTCTCCCTTATTAACTTGGCATTTTTAATTTGACCATAGAGCCAAATTAGTTCT
CCATGCTTTCTTCGTAGAAAATCCTTTTTTTTCCCATAATGTTTTCATGCCCTGAGAATCAGAAAAATACTACAGAATAGAAAAAGATTT
ACAGTCATTGGAAGATTTGTGTTTTGCAAACAGTGTTAAGTGATATTGCTAGATGGTGATATTTTTTTCAGCCTAAAACTCTGTTGAAAT
CTGTGATCAAAATGTTTTAAACTATCCAAAAAAAATTTGTATATTTGGGAAAAATGGATTTTTACATAGCTTTTGTATGCAGATATAAAA
CTGTAATTATGAATATAGTGGGCGTAGATAAACTCATAAGCTTAAATTCTAAAAAAGAAAAAGCTTATAACAGATATATTTTCCTGTCTC
TTTCTTTAAATATTATTATTTTCTACATAGGCAAAGAGTTGCCTGCTCTTCTCACTTCAGCTGCTGCCAAAAGACGGAACCACGGATGTA
AGGACATTTATTTCATAAATAAACATCTACTAGAATAAGCAAATTTACTTGAGAAGAAACTATGGAGGGAGAGAAGAAACTAAGTAAAAT
GCTGATGGGGGGTTACCTCTTTGGAAGGGGCCACAAAGATGAAGGGAGGAGAGAGGTGAAGTTTTGCAGCTCAAGGACAACATTCATCTT
CTCATCTCAAATTATTCAGGAATATTACTAATGGAATTATGTTAACATCAGCTGCCAACATATATCTCAATCTCTGTTGCCCTGAACACA
TGTTAATTGAGATTCTTTCTATGACAAGTAACAAAAAGCTAACTCAAACTGGCTTAAGCAGAAAGCTAATTATTGACTTTAATATCTGGG
ATCTAGGGTATTGCATACCAAAGCTTCAGGCATGGCTGGATCTGGGTGCACTTACTCAGTATTCTCAGGAAGCTCCTTTTTTTGTCATTC
ATGTAGACTTAACATTCACATGGCCTTTCACCTTACGGTGGCCTCCAATAGCTCCAGGATGAGCTTTACAGCTCCAAATATAGTGAAAGG
AGAATTTCTTTTCTCCAACAATTCTAATGAAAATTCTGGCCTAATTCTCACTGGCCCAAGTTCAGTCATGTGCCCATTCCTGAGCCAATC
ACTGTGGTGAGGAAAACAGATGCATAACCAACCTTATCCTCAGGAATCCTGGAACTGGGTGAGGGGAAAGAGGGACAGTCAGCTTCATCT
AAACTATGGACTGAGAGTTGAGGCAAGATGATTCCTGAAAGAAAATTCTAAGTCTTGCTGCTATAAGTGGAAGAGAATGGTGGGCAAGCA
AAAGCAACCAGTGCCCACACCAAAGGTAAATCTAAAACAACATCCCATTTCAGTACAGCAAGCGGTTCTCCTTCACACAGAGGAAGCTCA
TCTCCAAGTTTTTATTTGGCCAGGACATGAACCAAATAAACACCTTCC

>2753_2753_3_AFTPH-THRB_AFTPH_chr2_64812679_ENST00000487769_THRB_chr3_24193981_ENST00000396671_length(amino acids)=288AA_BP=
MATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGK
VDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAI
FDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK
VECPTELFPPLFLEVFED

--------------------------------------------------------------
>2753_2753_4_AFTPH-THRB_AFTPH_chr2_64812679_ENST00000487769_THRB_chr3_24193981_ENST00000416420_length(transcript)=2560nt_BP=781nt
TTTCCACATTTTAGTGAACCAGGTGATGACTTTGGAGAATTTGGGGATATAAATGCTGTTTCTTGCCAAGAGGAGACAATATTAACAAAG
TCAGACCTAAAACAGACTTCTGATAATTTATCAGAAGAATGTCAATTGGCAAGAAAATCTAGTGGAACAGGCACTGAACCTGTTGCAAAA
CTTAAAAATGGGCAAGAAGGTGAGATTGGACATTTTGATTCTGTGCCAAATATTCAGGATGACTGCAATGGTTTTCAAGACTCTGATGAT
TTTGCAGACTTCAGTTCAGCTGGTCCTAGCCAAGTTGTAGATTGGAATGCTTTTGAGGATGAACAAAAAGATAGTTGTTCTTGGGCTGCT
TTTGGAGACCAGCAGGCTACTGAATCTCATCATCGAAAGGAAGCCTGGCAGTCACATAGGACAGATGAAAATATTGATACTCCAGGAACC
CCCAAAACGCACAGTGTACCTTCAGCAACTTCCAAAGGAGCAGTTGCTAGTGGCCATTTACAGGAATCAGCCACTTCAGTTCAGGGTATG
TTAGAGCCCACCAAGGAACCACTGAAACCACTTTCTGCTGCAGAAAAAATAGCTTCCATCGGTCAGACAGCCACCATGTCACCAGATATG
AACACATGTACATCTGATCAGTTCCAGGTGTGGATCCGGAGTTGTATGAGTTAACAACTTCTAAGCTGGAAATCTCCACCTCAAGCCTCA
AAGTGACTGATGCATTTGCAAGACTCATGTCTACAGTAGAGAAGACAAGCACATCTACCAGGGTACATCCCCAGTTACTTAGACAAGGAC
GAGCTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACC
ATTCAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGT
CGCTTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAG
AACCGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACT
GTCACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAGCAAAAACGGAAATTCCTGCCAGAAGACATTGGACAAGCACCA
ATAGTCAATGCCCCAGAAGGTGGAAAGGTTGACTTGGAAGCCTTCAGCCATTTTACAAAAATCATCACACCAGCAATTACCAGAGTGGTG
GATTTTGCCAAAAAGTTGCCTATGTTTTGTGAGCTGCCATGTGAAGACCAGATCATCCTCCTCAAAGGCTGCTGCATGGAGATCATGTCC
CTTCGCGCTGCTGTGCGCTATGACCCAGAAAGTGAGACTTTAACCTTGAATGGGGAAATGGCAGTGACACGGGGCCAGCTGAAAAATGGG
GGTCTTGGGGTGGTGTCAGACGCCATCTTTGACCTGGGCATGTCTCTGTCTTCTTTCAACCTGGATGACACTGAAGTAGCCCTCCTTCAG
GCCGTCCTGCTGATGTCTTCAGATCGCCCGGGGCTTGCCTGTGTTGAGAGAATAGAAAAGTACCAAGATAGTTTCCTGCTGGCCTTTGAA
CACTATATCAATTACCGAAAACACCACGTGACACACTTTTGGCCAAAACTCCTGATGAAGGTGACAGATCTGCGGATGATAGGAGCCTGC
CATGCCAGCCGCTTCCTGCACATGAAGGTGGAATGCCCCACAGAACTCTTCCCCCCTTTGTTCTTGGAAGTGTTCGAGGATTAGACTGAC
TGGATTCATTCTCATAATTCCTACAGCACTACTGGGTGTCATTTCATTCCATTGCCTAGCTCTTTTTTGTTTGTTTCTTTGTGTTGGGAG
GGATTATTTGGGAGGGAAAAGGGAAGTAGTCCTTGGCATAGACATGGATGAAATTGCCCCTTGAATGCGGGTACTTGAAACTATTGCATT
TCGTTCTCCGGTCCTGTGATGTGAATGCTCTGAAGGTTTTATGGTTGTGGAGGTGGGGTGGGGGACAATCATTAACTCACCAGCACCAAG
CATCACCAGCTCCCACCCGTCCCTGGTCCAAGACTTGAGTCAGCAAAATGGCGCCACAGGACACTAAAGAAGCCTTAAAACCAAGATAAT
ACGACCACCTCCACCCAATCCTGATGTTCGCAGGGCTGAAGTTAACAGAGCACAGACCACCTTTAGTTAGATGTGGCTTTCAGCCTTTTA
GGGAAAGACTCGAACAAATTTTCATCTATTCAAGAGCATGCTGTTTGCAGCACTCTTTATGGTCTCCTAGGAGCATAACTTGGAATGTAC
AGGAATATTTGTGTCCTAAAAAAATCAGCTGCCCTTCCAATATCATTTTTATAACGTTATGGTTTAATTCAAGTTATACAAAGGTGTGAC
TCAAGGATGTGCAGGTATTGACTGATGGAGGCCAACAAGG

>2753_2753_4_AFTPH-THRB_AFTPH_chr2_64812679_ENST00000487769_THRB_chr3_24193981_ENST00000416420_length(amino acids)=288AA_BP=
MATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGK
VDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAI
FDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK
VECPTELFPPLFLEVFED

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AFTPH-THRB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneAFTPHchr2:64812679chr3:24193981ENST00000238855+9101_523887.6666666666666937.0AP1G1%2C AP1G2%2C GGA1 and GGA3
HgeneAFTPHchr2:64812679chr3:24193981ENST00000238856+891_523859.6666666666666910.0AP1G1%2C AP1G2%2C GGA1 and GGA3
HgeneAFTPHchr2:64812679chr3:24193981ENST00000409933+891_523887.6666666666666937.0AP1G1%2C AP1G2%2C GGA1 and GGA3
HgeneAFTPHchr2:64812679chr3:24193981ENST00000422803+9101_523887.6666666666666938.0AP1G1%2C AP1G2%2C GGA1 and GGA3
HgeneAFTPHchr2:64812679chr3:24193981ENST00000238855+910386_610887.6666666666666937.0AP1G1
HgeneAFTPHchr2:64812679chr3:24193981ENST00000238856+89386_610859.6666666666666910.0AP1G1
HgeneAFTPHchr2:64812679chr3:24193981ENST00000409933+89386_610887.6666666666666937.0AP1G1
HgeneAFTPHchr2:64812679chr3:24193981ENST00000422803+910386_610887.6666666666666938.0AP1G1
TgeneTHRBchr2:64812679chr3:24193981ENST0000028069607244_461109.33333333333333477.0NR2F6
TgeneTHRBchr2:64812679chr3:24193981ENST00000356447310244_46194.33333333333333462.0NR2F6
TgeneTHRBchr2:64812679chr3:24193981ENST00000396671411244_46194.33333333333333462.0NR2F6
TgeneTHRBchr2:64812679chr3:24193981ENST00000416420512244_46194.33333333333333462.0NR2F6


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AFTPH-THRB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AFTPH-THRB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC2937288THYROID HORMONE RESISTANCE, GENERALIZED, AUTOSOMAL DOMINANT20CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC1840364THYROID HORMONE RESISTANCE, SELECTIVE PITUITARY3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC2940786Thyroid Hormone Resistance Syndrome3CTD_human;GENOMICS_ENGLAND
TgeneC4722330Generalized Thyroid Hormone Resistance3CTD_human;GENOMICS_ENGLAND
TgeneC0004238Atrial Fibrillation2CTD_human
TgeneC0235480Paroxysmal atrial fibrillation2CTD_human
TgeneC2585653Persistent atrial fibrillation2CTD_human
TgeneC3468561familial atrial fibrillation2CTD_human
TgeneC0019284Diaphragmatic Hernia1CTD_human
TgeneC0206682Follicular thyroid carcinoma1CTD_human
TgeneC0376634Craniofacial Abnormalities1CTD_human
TgeneC3489796Thyroid Hormone Resistance, Generalized, Autosomal Recessive1CTD_human;GENOMICS_ENGLAND
TgeneC4273673Peripheral resistance to thyroid hormone1GENOMICS_ENGLAND