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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRR5-ARHGAP8 (FusionGDB2 ID:HG55615TG23779)

Fusion Gene Summary for PRR5-ARHGAP8

check button Fusion gene summary
Fusion gene informationFusion gene name: PRR5-ARHGAP8
Fusion gene ID: hg55615tg23779
HgeneTgene
Gene symbol

PRR5

ARHGAP8

Gene ID

55615

23779

Gene nameproline rich 5Rho GTPase activating protein 8
SynonymsFLJ20185k|PP610|PROTOR-1|PROTOR1BPGAP1|PP610
Cytomap('PRR5')('ARHGAP8')

22q13.31

22q13.31

Type of geneprotein-codingprotein-coding
Descriptionproline-rich protein 5Rho GTPase activating protein 8proline rich 5 (renal)protein observed with Rictor-1rho GTPase-activating protein 8BCH domain-containing Cdc42GAP-like proteinBNIP-2 and Cdc42GAP homology domain-containing, proline-rich and Cdc42GAP-like protein subtype-1rho-type GTPase-activating protein 8
Modification date2020031320200313
UniProtAcc.

P85298

Ensembl transtripts involved in fusion geneENST00000477331, ENST00000006251, 
ENST00000336985, ENST00000403581, 
ENST00000006251, ENST00000336985, 
ENST00000403581, ENST00000477331, 
Fusion gene scores* DoF score4 X 6 X 3=726 X 9 X 5=270
# samples 57
** MAII scorelog2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/270*10)=-1.94753258010586
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRR5 [Title/Abstract] AND ARHGAP8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRR5(45110550)-ARHGAP8(45241148), # samples:1
PRR5(45122513)-ARHGAP8(45241148), # samples:1
PRR5(NA)-ARHGAP8(NA), # samples:1
PRR5(45122514)-ARHGAP8(45182337), # samples:1
Anticipated loss of major functional domain due to fusion event.PRR5-ARHGAP8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PRR5-ARHGAP8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PRR5-ARHGAP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PRR5-ARHGAP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PRR5-ARHGAP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PRR5-ARHGAP8 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARHGAP8

GO:0070374

positive regulation of ERK1 and ERK2 cascade

20179103


check buttonFusion gene breakpoints across PRR5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ARHGAP8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-60-2698-01APRR5chr22

45110550

+ARHGAP8chr22

45241148

+
ChimerDB4LUSCTCGA-60-2698-01APRR5chr22

45122513

+ARHGAP8chr22

45241148

+


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Fusion Gene ORF analysis for PRR5-ARHGAP8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000477331ENST00000336963PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
3UTR-3CDSENST00000477331ENST00000336963PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
3UTR-3CDSENST00000477331ENST00000356099PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
3UTR-3CDSENST00000477331ENST00000356099PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
3UTR-3CDSENST00000477331ENST00000389773PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
3UTR-3CDSENST00000477331ENST00000389773PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
3UTR-3CDSENST00000477331ENST00000389774PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
3UTR-3CDSENST00000477331ENST00000389774PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
3UTR-3CDSENST00000477331ENST00000517296PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
3UTR-3CDSENST00000477331ENST00000517296PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
3UTR-intronENST00000477331ENST00000469872PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
3UTR-intronENST00000477331ENST00000469872PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
5CDS-intronENST00000006251ENST00000469872PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
5CDS-intronENST00000006251ENST00000469872PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
5CDS-intronENST00000336985ENST00000469872PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
5CDS-intronENST00000336985ENST00000469872PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
5CDS-intronENST00000403581ENST00000469872PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
5CDS-intronENST00000403581ENST00000469872PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
Frame-shiftENST00000006251ENST00000336963PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
Frame-shiftENST00000006251ENST00000356099PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
Frame-shiftENST00000006251ENST00000389773PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
Frame-shiftENST00000006251ENST00000389774PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
Frame-shiftENST00000006251ENST00000517296PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
Frame-shiftENST00000336985ENST00000336963PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
Frame-shiftENST00000336985ENST00000356099PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
Frame-shiftENST00000336985ENST00000389773PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
Frame-shiftENST00000336985ENST00000389774PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
Frame-shiftENST00000336985ENST00000517296PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
Frame-shiftENST00000403581ENST00000336963PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
Frame-shiftENST00000403581ENST00000356099PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
Frame-shiftENST00000403581ENST00000389773PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
Frame-shiftENST00000403581ENST00000389774PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
Frame-shiftENST00000403581ENST00000517296PRR5chr22

45122513

+ARHGAP8chr22

45241148

+
In-frameENST00000006251ENST00000336963PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
In-frameENST00000006251ENST00000356099PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
In-frameENST00000006251ENST00000389773PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
In-frameENST00000006251ENST00000389774PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
In-frameENST00000006251ENST00000517296PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
In-frameENST00000336985ENST00000336963PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
In-frameENST00000336985ENST00000356099PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
In-frameENST00000336985ENST00000389773PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
In-frameENST00000336985ENST00000389774PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
In-frameENST00000336985ENST00000517296PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
In-frameENST00000403581ENST00000336963PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
In-frameENST00000403581ENST00000356099PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
In-frameENST00000403581ENST00000389773PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
In-frameENST00000403581ENST00000389774PRR5chr22

45110550

+ARHGAP8chr22

45241148

+
In-frameENST00000403581ENST00000517296PRR5chr22

45110550

+ARHGAP8chr22

45241148

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000006251PRR5chr2245110550+ENST00000517296ARHGAP8chr2245241148+1199382411087348
ENST00000006251PRR5chr2245110550+ENST00000389773ARHGAP8chr2245241148+1277382411087348
ENST00000006251PRR5chr2245110550+ENST00000389774ARHGAP8chr2245241148+1277382411087348
ENST00000006251PRR5chr2245110550+ENST00000336963ARHGAP8chr2245241148+117438241703220
ENST00000006251PRR5chr2245110550+ENST00000356099ARHGAP8chr2245241148+1277382411087348
ENST00000403581PRR5chr2245110550+ENST00000517296ARHGAP8chr2245241148+17108935881598336
ENST00000403581PRR5chr2245110550+ENST00000389773ARHGAP8chr2245241148+17888935881598336
ENST00000403581PRR5chr2245110550+ENST00000389774ARHGAP8chr2245241148+17888935881598336
ENST00000403581PRR5chr2245110550+ENST00000336963ARHGAP8chr2245241148+16858931295627222
ENST00000403581PRR5chr2245110550+ENST00000356099ARHGAP8chr2245241148+17888935881598336
ENST00000336985PRR5chr2245110550+ENST00000517296ARHGAP8chr2245241148+13094922771197306
ENST00000336985PRR5chr2245110550+ENST00000389773ARHGAP8chr2245241148+13874922771197306
ENST00000336985PRR5chr2245110550+ENST00000389774ARHGAP8chr2245241148+13874922771197306
ENST00000336985PRR5chr2245110550+ENST00000336963ARHGAP8chr2245241148+1284492277813178
ENST00000336985PRR5chr2245110550+ENST00000356099ARHGAP8chr2245241148+13874922771197306

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000006251ENST00000517296PRR5chr2245110550+ARHGAP8chr2245241148+0.093763340.9062367
ENST00000006251ENST00000389773PRR5chr2245110550+ARHGAP8chr2245241148+0.090124620.9098754
ENST00000006251ENST00000389774PRR5chr2245110550+ARHGAP8chr2245241148+0.090124620.9098754
ENST00000006251ENST00000336963PRR5chr2245110550+ARHGAP8chr2245241148+0.0252681280.9747319
ENST00000006251ENST00000356099PRR5chr2245110550+ARHGAP8chr2245241148+0.090124620.9098754
ENST00000403581ENST00000517296PRR5chr2245110550+ARHGAP8chr2245241148+0.0681790040.93182105
ENST00000403581ENST00000389773PRR5chr2245110550+ARHGAP8chr2245241148+0.062086170.9379139
ENST00000403581ENST00000389774PRR5chr2245110550+ARHGAP8chr2245241148+0.062086170.9379139
ENST00000403581ENST00000336963PRR5chr2245110550+ARHGAP8chr2245241148+0.0271410030.97285897
ENST00000403581ENST00000356099PRR5chr2245110550+ARHGAP8chr2245241148+0.062086170.9379139
ENST00000336985ENST00000517296PRR5chr2245110550+ARHGAP8chr2245241148+0.036384810.96361524
ENST00000336985ENST00000389773PRR5chr2245110550+ARHGAP8chr2245241148+0.033538610.96646136
ENST00000336985ENST00000389774PRR5chr2245110550+ARHGAP8chr2245241148+0.033538610.96646136
ENST00000336985ENST00000336963PRR5chr2245110550+ARHGAP8chr2245241148+0.0156447440.98435533
ENST00000336985ENST00000356099PRR5chr2245110550+ARHGAP8chr2245241148+0.033538610.96646136

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Fusion Genomic Features for PRR5-ARHGAP8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PRR5chr2245122514+ARHGAP8chr2245182336+0.0016065540.9983935
PRR5chr2245122514+ARHGAP8chr2245241148+4.41E-050.9999559
PRR5chr2245110551+ARHGAP8chr2245241148+2.19E-101
PRR5chr2245122514+ARHGAP8chr2245182336+0.0016065540.9983935
PRR5chr2245122514+ARHGAP8chr2245241148+4.41E-050.9999559
PRR5chr2245110551+ARHGAP8chr2245241148+2.19E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PRR5-ARHGAP8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:45110550/chr22:45241148)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARHGAP8

P85298

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRR5chr22:45110550chr22:45241148ENST00000006251+3924_2762380.0Compositional biasNote=Poly-Ala
HgenePRR5chr22:45110550chr22:45241148ENST00000336985+2824_2771389.0Compositional biasNote=Poly-Ala
HgenePRR5chr22:45110550chr22:45241148ENST00000403581+41024_2794412.0Compositional biasNote=Poly-Ala
HgenePRR5chr22:45122514chr22:45182337ENST00000006251+5924_2798380.0Compositional biasNote=Poly-Ala
HgenePRR5chr22:45122514chr22:45182337ENST00000336985+4824_27107389.0Compositional biasNote=Poly-Ala
HgenePRR5chr22:45122514chr22:45182337ENST00000403581+61024_27130412.0Compositional biasNote=Poly-Ala
TgeneARHGAP8chr22:45110550chr22:45241148ENST00000356099612226_412198434.0DomainRho-GAP
TgeneARHGAP8chr22:45122514chr22:45182337ENST0000035609901213_1990434.0DomainCRAL-TRIO
TgeneARHGAP8chr22:45122514chr22:45182337ENST00000356099012226_4120434.0DomainRho-GAP
TgeneARHGAP8chr22:45122514chr22:45182337ENST0000038977401313_1990465.0DomainCRAL-TRIO
TgeneARHGAP8chr22:45122514chr22:45182337ENST00000389774013226_4120465.0DomainRho-GAP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARHGAP8chr22:45110550chr22:45241148ENST0000035609961213_199198434.0DomainCRAL-TRIO
TgeneARHGAP8chr22:45110550chr22:45241148ENST0000038977471313_199229465.0DomainCRAL-TRIO
TgeneARHGAP8chr22:45110550chr22:45241148ENST00000389774713226_412229465.0DomainRho-GAP


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Fusion Gene Sequence for PRR5-ARHGAP8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>69171_69171_1_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000006251_ARHGAP8_chr22_45241148_ENST00000336963_length(transcript)=1174nt_BP=382nt
ATTCGGCTGCCCCCAAGGCCAGGCATCCAGTGTGCTTAGTGCTGAGCAGGGTTTCAGAGCTCACCCCCAGGAGGGTGCAGACCTCAGCCA
AGGTCGCAGAGCAGAGGAGACCCGTGGGCTGGGATTCCACCTGTGCCCACCCTGGCAGCATCCCACCTCCTGAGTCCTCTCGGCACCCAG
CAAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGC
GCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCT
TCAGCCTCAACGAGGGCGTCCGCCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAG
AGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAGGCTCTACAACCAAGGGAAGC
CCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCTGCCCCAGCCGCTTCTGACCT
TCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTCCCGGGAGAGCATCTTCAACAAAATGAACAGCTCTAACCTGGCCTGTGTCTTC
GGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAACATGTTCACTGAACTGCTGATCGAGTAC
TATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATGGGAACAGGGGAGCAGGGCAGCCCCTTTGCAGGAG
GCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCCCCTGATGGCAGCCAGAAGACGTCTCTAGTGTTGC
GAACACTCTGTATATTTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTTTGTAAACTTGGCATCTGTAAAAATAACCAGCCAT
TAGATGAATTCAGAACCTTCTAATGAAAACTCCATGCCTCTGGTCCTTGGACTCTTGTCCATGGTTCCTGAGCTGTGGACCGGGATAGAA
TAAT

>69171_69171_1_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000006251_ARHGAP8_chr22_45241148_ENST00000336963_length(amino acids)=220AA_BP=1
MSRVSELTPRRVQTSAKVAEQRRPVGWDSTCAHPGSIPPPESSRHPARLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHN
GVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPA
VILKTFLRELPQPLLTFQAYEQILGITCVPGEHLQQNEQL

--------------------------------------------------------------
>69171_69171_2_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000006251_ARHGAP8_chr22_45241148_ENST00000356099_length(transcript)=1277nt_BP=382nt
ATTCGGCTGCCCCCAAGGCCAGGCATCCAGTGTGCTTAGTGCTGAGCAGGGTTTCAGAGCTCACCCCCAGGAGGGTGCAGACCTCAGCCA
AGGTCGCAGAGCAGAGGAGACCCGTGGGCTGGGATTCCACCTGTGCCCACCCTGGCAGCATCCCACCTCCTGAGTCCTCTCGGCACCCAG
CAAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGC
GCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCT
TCAGCCTCAACGAGGGCGTCCGCCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAG
AGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAGGCTCTACAACCAAGGGAAGC
CCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCTGCCCCAGCCGCTTCTGACCT
TCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCAGATCTTACGGAGCCTCCCAG
AGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAACAAAATGAACAGCTCTAACC
TGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAACATGTTCACTGAAC
TGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATGGGAACAGGGGAGCAGGGCAG
CCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCCCCTGATGGCAGCCAGAAGAC
GTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTTTGTAAACTTGGCATCTGTAA
AAATAACCAGCCATTAGATGAATTCAGAACCTTCTAATGAAAACTCCATGCCTCTGGTCCTTGGACTCTTGTCCATGGTTCCTGAGCTGT
GGACCGGGATAGAATAA

>69171_69171_2_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000006251_ARHGAP8_chr22_45241148_ENST00000356099_length(amino acids)=348AA_BP=1
MSRVSELTPRRVQTSAKVAEQRRPVGWDSTCAHPGSIPPPESSRHPARLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHN
GVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPA
VILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQ
GVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL

--------------------------------------------------------------
>69171_69171_3_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000006251_ARHGAP8_chr22_45241148_ENST00000389773_length(transcript)=1277nt_BP=382nt
ATTCGGCTGCCCCCAAGGCCAGGCATCCAGTGTGCTTAGTGCTGAGCAGGGTTTCAGAGCTCACCCCCAGGAGGGTGCAGACCTCAGCCA
AGGTCGCAGAGCAGAGGAGACCCGTGGGCTGGGATTCCACCTGTGCCCACCCTGGCAGCATCCCACCTCCTGAGTCCTCTCGGCACCCAG
CAAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGC
GCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCT
TCAGCCTCAACGAGGGCGTCCGCCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAG
AGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAGGCTCTACAACCAAGGGAAGC
CCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCTGCCCCAGCCGCTTCTGACCT
TCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCAGATCTTACGGAGCCTCCCAG
AGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAACAAAATGAACAGCTCTAACC
TGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAACATGTTCACTGAAC
TGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATGGGAACAGGGGAGCAGGGCAG
CCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCCCCTGATGGCAGCCAGAAGAC
GTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTTTGTAAACTTGGCATCTGTAA
AAATAACCAGCCATTAGATGAATTCAGAACCTTCTAATGAAAACTCCATGCCTCTGGTCCTTGGACTCTTGTCCATGGTTCCTGAGCTGT
GGACCGGGATAGAATAA

>69171_69171_3_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000006251_ARHGAP8_chr22_45241148_ENST00000389773_length(amino acids)=348AA_BP=1
MSRVSELTPRRVQTSAKVAEQRRPVGWDSTCAHPGSIPPPESSRHPARLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHN
GVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPA
VILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQ
GVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL

--------------------------------------------------------------
>69171_69171_4_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000006251_ARHGAP8_chr22_45241148_ENST00000389774_length(transcript)=1277nt_BP=382nt
ATTCGGCTGCCCCCAAGGCCAGGCATCCAGTGTGCTTAGTGCTGAGCAGGGTTTCAGAGCTCACCCCCAGGAGGGTGCAGACCTCAGCCA
AGGTCGCAGAGCAGAGGAGACCCGTGGGCTGGGATTCCACCTGTGCCCACCCTGGCAGCATCCCACCTCCTGAGTCCTCTCGGCACCCAG
CAAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGC
GCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCT
TCAGCCTCAACGAGGGCGTCCGCCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAG
AGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAGGCTCTACAACCAAGGGAAGC
CCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCTGCCCCAGCCGCTTCTGACCT
TCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCAGATCTTACGGAGCCTCCCAG
AGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAACAAAATGAACAGCTCTAACC
TGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAACATGTTCACTGAAC
TGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATGGGAACAGGGGAGCAGGGCAG
CCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCCCCTGATGGCAGCCAGAAGAC
GTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTTTGTAAACTTGGCATCTGTAA
AAATAACCAGCCATTAGATGAATTCAGAACCTTCTAATGAAAACTCCATGCCTCTGGTCCTTGGACTCTTGTCCATGGTTCCTGAGCTGT
GGACCGGGATAGAATAA

>69171_69171_4_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000006251_ARHGAP8_chr22_45241148_ENST00000389774_length(amino acids)=348AA_BP=1
MSRVSELTPRRVQTSAKVAEQRRPVGWDSTCAHPGSIPPPESSRHPARLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHN
GVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPA
VILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQ
GVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL

--------------------------------------------------------------
>69171_69171_5_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000006251_ARHGAP8_chr22_45241148_ENST00000517296_length(transcript)=1199nt_BP=382nt
ATTCGGCTGCCCCCAAGGCCAGGCATCCAGTGTGCTTAGTGCTGAGCAGGGTTTCAGAGCTCACCCCCAGGAGGGTGCAGACCTCAGCCA
AGGTCGCAGAGCAGAGGAGACCCGTGGGCTGGGATTCCACCTGTGCCCACCCTGGCAGCATCCCACCTCCTGAGTCCTCTCGGCACCCAG
CAAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGC
GCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCT
TCAGCCTCAACGAGGGCGTCCGCCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAG
AGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAGGCTCTACAACCAAGGGAAGC
CCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCTGCCCCAGCCGCTTCTGACCT
TCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCAGATCTTACGGAGCCTCCCAG
AGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAACAAAATGAACAGCTCTAACC
TGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAACATGTTCACTGAAC
TGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATGGGAACAGGGGAGCAGGGCAG
CCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCCCCTGATGGCAGCCAGAAGAC
GTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTTTGTAAACTTGGCATCTGTAA
AAATAACCAGCCATTAGATGAATTCAGAA

>69171_69171_5_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000006251_ARHGAP8_chr22_45241148_ENST00000517296_length(amino acids)=348AA_BP=1
MSRVSELTPRRVQTSAKVAEQRRPVGWDSTCAHPGSIPPPESSRHPARLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHN
GVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPA
VILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQ
GVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL

--------------------------------------------------------------
>69171_69171_6_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000336985_ARHGAP8_chr22_45241148_ENST00000336963_length(transcript)=1284nt_BP=492nt
GCCCCCGGCCTCCGTTTGCGCCGGGTCTGTGCTGGCCGCGCGCCTGGCGCTCCACGCTGAGCCTCTCCGTGCAATGATTAACCCGGCGGG
GCGGCCGGCGCGGGACCCGAGACGGAGGCGCGGGGCCGGGGCGGGACCCCGCAGGACCGCTCGGCTTCCTGCTCTCGCCGGAGTTTCCGC
GTAGAGGGCGCATCGCCGGCCCGGGGCCCTTGGTGCGGCGTGGCGCAGGGCGCGGCGTGGGGCGCGCGTGGGCGCGGCGCAGGCGGCCCG
GGTCACCATGAGGACTCTCCGCAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGA
CGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGG
GCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGCCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTT
CACAGTGACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAG
GCTCTACAACCAAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCT
GCCCCAGCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTCCCGGGAGAGCATCTTCAACAAAATGAACAGCT
CTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAACATGTTCA
CTGAACTGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATGGGAACAGGGGAGCA
GGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCCCCTGATGGCAGCCA
GAAGACGTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTTTGTAAACTTGGCAT
CTGTAAAAATAACCAGCCATTAGATGAATTCAGAACCTTCTAATGAAAACTCCATGCCTCTGGTCCTTGGACTCTTGTCCATGGTTCCTG
AGCTGTGGACCGGGATAGAATAAT

>69171_69171_6_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000336985_ARHGAP8_chr22_45241148_ENST00000336963_length(amino acids)=178AA_BP=0
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTV
TYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVPGEHLQQNEQL

--------------------------------------------------------------
>69171_69171_7_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000336985_ARHGAP8_chr22_45241148_ENST00000356099_length(transcript)=1387nt_BP=492nt
GCCCCCGGCCTCCGTTTGCGCCGGGTCTGTGCTGGCCGCGCGCCTGGCGCTCCACGCTGAGCCTCTCCGTGCAATGATTAACCCGGCGGG
GCGGCCGGCGCGGGACCCGAGACGGAGGCGCGGGGCCGGGGCGGGACCCCGCAGGACCGCTCGGCTTCCTGCTCTCGCCGGAGTTTCCGC
GTAGAGGGCGCATCGCCGGCCCGGGGCCCTTGGTGCGGCGTGGCGCAGGGCGCGGCGTGGGGCGCGCGTGGGCGCGGCGCAGGCGGCCCG
GGTCACCATGAGGACTCTCCGCAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGA
CGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGG
GCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGCCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTT
CACAGTGACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAG
GCTCTACAACCAAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCT
GCCCCAGCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCA
GATCTTACGGAGCCTCCCAGAGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAA
CAAAATGAACAGCTCTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCC
CCTGAACATGTTCACTGAACTGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATG
GGAACAGGGGAGCAGGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCC
CCTGATGGCAGCCAGAAGACGTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTT
TGTAAACTTGGCATCTGTAAAAATAACCAGCCATTAGATGAATTCAGAACCTTCTAATGAAAACTCCATGCCTCTGGTCCTTGGACTCTT
GTCCATGGTTCCTGAGCTGTGGACCGGGATAGAATAA

>69171_69171_7_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000336985_ARHGAP8_chr22_45241148_ENST00000356099_length(amino acids)=306AA_BP=0
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTV
TYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQIL
RSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQ
GSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL

--------------------------------------------------------------
>69171_69171_8_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000336985_ARHGAP8_chr22_45241148_ENST00000389773_length(transcript)=1387nt_BP=492nt
GCCCCCGGCCTCCGTTTGCGCCGGGTCTGTGCTGGCCGCGCGCCTGGCGCTCCACGCTGAGCCTCTCCGTGCAATGATTAACCCGGCGGG
GCGGCCGGCGCGGGACCCGAGACGGAGGCGCGGGGCCGGGGCGGGACCCCGCAGGACCGCTCGGCTTCCTGCTCTCGCCGGAGTTTCCGC
GTAGAGGGCGCATCGCCGGCCCGGGGCCCTTGGTGCGGCGTGGCGCAGGGCGCGGCGTGGGGCGCGCGTGGGCGCGGCGCAGGCGGCCCG
GGTCACCATGAGGACTCTCCGCAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGA
CGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGG
GCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGCCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTT
CACAGTGACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAG
GCTCTACAACCAAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCT
GCCCCAGCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCA
GATCTTACGGAGCCTCCCAGAGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAA
CAAAATGAACAGCTCTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCC
CCTGAACATGTTCACTGAACTGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATG
GGAACAGGGGAGCAGGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCC
CCTGATGGCAGCCAGAAGACGTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTT
TGTAAACTTGGCATCTGTAAAAATAACCAGCCATTAGATGAATTCAGAACCTTCTAATGAAAACTCCATGCCTCTGGTCCTTGGACTCTT
GTCCATGGTTCCTGAGCTGTGGACCGGGATAGAATAA

>69171_69171_8_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000336985_ARHGAP8_chr22_45241148_ENST00000389773_length(amino acids)=306AA_BP=0
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTV
TYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQIL
RSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQ
GSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL

--------------------------------------------------------------
>69171_69171_9_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000336985_ARHGAP8_chr22_45241148_ENST00000389774_length(transcript)=1387nt_BP=492nt
GCCCCCGGCCTCCGTTTGCGCCGGGTCTGTGCTGGCCGCGCGCCTGGCGCTCCACGCTGAGCCTCTCCGTGCAATGATTAACCCGGCGGG
GCGGCCGGCGCGGGACCCGAGACGGAGGCGCGGGGCCGGGGCGGGACCCCGCAGGACCGCTCGGCTTCCTGCTCTCGCCGGAGTTTCCGC
GTAGAGGGCGCATCGCCGGCCCGGGGCCCTTGGTGCGGCGTGGCGCAGGGCGCGGCGTGGGGCGCGCGTGGGCGCGGCGCAGGCGGCCCG
GGTCACCATGAGGACTCTCCGCAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGA
CGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGG
GCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGCCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTT
CACAGTGACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAG
GCTCTACAACCAAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCT
GCCCCAGCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCA
GATCTTACGGAGCCTCCCAGAGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAA
CAAAATGAACAGCTCTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCC
CCTGAACATGTTCACTGAACTGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATG
GGAACAGGGGAGCAGGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCC
CCTGATGGCAGCCAGAAGACGTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTT
TGTAAACTTGGCATCTGTAAAAATAACCAGCCATTAGATGAATTCAGAACCTTCTAATGAAAACTCCATGCCTCTGGTCCTTGGACTCTT
GTCCATGGTTCCTGAGCTGTGGACCGGGATAGAATAA

>69171_69171_9_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000336985_ARHGAP8_chr22_45241148_ENST00000389774_length(amino acids)=306AA_BP=0
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTV
TYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQIL
RSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQ
GSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL

--------------------------------------------------------------
>69171_69171_10_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000336985_ARHGAP8_chr22_45241148_ENST00000517296_length(transcript)=1309nt_BP=492nt
GCCCCCGGCCTCCGTTTGCGCCGGGTCTGTGCTGGCCGCGCGCCTGGCGCTCCACGCTGAGCCTCTCCGTGCAATGATTAACCCGGCGGG
GCGGCCGGCGCGGGACCCGAGACGGAGGCGCGGGGCCGGGGCGGGACCCCGCAGGACCGCTCGGCTTCCTGCTCTCGCCGGAGTTTCCGC
GTAGAGGGCGCATCGCCGGCCCGGGGCCCTTGGTGCGGCGTGGCGCAGGGCGCGGCGTGGGGCGCGCGTGGGCGCGGCGCAGGCGGCCCG
GGTCACCATGAGGACTCTCCGCAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGA
CGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGG
GCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGCCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTT
CACAGTGACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAG
GCTCTACAACCAAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCT
GCCCCAGCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCA
GATCTTACGGAGCCTCCCAGAGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAA
CAAAATGAACAGCTCTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCC
CCTGAACATGTTCACTGAACTGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATG
GGAACAGGGGAGCAGGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCC
CCTGATGGCAGCCAGAAGACGTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTT
TGTAAACTTGGCATCTGTAAAAATAACCAGCCATTAGATGAATTCAGAA

>69171_69171_10_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000336985_ARHGAP8_chr22_45241148_ENST00000517296_length(amino acids)=306AA_BP=0
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTV
TYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQIL
RSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQ
GSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL

--------------------------------------------------------------
>69171_69171_11_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000403581_ARHGAP8_chr22_45241148_ENST00000336963_length(transcript)=1685nt_BP=893nt
AGTGTGCTTAGTGCTGAGCAGGGTTTCAGAGCTCACCCCCAGGAGGGTGCAGACCTCAGCCAAGGTCGCAGAGCAGAGGAGACCCGTGGG
CTGGGATTCCACCTGTGCCCACCCTGGCAGCATCCCACCTCCTGAGTCCTCTCGGCACCCAGCAAGAGTCCCTTCAGTGACTTCGAGCGT
GCATTGAGAGCCCAGTAACACTGGGGGGCAACTGCCACAAAGACACAGCCTCAGCCAGGCGCAGTGACTCATGCCTGTAATCCCAGCACC
TTGGGAGGCCAAGGCTTGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCGGACCAACATGGAGAAACCCCATCTCTACTAAAAATAC
AAAAAAATTAGCTAGGCATTGTGGCGCATGCCTGTAATCCCGGCTACTCGGGAGGCTGAGGGAGGAGAAGCACTTGAACCCAGGAGGCGC
GGTTGCAGTGAGCCGAGATCGCCCCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCATCTCAAAATAATAATAATAACAATAATA
GTAAGACTCAGCCTCCCCGCTCTGGGACACTCAGTCTGATGGGGCAGGCTGGTCAGAAGACATAGAGCCATGGTGTGTTTGGAACTTTCA
CAGAGGGAAGCCTGGGGCTCGGGAAGCCCGGAAAAGATGCCGGCGCAGCCTGAGGGCTTGTACAGGTTGAAGTTCATGAGTTCGCCCAGC
CTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAAC
AGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGCCTCAAA
GACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTC
CGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAGGCTCTACAACCAAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATT
CACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCTGCCCCAGCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATC
ACCTGTGTCCCGGGAGAGCATCTTCAACAAAATGAACAGCTCTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGG
GGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAACATGTTCACTGAACTGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGC
ACCTGGGGAGCACGGCCTGGCACCATGGGAACAGGGGAGCAGGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCT
CACCAAGCCTACCCTACCTCCGAGTCCCCTGATGGCAGCCAGAAGACGTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCC
CACACCTGTCTGTGCACTTGTATGTTTTGTAAACTTGGCATCTGTAAAAATAACCAGCCATTAGATGAATTCAGAACCTTCTAATGAAAA
CTCCATGCCTCTGGTCCTTGGACTCTTGTCCATGGTTCCTGAGCTGTGGACCGGGATAGAATAAT

>69171_69171_11_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000403581_ARHGAP8_chr22_45241148_ENST00000336963_length(amino acids)=222AA_BP=0
MFRGTRALREETPWDGQIKFSPKTQARLELFILLKMLSRDTGDPENLLVGLEGQKRLGQLSQEGLQDHGRDVNVPVVVKVHGLPLVVEPL
DLADGLHAGGSPEQALGAQAFLSQVRHCEPQHRGDEFALIFVFEADALVEAEELLVGQPLALEDGDHPVVDAVPGGVGAGPALLRAPLVR
GGGRLSLAQVTEAGRTHELQPVQALRLRRHLFRASRAPGFPL

--------------------------------------------------------------
>69171_69171_12_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000403581_ARHGAP8_chr22_45241148_ENST00000356099_length(transcript)=1788nt_BP=893nt
AGTGTGCTTAGTGCTGAGCAGGGTTTCAGAGCTCACCCCCAGGAGGGTGCAGACCTCAGCCAAGGTCGCAGAGCAGAGGAGACCCGTGGG
CTGGGATTCCACCTGTGCCCACCCTGGCAGCATCCCACCTCCTGAGTCCTCTCGGCACCCAGCAAGAGTCCCTTCAGTGACTTCGAGCGT
GCATTGAGAGCCCAGTAACACTGGGGGGCAACTGCCACAAAGACACAGCCTCAGCCAGGCGCAGTGACTCATGCCTGTAATCCCAGCACC
TTGGGAGGCCAAGGCTTGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCGGACCAACATGGAGAAACCCCATCTCTACTAAAAATAC
AAAAAAATTAGCTAGGCATTGTGGCGCATGCCTGTAATCCCGGCTACTCGGGAGGCTGAGGGAGGAGAAGCACTTGAACCCAGGAGGCGC
GGTTGCAGTGAGCCGAGATCGCCCCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCATCTCAAAATAATAATAATAACAATAATA
GTAAGACTCAGCCTCCCCGCTCTGGGACACTCAGTCTGATGGGGCAGGCTGGTCAGAAGACATAGAGCCATGGTGTGTTTGGAACTTTCA
CAGAGGGAAGCCTGGGGCTCGGGAAGCCCGGAAAAGATGCCGGCGCAGCCTGAGGGCTTGTACAGGTTGAAGTTCATGAGTTCGCCCAGC
CTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAAC
AGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGCCTCAAA
GACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTC
CGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAGGCTCTACAACCAAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATT
CACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCTGCCCCAGCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATC
ACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCAGATCTTACGGAGCCTCCCAGAGCACAACTACGTCGTCCTCCGCTACCTC
ATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAACAAAATGAACAGCTCTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATC
TGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAACATGTTCACTGAACTGCTGATCGAGTACTATGAAAAGATCTTC
AGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATGGGAACAGGGGAGCAGGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACA
CAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCCCCTGATGGCAGCCAGAAGACGTCTCTAGTGTTGCGAACACTCTGTATAT
TTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTTTGTAAACTTGGCATCTGTAAAAATAACCAGCCATTAGATGAATTCAGAA
CCTTCTAATGAAAACTCCATGCCTCTGGTCCTTGGACTCTTGTCCATGGTTCCTGAGCTGTGGACCGGGATAGAATAA

>69171_69171_12_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000403581_ARHGAP8_chr22_45241148_ENST00000356099_length(amino acids)=336AA_BP=1
MVRRHRAMVCLELSQREAWGSGSPEKMPAQPEGLYRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLP
DQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQ
PLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLN
MFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL

--------------------------------------------------------------
>69171_69171_13_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000403581_ARHGAP8_chr22_45241148_ENST00000389773_length(transcript)=1788nt_BP=893nt
AGTGTGCTTAGTGCTGAGCAGGGTTTCAGAGCTCACCCCCAGGAGGGTGCAGACCTCAGCCAAGGTCGCAGAGCAGAGGAGACCCGTGGG
CTGGGATTCCACCTGTGCCCACCCTGGCAGCATCCCACCTCCTGAGTCCTCTCGGCACCCAGCAAGAGTCCCTTCAGTGACTTCGAGCGT
GCATTGAGAGCCCAGTAACACTGGGGGGCAACTGCCACAAAGACACAGCCTCAGCCAGGCGCAGTGACTCATGCCTGTAATCCCAGCACC
TTGGGAGGCCAAGGCTTGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCGGACCAACATGGAGAAACCCCATCTCTACTAAAAATAC
AAAAAAATTAGCTAGGCATTGTGGCGCATGCCTGTAATCCCGGCTACTCGGGAGGCTGAGGGAGGAGAAGCACTTGAACCCAGGAGGCGC
GGTTGCAGTGAGCCGAGATCGCCCCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCATCTCAAAATAATAATAATAACAATAATA
GTAAGACTCAGCCTCCCCGCTCTGGGACACTCAGTCTGATGGGGCAGGCTGGTCAGAAGACATAGAGCCATGGTGTGTTTGGAACTTTCA
CAGAGGGAAGCCTGGGGCTCGGGAAGCCCGGAAAAGATGCCGGCGCAGCCTGAGGGCTTGTACAGGTTGAAGTTCATGAGTTCGCCCAGC
CTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAAC
AGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGCCTCAAA
GACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTC
CGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAGGCTCTACAACCAAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATT
CACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCTGCCCCAGCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATC
ACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCAGATCTTACGGAGCCTCCCAGAGCACAACTACGTCGTCCTCCGCTACCTC
ATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAACAAAATGAACAGCTCTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATC
TGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAACATGTTCACTGAACTGCTGATCGAGTACTATGAAAAGATCTTC
AGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATGGGAACAGGGGAGCAGGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACA
CAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCCCCTGATGGCAGCCAGAAGACGTCTCTAGTGTTGCGAACACTCTGTATAT
TTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTTTGTAAACTTGGCATCTGTAAAAATAACCAGCCATTAGATGAATTCAGAA
CCTTCTAATGAAAACTCCATGCCTCTGGTCCTTGGACTCTTGTCCATGGTTCCTGAGCTGTGGACCGGGATAGAATAA

>69171_69171_13_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000403581_ARHGAP8_chr22_45241148_ENST00000389773_length(amino acids)=336AA_BP=1
MVRRHRAMVCLELSQREAWGSGSPEKMPAQPEGLYRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLP
DQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQ
PLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLN
MFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL

--------------------------------------------------------------
>69171_69171_14_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000403581_ARHGAP8_chr22_45241148_ENST00000389774_length(transcript)=1788nt_BP=893nt
AGTGTGCTTAGTGCTGAGCAGGGTTTCAGAGCTCACCCCCAGGAGGGTGCAGACCTCAGCCAAGGTCGCAGAGCAGAGGAGACCCGTGGG
CTGGGATTCCACCTGTGCCCACCCTGGCAGCATCCCACCTCCTGAGTCCTCTCGGCACCCAGCAAGAGTCCCTTCAGTGACTTCGAGCGT
GCATTGAGAGCCCAGTAACACTGGGGGGCAACTGCCACAAAGACACAGCCTCAGCCAGGCGCAGTGACTCATGCCTGTAATCCCAGCACC
TTGGGAGGCCAAGGCTTGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCGGACCAACATGGAGAAACCCCATCTCTACTAAAAATAC
AAAAAAATTAGCTAGGCATTGTGGCGCATGCCTGTAATCCCGGCTACTCGGGAGGCTGAGGGAGGAGAAGCACTTGAACCCAGGAGGCGC
GGTTGCAGTGAGCCGAGATCGCCCCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCATCTCAAAATAATAATAATAACAATAATA
GTAAGACTCAGCCTCCCCGCTCTGGGACACTCAGTCTGATGGGGCAGGCTGGTCAGAAGACATAGAGCCATGGTGTGTTTGGAACTTTCA
CAGAGGGAAGCCTGGGGCTCGGGAAGCCCGGAAAAGATGCCGGCGCAGCCTGAGGGCTTGTACAGGTTGAAGTTCATGAGTTCGCCCAGC
CTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAAC
AGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGCCTCAAA
GACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTC
CGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAGGCTCTACAACCAAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATT
CACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCTGCCCCAGCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATC
ACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCAGATCTTACGGAGCCTCCCAGAGCACAACTACGTCGTCCTCCGCTACCTC
ATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAACAAAATGAACAGCTCTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATC
TGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAACATGTTCACTGAACTGCTGATCGAGTACTATGAAAAGATCTTC
AGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATGGGAACAGGGGAGCAGGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACA
CAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCCCCTGATGGCAGCCAGAAGACGTCTCTAGTGTTGCGAACACTCTGTATAT
TTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTTTGTAAACTTGGCATCTGTAAAAATAACCAGCCATTAGATGAATTCAGAA
CCTTCTAATGAAAACTCCATGCCTCTGGTCCTTGGACTCTTGTCCATGGTTCCTGAGCTGTGGACCGGGATAGAATAA

>69171_69171_14_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000403581_ARHGAP8_chr22_45241148_ENST00000389774_length(amino acids)=336AA_BP=1
MVRRHRAMVCLELSQREAWGSGSPEKMPAQPEGLYRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLP
DQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQ
PLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLN
MFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL

--------------------------------------------------------------
>69171_69171_15_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000403581_ARHGAP8_chr22_45241148_ENST00000517296_length(transcript)=1710nt_BP=893nt
AGTGTGCTTAGTGCTGAGCAGGGTTTCAGAGCTCACCCCCAGGAGGGTGCAGACCTCAGCCAAGGTCGCAGAGCAGAGGAGACCCGTGGG
CTGGGATTCCACCTGTGCCCACCCTGGCAGCATCCCACCTCCTGAGTCCTCTCGGCACCCAGCAAGAGTCCCTTCAGTGACTTCGAGCGT
GCATTGAGAGCCCAGTAACACTGGGGGGCAACTGCCACAAAGACACAGCCTCAGCCAGGCGCAGTGACTCATGCCTGTAATCCCAGCACC
TTGGGAGGCCAAGGCTTGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCGGACCAACATGGAGAAACCCCATCTCTACTAAAAATAC
AAAAAAATTAGCTAGGCATTGTGGCGCATGCCTGTAATCCCGGCTACTCGGGAGGCTGAGGGAGGAGAAGCACTTGAACCCAGGAGGCGC
GGTTGCAGTGAGCCGAGATCGCCCCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCATCTCAAAATAATAATAATAACAATAATA
GTAAGACTCAGCCTCCCCGCTCTGGGACACTCAGTCTGATGGGGCAGGCTGGTCAGAAGACATAGAGCCATGGTGTGTTTGGAACTTTCA
CAGAGGGAAGCCTGGGGCTCGGGAAGCCCGGAAAAGATGCCGGCGCAGCCTGAGGGCTTGTACAGGTTGAAGTTCATGAGTTCGCCCAGC
CTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAAC
AGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGCCTCAAA
GACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTC
CGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAGGCTCTACAACCAAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATT
CACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCTGCCCCAGCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATC
ACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCAGATCTTACGGAGCCTCCCAGAGCACAACTACGTCGTCCTCCGCTACCTC
ATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAACAAAATGAACAGCTCTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATC
TGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAACATGTTCACTGAACTGCTGATCGAGTACTATGAAAAGATCTTC
AGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATGGGAACAGGGGAGCAGGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACA
CAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCCCCTGATGGCAGCCAGAAGACGTCTCTAGTGTTGCGAACACTCTGTATAT
TTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTTTGTAAACTTGGCATCTGTAAAAATAACCAGCCATTAGATGAATTCAGAA


>69171_69171_15_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000403581_ARHGAP8_chr22_45241148_ENST00000517296_length(amino acids)=336AA_BP=1
MVRRHRAMVCLELSQREAWGSGSPEKMPAQPEGLYRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLP
DQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQ
PLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLN
MFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PRR5-ARHGAP8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgenePRR5chr22:45110550chr22:45241148ENST00000403581+41010_9594.66666666666667412.0RICTOR
HgenePRR5chr22:45122514chr22:45182337ENST00000006251+5910_9598.33333333333333380.0RICTOR
HgenePRR5chr22:45122514chr22:45182337ENST00000336985+4810_95107.33333333333333389.0RICTOR
HgenePRR5chr22:45122514chr22:45182337ENST00000403581+61010_95130.33333333333334412.0RICTOR


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePRR5chr22:45110550chr22:45241148ENST00000006251+3910_9562.666666666666664380.0RICTOR
HgenePRR5chr22:45110550chr22:45241148ENST00000006251+39188_21862.666666666666664380.0RICTOR
HgenePRR5chr22:45110550chr22:45241148ENST00000336985+2810_9571.66666666666667389.0RICTOR
HgenePRR5chr22:45110550chr22:45241148ENST00000336985+28188_21871.66666666666667389.0RICTOR
HgenePRR5chr22:45110550chr22:45241148ENST00000403581+410188_21894.66666666666667412.0RICTOR
HgenePRR5chr22:45122514chr22:45182337ENST00000006251+59188_21898.33333333333333380.0RICTOR
HgenePRR5chr22:45122514chr22:45182337ENST00000336985+48188_218107.33333333333333389.0RICTOR
HgenePRR5chr22:45122514chr22:45182337ENST00000403581+610188_218130.33333333333334412.0RICTOR


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRR5-ARHGAP8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRR5-ARHGAP8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource