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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C14orf105-PTPN2 (FusionGDB2 ID:HG55195TG5771)

Fusion Gene Summary for C14orf105-PTPN2

check button Fusion gene summary
Fusion gene informationFusion gene name: C14orf105-PTPN2
Fusion gene ID: hg55195tg5771
HgeneTgene
Gene symbol

C14orf105

PTPN2

Gene ID

55195

5771

Gene namecoiled-coil domain containing 198protein tyrosine phosphatase non-receptor type 2
SynonymsC14orf105PTN2|PTPT|TC-PTP|TCELLPTP|TCPTP
Cytomap('C14orf105')('PTPN2')

14q22.3

18p11.21

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein CCDC198uncharacterized protein C14orf105tyrosine-protein phosphatase non-receptor type 2T-cell protein tyrosine phosphatase
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000422976, ENST00000216445, 
ENST00000526336, ENST00000534126, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 9 X 5=360
# samples 19
** MAII scorelog2(1/1*10)=3.32192809488736log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C14orf105 [Title/Abstract] AND PTPN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC14orf105(57942300)-PTPN2(12859253), # samples:3
Anticipated loss of major functional domain due to fusion event.C14orf105-PTPN2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8683-01AC14orf105chr14

57942300

-PTPN2chr18

12859253

-
ChimerDB4STADTCGA-HU-A4GH-01AC14orf105chr14

57942300

-PTPN2chr18

12859253

-
ChimerDB4UVMTCGA-V4-A9EXC14orf105chr14

57942300

-PTPN2chr18

12859253

-


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Fusion Gene ORF analysis for C14orf105-PTPN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000422976ENST00000589086C14orf105chr14

57942300

-PTPN2chr18

12859253

-
5CDS-intronENST00000422976ENST00000591497C14orf105chr14

57942300

-PTPN2chr18

12859253

-
Frame-shiftENST00000422976ENST00000309660C14orf105chr14

57942300

-PTPN2chr18

12859253

-
Frame-shiftENST00000422976ENST00000327283C14orf105chr14

57942300

-PTPN2chr18

12859253

-
Frame-shiftENST00000422976ENST00000353319C14orf105chr14

57942300

-PTPN2chr18

12859253

-
Frame-shiftENST00000422976ENST00000591115C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-3CDSENST00000216445ENST00000309660C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-3CDSENST00000216445ENST00000327283C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-3CDSENST00000216445ENST00000353319C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-3CDSENST00000216445ENST00000591115C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-3CDSENST00000526336ENST00000309660C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-3CDSENST00000526336ENST00000327283C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-3CDSENST00000526336ENST00000353319C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-3CDSENST00000526336ENST00000591115C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-3CDSENST00000534126ENST00000309660C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-3CDSENST00000534126ENST00000327283C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-3CDSENST00000534126ENST00000353319C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-3CDSENST00000534126ENST00000591115C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-5UTRENST00000216445ENST00000589086C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-5UTRENST00000526336ENST00000589086C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-5UTRENST00000534126ENST00000589086C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-intronENST00000216445ENST00000591497C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-intronENST00000526336ENST00000591497C14orf105chr14

57942300

-PTPN2chr18

12859253

-
intron-intronENST00000534126ENST00000591497C14orf105chr14

57942300

-PTPN2chr18

12859253

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for C14orf105-PTPN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for C14orf105-PTPN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:57942300/:12859253)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for C14orf105-PTPN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for C14orf105-PTPN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C14orf105-PTPN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C14orf105-PTPN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0003873Rheumatoid Arthritis1CTD_human
TgeneC0009324Ulcerative Colitis1CTD_human;GENOMICS_ENGLAND
TgeneC0010346Crohn Disease1CTD_human
TgeneC0023492Leukemia, T-Cell1CTD_human
TgeneC0156147Crohn's disease of large bowel1CTD_human
TgeneC0267380Crohn's disease of the ileum1CTD_human
TgeneC0678202Regional enteritis1CTD_human
TgeneC0949272IIeocolitis1CTD_human
TgeneC1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneC2931171Juvenile pauciarticular chronic arthritis1ORPHANET