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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABCF3-YEATS2 (FusionGDB2 ID:HG55324TG55689)

Fusion Gene Summary for ABCF3-YEATS2

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCF3-YEATS2
Fusion gene ID: hg55324tg55689
HgeneTgene
Gene symbol

ABCF3

YEATS2

Gene ID

55324

55689

Gene nameATP binding cassette subfamily F member 3YEATS domain containing 2
SynonymsEST201864FAME4
Cytomap('ABCF3')('YEATS2')

3q27.1

3q27.1

Type of geneprotein-codingprotein-coding
DescriptionATP-binding cassette sub-family F member 3ATP-binding cassette, sub-family F (GCN20), member 3YEATS domain-containing protein 2
Modification date2020032020200313
UniProtAcc

Q9NUQ8

.
Ensembl transtripts involved in fusion geneENST00000292808, ENST00000429586, 
Fusion gene scores* DoF score4 X 4 X 3=489 X 8 X 5=360
# samples 49
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCF3 [Title/Abstract] AND YEATS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCF3(183910684)-YEATS2(183493703), # samples:1
Anticipated loss of major functional domain due to fusion event.ABCF3-YEATS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCF3-YEATS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCF3-YEATS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCF3-YEATS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneYEATS2

GO:0000122

negative regulation of transcription by RNA polymerase II

18838386

TgeneYEATS2

GO:0043966

histone H3 acetylation

18838386

TgeneYEATS2

GO:0045892

negative regulation of transcription, DNA-templated

18838386


check buttonFusion gene breakpoints across ABCF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across YEATS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-JW-A5VJ-01AABCF3chr3

183910684

+YEATS2chr3

183493703

+


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Fusion Gene ORF analysis for ABCF3-YEATS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000292808ENST00000305135ABCF3chr3

183910684

+YEATS2chr3

183493703

+
In-frameENST00000429586ENST00000305135ABCF3chr3

183910684

+YEATS2chr3

183493703

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000429586ABCF3chr3183910684+ENST00000305135YEATS2chr3183493703+5878193515838351225
ENST00000292808ABCF3chr3183910684+ENST00000305135YEATS2chr3183493703+57091766736661219

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000429586ENST00000305135ABCF3chr3183910684+YEATS2chr3183493703+0.0012499020.9987501
ENST00000292808ENST00000305135ABCF3chr3183910684+YEATS2chr3183493703+0.0010529290.9989471

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Fusion Genomic Features for ABCF3-YEATS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ABCF3chr3183910684+YEATS2chr3183493702+5.14E-050.9999486
ABCF3chr3183910684+YEATS2chr3183493702+5.14E-050.9999486

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ABCF3-YEATS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:183910684/chr3:183493703)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCF3

Q9NUQ8

.
FUNCTION: Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCF3chr3:183910684chr3:183493703ENST00000292808+1821178_424577704.0DomainABC transporter 1
HgeneABCF3chr3:183910684chr3:183493703ENST00000429586+1821178_424583710.0DomainABC transporter 1
HgeneABCF3chr3:183910684chr3:183493703ENST00000292808+1821210_217577704.0Nucleotide bindingATP 1
HgeneABCF3chr3:183910684chr3:183493703ENST00000292808+1821525_532577704.0Nucleotide bindingATP 2
HgeneABCF3chr3:183910684chr3:183493703ENST00000429586+1821210_217583710.0Nucleotide bindingATP 1
HgeneABCF3chr3:183910684chr3:183493703ENST00000429586+1821525_532583710.0Nucleotide bindingATP 2
TgeneYEATS2chr3:183910684chr3:183493703ENST000003051351631794_8427891423.0Compositional biasNote=Gly-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCF3chr3:183910684chr3:183493703ENST00000292808+1821492_707577704.0DomainABC transporter 2
HgeneABCF3chr3:183910684chr3:183493703ENST00000429586+1821492_707583710.0DomainABC transporter 2
TgeneYEATS2chr3:183910684chr3:183493703ENST00000305135163147_807891423.0Coiled coilOntology_term=ECO:0000255
TgeneYEATS2chr3:183910684chr3:183493703ENST000003051351631200_3457891423.0DomainYEATS
TgeneYEATS2chr3:183910684chr3:183493703ENST000003051351631259_2617891423.0RegionHistone H3K27cr binding
TgeneYEATS2chr3:183910684chr3:183493703ENST000003051351631282_2847891423.0RegionHistone H3K27cr binding


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Fusion Gene Sequence for ABCF3-YEATS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>349_349_1_ABCF3-YEATS2_ABCF3_chr3_183910684_ENST00000292808_YEATS2_chr3_183493703_ENST00000305135_length(transcript)=5709nt_BP=1766nt
ACAGCGACTGCGCGGACGGGTTCCTGAGTGGAACATGGCGACTTGCGCCGAAATCCTGCGGAGCGAGTTCCCCGAAATTGACGGACAAGT
CTTCGACTACGTGACCGGCGTCTTGCACAGCGGCAGCGCGGACTTCGAGTCTGTGGATGACCTGGTGGAAGCTGTAGGGGAACTATTGCA
AGAGGTGTCCGGGGACAGCAAGGATGACGCGGGCATCAGGGCCGTGTGCCAGCGCATGGCTGAGCCACAAAGCCAGGGAAATAGCCAGGT
GCTACTGGACGCCCCTATCCAGTTGTCAAAGATAACGGAGAACTACGACTGTGGAACCAAACTTCCAGGACTGCTAAAGAGGGAACAGTC
CTCGACAGTGAATGCAAAGAAGTTAGAGAAGGCCGAGGCTCGACTTAAGGCAAAGCAGGAGAAGCGCTCAGAGAAGGACACGCTCAAGAC
CAGCAACCCTCTAGTCTTAGAAGAGGCATCAGCCAGCCAGGCAGGCAGCAGAAAGGAGAGTCGGTTGGAATCATCTGGCAAGAACAAATC
CTATGATGTGCGAATTGAGAACTTTGATGTGTCTTTTGGCGATAGAGTACTGCTGGCTGGAGCGGATGTGAACCTGGCATGGGGCCGCCG
TTACGGGCTGGTGGGGCGGAATGGGTTGGGGAAGACAACGTTACTGAAGATGCTGGCCACCCGGAGTCTGCGGGTTCCAGCCCACATTTC
CCTGCTGCACGTTGAGCAAGAGGTTGCTGGAGATGACACTCCTGCCCTGCAGAGTGTGCTGGAGAGTGACAGTGTGCGAGAGGATTTGCT
ACGGAGGGAGCGGGAGCTCACTGCCCAGATTGCTGCTGGCAGGGCGGAGGGCTCTGAAGCTGCAGAGCTGGCAGAAATCTATGCCAAACT
GGAGGAGATTGAGGCTGACAAGGCACCTGCCAGGGCATCAGTCATTCTCGCTGGGCTTGGCTTTACCCCTAAAATGCAGCAGCAGCCCAC
CCGGGAGTTCTCAGGTGGCTGGAGGATGAGGCTGGCCCTGGCCCGGGCCCTCTTTGCTAGGCCAGATCTTCTGCTGTTAGATGAACCTAC
AAACATGCTGGATGTCAGGGCCATCCTGTGGCTGGAGAATTACCTGCAGACGTGGCCCTCCACCATCCTAGTCGTCTCCCACGACCGCAA
CTTCTTGAATGCCATCGCCACAGACATCATCCACCTGCACAGCCAGCGGCTAGATGGTTACCGGGGAGACTTTGAGACCTTCATCAAGAG
TAAGCAGGAGCGGCTGCTCAACCAGCAGCGTGAATATGAGGCGCAGCAGCAGTATCGCCAGCACATCCAGGTTTTCATTGACCGGTTTCG
CTACAATGCCAACAGGGCCTCTCAAGTGCAGAGTAAACTCAAGATGCTGGAGAAGCTGCCTGAGCTGAAGCCTGTGGACAAGGAATCAGA
GGTCGTAATGAAGTTCCCTGATGGGTTTGAGAAGTTCTCGCCGCCAATTCTGCAGCTAGATGAGGTGGATTTCTACTACGATCCGAAGCA
CGTCATCTTCAGTCGCCTCTCTGTGTCTGCTGATCTCGAGTCTCGCATCTGTGTGGTTGGAGAGAATGGGGCTGGGAAGTCTACCATGCT
GAAGCTGCTTTTGGGGGACCTGGCACCTGTTCGGGGCATCAGACACGCTCACAGGAATCTGAAGATTGGCTATTTCAGCCAGCACCATGT
GGAGCAGCTGGACCTAAACGTCAGTGCTGTGGAACTGCTGGCACGCAAGTTTCCTGATCTCCAGTCTGGCTCAGCTGCCAGTGGTGGGAG
TGGTGCCGGAGGAGGAGGAGGAGGAGGAGGAGGAGGCGGCAGTGGCAGCGGTGGAGGCGGCAGCACAGGAGGAGGAGGAGGAACAGCAGG
AGGAGGAACTCAAAGTACTGCTGGCCCTGGAGGGATATCTCAGCACCTGACTTACACATCTTACATCCTCAAGCAAACTCCCCAGGGCAC
ATTTTTAGTTGGCCAGCCATCACCCCAGACTTCTGGAAAACAACTCACCACTGGGTCAGTGGTCCAAGGAACACTGGGAGTCAGCACATC
TTCTGCACAAGGACAACAAACGCTAAAAGTCATCTCTGGACAGAAAACCACATTGTTTACACAGGCAGCCCATGGAGGACAGGCATCTCT
AATGAAAATATCCGATAGCACCTTGAAGACTGTGCCAGCCACCTCACAGCTCTCGAAGCCTGGAACCACAATGCTGAGAGTAGCAGGAGG
GGTTATCACAACTGCCACTTCCCCTGCCGTGGCCCTCTCAGCAAACGGTCCTGCACAACAGTCTGAAGGAATGGCTCCCGTGTCTTCATC
TACGGTCAGTTCTGTAACGAAAACTTCTGGGCAGCAGCAAGTGTGTGTGAGCCAGGCCACCGTGGGAACCTGCAAGGCTGCCACCCCCAC
CGTCGTCAGCGCCACGTCCCTCGTGCCTACACCAAACCCCATCTCTGGGAAAGCCACAGTATCCGGACTGTTAAAGATTCACTCCAGTCA
GTCCAGTCCGCAGCAGGCCGTCCTGACGATTCCCAGCCAGCTCAAACCACTCAGCGTAAACACATCTGGAGGGGTGCAGACGATCCTGAT
GCCTGTGAATAAAGTGGTTCAGTCATTTTCTACCAGCAAGCCACCTGCCATTCTGCCTGTAGCTGCCCCAACTCCAGTTGTCCCCAGCTC
TGCTCCAGCAGCTGTTGCAAAAGTGAAGACTGAACCAGAAACACCTGGACCGAGTTGCCTCTCTCAGGAGGGTCAGACAGCAGTGAAAAC
AGAAGAAAGTTCTGAGCTGGGAAACTATGTCATTAAGATAGACCATTTAGAAACTATCCAGCAACTCCTAACTGCAGTAGTAAAGAAGAT
TCCATTAATCACTGCAAAAAGTGAAGATGCCAGCTGCTTTTCTGCAAAGTCTGTGGAGCAGTACTATGGCTGGAACATTGGAAAAAGGAG
AGCCGCTGAGTGGCAAAGAGCAATGACAATGCGAAAAGTCTTACAAGAAATCCTGGAGAAGAATCCGAGATTTCACCACCTGACTCCCCT
CAAAACCAAGCACATCGCTCACTGGTGCCGCTGTCATGGCTACACCCCACCGGACCCTGAGAGCCTGAGGAATGACGGGGACTCCATCGA
GGACGTGCTGACCCAGATCGACAGCGAGCCCGAGTGCCCATCATCATTCTCCTCTGCTGACAACCTCTGCCGCAAACTGGAGGACCTGCA
ACAGTTCCAGAAAAGGGAACCCGAGAATGAGGAGGAGGTGGACATCCTCAGCCTCTCCGAGCCAGTGAAGATAAACATCAAGAAGGAGCA
GGAAGAGAAACAAGAGGAAGTCAAGTTCTACCTGCCACCAACCCCAGGGTCTGAATTTATTGGGGATGTCACACAGAAGATTGGGATCAC
CCTGCAGCCCGTGGCACTCCACAGGAACGTGTATGCGTCCGTGGTGGAGGACATGATCCTGAAGGCTACAGAACAGCTGGTGAATGATAT
CCTGAGACAGGCTTTGGCAGTTGGATACCAGACAGCTTCTCACAACAGGATTCCCAAAGAAATTACAGTGAGTAATATTCACCAGGCCAT
TTGCAACATTCCTTTTCTGGACTTCCTCACAAACAAACACATGGGAATATTGAATGAGGACCAGTGAGCGGAGTGAGGTGCCCTGGAGAA
GCAGGCTTTGAAGGCACAGCGAAGCTGTAACTGAGGACCCTGCTGCTCGGGAAGGAGGTGGTTTCCAGTGTGACTCGGCATGTCATGGCT
ACCCAACCTTTGCCGCTGCCTGTTCCCACGTGTCACCAGCACGCTGCACTCCAGATGAAATCCTCCTAGGACAGGAGTTTGTTTCCTGAG
TGTGGAGTGAGGCTGTCAGTGGATCCGTGCTTTGTCGGCCAGCGTTTCTGCAGTCTTTGTAAAGGCCCCACGAGAGCGGGCCAGGCCGTG
TGCCTCAGGCCCTTCTCCCTGGGTGTGCTTAAGGGGGCTCCTTGGGCCCGCCTCCCCAGGAGGTAGAAAATGAGTGGCAGGCTAGAGATT
TCACCCATTTTGTGGGCTGGAGTTACCAGTAGCTCCAGCAGTTACCCTGAAGAGAGATTGGGCTTCAGCCTTCAGCAGGTGGTTCTCTCC
CATGCCTGGCCTTGGTGTGGAGGGGCTGTACTCTGAGCCCAAGTGAGTCAGCTATAGGAAGAGGCCATACCTAGAGCCAAGAACCATGAA
GGCCTGAGAGACGGCAGACTGAGCAGAATTCCTTTTTTGAGCACGAGAGCATTACTAGAACCATTGTCAAAGCAGTGGCAAGGGACGGAG
AGGTCCCAACAGGAGTCAGGAAGAGGTTTGATTATAACCAAGAAAACTCACTATGCTAGGAATAGACTGTGTGCACCAGTCCCAGACACT
TGGCAGAAGTGTAGCAGCGTTACACATGTGTGCGAAGCAGATCGCAGGTTCCACGCCATCTGCATGGCCTGCAGGAGCTTCTGCTGCTGA
CCCCATGCTGAGTGGCCAGTGGGGAGCGGCGCCCGGCAGGCTCTTCTGGGGTCGTCTGTCCTATCCGTGGATTGTATATACTCTTCTCTG
TTAAGGAGTTTTTCCCAAGAAGAAAAGTATTTAAAAGAAATACCAGTGAGTGCCTTAAAGTTGGAGAAGTAACTGCCCATGCCCAGAAAT
AAGGATGCCAGTGCCCAGAAGCAGTGAGATTAGTCTGTGTCCACAAGCAGAGGCCCCCTCGATGGGAGGGAGTGGCAGGCAGGAGAAGGT
GGCGCTGCCAGGTGCCCGGGTCTATTGGAGGCGCCCCATCTCAGACTTCCTAACACAGCCTGTGTGGAAGGCAGAACAAAGAATGCATGC
CCAGTCAGAAATCTGTTCTATTCTGCTCCAGGAAAATCGGAAACCTGTGAGTCAGAGTCAGAGAAACTTACCCAAGCAACGTAATTCCTG
TTTTCATGGGTCCTGTAGATGTTTGAGTCAGGAAGGTAAGGCGGGGAGTGACTGAATAAACTCTGCCTTTTAAATTGAGCATCTGGGCCG
GGCATGGTGGCTCACGCCTGTAATCCCAGCACTCTGGGAGGTCGAGGTGGGTGGGTCACCTGAGGTTGGGAGTTCGAGACCAGCCCGACC
AACATGGTGAAACCCCGTCTCTACTAAAAATACAGAAAATTAGCTGGGCATGGTGGTGTGTGCCTGTAATTCCAGCTACTCGGGAGGCTG
AGGCAGGAAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGTGCCAAGATCATACCACTGCACTCCAGCCCTGGTGACAGAGGAGAC
CCCGTCTCAAAAATTGATTGATCAATTCAGCATCTGAGGGCTGCAAGTACAGAAGGAATCTATTCTCAGCAGGGCATAGGGCACGCACTG
GCTTAACAGTTTAGTATATAAGGCTCAAATAGTCTATACCTGAACTGCTATAAGCAAGGTCGATAGGGAAGTGGATAGATTGCTTCAGCA
AAGTGAACTGTGAGATCTCCAGGACAGAGGGAGAAAGATCTGATCCAAATGAGAACAGATTGGTTATTGCAGGTATCACAGCCTAAAGAA
ATTATCTTTTTGCAAAAGAAATATTAAATGATTTAGCAGTCTCCACGTGTGTTAATGTTTCAAACGTGTATCATAATGTGTATAATTGTG

>349_349_1_ABCF3-YEATS2_ABCF3_chr3_183910684_ENST00000292808_YEATS2_chr3_183493703_ENST00000305135_length(amino acids)=1219AA_BP=584
MRGRVPEWNMATCAEILRSEFPEIDGQVFDYVTGVLHSGSADFESVDDLVEAVGELLQEVSGDSKDDAGIRAVCQRMAEPQSQGNSQVLL
DAPIQLSKITENYDCGTKLPGLLKREQSSTVNAKKLEKAEARLKAKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRLESSGKNKSYD
VRIENFDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPALQSVLESDSVREDLLRR
ERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNM
LDVRAILWLENYLQTWPSTILVVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERLLNQQREYEAQQQYRQHIQVFIDRFRYN
ANRASQVQSKLKMLEKLPELKPVDKESEVVMKFPDGFEKFSPPILQLDEVDFYYDPKHVIFSRLSVSADLESRICVVGENGAGKSTMLKL
LLGDLAPVRGIRHAHRNLKIGYFSQHHVEQLDLNVSAVELLARKFPDLQSGSAASGGSGAGGGGGGGGGGGSGSGGGGSTGGGGGTAGGG
TQSTAGPGGISQHLTYTSYILKQTPQGTFLVGQPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTTLFTQAAHGGQASLMK
ISDSTLKTVPATSQLSKPGTTMLRVAGGVITTATSPAVALSANGPAQQSEGMAPVSSSTVSSVTKTSGQQQVCVSQATVGTCKAATPTVV
SATSLVPTPNPISGKATVSGLLKIHSSQSSPQQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKPPAILPVAAPTPVVPSSAP
AAVAKVKTEPETPGPSCLSQEGQTAVKTEESSELGNYVIKIDHLETIQQLLTAVVKKIPLITAKSEDASCFSAKSVEQYYGWNIGKRRAA
EWQRAMTMRKVLQEILEKNPRFHHLTPLKTKHIAHWCRCHGYTPPDPESLRNDGDSIEDVLTQIDSEPECPSSFSSADNLCRKLEDLQQF
QKREPENEEEVDILSLSEPVKINIKKEQEEKQEEVKFYLPPTPGSEFIGDVTQKIGITLQPVALHRNVYASVVEDMILKATEQLVNDILR

--------------------------------------------------------------
>349_349_2_ABCF3-YEATS2_ABCF3_chr3_183910684_ENST00000429586_YEATS2_chr3_183493703_ENST00000305135_length(transcript)=5878nt_BP=1935nt
AGACTCGGCGCCTCTCCTCAAGGCCCCGCTCGCCCCGCCCACCGGGCTCTGCGCACTCCGCTCCTTTCCTGCGTCACCGCTACACATGCG
CCTTGCAAGGAAGGGCGAGATTTCGGGGGCAGGGCGGGGGGCGGGCCTAGGCCGGGGTCTCACAGCGACTGCGCGGACGGGTTCCTGAGT
GGAACATGGCGACTTGCGCCGAAATCCTGCGGAGCGAGTTCCCCGAAATTGACGGACAAGTCTTCGACTACGTGACCGGCGTCTTGCACA
GCGGCAGCGCGGACTTCGAGTCTGTGGATGACCTGGTGGAAGCTGTAGGGGAACTATTGCAAGAGGTGTCCGGGGACAGCAAGGATGACG
CGGGCATCAGGGCCGTGTGCCAGCGCATGTACAACACTCTGCGTCTGGCTGAGCCACAAAGCCAGGGAAATAGCCAGGTGCTACTGGACG
CCCCTATCCAGTTGTCAAAGATAACGGAGAACTACGACTGTGGAACCAAACTTCCAGGACTGCTAAAGAGGGAACAGTCCTCGACAGTGA
ATGCAAAGAAGTTAGAGAAGGCCGAGGCTCGACTTAAGGCAAAGCAGGAGAAGCGCTCAGAGAAGGACACGCTCAAGACCAGCAACCCTC
TAGTCTTAGAAGAGGCATCAGCCAGCCAGGCAGGCAGCAGAAAGGAGAGTCGGTTGGAATCATCTGGCAAGAACAAATCCTATGATGTGC
GAATTGAGAACTTTGATGTGTCTTTTGGCGATAGAGTACTGCTGGCTGGAGCGGATGTGAACCTGGCATGGGGCCGCCGTTACGGGCTGG
TGGGGCGGAATGGGTTGGGGAAGACAACGTTACTGAAGATGCTGGCCACCCGGAGTCTGCGGGTTCCAGCCCACATTTCCCTGCTGCACG
TTGAGCAAGAGGTTGCTGGAGATGACACTCCTGCCCTGCAGAGTGTGCTGGAGAGTGACAGTGTGCGAGAGGATTTGCTACGGAGGGAGC
GGGAGCTCACTGCCCAGATTGCTGCTGGCAGGGCGGAGGGCTCTGAAGCTGCAGAGCTGGCAGAAATCTATGCCAAACTGGAGGAGATTG
AGGCTGACAAGGCACCTGCCAGGGCATCAGTCATTCTCGCTGGGCTTGGCTTTACCCCTAAAATGCAGCAGCAGCCCACCCGGGAGTTCT
CAGGTGGCTGGAGGATGAGGCTGGCCCTGGCCCGGGCCCTCTTTGCTAGGCCAGATCTTCTGCTGTTAGATGAACCTACAAACATGCTGG
ATGTCAGGGCCATCCTGTGGCTGGAGAATTACCTGCAGACGTGGCCCTCCACCATCCTAGTCGTCTCCCACGACCGCAACTTCTTGAATG
CCATCGCCACAGACATCATCCACCTGCACAGCCAGCGGCTAGATGGTTACCGGGGAGACTTTGAGACCTTCATCAAGAGTAAGCAGGAGC
GGCTGCTCAACCAGCAGCGTGAATATGAGGCGCAGCAGCAGTATCGCCAGCACATCCAGGTTTTCATTGACCGGTTTCGCTACAATGCCA
ACAGGGCCTCTCAAGTGCAGAGTAAACTCAAGATGCTGGAGAAGCTGCCTGAGCTGAAGCCTGTGGACAAGGAATCAGAGGTCGTAATGA
AGTTCCCTGATGGGTTTGAGAAGTTCTCGCCGCCAATTCTGCAGCTAGATGAGGTGGATTTCTACTACGATCCGAAGCACGTCATCTTCA
GTCGCCTCTCTGTGTCTGCTGATCTCGAGTCTCGCATCTGTGTGGTTGGAGAGAATGGGGCTGGGAAGTCTACCATGCTGAAGCTGCTTT
TGGGGGACCTGGCACCTGTTCGGGGCATCAGACACGCTCACAGGAATCTGAAGATTGGCTATTTCAGCCAGCACCATGTGGAGCAGCTGG
ACCTAAACGTCAGTGCTGTGGAACTGCTGGCACGCAAGTTTCCTGATCTCCAGTCTGGCTCAGCTGCCAGTGGTGGGAGTGGTGCCGGAG
GAGGAGGAGGAGGAGGAGGAGGAGGCGGCAGTGGCAGCGGTGGAGGCGGCAGCACAGGAGGAGGAGGAGGAACAGCAGGAGGAGGAACTC
AAAGTACTGCTGGCCCTGGAGGGATATCTCAGCACCTGACTTACACATCTTACATCCTCAAGCAAACTCCCCAGGGCACATTTTTAGTTG
GCCAGCCATCACCCCAGACTTCTGGAAAACAACTCACCACTGGGTCAGTGGTCCAAGGAACACTGGGAGTCAGCACATCTTCTGCACAAG
GACAACAAACGCTAAAAGTCATCTCTGGACAGAAAACCACATTGTTTACACAGGCAGCCCATGGAGGACAGGCATCTCTAATGAAAATAT
CCGATAGCACCTTGAAGACTGTGCCAGCCACCTCACAGCTCTCGAAGCCTGGAACCACAATGCTGAGAGTAGCAGGAGGGGTTATCACAA
CTGCCACTTCCCCTGCCGTGGCCCTCTCAGCAAACGGTCCTGCACAACAGTCTGAAGGAATGGCTCCCGTGTCTTCATCTACGGTCAGTT
CTGTAACGAAAACTTCTGGGCAGCAGCAAGTGTGTGTGAGCCAGGCCACCGTGGGAACCTGCAAGGCTGCCACCCCCACCGTCGTCAGCG
CCACGTCCCTCGTGCCTACACCAAACCCCATCTCTGGGAAAGCCACAGTATCCGGACTGTTAAAGATTCACTCCAGTCAGTCCAGTCCGC
AGCAGGCCGTCCTGACGATTCCCAGCCAGCTCAAACCACTCAGCGTAAACACATCTGGAGGGGTGCAGACGATCCTGATGCCTGTGAATA
AAGTGGTTCAGTCATTTTCTACCAGCAAGCCACCTGCCATTCTGCCTGTAGCTGCCCCAACTCCAGTTGTCCCCAGCTCTGCTCCAGCAG
CTGTTGCAAAAGTGAAGACTGAACCAGAAACACCTGGACCGAGTTGCCTCTCTCAGGAGGGTCAGACAGCAGTGAAAACAGAAGAAAGTT
CTGAGCTGGGAAACTATGTCATTAAGATAGACCATTTAGAAACTATCCAGCAACTCCTAACTGCAGTAGTAAAGAAGATTCCATTAATCA
CTGCAAAAAGTGAAGATGCCAGCTGCTTTTCTGCAAAGTCTGTGGAGCAGTACTATGGCTGGAACATTGGAAAAAGGAGAGCCGCTGAGT
GGCAAAGAGCAATGACAATGCGAAAAGTCTTACAAGAAATCCTGGAGAAGAATCCGAGATTTCACCACCTGACTCCCCTCAAAACCAAGC
ACATCGCTCACTGGTGCCGCTGTCATGGCTACACCCCACCGGACCCTGAGAGCCTGAGGAATGACGGGGACTCCATCGAGGACGTGCTGA
CCCAGATCGACAGCGAGCCCGAGTGCCCATCATCATTCTCCTCTGCTGACAACCTCTGCCGCAAACTGGAGGACCTGCAACAGTTCCAGA
AAAGGGAACCCGAGAATGAGGAGGAGGTGGACATCCTCAGCCTCTCCGAGCCAGTGAAGATAAACATCAAGAAGGAGCAGGAAGAGAAAC
AAGAGGAAGTCAAGTTCTACCTGCCACCAACCCCAGGGTCTGAATTTATTGGGGATGTCACACAGAAGATTGGGATCACCCTGCAGCCCG
TGGCACTCCACAGGAACGTGTATGCGTCCGTGGTGGAGGACATGATCCTGAAGGCTACAGAACAGCTGGTGAATGATATCCTGAGACAGG
CTTTGGCAGTTGGATACCAGACAGCTTCTCACAACAGGATTCCCAAAGAAATTACAGTGAGTAATATTCACCAGGCCATTTGCAACATTC
CTTTTCTGGACTTCCTCACAAACAAACACATGGGAATATTGAATGAGGACCAGTGAGCGGAGTGAGGTGCCCTGGAGAAGCAGGCTTTGA
AGGCACAGCGAAGCTGTAACTGAGGACCCTGCTGCTCGGGAAGGAGGTGGTTTCCAGTGTGACTCGGCATGTCATGGCTACCCAACCTTT
GCCGCTGCCTGTTCCCACGTGTCACCAGCACGCTGCACTCCAGATGAAATCCTCCTAGGACAGGAGTTTGTTTCCTGAGTGTGGAGTGAG
GCTGTCAGTGGATCCGTGCTTTGTCGGCCAGCGTTTCTGCAGTCTTTGTAAAGGCCCCACGAGAGCGGGCCAGGCCGTGTGCCTCAGGCC
CTTCTCCCTGGGTGTGCTTAAGGGGGCTCCTTGGGCCCGCCTCCCCAGGAGGTAGAAAATGAGTGGCAGGCTAGAGATTTCACCCATTTT
GTGGGCTGGAGTTACCAGTAGCTCCAGCAGTTACCCTGAAGAGAGATTGGGCTTCAGCCTTCAGCAGGTGGTTCTCTCCCATGCCTGGCC
TTGGTGTGGAGGGGCTGTACTCTGAGCCCAAGTGAGTCAGCTATAGGAAGAGGCCATACCTAGAGCCAAGAACCATGAAGGCCTGAGAGA
CGGCAGACTGAGCAGAATTCCTTTTTTGAGCACGAGAGCATTACTAGAACCATTGTCAAAGCAGTGGCAAGGGACGGAGAGGTCCCAACA
GGAGTCAGGAAGAGGTTTGATTATAACCAAGAAAACTCACTATGCTAGGAATAGACTGTGTGCACCAGTCCCAGACACTTGGCAGAAGTG
TAGCAGCGTTACACATGTGTGCGAAGCAGATCGCAGGTTCCACGCCATCTGCATGGCCTGCAGGAGCTTCTGCTGCTGACCCCATGCTGA
GTGGCCAGTGGGGAGCGGCGCCCGGCAGGCTCTTCTGGGGTCGTCTGTCCTATCCGTGGATTGTATATACTCTTCTCTGTTAAGGAGTTT
TTCCCAAGAAGAAAAGTATTTAAAAGAAATACCAGTGAGTGCCTTAAAGTTGGAGAAGTAACTGCCCATGCCCAGAAATAAGGATGCCAG
TGCCCAGAAGCAGTGAGATTAGTCTGTGTCCACAAGCAGAGGCCCCCTCGATGGGAGGGAGTGGCAGGCAGGAGAAGGTGGCGCTGCCAG
GTGCCCGGGTCTATTGGAGGCGCCCCATCTCAGACTTCCTAACACAGCCTGTGTGGAAGGCAGAACAAAGAATGCATGCCCAGTCAGAAA
TCTGTTCTATTCTGCTCCAGGAAAATCGGAAACCTGTGAGTCAGAGTCAGAGAAACTTACCCAAGCAACGTAATTCCTGTTTTCATGGGT
CCTGTAGATGTTTGAGTCAGGAAGGTAAGGCGGGGAGTGACTGAATAAACTCTGCCTTTTAAATTGAGCATCTGGGCCGGGCATGGTGGC
TCACGCCTGTAATCCCAGCACTCTGGGAGGTCGAGGTGGGTGGGTCACCTGAGGTTGGGAGTTCGAGACCAGCCCGACCAACATGGTGAA
ACCCCGTCTCTACTAAAAATACAGAAAATTAGCTGGGCATGGTGGTGTGTGCCTGTAATTCCAGCTACTCGGGAGGCTGAGGCAGGAAGA
ATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGTGCCAAGATCATACCACTGCACTCCAGCCCTGGTGACAGAGGAGACCCCGTCTCAAA
AATTGATTGATCAATTCAGCATCTGAGGGCTGCAAGTACAGAAGGAATCTATTCTCAGCAGGGCATAGGGCACGCACTGGCTTAACAGTT
TAGTATATAAGGCTCAAATAGTCTATACCTGAACTGCTATAAGCAAGGTCGATAGGGAAGTGGATAGATTGCTTCAGCAAAGTGAACTGT
GAGATCTCCAGGACAGAGGGAGAAAGATCTGATCCAAATGAGAACAGATTGGTTATTGCAGGTATCACAGCCTAAAGAAATTATCTTTTT
GCAAAAGAAATATTAAATGATTTAGCAGTCTCCACGTGTGTTAATGTTTCAAACGTGTATCATAATGTGTATAATTGTGTAACAAAATTG

>349_349_2_ABCF3-YEATS2_ABCF3_chr3_183910684_ENST00000429586_YEATS2_chr3_183493703_ENST00000305135_length(amino acids)=1225AA_BP=590
MRGRVPEWNMATCAEILRSEFPEIDGQVFDYVTGVLHSGSADFESVDDLVEAVGELLQEVSGDSKDDAGIRAVCQRMYNTLRLAEPQSQG
NSQVLLDAPIQLSKITENYDCGTKLPGLLKREQSSTVNAKKLEKAEARLKAKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRLESSG
KNKSYDVRIENFDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPALQSVLESDSVR
EDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLL
DEPTNMLDVRAILWLENYLQTWPSTILVVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERLLNQQREYEAQQQYRQHIQVFI
DRFRYNANRASQVQSKLKMLEKLPELKPVDKESEVVMKFPDGFEKFSPPILQLDEVDFYYDPKHVIFSRLSVSADLESRICVVGENGAGK
STMLKLLLGDLAPVRGIRHAHRNLKIGYFSQHHVEQLDLNVSAVELLARKFPDLQSGSAASGGSGAGGGGGGGGGGGSGSGGGGSTGGGG
GTAGGGTQSTAGPGGISQHLTYTSYILKQTPQGTFLVGQPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTTLFTQAAHGG
QASLMKISDSTLKTVPATSQLSKPGTTMLRVAGGVITTATSPAVALSANGPAQQSEGMAPVSSSTVSSVTKTSGQQQVCVSQATVGTCKA
ATPTVVSATSLVPTPNPISGKATVSGLLKIHSSQSSPQQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKPPAILPVAAPTPV
VPSSAPAAVAKVKTEPETPGPSCLSQEGQTAVKTEESSELGNYVIKIDHLETIQQLLTAVVKKIPLITAKSEDASCFSAKSVEQYYGWNI
GKRRAAEWQRAMTMRKVLQEILEKNPRFHHLTPLKTKHIAHWCRCHGYTPPDPESLRNDGDSIEDVLTQIDSEPECPSSFSSADNLCRKL
EDLQQFQKREPENEEEVDILSLSEPVKINIKKEQEEKQEEVKFYLPPTPGSEFIGDVTQKIGITLQPVALHRNVYASVVEDMILKATEQL

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Fusion Gene PPI Analysis for ABCF3-YEATS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABCF3-YEATS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABCF3-YEATS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource