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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHCHD3-EXOC4 (FusionGDB2 ID:HG54927TG60412)

Fusion Gene Summary for CHCHD3-EXOC4

check button Fusion gene summary
Fusion gene informationFusion gene name: CHCHD3-EXOC4
Fusion gene ID: hg54927tg60412
HgeneTgene
Gene symbol

CHCHD3

EXOC4

Gene ID

54927

60412

Gene namecoiled-coil-helix-coiled-coil-helix domain containing 3exocyst complex component 4
SynonymsMICOS19|MINOS3|Mic19|PPP1R22SEC8|SEC8L1|Sec8p
Cytomap('CHCHD3')('EXOC4')

7q32.3-q33

7q33

Type of geneprotein-codingprotein-coding
DescriptionMICOS complex subunit MIC19coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrialmitochondrial contact site and cristae organizing system subunit 19mitochondrial inner membrane organizing system 3protein phosphatase 1, regulatoexocyst complex component 4SEC8-like 1exocyst complex component Sec8
Modification date2020032720200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262570, ENST00000448878, 
ENST00000542753, ENST00000476546, 
ENST00000476546, ENST00000542753, 
ENST00000262570, ENST00000448878, 
Fusion gene scores* DoF score23 X 25 X 10=575035 X 25 X 10=8750
# samples 3139
** MAII scorelog2(31/5750*10)=-4.21322183544486
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(39/8750*10)=-4.48773698785744
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHCHD3 [Title/Abstract] AND EXOC4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHCHD3(132523159)-EXOC4(133502078), # samples:1
CHCHD3(132659925)-EXOC4(133056027), # samples:1
Anticipated loss of major functional domain due to fusion event.CHCHD3-EXOC4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHCHD3-EXOC4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHCHD3

GO:0000122

negative regulation of transcription by RNA polymerase II

22567091


check buttonFusion gene breakpoints across CHCHD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across EXOC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A8IHCHCHD3chr7

132523159

-EXOC4chr7

133502078

+


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Fusion Gene ORF analysis for CHCHD3-EXOC4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000262570ENST00000460346CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
5CDS-3UTRENST00000448878ENST00000460346CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
5CDS-intronENST00000262570ENST00000393161CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
5CDS-intronENST00000262570ENST00000541309CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
5CDS-intronENST00000262570ENST00000545148CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
5CDS-intronENST00000448878ENST00000393161CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
5CDS-intronENST00000448878ENST00000541309CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
5CDS-intronENST00000448878ENST00000545148CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
5UTR-3CDSENST00000476546ENST00000253861CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
5UTR-3CDSENST00000476546ENST00000539845CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
5UTR-3UTRENST00000476546ENST00000460346CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
5UTR-intronENST00000476546ENST00000393161CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
5UTR-intronENST00000476546ENST00000541309CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
5UTR-intronENST00000476546ENST00000545148CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
In-frameENST00000262570ENST00000253861CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
In-frameENST00000262570ENST00000539845CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
In-frameENST00000448878ENST00000253861CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
In-frameENST00000448878ENST00000539845CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
intron-3CDSENST00000542753ENST00000253861CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
intron-3CDSENST00000542753ENST00000539845CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
intron-3UTRENST00000542753ENST00000460346CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
intron-intronENST00000542753ENST00000393161CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
intron-intronENST00000542753ENST00000541309CHCHD3chr7

132523159

-EXOC4chr7

133502078

+
intron-intronENST00000542753ENST00000545148CHCHD3chr7

132523159

-EXOC4chr7

133502078

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000262570CHCHD3chr7132523159-ENST00000253861EXOC4chr7133502078+33116691452079644
ENST00000262570CHCHD3chr7132523159-ENST00000539845EXOC4chr7133502078+21396691452079644
ENST00000448878CHCHD3chr7132523159-ENST00000253861EXOC4chr7133502078+32986561172066649
ENST00000448878CHCHD3chr7132523159-ENST00000539845EXOC4chr7133502078+21266561172066649

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262570ENST00000253861CHCHD3chr7132523159-EXOC4chr7133502078+0.0017926230.99820733
ENST00000262570ENST00000539845CHCHD3chr7132523159-EXOC4chr7133502078+0.0077717730.9922282
ENST00000448878ENST00000253861CHCHD3chr7132523159-EXOC4chr7133502078+0.0018968390.99810314
ENST00000448878ENST00000539845CHCHD3chr7132523159-EXOC4chr7133502078+0.0090147230.9909853

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Fusion Genomic Features for CHCHD3-EXOC4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CHCHD3chr7132523158-EXOC4chr7133502077+2.48E-060.9999975
CHCHD3chr7132523158-EXOC4chr7133502077+2.48E-060.9999975

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CHCHD3-EXOC4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:132523159/chr7:133502078)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEXOC4chr7:132523159chr7:133502078ENST0000039316101032_1140474.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHCHD3chr7:132523159chr7:133502078ENST00000262570-68180_222174228.0DomainCHCH
HgeneCHCHD3chr7:132523159chr7:133502078ENST00000262570-68183_193174228.0MotifCx9C motif 1
HgeneCHCHD3chr7:132523159chr7:133502078ENST00000262570-68204_214174228.0MotifCx9C motif 2
TgeneEXOC4chr7:132523159chr7:133502078ENST0000025386191832_114504975.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for CHCHD3-EXOC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16238_16238_1_CHCHD3-EXOC4_CHCHD3_chr7_132523159_ENST00000262570_EXOC4_chr7_133502078_ENST00000253861_length(transcript)=3311nt_BP=669nt
CGCCTTCTCCTTGCTTCTGGGGGTCGTGGCCTTGCTCCCGCTGTGCGGGAAAAGAATCCAGGCCCTTCCACGCGCGTGTGGGTGCGGGGG
CCCCGAAGTGCTCGTGGTTCCCCGCTAGGTCTCCGCTGGGGCAGGAACCGGAATCATGGGTGGGACCACCAGCACCCGCCGGGTCACCTT
CGAGGCGGACGAGAATGAGAACATCACCGTGGTGAAGGGCATCCGGCTTTCGGAAAATGTGATTGATCGAATGAAGGAATCCTCTCCATC
TGGTTCGAAGTCTCAGCGGTATTCTGGTGCTTATGGTGCCTCAGTTTCTGATGAAGAATTGAAAAGAAGAGTAGCTGAGGAGCTGGCATT
GGAGCAAGCCAAGAAAGAATCCGAAGATCAGAAACGACTAAAGCAAGCCAAAGAGCTGGACCGAGAGAGGGCTGCTGCCAATGAGCAGTT
AACCAGAGCCATCCTTCGGGAGAGGATATGTAGCGAGGAGGAACGCGCTAAGGCAAAGCACCTGGCTAGGCAGCTGGAAGAGAAAGACCG
AGTGCTAAAGAAGCAGGATGCATTCTACAAAGAACAGCTGGCTAGACTGGAGGAGAGGAGCTCAGAGTTCTACAGAGTCACCACTGAACA
ATATCAGAAAGCTGCTGAAGAGGTGGAAGCAAAGTTCAAATTTATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAACAGTG
TCCTCTTCGAGAGTTTCTCACCGTGTACATCAAAAACATCTTTCTCAATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGAGTCAC
TAAAACATCTGACCCTTTGAAGATTCTGGCCAACGCAGACACCATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGAGCACAATCAT
TGTGGAGAAGACAGTTCAAGACCTCCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCT
CCAGGAGTACAAGGACACCTGCACTGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGA
TGATGATATCAGCAGACTCTTGAAATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGA
AGATTTCATAAGGGCAGCTTTTGGCAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCG
TGACGTCAGTGACCTCAAAGCCTTGGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTC
TACATCCCAGATGCTTTCTCCTGCTCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGA
ACTTGCCAAATCGTTCCAGGATATGGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCC
TCTTGCAAAGGAGGGGAACTATGCCATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAG
CGCCATTGAAGAGGCCATGAGCGCCAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCT
CATTAATGGTGCCCAGTACTTCAGGCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGAC
CAACATCACCATGTCGCGGGAGGCAGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCT
GGTGGTGGACCAGGGTGTGAAGTACACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACT
GACCACCCAGAACACGAGGCTGCAGAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAAC
TACCGTTTAGCAGGGCGTACTGCGGTTGGTGACGGGGGTCCCCTCAGTCACACTCACTTTTTTCCTTGGTATGTTATTGAGTATATTCTG
AGCTTAGTTTTCTCTACAGTGATACTTTAGTGGAGAGGAGGTGTAAGGATTCTTTCTCTCTGGTTTTGGCTTTTCATATAAATGCTAAAG
GAAGGCGACAGTACAGAGTGTTTTGGTTGAACAACTACTTTAATGCAGTCAAATCTAACGGGACTAGGGTGGGATAGGGAGGAAGGTGGT
ATCAAATTGTTGGACTCTGAAAAACAAGTGGATGGATTACTAATATTTGATTTATTACTCAATATATATATAATTCCAGCCTTGGAAAGT
AGGAAAGTAGGCTGCTACCTAACTTTTAGTCCCTTCCAAAACCATTTAGTAGGGTTCTATTACATAAACAGTAGGGTTTTTCCTCTCCTG
ACCTTATCCGTTTACAGTTCAATGAAATAAGTGTATGTGCATTGCTGTCTGTCTCTATTGCCAAAATCAAATAAATGGCTTCTCAGCTGC
TGTTTACAACAAACTTCCCTAACCAAAACAGAACCTCTAATTTAGGGCTAGGAATAGAAGTCTTTTGATCCCAGTCCCTGGGACAGTTTT
GTATGCTGTATCTTGTACACAGGTTGTAGGTTGGTTTATTGCCATTTTGTTTTATTTCTGCTGTATAAAAACCAAGAGCCAGACAATTAG
ACAACTATGGAGGAATGAAAGGCAATTCAAACATCTGCTTGATTCCCGCCCCGCCACCCCTAATTTCTGAGAGAATAATGGTTAGAGAAC
ATTGCATCTCACTTGAAACATCCTTTGGGGGTAAATGATTCTTAGGTGCTCACTTGGTCTGAGCTCAGCTGAATGCAGGGAAGATGGGAC
AGAGTGACATTTCTCCTCTGTGCGGCCTCCAGCTGAGCCTGTCTCTGAATTGTTCCCTCCCCCGCAATGTGGGCACTTACCATGTTCCTG
GCACACTGGACCTCACCATGTCCCCCGGTCACCAGTCCTCTTGCTGCCCATGGTTCATAGGTCATAGAAGGCAGCAATGCACTGACTGGG
CCACATCTTGAAAACTCGTGGAAAGGGAAAGGGGAGGAGATGGGACTTTGACCACACACAGTGATGCCTCACACCCTGAAGGTGGGGGAT

>16238_16238_1_CHCHD3-EXOC4_CHCHD3_chr7_132523159_ENST00000262570_EXOC4_chr7_133502078_ENST00000253861_length(amino acids)=644AA_BP=175
MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDEELKRRVAEELALEQAKKESEDQKRLKQAKE
LDRERAAANEQLTRAILRERICSEEERAKAKHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKFIQEI
EHALGLGPAKQCPLREFLTVYIKNIFLNQVLAEINKEIEGVTKTSDPLKILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAY
SDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNL
GDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFSNLSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHL
EVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKM
CRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGVKYTELEYIHALTLLHRSQTGVGELTTQNTRLQRLKEIICEQA

--------------------------------------------------------------
>16238_16238_2_CHCHD3-EXOC4_CHCHD3_chr7_132523159_ENST00000262570_EXOC4_chr7_133502078_ENST00000539845_length(transcript)=2139nt_BP=669nt
CGCCTTCTCCTTGCTTCTGGGGGTCGTGGCCTTGCTCCCGCTGTGCGGGAAAAGAATCCAGGCCCTTCCACGCGCGTGTGGGTGCGGGGG
CCCCGAAGTGCTCGTGGTTCCCCGCTAGGTCTCCGCTGGGGCAGGAACCGGAATCATGGGTGGGACCACCAGCACCCGCCGGGTCACCTT
CGAGGCGGACGAGAATGAGAACATCACCGTGGTGAAGGGCATCCGGCTTTCGGAAAATGTGATTGATCGAATGAAGGAATCCTCTCCATC
TGGTTCGAAGTCTCAGCGGTATTCTGGTGCTTATGGTGCCTCAGTTTCTGATGAAGAATTGAAAAGAAGAGTAGCTGAGGAGCTGGCATT
GGAGCAAGCCAAGAAAGAATCCGAAGATCAGAAACGACTAAAGCAAGCCAAAGAGCTGGACCGAGAGAGGGCTGCTGCCAATGAGCAGTT
AACCAGAGCCATCCTTCGGGAGAGGATATGTAGCGAGGAGGAACGCGCTAAGGCAAAGCACCTGGCTAGGCAGCTGGAAGAGAAAGACCG
AGTGCTAAAGAAGCAGGATGCATTCTACAAAGAACAGCTGGCTAGACTGGAGGAGAGGAGCTCAGAGTTCTACAGAGTCACCACTGAACA
ATATCAGAAAGCTGCTGAAGAGGTGGAAGCAAAGTTCAAATTTATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAACAGTG
TCCTCTTCGAGAGTTTCTCACCGTGTACATCAAAAACATCTTTCTCAATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGAGTCAC
TAAAACATCTGACCCTTTGAAGATTCTGGCCAACGCAGACACCATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGAGCACAATCAT
TGTGGAGAAGACAGTTCAAGACCTCCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCT
CCAGGAGTACAAGGACACCTGCACTGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGA
TGATGATATCAGCAGACTCTTGAAATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGA
AGATTTCATAAGGGCAGCTTTTGGCAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCG
TGACGTCAGTGACCTCAAAGCCTTGGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTC
TACATCCCAGATGCTTTCTCCTGCTCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGA
ACTTGCCAAATCGTTCCAGGATATGGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCC
TCTTGCAAAGGAGGGGAACTATGCCATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAG
CGCCATTGAAGAGGCCATGAGCGCCAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCT
CATTAATGGTGCCCAGTACTTCAGGCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGAC
CAACATCACCATGTCGCGGGAGGCAGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCT
GGTGGTGGACCAGGGTGTGAAGTACACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACT
GACCACCCAGAACACGAGGCTGCAGAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAAC

>16238_16238_2_CHCHD3-EXOC4_CHCHD3_chr7_132523159_ENST00000262570_EXOC4_chr7_133502078_ENST00000539845_length(amino acids)=644AA_BP=175
MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDEELKRRVAEELALEQAKKESEDQKRLKQAKE
LDRERAAANEQLTRAILRERICSEEERAKAKHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKFIQEI
EHALGLGPAKQCPLREFLTVYIKNIFLNQVLAEINKEIEGVTKTSDPLKILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAY
SDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNL
GDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFSNLSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHL
EVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKM
CRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGVKYTELEYIHALTLLHRSQTGVGELTTQNTRLQRLKEIICEQA

--------------------------------------------------------------
>16238_16238_3_CHCHD3-EXOC4_CHCHD3_chr7_132523159_ENST00000448878_EXOC4_chr7_133502078_ENST00000253861_length(transcript)=3298nt_BP=656nt
GCCTTGCTCCCGCTGTGCGGGAAAAGAATCCAGGCCCTTCCACGCGCGTGTGGGTGCGGGGGCCCCGAAGTGCTCGTGGTTCCCCGCTAG
GTCTCCGCTGGGGCAGGAACCGGAATCATGGGTGGGACCACCAGCACCCGCCGGGTCACCTTCGAGGCGGACGAGAATGAGAACATCACC
GTGGTGAAGGGCATCCGGCTTTCGGAAAATGTGATTGATCGAATGAAGGAATCCTCTCCATCTGGTTCGAAGTCTCAGCGGTATTCTGGT
GCTTATGGTGCCTCAGTTTCTGATGAAGAATTGAAAAGAAGAGTAGCTGAGGAGCTGGCATTGGAGCAAGCCAAGAAAGAATCCGAAGAT
CAGAAACGACTAAAGCAAGCCAAAGAGCTGGACCGAGAGAGGGCTGCTGCCAATGAGCAGTTAACCAGAGCCATCCTTCGGGAGAGGATA
TGTAGCGAGGAGGAACGCGCTAAGGCAAAGCACCTGGTGAGTATTAAAAATGCTAGGCAGCTGGAAGAGAAAGACCGAGTGCTAAAGAAG
CAGGATGCATTCTACAAAGAACAGCTGGCTAGACTGGAGGAGAGGAGCTCAGAGTTCTACAGAGTCACCACTGAACAATATCAGAAAGCT
GCTGAAGAGGTGGAAGCAAAGTTCAAATTTATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAACAGTGTCCTCTTCGAGAG
TTTCTCACCGTGTACATCAAAAACATCTTTCTCAATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGAGTCACTAAAACATCTGAC
CCTTTGAAGATTCTGGCCAACGCAGACACCATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGAGCACAATCATTGTGGAGAAGACA
GTTCAAGACCTCCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAGGAGTACAAG
GACACCTGCACTGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGATGATGATATCAGC
AGACTCTTGAAATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGATTTCATAAGG
GCAGCTTTTGGCAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCGTGACGTCAGTGAC
CTCAAAGCCTTGGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACATCCCAGATG
CTTTCTCCTGCTCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGAACTTGCCAAATCG
TTCCAGGATATGGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCCTCTTGCAAAGGAG
GGGAACTATGCCATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAGCGCCATTGAAGAG
GCCATGAGCGCCAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCTCATTAATGGTGCC
CAGTACTTCAGGCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGACCAACATCACCATG
TCGCGGGAGGCAGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTGGTGGACCAG
GGTGTGAAGTACACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACCACCCAGAAC
ACGAGGCTGCAGAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACCGTTTAGCAG
GGCGTACTGCGGTTGGTGACGGGGGTCCCCTCAGTCACACTCACTTTTTTCCTTGGTATGTTATTGAGTATATTCTGAGCTTAGTTTTCT
CTACAGTGATACTTTAGTGGAGAGGAGGTGTAAGGATTCTTTCTCTCTGGTTTTGGCTTTTCATATAAATGCTAAAGGAAGGCGACAGTA
CAGAGTGTTTTGGTTGAACAACTACTTTAATGCAGTCAAATCTAACGGGACTAGGGTGGGATAGGGAGGAAGGTGGTATCAAATTGTTGG
ACTCTGAAAAACAAGTGGATGGATTACTAATATTTGATTTATTACTCAATATATATATAATTCCAGCCTTGGAAAGTAGGAAAGTAGGCT
GCTACCTAACTTTTAGTCCCTTCCAAAACCATTTAGTAGGGTTCTATTACATAAACAGTAGGGTTTTTCCTCTCCTGACCTTATCCGTTT
ACAGTTCAATGAAATAAGTGTATGTGCATTGCTGTCTGTCTCTATTGCCAAAATCAAATAAATGGCTTCTCAGCTGCTGTTTACAACAAA
CTTCCCTAACCAAAACAGAACCTCTAATTTAGGGCTAGGAATAGAAGTCTTTTGATCCCAGTCCCTGGGACAGTTTTGTATGCTGTATCT
TGTACACAGGTTGTAGGTTGGTTTATTGCCATTTTGTTTTATTTCTGCTGTATAAAAACCAAGAGCCAGACAATTAGACAACTATGGAGG
AATGAAAGGCAATTCAAACATCTGCTTGATTCCCGCCCCGCCACCCCTAATTTCTGAGAGAATAATGGTTAGAGAACATTGCATCTCACT
TGAAACATCCTTTGGGGGTAAATGATTCTTAGGTGCTCACTTGGTCTGAGCTCAGCTGAATGCAGGGAAGATGGGACAGAGTGACATTTC
TCCTCTGTGCGGCCTCCAGCTGAGCCTGTCTCTGAATTGTTCCCTCCCCCGCAATGTGGGCACTTACCATGTTCCTGGCACACTGGACCT
CACCATGTCCCCCGGTCACCAGTCCTCTTGCTGCCCATGGTTCATAGGTCATAGAAGGCAGCAATGCACTGACTGGGCCACATCTTGAAA
ACTCGTGGAAAGGGAAAGGGGAGGAGATGGGACTTTGACCACACACAGTGATGCCTCACACCCTGAAGGTGGGGGATTTTGTACCTGTTT

>16238_16238_3_CHCHD3-EXOC4_CHCHD3_chr7_132523159_ENST00000448878_EXOC4_chr7_133502078_ENST00000253861_length(amino acids)=649AA_BP=180
MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDEELKRRVAEELALEQAKKESEDQKRLKQAKE
LDRERAAANEQLTRAILRERICSEEERAKAKHLVSIKNARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFK
FIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQVLAEINKEIEGVTKTSDPLKILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMH
DLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEV
LIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFSNLSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCL
LVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISES
GIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGVKYTELEYIHALTLLHRSQTGVGELTTQNTRLQRLKEI

--------------------------------------------------------------
>16238_16238_4_CHCHD3-EXOC4_CHCHD3_chr7_132523159_ENST00000448878_EXOC4_chr7_133502078_ENST00000539845_length(transcript)=2126nt_BP=656nt
GCCTTGCTCCCGCTGTGCGGGAAAAGAATCCAGGCCCTTCCACGCGCGTGTGGGTGCGGGGGCCCCGAAGTGCTCGTGGTTCCCCGCTAG
GTCTCCGCTGGGGCAGGAACCGGAATCATGGGTGGGACCACCAGCACCCGCCGGGTCACCTTCGAGGCGGACGAGAATGAGAACATCACC
GTGGTGAAGGGCATCCGGCTTTCGGAAAATGTGATTGATCGAATGAAGGAATCCTCTCCATCTGGTTCGAAGTCTCAGCGGTATTCTGGT
GCTTATGGTGCCTCAGTTTCTGATGAAGAATTGAAAAGAAGAGTAGCTGAGGAGCTGGCATTGGAGCAAGCCAAGAAAGAATCCGAAGAT
CAGAAACGACTAAAGCAAGCCAAAGAGCTGGACCGAGAGAGGGCTGCTGCCAATGAGCAGTTAACCAGAGCCATCCTTCGGGAGAGGATA
TGTAGCGAGGAGGAACGCGCTAAGGCAAAGCACCTGGTGAGTATTAAAAATGCTAGGCAGCTGGAAGAGAAAGACCGAGTGCTAAAGAAG
CAGGATGCATTCTACAAAGAACAGCTGGCTAGACTGGAGGAGAGGAGCTCAGAGTTCTACAGAGTCACCACTGAACAATATCAGAAAGCT
GCTGAAGAGGTGGAAGCAAAGTTCAAATTTATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAACAGTGTCCTCTTCGAGAG
TTTCTCACCGTGTACATCAAAAACATCTTTCTCAATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGAGTCACTAAAACATCTGAC
CCTTTGAAGATTCTGGCCAACGCAGACACCATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGAGCACAATCATTGTGGAGAAGACA
GTTCAAGACCTCCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAGGAGTACAAG
GACACCTGCACTGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGATGATGATATCAGC
AGACTCTTGAAATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGATTTCATAAGG
GCAGCTTTTGGCAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCGTGACGTCAGTGAC
CTCAAAGCCTTGGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACATCCCAGATG
CTTTCTCCTGCTCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGAACTTGCCAAATCG
TTCCAGGATATGGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCCTCTTGCAAAGGAG
GGGAACTATGCCATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAGCGCCATTGAAGAG
GCCATGAGCGCCAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCTCATTAATGGTGCC
CAGTACTTCAGGCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGACCAACATCACCATG
TCGCGGGAGGCAGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTGGTGGACCAG
GGTGTGAAGTACACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACCACCCAGAAC
ACGAGGCTGCAGAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACCGTTTAGCAG

>16238_16238_4_CHCHD3-EXOC4_CHCHD3_chr7_132523159_ENST00000448878_EXOC4_chr7_133502078_ENST00000539845_length(amino acids)=649AA_BP=180
MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDEELKRRVAEELALEQAKKESEDQKRLKQAKE
LDRERAAANEQLTRAILRERICSEEERAKAKHLVSIKNARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFK
FIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQVLAEINKEIEGVTKTSDPLKILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMH
DLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEV
LIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFSNLSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCL
LVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISES
GIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGVKYTELEYIHALTLLHRSQTGVGELTTQNTRLQRLKEI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CHCHD3-EXOC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHCHD3-EXOC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHCHD3-EXOC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHCHD3C0013146Drug abuse1CTD_human
HgeneCHCHD3C0013170Drug habituation1CTD_human
HgeneCHCHD3C0013222Drug Use Disorders1CTD_human
HgeneCHCHD3C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneCHCHD3C0038580Substance Dependence1CTD_human
HgeneCHCHD3C0038586Substance Use Disorders1CTD_human
HgeneCHCHD3C0236969Substance-Related Disorders1CTD_human
HgeneCHCHD3C0740858Substance abuse problem1CTD_human
HgeneCHCHD3C1510472Drug Dependence1CTD_human
HgeneCHCHD3C4316881Prescription Drug Abuse1CTD_human