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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATG2B-SAMD13 (FusionGDB2 ID:HG55102TG148418)

Fusion Gene Summary for ATG2B-SAMD13

check button Fusion gene summary
Fusion gene informationFusion gene name: ATG2B-SAMD13
Fusion gene ID: hg55102tg148418
HgeneTgene
Gene symbol

ATG2B

SAMD13

Gene ID

55102

148418

Gene nameautophagy related 2Bsterile alpha motif domain containing 13
SynonymsC14orf103HSD-41|HSD-42
Cytomap('ATG2B')('SAMD13')

14q32.2

1p31.1

Type of geneprotein-codingprotein-coding
Descriptionautophagy-related protein 2 homolog BATG2 autophagy related 2 homolog Bsterile alpha motif domain-containing protein 13SAM domain-containing protein 13dnaj-like protein (LOC148418)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000359933, ENST00000261834, 
Fusion gene scores* DoF score5 X 5 X 5=1254 X 4 X 4=64
# samples 54
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATG2B [Title/Abstract] AND SAMD13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATG2B(96807859)-SAMD13(84815314), # samples:1
Anticipated loss of major functional domain due to fusion event.ATG2B-SAMD13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATG2B-SAMD13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATG2B-SAMD13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATG2B-SAMD13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATG2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SAMD13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8078-01AATG2Bchr14

96807859

-SAMD13chr1

84815314

+


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Fusion Gene ORF analysis for ATG2B-SAMD13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000359933ENST00000370668ATG2Bchr14

96807859

-SAMD13chr1

84815314

+
Frame-shiftENST00000359933ENST00000370669ATG2Bchr14

96807859

-SAMD13chr1

84815314

+
Frame-shiftENST00000359933ENST00000370671ATG2Bchr14

96807859

-SAMD13chr1

84815314

+
Frame-shiftENST00000359933ENST00000370673ATG2Bchr14

96807859

-SAMD13chr1

84815314

+
Frame-shiftENST00000359933ENST00000394834ATG2Bchr14

96807859

-SAMD13chr1

84815314

+
In-frameENST00000359933ENST00000370667ATG2Bchr14

96807859

-SAMD13chr1

84815314

+
In-frameENST00000359933ENST00000370670ATG2Bchr14

96807859

-SAMD13chr1

84815314

+
intron-3CDSENST00000261834ENST00000370667ATG2Bchr14

96807859

-SAMD13chr1

84815314

+
intron-3CDSENST00000261834ENST00000370668ATG2Bchr14

96807859

-SAMD13chr1

84815314

+
intron-3CDSENST00000261834ENST00000370669ATG2Bchr14

96807859

-SAMD13chr1

84815314

+
intron-3CDSENST00000261834ENST00000370670ATG2Bchr14

96807859

-SAMD13chr1

84815314

+
intron-3CDSENST00000261834ENST00000370671ATG2Bchr14

96807859

-SAMD13chr1

84815314

+
intron-3CDSENST00000261834ENST00000370673ATG2Bchr14

96807859

-SAMD13chr1

84815314

+
intron-3CDSENST00000261834ENST00000394834ATG2Bchr14

96807859

-SAMD13chr1

84815314

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359933ATG2Bchr1496807859-ENST00000370670SAMD13chr184815314+211818188161961381
ENST00000359933ATG2Bchr1496807859-ENST00000370667SAMD13chr184815314+298518188161961381

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359933ENST00000370670ATG2Bchr1496807859-SAMD13chr184815314+0.0083350140.99166495
ENST00000359933ENST00000370667ATG2Bchr1496807859-SAMD13chr184815314+0.0026097230.99739033

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Fusion Genomic Features for ATG2B-SAMD13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATG2Bchr1496807858-SAMD13chr184815313+0.0579548370.94204515
ATG2Bchr1496807858-SAMD13chr184815313+0.0579548370.94204515

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATG2B-SAMD13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:96807859/chr1:84815314)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSAMD13chr14:96807859chr1:84815314ENST000003706670251_1194593.0DomainSAM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSAMD13chr14:96807859chr1:84815314ENST000003706682451_11955103.0DomainSAM
TgeneSAMD13chr14:96807859chr1:84815314ENST000003706692451_11955103.0DomainSAM
TgeneSAMD13chr14:96807859chr1:84815314ENST000003706702451_11955103.0DomainSAM
TgeneSAMD13chr14:96807859chr1:84815314ENST000003706712451_11975123.0DomainSAM
TgeneSAMD13chr14:96807859chr1:84815314ENST000003706732451_11969117.0DomainSAM
TgeneSAMD13chr14:96807859chr1:84815314ENST000003948342451_11955103.0DomainSAM


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Fusion Gene Sequence for ATG2B-SAMD13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7553_7553_1_ATG2B-SAMD13_ATG2B_chr14_96807859_ENST00000359933_SAMD13_chr1_84815314_ENST00000370667_length(transcript)=2985nt_BP=1818nt
GGTGCGGGCGGGGATGCTCGAGAAGGGCTCCAGTCCTCCCAGCGGAGACGGCGGAGCCCCAAGTGTGCGTTTCCGGGGCGCCGAGGTCTG
AGGGGAGCCGGGAGAGCCAGGCCGGCCAGACCGGCCCCCAGACCCCTCTTAACACGGGCGCGGGGCCCCTGCAGCCTGCCGCCCCTCTCG
GCCCAGCCAGCTGCATGGCGTCGCGTCCCCATCCGGAAGGCCTGACGGCCCGCCGGCGCCCCGAGCCCCTAGCCCTTCTCGGGGGCCGCC
CCTCGCCCGCAGCCACCCCGGCTGCCGCTCACCTGCGCGCCCGGCGTCCTCTTCTTCCTTCCTCCGGAGGCGACTGGAGCCGACCGGCGG
TGCCGCCCCCTCCCTCCCCGCCTTCTTCCGCCCCGCCCCCTCGGAGCCGGAACTGCTCCAGCCCCCGCCCTTCTGCCCGCCTTCCGCGGC
CCCAGTGTGGCGTCACTTCCGCCAGCGCCCGGCGGCGCGCCGGGAGTCTGGGTCTCGTGAACGCGCCAGGAGCGTCCCTACAGCCGGGAA
CGCGCCTCGCGGATGACAACAAATTCGTCGCGCGGCGGCAGTGGCGGTGGCTGCCTCAGCCCCTGCCGCCTCCTCTCGCGCTCTCTTGCA
CTCTCTCCGAGCCGGTTGGGACCCTCCTCGGAAGTCCCCTGGCCTGGGGCCAGGAGGACCCCTCTGCGTCTTGCCTCCGCCAGGCCCAGC
GCGAGCGGTGCGGCGCCGGCGATGGGGTCTCCCTGAGGGACTCCCGGCACCAAATAGGGATGGAGGGGCCGCCCCAGGCTTAGGCCCCGC
CGCGGCCTGGAGCCGGAGTCGCTACCCCGAGGCCGGAGCCGTCGCAACCCGCAGCCGCAGTCAGCCCAGCTGCCAGCAGTCACTATGCCT
TGGCCGTTTTCGGAGTCCATCAAGAAGAGGGCCTGCCGGTACCTCCTGCAGAGGTACCTGGGCCACTTTCTGCAGGAGAAGCTGAGCCTG
GAGCAGCTCAGCCTGGACCTGTACCAAGGCACCGGGTCCCTCGCCCAGGTCCCCTTGGACAAATGGTGTCTCAATGAGATCTTGGAGTCA
GCAGATGCACCCTTAGAAGTCACTGAAGGATTCATTCAGTCAATTTCCCTGTCAGTTCCATGGGGCTCTTTACTGCAGGATAATTGTGCA
CTGGAAGTGAGAGGATTAGAAATGGTCTTCCGGCCTAGACCTCGCCCAGCAACTGGTTCTGAGCCTATGTATTGGTCAAGTTTTATGACC
AGCAGTATGCAATTGGCAAAAGAATGTCTTAGCCAGAAACTAACAGATGAACAAGGAGAAGGATCCCAGCCTTTTGAAGGACTTGAAAAG
TTTGCTGAAACCATTGAAACAGTACTAAGAAGAGTAAAAGTCACTTTTATAGATACTGTTTTGAGAATTGAACATGTGCCAGAAAATTCC
AAAACTGGAACTGCACTTGAAATTCGAATAGAAAGAACTGTGTACTGTGATGAAACTGCTGACGAATCCTCAGGAATTAATGTGCATCAA
CCCACTGCTTTTGCTCACAAGTTACTTCAGCTCTCTGGAGTGTCTCTCTTCTGGGATGAGTTTTCTGCATCAGCCAAATCTTCCCCAGTG
TGTTCAACTGCACCAGTGGAAACTGAGCCAAAGCTCTCACCTAGCTGGAACCCCAAAATTATTTATGAGCCACACCCACAGCTAACTAGA
AATTTACCAGAGATAGCACCTTCTGACCCAGTGCAGATTGGACGGTTAATTGGTAGGTTGGAGTTGAGTCTCACGTTGAAACAGAATGAA
GTGCTTCCTGGAGCTAAGGAAATTGATGGAAAATCCCTGCTATTGATGACAAGAAATGATGTGTTGACAGGACTTCAGTTAAAATTGGGG
CCTGCTCTGAAAATCTACGAATATCATGTAAAACCTCTGCAGACAAAGCATTTAAAGAACAACTCTTCATAGTACAGTCAAATTGGGGTC
TTCGACCTCAAAAAATACATAATGACATAATTTAGTTTCATGTAATGAAACTTTGTAAACAGAATACATACATGTGTATATGTAAAGAAT
TTCAATCAAATGAAACGTTATCCTATTGGATAGACTAGGCAATTCATCAGCTCACCTGAAATCAGCCAGGAGGAGCAAGGACAAGATGCG
CACAGGGTGGTTTTCCTCATGGATTTTGTCAAATAGATGATCTTTGACACGATTAGACACTCCTCCCCACAAAGGCTTTGAAATCATAAG
GATTTTCCTCATCTCTTTATAGCTTTCCCAAAATCTTTTAAAAAAGAATTTAATTAAATGACAGTCTTTTGGTTACAGACTTAGGATGAG
TAAAAACAAGAAAATTTGGGGAGGGGGAGAAAGAAGAAAGGGATTGCTGTCTCCCTTGAATTCCTCTGTTCCTTAGAGCTTGTGTTACTT
GGACGGAATTGCCAACACCCTTTTTTATAGAGGGTTCTCCACTTGACCTTATTAAGGTTTTATTGGGATATGCTGCAGTGTTTGAAATGA
ACATGCATCATGGCCCCTTCAGGAGCAGAATCATAGCTCTGAAAAGAGAAGCTCCGTTGTGTACTGAGGATATCCATCCATATTCAGCTA
GCTTTCAAATGGGGTAACGATATTTTCTGCATAGATTTTCTTTTAAATTGGTTCTTTGTTTCTGAAGAAAGAATTTTTTTTAACTTCATG
GTTTTATTTATAATAATTTGTTTCTGAAGAAATTTGCCGAGAGTTACAGGTCAAAAAGCCTTGTTACTAGTACAGAATATTTTTATATAT
ATTCCTTCATGATGGTGTAATTTTTTTTAATTGTCCTATGCTTTGTTCGGTTCCTGGGTTAAGTACTTGTTTTTAAGAGCTTGGAAAAAG
TGGGCTTGCTACATCTCTGTTCAAAGAGACATTTGTTCAATCTCTGTGTGTCAACGCCTTGTTGAATTGGTGCTTTGTGGTTGCAATAAA
GCATTGCTTCAGTTT

>7553_7553_1_ATG2B-SAMD13_ATG2B_chr14_96807859_ENST00000359933_SAMD13_chr1_84815314_ENST00000370667_length(amino acids)=381AA_BP=334
MEPESLPRGRSRRNPQPQSAQLPAVTMPWPFSESIKKRACRYLLQRYLGHFLQEKLSLEQLSLDLYQGTGSLAQVPLDKWCLNEILESAD
APLEVTEGFIQSISLSVPWGSLLQDNCALEVRGLEMVFRPRPRPATGSEPMYWSSFMTSSMQLAKECLSQKLTDEQGEGSQPFEGLEKFA
ETIETVLRRVKVTFIDTVLRIEHVPENSKTGTALEIRIERTVYCDETADESSGINVHQPTAFAHKLLQLSGVSLFWDEFSASAKSSPVCS
TAPVETEPKLSPSWNPKIIYEPHPQLTRNLPEIAPSDPVQIGRLIGRLELSLTLKQNEVLPGAKEIDGKSLLLMTRNDVLTGLQLKLGPA
LKIYEYHVKPLQTKHLKNNSS

--------------------------------------------------------------
>7553_7553_2_ATG2B-SAMD13_ATG2B_chr14_96807859_ENST00000359933_SAMD13_chr1_84815314_ENST00000370670_length(transcript)=2118nt_BP=1818nt
GGTGCGGGCGGGGATGCTCGAGAAGGGCTCCAGTCCTCCCAGCGGAGACGGCGGAGCCCCAAGTGTGCGTTTCCGGGGCGCCGAGGTCTG
AGGGGAGCCGGGAGAGCCAGGCCGGCCAGACCGGCCCCCAGACCCCTCTTAACACGGGCGCGGGGCCCCTGCAGCCTGCCGCCCCTCTCG
GCCCAGCCAGCTGCATGGCGTCGCGTCCCCATCCGGAAGGCCTGACGGCCCGCCGGCGCCCCGAGCCCCTAGCCCTTCTCGGGGGCCGCC
CCTCGCCCGCAGCCACCCCGGCTGCCGCTCACCTGCGCGCCCGGCGTCCTCTTCTTCCTTCCTCCGGAGGCGACTGGAGCCGACCGGCGG
TGCCGCCCCCTCCCTCCCCGCCTTCTTCCGCCCCGCCCCCTCGGAGCCGGAACTGCTCCAGCCCCCGCCCTTCTGCCCGCCTTCCGCGGC
CCCAGTGTGGCGTCACTTCCGCCAGCGCCCGGCGGCGCGCCGGGAGTCTGGGTCTCGTGAACGCGCCAGGAGCGTCCCTACAGCCGGGAA
CGCGCCTCGCGGATGACAACAAATTCGTCGCGCGGCGGCAGTGGCGGTGGCTGCCTCAGCCCCTGCCGCCTCCTCTCGCGCTCTCTTGCA
CTCTCTCCGAGCCGGTTGGGACCCTCCTCGGAAGTCCCCTGGCCTGGGGCCAGGAGGACCCCTCTGCGTCTTGCCTCCGCCAGGCCCAGC
GCGAGCGGTGCGGCGCCGGCGATGGGGTCTCCCTGAGGGACTCCCGGCACCAAATAGGGATGGAGGGGCCGCCCCAGGCTTAGGCCCCGC
CGCGGCCTGGAGCCGGAGTCGCTACCCCGAGGCCGGAGCCGTCGCAACCCGCAGCCGCAGTCAGCCCAGCTGCCAGCAGTCACTATGCCT
TGGCCGTTTTCGGAGTCCATCAAGAAGAGGGCCTGCCGGTACCTCCTGCAGAGGTACCTGGGCCACTTTCTGCAGGAGAAGCTGAGCCTG
GAGCAGCTCAGCCTGGACCTGTACCAAGGCACCGGGTCCCTCGCCCAGGTCCCCTTGGACAAATGGTGTCTCAATGAGATCTTGGAGTCA
GCAGATGCACCCTTAGAAGTCACTGAAGGATTCATTCAGTCAATTTCCCTGTCAGTTCCATGGGGCTCTTTACTGCAGGATAATTGTGCA
CTGGAAGTGAGAGGATTAGAAATGGTCTTCCGGCCTAGACCTCGCCCAGCAACTGGTTCTGAGCCTATGTATTGGTCAAGTTTTATGACC
AGCAGTATGCAATTGGCAAAAGAATGTCTTAGCCAGAAACTAACAGATGAACAAGGAGAAGGATCCCAGCCTTTTGAAGGACTTGAAAAG
TTTGCTGAAACCATTGAAACAGTACTAAGAAGAGTAAAAGTCACTTTTATAGATACTGTTTTGAGAATTGAACATGTGCCAGAAAATTCC
AAAACTGGAACTGCACTTGAAATTCGAATAGAAAGAACTGTGTACTGTGATGAAACTGCTGACGAATCCTCAGGAATTAATGTGCATCAA
CCCACTGCTTTTGCTCACAAGTTACTTCAGCTCTCTGGAGTGTCTCTCTTCTGGGATGAGTTTTCTGCATCAGCCAAATCTTCCCCAGTG
TGTTCAACTGCACCAGTGGAAACTGAGCCAAAGCTCTCACCTAGCTGGAACCCCAAAATTATTTATGAGCCACACCCACAGCTAACTAGA
AATTTACCAGAGATAGCACCTTCTGACCCAGTGCAGATTGGACGGTTAATTGGTAGGTTGGAGTTGAGTCTCACGTTGAAACAGAATGAA
GTGCTTCCTGGAGCTAAGGAAATTGATGGAAAATCCCTGCTATTGATGACAAGAAATGATGTGTTGACAGGACTTCAGTTAAAATTGGGG
CCTGCTCTGAAAATCTACGAATATCATGTAAAACCTCTGCAGACAAAGCATTTAAAGAACAACTCTTCATAGTACAGTCAAATTGGGGTC
TTCGACCTCAAAAAATACATAATGACATAATTTAGTTTCATGTAATGAAACTTTGTAAACAGAATACATACATGTGTATATGTAAAGAAT
TTCAATCAAATGAAACGTTATCCTATTGGATAGACTAGGCAATTCATC

>7553_7553_2_ATG2B-SAMD13_ATG2B_chr14_96807859_ENST00000359933_SAMD13_chr1_84815314_ENST00000370670_length(amino acids)=381AA_BP=334
MEPESLPRGRSRRNPQPQSAQLPAVTMPWPFSESIKKRACRYLLQRYLGHFLQEKLSLEQLSLDLYQGTGSLAQVPLDKWCLNEILESAD
APLEVTEGFIQSISLSVPWGSLLQDNCALEVRGLEMVFRPRPRPATGSEPMYWSSFMTSSMQLAKECLSQKLTDEQGEGSQPFEGLEKFA
ETIETVLRRVKVTFIDTVLRIEHVPENSKTGTALEIRIERTVYCDETADESSGINVHQPTAFAHKLLQLSGVSLFWDEFSASAKSSPVCS
TAPVETEPKLSPSWNPKIIYEPHPQLTRNLPEIAPSDPVQIGRLIGRLELSLTLKQNEVLPGAKEIDGKSLLLMTRNDVLTGLQLKLGPA
LKIYEYHVKPLQTKHLKNNSS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATG2B-SAMD13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATG2B-SAMD13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATG2B-SAMD13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATG2BC0023466Leukemia, Monocytic, Chronic1CTD_human
HgeneATG2BC0023470Myeloid Leukemia1CTD_human
HgeneATG2BC0027022Myeloproliferative disease1CTD_human