Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ATG16L1-ACSL3 (FusionGDB2 ID:HG55054TG2181)

Fusion Gene Summary for ATG16L1-ACSL3

check button Fusion gene summary
Fusion gene informationFusion gene name: ATG16L1-ACSL3
Fusion gene ID: hg55054tg2181
HgeneTgene
Gene symbol

ATG16L1

ACSL3

Gene ID

55054

2181

Gene nameautophagy related 16 like 1acyl-CoA synthetase long chain family member 3
SynonymsAPG16L|ATG16A|ATG16L|IBD10|WDR30ACS3|FACL3|LACS 3|LACS3|PRO2194
Cytomap('ATG16L1')('ACSL3')

2q37.1

2q36.1

Type of geneprotein-codingprotein-coding
Descriptionautophagy-related protein 16-1APG16L betaATG16 autophagy related 16-like 1WD repeat domain 30long-chain-fatty-acid--CoA ligase 3arachidonate--CoA ligasefatty-acid-Coenzyme A ligase, long-chain 3lignoceroyl-CoA synthaselong-chain acyl-CoA synthetase 3
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000347464, ENST00000373525, 
ENST00000392017, ENST00000392018, 
ENST00000392020, ENST00000498620, 
Fusion gene scores* DoF score5 X 4 X 4=807 X 6 X 5=210
# samples 57
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATG16L1 [Title/Abstract] AND ACSL3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATG16L1(234164841)-ACSL3(223806215), # samples:1
Anticipated loss of major functional domain due to fusion event.ATG16L1-ACSL3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATG16L1-ACSL3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATG16L1-ACSL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATG16L1-ACSL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATG16L1-ACSL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ATG16L1-ACSL3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ATG16L1-ACSL3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ATG16L1-ACSL3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACSL3

GO:0044539

long-chain fatty acid import

20219900


check buttonFusion gene breakpoints across ATG16L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ACSL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GH-01AATG16L1chr2

234164841

+ACSL3chr2

223806215

+


Top

Fusion Gene ORF analysis for ATG16L1-ACSL3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000347464ENST00000357430ATG16L1chr2

234164841

+ACSL3chr2

223806215

+
Frame-shiftENST00000373525ENST00000357430ATG16L1chr2

234164841

+ACSL3chr2

223806215

+
Frame-shiftENST00000392017ENST00000357430ATG16L1chr2

234164841

+ACSL3chr2

223806215

+
Frame-shiftENST00000392018ENST00000357430ATG16L1chr2

234164841

+ACSL3chr2

223806215

+
Frame-shiftENST00000392020ENST00000357430ATG16L1chr2

234164841

+ACSL3chr2

223806215

+
In-frameENST00000347464ENST00000392066ATG16L1chr2

234164841

+ACSL3chr2

223806215

+
In-frameENST00000373525ENST00000392066ATG16L1chr2

234164841

+ACSL3chr2

223806215

+
In-frameENST00000392017ENST00000392066ATG16L1chr2

234164841

+ACSL3chr2

223806215

+
In-frameENST00000392018ENST00000392066ATG16L1chr2

234164841

+ACSL3chr2

223806215

+
In-frameENST00000392020ENST00000392066ATG16L1chr2

234164841

+ACSL3chr2

223806215

+
intron-3CDSENST00000498620ENST00000357430ATG16L1chr2

234164841

+ACSL3chr2

223806215

+
intron-3CDSENST00000498620ENST00000392066ATG16L1chr2

234164841

+ACSL3chr2

223806215

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000347464ATG16L1chr2234164841+ENST00000392066ACSL3chr2223806215+11924663781125
ENST00000392017ATG16L1chr2234164841+ENST00000392066ACSL3chr2223806215+11924663781125
ENST00000373525ATG16L1chr2234164841+ENST00000392066ACSL3chr2223806215+1091365497868123
ENST00000392020ATG16L1chr2234164841+ENST00000392066ACSL3chr2223806215+1057331463834123
ENST00000392018ATG16L1chr2234164841+ENST00000392066ACSL3chr2223806215+1049323455826123

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000347464ENST00000392066ATG16L1chr2234164841+ACSL3chr2223806215+0.211673360.7883266
ENST00000392017ENST00000392066ATG16L1chr2234164841+ACSL3chr2223806215+0.211673360.7883266
ENST00000373525ENST00000392066ATG16L1chr2234164841+ACSL3chr2223806215+0.22193350.7780665
ENST00000392020ENST00000392066ATG16L1chr2234164841+ACSL3chr2223806215+0.247079950.7529201
ENST00000392018ENST00000392066ATG16L1chr2234164841+ACSL3chr2223806215+0.223246280.7767537

Top

Fusion Genomic Features for ATG16L1-ACSL3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATG16L1chr2234164841+ACSL3chr2223806214+5.66E-050.9999435
ATG16L1chr2234164841+ACSL3chr2223806214+5.66E-050.9999435

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ATG16L1-ACSL3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:234164841/chr2:223806215)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATG16L1chr2:234164841chr2:223806215ENST00000347464+21478_23069445.0Coiled coilOntology_term=ECO:0000255
HgeneATG16L1chr2:234164841chr2:223806215ENST00000373525+21578_23069429.0Coiled coilOntology_term=ECO:0000255
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392017+21878_23069608.0Coiled coilOntology_term=ECO:0000255
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392020+21778_23069589.0Coiled coilOntology_term=ECO:0000255
HgeneATG16L1chr2:234164841chr2:223806215ENST00000347464+214296_29969445.0MotifNote=Caspase cleavage
HgeneATG16L1chr2:234164841chr2:223806215ENST00000373525+215296_29969429.0MotifNote=Caspase cleavage
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392017+218296_29969608.0MotifNote=Caspase cleavage
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392020+217296_29969589.0MotifNote=Caspase cleavage
HgeneATG16L1chr2:234164841chr2:223806215ENST00000347464+214207_23069445.0RegionWIPI2-binding
HgeneATG16L1chr2:234164841chr2:223806215ENST00000347464+214230_24269445.0RegionRB1CC1-binding
HgeneATG16L1chr2:234164841chr2:223806215ENST00000373525+215207_23069429.0RegionWIPI2-binding
HgeneATG16L1chr2:234164841chr2:223806215ENST00000373525+215230_24269429.0RegionRB1CC1-binding
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392017+218207_23069608.0RegionWIPI2-binding
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392017+218230_24269608.0RegionRB1CC1-binding
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392020+217207_23069589.0RegionWIPI2-binding
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392020+217230_24269589.0RegionRB1CC1-binding
HgeneATG16L1chr2:234164841chr2:223806215ENST00000347464+214320_35969445.0RepeatWD 1
HgeneATG16L1chr2:234164841chr2:223806215ENST00000347464+214364_40369445.0RepeatWD 2
HgeneATG16L1chr2:234164841chr2:223806215ENST00000347464+214406_44569445.0RepeatWD 3
HgeneATG16L1chr2:234164841chr2:223806215ENST00000347464+214447_48469445.0RepeatWD 4
HgeneATG16L1chr2:234164841chr2:223806215ENST00000347464+214486_52569445.0RepeatWD 5
HgeneATG16L1chr2:234164841chr2:223806215ENST00000347464+214532_57369445.0RepeatWD 6
HgeneATG16L1chr2:234164841chr2:223806215ENST00000347464+214575_60769445.0RepeatWD 7
HgeneATG16L1chr2:234164841chr2:223806215ENST00000373525+215320_35969429.0RepeatWD 1
HgeneATG16L1chr2:234164841chr2:223806215ENST00000373525+215364_40369429.0RepeatWD 2
HgeneATG16L1chr2:234164841chr2:223806215ENST00000373525+215406_44569429.0RepeatWD 3
HgeneATG16L1chr2:234164841chr2:223806215ENST00000373525+215447_48469429.0RepeatWD 4
HgeneATG16L1chr2:234164841chr2:223806215ENST00000373525+215486_52569429.0RepeatWD 5
HgeneATG16L1chr2:234164841chr2:223806215ENST00000373525+215532_57369429.0RepeatWD 6
HgeneATG16L1chr2:234164841chr2:223806215ENST00000373525+215575_60769429.0RepeatWD 7
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392017+218320_35969608.0RepeatWD 1
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392017+218364_40369608.0RepeatWD 2
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392017+218406_44569608.0RepeatWD 3
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392017+218447_48469608.0RepeatWD 4
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392017+218486_52569608.0RepeatWD 5
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392017+218532_57369608.0RepeatWD 6
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392017+218575_60769608.0RepeatWD 7
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392020+217320_35969589.0RepeatWD 1
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392020+217364_40369589.0RepeatWD 2
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392020+217406_44569589.0RepeatWD 3
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392020+217447_48469589.0RepeatWD 4
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392020+217486_52569589.0RepeatWD 5
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392020+217532_57369589.0RepeatWD 6
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392020+217575_60769589.0RepeatWD 7
TgeneACSL3chr2:234164841chr2:223806215ENST00000357430151742_720668721.0Topological domainCytoplasmic
TgeneACSL3chr2:234164841chr2:223806215ENST00000392066141642_720668721.0Topological domainCytoplasmic
TgeneACSL3chr2:234164841chr2:223806215ENST00000357430151721_41668721.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
TgeneACSL3chr2:234164841chr2:223806215ENST00000392066141621_41668721.0TransmembraneHelical%3B Signal-anchor for type III membrane protein


Top

Fusion Gene Sequence for ATG16L1-ACSL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7533_7533_1_ATG16L1-ACSL3_ATG16L1_chr2_234164841_ENST00000347464_ACSL3_chr2_223806215_ENST00000392066_length(transcript)=1192nt_BP=466nt
ACTAGCGAGCGCCCTGCGTAGGCACCGGCTCCTGAGCCCGTGCTTCGGGTGAGGGGGCGGGTCTTCCGGCCCTCTCGAAAATCATTTCCG
GCATGAGCCGGAAGACCGTCCCGGATGGCCTCGGGGACTGCCAGTGTGTGGAGGTGAGCTCCGGGATTGCCGGCATTCCCGCTTCTGCTG
GTTGCTTCATGCTGCAGGCTGCGGCCGTCAGCCCTCGCTCGCATTGGTGGCGCTGAGGTGCCGGGGCAGCAAGTGACATGTCGTCGGGCC
TCCGCGCCGCTGACTTCCCCCGCTGGAAGCGCCACATCTCGGAGCAACTGAGGCGCCGGGACCGGCTGCAGAGACAGGCGTTCGAGGAGA
TCATCCTGCAGTATAACAAATTGCTGGAAAAGTCAGATCTTCATTCAGTGTTGGCCCAGAAACTACAGGCTGAAAAGCATGACGTACCAA
ACAGGCACGAGATAAGCAAGTCTGGAAAAGTTTGAAATTCCAGTAAAAATTCGTTTGAGTCCTGAACCGTGGACCCCTGAAACTGGTCTG
GTGACAGATGCCTTCAAGCTGAAACGCAAAGAGCTTAAAACACATTACCAGGCGGACATTGAGCGAATGTATGGAAGAAAATAATTATTC
TCTTCTGGCATCAGTTTGCTACAGTGAGCTCAGATCAAATAGGAAAATACTTGAAATGCATGTCTCAAGCTGCAAGGCAAACTCCATTCC
TCATATTAAACTATTACTTCTCATGACGTCACCATTTTTAACTGACAGGATTAGTAAAACATTAAGACAGCAAACTTGTGTCTGTCTCTT
CTTTCATTTTCCCCGCCACCAACTTACTTTACCACCTATGACTGTACTTGTCAGTATGAGAATTTTTCTGAATCATATTGGGGAAGCAGT
GATTTTAAAACCTCAAGTTTTTAAACATGATTTATATGTTCTGTATAATGTTCAGTTTGTAACTTTTTAAAAGTTTGGATGTATAGAGGG
ATAAATAGGAAATATAAGAATTGGTTATTTGGGGGCTTTTTTACTTACTGTATTTAAAAATACAAGGGTATTGATATGAAATTATGTAAA
TTTCAAATGCTTATGAATCAAATCATTGTTGAACAAAAGATTTGTTGCTGTGTAATTATTGTCTTGTATGCATTTGAGAGAAATAAATAT

>7533_7533_1_ATG16L1-ACSL3_ATG16L1_chr2_234164841_ENST00000347464_ACSL3_chr2_223806215_ENST00000392066_length(amino acids)=125AA_BP=
MLYCRMISSNACLCSRSRRLSCSEMWRFQRGKSAARRPDDMSLAAPAPQRHQCERGLTAAACSMKQPAEAGMPAIPELTSTHWQSPRPSG

--------------------------------------------------------------
>7533_7533_2_ATG16L1-ACSL3_ATG16L1_chr2_234164841_ENST00000373525_ACSL3_chr2_223806215_ENST00000392066_length(transcript)=1091nt_BP=365nt
AAGACCGTCCCGGATGGCCTCGGGGACTGCCAGTGTGTGGAGGTGAGCTCCGGGATTGCCGGCATTCCCGCTTCTGCTGGTTGCTTCATG
CTGCAGGCTGCGGCCGTCAGCCCTCGCTCGCATTGGTGGCGCTGAGGTGCCGGGGCAGCAAGTGACATGTCGTCGGGCCTCCGCGCCGCT
GACTTCCCCCGCTGGAAGCGCCACATCTCGGAGCAACTGAGGCGCCGGGACCGGCTGCAGAGACAGGCGTTCGAGGAGATCATCCTGCAG
TATAACAAATTGCTGGAAAAGTCAGATCTTCATTCAGTGTTGGCCCAGAAACTACAGGCTGAAAAGCATGACGTACCAAACAGGCACGAG
ATAAGCAAGTCTGGAAAAGTTTGAAATTCCAGTAAAAATTCGTTTGAGTCCTGAACCGTGGACCCCTGAAACTGGTCTGGTGACAGATGC
CTTCAAGCTGAAACGCAAAGAGCTTAAAACACATTACCAGGCGGACATTGAGCGAATGTATGGAAGAAAATAATTATTCTCTTCTGGCAT
CAGTTTGCTACAGTGAGCTCAGATCAAATAGGAAAATACTTGAAATGCATGTCTCAAGCTGCAAGGCAAACTCCATTCCTCATATTAAAC
TATTACTTCTCATGACGTCACCATTTTTAACTGACAGGATTAGTAAAACATTAAGACAGCAAACTTGTGTCTGTCTCTTCTTTCATTTTC
CCCGCCACCAACTTACTTTACCACCTATGACTGTACTTGTCAGTATGAGAATTTTTCTGAATCATATTGGGGAAGCAGTGATTTTAAAAC
CTCAAGTTTTTAAACATGATTTATATGTTCTGTATAATGTTCAGTTTGTAACTTTTTAAAAGTTTGGATGTATAGAGGGATAAATAGGAA
ATATAAGAATTGGTTATTTGGGGGCTTTTTTACTTACTGTATTTAAAAATACAAGGGTATTGATATGAAATTATGTAAATTTCAAATGCT
TATGAATCAAATCATTGTTGAACAAAAGATTTGTTGCTGTGTAATTATTGTCTTGTATGCATTTGAGAGAAATAAATATACCCATACTTA

>7533_7533_2_ATG16L1-ACSL3_ATG16L1_chr2_234164841_ENST00000373525_ACSL3_chr2_223806215_ENST00000392066_length(amino acids)=123AA_BP=
MSECMEENNYSLLASVCYSELRSNRKILEMHVSSCKANSIPHIKLLLLMTSPFLTDRISKTLRQQTCVCLFFHFPRHQLTLPPMTVLVSM

--------------------------------------------------------------
>7533_7533_3_ATG16L1-ACSL3_ATG16L1_chr2_234164841_ENST00000392017_ACSL3_chr2_223806215_ENST00000392066_length(transcript)=1192nt_BP=466nt
ACTAGCGAGCGCCCTGCGTAGGCACCGGCTCCTGAGCCCGTGCTTCGGGTGAGGGGGCGGGTCTTCCGGCCCTCTCGAAAATCATTTCCG
GCATGAGCCGGAAGACCGTCCCGGATGGCCTCGGGGACTGCCAGTGTGTGGAGGTGAGCTCCGGGATTGCCGGCATTCCCGCTTCTGCTG
GTTGCTTCATGCTGCAGGCTGCGGCCGTCAGCCCTCGCTCGCATTGGTGGCGCTGAGGTGCCGGGGCAGCAAGTGACATGTCGTCGGGCC
TCCGCGCCGCTGACTTCCCCCGCTGGAAGCGCCACATCTCGGAGCAACTGAGGCGCCGGGACCGGCTGCAGAGACAGGCGTTCGAGGAGA
TCATCCTGCAGTATAACAAATTGCTGGAAAAGTCAGATCTTCATTCAGTGTTGGCCCAGAAACTACAGGCTGAAAAGCATGACGTACCAA
ACAGGCACGAGATAAGCAAGTCTGGAAAAGTTTGAAATTCCAGTAAAAATTCGTTTGAGTCCTGAACCGTGGACCCCTGAAACTGGTCTG
GTGACAGATGCCTTCAAGCTGAAACGCAAAGAGCTTAAAACACATTACCAGGCGGACATTGAGCGAATGTATGGAAGAAAATAATTATTC
TCTTCTGGCATCAGTTTGCTACAGTGAGCTCAGATCAAATAGGAAAATACTTGAAATGCATGTCTCAAGCTGCAAGGCAAACTCCATTCC
TCATATTAAACTATTACTTCTCATGACGTCACCATTTTTAACTGACAGGATTAGTAAAACATTAAGACAGCAAACTTGTGTCTGTCTCTT
CTTTCATTTTCCCCGCCACCAACTTACTTTACCACCTATGACTGTACTTGTCAGTATGAGAATTTTTCTGAATCATATTGGGGAAGCAGT
GATTTTAAAACCTCAAGTTTTTAAACATGATTTATATGTTCTGTATAATGTTCAGTTTGTAACTTTTTAAAAGTTTGGATGTATAGAGGG
ATAAATAGGAAATATAAGAATTGGTTATTTGGGGGCTTTTTTACTTACTGTATTTAAAAATACAAGGGTATTGATATGAAATTATGTAAA
TTTCAAATGCTTATGAATCAAATCATTGTTGAACAAAAGATTTGTTGCTGTGTAATTATTGTCTTGTATGCATTTGAGAGAAATAAATAT

>7533_7533_3_ATG16L1-ACSL3_ATG16L1_chr2_234164841_ENST00000392017_ACSL3_chr2_223806215_ENST00000392066_length(amino acids)=125AA_BP=
MLYCRMISSNACLCSRSRRLSCSEMWRFQRGKSAARRPDDMSLAAPAPQRHQCERGLTAAACSMKQPAEAGMPAIPELTSTHWQSPRPSG

--------------------------------------------------------------
>7533_7533_4_ATG16L1-ACSL3_ATG16L1_chr2_234164841_ENST00000392018_ACSL3_chr2_223806215_ENST00000392066_length(transcript)=1049nt_BP=323nt
GTGAGCTCCGGGATTGCCGGCATTCCCGCTTCTGCTGGTTGCTTCATGCTGCAGGCTGCGGCCGTCAGCCCTCGCTCGCATTGGTGGCGC
TGAGGTGCCGGGGCAGCAAGTGACATGTCGTCGGGCCTCCGCGCCGCTGACTTCCCCCGCTGGAAGCGCCACATCTCGGAGCAACTGAGG
CGCCGGGACCGGCTGCAGAGACAGGCGTTCGAGGAGATCATCCTGCAGTATAACAAATTGCTGGAAAAGTCAGATCTTCATTCAGTGTTG
GCCCAGAAACTACAGGCTGAAAAGCATGACGTACCAAACAGGCACGAGATAAGCAAGTCTGGAAAAGTTTGAAATTCCAGTAAAAATTCG
TTTGAGTCCTGAACCGTGGACCCCTGAAACTGGTCTGGTGACAGATGCCTTCAAGCTGAAACGCAAAGAGCTTAAAACACATTACCAGGC
GGACATTGAGCGAATGTATGGAAGAAAATAATTATTCTCTTCTGGCATCAGTTTGCTACAGTGAGCTCAGATCAAATAGGAAAATACTTG
AAATGCATGTCTCAAGCTGCAAGGCAAACTCCATTCCTCATATTAAACTATTACTTCTCATGACGTCACCATTTTTAACTGACAGGATTA
GTAAAACATTAAGACAGCAAACTTGTGTCTGTCTCTTCTTTCATTTTCCCCGCCACCAACTTACTTTACCACCTATGACTGTACTTGTCA
GTATGAGAATTTTTCTGAATCATATTGGGGAAGCAGTGATTTTAAAACCTCAAGTTTTTAAACATGATTTATATGTTCTGTATAATGTTC
AGTTTGTAACTTTTTAAAAGTTTGGATGTATAGAGGGATAAATAGGAAATATAAGAATTGGTTATTTGGGGGCTTTTTTACTTACTGTAT
TTAAAAATACAAGGGTATTGATATGAAATTATGTAAATTTCAAATGCTTATGAATCAAATCATTGTTGAACAAAAGATTTGTTGCTGTGT

>7533_7533_4_ATG16L1-ACSL3_ATG16L1_chr2_234164841_ENST00000392018_ACSL3_chr2_223806215_ENST00000392066_length(amino acids)=123AA_BP=
MSECMEENNYSLLASVCYSELRSNRKILEMHVSSCKANSIPHIKLLLLMTSPFLTDRISKTLRQQTCVCLFFHFPRHQLTLPPMTVLVSM

--------------------------------------------------------------
>7533_7533_5_ATG16L1-ACSL3_ATG16L1_chr2_234164841_ENST00000392020_ACSL3_chr2_223806215_ENST00000392066_length(transcript)=1057nt_BP=331nt
GTGTGGAGGTGAGCTCCGGGATTGCCGGCATTCCCGCTTCTGCTGGTTGCTTCATGCTGCAGGCTGCGGCCGTCAGCCCTCGCTCGCATT
GGTGGCGCTGAGGTGCCGGGGCAGCAAGTGACATGTCGTCGGGCCTCCGCGCCGCTGACTTCCCCCGCTGGAAGCGCCACATCTCGGAGC
AACTGAGGCGCCGGGACCGGCTGCAGAGACAGGCGTTCGAGGAGATCATCCTGCAGTATAACAAATTGCTGGAAAAGTCAGATCTTCATT
CAGTGTTGGCCCAGAAACTACAGGCTGAAAAGCATGACGTACCAAACAGGCACGAGATAAGCAAGTCTGGAAAAGTTTGAAATTCCAGTA
AAAATTCGTTTGAGTCCTGAACCGTGGACCCCTGAAACTGGTCTGGTGACAGATGCCTTCAAGCTGAAACGCAAAGAGCTTAAAACACAT
TACCAGGCGGACATTGAGCGAATGTATGGAAGAAAATAATTATTCTCTTCTGGCATCAGTTTGCTACAGTGAGCTCAGATCAAATAGGAA
AATACTTGAAATGCATGTCTCAAGCTGCAAGGCAAACTCCATTCCTCATATTAAACTATTACTTCTCATGACGTCACCATTTTTAACTGA
CAGGATTAGTAAAACATTAAGACAGCAAACTTGTGTCTGTCTCTTCTTTCATTTTCCCCGCCACCAACTTACTTTACCACCTATGACTGT
ACTTGTCAGTATGAGAATTTTTCTGAATCATATTGGGGAAGCAGTGATTTTAAAACCTCAAGTTTTTAAACATGATTTATATGTTCTGTA
TAATGTTCAGTTTGTAACTTTTTAAAAGTTTGGATGTATAGAGGGATAAATAGGAAATATAAGAATTGGTTATTTGGGGGCTTTTTTACT
TACTGTATTTAAAAATACAAGGGTATTGATATGAAATTATGTAAATTTCAAATGCTTATGAATCAAATCATTGTTGAACAAAAGATTTGT

>7533_7533_5_ATG16L1-ACSL3_ATG16L1_chr2_234164841_ENST00000392020_ACSL3_chr2_223806215_ENST00000392066_length(amino acids)=123AA_BP=
MSECMEENNYSLLASVCYSELRSNRKILEMHVSSCKANSIPHIKLLLLMTSPFLTDRISKTLRQQTCVCLFFHFPRHQLTLPPMTVLVSM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ATG16L1-ACSL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneATG16L1chr2:234164841chr2:223806215ENST00000347464+21413_4369.66666666666667445.0ATG5
HgeneATG16L1chr2:234164841chr2:223806215ENST00000373525+21513_4369.66666666666667429.0ATG5
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392017+21813_4369.66666666666667608.0ATG5
HgeneATG16L1chr2:234164841chr2:223806215ENST00000392020+21713_4369.66666666666667589.0ATG5


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ATG16L1-ACSL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ATG16L1-ACSL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATG16L1C1970207Inflammatory Bowel Disease 1011CTD_human;UNIPROT
HgeneATG16L1C0010346Crohn Disease2CTD_human;GENOMICS_ENGLAND
HgeneATG16L1C0156147Crohn's disease of large bowel2CTD_human
HgeneATG16L1C0267380Crohn's disease of the ileum2CTD_human
HgeneATG16L1C0678202Regional enteritis2CTD_human
HgeneATG16L1C0949272IIeocolitis2CTD_human
HgeneATG16L1C0021390Inflammatory Bowel Diseases1CTD_human