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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARL8B-CLASP2 (FusionGDB2 ID:HG55207TG23122)

Fusion Gene Summary for ARL8B-CLASP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARL8B-CLASP2
Fusion gene ID: hg55207tg23122
HgeneTgene
Gene symbol

ARL8B

CLASP2

Gene ID

55207

23122

Gene nameADP ribosylation factor like GTPase 8Bcytoplasmic linker associated protein 2
SynonymsARL10C|Gie1-
Cytomap('ARL8B')('CLASP2')

3p26.1

3p22.3

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor-like protein 8BADP-ribosylation factor-like 10CADP-ribosylation factor-like 8BADP-ribosylation factor-like protein 10Cnovel small G protein indispensable for equal chromosome segregation 1CLIP-associating protein 2CLIP-associating protein CLASP2multiple asters (Mast)-like homolog 2protein Orbit homolog 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000256496, ENST00000419534, 
ENST00000468010, 
Fusion gene scores* DoF score4 X 1 X 7=2815 X 10 X 9=1350
# samples 915
** MAII scorelog2(9/28*10)=1.68449817427207
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/1350*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARL8B [Title/Abstract] AND CLASP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARL8B(5164273)-CLASP2(33738425), # samples:3
Anticipated loss of major functional domain due to fusion event.ARL8B-CLASP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARL8B-CLASP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARL8B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CLASP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PCPGTCGA-W2-A7HB-01AARL8Bchr3

5164273

-CLASP2chr3

33738425

-
ChimerDB4PCPGTCGA-W2-A7HB-01AARL8Bchr3

5164273

+CLASP2chr3

33738425

-


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Fusion Gene ORF analysis for ARL8B-CLASP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000256496ENST00000307312ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-5UTRENST00000419534ENST00000307312ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-intronENST00000256496ENST00000313350ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-intronENST00000256496ENST00000333778ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-intronENST00000256496ENST00000359576ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-intronENST00000256496ENST00000461133ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-intronENST00000256496ENST00000480013ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-intronENST00000256496ENST00000482896ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-intronENST00000256496ENST00000487200ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-intronENST00000256496ENST00000539981ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-intronENST00000419534ENST00000313350ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-intronENST00000419534ENST00000333778ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-intronENST00000419534ENST00000359576ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-intronENST00000419534ENST00000461133ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-intronENST00000419534ENST00000480013ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-intronENST00000419534ENST00000482896ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-intronENST00000419534ENST00000487200ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
5CDS-intronENST00000419534ENST00000539981ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
In-frameENST00000256496ENST00000399362ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
In-frameENST00000256496ENST00000468888ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
In-frameENST00000419534ENST00000399362ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
In-frameENST00000419534ENST00000468888ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
intron-3CDSENST00000468010ENST00000399362ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
intron-3CDSENST00000468010ENST00000468888ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
intron-5UTRENST00000468010ENST00000307312ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
intron-intronENST00000468010ENST00000313350ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
intron-intronENST00000468010ENST00000333778ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
intron-intronENST00000468010ENST00000359576ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
intron-intronENST00000468010ENST00000461133ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
intron-intronENST00000468010ENST00000480013ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
intron-intronENST00000468010ENST00000482896ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
intron-intronENST00000468010ENST00000487200ARL8Bchr3

5164273

+CLASP2chr3

33738425

-
intron-intronENST00000468010ENST00000539981ARL8Bchr3

5164273

+CLASP2chr3

33738425

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000256496ARL8Bchr35164273+ENST00000468888CLASP2chr333738425-710536924647181490
ENST00000256496ARL8Bchr35164273+ENST00000399362CLASP2chr333738425-710236924647151489
ENST00000419534ARL8Bchr35164273+ENST00000468888CLASP2chr333738425-702929317046421490
ENST00000419534ARL8Bchr35164273+ENST00000399362CLASP2chr333738425-702629317046391489

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000256496ENST00000468888ARL8Bchr35164273+CLASP2chr333738425-0.0002541970.9997458
ENST00000256496ENST00000399362ARL8Bchr35164273+CLASP2chr333738425-0.000248880.99975115
ENST00000419534ENST00000468888ARL8Bchr35164273+CLASP2chr333738425-0.0002303750.9997696
ENST00000419534ENST00000399362ARL8Bchr35164273+CLASP2chr333738425-0.0002255740.9997744

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Fusion Genomic Features for ARL8B-CLASP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARL8B-CLASP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:5164273/chr3:33738425)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARL8Bchr3:5164273chr3:33738425ENST00000256496+171_1941187.0IntramembraneNote=Note%3DMediates targeting to membranes
HgeneARL8Bchr3:5164273chr3:33738425ENST00000256496+1729_3541187.0Nucleotide bindingNote=GTP
TgeneCLASP2chr3:5164273chr3:33738425ENST000003133500131104_11080432.0Compositional biasNote=Poly-Leu
TgeneCLASP2chr3:5164273chr3:33738425ENST00000313350013310_5870432.0Compositional biasNote=Ser-rich
TgeneCLASP2chr3:5164273chr3:33738425ENST000003133500131017_12940432.0RegionNote=Required for cortical localization
TgeneCLASP2chr3:5164273chr3:33738425ENST0000031335001360_3110432.0RegionTOG 1
TgeneCLASP2chr3:5164273chr3:33738425ENST00000313350013649_8810432.0RegionTOG 2
TgeneCLASP2chr3:5164273chr3:33738425ENST000003133500131054_10910432.0RepeatHEAT 6
TgeneCLASP2chr3:5164273chr3:33738425ENST000003133500131098_11350432.0RepeatHEAT 7
TgeneCLASP2chr3:5164273chr3:33738425ENST000003133500131216_12530432.0RepeatHEAT 8
TgeneCLASP2chr3:5164273chr3:33738425ENST00000313350013173_2080432.0RepeatHEAT 1
TgeneCLASP2chr3:5164273chr3:33738425ENST00000313350013209_2450432.0RepeatHEAT 2
TgeneCLASP2chr3:5164273chr3:33738425ENST00000313350013250_2870432.0RepeatHEAT 3
TgeneCLASP2chr3:5164273chr3:33738425ENST00000313350013710_7470432.0RepeatHEAT 4
TgeneCLASP2chr3:5164273chr3:33738425ENST00000313350013772_8090432.0RepeatHEAT 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARL8Bchr3:5164273chr3:33738425ENST00000256496+17130_13341187.0Nucleotide bindingNote=GTP
HgeneARL8Bchr3:5164273chr3:33738425ENST00000256496+1771_7541187.0Nucleotide bindingGTP


