|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FLVCR2-BATF (FusionGDB2 ID:HG55640TG10538) |
Fusion Gene Summary for FLVCR2-BATF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FLVCR2-BATF | Fusion gene ID: hg55640tg10538 | Hgene | Tgene | Gene symbol | FLVCR2 | BATF | Gene ID | 55640 | 10538 |
| Gene name | FLVCR heme transporter 2 | basic leucine zipper ATF-like transcription factor | |
| Synonyms | C14orf58|CCT|EPV|FLVCRL14q|MFSD7C|PVHH|SLC49A2 | B-ATF|BATF1|SFA-2|SFA2 | |
| Cytomap | ('FLVCR2')('BATF') 14q24.3 | 14q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | feline leukemia virus subgroup C receptor-related protein 2calcium-chelate transporterfeline leukemia virus subgroup C cellular receptor family member 2 | basic leucine zipper transcriptional factor ATF-likeB-cell-activating transcription factorSF-HT-activated gene 2 proteinactivating transcription factor Bbasic leucine zipper transcription factor, ATF-like | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q16520 | |
| Ensembl transtripts involved in fusion gene | ENST00000238667, ENST00000539311, ENST00000553587, ENST00000555027, ENST00000556241, ENST00000556856, | ||
| Fusion gene scores | * DoF score | 4 X 5 X 4=80 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/80*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: FLVCR2 [Title/Abstract] AND BATF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FLVCR2(76045984)-BATF(76012805), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | FLVCR2-BATF seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. FLVCR2-BATF seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. FLVCR2-BATF seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | ACC | TCGA-OR-A5J7-01A | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| ChimerDB4 | ACC | TCGA-OR-A5J7-01A | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
Top |
Fusion Gene ORF analysis for FLVCR2-BATF |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000238667 | ENST00000555795 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| 5CDS-3UTR | ENST00000238667 | ENST00000555795 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| 5CDS-intron | ENST00000238667 | ENST00000555504 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| 5CDS-intron | ENST00000238667 | ENST00000555504 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| Frame-shift | ENST00000238667 | ENST00000286639 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| Frame-shift | ENST00000238667 | ENST00000286639 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| intron-3CDS | ENST00000539311 | ENST00000286639 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| intron-3CDS | ENST00000539311 | ENST00000286639 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| intron-3CDS | ENST00000553587 | ENST00000286639 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| intron-3CDS | ENST00000553587 | ENST00000286639 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| intron-3CDS | ENST00000555027 | ENST00000286639 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| intron-3CDS | ENST00000555027 | ENST00000286639 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| intron-3CDS | ENST00000556241 | ENST00000286639 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| intron-3CDS | ENST00000556241 | ENST00000286639 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| intron-3CDS | ENST00000556856 | ENST00000286639 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| intron-3CDS | ENST00000556856 | ENST00000286639 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| intron-3UTR | ENST00000539311 | ENST00000555795 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| intron-3UTR | ENST00000539311 | ENST00000555795 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| intron-3UTR | ENST00000553587 | ENST00000555795 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| intron-3UTR | ENST00000553587 | ENST00000555795 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| intron-3UTR | ENST00000555027 | ENST00000555795 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| intron-3UTR | ENST00000555027 | ENST00000555795 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| intron-3UTR | ENST00000556241 | ENST00000555795 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| intron-3UTR | ENST00000556241 | ENST00000555795 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| intron-3UTR | ENST00000556856 | ENST00000555795 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| intron-3UTR | ENST00000556856 | ENST00000555795 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| intron-intron | ENST00000539311 | ENST00000555504 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| intron-intron | ENST00000539311 | ENST00000555504 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| intron-intron | ENST00000553587 | ENST00000555504 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| intron-intron | ENST00000553587 | ENST00000555504 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| intron-intron | ENST00000555027 | ENST00000555504 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| intron-intron | ENST00000555027 | ENST00000555504 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| intron-intron | ENST00000556241 | ENST00000555504 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| intron-intron | ENST00000556241 | ENST00000555504 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| intron-intron | ENST00000556856 | ENST00000555504 | FLVCR2 | chr14 | 76045983 | + | BATF | chr14 | 76012804 | + |
| intron-intron | ENST00000556856 | ENST00000555504 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for FLVCR2-BATF |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012804 | + | 1.62E-10 | 1 |
| FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012804 | + | 1.62E-10 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for FLVCR2-BATF |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:76045984/:76012805) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | BATF |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for FLVCR2-BATF |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
Top |
Fusion Gene PPI Analysis for FLVCR2-BATF |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for FLVCR2-BATF |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for FLVCR2-BATF |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FLVCR2 | C1856972 | Encephaloclastic Proliferative Vasculopathy | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Hgene | FLVCR2 | C3203738 | Fowler syndrome | 1 | ORPHANET |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies