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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP1R10-FLOT1 (FusionGDB2 ID:HG5514TG10211)

Fusion Gene Summary for PPP1R10-FLOT1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R10-FLOT1
Fusion gene ID: hg5514tg10211
HgeneTgene
Gene symbol

PPP1R10

FLOT1

Gene ID

5514

10211

Gene nameprotein phosphatase 1 regulatory subunit 10flotillin 1
SynonymsCAT53|FB19|PNUTS|PP1R10|R111|p99-
Cytomap('PPP1R10')('FLOT1')

6p21.33

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 1 regulatory subunit 10HLA-C associated transcript 53MHC class I region proline-rich protein CAT53PP1-binding protein of 114 kDaphosphatase 1 nuclear targeting subunitprotein phosphatase 1, regulatory (inhibitor) flotillin-1integral membrane component of caveolae
Modification date2020031320200322
UniProtAcc.

O75955

Ensembl transtripts involved in fusion geneENST00000376511, ENST00000484449, 
ENST00000383586, ENST00000420949, 
ENST00000424446, ENST00000426299, 
ENST00000429597, ENST00000449113, 
ENST00000468706, ENST00000475926, 
ENST00000478528, ENST00000482076, 
ENST00000488513, ENST00000494003, 
ENST00000547333, ENST00000548899, 
ENST00000549281, ENST00000549865, 
ENST00000551493, ENST00000552146, 
Fusion gene scores* DoF score6 X 5 X 4=1207 X 6 X 4=168
# samples 67
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP1R10 [Title/Abstract] AND FLOT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP1R10(30584255)-FLOT1(30698877), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP1R10

GO:0010667

negative regulation of cardiac muscle cell apoptotic process

23426265

TgeneFLOT1

GO:0051580

regulation of neurotransmitter uptake

21399631



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-AA6S-01APPP1R10chr6

30584255

-FLOT1chr6

30698877

-


Top

Fusion Gene ORF analysis for PPP1R10-FLOT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000376511ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-3CDSENST00000376511ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-3CDSENST00000484449ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-3CDSENST00000484449ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000376511ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000376511ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000376511ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000376511ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000376511ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000376511ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000376511ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000376511ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000376511ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000376511ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000376511ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000376511ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000376511ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000376511ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000484449ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000484449ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000484449ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000484449ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000484449ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000484449ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000484449ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000484449ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000484449ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000484449ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000484449ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000484449ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000484449ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
5UTR-intronENST00000484449ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000383586ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000383586ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000420949ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000420949ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000424446ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000424446ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000426299ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000426299ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000429597ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000429597ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000449113ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000449113ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000468706ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000468706ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000475926ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000475926ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000478528ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000478528ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000482076ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000482076ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000488513ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000488513ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000494003ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000494003ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000547333ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000547333ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000548899ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000548899ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000549281ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000549281ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000549865ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000549865ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000551493ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000551493ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000552146ENST00000376389PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-3CDSENST00000552146ENST00000456573PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000383586ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000383586ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000383586ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000383586ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000383586ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000383586ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000383586ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000383586ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000383586ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000383586ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000383586ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000383586ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000383586ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000383586ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000420949ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000420949ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000420949ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000420949ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000420949ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000420949ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000420949ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000420949ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000420949ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000420949ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000420949ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000420949ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000420949ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000420949ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000424446ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000424446ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000424446ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000424446ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000424446ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000424446ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000424446ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000424446ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000424446ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000424446ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000424446ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000424446ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000424446ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000424446ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000426299ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000426299ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000426299ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000426299ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000426299ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000426299ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000426299ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000426299ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000426299ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000426299ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000426299ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000426299ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000426299ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000426299ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000429597ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000429597ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000429597ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000429597ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000429597ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000429597ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000429597ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000429597ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000429597ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000429597ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000429597ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000429597ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000429597ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000429597ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000449113ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000449113ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000449113ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000449113ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000449113ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000449113ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000449113ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000449113ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000449113ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000449113ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000449113ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000449113ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000449113ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000449113ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000468706ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000468706ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000468706ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000468706ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000468706ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000468706ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000468706ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000468706ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000468706ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000468706ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000468706ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000468706ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000468706ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000468706ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000475926ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000475926ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000475926ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000475926ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000475926ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000475926ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000475926ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000475926ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000475926ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000475926ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000475926ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000475926ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000475926ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000475926ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000478528ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000478528ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000478528ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000478528ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000478528ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000478528ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000478528ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000478528ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000478528ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000478528ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000478528ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000478528ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000478528ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000478528ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000482076ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000482076ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000482076ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000482076ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000482076ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000482076ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000482076ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000482076ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000482076ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000482076ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000482076ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000482076ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000482076ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000482076ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000488513ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000488513ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000488513ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000488513ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000488513ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000488513ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000488513ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000488513ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000488513ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000488513ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000488513ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000488513ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000488513ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000488513ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000494003ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000494003ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000494003ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000494003ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000494003ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000494003ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000494003ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000494003ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000494003ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000494003ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000494003ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000494003ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000494003ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000494003ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000547333ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000547333ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000547333ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000547333ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000547333ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000547333ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000547333ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000547333ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000547333ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000547333ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000547333ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000547333ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000547333ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000547333ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000548899ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000548899ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000548899ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000548899ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000548899ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000548899ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000548899ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000548899ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000548899ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000548899ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000548899ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000548899ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000548899ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000548899ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549281ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549281ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549281ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549281ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549281ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549281ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549281ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549281ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549281ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549281ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549281ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549281ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549281ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549281ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549865ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549865ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549865ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549865ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549865ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549865ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549865ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549865ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549865ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549865ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549865ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549865ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549865ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000549865ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000551493ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000551493ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000551493ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000551493ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000551493ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000551493ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000551493ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000551493ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000551493ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000551493ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000551493ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000551493ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000551493ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000551493ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000552146ENST00000383382PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000552146ENST00000383562PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000552146ENST00000420604PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000552146ENST00000430843PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000552146ENST00000436822PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000552146ENST00000444632PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000552146ENST00000460694PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000552146ENST00000466680PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000552146ENST00000470163PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000552146ENST00000470643PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000552146ENST00000490802PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000552146ENST00000492441PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000552146ENST00000496175PPP1R10chr6

30584255

-FLOT1chr6

30698877

-
intron-intronENST00000552146ENST00000553223PPP1R10chr6

30584255

-FLOT1chr6

30698877

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PPP1R10-FLOT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for PPP1R10-FLOT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:30584255/:30698877)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FLOT1

O75955

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PPP1R10-FLOT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PPP1R10-FLOT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP1R10-FLOT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP1R10-FLOT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0034362Q Fever1CTD_human
TgeneC0519066Acute Q fever1CTD_human
TgeneC1443892Chronic Q Fever1CTD_human
TgeneC2973787Coxiella burnetii Infection1CTD_human