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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACER3-PPME1 (FusionGDB2 ID:HG55331TG51400)

Fusion Gene Summary for ACER3-PPME1

check button Fusion gene summary
Fusion gene informationFusion gene name: ACER3-PPME1
Fusion gene ID: hg55331tg51400
HgeneTgene
Gene symbol

ACER3

PPME1

Gene ID

55331

51400

Gene namealkaline ceramidase 3protein phosphatase methylesterase 1
SynonymsAPHC|PHCA|PLDECOABDH19|PME-1
Cytomap('ACER3')('PPME1')

11q13.5

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionalkaline ceramidase 3alkCDase 3alkaline CDase 3alkaline dihydroceramidase SB89alkaline phytoceramidasephytoceramidase, alkalineprotein phosphatase methylesterase 1testicular secretory protein Li 39
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000530182, ENST00000532485, 
ENST00000533873, ENST00000538157, 
ENST00000526597, ENST00000544113, 
Fusion gene scores* DoF score14 X 7 X 7=68610 X 7 X 6=420
# samples 1712
** MAII scorelog2(17/686*10)=-2.01267383003511
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/420*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACER3 [Title/Abstract] AND PPME1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACER3(76670075)-PPME1(73933357), # samples:3
Anticipated loss of major functional domain due to fusion event.ACER3-PPME1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACER3-PPME1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACER3

GO:0043067

regulation of programmed cell death

20068046

HgeneACER3

GO:0046512

sphingosine biosynthetic process

20068046

HgeneACER3

GO:0046514

ceramide catabolic process

30575723

HgeneACER3

GO:0071602

phytosphingosine biosynthetic process

11356846|20068046

TgenePPME1

GO:0006482

protein demethylation

10318862


check buttonFusion gene breakpoints across ACER3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PPME1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-05-5425-01AACER3chr11

76670075

-PPME1chr11

73933357

+
ChimerDB4LUADTCGA-05-5425-01AACER3chr11

76670075

+PPME1chr11

73933357

+


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Fusion Gene ORF analysis for ACER3-PPME1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000530182ENST00000328257ACER3chr11

76670075

+PPME1chr11

73933357

+
3UTR-3CDSENST00000530182ENST00000398427ACER3chr11

76670075

+PPME1chr11

73933357

+
3UTR-intronENST00000530182ENST00000542710ACER3chr11

76670075

+PPME1chr11

73933357

+
3UTR-intronENST00000530182ENST00000543525ACER3chr11

76670075

+PPME1chr11

73933357

+
5CDS-intronENST00000532485ENST00000542710ACER3chr11

76670075

+PPME1chr11

73933357

+
5CDS-intronENST00000532485ENST00000543525ACER3chr11

76670075

+PPME1chr11

73933357

+
5CDS-intronENST00000533873ENST00000542710ACER3chr11

76670075

+PPME1chr11

73933357

+
5CDS-intronENST00000533873ENST00000543525ACER3chr11

76670075

+PPME1chr11

73933357

+
5CDS-intronENST00000538157ENST00000542710ACER3chr11

76670075

+PPME1chr11

73933357

+
5CDS-intronENST00000538157ENST00000543525ACER3chr11

76670075

+PPME1chr11

73933357

+
In-frameENST00000532485ENST00000328257ACER3chr11

76670075

+PPME1chr11

73933357

+
In-frameENST00000532485ENST00000398427ACER3chr11

76670075

+PPME1chr11

73933357

+
In-frameENST00000533873ENST00000328257ACER3chr11

76670075

+PPME1chr11

73933357

+
In-frameENST00000533873ENST00000398427ACER3chr11

76670075

+PPME1chr11

73933357

+
In-frameENST00000538157ENST00000328257ACER3chr11

76670075

+PPME1chr11

73933357

+
In-frameENST00000538157ENST00000398427ACER3chr11

76670075

+PPME1chr11

73933357

+
intron-3CDSENST00000526597ENST00000328257ACER3chr11

76670075

+PPME1chr11

73933357

+
intron-3CDSENST00000526597ENST00000398427ACER3chr11

76670075

+PPME1chr11

73933357

+
intron-3CDSENST00000544113ENST00000328257ACER3chr11

76670075

+PPME1chr11

73933357

+
intron-3CDSENST00000544113ENST00000398427ACER3chr11

76670075

+PPME1chr11

73933357

+
intron-intronENST00000526597ENST00000542710ACER3chr11

76670075

+PPME1chr11

73933357

+
intron-intronENST00000526597ENST00000543525ACER3chr11

76670075

+PPME1chr11

73933357

+
intron-intronENST00000544113ENST00000542710ACER3chr11

76670075

+PPME1chr11

73933357

+
intron-intronENST00000544113ENST00000543525ACER3chr11

76670075

+PPME1chr11

73933357

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000532485ACER3chr1176670075+ENST00000328257PPME1chr1173933357+2437371801243387
ENST00000532485ACER3chr1176670075+ENST00000398427PPME1chr1173933357+2479371801285401
ENST00000533873ACER3chr1176670075+ENST00000328257PPME1chr1173933357+2257191111063350
ENST00000533873ACER3chr1176670075+ENST00000398427PPME1chr1173933357+2299191111105364
ENST00000538157ACER3chr1176670075+ENST00000328257PPME1chr1173933357+24043381911210339
ENST00000538157ACER3chr1176670075+ENST00000398427PPME1chr1173933357+24463381911252353

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000532485ENST00000328257ACER3chr1176670075+PPME1chr1173933357+0.0018671880.9981329
ENST00000532485ENST00000398427ACER3chr1176670075+PPME1chr1173933357+0.0019667590.9980332
ENST00000533873ENST00000328257ACER3chr1176670075+PPME1chr1173933357+0.0012046080.9987954
ENST00000533873ENST00000398427ACER3chr1176670075+PPME1chr1173933357+0.001066120.99893385
ENST00000538157ENST00000328257ACER3chr1176670075+PPME1chr1173933357+0.0012483210.99875164
ENST00000538157ENST00000398427ACER3chr1176670075+PPME1chr1173933357+0.0012153310.9987847

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Fusion Genomic Features for ACER3-PPME1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACER3chr1176670075+PPME1chr1173933356+0.197704820.8022952
ACER3chr1176670075+PPME1chr1173933356+0.197704820.8022952

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACER3-PPME1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:76670075/chr11:73933357)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACER3chr11:76670075chr11:73933357ENST00000532485+3111_3389268.0Topological domainCytoplasmic
HgeneACER3chr11:76670075chr11:73933357ENST00000532485+31156_6189268.0Topological domainLumenal
HgeneACER3chr11:76670075chr11:73933357ENST00000532485+31183_8789268.0Topological domainCytoplasmic
HgeneACER3chr11:76670075chr11:73933357ENST00000532485+31134_5589268.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:73933357ENST00000532485+31162_8289268.0TransmembraneHelical
TgenePPME1chr11:76670075chr11:73933357ENST00000328257214256_26396387.0Compositional biasNote=Poly-Glu
TgenePPME1chr11:76670075chr11:73933357ENST0000054352508256_2630200.0Compositional biasNote=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACER3chr11:76670075chr11:73933357ENST00000532485+311109_11889268.0Topological domainLumenal
HgeneACER3chr11:76670075chr11:73933357ENST00000532485+311140_14189268.0Topological domainCytoplasmic
HgeneACER3chr11:76670075chr11:73933357ENST00000532485+311163_17389268.0Topological domainLumenal
HgeneACER3chr11:76670075chr11:73933357ENST00000532485+311195_21589268.0Topological domainCytoplasmic
HgeneACER3chr11:76670075chr11:73933357ENST00000532485+311237_26789268.0Topological domainLumenal
HgeneACER3chr11:76670075chr11:73933357ENST00000544113+16109_1180135.0Topological domainLumenal
HgeneACER3chr11:76670075chr11:73933357ENST00000544113+16140_1410135.0Topological domainCytoplasmic
HgeneACER3chr11:76670075chr11:73933357ENST00000544113+16163_1730135.0Topological domainLumenal
HgeneACER3chr11:76670075chr11:73933357ENST00000544113+16195_2150135.0Topological domainCytoplasmic
HgeneACER3chr11:76670075chr11:73933357ENST00000544113+161_330135.0Topological domainCytoplasmic
HgeneACER3chr11:76670075chr11:73933357ENST00000544113+16237_2670135.0Topological domainLumenal
HgeneACER3chr11:76670075chr11:73933357ENST00000544113+1656_610135.0Topological domainLumenal
HgeneACER3chr11:76670075chr11:73933357ENST00000544113+1683_870135.0Topological domainCytoplasmic
HgeneACER3chr11:76670075chr11:73933357ENST00000532485+311119_13989268.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:73933357ENST00000532485+311142_16289268.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:73933357ENST00000532485+311174_19489268.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:73933357ENST00000532485+311216_23689268.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:73933357ENST00000532485+31188_10889268.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:73933357ENST00000544113+16119_1390135.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:73933357ENST00000544113+16142_1620135.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:73933357ENST00000544113+16174_1940135.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:73933357ENST00000544113+16216_2360135.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:73933357ENST00000544113+1634_550135.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:73933357ENST00000544113+1662_820135.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:73933357ENST00000544113+1688_1080135.0TransmembraneHelical


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Fusion Gene Sequence for ACER3-PPME1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1297_1297_1_ACER3-PPME1_ACER3_chr11_76670075_ENST00000532485_PPME1_chr11_73933357_ENST00000328257_length(transcript)=2437nt_BP=371nt
GGGCGGGGCGCGAGCGAGCGCGCGGGCTGGGCCGGAGCCGGCCTGGTCGCCAGCCTAACCCGGCACAGTGAGCGGAGCGCCTGGGCGGCG
GCGGCGGCGGCGTGATGGCTCCGGCCGCGGACCGAGAGGGCTACTGGGGCCCCACGACCTCCACGCTGGACTGGTGCGAGGAGAACTACT
CCGTGACCTGGTACATCGCCGAGTTCTGGAATACAGTGAGTAACCTGATCATGATTATACCTCCAATGTTCGGTGCAGTTCAGAGTGTTA
GAGACGGTCTGGAAAAGCGGTACATTGCTTCTTATTTAGCACTCACAGTGGTAGGAATGGGATCCTGGTGCTTCCACATGACTCTGAAAT
ATGAAATGCAGGCAGCGATTATTAGTAGAGTTCAGTGTAGGATTGTAGCTTTGGATCTGCGAAGTCATGGTGAAACAAAGGTCAAGAATC
CTGAAGATCTGTCTGCAGAAACAATGGCAAAAGACGTTGGCAATGTGGTTGAAGCCATGTATGGGGACCTTCCTCCTCCAATTATGCTGA
TTGGACATAGCATGGGTGGTGCTATTGCAGTCCACACAGCATCATCCAACCTGGTACCAAGCCTCTTGGGTCTGTGCATGATTGATGTTG
TAGAAGGTACAGCTATGGATGCACTTAATAGCATGCAGAATTTCTTACGGGGTCGTCCTAAAACCTTCAAGTCTCTGGAGAATGCTATTG
AATGGAGTGTGAAGAGTGGCCAGATTCGAAATCTGGAGTCTGCCCGTGTCTCAATGGTTGGCCAAGTCAAACAGTGTGAAGGAATTACAA
GTCCAGAAGGCTCAAAATCTATAGTGGAAGGAATCATAGAGGAAGAAGAAGAAGATGAGGAAGGAAGTGAGTCTATAAGCAAGAGGAAAA
AGGAAGATGACATGGAGACCAAGAAAGACCATCCATACACCTGGAGAATTGAACTGGCAAAAACAGAAAAATACTGGGACGGCTGGTTCC
GAGGCTTATCCAATCTCTTTCTTAGTTGTCCCATTCCTAAATTGCTGCTCTTGGCTGGTGTTGATAGATTGGATAAAGATCTGACCATTG
GCCAGATGCAAGGGAAGTTCCAGATGCAGGTCCTACCCCAGTGTGGCCATGCAGTCCATGAGGATGCCCCTGACAAGGTAGCTGAAGCTG
TTGCCACTTTCCTGATCCGGCACAGGTTTGCAGAACCCATCGGTGGATTCCAGTGTGTGTTTCCTGGCTGTTAGTGACCTGCTGTCCACC
CCTCCTCAACATCGAGCTCTGTTGTAAATACGTCGCACCAGAGGCCACTGTGATGCCACTGTCTCCTCTCCATCCCGCCCAGCCATGTGA
CACTGGCTCCCGGTAGACGGGCACCCCGAGATGTACCAACCTTTTCATGTATTCTGCCAAAAGCATTGTTTTCCAGGGCCCTTGACCAAC
ATCGGCTTCCCCAGTCCAGGGCTCCCCTGCTCCTTTCCCTTCCCTGTACTGGGGTAGCTCCTGCCTGCTCTCCCTGCGTTGCCTAGGGTA
AAGCCTCCAGATTTGCCATACTGAGCCCCTCTTCCTAGCATCAGGCGATACATCTGAGTTCAAATGTCTTCCCAGGCTCAGGGACCTCCA
TTCCTTGAGATTGTCTTGGCATGGCCCAGCCCTGCCTCATGGGATGGACAATGCATGGGGTGGTCTTTATTTTTCCCTTTCAAATAAAAC
ACTAGTCAGGTACCGTTTTATCCCAGTCGTACTCTTCCAGGTTTGGAAGACCCAGAGAGGCCAAGATCCCATCCTTAGCCATAGCGAGCG
GTGGTGGTGGATAGCATCACAAGAAACGAGCCTGAAAATCAGGTCCAGCCGGTCCAAGCACATGGCCTCCCATCTGGGAGAGCCCACTGT
CCCACTCCCACATGTCTGGGCACCTGCCCTGGGCTGAGGCCAGGCTGCTCCAGGGGCCTCCTGCGCCCTCACCTGCCACAGAGCAACCCA
GGTTAAATACAGCCCATGCACAAAGCCACAGGCCAAAGCCTATGGAATTGTTTTTAATCATCAAATTTAACCATTTTCATAACTGGTTCC
TGGAGGTGTGCAGTGCCCCCTTGCCTCTTCAAACCTACAGCTTCTCTTTGCCATTTGTGGATTTCACATCACTCCACACAGAAACATTAC
AGCCTGGCATCCCCAGTCTTTGCCTTCTTCCAGCTGCCTCGACACAGCACTGTGGCCTGTCCCTATTGCCCAGGCACGCCATTTCCAAGG
GCAGGAAGGGGCAGTGTCCTGAAGCCCATCTTTTCTGTGACTGTCTTAGGTGATGTGTAGCCCCCTCCACCTTTCCACTCAACAACCTCC
CACCCCTGTCCTGCTGCATGGTCCGGAGTCTGGGACCTACTTTGTTTTTTGTTATTTATGACCTTGTTTAAAGAAAATAAATATCTCCCA
ACCTTTA

>1297_1297_1_ACER3-PPME1_ACER3_chr11_76670075_ENST00000532485_PPME1_chr11_73933357_ENST00000328257_length(amino acids)=387AA_BP=97
MGGGGGGVMAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHM
TLKYEMQAAIISRVQCRIVALDLRSHGETKVKNPEDLSAETMAKDVGNVVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCM
IDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESIS
KRKKEDDMETKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKV
AEAVATFLIRHRFAEPIGGFQCVFPGC

--------------------------------------------------------------
>1297_1297_2_ACER3-PPME1_ACER3_chr11_76670075_ENST00000532485_PPME1_chr11_73933357_ENST00000398427_length(transcript)=2479nt_BP=371nt
GGGCGGGGCGCGAGCGAGCGCGCGGGCTGGGCCGGAGCCGGCCTGGTCGCCAGCCTAACCCGGCACAGTGAGCGGAGCGCCTGGGCGGCG
GCGGCGGCGGCGTGATGGCTCCGGCCGCGGACCGAGAGGGCTACTGGGGCCCCACGACCTCCACGCTGGACTGGTGCGAGGAGAACTACT
CCGTGACCTGGTACATCGCCGAGTTCTGGAATACAGTGAGTAACCTGATCATGATTATACCTCCAATGTTCGGTGCAGTTCAGAGTGTTA
GAGACGGTCTGGAAAAGCGGTACATTGCTTCTTATTTAGCACTCACAGTGGTAGGAATGGGATCCTGGTGCTTCCACATGACTCTGAAAT
ATGAAATGCAGGCAGCGATTATTAGTAGAGTTCAGTGTAGGATTGTAGCTTTGGATCTGCGAAGTCATGGTGAAACAAAGGTCAAGAATC
CTGAAGATCTGTCTGCAGAAACAATGGCAAAAGACGTTGGCAATGTGGTTGAAGCCATGTATGGGGACCTTCCTCCTCCAATTATGCTGA
TTGGACATAGCATGGGTGGTGCTATTGCAGTCCACACAGCATCATCCAACCTGGTACCAAGCCTCTTGGGTCTGTGCATGATTGATGTTG
TAGAAGGTACAGCTATGGATGCACTTAATAGCATGCAGAATTTCTTACGGGGTCGTCCTAAAACCTTCAAGTCTCTGGAGAATGCTATTG
AATGGAGTGTGAAGAGTGGCCAGATTCGAAATCTGGAGTCTGCCCGTGTCTCAATGGTTGGCCAAGTCAAACAGTGTGAAGGAATTACAA
GTCCAGAAGGCTCAAAATCTATAGTGGAAGGAATCATAGAGGAAGAAGAAGAAGATGAGGAAGGAAGTGAGTCTATAAGCAAGAGGAAAA
AGGAAGATGACATGGAGGGGTTGCCCTCGGAGACTCAGAACTTGCTCTTATTCCTCCAGACCAAGAAAGACCATCCATACACCTGGAGAA
TTGAACTGGCAAAAACAGAAAAATACTGGGACGGCTGGTTCCGAGGCTTATCCAATCTCTTTCTTAGTTGTCCCATTCCTAAATTGCTGC
TCTTGGCTGGTGTTGATAGATTGGATAAAGATCTGACCATTGGCCAGATGCAAGGGAAGTTCCAGATGCAGGTCCTACCCCAGTGTGGCC
ATGCAGTCCATGAGGATGCCCCTGACAAGGTAGCTGAAGCTGTTGCCACTTTCCTGATCCGGCACAGGTTTGCAGAACCCATCGGTGGAT
TCCAGTGTGTGTTTCCTGGCTGTTAGTGACCTGCTGTCCACCCCTCCTCAACATCGAGCTCTGTTGTAAATACGTCGCACCAGAGGCCAC
TGTGATGCCACTGTCTCCTCTCCATCCCGCCCAGCCATGTGACACTGGCTCCCGGTAGACGGGCACCCCGAGATGTACCAACCTTTTCAT
GTATTCTGCCAAAAGCATTGTTTTCCAGGGCCCTTGACCAACATCGGCTTCCCCAGTCCAGGGCTCCCCTGCTCCTTTCCCTTCCCTGTA
CTGGGGTAGCTCCTGCCTGCTCTCCCTGCGTTGCCTAGGGTAAAGCCTCCAGATTTGCCATACTGAGCCCCTCTTCCTAGCATCAGGCGA
TACATCTGAGTTCAAATGTCTTCCCAGGCTCAGGGACCTCCATTCCTTGAGATTGTCTTGGCATGGCCCAGCCCTGCCTCATGGGATGGA
CAATGCATGGGGTGGTCTTTATTTTTCCCTTTCAAATAAAACACTAGTCAGGTACCGTTTTATCCCAGTCGTACTCTTCCAGGTTTGGAA
GACCCAGAGAGGCCAAGATCCCATCCTTAGCCATAGCGAGCGGTGGTGGTGGATAGCATCACAAGAAACGAGCCTGAAAATCAGGTCCAG
CCGGTCCAAGCACATGGCCTCCCATCTGGGAGAGCCCACTGTCCCACTCCCACATGTCTGGGCACCTGCCCTGGGCTGAGGCCAGGCTGC
TCCAGGGGCCTCCTGCGCCCTCACCTGCCACAGAGCAACCCAGGTTAAATACAGCCCATGCACAAAGCCACAGGCCAAAGCCTATGGAAT
TGTTTTTAATCATCAAATTTAACCATTTTCATAACTGGTTCCTGGAGGTGTGCAGTGCCCCCTTGCCTCTTCAAACCTACAGCTTCTCTT
TGCCATTTGTGGATTTCACATCACTCCACACAGAAACATTACAGCCTGGCATCCCCAGTCTTTGCCTTCTTCCAGCTGCCTCGACACAGC
ACTGTGGCCTGTCCCTATTGCCCAGGCACGCCATTTCCAAGGGCAGGAAGGGGCAGTGTCCTGAAGCCCATCTTTTCTGTGACTGTCTTA
GGTGATGTGTAGCCCCCTCCACCTTTCCACTCAACAACCTCCCACCCCTGTCCTGCTGCATGGTCCGGAGTCTGGGACCTACTTTGTTTT
TTGTTATTTATGACCTTGTTTAAAGAAAATAAATATCTCCCAACCTTTA

>1297_1297_2_ACER3-PPME1_ACER3_chr11_76670075_ENST00000532485_PPME1_chr11_73933357_ENST00000398427_length(amino acids)=401AA_BP=97
MGGGGGGVMAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHM
TLKYEMQAAIISRVQCRIVALDLRSHGETKVKNPEDLSAETMAKDVGNVVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCM
IDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESIS
KRKKEDDMEGLPSETQNLLLFLQTKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLP
QCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC

--------------------------------------------------------------
>1297_1297_3_ACER3-PPME1_ACER3_chr11_76670075_ENST00000533873_PPME1_chr11_73933357_ENST00000328257_length(transcript)=2257nt_BP=191nt
GAGCGGAGCGCCTGGGCGGCGGCGGCGGCGGCGTGATGGCTCCGGCCGCGGACCGAGAGGGCTACTGGGGCCCCACGACCTCCACGCTGG
ACTGGTGCGAGGAGAACTACTCCGTGACCTGGTACATCGCCGAGTTCTTGGTAGGAATGGGATCCTGGTGCTTCCACATGACTCTGAAAT
ATGAAATGCAGGCAGCGATTATTAGTAGAGTTCAGTGTAGGATTGTAGCTTTGGATCTGCGAAGTCATGGTGAAACAAAGGTCAAGAATC
CTGAAGATCTGTCTGCAGAAACAATGGCAAAAGACGTTGGCAATGTGGTTGAAGCCATGTATGGGGACCTTCCTCCTCCAATTATGCTGA
TTGGACATAGCATGGGTGGTGCTATTGCAGTCCACACAGCATCATCCAACCTGGTACCAAGCCTCTTGGGTCTGTGCATGATTGATGTTG
TAGAAGGTACAGCTATGGATGCACTTAATAGCATGCAGAATTTCTTACGGGGTCGTCCTAAAACCTTCAAGTCTCTGGAGAATGCTATTG
AATGGAGTGTGAAGAGTGGCCAGATTCGAAATCTGGAGTCTGCCCGTGTCTCAATGGTTGGCCAAGTCAAACAGTGTGAAGGAATTACAA
GTCCAGAAGGCTCAAAATCTATAGTGGAAGGAATCATAGAGGAAGAAGAAGAAGATGAGGAAGGAAGTGAGTCTATAAGCAAGAGGAAAA
AGGAAGATGACATGGAGACCAAGAAAGACCATCCATACACCTGGAGAATTGAACTGGCAAAAACAGAAAAATACTGGGACGGCTGGTTCC
GAGGCTTATCCAATCTCTTTCTTAGTTGTCCCATTCCTAAATTGCTGCTCTTGGCTGGTGTTGATAGATTGGATAAAGATCTGACCATTG
GCCAGATGCAAGGGAAGTTCCAGATGCAGGTCCTACCCCAGTGTGGCCATGCAGTCCATGAGGATGCCCCTGACAAGGTAGCTGAAGCTG
TTGCCACTTTCCTGATCCGGCACAGGTTTGCAGAACCCATCGGTGGATTCCAGTGTGTGTTTCCTGGCTGTTAGTGACCTGCTGTCCACC
CCTCCTCAACATCGAGCTCTGTTGTAAATACGTCGCACCAGAGGCCACTGTGATGCCACTGTCTCCTCTCCATCCCGCCCAGCCATGTGA
CACTGGCTCCCGGTAGACGGGCACCCCGAGATGTACCAACCTTTTCATGTATTCTGCCAAAAGCATTGTTTTCCAGGGCCCTTGACCAAC
ATCGGCTTCCCCAGTCCAGGGCTCCCCTGCTCCTTTCCCTTCCCTGTACTGGGGTAGCTCCTGCCTGCTCTCCCTGCGTTGCCTAGGGTA
AAGCCTCCAGATTTGCCATACTGAGCCCCTCTTCCTAGCATCAGGCGATACATCTGAGTTCAAATGTCTTCCCAGGCTCAGGGACCTCCA
TTCCTTGAGATTGTCTTGGCATGGCCCAGCCCTGCCTCATGGGATGGACAATGCATGGGGTGGTCTTTATTTTTCCCTTTCAAATAAAAC
ACTAGTCAGGTACCGTTTTATCCCAGTCGTACTCTTCCAGGTTTGGAAGACCCAGAGAGGCCAAGATCCCATCCTTAGCCATAGCGAGCG
GTGGTGGTGGATAGCATCACAAGAAACGAGCCTGAAAATCAGGTCCAGCCGGTCCAAGCACATGGCCTCCCATCTGGGAGAGCCCACTGT
CCCACTCCCACATGTCTGGGCACCTGCCCTGGGCTGAGGCCAGGCTGCTCCAGGGGCCTCCTGCGCCCTCACCTGCCACAGAGCAACCCA
GGTTAAATACAGCCCATGCACAAAGCCACAGGCCAAAGCCTATGGAATTGTTTTTAATCATCAAATTTAACCATTTTCATAACTGGTTCC
TGGAGGTGTGCAGTGCCCCCTTGCCTCTTCAAACCTACAGCTTCTCTTTGCCATTTGTGGATTTCACATCACTCCACACAGAAACATTAC
AGCCTGGCATCCCCAGTCTTTGCCTTCTTCCAGCTGCCTCGACACAGCACTGTGGCCTGTCCCTATTGCCCAGGCACGCCATTTCCAAGG
GCAGGAAGGGGCAGTGTCCTGAAGCCCATCTTTTCTGTGACTGTCTTAGGTGATGTGTAGCCCCCTCCACCTTTCCACTCAACAACCTCC
CACCCCTGTCCTGCTGCATGGTCCGGAGTCTGGGACCTACTTTGTTTTTTGTTATTTATGACCTTGTTTAAAGAAAATAAATATCTCCCA
ACCTTTA

>1297_1297_3_ACER3-PPME1_ACER3_chr11_76670075_ENST00000533873_PPME1_chr11_73933357_ENST00000328257_length(amino acids)=350AA_BP=60
MGGGGGGVMAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFLVGMGSWCFHMTLKYEMQAAIISRVQCRIVALDLRSHGETKVKNPEDL
SAETMAKDVGNVVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSV
KSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESISKRKKEDDMETKKDHPYTWRIELAKTEKYWDGWFRGLS
NLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC

--------------------------------------------------------------
>1297_1297_4_ACER3-PPME1_ACER3_chr11_76670075_ENST00000533873_PPME1_chr11_73933357_ENST00000398427_length(transcript)=2299nt_BP=191nt
GAGCGGAGCGCCTGGGCGGCGGCGGCGGCGGCGTGATGGCTCCGGCCGCGGACCGAGAGGGCTACTGGGGCCCCACGACCTCCACGCTGG
ACTGGTGCGAGGAGAACTACTCCGTGACCTGGTACATCGCCGAGTTCTTGGTAGGAATGGGATCCTGGTGCTTCCACATGACTCTGAAAT
ATGAAATGCAGGCAGCGATTATTAGTAGAGTTCAGTGTAGGATTGTAGCTTTGGATCTGCGAAGTCATGGTGAAACAAAGGTCAAGAATC
CTGAAGATCTGTCTGCAGAAACAATGGCAAAAGACGTTGGCAATGTGGTTGAAGCCATGTATGGGGACCTTCCTCCTCCAATTATGCTGA
TTGGACATAGCATGGGTGGTGCTATTGCAGTCCACACAGCATCATCCAACCTGGTACCAAGCCTCTTGGGTCTGTGCATGATTGATGTTG
TAGAAGGTACAGCTATGGATGCACTTAATAGCATGCAGAATTTCTTACGGGGTCGTCCTAAAACCTTCAAGTCTCTGGAGAATGCTATTG
AATGGAGTGTGAAGAGTGGCCAGATTCGAAATCTGGAGTCTGCCCGTGTCTCAATGGTTGGCCAAGTCAAACAGTGTGAAGGAATTACAA
GTCCAGAAGGCTCAAAATCTATAGTGGAAGGAATCATAGAGGAAGAAGAAGAAGATGAGGAAGGAAGTGAGTCTATAAGCAAGAGGAAAA
AGGAAGATGACATGGAGGGGTTGCCCTCGGAGACTCAGAACTTGCTCTTATTCCTCCAGACCAAGAAAGACCATCCATACACCTGGAGAA
TTGAACTGGCAAAAACAGAAAAATACTGGGACGGCTGGTTCCGAGGCTTATCCAATCTCTTTCTTAGTTGTCCCATTCCTAAATTGCTGC
TCTTGGCTGGTGTTGATAGATTGGATAAAGATCTGACCATTGGCCAGATGCAAGGGAAGTTCCAGATGCAGGTCCTACCCCAGTGTGGCC
ATGCAGTCCATGAGGATGCCCCTGACAAGGTAGCTGAAGCTGTTGCCACTTTCCTGATCCGGCACAGGTTTGCAGAACCCATCGGTGGAT
TCCAGTGTGTGTTTCCTGGCTGTTAGTGACCTGCTGTCCACCCCTCCTCAACATCGAGCTCTGTTGTAAATACGTCGCACCAGAGGCCAC
TGTGATGCCACTGTCTCCTCTCCATCCCGCCCAGCCATGTGACACTGGCTCCCGGTAGACGGGCACCCCGAGATGTACCAACCTTTTCAT
GTATTCTGCCAAAAGCATTGTTTTCCAGGGCCCTTGACCAACATCGGCTTCCCCAGTCCAGGGCTCCCCTGCTCCTTTCCCTTCCCTGTA
CTGGGGTAGCTCCTGCCTGCTCTCCCTGCGTTGCCTAGGGTAAAGCCTCCAGATTTGCCATACTGAGCCCCTCTTCCTAGCATCAGGCGA
TACATCTGAGTTCAAATGTCTTCCCAGGCTCAGGGACCTCCATTCCTTGAGATTGTCTTGGCATGGCCCAGCCCTGCCTCATGGGATGGA
CAATGCATGGGGTGGTCTTTATTTTTCCCTTTCAAATAAAACACTAGTCAGGTACCGTTTTATCCCAGTCGTACTCTTCCAGGTTTGGAA
GACCCAGAGAGGCCAAGATCCCATCCTTAGCCATAGCGAGCGGTGGTGGTGGATAGCATCACAAGAAACGAGCCTGAAAATCAGGTCCAG
CCGGTCCAAGCACATGGCCTCCCATCTGGGAGAGCCCACTGTCCCACTCCCACATGTCTGGGCACCTGCCCTGGGCTGAGGCCAGGCTGC
TCCAGGGGCCTCCTGCGCCCTCACCTGCCACAGAGCAACCCAGGTTAAATACAGCCCATGCACAAAGCCACAGGCCAAAGCCTATGGAAT
TGTTTTTAATCATCAAATTTAACCATTTTCATAACTGGTTCCTGGAGGTGTGCAGTGCCCCCTTGCCTCTTCAAACCTACAGCTTCTCTT
TGCCATTTGTGGATTTCACATCACTCCACACAGAAACATTACAGCCTGGCATCCCCAGTCTTTGCCTTCTTCCAGCTGCCTCGACACAGC
ACTGTGGCCTGTCCCTATTGCCCAGGCACGCCATTTCCAAGGGCAGGAAGGGGCAGTGTCCTGAAGCCCATCTTTTCTGTGACTGTCTTA
GGTGATGTGTAGCCCCCTCCACCTTTCCACTCAACAACCTCCCACCCCTGTCCTGCTGCATGGTCCGGAGTCTGGGACCTACTTTGTTTT
TTGTTATTTATGACCTTGTTTAAAGAAAATAAATATCTCCCAACCTTTA

>1297_1297_4_ACER3-PPME1_ACER3_chr11_76670075_ENST00000533873_PPME1_chr11_73933357_ENST00000398427_length(amino acids)=364AA_BP=60
MGGGGGGVMAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFLVGMGSWCFHMTLKYEMQAAIISRVQCRIVALDLRSHGETKVKNPEDL
SAETMAKDVGNVVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSV
KSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESISKRKKEDDMEGLPSETQNLLLFLQTKKDHPYTWRIELA
KTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCV
FPGC

--------------------------------------------------------------
>1297_1297_5_ACER3-PPME1_ACER3_chr11_76670075_ENST00000538157_PPME1_chr11_73933357_ENST00000328257_length(transcript)=2404nt_BP=338nt
AGCGGAGCGCCTGGGCGGCGGCGGCGGCGGCGTGATGGCTCCGGCCGCGGACCGAGAGGGCTACTGGGGCCCCACGACCTCCACGCTGGA
CTGGTGCGAGGAGAACTACTCCGTGACCTGGTACATCGCCGAGTTCTGTTCCTTCCTACCATCCTCCCTGAAGAGCAACCTCAAGGAATA
CAGTGAGTAACCTGATCATGATTATACCTCCAATGTTCGGTGCAGTTCAGAGTGTTAGAGACGGTCTGGAAAAGCGGTACATTGCTTCTT
ATTTAGCACTCACAGTGGTAGGAATGGGATCCTGGTGCTTCCACATGACTCTGAAATATGAAATGCAGGCAGCGATTATTAGTAGAGTTC
AGTGTAGGATTGTAGCTTTGGATCTGCGAAGTCATGGTGAAACAAAGGTCAAGAATCCTGAAGATCTGTCTGCAGAAACAATGGCAAAAG
ACGTTGGCAATGTGGTTGAAGCCATGTATGGGGACCTTCCTCCTCCAATTATGCTGATTGGACATAGCATGGGTGGTGCTATTGCAGTCC
ACACAGCATCATCCAACCTGGTACCAAGCCTCTTGGGTCTGTGCATGATTGATGTTGTAGAAGGTACAGCTATGGATGCACTTAATAGCA
TGCAGAATTTCTTACGGGGTCGTCCTAAAACCTTCAAGTCTCTGGAGAATGCTATTGAATGGAGTGTGAAGAGTGGCCAGATTCGAAATC
TGGAGTCTGCCCGTGTCTCAATGGTTGGCCAAGTCAAACAGTGTGAAGGAATTACAAGTCCAGAAGGCTCAAAATCTATAGTGGAAGGAA
TCATAGAGGAAGAAGAAGAAGATGAGGAAGGAAGTGAGTCTATAAGCAAGAGGAAAAAGGAAGATGACATGGAGACCAAGAAAGACCATC
CATACACCTGGAGAATTGAACTGGCAAAAACAGAAAAATACTGGGACGGCTGGTTCCGAGGCTTATCCAATCTCTTTCTTAGTTGTCCCA
TTCCTAAATTGCTGCTCTTGGCTGGTGTTGATAGATTGGATAAAGATCTGACCATTGGCCAGATGCAAGGGAAGTTCCAGATGCAGGTCC
TACCCCAGTGTGGCCATGCAGTCCATGAGGATGCCCCTGACAAGGTAGCTGAAGCTGTTGCCACTTTCCTGATCCGGCACAGGTTTGCAG
AACCCATCGGTGGATTCCAGTGTGTGTTTCCTGGCTGTTAGTGACCTGCTGTCCACCCCTCCTCAACATCGAGCTCTGTTGTAAATACGT
CGCACCAGAGGCCACTGTGATGCCACTGTCTCCTCTCCATCCCGCCCAGCCATGTGACACTGGCTCCCGGTAGACGGGCACCCCGAGATG
TACCAACCTTTTCATGTATTCTGCCAAAAGCATTGTTTTCCAGGGCCCTTGACCAACATCGGCTTCCCCAGTCCAGGGCTCCCCTGCTCC
TTTCCCTTCCCTGTACTGGGGTAGCTCCTGCCTGCTCTCCCTGCGTTGCCTAGGGTAAAGCCTCCAGATTTGCCATACTGAGCCCCTCTT
CCTAGCATCAGGCGATACATCTGAGTTCAAATGTCTTCCCAGGCTCAGGGACCTCCATTCCTTGAGATTGTCTTGGCATGGCCCAGCCCT
GCCTCATGGGATGGACAATGCATGGGGTGGTCTTTATTTTTCCCTTTCAAATAAAACACTAGTCAGGTACCGTTTTATCCCAGTCGTACT
CTTCCAGGTTTGGAAGACCCAGAGAGGCCAAGATCCCATCCTTAGCCATAGCGAGCGGTGGTGGTGGATAGCATCACAAGAAACGAGCCT
GAAAATCAGGTCCAGCCGGTCCAAGCACATGGCCTCCCATCTGGGAGAGCCCACTGTCCCACTCCCACATGTCTGGGCACCTGCCCTGGG
CTGAGGCCAGGCTGCTCCAGGGGCCTCCTGCGCCCTCACCTGCCACAGAGCAACCCAGGTTAAATACAGCCCATGCACAAAGCCACAGGC
CAAAGCCTATGGAATTGTTTTTAATCATCAAATTTAACCATTTTCATAACTGGTTCCTGGAGGTGTGCAGTGCCCCCTTGCCTCTTCAAA
CCTACAGCTTCTCTTTGCCATTTGTGGATTTCACATCACTCCACACAGAAACATTACAGCCTGGCATCCCCAGTCTTTGCCTTCTTCCAG
CTGCCTCGACACAGCACTGTGGCCTGTCCCTATTGCCCAGGCACGCCATTTCCAAGGGCAGGAAGGGGCAGTGTCCTGAAGCCCATCTTT
TCTGTGACTGTCTTAGGTGATGTGTAGCCCCCTCCACCTTTCCACTCAACAACCTCCCACCCCTGTCCTGCTGCATGGTCCGGAGTCTGG
GACCTACTTTGTTTTTTGTTATTTATGACCTTGTTTAAAGAAAATAAATATCTCCCAACCTTTA

>1297_1297_5_ACER3-PPME1_ACER3_chr11_76670075_ENST00000538157_PPME1_chr11_73933357_ENST00000328257_length(amino acids)=339AA_BP=49
MIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQAAIISRVQCRIVALDLRSHGETKVKNPEDLSAETMAKDVGN
VVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESA
RVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESISKRKKEDDMETKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKL
LLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC

--------------------------------------------------------------
>1297_1297_6_ACER3-PPME1_ACER3_chr11_76670075_ENST00000538157_PPME1_chr11_73933357_ENST00000398427_length(transcript)=2446nt_BP=338nt
AGCGGAGCGCCTGGGCGGCGGCGGCGGCGGCGTGATGGCTCCGGCCGCGGACCGAGAGGGCTACTGGGGCCCCACGACCTCCACGCTGGA
CTGGTGCGAGGAGAACTACTCCGTGACCTGGTACATCGCCGAGTTCTGTTCCTTCCTACCATCCTCCCTGAAGAGCAACCTCAAGGAATA
CAGTGAGTAACCTGATCATGATTATACCTCCAATGTTCGGTGCAGTTCAGAGTGTTAGAGACGGTCTGGAAAAGCGGTACATTGCTTCTT
ATTTAGCACTCACAGTGGTAGGAATGGGATCCTGGTGCTTCCACATGACTCTGAAATATGAAATGCAGGCAGCGATTATTAGTAGAGTTC
AGTGTAGGATTGTAGCTTTGGATCTGCGAAGTCATGGTGAAACAAAGGTCAAGAATCCTGAAGATCTGTCTGCAGAAACAATGGCAAAAG
ACGTTGGCAATGTGGTTGAAGCCATGTATGGGGACCTTCCTCCTCCAATTATGCTGATTGGACATAGCATGGGTGGTGCTATTGCAGTCC
ACACAGCATCATCCAACCTGGTACCAAGCCTCTTGGGTCTGTGCATGATTGATGTTGTAGAAGGTACAGCTATGGATGCACTTAATAGCA
TGCAGAATTTCTTACGGGGTCGTCCTAAAACCTTCAAGTCTCTGGAGAATGCTATTGAATGGAGTGTGAAGAGTGGCCAGATTCGAAATC
TGGAGTCTGCCCGTGTCTCAATGGTTGGCCAAGTCAAACAGTGTGAAGGAATTACAAGTCCAGAAGGCTCAAAATCTATAGTGGAAGGAA
TCATAGAGGAAGAAGAAGAAGATGAGGAAGGAAGTGAGTCTATAAGCAAGAGGAAAAAGGAAGATGACATGGAGGGGTTGCCCTCGGAGA
CTCAGAACTTGCTCTTATTCCTCCAGACCAAGAAAGACCATCCATACACCTGGAGAATTGAACTGGCAAAAACAGAAAAATACTGGGACG
GCTGGTTCCGAGGCTTATCCAATCTCTTTCTTAGTTGTCCCATTCCTAAATTGCTGCTCTTGGCTGGTGTTGATAGATTGGATAAAGATC
TGACCATTGGCCAGATGCAAGGGAAGTTCCAGATGCAGGTCCTACCCCAGTGTGGCCATGCAGTCCATGAGGATGCCCCTGACAAGGTAG
CTGAAGCTGTTGCCACTTTCCTGATCCGGCACAGGTTTGCAGAACCCATCGGTGGATTCCAGTGTGTGTTTCCTGGCTGTTAGTGACCTG
CTGTCCACCCCTCCTCAACATCGAGCTCTGTTGTAAATACGTCGCACCAGAGGCCACTGTGATGCCACTGTCTCCTCTCCATCCCGCCCA
GCCATGTGACACTGGCTCCCGGTAGACGGGCACCCCGAGATGTACCAACCTTTTCATGTATTCTGCCAAAAGCATTGTTTTCCAGGGCCC
TTGACCAACATCGGCTTCCCCAGTCCAGGGCTCCCCTGCTCCTTTCCCTTCCCTGTACTGGGGTAGCTCCTGCCTGCTCTCCCTGCGTTG
CCTAGGGTAAAGCCTCCAGATTTGCCATACTGAGCCCCTCTTCCTAGCATCAGGCGATACATCTGAGTTCAAATGTCTTCCCAGGCTCAG
GGACCTCCATTCCTTGAGATTGTCTTGGCATGGCCCAGCCCTGCCTCATGGGATGGACAATGCATGGGGTGGTCTTTATTTTTCCCTTTC
AAATAAAACACTAGTCAGGTACCGTTTTATCCCAGTCGTACTCTTCCAGGTTTGGAAGACCCAGAGAGGCCAAGATCCCATCCTTAGCCA
TAGCGAGCGGTGGTGGTGGATAGCATCACAAGAAACGAGCCTGAAAATCAGGTCCAGCCGGTCCAAGCACATGGCCTCCCATCTGGGAGA
GCCCACTGTCCCACTCCCACATGTCTGGGCACCTGCCCTGGGCTGAGGCCAGGCTGCTCCAGGGGCCTCCTGCGCCCTCACCTGCCACAG
AGCAACCCAGGTTAAATACAGCCCATGCACAAAGCCACAGGCCAAAGCCTATGGAATTGTTTTTAATCATCAAATTTAACCATTTTCATA
ACTGGTTCCTGGAGGTGTGCAGTGCCCCCTTGCCTCTTCAAACCTACAGCTTCTCTTTGCCATTTGTGGATTTCACATCACTCCACACAG
AAACATTACAGCCTGGCATCCCCAGTCTTTGCCTTCTTCCAGCTGCCTCGACACAGCACTGTGGCCTGTCCCTATTGCCCAGGCACGCCA
TTTCCAAGGGCAGGAAGGGGCAGTGTCCTGAAGCCCATCTTTTCTGTGACTGTCTTAGGTGATGTGTAGCCCCCTCCACCTTTCCACTCA
ACAACCTCCCACCCCTGTCCTGCTGCATGGTCCGGAGTCTGGGACCTACTTTGTTTTTTGTTATTTATGACCTTGTTTAAAGAAAATAAA
TATCTCCCAACCTTTA

>1297_1297_6_ACER3-PPME1_ACER3_chr11_76670075_ENST00000538157_PPME1_chr11_73933357_ENST00000398427_length(amino acids)=353AA_BP=49
MIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQAAIISRVQCRIVALDLRSHGETKVKNPEDLSAETMAKDVGN
VVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESA
RVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESISKRKKEDDMEGLPSETQNLLLFLQTKKDHPYTWRIELAKTEKYWDGWFR
GLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACER3-PPME1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACER3-PPME1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACER3-PPME1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACER3C4540358LEUKODYSTROPHY, PROGRESSIVE, EARLY CHILDHOOD-ONSET2ORPHANET;UNIPROT
HgeneACER3C0025202melanoma1CTD_human