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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:ARHGEF10L-GPR137B (FusionGDB2 ID:HG55160TG7107)

Fusion Gene Summary for ARHGEF10L-GPR137B

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF10L-GPR137B
Fusion gene ID: hg55160tg7107
HgeneTgene
Gene symbol

ARHGEF10L

GPR137B

Gene ID

55160

7107

Gene nameRho guanine nucleotide exchange factor 10 likeG protein-coupled receptor 137B
SynonymsGrinchGEFTM7SF1
Cytomap('ARHGEF10L')('GPR137B')

1p36.13

1q42.3

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 10-like proteinRho guanine nucleotide exchange factor (GEF) 10-likeintegral membrane protein GPR137Btransmembrane 7 superfamily member 1 (upregulated in kidney)transmembrane 7 superfamily member 1 protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000469726, ENST00000167825, 
ENST00000361221, ENST00000375408, 
ENST00000375415, ENST00000434513, 
ENST00000452522, ENST00000375420, 
Fusion gene scores* DoF score12 X 12 X 12=17284 X 3 X 2=24
# samples 174
** MAII scorelog2(17/1728*10)=-3.34549656602577
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARHGEF10L [Title/Abstract] AND GPR137B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF10L(17991090)-GPR137B(236368426), # samples:1
Anticipated loss of major functional domain due to fusion event.ARHGEF10L-GPR137B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF10L-GPR137B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGEF10L

GO:0032933

SREBP signaling pathway

16112081

HgeneARHGEF10L

GO:0051496

positive regulation of stress fiber assembly

16112081


check buttonFusion gene breakpoints across ARHGEF10L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GPR137B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A922-01AARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+


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Fusion Gene ORF analysis for ARHGEF10L-GPR137B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000469726ENST00000366592ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
3UTR-3UTRENST00000469726ENST00000477559ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
3UTR-intronENST00000469726ENST00000366591ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
5CDS-3UTRENST00000167825ENST00000477559ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
5CDS-3UTRENST00000361221ENST00000477559ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
5CDS-3UTRENST00000375408ENST00000477559ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
5CDS-3UTRENST00000375415ENST00000477559ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
5CDS-3UTRENST00000434513ENST00000477559ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
5CDS-3UTRENST00000452522ENST00000477559ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
5CDS-intronENST00000167825ENST00000366591ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
5CDS-intronENST00000361221ENST00000366591ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
5CDS-intronENST00000375408ENST00000366591ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
5CDS-intronENST00000375415ENST00000366591ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
5CDS-intronENST00000434513ENST00000366591ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
5CDS-intronENST00000452522ENST00000366591ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
In-frameENST00000167825ENST00000366592ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
In-frameENST00000361221ENST00000366592ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
In-frameENST00000375408ENST00000366592ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
In-frameENST00000375415ENST00000366592ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
In-frameENST00000434513ENST00000366592ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
In-frameENST00000452522ENST00000366592ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
intron-3CDSENST00000375420ENST00000366592ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
intron-3UTRENST00000375420ENST00000477559ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+
intron-intronENST00000375420ENST00000366591ARHGEF10Lchr1

17991090

+GPR137Bchr1

236368426

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000434513ARHGEF10Lchr117991090+ENST00000366592GPR137Bchr1236368426+4135315315633861076
ENST00000361221ARHGEF10Lchr117991090+ENST00000366592GPR137Bchr1236368426+4150316815634011081
ENST00000452522ARHGEF10Lchr117991090+ENST00000366592GPR137Bchr1236368426+4033305115632841042
ENST00000375415ARHGEF10Lchr117991090+ENST00000366592GPR137Bchr1236368426+391729354031681042
ENST00000375408ARHGEF10Lchr117991090+ENST00000366592GPR137Bchr1236368426+33482366382599853
ENST00000167825ARHGEF10Lchr117991090+ENST00000366592GPR137Bchr1236368426+3100211802351783

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000434513ENST00000366592ARHGEF10Lchr117991090+GPR137Bchr1236368426+0.0011564830.99884343
ENST00000361221ENST00000366592ARHGEF10Lchr117991090+GPR137Bchr1236368426+0.0021537870.99784625
ENST00000452522ENST00000366592ARHGEF10Lchr117991090+GPR137Bchr1236368426+0.0014626390.9985374
ENST00000375415ENST00000366592ARHGEF10Lchr117991090+GPR137Bchr1236368426+0.0012723990.9987276
ENST00000375408ENST00000366592ARHGEF10Lchr117991090+GPR137Bchr1236368426+0.0069611150.99303895
ENST00000167825ENST00000366592ARHGEF10Lchr117991090+GPR137Bchr1236368426+0.012223410.98777664

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Fusion Genomic Features for ARHGEF10L-GPR137B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGEF10Lchr117991090+GPR137Bchr1236368425+0.0006291450.9993709
ARHGEF10Lchr117991090+GPR137Bchr1236368425+0.0006291450.9993709

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGEF10L-GPR137B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:17991090/chr1:236368426)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF10Lchr1:17991090chr1:236368426ENST00000167825+1518316_503706983.0DomainDH
HgeneARHGEF10Lchr1:17991090chr1:236368426ENST00000361221+2629316_50310031280.0DomainDH
HgeneARHGEF10Lchr1:17991090chr1:236368426ENST00000375415+2427316_5039641241.0DomainDH
HgeneARHGEF10Lchr1:17991090chr1:236368426ENST00000434513+2527316_5039981068.0DomainDH
HgeneARHGEF10Lchr1:17991090chr1:236368426ENST00000452522+2528316_5039641241.0DomainDH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGPR137Bchr1:17991090chr1:236368426ENST0000036659247101_111322400.0Topological domainLumenal
TgeneGPR137Bchr1:17991090chr1:236368426ENST0000036659247133_159322400.0Topological domainCytoplasmic
TgeneGPR137Bchr1:17991090chr1:236368426ENST0000036659247181_188322400.0Topological domainLumenal
TgeneGPR137Bchr1:17991090chr1:236368426ENST00000366592471_46322400.0Topological domainLumenal
TgeneGPR137Bchr1:17991090chr1:236368426ENST0000036659247210_237322400.0Topological domainCytoplasmic
TgeneGPR137Bchr1:17991090chr1:236368426ENST0000036659247259_292322400.0Topological domainLumenal
TgeneGPR137Bchr1:17991090chr1:236368426ENST0000036659247314_399322400.0Topological domainCytoplasmic
TgeneGPR137Bchr1:17991090chr1:236368426ENST000003665924768_79322400.0Topological domainCytoplasmic
TgeneGPR137Bchr1:17991090chr1:236368426ENST0000036659247112_132322400.0TransmembraneHelical%3B Name%3D3
TgeneGPR137Bchr1:17991090chr1:236368426ENST0000036659247160_180322400.0TransmembraneHelical%3B Name%3D4
TgeneGPR137Bchr1:17991090chr1:236368426ENST0000036659247189_209322400.0TransmembraneHelical%3B Name%3D5
TgeneGPR137Bchr1:17991090chr1:236368426ENST0000036659247238_258322400.0TransmembraneHelical%3B Name%3D6
TgeneGPR137Bchr1:17991090chr1:236368426ENST0000036659247293_313322400.0TransmembraneHelical%3B Name%3D7
TgeneGPR137Bchr1:17991090chr1:236368426ENST000003665924747_67322400.0TransmembraneHelical%3B Name%3D1
TgeneGPR137Bchr1:17991090chr1:236368426ENST000003665924780_100322400.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for ARHGEF10L-GPR137B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6180_6180_1_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000167825_GPR137B_chr1_236368426_ENST00000366592_length(transcript)=3100nt_BP=2118nt
ATGTTACCCAGCAGCTCGTGGGGGAAGAGGAAGCTGCGAGGCAGGCTGGGGTGGGTGCGGAGTGATGCCCGGGGCGTGATGTGGGCCCGG
CAGGAGGGTCTGCACCACCCCCACCCCCACGCCGTCATCCGCTGTCCCTCCTCCTCCTCCTCCTCTGTCTCCTGCTCAGGTGACTCGGAG
GAGGAGGACATGGGGCTCCTGGAGGTCAGCGTTTCGGACATCAAGCCCCCAGCCCCAGAGCTGGGCCCCATGCCAGAGGGCCTGAGCCCT
CAGCAGGTGGTCCGGAGGCATATCCTGGGCTCCATCGTGCAGAGCGAAGGCAGCTACGTGGAGTCTCTGAAGCGGATACTCCAGGACTAC
CGCAACCCCCTGATGGAGATGGAGCCCAAGGCGCTGAGCGCCCGCAAGTGCCAGGTGGTGTTCTTCCGCGTGAAGGAGATCCTGCACTGC
CACTCCATGTTCCAGATCGCCCTGTCCTCCCGCGTGGCTGAGTGGGATTCCACCGAGAAGATCGGGGACCTCTTCGTGGCCTCGGACATG
CTGAAGAACACCCCCAGGGGCCATCCGGACAGGCTGTCGCTGCAGCTGGCCCTCACAGAGCTGGAGACGCTGGCTGAGAAGCTGAACGAG
CAGAAGCGGCTGGCTGACCAGGTGGCTGAGATCCAGCAGCTGACCAAGAGCGTCAGTGACCGCAGCAGCCTCAACAAGCTGTTGACCTCA
GGCCAGCGGCAGCTGCTCCTGTGTGAGACGTTGACGGAGACCGTGTACGGTGACCGCGGGCAGCTAATTAAGTCCAAGGAGCGTCGGGTC
TTCCTGCTCAACGACATGCTTGTCTGTGCCAACATCAACTTCAAGGGCCAGCTGGAGATCAGCAGCCTGGTGCCCCTGGGGCCCAAGTAT
GTGGTGAAGTGGAACACGGCGCTGCCCCAGGTGCAGGTGGTGGAGGTGGGCCAGGACGGTGGCACCTATGACAAGGACAATGTGCTCATC
CAGCACTCAGGCGCCAAGAAGGCCTCTGCCTCAGGGCAGGCTCAGAATAAGGTGTACCTCGGCCCCCCACGCCTCTTCCAGGAGCTGCAG
GACCTGCAGAAGGACCTGGCCGTGGTGGAGCAGATCACGCTTCTCATCAGCACGCTGCACGGCACCTACCAGAACCTGAACATGACTGTG
GCTCAAGACTGGTGCCTGGCCCTGCAGAGGCTGATGCGGGTGAAGGAGGAAGAGATCCACTCGGCCAACAAGTGCCGTCTCAGGCTCCTG
CTTCCTGGGAAACCCGACAAGTCCGGCCGCCCCATTAGCTTCATGGTGGTTTTCATCACCCCCAACCCCCTGAGCAAGATTTCCTGGGTC
AACAGGTTACATTTGGCCAAAATCGGACTCCGGGAGGAGAACCAGCCAGGCTGGCTATGCCCGGATGAGGACAAGAAGAGCAAAGCCCCA
TTCTGGTGCCCGATCCTGGCCTGCTGCATCCCTGCCTTCTCCTCCCGGGCACTCAGCCTGCAGCTTGGGGCCCTGGTCCACAGTCCTGTC
AACTGTCCCCTGCTGGGTTTCTCAGCAGTCAGCACCTCCCTTCCACAGGGCTACCTCTGGGTCGGGGGCGGACAGGAAGGCGCAGGGGGC
CAGGTGGAAATCTTTTCCTTGAACCGGCCCTCGCCCCGCACCGTCAAGTCCTTCCCACTGGCAGCCCCTGTGCTCTGCATGGAGTATATC
CCGGAGCTGGAGGAGGAGGCGGAGAGCAGAGACGAGAGCCCGACAGTTGCTGACCCCTCGGCCACGGTGCATCCAACCATCTGCCTCGGG
CTCCAGGATGGCAGCATCCTCCTCTACAGCAGTGTGGACACTGGCACCCAGTGCCTGGTGAGCTGCAGGAGCCCAGGTCTGCAGCCTGTG
CTCTGCCTGCGACACAGCCCCTTCCACCTGCTCGCTGGCCTGCAGGATGGGACCCTTGCTGCTTACCCTCGGACCAGCGGAGGTGTCCTG
TGGGACCTGGAGAGCCCTCCCGTGTGCCTGACTGTGGGGCCCGGGCCTGTCCGCACCCTGTTGAGCCTGGAGGATGCCGTGTGGGCCAGC
TGTGGGCCCTGGGTCACTGTCCTGGAAGCCACCACCCTGCAGCCTCAGACCAACCCTGGAATGGTCCCCAGCCATGGATTCAGTCCCAGA
TCTTATTTCTTTGACAACCCTCGAAGATATGACAGTGATGATGACCTTGCCTGGAACATTGCCCCTCAGGGACTTCAGGGAGGTTTTGCT
CCAGATTACTATGATTGGGGACAACAAACTAACAGCTTCCTGGCACAAGCAGGAACTTTGCAAGACTCAACTTTGGATCCTGACAAACCA
AGCCTTGGGTAGCATCAGTTAACAGTTTTATGGACGATTCCTCAGATGAAAAGCTTCAGAAAAGCATAGTGACAGCTGAATTTTTAGGGC
ACTTTTCCTTAAGAAATAGAACTTGATTTTTATTTGTTACAGGTTTCCAATGGCCCCATAGGAATAAGCAATAATGTAGACTGATAAACC
CTTATTTTAGTACTAAAGAGGGAGCCTTGCTATTTCAGTGGGTATAATTTAAACTTTTTAAAGAAAATCTGTACTTTTATAAAGATGTAT
TTTGTATAACTTAAATAATAATGCTAAAGTATACTAGGGTTTTTTTTTCTTGAGAATGTTACTGCAATCATGTTGTAGTTTGCACAGACT
TTTATGCATAATTCACTTTAAAAATATAGAATATATGGTCTAATAGTTTTTTAAAGCTTTTGGACTAAAGTATTCCACAAATCTTACCTC
TTTAGGTCACTGATGGTCACTCCGATTCTGAGTGCCACATTGGTAGACTCCTAAAATACAGTTGACAACTTAGCCAATTGCAACTCCAGT
GTTGATAATTAAAATGAAATGGTAAAGCAGCAGACTGTAAGGTCTTTAGAGATTTTTTTTTTAAGGTTCAGGCCGTAGGTTCCTCAAGGA
ATCTCTTAAGTTTTGCCCAAAGACTGGTACTTCCTTTCAGTAGGGCGCTAATGTATACACATTAATGATAAGTTGATAACATTAAAAATG

>6180_6180_1_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000167825_GPR137B_chr1_236368426_ENST00000366592_length(amino acids)=783AA_BP=706
MLPSSSWGKRKLRGRLGWVRSDARGVMWARQEGLHHPHPHAVIRCPSSSSSSVSCSGDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSP
QQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASDM
LKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRV
FLLNDMLVCANINFKGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQ
DLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWV
NRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGG
QVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPV
LCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPWVTVLEATTLQPQTNPGMVPSHGFSPR

--------------------------------------------------------------
>6180_6180_2_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000361221_GPR137B_chr1_236368426_ENST00000366592_length(transcript)=4150nt_BP=3168nt
GCGCCGTCCCGGCCATGGGCGCCCGCGGCGGCCTGCGGAGCTGGAGGCGCGGCGCCGGCCGCCAGGCGCCTTTGTGAGCGGCGCGGACGA
CAAAGGCGCGGGCCCGGGCAGCCGAGGTGTGTAGCTGGGACGGTGCTGGTCTGAGCTGGACCTTGTCTGATGGCTTCCTCCAACCCTCCT
CCACAGCCTGCCATAGGAGATCAGCTGGTTCCAGGAGTCCCAGGCCCCTCCTCTGAGGCAGAGGACGACCCAGGAGAGGCGTTTGAGTTT
GATGACAGTGATGATGAAGAGGACACCAGCGCAGCCCTGGGCGTCCCCAGCCTTGCTCCTGAGAGGGACACAGACCCCCCACTGATCCAC
TTGGACTCCATCCCTGTCACTGACCCAGACCCAGCAGCTGCTCCACCCGGCACAGGGGTGCCAGCCTGGGTGAGCAATGGGGATGCAGCG
GACGCAGCCTTCTCCGGGGCCCGGCACTCCAGCTGGAAGCGGAAGAGTTCCCGTCGCATTGACCGGTTCACTTTCCCCGCCCTGGAAGAG
GATGTGATTTATGACGACGTCCCCTGCGAGAGCCCAGATGCGCATCAGCCCGGGGCAGAGAGGAACCTGCTCTACGAGGATGCGCACCGG
GCTGGGGCCCCTCGGCAGGCGGAGGACCTAGGCTGGAGCTCCAGTGAGTTCGAGAGCTACAGCGAGGACTCGGGGGAGGAGGCCAAGCCG
GAGGTCGAGGTCGAGCCCGCCAAGCACCGAGTGTCCTTCCAGCCCAAGCTTTCTCCAGACCTGACTAGGCTAAAGGAGAGATACGCCAGG
ACTAAGAGAGACATCTTGGCTTTGAGAGTTGGGGGGAGAGACATGCAGGAGCTGAAGCACAAGTACGATTGTAAGATGACCCAGCTCATG
AAGGCCGCCAAGAGCGGGACCAAGGATGGGCTGGAGAAGACACGGATGGCCGTGATGCGCAAAGTCTCCTTCCTGCACAGGAAGGACGTC
CTCGGTGACTCGGAGGAGGAGGACATGGGGCTCCTGGAGGTCAGCGTTTCGGACATCAAGCCCCCAGCCCCAGAGCTGGGCCCCATGCCA
GAGGGCCTGAGCCCTCAGCAGGTGGTCCGGAGGCATATCCTGGGCTCCATCGTGCAGAGCGAAGGCAGCTACGTGGAGTCTCTGAAGCGG
ATACTCCAGGACTACCGCAACCCCCTGATGGAGATGGAGCCCAAGGCGCTGAGCGCCCGCAAGTGCCAGGTGGTGTTCTTCCGCGTGAAG
GAGATCCTGCACTGCCACTCCATGTTCCAGATCGCCCTGTCCTCCCGCGTGGCTGAGTGGGATTCCACCGAGAAGATCGGGGACCTCTTC
GTGGCCTCGTTTTCCAAGTCCATGGTGCTAGATGTGTACAGTGACTACGTGAACAACTTCACCAGTGCCATGTCCATCATCAAGAAGGCC
TGCCTCACCAAGCCTGCCTTCCTCGAGTTCCTCAAGCGACGGCAGGTGTGCAGCCCAGACCGTGTCACCCTCTACGGGCTGATGGTCAAG
CCCATCCAGAGGTTCCCACAGTTCATACTCCTGCTTCAGGACATGCTGAAGAACACCCCCAGGGGCCATCCGGACAGGCTGTCGCTGCAG
CTGGCCCTCACAGAGCTGGAGACGCTGGCTGAGAAGCTGAACGAGCAGAAGCGGCTGGCTGACCAGGTGGCTGAGATCCAGCAGCTGACC
AAGAGCGTCAGTGACCGCAGCAGCCTCAACAAGCTGTTGACCTCAGGCCAGCGGCAGCTGCTCCTGTGTGAGACGTTGACGGAGACCGTG
TACGGTGACCGCGGGCAGCTAATTAAGTCCAAGGAGCGTCGGGTCTTCCTGCTCAACGACATGCTTGTCTGTGCCAACATCAACTTCAAG
CCTGCCAACCACAGGGGCCAGCTGGAGATCAGCAGCCTGGTGCCCCTGGGGCCCAAGTATGTGGTGAAGTGGAACACGGCGCTGCCCCAG
GTGCAGGTGGTGGAGGTGGGCCAGGACGGTGGCACCTATGACAAGGACAATGTGCTCATCCAGCACTCAGGCGCCAAGAAGGCCTCTGCC
TCAGGGCAGGCTCAGAATAAGGTGTACCTCGGCCCCCCACGCCTCTTCCAGGAGCTGCAGGACCTGCAGAAGGACCTGGCCGTGGTGGAG
CAGATCACGCTTCTCATCAGCACGCTGCACGGCACCTACCAGAACCTGAACATGACTGTGGCTCAAGACTGGTGCCTGGCCCTGCAGAGG
CTGATGCGGGTGAAGGAGGAAGAGATCCACTCGGCCAACAAGTGCCGTCTCAGGCTCCTGCTTCCTGGGAAACCCGACAAGTCCGGCCGC
CCCATTAGCTTCATGGTGGTTTTCATCACCCCCAACCCCCTGAGCAAGATTTCCTGGGTCAACAGGTTACATTTGGCCAAAATCGGACTC
CGGGAGGAGAACCAGCCAGGCTGGCTATGCCCGGATGAGGACAAGAAGAGCAAAGCCCCATTCTGGTGCCCGATCCTGGCCTGCTGCATC
CCTGCCTTCTCCTCCCGGGCACTCAGCCTGCAGCTTGGGGCCCTGGTCCACAGTCCTGTCAACTGTCCCCTGCTGGGTTTCTCAGCAGTC
AGCACCTCCCTTCCACAGGGCTACCTCTGGGTCGGGGGCGGACAGGAAGGCGCAGGGGGCCAGGTGGAAATCTTTTCCTTGAACCGGCCC
TCGCCCCGCACCGTCAAGTCCTTCCCACTGGCAGCCCCTGTGCTCTGCATGGAGTATATCCCGGAGCTGGAGGAGGAGGCGGAGAGCAGA
GACGAGAGCCCGACAGTTGCTGACCCCTCGGCCACGGTGCATCCAACCATCTGCCTCGGGCTCCAGGATGGCAGCATCCTCCTCTACAGC
AGTGTGGACACTGGCACCCAGTGCCTGGTGAGCTGCAGGAGCCCAGGTCTGCAGCCTGTGCTCTGCCTGCGACACAGCCCCTTCCACCTG
CTCGCTGGCCTGCAGGATGGGACCCTTGCTGCTTACCCTCGGACCAGCGGAGGTGTCCTGTGGGACCTGGAGAGCCCTCCCGTGTGCCTG
ACTGTGGGGCCCGGGCCTGTCCGCACCCTGTTGAGCCTGGAGGATGCCGTGTGGGCCAGCTGTGGGCCCTGGGTCACTGTCCTGGAAGCC
ACCACCCTGCAGCCTCAGACCAACCCTGGAATGGTCCCCAGCCATGGATTCAGTCCCAGATCTTATTTCTTTGACAACCCTCGAAGATAT
GACAGTGATGATGACCTTGCCTGGAACATTGCCCCTCAGGGACTTCAGGGAGGTTTTGCTCCAGATTACTATGATTGGGGACAACAAACT
AACAGCTTCCTGGCACAAGCAGGAACTTTGCAAGACTCAACTTTGGATCCTGACAAACCAAGCCTTGGGTAGCATCAGTTAACAGTTTTA
TGGACGATTCCTCAGATGAAAAGCTTCAGAAAAGCATAGTGACAGCTGAATTTTTAGGGCACTTTTCCTTAAGAAATAGAACTTGATTTT
TATTTGTTACAGGTTTCCAATGGCCCCATAGGAATAAGCAATAATGTAGACTGATAAACCCTTATTTTAGTACTAAAGAGGGAGCCTTGC
TATTTCAGTGGGTATAATTTAAACTTTTTAAAGAAAATCTGTACTTTTATAAAGATGTATTTTGTATAACTTAAATAATAATGCTAAAGT
ATACTAGGGTTTTTTTTTCTTGAGAATGTTACTGCAATCATGTTGTAGTTTGCACAGACTTTTATGCATAATTCACTTTAAAAATATAGA
ATATATGGTCTAATAGTTTTTTAAAGCTTTTGGACTAAAGTATTCCACAAATCTTACCTCTTTAGGTCACTGATGGTCACTCCGATTCTG
AGTGCCACATTGGTAGACTCCTAAAATACAGTTGACAACTTAGCCAATTGCAACTCCAGTGTTGATAATTAAAATGAAATGGTAAAGCAG
CAGACTGTAAGGTCTTTAGAGATTTTTTTTTTAAGGTTCAGGCCGTAGGTTCCTCAAGGAATCTCTTAAGTTTTGCCCAAAGACTGGTAC
TTCCTTTCAGTAGGGCGCTAATGTATACACATTAATGATAAGTTGATAACATTAAAAATGTAGCTGACTTATCCTATTAAACCTCCTCTG

>6180_6180_2_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000361221_GPR137B_chr1_236368426_ENST00000366592_length(amino acids)=1081AA_BP=1004
MMASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERDTDPPLIHLDSIPVTDPDPAAAPPGTGVPA
WVSNGDAADAAFSGARHSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSE
DSGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYDCKMTQLMKAAKSGTKDGLEKTRMAVMRKV
SFLHRKDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKC
QVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRV
TLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLL
CETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQH
SGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLP
GKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNC
PLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQ
DGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCG
PWVTVLEATTLQPQTNPGMVPSHGFSPRSYFFDNPRRYDSDDDLAWNIAPQGLQGGFAPDYYDWGQQTNSFLAQAGTLQDSTLDPDKPSL

--------------------------------------------------------------
>6180_6180_3_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000375408_GPR137B_chr1_236368426_ENST00000366592_length(transcript)=3348nt_BP=2366nt
ATTAATAGCCGTGGCAGGGCTCGAATCACAGGCCAAGAATGTTACCCAGCAGCTCGTGGGGGAAGAGGAAGCTGCGAGGCAGGCTGGGGT
GGGTGCGGAGTGATGCCCGGGGCGTGATGTGGGCCCGGCAGGAGGGTCTGCACCACCCCCACCCCCACGCCGTCATCCGCTGTCCCTCCT
CCTCCTCCTCCTCTGTCTCCTGCTCAGGTGACTCGGAGGAGGAGGACATGGGGCTCCTGGAGGTCAGCGTTTCGGACATCAAGCCCCCAG
CCCCAGAGCTGGGCCCCATGCCAGAGGGCCTGAGCCCTCAGCAGGTGGTCCGGAGGCATATCCTGGGCTCCATCGTGCAGAGCGAAGGCA
GCTACGTGGAGTCTCTGAAGCGGATACTCCAGGACTACCGCAACCCCCTGATGGAGATGGAGCCCAAGGCGCTGAGCGCCCGCAAGTGCC
AGGTGGTGTTCTTCCGCGTGAAGGAGATCCTGCACTGCCACTCCATGTTCCAGATCGCCCTGTCCTCCCGCGTGGCTGAGTGGGATTCCA
CCGAGAAGATCGGGGACCTCTTCGTGGCCTCGTTTTCCAAGTCCATGGTGCTAGATGTGTACAGTGACTACGTGAACAACTTCACCAGTG
CCATGTCCATCATCAAGAAGGCCTGCCTCACCAAGCCTGCCTTCCTCGAGTTCCTCAAGCGACGGCAGGTGTGCAGCCCAGACCGTGTCA
CCCTCTACGGGCTGATGGTCAAGCCCATCCAGAGGTTCCCACAGTTCATACTCCTGCTTCAGGACATGCTGAAGAACACCCCCAGGGGCC
ATCCGGACAGGCTGTCGCTGCAGCTGGCCCTCACAGAGCTGGAGACGCTGGCTGAGAAGCTGAACGAGCAGAAGCGGCTGGCTGACCAGG
TGGCTGAGATCCAGCAGCTGACCAAGAGCGTCAGTGACCGCAGCAGCCTCAACAAGCTGTTGACCTCAGGCCAGCGGCAGCTGCTCCTGT
GTGAGACGTTGACGGAGACCGTGTACGGTGACCGCGGGCAGCTAATTAAGTCCAAGGAGCGTCGGGTCTTCCTGCTCAACGACATGCTTG
TCTGTGCCAACATCAACTTCAAGGGCCAGCTGGAGATCAGCAGCCTGGTGCCCCTGGGGCCCAAGTATGTGGTGAAGTGGAACACGGCGC
TGCCCCAGGTGCAGGTGGTGGAGGTGGGCCAGGACGGTGGCACCTATGACAAGGACAATGTGCTCATCCAGCACTCAGGCGCCAAGAAGG
CCTCTGCCTCAGGGCAGGCTCAGAATAAGGTGTACCTCGGCCCCCCACGCCTCTTCCAGGAGCTGCAGGACCTGCAGAAGGACCTGGCCG
TGGTGGAGCAGATCACGCTTCTCATCAGCACGCTGCACGGCACCTACCAGAACCTGAACATGACTGTGGCTCAAGACTGGTGCCTGGCCC
TGCAGAGGCTGATGCGGGTGAAGGAGGAAGAGATCCACTCGGCCAACAAGTGCCGTCTCAGGCTCCTGCTTCCTGGGAAACCCGACAAGT
CCGGCCGCCCCATTAGCTTCATGGTGGTTTTCATCACCCCCAACCCCCTGAGCAAGATTTCCTGGGTCAACAGGTTACATTTGGCCAAAA
TCGGACTCCGGGAGGAGAACCAGCCAGGCTGGCTATGCCCGGATGAGGACAAGAAGAGCAAAGCCCCATTCTGGTGCCCGATCCTGGCCT
GCTGCATCCCTGCCTTCTCCTCCCGGGCACTCAGCCTGCAGCTTGGGGCCCTGGTCCACAGTCCTGTCAACTGTCCCCTGCTGGGTTTCT
CAGCAGTCAGCACCTCCCTTCCACAGGGCTACCTCTGGGTCGGGGGCGGACAGGAAGGCGCAGGGGGCCAGGTGGAAATCTTTTCCTTGA
ACCGGCCCTCGCCCCGCACCGTCAAGTCCTTCCCACTGGCAGCCCCTGTGCTCTGCATGGAGTATATCCCGGAGCTGGAGGAGGAGGCGG
AGAGCAGAGACGAGAGCCCGACAGTTGCTGACCCCTCGGCCACGGTGCATCCAACCATCTGCCTCGGGCTCCAGGATGGCAGCATCCTCC
TCTACAGCAGTGTGGACACTGGCACCCAGTGCCTGGTGAGCTGCAGGAGCCCAGGTCTGCAGCCTGTGCTCTGCCTGCGACACAGCCCCT
TCCACCTGCTCGCTGGCCTGCAGGATGGGACCCTTGCTGCTTACCCTCGGACCAGCGGAGGTGTCCTGTGGGACCTGGAGAGCCCTCCCG
TGTGCCTGACTGTGGGGCCCGGGCCTGTCCGCACCCTGTTGAGCCTGGAGGATGCCGTGTGGGCCAGCTGTGGGCCCTGGGTCACTGTCC
TGGAAGCCACCACCCTGCAGCCTCAGACCAACCCTGGAATGGTCCCCAGCCATGGATTCAGTCCCAGATCTTATTTCTTTGACAACCCTC
GAAGATATGACAGTGATGATGACCTTGCCTGGAACATTGCCCCTCAGGGACTTCAGGGAGGTTTTGCTCCAGATTACTATGATTGGGGAC
AACAAACTAACAGCTTCCTGGCACAAGCAGGAACTTTGCAAGACTCAACTTTGGATCCTGACAAACCAAGCCTTGGGTAGCATCAGTTAA
CAGTTTTATGGACGATTCCTCAGATGAAAAGCTTCAGAAAAGCATAGTGACAGCTGAATTTTTAGGGCACTTTTCCTTAAGAAATAGAAC
TTGATTTTTATTTGTTACAGGTTTCCAATGGCCCCATAGGAATAAGCAATAATGTAGACTGATAAACCCTTATTTTAGTACTAAAGAGGG
AGCCTTGCTATTTCAGTGGGTATAATTTAAACTTTTTAAAGAAAATCTGTACTTTTATAAAGATGTATTTTGTATAACTTAAATAATAAT
GCTAAAGTATACTAGGGTTTTTTTTTCTTGAGAATGTTACTGCAATCATGTTGTAGTTTGCACAGACTTTTATGCATAATTCACTTTAAA
AATATAGAATATATGGTCTAATAGTTTTTTAAAGCTTTTGGACTAAAGTATTCCACAAATCTTACCTCTTTAGGTCACTGATGGTCACTC
CGATTCTGAGTGCCACATTGGTAGACTCCTAAAATACAGTTGACAACTTAGCCAATTGCAACTCCAGTGTTGATAATTAAAATGAAATGG
TAAAGCAGCAGACTGTAAGGTCTTTAGAGATTTTTTTTTTAAGGTTCAGGCCGTAGGTTCCTCAAGGAATCTCTTAAGTTTTGCCCAAAG
ACTGGTACTTCCTTTCAGTAGGGCGCTAATGTATACACATTAATGATAAGTTGATAACATTAAAAATGTAGCTGACTTATCCTATTAAAC

>6180_6180_3_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000375408_GPR137B_chr1_236368426_ENST00000366592_length(amino acids)=853AA_BP=776
MLPSSSWGKRKLRGRLGWVRSDARGVMWARQEGLHHPHPHAVIRCPSSSSSSVSCSGDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSP
QQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFS
KSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTE
LETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKGQLEI
SSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLH
GTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLC
PDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPL
AAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLA
AYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPWVTVLEATTLQPQTNPGMVPSHGFSPRSYFFDNPRRYDSDDDLAWNI

--------------------------------------------------------------
>6180_6180_4_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000375415_GPR137B_chr1_236368426_ENST00000366592_length(transcript)=3917nt_BP=2935nt
GTGTGTAGCTGGGACGGTGCTGGTCTGAGCTGGACCTTGTCTGATGGCTTCCTCCAACCCTCCTCCACAGCCTGCCATAGGAGATCAGCT
GGTTCCAGGAGTCCCAGGCCCCTCCTCTGAGGCAGAGGACGACCCAGGAGAGGCGTTTGAGTTTGATGACAGTGATGATGAAGAGGACAC
CAGCGCAGCCCTGGGCGTCCCCAGCCTTGCTCCTGAGAGGGACACAGACCCCCCACTGATCCACTTGGACTCCATCCCTGTCACTGACCC
AGACCCAGCAGCTGCTCCACCCGGCACAGGGGTGCCAGCCTGGGTGAGCAATGGGGATGCAGCGGACGCAGCCTTCTCCGGGGCCCGGCA
CTCCAGCTGGAAGCGGAAGAGTTCCCGTCGCATTGACCGGTTCACTTTCCCCGCCCTGGAAGAGGATGTGATTTATGACGACGTCCCCTG
CGAGAGCCCAGATGCGCATCAGCCCGGGGCAGAGAGGAACCTGCTCTACGAGGATGCGCACCGGGCTGGGGCCCCTCGGCAGGCGGAGGA
CCTAGGCTGGAGCTCCAGTGAGTTCGAGAGCTACAGCGAGGACTCGGGGGAGGAGGCCAAGCCGGAGGTCGAGGTCGAGCCCGCCAAGCA
CCGAGTGTCCTTCCAGCCCAAGATGACCCAGCTCATGAAGGCCGCCAAGAGCGGGACCAAGGATGGGCTGGAGAAGACACGGATGGCCGT
GATGCGCAAAGTCTCCTTCCTGCACAGGAAGGACGTCCTCGGTGACTCGGAGGAGGAGGACATGGGGCTCCTGGAGGTCAGCGTTTCGGA
CATCAAGCCCCCAGCCCCAGAGCTGGGCCCCATGCCAGAGGGCCTGAGCCCTCAGCAGGTGGTCCGGAGGCATATCCTGGGCTCCATCGT
GCAGAGCGAAGGCAGCTACGTGGAGTCTCTGAAGCGGATACTCCAGGACTACCGCAACCCCCTGATGGAGATGGAGCCCAAGGCGCTGAG
CGCCCGCAAGTGCCAGGTGGTGTTCTTCCGCGTGAAGGAGATCCTGCACTGCCACTCCATGTTCCAGATCGCCCTGTCCTCCCGCGTGGC
TGAGTGGGATTCCACCGAGAAGATCGGGGACCTCTTCGTGGCCTCGTTTTCCAAGTCCATGGTGCTAGATGTGTACAGTGACTACGTGAA
CAACTTCACCAGTGCCATGTCCATCATCAAGAAGGCCTGCCTCACCAAGCCTGCCTTCCTCGAGTTCCTCAAGCGACGGCAGGTGTGCAG
CCCAGACCGTGTCACCCTCTACGGGCTGATGGTCAAGCCCATCCAGAGGTTCCCACAGTTCATACTCCTGCTTCAGGACATGCTGAAGAA
CACCCCCAGGGGCCATCCGGACAGGCTGTCGCTGCAGCTGGCCCTCACAGAGCTGGAGACGCTGGCTGAGAAGCTGAACGAGCAGAAGCG
GCTGGCTGACCAGGTGGCTGAGATCCAGCAGCTGACCAAGAGCGTCAGTGACCGCAGCAGCCTCAACAAGCTGTTGACCTCAGGCCAGCG
GCAGCTGCTCCTGTGTGAGACGTTGACGGAGACCGTGTACGGTGACCGCGGGCAGCTAATTAAGTCCAAGGAGCGTCGGGTCTTCCTGCT
CAACGACATGCTTGTCTGTGCCAACATCAACTTCAAGCCTGCCAACCACAGGGGCCAGCTGGAGATCAGCAGCCTGGTGCCCCTGGGGCC
CAAGTATGTGGTGAAGTGGAACACGGCGCTGCCCCAGGTGCAGGTGGTGGAGGTGGGCCAGGACGGTGGCACCTATGACAAGGACAATGT
GCTCATCCAGCACTCAGGCGCCAAGAAGGCCTCTGCCTCAGGGCAGGCTCAGAATAAGGTGTACCTCGGCCCCCCACGCCTCTTCCAGGA
GCTGCAGGACCTGCAGAAGGACCTGGCCGTGGTGGAGCAGATCACGCTTCTCATCAGCACGCTGCACGGCACCTACCAGAACCTGAACAT
GACTGTGGCTCAAGACTGGTGCCTGGCCCTGCAGAGGCTGATGCGGGTGAAGGAGGAAGAGATCCACTCGGCCAACAAGTGCCGTCTCAG
GCTCCTGCTTCCTGGGAAACCCGACAAGTCCGGCCGCCCCATTAGCTTCATGGTGGTTTTCATCACCCCCAACCCCCTGAGCAAGATTTC
CTGGGTCAACAGGTTACATTTGGCCAAAATCGGACTCCGGGAGGAGAACCAGCCAGGCTGGCTATGCCCGGATGAGGACAAGAAGAGCAA
AGCCCCATTCTGGTGCCCGATCCTGGCCTGCTGCATCCCTGCCTTCTCCTCCCGGGCACTCAGCCTGCAGCTTGGGGCCCTGGTCCACAG
TCCTGTCAACTGTCCCCTGCTGGGTTTCTCAGCAGTCAGCACCTCCCTTCCACAGGGCTACCTCTGGGTCGGGGGCGGACAGGAAGGCGC
AGGGGGCCAGGTGGAAATCTTTTCCTTGAACCGGCCCTCGCCCCGCACCGTCAAGTCCTTCCCACTGGCAGCCCCTGTGCTCTGCATGGA
GTATATCCCGGAGCTGGAGGAGGAGGCGGAGAGCAGAGACGAGAGCCCGACAGTTGCTGACCCCTCGGCCACGGTGCATCCAACCATCTG
CCTCGGGCTCCAGGATGGCAGCATCCTCCTCTACAGCAGTGTGGACACTGGCACCCAGTGCCTGGTGAGCTGCAGGAGCCCAGGTCTGCA
GCCTGTGCTCTGCCTGCGACACAGCCCCTTCCACCTGCTCGCTGGCCTGCAGGATGGGACCCTTGCTGCTTACCCTCGGACCAGCGGAGG
TGTCCTGTGGGACCTGGAGAGCCCTCCCGTGTGCCTGACTGTGGGGCCCGGGCCTGTCCGCACCCTGTTGAGCCTGGAGGATGCCGTGTG
GGCCAGCTGTGGGCCCTGGGTCACTGTCCTGGAAGCCACCACCCTGCAGCCTCAGACCAACCCTGGAATGGTCCCCAGCCATGGATTCAG
TCCCAGATCTTATTTCTTTGACAACCCTCGAAGATATGACAGTGATGATGACCTTGCCTGGAACATTGCCCCTCAGGGACTTCAGGGAGG
TTTTGCTCCAGATTACTATGATTGGGGACAACAAACTAACAGCTTCCTGGCACAAGCAGGAACTTTGCAAGACTCAACTTTGGATCCTGA
CAAACCAAGCCTTGGGTAGCATCAGTTAACAGTTTTATGGACGATTCCTCAGATGAAAAGCTTCAGAAAAGCATAGTGACAGCTGAATTT
TTAGGGCACTTTTCCTTAAGAAATAGAACTTGATTTTTATTTGTTACAGGTTTCCAATGGCCCCATAGGAATAAGCAATAATGTAGACTG
ATAAACCCTTATTTTAGTACTAAAGAGGGAGCCTTGCTATTTCAGTGGGTATAATTTAAACTTTTTAAAGAAAATCTGTACTTTTATAAA
GATGTATTTTGTATAACTTAAATAATAATGCTAAAGTATACTAGGGTTTTTTTTTCTTGAGAATGTTACTGCAATCATGTTGTAGTTTGC
ACAGACTTTTATGCATAATTCACTTTAAAAATATAGAATATATGGTCTAATAGTTTTTTAAAGCTTTTGGACTAAAGTATTCCACAAATC
TTACCTCTTTAGGTCACTGATGGTCACTCCGATTCTGAGTGCCACATTGGTAGACTCCTAAAATACAGTTGACAACTTAGCCAATTGCAA
CTCCAGTGTTGATAATTAAAATGAAATGGTAAAGCAGCAGACTGTAAGGTCTTTAGAGATTTTTTTTTTAAGGTTCAGGCCGTAGGTTCC
TCAAGGAATCTCTTAAGTTTTGCCCAAAGACTGGTACTTCCTTTCAGTAGGGCGCTAATGTATACACATTAATGATAAGTTGATAACATT

>6180_6180_4_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000375415_GPR137B_chr1_236368426_ENST00000366592_length(amino acids)=1042AA_BP=965
MMASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERDTDPPLIHLDSIPVTDPDPAAAPPGTGVPA
WVSNGDAADAAFSGARHSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSE
DSGEEAKPEVEVEPAKHRVSFQPKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPE
GLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFV
ASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQL
ALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKP
ANHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQ
ITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLR
EENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPS
PRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLL
AGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPWVTVLEATTLQPQTNPGMVPSHGFSPRSYFFDNPRRYD

--------------------------------------------------------------
>6180_6180_5_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000434513_GPR137B_chr1_236368426_ENST00000366592_length(transcript)=4135nt_BP=3153nt
GCGCCGTCCCGGCCATGGGCGCCCGCGGCGGCCTGCGGAGCTGGAGGCGCGGCGCCGGCCGCCAGGCGCCTTTGTGAGCGGCGCGGACGA
CAAAGGCGCGGGCCCGGGCAGCCGAGGTGTGTAGCTGGGACGGTGCTGGTCTGAGCTGGACCTTGTCTGATGGCTTCCTCCAACCCTCCT
CCACAGCCTGCCATAGGAGATCAGCTGGTTCCAGGAGTCCCAGGCCCCTCCTCTGAGGCAGAGGACGACCCAGGAGAGGCGTTTGAGTTT
GATGACAGTGATGATGAAGAGGACACCAGCGCAGCCCTGGGCGTCCCCAGCCTTGCTCCTGAGAGGGACACAGACCCCCCACTGATCCAC
TTGGACTCCATCCCTGTCACTGACCCAGACCCAGCAGCTGCTCCACCCGGCACAGGGGTGCCAGCCTGGGTGAGCAATGGGGATGCAGCG
GACGCAGCCTTCTCCGGGGCCCGGCACTCCAGCTGGAAGCGGAAGAGTTCCCGTCGCATTGACCGGTTCACTTTCCCCGCCCTGGAAGAG
GATGTGATTTATGACGACGTCCCCTGCGAGAGCCCAGATGCGCATCAGCCCGGGGCAGAGAGGAACCTGCTCTACGAGGATGCGCACCGG
GCTGGGGCCCCTCGGCAGGCGGAGGACCTAGGCTGGAGCTCCAGTGAGTTCGAGAGCTACAGCGAGGACTCGGGGGAGGAGGCCAAGCCG
GAGGTCGAGGTCGAGCCCGCCAAGCACCGAGTGTCCTTCCAGCCCAAGCTTTCTCCAGACCTGACTAGGCTAAAGGAGAGATACGCCAGG
ACTAAGAGAGACATCTTGGCTTTGAGAGTTGGGGGGAGAGACATGCAGGAGCTGAAGCACAAGTACGATTGTAAGATGACCCAGCTCATG
AAGGCCGCCAAGAGCGGGACCAAGGATGGGCTGGAGAAGACACGGATGGCCGTGATGCGCAAAGTCTCCTTCCTGCACAGGAAGGACGTC
CTCGGTGACTCGGAGGAGGAGGACATGGGGCTCCTGGAGGTCAGCGTTTCGGACATCAAGCCCCCAGCCCCAGAGCTGGGCCCCATGCCA
GAGGGCCTGAGCCCTCAGCAGGTGGTCCGGAGGCATATCCTGGGCTCCATCGTGCAGAGCGAAGGCAGCTACGTGGAGTCTCTGAAGCGG
ATACTCCAGGACTACCGCAACCCCCTGATGGAGATGGAGCCCAAGGCGCTGAGCGCCCGCAAGTGCCAGGTGGTGTTCTTCCGCGTGAAG
GAGATCCTGCACTGCCACTCCATGTTCCAGATCGCCCTGTCCTCCCGCGTGGCTGAGTGGGATTCCACCGAGAAGATCGGGGACCTCTTC
GTGGCCTCGTTTTCCAAGTCCATGGTGCTAGATGTGTACAGTGACTACGTGAACAACTTCACCAGTGCCATGTCCATCATCAAGAAGGCC
TGCCTCACCAAGCCTGCCTTCCTCGAGTTCCTCAAGCGACGGCAGGTGTGCAGCCCAGACCGTGTCACCCTCTACGGGCTGATGGTCAAG
CCCATCCAGAGGTTCCCACAGTTCATACTCCTGCTTCAGGACATGCTGAAGAACACCCCCAGGGGCCATCCGGACAGGCTGTCGCTGCAG
CTGGCCCTCACAGAGCTGGAGACGCTGGCTGAGAAGCTGAACGAGCAGAAGCGGCTGGCTGACCAGGTGGCTGAGATCCAGCAGCTGACC
AAGAGCGTCAGTGACCGCAGCAGCCTCAACAAGCTGTTGACCTCAGGCCAGCGGCAGCTGCTCCTGTGTGAGACGTTGACGGAGACCGTG
TACGGTGACCGCGGGCAGCTAATTAAGTCCAAGGAGCGTCGGGTCTTCCTGCTCAACGACATGCTTGTCTGTGCCAACATCAACTTCAAG
GGCCAGCTGGAGATCAGCAGCCTGGTGCCCCTGGGGCCCAAGTATGTGGTGAAGTGGAACACGGCGCTGCCCCAGGTGCAGGTGGTGGAG
GTGGGCCAGGACGGTGGCACCTATGACAAGGACAATGTGCTCATCCAGCACTCAGGCGCCAAGAAGGCCTCTGCCTCAGGGCAGGCTCAG
AATAAGGTGTACCTCGGCCCCCCACGCCTCTTCCAGGAGCTGCAGGACCTGCAGAAGGACCTGGCCGTGGTGGAGCAGATCACGCTTCTC
ATCAGCACGCTGCACGGCACCTACCAGAACCTGAACATGACTGTGGCTCAAGACTGGTGCCTGGCCCTGCAGAGGCTGATGCGGGTGAAG
GAGGAAGAGATCCACTCGGCCAACAAGTGCCGTCTCAGGCTCCTGCTTCCTGGGAAACCCGACAAGTCCGGCCGCCCCATTAGCTTCATG
GTGGTTTTCATCACCCCCAACCCCCTGAGCAAGATTTCCTGGGTCAACAGGTTACATTTGGCCAAAATCGGACTCCGGGAGGAGAACCAG
CCAGGCTGGCTATGCCCGGATGAGGACAAGAAGAGCAAAGCCCCATTCTGGTGCCCGATCCTGGCCTGCTGCATCCCTGCCTTCTCCTCC
CGGGCACTCAGCCTGCAGCTTGGGGCCCTGGTCCACAGTCCTGTCAACTGTCCCCTGCTGGGTTTCTCAGCAGTCAGCACCTCCCTTCCA
CAGGGCTACCTCTGGGTCGGGGGCGGACAGGAAGGCGCAGGGGGCCAGGTGGAAATCTTTTCCTTGAACCGGCCCTCGCCCCGCACCGTC
AAGTCCTTCCCACTGGCAGCCCCTGTGCTCTGCATGGAGTATATCCCGGAGCTGGAGGAGGAGGCGGAGAGCAGAGACGAGAGCCCGACA
GTTGCTGACCCCTCGGCCACGGTGCATCCAACCATCTGCCTCGGGCTCCAGGATGGCAGCATCCTCCTCTACAGCAGTGTGGACACTGGC
ACCCAGTGCCTGGTGAGCTGCAGGAGCCCAGGTCTGCAGCCTGTGCTCTGCCTGCGACACAGCCCCTTCCACCTGCTCGCTGGCCTGCAG
GATGGGACCCTTGCTGCTTACCCTCGGACCAGCGGAGGTGTCCTGTGGGACCTGGAGAGCCCTCCCGTGTGCCTGACTGTGGGGCCCGGG
CCTGTCCGCACCCTGTTGAGCCTGGAGGATGCCGTGTGGGCCAGCTGTGGGCCCTGGGTCACTGTCCTGGAAGCCACCACCCTGCAGCCT
CAGACCAACCCTGGAATGGTCCCCAGCCATGGATTCAGTCCCAGATCTTATTTCTTTGACAACCCTCGAAGATATGACAGTGATGATGAC
CTTGCCTGGAACATTGCCCCTCAGGGACTTCAGGGAGGTTTTGCTCCAGATTACTATGATTGGGGACAACAAACTAACAGCTTCCTGGCA
CAAGCAGGAACTTTGCAAGACTCAACTTTGGATCCTGACAAACCAAGCCTTGGGTAGCATCAGTTAACAGTTTTATGGACGATTCCTCAG
ATGAAAAGCTTCAGAAAAGCATAGTGACAGCTGAATTTTTAGGGCACTTTTCCTTAAGAAATAGAACTTGATTTTTATTTGTTACAGGTT
TCCAATGGCCCCATAGGAATAAGCAATAATGTAGACTGATAAACCCTTATTTTAGTACTAAAGAGGGAGCCTTGCTATTTCAGTGGGTAT
AATTTAAACTTTTTAAAGAAAATCTGTACTTTTATAAAGATGTATTTTGTATAACTTAAATAATAATGCTAAAGTATACTAGGGTTTTTT
TTTCTTGAGAATGTTACTGCAATCATGTTGTAGTTTGCACAGACTTTTATGCATAATTCACTTTAAAAATATAGAATATATGGTCTAATA
GTTTTTTAAAGCTTTTGGACTAAAGTATTCCACAAATCTTACCTCTTTAGGTCACTGATGGTCACTCCGATTCTGAGTGCCACATTGGTA
GACTCCTAAAATACAGTTGACAACTTAGCCAATTGCAACTCCAGTGTTGATAATTAAAATGAAATGGTAAAGCAGCAGACTGTAAGGTCT
TTAGAGATTTTTTTTTTAAGGTTCAGGCCGTAGGTTCCTCAAGGAATCTCTTAAGTTTTGCCCAAAGACTGGTACTTCCTTTCAGTAGGG

>6180_6180_5_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000434513_GPR137B_chr1_236368426_ENST00000366592_length(amino acids)=1076AA_BP=999
MMASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERDTDPPLIHLDSIPVTDPDPAAAPPGTGVPA
WVSNGDAADAAFSGARHSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSE
DSGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYDCKMTQLMKAAKSGTKDGLEKTRMAVMRKV
SFLHRKDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKC
QVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRV
TLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLL
CETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKK
ASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDK
SGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGF
SAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQDGSIL
LYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPWVTV

--------------------------------------------------------------
>6180_6180_6_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000452522_GPR137B_chr1_236368426_ENST00000366592_length(transcript)=4033nt_BP=3051nt
GCGCCGTCCCGGCCATGGGCGCCCGCGGCGGCCTGCGGAGCTGGAGGCGCGGCGCCGGCCGCCAGGCGCCTTTGTGAGCGGCGCGGACGA
CAAAGGCGCGGGCCCGGGCAGCCGAGGTGTGTAGCTGGGACGGTGCTGGTCTGAGCTGGACCTTGTCTGATGGCTTCCTCCAACCCTCCT
CCACAGCCTGCCATAGGAGATCAGCTGGTTCCAGGAGTCCCAGGCCCCTCCTCTGAGGCAGAGGACGACCCAGGAGAGGCGTTTGAGTTT
GATGACAGTGATGATGAAGAGGACACCAGCGCAGCCCTGGGCGTCCCCAGCCTTGCTCCTGAGAGGGACACAGACCCCCCACTGATCCAC
TTGGACTCCATCCCTGTCACTGACCCAGACCCAGCAGCTGCTCCACCCGGCACAGGGGTGCCAGCCTGGGTGAGCAATGGGGATGCAGCG
GACGCAGCCTTCTCCGGGGCCCGGCACTCCAGCTGGAAGCGGAAGAGTTCCCGTCGCATTGACCGGTTCACTTTCCCCGCCCTGGAAGAG
GATGTGATTTATGACGACGTCCCCTGCGAGAGCCCAGATGCGCATCAGCCCGGGGCAGAGAGGAACCTGCTCTACGAGGATGCGCACCGG
GCTGGGGCCCCTCGGCAGGCGGAGGACCTAGGCTGGAGCTCCAGTGAGTTCGAGAGCTACAGCGAGGACTCGGGGGAGGAGGCCAAGCCG
GAGGTCGAGGTCGAGCCCGCCAAGCACCGAGTGTCCTTCCAGCCCAAGATGACCCAGCTCATGAAGGCCGCCAAGAGCGGGACCAAGGAT
GGGCTGGAGAAGACACGGATGGCCGTGATGCGCAAAGTCTCCTTCCTGCACAGGAAGGACGTCCTCGGTGACTCGGAGGAGGAGGACATG
GGGCTCCTGGAGGTCAGCGTTTCGGACATCAAGCCCCCAGCCCCAGAGCTGGGCCCCATGCCAGAGGGCCTGAGCCCTCAGCAGGTGGTC
CGGAGGCATATCCTGGGCTCCATCGTGCAGAGCGAAGGCAGCTACGTGGAGTCTCTGAAGCGGATACTCCAGGACTACCGCAACCCCCTG
ATGGAGATGGAGCCCAAGGCGCTGAGCGCCCGCAAGTGCCAGGTGGTGTTCTTCCGCGTGAAGGAGATCCTGCACTGCCACTCCATGTTC
CAGATCGCCCTGTCCTCCCGCGTGGCTGAGTGGGATTCCACCGAGAAGATCGGGGACCTCTTCGTGGCCTCGTTTTCCAAGTCCATGGTG
CTAGATGTGTACAGTGACTACGTGAACAACTTCACCAGTGCCATGTCCATCATCAAGAAGGCCTGCCTCACCAAGCCTGCCTTCCTCGAG
TTCCTCAAGCGACGGCAGGTGTGCAGCCCAGACCGTGTCACCCTCTACGGGCTGATGGTCAAGCCCATCCAGAGGTTCCCACAGTTCATA
CTCCTGCTTCAGGACATGCTGAAGAACACCCCCAGGGGCCATCCGGACAGGCTGTCGCTGCAGCTGGCCCTCACAGAGCTGGAGACGCTG
GCTGAGAAGCTGAACGAGCAGAAGCGGCTGGCTGACCAGGTGGCTGAGATCCAGCAGCTGACCAAGAGCGTCAGTGACCGCAGCAGCCTC
AACAAGCTGTTGACCTCAGGCCAGCGGCAGCTGCTCCTGTGTGAGACGTTGACGGAGACCGTGTACGGTGACCGCGGGCAGCTAATTAAG
TCCAAGGAGCGTCGGGTCTTCCTGCTCAACGACATGCTTGTCTGTGCCAACATCAACTTCAAGCCTGCCAACCACAGGGGCCAGCTGGAG
ATCAGCAGCCTGGTGCCCCTGGGGCCCAAGTATGTGGTGAAGTGGAACACGGCGCTGCCCCAGGTGCAGGTGGTGGAGGTGGGCCAGGAC
GGTGGCACCTATGACAAGGACAATGTGCTCATCCAGCACTCAGGCGCCAAGAAGGCCTCTGCCTCAGGGCAGGCTCAGAATAAGGTGTAC
CTCGGCCCCCCACGCCTCTTCCAGGAGCTGCAGGACCTGCAGAAGGACCTGGCCGTGGTGGAGCAGATCACGCTTCTCATCAGCACGCTG
CACGGCACCTACCAGAACCTGAACATGACTGTGGCTCAAGACTGGTGCCTGGCCCTGCAGAGGCTGATGCGGGTGAAGGAGGAAGAGATC
CACTCGGCCAACAAGTGCCGTCTCAGGCTCCTGCTTCCTGGGAAACCCGACAAGTCCGGCCGCCCCATTAGCTTCATGGTGGTTTTCATC
ACCCCCAACCCCCTGAGCAAGATTTCCTGGGTCAACAGGTTACATTTGGCCAAAATCGGACTCCGGGAGGAGAACCAGCCAGGCTGGCTA
TGCCCGGATGAGGACAAGAAGAGCAAAGCCCCATTCTGGTGCCCGATCCTGGCCTGCTGCATCCCTGCCTTCTCCTCCCGGGCACTCAGC
CTGCAGCTTGGGGCCCTGGTCCACAGTCCTGTCAACTGTCCCCTGCTGGGTTTCTCAGCAGTCAGCACCTCCCTTCCACAGGGCTACCTC
TGGGTCGGGGGCGGACAGGAAGGCGCAGGGGGCCAGGTGGAAATCTTTTCCTTGAACCGGCCCTCGCCCCGCACCGTCAAGTCCTTCCCA
CTGGCAGCCCCTGTGCTCTGCATGGAGTATATCCCGGAGCTGGAGGAGGAGGCGGAGAGCAGAGACGAGAGCCCGACAGTTGCTGACCCC
TCGGCCACGGTGCATCCAACCATCTGCCTCGGGCTCCAGGATGGCAGCATCCTCCTCTACAGCAGTGTGGACACTGGCACCCAGTGCCTG
GTGAGCTGCAGGAGCCCAGGTCTGCAGCCTGTGCTCTGCCTGCGACACAGCCCCTTCCACCTGCTCGCTGGCCTGCAGGATGGGACCCTT
GCTGCTTACCCTCGGACCAGCGGAGGTGTCCTGTGGGACCTGGAGAGCCCTCCCGTGTGCCTGACTGTGGGGCCCGGGCCTGTCCGCACC
CTGTTGAGCCTGGAGGATGCCGTGTGGGCCAGCTGTGGGCCCTGGGTCACTGTCCTGGAAGCCACCACCCTGCAGCCTCAGACCAACCCT
GGAATGGTCCCCAGCCATGGATTCAGTCCCAGATCTTATTTCTTTGACAACCCTCGAAGATATGACAGTGATGATGACCTTGCCTGGAAC
ATTGCCCCTCAGGGACTTCAGGGAGGTTTTGCTCCAGATTACTATGATTGGGGACAACAAACTAACAGCTTCCTGGCACAAGCAGGAACT
TTGCAAGACTCAACTTTGGATCCTGACAAACCAAGCCTTGGGTAGCATCAGTTAACAGTTTTATGGACGATTCCTCAGATGAAAAGCTTC
AGAAAAGCATAGTGACAGCTGAATTTTTAGGGCACTTTTCCTTAAGAAATAGAACTTGATTTTTATTTGTTACAGGTTTCCAATGGCCCC
ATAGGAATAAGCAATAATGTAGACTGATAAACCCTTATTTTAGTACTAAAGAGGGAGCCTTGCTATTTCAGTGGGTATAATTTAAACTTT
TTAAAGAAAATCTGTACTTTTATAAAGATGTATTTTGTATAACTTAAATAATAATGCTAAAGTATACTAGGGTTTTTTTTTCTTGAGAAT
GTTACTGCAATCATGTTGTAGTTTGCACAGACTTTTATGCATAATTCACTTTAAAAATATAGAATATATGGTCTAATAGTTTTTTAAAGC
TTTTGGACTAAAGTATTCCACAAATCTTACCTCTTTAGGTCACTGATGGTCACTCCGATTCTGAGTGCCACATTGGTAGACTCCTAAAAT
ACAGTTGACAACTTAGCCAATTGCAACTCCAGTGTTGATAATTAAAATGAAATGGTAAAGCAGCAGACTGTAAGGTCTTTAGAGATTTTT
TTTTTAAGGTTCAGGCCGTAGGTTCCTCAAGGAATCTCTTAAGTTTTGCCCAAAGACTGGTACTTCCTTTCAGTAGGGCGCTAATGTATA

>6180_6180_6_ARHGEF10L-GPR137B_ARHGEF10L_chr1_17991090_ENST00000452522_GPR137B_chr1_236368426_ENST00000366592_length(amino acids)=1042AA_BP=965
MMASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERDTDPPLIHLDSIPVTDPDPAAAPPGTGVPA
WVSNGDAADAAFSGARHSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSE
DSGEEAKPEVEVEPAKHRVSFQPKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPE
GLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFV
ASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQL
ALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKP
ANHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQ
ITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLR
EENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPS
PRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLL
AGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPWVTVLEATTLQPQTNPGMVPSHGFSPRSYFFDNPRRYD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGEF10L-GPR137B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGEF10L-GPR137B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGEF10L-GPR137B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource