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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:APTX-ARL5B (FusionGDB2 ID:HG54840TG221079) |
Fusion Gene Summary for APTX-ARL5B |
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Fusion gene information | Fusion gene name: APTX-ARL5B | Fusion gene ID: hg54840tg221079 | Hgene | Tgene | Gene symbol | APTX | ARL5B | Gene ID | 54840 | 221079 |
Gene name | aprataxin | ADP ribosylation factor like GTPase 5B | |
Synonyms | AOA|AOA1|AXA1|EAOH|EOAHA|FHA-HIT | ARL8 | |
Cytomap | ('APTX')('ARL5B') 9p21.1 | 10p12.31 | |
Type of gene | protein-coding | protein-coding | |
Description | aprataxinforkhead-associated domain histidine triad-like protein | ADP-ribosylation factor-like protein 5BADP-ribosylation factor-like 5BADP-ribosylation factor-like 8ADP-ribosylation factor-like protein 8ADP-ribosylation-like factor 8 | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000397172, ENST00000309615, ENST00000379813, ENST00000379817, ENST00000379819, ENST00000379825, ENST00000436040, ENST00000463596, ENST00000468275, ENST00000473270, ENST00000476858, | ||
Fusion gene scores | * DoF score | 10 X 9 X 6=540 | 5 X 5 X 3=75 |
# samples | 12 | 6 | |
** MAII score | log2(12/540*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: APTX [Title/Abstract] AND ARL5B [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | APTX(32987758)-ARL5B(18961551), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | APTX-ARL5B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. APTX-ARL5B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. APTX-ARL5B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. APTX-ARL5B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | APTX | GO:0000012 | single strand break repair | 17519253 |
Hgene | APTX | GO:0042542 | response to hydrogen peroxide | 15044383 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUSC | TCGA-39-5037-01A | APTX | chr9 | 32987758 | - | ARL5B | chr10 | 18961551 | + |
ChimerDB4 | LUSC | TCGA-39-5037 | APTX | chr9 | 32987758 | - | ARL5B | chr10 | 18961551 | + |
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Fusion Gene ORF analysis for APTX-ARL5B |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000397172 | ENST00000377275 | APTX | chr9 | 32987758 | - | ARL5B | chr10 | 18961551 | + |
intron-3CDS | ENST00000309615 | ENST00000377275 | APTX | chr9 | 32987758 | - | ARL5B | chr10 | 18961551 | + |
intron-3CDS | ENST00000379813 | ENST00000377275 | APTX | chr9 | 32987758 | - | ARL5B | chr10 | 18961551 | + |
intron-3CDS | ENST00000379817 | ENST00000377275 | APTX | chr9 | 32987758 | - | ARL5B | chr10 | 18961551 | + |
intron-3CDS | ENST00000379819 | ENST00000377275 | APTX | chr9 | 32987758 | - | ARL5B | chr10 | 18961551 | + |
intron-3CDS | ENST00000379825 | ENST00000377275 | APTX | chr9 | 32987758 | - | ARL5B | chr10 | 18961551 | + |
intron-3CDS | ENST00000436040 | ENST00000377275 | APTX | chr9 | 32987758 | - | ARL5B | chr10 | 18961551 | + |
intron-3CDS | ENST00000463596 | ENST00000377275 | APTX | chr9 | 32987758 | - | ARL5B | chr10 | 18961551 | + |
intron-3CDS | ENST00000468275 | ENST00000377275 | APTX | chr9 | 32987758 | - | ARL5B | chr10 | 18961551 | + |
intron-3CDS | ENST00000473270 | ENST00000377275 | APTX | chr9 | 32987758 | - | ARL5B | chr10 | 18961551 | + |
intron-3CDS | ENST00000476858 | ENST00000377275 | APTX | chr9 | 32987758 | - | ARL5B | chr10 | 18961551 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000397172 | APTX | chr9 | 32987758 | - | ENST00000377275 | ARL5B | chr10 | 18961551 | + | 7020 | 312 | 3 | 596 | 197 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000397172 | ENST00000377275 | APTX | chr9 | 32987758 | - | ARL5B | chr10 | 18961551 | + | 0.00160633 | 0.9983936 |
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Fusion Genomic Features for APTX-ARL5B |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
APTX | chr9 | 32987757 | - | ARL5B | chr10 | 18961550 | + | 1.82E-06 | 0.9999982 |
APTX | chr9 | 32987757 | - | ARL5B | chr10 | 18961550 | + | 1.82E-06 | 0.9999982 |
APTX | chr9 | 32987757 | - | ARL5B | chr10 | 18961550 | + | 1.82E-06 | 0.9999982 |
APTX | chr9 | 32987757 | - | ARL5B | chr10 | 18961550 | + | 1.82E-06 | 0.9999982 |
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Fusion Protein Features for APTX-ARL5B |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:32987758/chr10:18961551) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000397172 | - | 4 | 8 | 38_87 | 103 | 285.0 | Domain | Note=FHA-like |
Tgene | ARL5B | chr9:32987758 | chr10:18961551 | ENST00000377275 | 2 | 6 | 125_128 | 85 | 180.0 | Nucleotide binding | Note=GTP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000309615 | - | 1 | 8 | 182_287 | 0 | 307.0 | Domain | HIT |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000309615 | - | 1 | 8 | 38_87 | 0 | 307.0 | Domain | Note=FHA-like |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379813 | - | 1 | 8 | 182_287 | 0 | 343.0 | Domain | HIT |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379813 | - | 1 | 8 | 38_87 | 0 | 343.0 | Domain | Note=FHA-like |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379817 | - | 1 | 7 | 182_287 | 0 | 343.0 | Domain | HIT |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379817 | - | 1 | 7 | 38_87 | 0 | 343.0 | Domain | Note=FHA-like |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379819 | - | 1 | 8 | 182_287 | 0 | 357.0 | Domain | HIT |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379819 | - | 1 | 8 | 38_87 | 0 | 357.0 | Domain | Note=FHA-like |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379825 | - | 1 | 8 | 182_287 | 0 | 307.0 | Domain | HIT |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379825 | - | 1 | 8 | 38_87 | 0 | 307.0 | Domain | Note=FHA-like |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000397172 | - | 4 | 8 | 182_287 | 103 | 285.0 | Domain | HIT |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000436040 | - | 1 | 6 | 182_287 | 0 | 445.0 | Domain | HIT |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000436040 | - | 1 | 6 | 38_87 | 0 | 445.0 | Domain | Note=FHA-like |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000463596 | - | 1 | 8 | 182_287 | 0 | 343.0 | Domain | HIT |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000463596 | - | 1 | 8 | 38_87 | 0 | 343.0 | Domain | Note=FHA-like |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000468275 | - | 1 | 8 | 182_287 | 0 | 343.0 | Domain | HIT |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000468275 | - | 1 | 8 | 38_87 | 0 | 343.0 | Domain | Note=FHA-like |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000476858 | - | 1 | 7 | 182_287 | 0 | 303.0 | Domain | HIT |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000476858 | - | 1 | 7 | 38_87 | 0 | 303.0 | Domain | Note=FHA-like |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000309615 | - | 1 | 8 | 126_131 | 0 | 307.0 | Motif | Nuclear localization signal |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000309615 | - | 1 | 8 | 272_276 | 0 | 307.0 | Motif | Histidine triad motif |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379813 | - | 1 | 8 | 126_131 | 0 | 343.0 | Motif | Nuclear localization signal |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379813 | - | 1 | 8 | 272_276 | 0 | 343.0 | Motif | Histidine triad motif |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379817 | - | 1 | 7 | 126_131 | 0 | 343.0 | Motif | Nuclear localization signal |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379817 | - | 1 | 7 | 272_276 | 0 | 343.0 | Motif | Histidine triad motif |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379819 | - | 1 | 8 | 126_131 | 0 | 357.0 | Motif | Nuclear localization signal |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379819 | - | 1 | 8 | 272_276 | 0 | 357.0 | Motif | Histidine triad motif |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379825 | - | 1 | 8 | 126_131 | 0 | 307.0 | Motif | Nuclear localization signal |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379825 | - | 1 | 8 | 272_276 | 0 | 307.0 | Motif | Histidine triad motif |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000397172 | - | 4 | 8 | 126_131 | 103 | 285.0 | Motif | Nuclear localization signal |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000397172 | - | 4 | 8 | 272_276 | 103 | 285.0 | Motif | Histidine triad motif |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000436040 | - | 1 | 6 | 126_131 | 0 | 445.0 | Motif | Nuclear localization signal |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000436040 | - | 1 | 6 | 272_276 | 0 | 445.0 | Motif | Histidine triad motif |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000463596 | - | 1 | 8 | 126_131 | 0 | 343.0 | Motif | Nuclear localization signal |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000463596 | - | 1 | 8 | 272_276 | 0 | 343.0 | Motif | Histidine triad motif |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000468275 | - | 1 | 8 | 126_131 | 0 | 343.0 | Motif | Nuclear localization signal |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000468275 | - | 1 | 8 | 272_276 | 0 | 343.0 | Motif | Histidine triad motif |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000476858 | - | 1 | 7 | 126_131 | 0 | 303.0 | Motif | Nuclear localization signal |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000476858 | - | 1 | 7 | 272_276 | 0 | 303.0 | Motif | Histidine triad motif |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000309615 | - | 1 | 8 | 331_353 | 0 | 307.0 | Zinc finger | C2H2-type |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379813 | - | 1 | 8 | 331_353 | 0 | 343.0 | Zinc finger | C2H2-type |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379817 | - | 1 | 7 | 331_353 | 0 | 343.0 | Zinc finger | C2H2-type |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379819 | - | 1 | 8 | 331_353 | 0 | 357.0 | Zinc finger | C2H2-type |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379825 | - | 1 | 8 | 331_353 | 0 | 307.0 | Zinc finger | C2H2-type |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000397172 | - | 4 | 8 | 331_353 | 103 | 285.0 | Zinc finger | C2H2-type |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000436040 | - | 1 | 6 | 331_353 | 0 | 445.0 | Zinc finger | C2H2-type |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000463596 | - | 1 | 8 | 331_353 | 0 | 343.0 | Zinc finger | C2H2-type |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000468275 | - | 1 | 8 | 331_353 | 0 | 343.0 | Zinc finger | C2H2-type |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000476858 | - | 1 | 7 | 331_353 | 0 | 303.0 | Zinc finger | C2H2-type |
Tgene | ARL5B | chr9:32987758 | chr10:18961551 | ENST00000377275 | 2 | 6 | 23_30 | 85 | 180.0 | Nucleotide binding | Note=GTP | |
Tgene | ARL5B | chr9:32987758 | chr10:18961551 | ENST00000377275 | 2 | 6 | 66_70 | 85 | 180.0 | Nucleotide binding | GTP |
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Fusion Gene Sequence for APTX-ARL5B |
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>5719_5719_1_APTX-ARL5B_APTX_chr9_32987758_ENST00000397172_ARL5B_chr10_18961551_ENST00000377275_length(transcript)=7020nt_BP=312nt CAGATGAGTAACGTGAATTTGTCCGTCTCCGACTTCTGGAGAGTGATGATGCGGGTGTGCTGGTTGGTGAGACAGGACAGCCGGCACCAG CGAATCAGACTTCCACATTTGGAAGCAGTTGTGATTGGGCGTGGCCCAGAGACCAAGATCACTGATAAGAAATGTTCTCGACAGCAAGTA CAGTTGAAAGCAGAGTGTAACAAGGGATATGTCAAGGTAAAGCAGGTAGGAGTCAATCCCACCAGCATTGACTCAGTCGTAATTGGGAAG GACCAAGAGGTGAAGCTGCAGCCTGGCCAGGTTCTCCACATGTTCATCATTCTTGTTGTTGATAGCATTGACAGGGAACGACTAGCTATT ACAAAAGAAGAATTATACAGAATGTTGGCTCATGAGGATTTACGGAAGGCTGCAGTCCTTATCTTTGCAAATAAACAGGATATGAAAGGG TGTATGACAGCAGCTGAAATCTCGAAATACCTCACCCTTAGTTCAATTAAGGATCATCCATGGCACATTCAATCCTGCTGTGCTCTCACA GGAGAAGGGTTATGCCAAGGTCTAGAGTGGATGACCTCCCGGATTGGTGTGAGATAACTTTTTTGCTTGAAAGAGACTGCTCTATTTATT CTGTGACATGAACATTTTTTCCTAGTACCTTTGGCTGCTAAGGCAGCAGCATGTTTAATTTATAACAACACAAACCTCTGAGAGCAACAC TTGAATCAAGTGCAGCTGAACTGGAACATAAAAGATTTTTTCTTAACTTTTTTTTTTTAACACACTAATCTTCAGTTGGATGAATGTAAT GTATAACTATGTTTTCAGCAACAATTCTTCTGTTTATTCTAATTAATCAGTGACTGCCTTGTAAGAAATGTTTGTCATATGCGTGATGTC TTCTGAAATATTCTTATAACCTTAATGACCAATTGCTTTCAATTCTTGACCAGCACTCCCTCCCAACCAGAGAATTACTGGTTTGATAGA GTAGTCTTGGAAACCATCAGGTACTGCCTGCAGACTTCTCCAGCACTAAATATATTTGTTCCCTCTATAAACCATTCATCTTTCGGACAG AACTTACTGTAAAGAAAGAAATCTGCCTAGAGGATATATGTAAGGAAGATTCCACATCATGAGTACTTGCCTTTTAACTTTCCCCCACAT TACTGTTGAGTCATGGAATAATGTTTAAGTTGTTATTTGCATGGAAATTAAGTAGGCTGTTTATTTATCTAAAGGAATCAAGTCCACTCT TCTGCCTGCAACATTTGTTCAAAAACTAACCAAGGTAAAATATTTATTTGAAAGCCCAACTTTGATGTTAAATATTCTTGAATAAATCTG TTATTTTAAGAATATCACATTATTCAATGCATATAAAACTATCAGAAGTTAGTAAATCATACCAGCACTAAAAATAAGACAATTGGAATA TATTTTAGCATCAGTTTACAAACAACTTTATTATCAACAGAAATTTTAGCTCTTTTCTTTGCAAGATATATCACAGCTGCTTTGGGCAGT AGCTGAAGCCGAAGTATGAACAGTCCATTTTGTTTCTTAAAATTTGAAGTCGTGTCTGTCATAGCATTTTTACTACCAGCAGTATGTTAC TTAAAAAACTACATGGCTTTCCTTGAATTTATTTGACGGTATTATGTAATAGACTTGAAACAATTGCCATCTTTGTAGTTATGCCTTGGG TTCTAAAATGTTATAGGAAACTGCTGAATTGAATCCTAGCTTTTAGAATATTAATAGGAGACTCAAAGTTAATATTCTTAACAACTTAAA ATTAAAAAAAGTCATAATCTATCAAAAGTTTATTTATTGGATGGCATTAAAACATTTTTGAGGCAGTTGTCTAATATGAACAATAATCTA AACAATATATTCCTTAAATTAAGAGGAAAGACAAGTGTCGTATTTCGATCCTGTTTATTCAAATGTGTGATTTTGCTGAAATGAAAGGGA TAAAATGAATACTTAGAGAATAATACTTCATTTTTGCAGTACTTTTTAATTTTGATAAAAAAGATACAAAGTTCATAATATCAAAATATG TGTTCAAAATTGGTATTTTAATTTTAATATTTTTGTAAGTTGATTTAAATTTTGCTCTTTTTTCAGGTGTGCTTGGTTTATTATATTTAG TCAAGTTAATTTAGTCGAATGTGGTAACATTTTTCTGATTTATCTTTAGTTGGAGCACACCCTTGAACTGAACAGTGGCCAAAGGAAAGC TTTCTGGGCTTTGGAAAGTAGTTGTTTAACTTTGTTTTAAGCCGTTTTCTTAGTGATTCTGTATCAAGTAGAGGATAAGTGTAGTTTAAC TTAGTTTTTAATATAACCCATAATCAAGAACATGAGCGAAAAGCAGACATAAATCGATATGGATGGTTTGTGGTGTGTGTGGGATGTGGG GGAATTAAGAAAATGCCATTTACCTAAGCACAGTTTGCCTGAATTTCTGCTTGGTTGTGTTGTTTACCGTAAGTACTGAGGGTAGTTTCC CTAAGTCTGTCCTGAGAAAAAGCATACTTAGTACTCCTGTATTTGTTCTTATGAAATGACTATCTGCCTTCTTGTATCTAGTAAGATTGG CTGGCTCAATTTTCTTCTGTCAAATTATATGGTTATTTTTTATATTACCACATCAGCATTATATTAAAAGTGTTTTTAATAGTTGATTGT ATTTTGCCAACTACTAGTATAGACTCAAATTTGCTATTTAATTTTTAAAATACAATTTATTTTGTAAATCCTTTAAAAAATATTTGGTTA GTTTTGGATTAGAAATGATTTATGTTAGCCATGTGTTGAAGATGAAATTGGCATCAGTGTAGACGGTGCTGATTGGGAAAAGTTCATGAT TAGGAAATTCATGTAAGACTTTTTAAGAGTATTTTTTAGGTTTTCACTCAATCTTTCCTGTCACAGTAACGTGAAAACTGATTATTCTTT ACTCCAAGAGAATGTTTTAACCCAAGCAAGTATCTAATACTAGAGCATTGGTTCTGACATTCATTGTAAATCAGTGAACTGTAAGATACT GTCTAAAAAATGTACATTTGTAATTAGTGCCTTTATTCATATTTTGAAATAAGTTCTTAGTTTTATATTATACCTGTTCTTTAGAAGTCA TGTTAGCAGCTAATTATTTCAGTGATGAAATAATTTGTGTTTTATATCCCCCTTCACCTCCATGTATTGGTTAGCACAGTTTATAGTAAG TGAAAAGCAAGGGACCCACCTACATTACCTTCAGGAGACTGTTCTACCTTTTAATTTGAAAACAAGGAAATTAAATTTTAACAGAAATCT TTTAAGTATGTTATAACCAAAGTGTTCAATTATCCTTGCAAGTTCAAATACAGCATTTTTCTTAATTTTGAGCGTGTCATGTCCTTCATC TTTAAACCCATCATTCTTATTGAAGCCCATTTGAGAACTCTTAGAATTAATAGAACCTTTTATAAGGGAATATATGGAATATTTTTTATT GTTAATGTAACTTAATTCCTTAAAACCTGGAATATTAATATATATAATCTATTAAAAGCTGAAGATTAAATATGTAATTTTTGCTTTTAG TTTCTTGTGTTAGTATGCTTAAAGGTATCAATACTTTTATTCTATATTCATTAGAAGAAAGGTAATAAATTTAAGTTTCATTGCTGAAAA ATTTTAAATGAGTGCCACCCCATAGCCATAGTCATTTTGATTAAGCATAATTTAACTTTCATTATAGCATAAAGAGAAAATAATTATTTT AGTATGGAAACAGTGATAGGCAGTGCTGTAAACAATATTCTCTGAAAAGTTGTGGGGGTCACAAAGAAAATTTTAAAGAATATAGAAGCT TTTTTAAAAAATCTTTTTAGTGTAGTTTCTTAGAACAAATTATAAACATAATCATTCTGAATAATCAATTTTTATTTAGTCCTTAACTAT GTAAAACCGTATCAGTAGAAAAATGTGCTGGTGTCGTGTCTAAAGATGGATAAATTTCTTTGGAATTTATCTTTGGAGACCAACTTTATG AGGCAGACTTTTTGTCTACAGCTTTGGAACCAAAAAAACTTCACTCTAATTCAGTCCTAAAGGCTATTTTACATTTTGCCGGGGTAAAGT GACTTCAAGATACAGCATGGTGTCTTGTATCTAGTAGAATATTGTGCTAGCCATCTAAAAAAGTGGATTTGAGCCTTAATTTGGCCGTTT CTCAATTGTCTAGTTGACCTTAGACAATTAGTGTCCATGGCTTTCCTTTTGTTTTTCCCATACTGAGGAACTTAAACTACAGCTCTAAAA TGTCTTTTGGTTTTAAAATTCTGAATGCTTATATACTACTATTAAAAATTAAAAATCCCTCAAATAGTAGGGCAATACAGGTAATATGAA ATTAAATGTATTTTTATCCATTATTTGATTCCCACCTGTTATTTTATTTAGAATACGAATACAACCAAGTAGGGAAAAACGTATCAGTAA CTGCTATTCAACTTAAATTCAGCGAATTAATAGCTGAATAGAAATAGCTAATGACAATGCAAAAGAGAAAACAAGCCATATTGCTAAGAA AAGGATAGTAAGCTGCTTAGAAAGAACCAGCCTGTGTTGGAAATAATTCTCTTCTAGATAATTTACCTTATTTTCTTGGCTTGTACTAAT TGAATGGAAGTGGTTAATTTGTTCAGAGTTTATTGCCGTTTGATGCCACCCCAGTCTATAGTTCTGTGTGACTTTCCATATTGAAAGAGT AGGGTTAGTAGCCAGGTTGTCAGTCTTTTACAAATGTCTACATAAATGTCTACATAAATCTGAAAGTGGTTTATATTCAAGGTTAGTTTT TCAGTAGCGTCTCCTCCTTATTCATTCACTTTTACTGTGAAGACTGAAATCCAAAAGCCAGGTTCCCCAAAAAAGTATTTTTAAAAAATT TTAGGGGACCAAAATAAATAGAGGAAGACCAATATAAAAAAATATGTTCAACTATTCCATTTTAAATTTAAAGCAGAAAAAAAAATTGTG CCCCTCAGACCTAAAGGCAGCTTTAAATGTATATAGTTTGGTGAAACATTTGGGAAATATTAATTTGGAGGTTTAGAAGCATACGAAAAA CAAATTCAAAGCACTTGAAAGTAAAGACAATATCATGAGGTCGAAAAAACTTCAAAAGGATATTAGGTAAGAGAAAATGTGAATGAAAGC AGTGAATTTCTGCCTCTCCTCGTATTTAGGGTACTTAAAATTACTAAAAAATACTGTCTTTTTACCATACAGCTAGATGGCCTGTATTAT TCTTAATGTGGCCAAAGGAGTGAAGACTGATTAGGGTTTTAGAATTTGGAACTGTAGTCACATAAAGGCATCTTTTGCATTTCTTAAACC AGTAATCTACATTTTCTCCTGGAAATGGAGAAATATGAAATGTGCTGTGCATAGCTTTTGGAATAGAAAACAAAGTTTTAAAAGAATGGA TATGTTTTCTTGCACAACTTGTAAAATTTTAATTAAAAAATTACCTCATTTTTCAATCCATAAGGTGCTTTGCTCAAGTTTGTGGGATGT TTGTACCATCCCATAAAAACCCCCTTCACCCAAACTGTATTTGAAATATGCAAAATTCATAACTAAGGGATAGCATTCCTTGGAGACTTT GTTTTGTTTTACTCTTGTTTACCAGCTGGGCCAACATGGTAGATATATGAGATTCACATATGGTTTCATTAAAGCACATAGGAAAGTGCT CAGTCAATATTTAATTAGTTTAATTAGATAAGGGAAAGGAGAAATCCTAAATTTGATGGATTCTTTTATACTGTGAATATATTTCCATCA GTGTTGGTAAGATATCAAATGACTATCAGTTGATCCCAGTCATCAGTGACTTATTTGCATATTTAAGCCCTATTCACAAGAGACCATAAT CATTTTAATCTTATATTTTCCCTCAGGAAATTTAGGGACTCTGAAGCCCCTATTTTATTCTCTTGGAGTAAACTGTTGAGTGTAGTTACA AAAACTTTTATTTATGACTTAAAAAAAGTTTAGCTGCTATTTCAGTGAAAGTGTAAAATAAAACGGTCATGATTTTTTTCAATTACAGAA TAGTTACAAATTTTACCATGTTCATCTATTCCACAGAGCATGTTAAAAACAACAACAACAAAAACCTAACAGCAATTACAACCTTGGTGT TGCGTTTATTCTAATCAGAGTGAATGATTATAATCACACTTTGCTATTTTAACATAAATTGGTGCTTTAGAGCATTAAAGAGGAAGCAGC AGGCCCTGTACTCAGTATTTATTATTTCTTGCCTCAGAATGCAAAACAACTTTAAAGTGTCTATATTCATATATATGTGCATTTCTTAAG ATTTAAATACAAACTGTTGTTACTCCTTAAGCTTCAGGCTTTCTGCGAAAGCTCTAAGAATATCTTCATTACTATGCTTGGTCAACTGGA AGATGGTATTAATAAGGTCAGAATTAGGAATTGGATTGCTCTGTGGGTCCTCCGGTATTGTGCAGAGGAAAGAAAAATGTCTTTCACACC ACAAACTGTGTGTCTGAACCCCAGCCAAACAAATGTGTTCCATTGGTCCAATATATAAGCATTAACAACAACAACAAAAAATTTAAAACA AGTAAATTAATGCATTCACATGATCACTTCTTGAAAATGGTTCAAAGCATGTTTTCCTGATGGTGGGATTGTTTAAATGACATGTTTTAA AGTTTTTAATACTTTATTAGTTATGAAGTGCTTCTTTTATATGTTAAGTTTAGGTTGCCAGTACTCATAATTTTTATTTCTGCAATTATG TTATAATGAGTTGTTTGCATGCCTACTTAACCCAAGTAAAACGATGCTGTTTGCTCTGGAATGTTCATCTTTTAGACAGGTTTTGGCTCA TTTCCAATCATGGTGCAATATAGTGTAACATTCATTTGTTTTCATTCAACAGTTTTATTTTTGTCATAATAAATAATTACTTTTCCAATA >5719_5719_1_APTX-ARL5B_APTX_chr9_32987758_ENST00000397172_ARL5B_chr10_18961551_ENST00000377275_length(amino acids)=197AA_BP=103 MSNVNLSVSDFWRVMMRVCWLVRQDSRHQRIRLPHLEAVVIGRGPETKITDKKCSRQQVQLKAECNKGYVKVKQVGVNPTSIDSVVIGKD QEVKLQPGQVLHMFIILVVDSIDRERLAITKEELYRMLAHEDLRKAAVLIFANKQDMKGCMTAAEISKYLTLSSIKDHPWHIQSCCALTG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for APTX-ARL5B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000309615 | - | 1 | 8 | 207_211 | 0 | 307.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000309615 | - | 1 | 8 | 269_270 | 0 | 307.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379813 | - | 1 | 8 | 207_211 | 0 | 343.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379813 | - | 1 | 8 | 269_270 | 0 | 343.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379817 | - | 1 | 7 | 207_211 | 0 | 343.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379817 | - | 1 | 7 | 269_270 | 0 | 343.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379819 | - | 1 | 8 | 207_211 | 0.0 | 357.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379819 | - | 1 | 8 | 269_270 | 0.0 | 357.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379825 | - | 1 | 8 | 207_211 | 0 | 307.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000379825 | - | 1 | 8 | 269_270 | 0 | 307.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000397172 | - | 4 | 8 | 207_211 | 103.0 | 285.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000397172 | - | 4 | 8 | 269_270 | 103.0 | 285.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000436040 | - | 1 | 6 | 207_211 | 0 | 445.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000436040 | - | 1 | 6 | 269_270 | 0 | 445.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000463596 | - | 1 | 8 | 207_211 | 0 | 343.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000463596 | - | 1 | 8 | 269_270 | 0 | 343.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000468275 | - | 1 | 8 | 207_211 | 0 | 343.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000468275 | - | 1 | 8 | 269_270 | 0 | 343.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000476858 | - | 1 | 7 | 207_211 | 0 | 303.0 | DNA substrate |
Hgene | APTX | chr9:32987758 | chr10:18961551 | ENST00000476858 | - | 1 | 7 | 269_270 | 0 | 303.0 | DNA substrate |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for APTX-ARL5B |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for APTX-ARL5B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | APTX | C1859598 | ATAXIA, EARLY-ONSET, WITH OCULOMOTOR APRAXIA AND HYPOALBUMINEMIA | 11 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | APTX | C0013421 | Dystonia | 1 | GENOMICS_ENGLAND |
Hgene | APTX | C0598589 | Inherited neuropathies | 1 | GENOMICS_ENGLAND |
Hgene | APTX | C1853761 | SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 1 | 1 | GENOMICS_ENGLAND |
Tgene | C0025202 | melanoma | 1 | CTD_human |