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Fusion Gene Sequence for ARL8B-CLASP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6634_6634_1_ARL8B-CLASP2_ARL8B_chr3_5164273_ENST00000256496_CLASP2_chr3_33738425_ENST00000399362_length(transcript)=7102nt_BP=369nt
GGATTGGCCGCGCCGCTCTTGCCGTGGGTGCCGACGGCGGCGCCGGGACGGGCGTGGGGGGTAGGGCGAGTCATATGATCCGCTCGGCTT
CCTGGGTCTGGCTGCTGCCGCCCGCCGGTGTCCGCCCGTGTCGCGCCGGGGCACCAAGGAGCCGTTGGAGGGTCCGGGCGGAGGCCCGCT
CGTGTGGAAGTCGTCGACGCCGCCGCTCGTCCGTCCTCCCGTCCGTTCTCGCTCCCGGCCGCCATCATGCTGGCGCTCATCTCCCGCCTG
CTGGACTGGTTCCGTTCGCTCTTCTGGAAGGAAGAGATGGAGCTGACGCTCGTGGGGCTGCAGTACTCGGGCAAGACCACCTTCGTCAAT
GTCATCGCGGTATCATTAATGGGATTGGAAATTTTAAGTGCCTTTGTGGACAGATTATCAACACGCTTTAAATCCTATGTAGCAATGGTT
ATTGTAGCTTTAATAGACAGAATGGGAGATGCCAAAGACAAGGTTCGAGATGAAGCTCAGACTCTGATATTGAAGTTAATGGATCAAGTA
GCACCACCTATGTACATTTGGGAGCAGTTGGCTTCTGGTTTTAAACACAAGAATTTTCGATCTCGAGAAGGCGTGTGTCTGTGTCTTATT
GAAACCTTAAACATTTTTGGGGCTCAGCCACTAGTCATCAGCAAATTGATACCACATTTGTGTATCCTGTTTGGAGACTCCAACAGTCAG
GTGAGAGATGCTGCAATATTGGCTATAGTGGAGATTTATAGACATGTGGGAGAAAAAGTGAGGATGGATCTTTATAAGAGAGGAATTCCC
CCTGCTAGATTAGAAATGATATTTGCCAAATTTGATGAAGTGCAAAGTTCAGGCGGTATGATTTTGAGTGTCTGCAAAGATAAAAGCTTC
GATGATGAAGAATCAGTGGATGGAAATAGGCCATCATCAGCTGCATCAGCCTTCAAGGTTCCTGCACCTAAAACATCCGGAAATCCTGCC
AACAGTGCAAGGAAGCCTGGTTCAGCAGGTGGCCCTAAGGTTGGAGGTGCTTCTAAGGAAGGAGGTGCTGGAGCAGTTGATGAAGATGAT
TTTATAAAAGCTTTTACAGATGTCCCTTCTATTCAGATTTATTCTAGTCGAGAACTCGAAGAAACATTAAATAAAATCAGGGAAATTTTG
TCAGATGATAAACATGACTGGGATCAGCGTGCCAATGCACTGAAGAAAATTCGATCACTGCTTGTTGCTGGAGCTGCACAGTATGATTGC
TTTTTTCAACATTTACGATTGTTGGATGGAGCACTTAAACTTTCAGCTAAGGATCTTAGATCCCAGGTGGTTAGAGAAGCTTGTATTACT
GTAGCCCACCTTTCAACAGTTTTGGGAAACAAGTTTGATCATGGCGCTGAAGCCATTGTACCTACACTTTTTAATCTCGTCCCCAATAGT
GCAAAAGTCATGGCAACTTCTGGATGTGCAGCAATCAGATTTATCATTCGGCATACTCATGTACCCAGACTTATACCTTTAATAACAAGC
AATTGCACATCAAAATCAGTTCCCGTGAGGAGACGTTCATTTGAATTTTTAGATTTATTGTTGCAAGAGTGGCAGACTCATTCATTGGAA
AGACATGCAGCCGTCTTGGTTGAAACTATTAAAAAGGGAATTCATGATGCTGACGCTGAGGCCAGAGTGGAGGCAAGAAAGACATACATG
GGTCTTAGAAACCACTTTCCTGGTGAAGCTGAAACATTATATAATTCCCTTGAGCCATCTTATCAGAAGAGTCTTCAAACTTACTTAAAG
AGTTCTGGCAGTGTAGCATCTCTTCCACAATCAGACAGGTCCTCATCCAGCTCACAGGAAAGTCTCAATCGCCCTTTTTCTTCCAAATGG
TCTACAGCAAATCCATCAACTGTGGCTGGAAGAGTATCAGCAGGCAGCAGCAAAGCCAGTTCCCTTCCAGGAAGCCTGCAGCGTTCACGA
AGTGACATTGATGTGAATGCTGCTGCAGGTGCCAAGGCACATCATGCTGCTGGACAGTCTGTGCGAAGCGGGCGCTTAGGTGCAGGTGCC
CTGAATGCAGGTTCCTATGCGTCACTAGAGGATACTTCTGACAAGCTGGATGGAACAGCATCTGAAGATGGCCGGGTGAGAGCAAAACTT
TCAGCACCACTTGCTGGCATGGGAAATGCCAAGGCAGATTCTAGAGGAAGAAGTCGAACAAAAATGGTGTCTCAATCACAGCCTGGTAGC
CGGTCTGGGTCTCCAGGAAGAGTTCTGACCACAACAGCCCTGTCCACTGTGAGCTCTGGTGTTCAAAGAGTCCTGGTCAATTCAGCCTCA
GCACAAAAAAGAAGCAAGATACCACGGAGCCAGGGCTGTAGCAGAGAGGCTAGTCCATCTAGGCTTTCAGTGGCCCGAAGCAGTCGTATT
CCTCGACCAAGTGTGAGTCAAGGATGCAGCCGGGAAGCTAGTCGGGAGAGCAGCAGAGACACAAGTCCTGTTCGCTCTTTTCAGCCCCTC
GGTCCAGGTTATGGGATCAGCCAATCAAGTCGACTGTCGTCTTCTGTTAGTGCCATGCGAGTCCTGAACACAGGTTCTGATGTGGAGGAG
GCGGTGGCAGATGCCTTGCTCTTAGGAGACATACGGACTAAGAAAAAACCAGCTCGAAGAAGATATGAATCATATGGAATGCATTCAGAT
GATGACGCCAACAGCGATGCATCTAGTGCTTGTTCAGAACGCTCCTATAGTTCTCGAAATGGTAGTATTCCTACATATATGAGGCAGACG
GAAGATGTGGCAGAAGTCCTCAATAGATGTGCTAGTTCCAATTGGTCAGAAAGGAAAGAAGGCCTCCTAGGTCTGCAGAACTTATTAAAA
AATCAGAGAACACTAAGTCGAGTTGAACTGAAAAGATTATGTGAAATTTTCACAAGAATGTTTGCTGACCCTCATGGCAAGGTATTCAGC
ATGTTTTTGGAGACTCTAGTGGATTTCATACAAGTCCACAAAGATGATCTTCAAGATTGGTTGTTTGTACTGCTGACACAACTACTAAAA
AAAATGGGTGCTGATTTGCTTGGATCTGTTCAGGCAAAAGTTCAGAAAGCCCTTGATGTTACAAGAGAGTCTTTTCCAAATGATCTTCAG
TTCAATATTCTAATGAGATTTACAGTTGATCAGACCCAGACACCAAGCTTAAAGGTGAAGGTTGCTATCCTTAAATACATAGAAACTCTG
GCCAAACAGATGGATCCAGGAGATTTTATAAATTCCAGTGAAACTCGCCTAGCAGTGTCTCGGGTCATCACTTGGACAACAGAACCCAAA
AGTTCTGATGTTCGGAAGGCAGCACAGTCAGTGCTGATTTCATTATTTGAACTCAATACCCCAGAGTTTACAATGTTATTAGGAGCTTTA
CCAAAAACTTTTCAGGATGGTGCTACCAAGCTTCTTCATAATCACCTTCGAAACACTGGCAATGGAACCCAGAGTTCCATGGGGAGTCCT
TTGACAAGACCAACACCACGATCACCAGCTAACTGGTCCAGTCCTCTTACTTCTCCTACCAATACATCACAGAATACTTTATCTCCAAGT
GCATTTGATTATGACACAGAAAATATGAACTCTGAAGATATTTATAGCTCTCTTAGAGGTGTCACTGAAGCAATCCAGAATTTCAGCTTC
CGTAGCCAAGAAGATATGAATGAGCCATTGAAAAGGGATTCTAAAAAAGATGATGGCGATTCAATGTGTGGTGGTCCTGGGATGTCTGAC
CCAAGAGCAGGAGGTGATGCTACTGACTCAAGTCAAACAGCTCTTGATAATAAAGCTTCATTGCTCCATTCAATGCCTACTCACTCCTCT
CCACGCTCTCGAGACTATAATCCATATAACTATTCAGATAGCATCAGTCCCTTCAACAAGTCTGCCCTCAAGGAAGCCATGTTTGATGAT
GATGCTGACCAGTTTCCTGACGATCTTTCCCTAGATCATTCTGACCTAGTTGCAGAGTTGTTGAAGGAGCTGTCTAACCATAATGAGCGT
GTAGAAGAAAGAAAAATTGCCCTCTATGAACTTATGAAACTGACACAGGAAGAATCTTTTAGTGTTTGGGATGAACACTTCAAAACAATA
TTGCTTTTATTGCTTGAAACGCTTGGAGATAAAGAGCCTACAATCAGGGCTTTGGCATTAAAGGTTTTAAGAGAAATCCTAAGGCATCAA
CCAGCAAGATTTAAAAACTATGCAGAATTGACTGTCATGAAAACATTGGAAGCACATAAAGATCCTCATAAGGAGGTGGTGAGATCTGCT
GAGGAAGCGGCATCAGTGTTGGCCACTTCAATTAGTCCAGAGCAGTGCATCAAAGTGCTTTGTCCTATCATTCAAACTGCAGACTACCCA
ATTAATCTGGCTGCAATCAAAATGCAAACAAAAGTGATAGAGAGAGTGTCCAAGGAAACCCTAAACCTGCTTTTGCCAGAGATTATGCCA
GGTCTAATACAGGGTTATGATAATTCAGAGAGCAGTGTTCGGAAAGCTTGTGTCTTCTGCCTGGTGGCTGTTCATGCGGTAATTGGTGAT
GAACTAAAACCACATCTCAGTCAACTTACTGGCAGTAAAATGAAGCTACTGAATCTTTACATCAAACGTGCACAAACAGGTTCTGGAGGA
GCTGATCCCACTACTGATGTTTCTGGACAAAGTTAGTGAAGCTCATCACAGCGAACCAGGTCTCTCAAAAGAAAGGACAGATAGACCACC
CTCATCAATGAAAGGAAGTTCTCAAACACATCCTTTGGAACTTACTATTGTTTCCCAGTTTTAGTTTTTTGTTTCGTTTCGTTTTGTATT
TTCTGTAACAGAGGACTATCCTCAGTCTGCATGTAACTTTTATGATAGTTATTCCAAATTCAAGAAGAAGCAGTATTAACATCAATTGAT
CGACACAAAGTAATTTTTAATTTAATTCATCATTTCACATGTTTGTACTTTGTCTTCCCATTAACCTTTGCCAGTGTTATGATTGTATAA
ATTTTTTTAAATGCTGGTTAAACAGGAATGCTTAAAGCTTTAAAAGTTTAACAGTCTAAAACATTTTTGCTTTTATTCAACTGCAGAATA
ATATTTTTATTGCTACTTTGAGTTTTGTTTCGTATCATGTCCTATGCTAGAAATATTTAAATGATGTGAAACAAAGCAGGACTAATTTGA
ACTACAGCTGGACTCCGTTTGTGTGATGGTGATACATGTCATTAGTTGCAACTTCTTTGGGGTGATCTATAGTTTGAAAACTAAAACCTC
AAAGACAGATGTTACAGAATCAGCCAGTTCTGTAAAACTGATATTGTCTATTGGTTATTGATCTTGCCATCTTTATTTAAAACCATGTCC
CTTCTATGATCCCTTAAGAAAGCTGCACCAAATCATCTGCCTGTTTTTTCTTGATACTTACTGAAATAGAAGGTTTTATTGCAGGGTTTA
TTTTGGTTTGTTTATATCTTTGTTGTGAATGATGCTTTTTTGTATTTATTAATATCAAATTCACTTATGAATAAACTTGATAATGGAAAC
GGACAAAAAAAATCAAGTGCGTGTGTGTCCTTGACCGTCTTCTGTTTCTCACGTAATAAACAAATTATCGAGACATGGGAGTGACCAGCA
CCTTTTCTTTAAATGGTGGAACCTGGTTTCCTTTTACCATGAAATTGTCTTACTTGAAAATATTGATCCTGATGAGAGAGAAGATGGTGC
CAAGGCTGTCTTTGTATAATGGGCTCAAATTCTCTACCTCTTCAGGGCTAATACTTTTAACTGAGCTGCTGCCTATAGTGTCTTTTGGAA
AACTACTTAAAGGGTGATTTTCTGTTACTTTTTAGCAAATTTTTTTAATCACCTCTTGCTACACCCATTCTTTTCATGTGCAGCCGACTC
AAAAATTACCAGTTTTGGTGAAAGGCTAAATTAGATAATTTGGAACCAGGATACTAATGATTTCTCATCTTTACTTTTTTTTAATCCTAA
TATAAAGTGAATTTGATTGAAAAGGCAAATAGCTATTAGGGAAGCAGTTTGCCATTGTTGCAGAGTTATCTGTACTTTGTTTAACTGAAA
AAAATGTAGAAATATATGTAAAGAATTTAAGACAAGAGTACTGAATGGATGATTTGTCATAGGCTTTCCCCTTTCTTTCTGTTCTAGCAG
CAGGAAAAGTTTCTCTATATCCTCTCCCTCTACCTGTAACAATTTTGTTTTCTACTGTTAATTACATTGTGTATTTATAGTTCTATGCTT
ACTGTTGTGCATATACTGGCAATAAAACTGTACATAACATTACTTGAAAAAGTTAATAATGTATATCAGTTTTTCTGTCTCACTGTGTAA
CAAGTCACTCAGTTTTATTTTAACTTTAGACGGTCTTGTATCAGTGGTGGTCTCTTGAATTTTGTAAGTTCATCTGAGGAGAAAAGATTT
TTCAGGTGTAGCTACCACAATCAAAGGTATATAGCTACATACGCATGTATATATTACAGCTTATCTGTAAGAAGAAAATGCATTTTAAAC
ACAACTCTTCTCAGTAGCATTTTATGACCTTTGGATATGTTTGTAATCATTTCGAATCAAAATATTGATTTAATTTTGACCTCTGGTTTA
AGATACTGCTTTAACTACTGTTGACAACCAAGTAGAGTGACTTAAGCTGAACAGTAACTAACTGGAAAATTAGATAAGCACCTGGCATCT
AATGGCAGGCAGGCACTCAAGAAATGAATTAACTACATAATGGAAAAGTATGGTTTAATGTGTCCAAATGAAAGCTAGTAGATGTAAACA
TGGAAAAATTGTGTTTACAATTTTATAATCTCAGTTGATAAGACTATAAGAAAGCTGATTATTTAAATCACTATATACAATACACCCTTA
ATTTGTTCATTCCAGAAACATACTGAGATGTCAGCTACTTAAAAATGGTCACAAAAAGCTACTGTTTATATTTTTCCTCCTGCTATTCTC

>6634_6634_1_ARL8B-CLASP2_ARL8B_chr3_5164273_ENST00000256496_CLASP2_chr3_33738425_ENST00000399362_length(amino acids)=1489AA_BP=41
MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIAVSLMGLEILSAFVDRLSTRFKSYVAMVIVALIDRMGDAKDKVRDEAQTL
ILKLMDQVAPPMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFGAQPLVISKLIPHLCILFGDSNSQVRDAAILAIVEIYRHVGEKVRM
DLYKRGIPPARLEMIFAKFDEVQSSGGMILSVCKDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGGASKEGG
AGAVDEDDFIKAFTDVPSIQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQ
VVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQ
EWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESL
NRPFSSKWSTANPSTVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQSVRSGRLGAGALNAGSYASLEDTSDKLDGTASE
DGRVRAKLSAPLAGMGNAKADSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASAQKRSKIPRSQGCSREASPSRL
SVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALLLGDIRTKKKPARRRY
ESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFA
DPHGKVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVA
ILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNG
TQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSM
CGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLK
ELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDP
HKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLV

--------------------------------------------------------------
>6634_6634_2_ARL8B-CLASP2_ARL8B_chr3_5164273_ENST00000256496_CLASP2_chr3_33738425_ENST00000468888_length(transcript)=7105nt_BP=369nt
GGATTGGCCGCGCCGCTCTTGCCGTGGGTGCCGACGGCGGCGCCGGGACGGGCGTGGGGGGTAGGGCGAGTCATATGATCCGCTCGGCTT
CCTGGGTCTGGCTGCTGCCGCCCGCCGGTGTCCGCCCGTGTCGCGCCGGGGCACCAAGGAGCCGTTGGAGGGTCCGGGCGGAGGCCCGCT
CGTGTGGAAGTCGTCGACGCCGCCGCTCGTCCGTCCTCCCGTCCGTTCTCGCTCCCGGCCGCCATCATGCTGGCGCTCATCTCCCGCCTG
CTGGACTGGTTCCGTTCGCTCTTCTGGAAGGAAGAGATGGAGCTGACGCTCGTGGGGCTGCAGTACTCGGGCAAGACCACCTTCGTCAAT
GTCATCGCGGTATCATTAATGGGATTGGAAATTTTAAGTGCCTTTGTGGACAGATTATCAACACGCTTTAAATCCTATGTAGCAATGGTT
ATTGTAGCTTTAATAGACAGAATGGGAGATGCCAAAGACAAGGTTCGAGATGAAGCTCAGACTCTGATATTGAAGTTAATGGATCAAGTA
GCACCACCTATGTACATTTGGGAGCAGTTGGCTTCTGGTTTTAAACACAAGAATTTTCGATCTCGAGAAGGCGTGTGTCTGTGTCTTATT
GAAACCTTAAACATTTTTGGGGCTCAGCCACTAGTCATCAGCAAATTGATACCACATTTGTGTATCCTGTTTGGAGACTCCAACAGTCAG
GTGAGAGATGCTGCAATATTGGCTATAGTGGAGATTTATAGACATGTGGGAGAAAAAGTGAGGATGGATCTTTATAAGAGAGGAATTCCC
CCTGCTAGATTAGAAATGATATTTGCCAAATTTGATGAAGTGCAAAGTTCAGGCGGTATGATTTTGAGTGTCTGCAAAGATAAAAGCTTC
GATGATGAAGAATCAGTGGATGGAAATAGGCCATCATCAGCTGCATCAGCCTTCAAGGTTCCTGCACCTAAAACATCCGGAAATCCTGCC
AACAGTGCAAGGAAGCCTGGTTCAGCAGGTGGCCCTAAGGTTGGAGCAGGTGCTTCTAAGGAAGGAGGTGCTGGAGCAGTTGATGAAGAT
GATTTTATAAAAGCTTTTACAGATGTCCCTTCTATTCAGATTTATTCTAGTCGAGAACTCGAAGAAACATTAAATAAAATCAGGGAAATT
TTGTCAGATGATAAACATGACTGGGATCAGCGTGCCAATGCACTGAAGAAAATTCGATCACTGCTTGTTGCTGGAGCTGCACAGTATGAT
TGCTTTTTTCAACATTTACGATTGTTGGATGGAGCACTTAAACTTTCAGCTAAGGATCTTAGATCCCAGGTGGTTAGAGAAGCTTGTATT
ACTGTAGCCCACCTTTCAACAGTTTTGGGAAACAAGTTTGATCATGGCGCTGAAGCCATTGTACCTACACTTTTTAATCTCGTCCCCAAT
AGTGCAAAAGTCATGGCAACTTCTGGATGTGCAGCAATCAGATTTATCATTCGGCATACTCATGTACCCAGACTTATACCTTTAATAACA
AGCAATTGCACATCAAAATCAGTTCCCGTGAGGAGACGTTCATTTGAATTTTTAGATTTATTGTTGCAAGAGTGGCAGACTCATTCATTG
GAAAGACATGCAGCCGTCTTGGTTGAAACTATTAAAAAGGGAATTCATGATGCTGACGCTGAGGCCAGAGTGGAGGCAAGAAAGACATAC
ATGGGTCTTAGAAACCACTTTCCTGGTGAAGCTGAAACATTATATAATTCCCTTGAGCCATCTTATCAGAAGAGTCTTCAAACTTACTTA
AAGAGTTCTGGCAGTGTAGCATCTCTTCCACAATCAGACAGGTCCTCATCCAGCTCACAGGAAAGTCTCAATCGCCCTTTTTCTTCCAAA
TGGTCTACAGCAAATCCATCAACTGTGGCTGGAAGAGTATCAGCAGGCAGCAGCAAAGCCAGTTCCCTTCCAGGAAGCCTGCAGCGTTCA
CGAAGTGACATTGATGTGAATGCTGCTGCAGGTGCCAAGGCACATCATGCTGCTGGACAGTCTGTGCGAAGCGGGCGCTTAGGTGCAGGT
GCCCTGAATGCAGGTTCCTATGCGTCACTAGAGGATACTTCTGACAAGCTGGATGGAACAGCATCTGAAGATGGCCGGGTGAGAGCAAAA
CTTTCAGCACCACTTGCTGGCATGGGAAATGCCAAGGCAGATTCTAGAGGAAGAAGTCGAACAAAAATGGTGTCTCAATCACAGCCTGGT
AGCCGGTCTGGGTCTCCAGGAAGAGTTCTGACCACAACAGCCCTGTCCACTGTGAGCTCTGGTGTTCAAAGAGTCCTGGTCAATTCAGCC
TCAGCACAAAAAAGAAGCAAGATACCACGGAGCCAGGGCTGTAGCAGAGAGGCTAGTCCATCTAGGCTTTCAGTGGCCCGAAGCAGTCGT
ATTCCTCGACCAAGTGTGAGTCAAGGATGCAGCCGGGAAGCTAGTCGGGAGAGCAGCAGAGACACAAGTCCTGTTCGCTCTTTTCAGCCC
CTCGGTCCAGGTTATGGGATCAGCCAATCAAGTCGACTGTCGTCTTCTGTTAGTGCCATGCGAGTCCTGAACACAGGTTCTGATGTGGAG
GAGGCGGTGGCAGATGCCTTGCTCTTAGGAGACATACGGACTAAGAAAAAACCAGCTCGAAGAAGATATGAATCATATGGAATGCATTCA
GATGATGACGCCAACAGCGATGCATCTAGTGCTTGTTCAGAACGCTCCTATAGTTCTCGAAATGGTAGTATTCCTACATATATGAGGCAG
ACGGAAGATGTGGCAGAAGTCCTCAATAGATGTGCTAGTTCCAATTGGTCAGAAAGGAAAGAAGGCCTCCTAGGTCTGCAGAACTTATTA
AAAAATCAGAGAACACTAAGTCGAGTTGAACTGAAAAGATTATGTGAAATTTTCACAAGAATGTTTGCTGACCCTCATGGCAAGGTATTC
AGCATGTTTTTGGAGACTCTAGTGGATTTCATACAAGTCCACAAAGATGATCTTCAAGATTGGTTGTTTGTACTGCTGACACAACTACTA
AAAAAAATGGGTGCTGATTTGCTTGGATCTGTTCAGGCAAAAGTTCAGAAAGCCCTTGATGTTACAAGAGAGTCTTTTCCAAATGATCTT
CAGTTCAATATTCTAATGAGATTTACAGTTGATCAGACCCAGACACCAAGCTTAAAGGTGAAGGTTGCTATCCTTAAATACATAGAAACT
CTGGCCAAACAGATGGATCCAGGAGATTTTATAAATTCCAGTGAAACTCGCCTAGCAGTGTCTCGGGTCATCACTTGGACAACAGAACCC
AAAAGTTCTGATGTTCGGAAGGCAGCACAGTCAGTGCTGATTTCATTATTTGAACTCAATACCCCAGAGTTTACAATGTTATTAGGAGCT
TTACCAAAAACTTTTCAGGATGGTGCTACCAAGCTTCTTCATAATCACCTTCGAAACACTGGCAATGGAACCCAGAGTTCCATGGGGAGT
CCTTTGACAAGACCAACACCACGATCACCAGCTAACTGGTCCAGTCCTCTTACTTCTCCTACCAATACATCACAGAATACTTTATCTCCA
AGTGCATTTGATTATGACACAGAAAATATGAACTCTGAAGATATTTATAGCTCTCTTAGAGGTGTCACTGAAGCAATCCAGAATTTCAGC
TTCCGTAGCCAAGAAGATATGAATGAGCCATTGAAAAGGGATTCTAAAAAAGATGATGGCGATTCAATGTGTGGTGGTCCTGGGATGTCT
GACCCAAGAGCAGGAGGTGATGCTACTGACTCAAGTCAAACAGCTCTTGATAATAAAGCTTCATTGCTCCATTCAATGCCTACTCACTCC
TCTCCACGCTCTCGAGACTATAATCCATATAACTATTCAGATAGCATCAGTCCCTTCAACAAGTCTGCCCTCAAGGAAGCCATGTTTGAT
GATGATGCTGACCAGTTTCCTGACGATCTTTCCCTAGATCATTCTGACCTAGTTGCAGAGTTGTTGAAGGAGCTGTCTAACCATAATGAG
CGTGTAGAAGAAAGAAAAATTGCCCTCTATGAACTTATGAAACTGACACAGGAAGAATCTTTTAGTGTTTGGGATGAACACTTCAAAACA
ATATTGCTTTTATTGCTTGAAACGCTTGGAGATAAAGAGCCTACAATCAGGGCTTTGGCATTAAAGGTTTTAAGAGAAATCCTAAGGCAT
CAACCAGCAAGATTTAAAAACTATGCAGAATTGACTGTCATGAAAACATTGGAAGCACATAAAGATCCTCATAAGGAGGTGGTGAGATCT
GCTGAGGAAGCGGCATCAGTGTTGGCCACTTCAATTAGTCCAGAGCAGTGCATCAAAGTGCTTTGTCCTATCATTCAAACTGCAGACTAC
CCAATTAATCTGGCTGCAATCAAAATGCAAACAAAAGTGATAGAGAGAGTGTCCAAGGAAACCCTAAACCTGCTTTTGCCAGAGATTATG
CCAGGTCTAATACAGGGTTATGATAATTCAGAGAGCAGTGTTCGGAAAGCTTGTGTCTTCTGCCTGGTGGCTGTTCATGCGGTAATTGGT
GATGAACTAAAACCACATCTCAGTCAACTTACTGGCAGTAAAATGAAGCTACTGAATCTTTACATCAAACGTGCACAAACAGGTTCTGGA
GGAGCTGATCCCACTACTGATGTTTCTGGACAAAGTTAGTGAAGCTCATCACAGCGAACCAGGTCTCTCAAAAGAAAGGACAGATAGACC
ACCCTCATCAATGAAAGGAAGTTCTCAAACACATCCTTTGGAACTTACTATTGTTTCCCAGTTTTAGTTTTTTGTTTCGTTTCGTTTTGT
ATTTTCTGTAACAGAGGACTATCCTCAGTCTGCATGTAACTTTTATGATAGTTATTCCAAATTCAAGAAGAAGCAGTATTAACATCAATT
GATCGACACAAAGTAATTTTTAATTTAATTCATCATTTCACATGTTTGTACTTTGTCTTCCCATTAACCTTTGCCAGTGTTATGATTGTA
TAAATTTTTTTAAATGCTGGTTAAACAGGAATGCTTAAAGCTTTAAAAGTTTAACAGTCTAAAACATTTTTGCTTTTATTCAACTGCAGA
ATAATATTTTTATTGCTACTTTGAGTTTTGTTTCGTATCATGTCCTATGCTAGAAATATTTAAATGATGTGAAACAAAGCAGGACTAATT
TGAACTACAGCTGGACTCCGTTTGTGTGATGGTGATACATGTCATTAGTTGCAACTTCTTTGGGGTGATCTATAGTTTGAAAACTAAAAC
CTCAAAGACAGATGTTACAGAATCAGCCAGTTCTGTAAAACTGATATTGTCTATTGGTTATTGATCTTGCCATCTTTATTTAAAACCATG
TCCCTTCTATGATCCCTTAAGAAAGCTGCACCAAATCATCTGCCTGTTTTTTCTTGATACTTACTGAAATAGAAGGTTTTATTGCAGGGT
TTATTTTGGTTTGTTTATATCTTTGTTGTGAATGATGCTTTTTTGTATTTATTAATATCAAATTCACTTATGAATAAACTTGATAATGGA
AACGGACAAAAAAAATCAAGTGCGTGTGTGTCCTTGACCGTCTTCTGTTTCTCACGTAATAAACAAATTATCGAGACATGGGAGTGACCA
GCACCTTTTCTTTAAATGGTGGAACCTGGTTTCCTTTTACCATGAAATTGTCTTACTTGAAAATATTGATCCTGATGAGAGAGAAGATGG
TGCCAAGGCTGTCTTTGTATAATGGGCTCAAATTCTCTACCTCTTCAGGGCTAATACTTTTAACTGAGCTGCTGCCTATAGTGTCTTTTG
GAAAACTACTTAAAGGGTGATTTTCTGTTACTTTTTAGCAAATTTTTTTAATCACCTCTTGCTACACCCATTCTTTTCATGTGCAGCCGA
CTCAAAAATTACCAGTTTTGGTGAAAGGCTAAATTAGATAATTTGGAACCAGGATACTAATGATTTCTCATCTTTACTTTTTTTTAATCC
TAATATAAAGTGAATTTGATTGAAAAGGCAAATAGCTATTAGGGAAGCAGTTTGCCATTGTTGCAGAGTTATCTGTACTTTGTTTAACTG
AAAAAAATGTAGAAATATATGTAAAGAATTTAAGACAAGAGTACTGAATGGATGATTTGTCATAGGCTTTCCCCTTTCTTTCTGTTCTAG
CAGCAGGAAAAGTTTCTCTATATCCTCTCCCTCTACCTGTAACAATTTTGTTTTCTACTGTTAATTACATTGTGTATTTATAGTTCTATG
CTTACTGTTGTGCATATACTGGCAATAAAACTGTACATAACATTACTTGAAAAAGTTAATAATGTATATCAGTTTTTCTGTCTCACTGTG
TAACAAGTCACTCAGTTTTATTTTAACTTTAGACGGTCTTGTATCAGTGGTGGTCTCTTGAATTTTGTAAGTTCATCTGAGGAGAAAAGA
TTTTTCAGGTGTAGCTACCACAATCAAAGGTATATAGCTACATACGCATGTATATATTACAGCTTATCTGTAAGAAGAAAATGCATTTTA
AACACAACTCTTCTCAGTAGCATTTTATGACCTTTGGATATGTTTGTAATCATTTCGAATCAAAATATTGATTTAATTTTGACCTCTGGT
TTAAGATACTGCTTTAACTACTGTTGACAACCAAGTAGAGTGACTTAAGCTGAACAGTAACTAACTGGAAAATTAGATAAGCACCTGGCA
TCTAATGGCAGGCAGGCACTCAAGAAATGAATTAACTACATAATGGAAAAGTATGGTTTAATGTGTCCAAATGAAAGCTAGTAGATGTAA
ACATGGAAAAATTGTGTTTACAATTTTATAATCTCAGTTGATAAGACTATAAGAAAGCTGATTATTTAAATCACTATATACAATACACCC
TTAATTTGTTCATTCCAGAAACATACTGAGATGTCAGCTACTTAAAAATGGTCACAAAAAGCTACTGTTTATATTTTTCCTCCTGCTATT

>6634_6634_2_ARL8B-CLASP2_ARL8B_chr3_5164273_ENST00000256496_CLASP2_chr3_33738425_ENST00000468888_length(amino acids)=1490AA_BP=41
MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIAVSLMGLEILSAFVDRLSTRFKSYVAMVIVALIDRMGDAKDKVRDEAQTL
ILKLMDQVAPPMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFGAQPLVISKLIPHLCILFGDSNSQVRDAAILAIVEIYRHVGEKVRM
DLYKRGIPPARLEMIFAKFDEVQSSGGMILSVCKDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGAGASKEG
GAGAVDEDDFIKAFTDVPSIQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRS
QVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLL
QEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQES
LNRPFSSKWSTANPSTVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQSVRSGRLGAGALNAGSYASLEDTSDKLDGTAS
EDGRVRAKLSAPLAGMGNAKADSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASAQKRSKIPRSQGCSREASPSR
LSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALLLGDIRTKKKPARRR
YESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMF
ADPHGKVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKV
AILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGN
GTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDS
MCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELL
KELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKD
PHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCL

--------------------------------------------------------------
>6634_6634_3_ARL8B-CLASP2_ARL8B_chr3_5164273_ENST00000419534_CLASP2_chr3_33738425_ENST00000399362_length(transcript)=7026nt_BP=293nt
GATCCGCTCGGCTTCCTGGGTCTGGCTGCTGCCGCCCGCCGGTGTCCGCCCGTGTCGCGCCGGGGCACCAAGGAGCCGTTGGAGGGTCCG
GGCGGAGGCCCGCTCGTGTGGAAGTCGTCGACGCCGCCGCTCGTCCGTCCTCCCGTCCGTTCTCGCTCCCGGCCGCCATCATGCTGGCGC
TCATCTCCCGCCTGCTGGACTGGTTCCGTTCGCTCTTCTGGAAGGAAGAGATGGAGCTGACGCTCGTGGGGCTGCAGTACTCGGGCAAGA
CCACCTTCGTCAATGTCATCGCGGTATCATTAATGGGATTGGAAATTTTAAGTGCCTTTGTGGACAGATTATCAACACGCTTTAAATCCT
ATGTAGCAATGGTTATTGTAGCTTTAATAGACAGAATGGGAGATGCCAAAGACAAGGTTCGAGATGAAGCTCAGACTCTGATATTGAAGT
TAATGGATCAAGTAGCACCACCTATGTACATTTGGGAGCAGTTGGCTTCTGGTTTTAAACACAAGAATTTTCGATCTCGAGAAGGCGTGT
GTCTGTGTCTTATTGAAACCTTAAACATTTTTGGGGCTCAGCCACTAGTCATCAGCAAATTGATACCACATTTGTGTATCCTGTTTGGAG
ACTCCAACAGTCAGGTGAGAGATGCTGCAATATTGGCTATAGTGGAGATTTATAGACATGTGGGAGAAAAAGTGAGGATGGATCTTTATA
AGAGAGGAATTCCCCCTGCTAGATTAGAAATGATATTTGCCAAATTTGATGAAGTGCAAAGTTCAGGCGGTATGATTTTGAGTGTCTGCA
AAGATAAAAGCTTCGATGATGAAGAATCAGTGGATGGAAATAGGCCATCATCAGCTGCATCAGCCTTCAAGGTTCCTGCACCTAAAACAT
CCGGAAATCCTGCCAACAGTGCAAGGAAGCCTGGTTCAGCAGGTGGCCCTAAGGTTGGAGGTGCTTCTAAGGAAGGAGGTGCTGGAGCAG
TTGATGAAGATGATTTTATAAAAGCTTTTACAGATGTCCCTTCTATTCAGATTTATTCTAGTCGAGAACTCGAAGAAACATTAAATAAAA
TCAGGGAAATTTTGTCAGATGATAAACATGACTGGGATCAGCGTGCCAATGCACTGAAGAAAATTCGATCACTGCTTGTTGCTGGAGCTG
CACAGTATGATTGCTTTTTTCAACATTTACGATTGTTGGATGGAGCACTTAAACTTTCAGCTAAGGATCTTAGATCCCAGGTGGTTAGAG
AAGCTTGTATTACTGTAGCCCACCTTTCAACAGTTTTGGGAAACAAGTTTGATCATGGCGCTGAAGCCATTGTACCTACACTTTTTAATC
TCGTCCCCAATAGTGCAAAAGTCATGGCAACTTCTGGATGTGCAGCAATCAGATTTATCATTCGGCATACTCATGTACCCAGACTTATAC
CTTTAATAACAAGCAATTGCACATCAAAATCAGTTCCCGTGAGGAGACGTTCATTTGAATTTTTAGATTTATTGTTGCAAGAGTGGCAGA
CTCATTCATTGGAAAGACATGCAGCCGTCTTGGTTGAAACTATTAAAAAGGGAATTCATGATGCTGACGCTGAGGCCAGAGTGGAGGCAA
GAAAGACATACATGGGTCTTAGAAACCACTTTCCTGGTGAAGCTGAAACATTATATAATTCCCTTGAGCCATCTTATCAGAAGAGTCTTC
AAACTTACTTAAAGAGTTCTGGCAGTGTAGCATCTCTTCCACAATCAGACAGGTCCTCATCCAGCTCACAGGAAAGTCTCAATCGCCCTT
TTTCTTCCAAATGGTCTACAGCAAATCCATCAACTGTGGCTGGAAGAGTATCAGCAGGCAGCAGCAAAGCCAGTTCCCTTCCAGGAAGCC
TGCAGCGTTCACGAAGTGACATTGATGTGAATGCTGCTGCAGGTGCCAAGGCACATCATGCTGCTGGACAGTCTGTGCGAAGCGGGCGCT
TAGGTGCAGGTGCCCTGAATGCAGGTTCCTATGCGTCACTAGAGGATACTTCTGACAAGCTGGATGGAACAGCATCTGAAGATGGCCGGG
TGAGAGCAAAACTTTCAGCACCACTTGCTGGCATGGGAAATGCCAAGGCAGATTCTAGAGGAAGAAGTCGAACAAAAATGGTGTCTCAAT
CACAGCCTGGTAGCCGGTCTGGGTCTCCAGGAAGAGTTCTGACCACAACAGCCCTGTCCACTGTGAGCTCTGGTGTTCAAAGAGTCCTGG
TCAATTCAGCCTCAGCACAAAAAAGAAGCAAGATACCACGGAGCCAGGGCTGTAGCAGAGAGGCTAGTCCATCTAGGCTTTCAGTGGCCC
GAAGCAGTCGTATTCCTCGACCAAGTGTGAGTCAAGGATGCAGCCGGGAAGCTAGTCGGGAGAGCAGCAGAGACACAAGTCCTGTTCGCT
CTTTTCAGCCCCTCGGTCCAGGTTATGGGATCAGCCAATCAAGTCGACTGTCGTCTTCTGTTAGTGCCATGCGAGTCCTGAACACAGGTT
CTGATGTGGAGGAGGCGGTGGCAGATGCCTTGCTCTTAGGAGACATACGGACTAAGAAAAAACCAGCTCGAAGAAGATATGAATCATATG
GAATGCATTCAGATGATGACGCCAACAGCGATGCATCTAGTGCTTGTTCAGAACGCTCCTATAGTTCTCGAAATGGTAGTATTCCTACAT
ATATGAGGCAGACGGAAGATGTGGCAGAAGTCCTCAATAGATGTGCTAGTTCCAATTGGTCAGAAAGGAAAGAAGGCCTCCTAGGTCTGC
AGAACTTATTAAAAAATCAGAGAACACTAAGTCGAGTTGAACTGAAAAGATTATGTGAAATTTTCACAAGAATGTTTGCTGACCCTCATG
GCAAGGTATTCAGCATGTTTTTGGAGACTCTAGTGGATTTCATACAAGTCCACAAAGATGATCTTCAAGATTGGTTGTTTGTACTGCTGA
CACAACTACTAAAAAAAATGGGTGCTGATTTGCTTGGATCTGTTCAGGCAAAAGTTCAGAAAGCCCTTGATGTTACAAGAGAGTCTTTTC
CAAATGATCTTCAGTTCAATATTCTAATGAGATTTACAGTTGATCAGACCCAGACACCAAGCTTAAAGGTGAAGGTTGCTATCCTTAAAT
ACATAGAAACTCTGGCCAAACAGATGGATCCAGGAGATTTTATAAATTCCAGTGAAACTCGCCTAGCAGTGTCTCGGGTCATCACTTGGA
CAACAGAACCCAAAAGTTCTGATGTTCGGAAGGCAGCACAGTCAGTGCTGATTTCATTATTTGAACTCAATACCCCAGAGTTTACAATGT
TATTAGGAGCTTTACCAAAAACTTTTCAGGATGGTGCTACCAAGCTTCTTCATAATCACCTTCGAAACACTGGCAATGGAACCCAGAGTT
CCATGGGGAGTCCTTTGACAAGACCAACACCACGATCACCAGCTAACTGGTCCAGTCCTCTTACTTCTCCTACCAATACATCACAGAATA
CTTTATCTCCAAGTGCATTTGATTATGACACAGAAAATATGAACTCTGAAGATATTTATAGCTCTCTTAGAGGTGTCACTGAAGCAATCC
AGAATTTCAGCTTCCGTAGCCAAGAAGATATGAATGAGCCATTGAAAAGGGATTCTAAAAAAGATGATGGCGATTCAATGTGTGGTGGTC
CTGGGATGTCTGACCCAAGAGCAGGAGGTGATGCTACTGACTCAAGTCAAACAGCTCTTGATAATAAAGCTTCATTGCTCCATTCAATGC
CTACTCACTCCTCTCCACGCTCTCGAGACTATAATCCATATAACTATTCAGATAGCATCAGTCCCTTCAACAAGTCTGCCCTCAAGGAAG
CCATGTTTGATGATGATGCTGACCAGTTTCCTGACGATCTTTCCCTAGATCATTCTGACCTAGTTGCAGAGTTGTTGAAGGAGCTGTCTA
ACCATAATGAGCGTGTAGAAGAAAGAAAAATTGCCCTCTATGAACTTATGAAACTGACACAGGAAGAATCTTTTAGTGTTTGGGATGAAC
ACTTCAAAACAATATTGCTTTTATTGCTTGAAACGCTTGGAGATAAAGAGCCTACAATCAGGGCTTTGGCATTAAAGGTTTTAAGAGAAA
TCCTAAGGCATCAACCAGCAAGATTTAAAAACTATGCAGAATTGACTGTCATGAAAACATTGGAAGCACATAAAGATCCTCATAAGGAGG
TGGTGAGATCTGCTGAGGAAGCGGCATCAGTGTTGGCCACTTCAATTAGTCCAGAGCAGTGCATCAAAGTGCTTTGTCCTATCATTCAAA
CTGCAGACTACCCAATTAATCTGGCTGCAATCAAAATGCAAACAAAAGTGATAGAGAGAGTGTCCAAGGAAACCCTAAACCTGCTTTTGC
CAGAGATTATGCCAGGTCTAATACAGGGTTATGATAATTCAGAGAGCAGTGTTCGGAAAGCTTGTGTCTTCTGCCTGGTGGCTGTTCATG
CGGTAATTGGTGATGAACTAAAACCACATCTCAGTCAACTTACTGGCAGTAAAATGAAGCTACTGAATCTTTACATCAAACGTGCACAAA
CAGGTTCTGGAGGAGCTGATCCCACTACTGATGTTTCTGGACAAAGTTAGTGAAGCTCATCACAGCGAACCAGGTCTCTCAAAAGAAAGG
ACAGATAGACCACCCTCATCAATGAAAGGAAGTTCTCAAACACATCCTTTGGAACTTACTATTGTTTCCCAGTTTTAGTTTTTTGTTTCG
TTTCGTTTTGTATTTTCTGTAACAGAGGACTATCCTCAGTCTGCATGTAACTTTTATGATAGTTATTCCAAATTCAAGAAGAAGCAGTAT
TAACATCAATTGATCGACACAAAGTAATTTTTAATTTAATTCATCATTTCACATGTTTGTACTTTGTCTTCCCATTAACCTTTGCCAGTG
TTATGATTGTATAAATTTTTTTAAATGCTGGTTAAACAGGAATGCTTAAAGCTTTAAAAGTTTAACAGTCTAAAACATTTTTGCTTTTAT
TCAACTGCAGAATAATATTTTTATTGCTACTTTGAGTTTTGTTTCGTATCATGTCCTATGCTAGAAATATTTAAATGATGTGAAACAAAG
CAGGACTAATTTGAACTACAGCTGGACTCCGTTTGTGTGATGGTGATACATGTCATTAGTTGCAACTTCTTTGGGGTGATCTATAGTTTG
AAAACTAAAACCTCAAAGACAGATGTTACAGAATCAGCCAGTTCTGTAAAACTGATATTGTCTATTGGTTATTGATCTTGCCATCTTTAT
TTAAAACCATGTCCCTTCTATGATCCCTTAAGAAAGCTGCACCAAATCATCTGCCTGTTTTTTCTTGATACTTACTGAAATAGAAGGTTT
TATTGCAGGGTTTATTTTGGTTTGTTTATATCTTTGTTGTGAATGATGCTTTTTTGTATTTATTAATATCAAATTCACTTATGAATAAAC
TTGATAATGGAAACGGACAAAAAAAATCAAGTGCGTGTGTGTCCTTGACCGTCTTCTGTTTCTCACGTAATAAACAAATTATCGAGACAT
GGGAGTGACCAGCACCTTTTCTTTAAATGGTGGAACCTGGTTTCCTTTTACCATGAAATTGTCTTACTTGAAAATATTGATCCTGATGAG
AGAGAAGATGGTGCCAAGGCTGTCTTTGTATAATGGGCTCAAATTCTCTACCTCTTCAGGGCTAATACTTTTAACTGAGCTGCTGCCTAT
AGTGTCTTTTGGAAAACTACTTAAAGGGTGATTTTCTGTTACTTTTTAGCAAATTTTTTTAATCACCTCTTGCTACACCCATTCTTTTCA
TGTGCAGCCGACTCAAAAATTACCAGTTTTGGTGAAAGGCTAAATTAGATAATTTGGAACCAGGATACTAATGATTTCTCATCTTTACTT
TTTTTTAATCCTAATATAAAGTGAATTTGATTGAAAAGGCAAATAGCTATTAGGGAAGCAGTTTGCCATTGTTGCAGAGTTATCTGTACT
TTGTTTAACTGAAAAAAATGTAGAAATATATGTAAAGAATTTAAGACAAGAGTACTGAATGGATGATTTGTCATAGGCTTTCCCCTTTCT
TTCTGTTCTAGCAGCAGGAAAAGTTTCTCTATATCCTCTCCCTCTACCTGTAACAATTTTGTTTTCTACTGTTAATTACATTGTGTATTT
ATAGTTCTATGCTTACTGTTGTGCATATACTGGCAATAAAACTGTACATAACATTACTTGAAAAAGTTAATAATGTATATCAGTTTTTCT
GTCTCACTGTGTAACAAGTCACTCAGTTTTATTTTAACTTTAGACGGTCTTGTATCAGTGGTGGTCTCTTGAATTTTGTAAGTTCATCTG
AGGAGAAAAGATTTTTCAGGTGTAGCTACCACAATCAAAGGTATATAGCTACATACGCATGTATATATTACAGCTTATCTGTAAGAAGAA
AATGCATTTTAAACACAACTCTTCTCAGTAGCATTTTATGACCTTTGGATATGTTTGTAATCATTTCGAATCAAAATATTGATTTAATTT
TGACCTCTGGTTTAAGATACTGCTTTAACTACTGTTGACAACCAAGTAGAGTGACTTAAGCTGAACAGTAACTAACTGGAAAATTAGATA
AGCACCTGGCATCTAATGGCAGGCAGGCACTCAAGAAATGAATTAACTACATAATGGAAAAGTATGGTTTAATGTGTCCAAATGAAAGCT
AGTAGATGTAAACATGGAAAAATTGTGTTTACAATTTTATAATCTCAGTTGATAAGACTATAAGAAAGCTGATTATTTAAATCACTATAT
ACAATACACCCTTAATTTGTTCATTCCAGAAACATACTGAGATGTCAGCTACTTAAAAATGGTCACAAAAAGCTACTGTTTATATTTTTC
CTCCTGCTATTCTCTCCCAAATTAATTATTAATAAGTGTTGTTCATTTACTGCACTGCTGAGAACTAATTAAAATTATATATTCCAGATT

>6634_6634_3_ARL8B-CLASP2_ARL8B_chr3_5164273_ENST00000419534_CLASP2_chr3_33738425_ENST00000399362_length(amino acids)=1489AA_BP=41
MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIAVSLMGLEILSAFVDRLSTRFKSYVAMVIVALIDRMGDAKDKVRDEAQTL
ILKLMDQVAPPMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFGAQPLVISKLIPHLCILFGDSNSQVRDAAILAIVEIYRHVGEKVRM
DLYKRGIPPARLEMIFAKFDEVQSSGGMILSVCKDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGGASKEGG
AGAVDEDDFIKAFTDVPSIQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQ
VVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQ
EWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESL
NRPFSSKWSTANPSTVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQSVRSGRLGAGALNAGSYASLEDTSDKLDGTASE
DGRVRAKLSAPLAGMGNAKADSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASAQKRSKIPRSQGCSREASPSRL
SVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALLLGDIRTKKKPARRRY
ESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFA
DPHGKVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVA
ILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNG
TQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSM
CGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLK
ELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDP
HKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLV

--------------------------------------------------------------
>6634_6634_4_ARL8B-CLASP2_ARL8B_chr3_5164273_ENST00000419534_CLASP2_chr3_33738425_ENST00000468888_length(transcript)=7029nt_BP=293nt
GATCCGCTCGGCTTCCTGGGTCTGGCTGCTGCCGCCCGCCGGTGTCCGCCCGTGTCGCGCCGGGGCACCAAGGAGCCGTTGGAGGGTCCG
GGCGGAGGCCCGCTCGTGTGGAAGTCGTCGACGCCGCCGCTCGTCCGTCCTCCCGTCCGTTCTCGCTCCCGGCCGCCATCATGCTGGCGC
TCATCTCCCGCCTGCTGGACTGGTTCCGTTCGCTCTTCTGGAAGGAAGAGATGGAGCTGACGCTCGTGGGGCTGCAGTACTCGGGCAAGA
CCACCTTCGTCAATGTCATCGCGGTATCATTAATGGGATTGGAAATTTTAAGTGCCTTTGTGGACAGATTATCAACACGCTTTAAATCCT
ATGTAGCAATGGTTATTGTAGCTTTAATAGACAGAATGGGAGATGCCAAAGACAAGGTTCGAGATGAAGCTCAGACTCTGATATTGAAGT
TAATGGATCAAGTAGCACCACCTATGTACATTTGGGAGCAGTTGGCTTCTGGTTTTAAACACAAGAATTTTCGATCTCGAGAAGGCGTGT
GTCTGTGTCTTATTGAAACCTTAAACATTTTTGGGGCTCAGCCACTAGTCATCAGCAAATTGATACCACATTTGTGTATCCTGTTTGGAG
ACTCCAACAGTCAGGTGAGAGATGCTGCAATATTGGCTATAGTGGAGATTTATAGACATGTGGGAGAAAAAGTGAGGATGGATCTTTATA
AGAGAGGAATTCCCCCTGCTAGATTAGAAATGATATTTGCCAAATTTGATGAAGTGCAAAGTTCAGGCGGTATGATTTTGAGTGTCTGCA
AAGATAAAAGCTTCGATGATGAAGAATCAGTGGATGGAAATAGGCCATCATCAGCTGCATCAGCCTTCAAGGTTCCTGCACCTAAAACAT
CCGGAAATCCTGCCAACAGTGCAAGGAAGCCTGGTTCAGCAGGTGGCCCTAAGGTTGGAGCAGGTGCTTCTAAGGAAGGAGGTGCTGGAG
CAGTTGATGAAGATGATTTTATAAAAGCTTTTACAGATGTCCCTTCTATTCAGATTTATTCTAGTCGAGAACTCGAAGAAACATTAAATA
AAATCAGGGAAATTTTGTCAGATGATAAACATGACTGGGATCAGCGTGCCAATGCACTGAAGAAAATTCGATCACTGCTTGTTGCTGGAG
CTGCACAGTATGATTGCTTTTTTCAACATTTACGATTGTTGGATGGAGCACTTAAACTTTCAGCTAAGGATCTTAGATCCCAGGTGGTTA
GAGAAGCTTGTATTACTGTAGCCCACCTTTCAACAGTTTTGGGAAACAAGTTTGATCATGGCGCTGAAGCCATTGTACCTACACTTTTTA
ATCTCGTCCCCAATAGTGCAAAAGTCATGGCAACTTCTGGATGTGCAGCAATCAGATTTATCATTCGGCATACTCATGTACCCAGACTTA
TACCTTTAATAACAAGCAATTGCACATCAAAATCAGTTCCCGTGAGGAGACGTTCATTTGAATTTTTAGATTTATTGTTGCAAGAGTGGC
AGACTCATTCATTGGAAAGACATGCAGCCGTCTTGGTTGAAACTATTAAAAAGGGAATTCATGATGCTGACGCTGAGGCCAGAGTGGAGG
CAAGAAAGACATACATGGGTCTTAGAAACCACTTTCCTGGTGAAGCTGAAACATTATATAATTCCCTTGAGCCATCTTATCAGAAGAGTC
TTCAAACTTACTTAAAGAGTTCTGGCAGTGTAGCATCTCTTCCACAATCAGACAGGTCCTCATCCAGCTCACAGGAAAGTCTCAATCGCC
CTTTTTCTTCCAAATGGTCTACAGCAAATCCATCAACTGTGGCTGGAAGAGTATCAGCAGGCAGCAGCAAAGCCAGTTCCCTTCCAGGAA
GCCTGCAGCGTTCACGAAGTGACATTGATGTGAATGCTGCTGCAGGTGCCAAGGCACATCATGCTGCTGGACAGTCTGTGCGAAGCGGGC
GCTTAGGTGCAGGTGCCCTGAATGCAGGTTCCTATGCGTCACTAGAGGATACTTCTGACAAGCTGGATGGAACAGCATCTGAAGATGGCC
GGGTGAGAGCAAAACTTTCAGCACCACTTGCTGGCATGGGAAATGCCAAGGCAGATTCTAGAGGAAGAAGTCGAACAAAAATGGTGTCTC
AATCACAGCCTGGTAGCCGGTCTGGGTCTCCAGGAAGAGTTCTGACCACAACAGCCCTGTCCACTGTGAGCTCTGGTGTTCAAAGAGTCC
TGGTCAATTCAGCCTCAGCACAAAAAAGAAGCAAGATACCACGGAGCCAGGGCTGTAGCAGAGAGGCTAGTCCATCTAGGCTTTCAGTGG
CCCGAAGCAGTCGTATTCCTCGACCAAGTGTGAGTCAAGGATGCAGCCGGGAAGCTAGTCGGGAGAGCAGCAGAGACACAAGTCCTGTTC
GCTCTTTTCAGCCCCTCGGTCCAGGTTATGGGATCAGCCAATCAAGTCGACTGTCGTCTTCTGTTAGTGCCATGCGAGTCCTGAACACAG
GTTCTGATGTGGAGGAGGCGGTGGCAGATGCCTTGCTCTTAGGAGACATACGGACTAAGAAAAAACCAGCTCGAAGAAGATATGAATCAT
ATGGAATGCATTCAGATGATGACGCCAACAGCGATGCATCTAGTGCTTGTTCAGAACGCTCCTATAGTTCTCGAAATGGTAGTATTCCTA
CATATATGAGGCAGACGGAAGATGTGGCAGAAGTCCTCAATAGATGTGCTAGTTCCAATTGGTCAGAAAGGAAAGAAGGCCTCCTAGGTC
TGCAGAACTTATTAAAAAATCAGAGAACACTAAGTCGAGTTGAACTGAAAAGATTATGTGAAATTTTCACAAGAATGTTTGCTGACCCTC
ATGGCAAGGTATTCAGCATGTTTTTGGAGACTCTAGTGGATTTCATACAAGTCCACAAAGATGATCTTCAAGATTGGTTGTTTGTACTGC
TGACACAACTACTAAAAAAAATGGGTGCTGATTTGCTTGGATCTGTTCAGGCAAAAGTTCAGAAAGCCCTTGATGTTACAAGAGAGTCTT
TTCCAAATGATCTTCAGTTCAATATTCTAATGAGATTTACAGTTGATCAGACCCAGACACCAAGCTTAAAGGTGAAGGTTGCTATCCTTA
AATACATAGAAACTCTGGCCAAACAGATGGATCCAGGAGATTTTATAAATTCCAGTGAAACTCGCCTAGCAGTGTCTCGGGTCATCACTT
GGACAACAGAACCCAAAAGTTCTGATGTTCGGAAGGCAGCACAGTCAGTGCTGATTTCATTATTTGAACTCAATACCCCAGAGTTTACAA
TGTTATTAGGAGCTTTACCAAAAACTTTTCAGGATGGTGCTACCAAGCTTCTTCATAATCACCTTCGAAACACTGGCAATGGAACCCAGA
GTTCCATGGGGAGTCCTTTGACAAGACCAACACCACGATCACCAGCTAACTGGTCCAGTCCTCTTACTTCTCCTACCAATACATCACAGA
ATACTTTATCTCCAAGTGCATTTGATTATGACACAGAAAATATGAACTCTGAAGATATTTATAGCTCTCTTAGAGGTGTCACTGAAGCAA
TCCAGAATTTCAGCTTCCGTAGCCAAGAAGATATGAATGAGCCATTGAAAAGGGATTCTAAAAAAGATGATGGCGATTCAATGTGTGGTG
GTCCTGGGATGTCTGACCCAAGAGCAGGAGGTGATGCTACTGACTCAAGTCAAACAGCTCTTGATAATAAAGCTTCATTGCTCCATTCAA
TGCCTACTCACTCCTCTCCACGCTCTCGAGACTATAATCCATATAACTATTCAGATAGCATCAGTCCCTTCAACAAGTCTGCCCTCAAGG
AAGCCATGTTTGATGATGATGCTGACCAGTTTCCTGACGATCTTTCCCTAGATCATTCTGACCTAGTTGCAGAGTTGTTGAAGGAGCTGT
CTAACCATAATGAGCGTGTAGAAGAAAGAAAAATTGCCCTCTATGAACTTATGAAACTGACACAGGAAGAATCTTTTAGTGTTTGGGATG
AACACTTCAAAACAATATTGCTTTTATTGCTTGAAACGCTTGGAGATAAAGAGCCTACAATCAGGGCTTTGGCATTAAAGGTTTTAAGAG
AAATCCTAAGGCATCAACCAGCAAGATTTAAAAACTATGCAGAATTGACTGTCATGAAAACATTGGAAGCACATAAAGATCCTCATAAGG
AGGTGGTGAGATCTGCTGAGGAAGCGGCATCAGTGTTGGCCACTTCAATTAGTCCAGAGCAGTGCATCAAAGTGCTTTGTCCTATCATTC
AAACTGCAGACTACCCAATTAATCTGGCTGCAATCAAAATGCAAACAAAAGTGATAGAGAGAGTGTCCAAGGAAACCCTAAACCTGCTTT
TGCCAGAGATTATGCCAGGTCTAATACAGGGTTATGATAATTCAGAGAGCAGTGTTCGGAAAGCTTGTGTCTTCTGCCTGGTGGCTGTTC
ATGCGGTAATTGGTGATGAACTAAAACCACATCTCAGTCAACTTACTGGCAGTAAAATGAAGCTACTGAATCTTTACATCAAACGTGCAC
AAACAGGTTCTGGAGGAGCTGATCCCACTACTGATGTTTCTGGACAAAGTTAGTGAAGCTCATCACAGCGAACCAGGTCTCTCAAAAGAA
AGGACAGATAGACCACCCTCATCAATGAAAGGAAGTTCTCAAACACATCCTTTGGAACTTACTATTGTTTCCCAGTTTTAGTTTTTTGTT
TCGTTTCGTTTTGTATTTTCTGTAACAGAGGACTATCCTCAGTCTGCATGTAACTTTTATGATAGTTATTCCAAATTCAAGAAGAAGCAG
TATTAACATCAATTGATCGACACAAAGTAATTTTTAATTTAATTCATCATTTCACATGTTTGTACTTTGTCTTCCCATTAACCTTTGCCA
GTGTTATGATTGTATAAATTTTTTTAAATGCTGGTTAAACAGGAATGCTTAAAGCTTTAAAAGTTTAACAGTCTAAAACATTTTTGCTTT
TATTCAACTGCAGAATAATATTTTTATTGCTACTTTGAGTTTTGTTTCGTATCATGTCCTATGCTAGAAATATTTAAATGATGTGAAACA
AAGCAGGACTAATTTGAACTACAGCTGGACTCCGTTTGTGTGATGGTGATACATGTCATTAGTTGCAACTTCTTTGGGGTGATCTATAGT
TTGAAAACTAAAACCTCAAAGACAGATGTTACAGAATCAGCCAGTTCTGTAAAACTGATATTGTCTATTGGTTATTGATCTTGCCATCTT
TATTTAAAACCATGTCCCTTCTATGATCCCTTAAGAAAGCTGCACCAAATCATCTGCCTGTTTTTTCTTGATACTTACTGAAATAGAAGG
TTTTATTGCAGGGTTTATTTTGGTTTGTTTATATCTTTGTTGTGAATGATGCTTTTTTGTATTTATTAATATCAAATTCACTTATGAATA
AACTTGATAATGGAAACGGACAAAAAAAATCAAGTGCGTGTGTGTCCTTGACCGTCTTCTGTTTCTCACGTAATAAACAAATTATCGAGA
CATGGGAGTGACCAGCACCTTTTCTTTAAATGGTGGAACCTGGTTTCCTTTTACCATGAAATTGTCTTACTTGAAAATATTGATCCTGAT
GAGAGAGAAGATGGTGCCAAGGCTGTCTTTGTATAATGGGCTCAAATTCTCTACCTCTTCAGGGCTAATACTTTTAACTGAGCTGCTGCC
TATAGTGTCTTTTGGAAAACTACTTAAAGGGTGATTTTCTGTTACTTTTTAGCAAATTTTTTTAATCACCTCTTGCTACACCCATTCTTT
TCATGTGCAGCCGACTCAAAAATTACCAGTTTTGGTGAAAGGCTAAATTAGATAATTTGGAACCAGGATACTAATGATTTCTCATCTTTA
CTTTTTTTTAATCCTAATATAAAGTGAATTTGATTGAAAAGGCAAATAGCTATTAGGGAAGCAGTTTGCCATTGTTGCAGAGTTATCTGT
ACTTTGTTTAACTGAAAAAAATGTAGAAATATATGTAAAGAATTTAAGACAAGAGTACTGAATGGATGATTTGTCATAGGCTTTCCCCTT
TCTTTCTGTTCTAGCAGCAGGAAAAGTTTCTCTATATCCTCTCCCTCTACCTGTAACAATTTTGTTTTCTACTGTTAATTACATTGTGTA
TTTATAGTTCTATGCTTACTGTTGTGCATATACTGGCAATAAAACTGTACATAACATTACTTGAAAAAGTTAATAATGTATATCAGTTTT
TCTGTCTCACTGTGTAACAAGTCACTCAGTTTTATTTTAACTTTAGACGGTCTTGTATCAGTGGTGGTCTCTTGAATTTTGTAAGTTCAT
CTGAGGAGAAAAGATTTTTCAGGTGTAGCTACCACAATCAAAGGTATATAGCTACATACGCATGTATATATTACAGCTTATCTGTAAGAA
GAAAATGCATTTTAAACACAACTCTTCTCAGTAGCATTTTATGACCTTTGGATATGTTTGTAATCATTTCGAATCAAAATATTGATTTAA
TTTTGACCTCTGGTTTAAGATACTGCTTTAACTACTGTTGACAACCAAGTAGAGTGACTTAAGCTGAACAGTAACTAACTGGAAAATTAG
ATAAGCACCTGGCATCTAATGGCAGGCAGGCACTCAAGAAATGAATTAACTACATAATGGAAAAGTATGGTTTAATGTGTCCAAATGAAA
GCTAGTAGATGTAAACATGGAAAAATTGTGTTTACAATTTTATAATCTCAGTTGATAAGACTATAAGAAAGCTGATTATTTAAATCACTA
TATACAATACACCCTTAATTTGTTCATTCCAGAAACATACTGAGATGTCAGCTACTTAAAAATGGTCACAAAAAGCTACTGTTTATATTT
TTCCTCCTGCTATTCTCTCCCAAATTAATTATTAATAAGTGTTGTTCATTTACTGCACTGCTGAGAACTAATTAAAATTATATATTCCAG

>6634_6634_4_ARL8B-CLASP2_ARL8B_chr3_5164273_ENST00000419534_CLASP2_chr3_33738425_ENST00000468888_length(amino acids)=1490AA_BP=41
MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIAVSLMGLEILSAFVDRLSTRFKSYVAMVIVALIDRMGDAKDKVRDEAQTL
ILKLMDQVAPPMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFGAQPLVISKLIPHLCILFGDSNSQVRDAAILAIVEIYRHVGEKVRM
DLYKRGIPPARLEMIFAKFDEVQSSGGMILSVCKDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGAGASKEG
GAGAVDEDDFIKAFTDVPSIQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRS
QVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLL
QEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQES
LNRPFSSKWSTANPSTVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQSVRSGRLGAGALNAGSYASLEDTSDKLDGTAS
EDGRVRAKLSAPLAGMGNAKADSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASAQKRSKIPRSQGCSREASPSR
LSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALLLGDIRTKKKPARRR
YESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMF
ADPHGKVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKV
AILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGN
GTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDS
MCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELL
KELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKD
PHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARL8B-CLASP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCLASP2chr3:5164273chr3:33738425ENST00000313350013444_5800432.0microtubules%2C MAPRE1 and MAPRE3
TgeneCLASP2chr3:5164273chr3:33738425ENST00000313350013872_12940432.0RSN and localization to the Golgi and kinetochores


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARL8B-CLASP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARL8B-CLASP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource