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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASF1B-KLF1 (FusionGDB2 ID:HG55723TG10661)

Fusion Gene Summary for ASF1B-KLF1

check button Fusion gene summary
Fusion gene informationFusion gene name: ASF1B-KLF1
Fusion gene ID: hg55723tg10661
HgeneTgene
Gene symbol

ASF1B

KLF1

Gene ID

55723

10661

Gene nameanti-silencing function 1B histone chaperoneKruppel like factor 1
SynonymsCIA-IIEKLF|EKLF/KLF1
Cytomap('ASF1B')('KLF1')

19p13.12

19p13.13

Type of geneprotein-codingprotein-coding
Descriptionhistone chaperone ASF1BASF1 anti-silencing function 1 homolog BCCG1-interacting factor A-IIanti-silencing function protein 1 homolog BhAsf1hAsf1bhCIA-IIKrueppel-like factor 1erythroid Kruppel-like factorerythroid krueppel-like transcription factorerythroid-specific transcription factor EKLFtruncated Kruppel-like factor 1truncated erythroid Kruppel-like factor EKLF/KLF1
Modification date2020031320200315
UniProtAcc

Q9NVP2

.
Ensembl transtripts involved in fusion geneENST00000263382, ENST00000474890, 
ENST00000592798, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 3=27
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ASF1B [Title/Abstract] AND KLF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASF1B(14236933)-KLF1(12996626), # samples:2
Anticipated loss of major functional domain due to fusion event.ASF1B-KLF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASF1B-KLF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASF1B-KLF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ASF1B-KLF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASF1B

GO:0006335

DNA replication-dependent nucleosome assembly

14718166

HgeneASF1B

GO:0006336

DNA replication-independent nucleosome assembly

14718166

TgeneKLF1

GO:0045893

positive regulation of transcription, DNA-templated

15084587|20676099|21055716


check buttonFusion gene breakpoints across ASF1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across KLF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4DLBCTCGA-RQ-A6JB-01AASF1Bchr19

14236933

-KLF1chr19

12996626

-


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Fusion Gene ORF analysis for ASF1B-KLF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000263382ENST00000264834ASF1Bchr19

14236933

-KLF1chr19

12996626

-
In-frameENST00000474890ENST00000264834ASF1Bchr19

14236933

-KLF1chr19

12996626

-
In-frameENST00000592798ENST00000264834ASF1Bchr19

14236933

-KLF1chr19

12996626

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000263382ASF1Bchr1914236933-ENST00000264834KLF1chr1912996626-1859725149790213
ENST00000592798ASF1Bchr1914236933-ENST00000264834KLF1chr1912996626-14563221455919178
ENST00000474890ASF1Bchr1914236933-ENST00000264834KLF1chr1912996626-14773431476940178

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263382ENST00000264834ASF1Bchr1914236933-KLF1chr1912996626-0.95593480.044065196
ENST00000592798ENST00000264834ASF1Bchr1914236933-KLF1chr1912996626-0.98373890.016261129
ENST00000474890ENST00000264834ASF1Bchr1914236933-KLF1chr1912996626-0.942075970.057924014

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Fusion Genomic Features for ASF1B-KLF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ASF1B-KLF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:14236933/chr19:12996626)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASF1B

Q9NVP2

.
FUNCTION: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis. {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKLF1chr19:14236933chr19:12996626ENST00000264834031_2630363.0Compositional biasNote=Pro-rich
TgeneKLF1chr19:14236933chr19:12996626ENST000002648340361_760363.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneKLF1chr19:14236933chr19:12996626ENST000002648340371_790363.0Motif9aaTAD
TgeneKLF1chr19:14236933chr19:12996626ENST0000026483403279_3030363.0Zinc fingerC2H2-type 1
TgeneKLF1chr19:14236933chr19:12996626ENST0000026483403309_3330363.0Zinc fingerC2H2-type 2
TgeneKLF1chr19:14236933chr19:12996626ENST0000026483403339_3610363.0Zinc fingerC2H2-type 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ASF1B-KLF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7074_7074_1_ASF1B-KLF1_ASF1B_chr19_14236933_ENST00000263382_KLF1_chr19_12996626_ENST00000264834_length(transcript)=1859nt_BP=725nt
CGCTGCGCGCTGCGGGATGCATCTCCCGGAAAAGCGAGGCGAGGGGCGGGCCACGCCGGTGCGGGAACCCTCAGGATTGGCCAGAAGGAG
GCCGGCGCTGTGACTCCGTCCATTCCCGCCGTTGACATCCAAGTCGGAGACGCTGGGGATTGGTTTCCAGCGGACACGCTAAGAAGCTTG
GAGATAGTTTCGCCCTCCTCACACGCTGCGGAGAGGGAGCTCCGCTGATTGGTCCGAGGAGTCTGGGCGCGCGCCGATCGGCGCTCCAGG
ACTGGCTGAGGGGGTGCGCGCGCCGCCAGGGAGCGTTGGCGGTGATTGGCCAGAGGGCGGAGGCCGGCTATTTGAAGGCGGCGCGCGGAC
TAGGTGCGCACTTCAGTTCTCGGAGAGAAGAGGCGGGAGTGGACCTGGTCAGCCCTACCCCACTGACCCCACCGGACCCAGGCGCGGCCT
CCGCCACAGCCACAGCCCCTGCCCCTGCTGCGGCGCGGCGAGGCGAGGCGATGGCCAAGGTGTCGGTGCTGAACGTGGCGGTCCTGGAGA
ACCCGAGCCCTTTCCACAGCCCCTTCCGGTTCGAGATCAGCTTCGAGTGCAGTGAAGCCCTGGCGGACGACCTGGAGTGGAAGATCATTT
ATGTTGGCTCGGCTGAGAGTGAGGAATTTGATCAGATCCTAGACTCGGTGCTGGTGGGCCCTGTGCCAGCAGGGAGACACATGTTTGTCT
TTCAGGGGAGAAGCCATACGCCTGCACGTGGGAAGGCTGCGGCTGGAGATTCGCGCGCTCGGACGAGCTGACCCGCCACTACCGGAAACA
CACGGGGCAGCGCCCCTTCCGCTGCCAGCTCTGCCCACGTGCTTTTTCGCGCTCTGACCACCTGGCCTTGCACATGAAGCGCCACCTTTG
AGCCCTGCCCTGGCACTTGGACTCTCCTAGTGACTGGGGATGGGACAAGAAGCCTGTTTGGTGGTCTCTTCACACGGACGCGCGTGACAC
AATGCTGGGTGGTTTTCCCACGAATGGACCCTCTCCTGGACTCGCGTTCCCAAAGATCCACCCAAATATCAAACACGGACCCATAGACAG
CCCTGGGGGAGCCTCTTACGGAAAATCCGACAAGCCTTCAGCCACAGGGAGCCACACAGAGATGTCCAAACTGTCGTGCAAACCCAGTGA
GACAGACCGCCAAATAAACGGACTCAGTGGACACTCAGACCAGCTCCCAGATGGCCCTGGACAGCAGGAGAGGGTGTGGGATGAGGCTTC
CCAGAGACCCTGGGTCTAGAAAGCGGCTCCTGAAGGTCCCTTATTGTGGCTGATATTAACTGTCAATGGTTATGGGTCCTATAAAAATGC
CCCTCCCAGATAACTGCGAGCCCGGGCTCCCGACGCCTTCGTGGGCCCAGCCCTGGCTCCAGCCCCGGCCCCCGAGCCCAAGGCGCTGGC
GCTGCAACCGGTGTACCCGGGGCCCGGCGCCGGCTCCTCGGGTGGCTACTTCCCGCGGACCGGGCTTTCAGTGCCTGCGGCGTCGGGCGC
CCCCTACGGGCTACTGTCCGGGTACCCCGCGATGTACCCGGCGCCTCAGTACCAAGGGCACTTCCAGCTCTTCCGCGGGCTCCAGGGACC
CGCGCCCGGTCCCGCCACGTCCCCCTCCTTCCTGAGTTGTTTGGGACCCGGGACGGTGGGCACTGGACTCGGGGGGACTGCAGAGGATCC
AGGTGTGATAGCCGAGACCGCGCCATCCAAGCGAGGCCGACGTTCGTGGGCGCGCAAGAGGCAGGCAGCGCACACGTGCGCGCACCCGGG

>7074_7074_1_ASF1B-KLF1_ASF1B_chr19_14236933_ENST00000263382_KLF1_chr19_12996626_ENST00000264834_length(amino acids)=213AA_BP=
MVSSGHAKKLGDSFALLTRCGEGAPLIGPRSLGARRSALQDWLRGCARRQGALAVIGQRAEAGYLKAARGLGAHFSSRREEAGVDLVSPT
PLTPPDPGAASATATAPAPAAARRGEAMAKVSVLNVAVLENPSPFHSPFRFEISFECSEALADDLEWKIIYVGSAESEEFDQILDSVLVG

--------------------------------------------------------------
>7074_7074_2_ASF1B-KLF1_ASF1B_chr19_14236933_ENST00000474890_KLF1_chr19_12996626_ENST00000264834_length(transcript)=1477nt_BP=343nt
GAGAGAAGAGGCGGGAGTGGACCTGGTCAGCCCTACCCCACTGACCCCACCGGACCCAGGCGCGGCCTCCGCCACAGCCACAGCCCCTGC
CCCTGCTGCGGCGCGGCGAGGCGAGGCGATGGCCAAGGTGTCGGTGCTGAACGTGGCGGTCCTGGAGAACCCGAGCCCTTTCCACAGCCC
CTTCCGGTTCGAGATCAGCTTCGAGTGCAGTGAAGCCCTGGCGGACGACCTGGAGTGGAAGATCATTTATGTTGGCTCGGCTGAGAGTGA
GGAATTTGATCAGATCCTAGACTCGGTGCTGGTGGGCCCTGTGCCAGCAGGGAGACACATGTTTGTCTTTCAGGGGAGAAGCCATACGCC
TGCACGTGGGAAGGCTGCGGCTGGAGATTCGCGCGCTCGGACGAGCTGACCCGCCACTACCGGAAACACACGGGGCAGCGCCCCTTCCGC
TGCCAGCTCTGCCCACGTGCTTTTTCGCGCTCTGACCACCTGGCCTTGCACATGAAGCGCCACCTTTGAGCCCTGCCCTGGCACTTGGAC
TCTCCTAGTGACTGGGGATGGGACAAGAAGCCTGTTTGGTGGTCTCTTCACACGGACGCGCGTGACACAATGCTGGGTGGTTTTCCCACG
AATGGACCCTCTCCTGGACTCGCGTTCCCAAAGATCCACCCAAATATCAAACACGGACCCATAGACAGCCCTGGGGGAGCCTCTTACGGA
AAATCCGACAAGCCTTCAGCCACAGGGAGCCACACAGAGATGTCCAAACTGTCGTGCAAACCCAGTGAGACAGACCGCCAAATAAACGGA
CTCAGTGGACACTCAGACCAGCTCCCAGATGGCCCTGGACAGCAGGAGAGGGTGTGGGATGAGGCTTCCCAGAGACCCTGGGTCTAGAAA
GCGGCTCCTGAAGGTCCCTTATTGTGGCTGATATTAACTGTCAATGGTTATGGGTCCTATAAAAATGCCCCTCCCAGATAACTGCGAGCC
CGGGCTCCCGACGCCTTCGTGGGCCCAGCCCTGGCTCCAGCCCCGGCCCCCGAGCCCAAGGCGCTGGCGCTGCAACCGGTGTACCCGGGG
CCCGGCGCCGGCTCCTCGGGTGGCTACTTCCCGCGGACCGGGCTTTCAGTGCCTGCGGCGTCGGGCGCCCCCTACGGGCTACTGTCCGGG
TACCCCGCGATGTACCCGGCGCCTCAGTACCAAGGGCACTTCCAGCTCTTCCGCGGGCTCCAGGGACCCGCGCCCGGTCCCGCCACGTCC
CCCTCCTTCCTGAGTTGTTTGGGACCCGGGACGGTGGGCACTGGACTCGGGGGGACTGCAGAGGATCCAGGTGTGATAGCCGAGACCGCG
CCATCCAAGCGAGGCCGACGTTCGTGGGCGCGCAAGAGGCAGGCAGCGCACACGTGCGCGCACCCGGGTTGCGGCAAGAGCTACACCAAG

>7074_7074_2_ASF1B-KLF1_ASF1B_chr19_14236933_ENST00000474890_KLF1_chr19_12996626_ENST00000264834_length(amino acids)=178AA_BP=0
LCACADAPSGGSSWCSSCRNPGARTCALPASCAPTNVGLAWMARSRLSHLDPLQSPRVQCPPSRVPNNSGRRGTWRDRARVPGARGRAGS

--------------------------------------------------------------
>7074_7074_3_ASF1B-KLF1_ASF1B_chr19_14236933_ENST00000592798_KLF1_chr19_12996626_ENST00000264834_length(transcript)=1456nt_BP=322nt
CCTGGTCAGCCCTACCCCACTGACCCCACCGGACCCAGGCGCGGCCTCCGCCACAGCCACAGCCCCTGCCCCTGCTGCGGCGCGGCGAGG
CGAGGCGATGGCCAAGGTGTCGGTGCTGAACGTGGCGGTCCTGGAGAACCCGAGCCCTTTCCACAGCCCCTTCCGGTTCGAGATCAGCTT
CGAGTGCAGTGAAGCCCTGGCGGACGACCTGGAGTGGAAGATCATTTATGTTGGCTCGGCTGAGAGTGAGGAATTTGATCAGATCCTAGA
CTCGGTGCTGGTGGGCCCTGTGCCAGCAGGGAGACACATGTTTGTCTTTCAGGGGAGAAGCCATACGCCTGCACGTGGGAAGGCTGCGGC
TGGAGATTCGCGCGCTCGGACGAGCTGACCCGCCACTACCGGAAACACACGGGGCAGCGCCCCTTCCGCTGCCAGCTCTGCCCACGTGCT
TTTTCGCGCTCTGACCACCTGGCCTTGCACATGAAGCGCCACCTTTGAGCCCTGCCCTGGCACTTGGACTCTCCTAGTGACTGGGGATGG
GACAAGAAGCCTGTTTGGTGGTCTCTTCACACGGACGCGCGTGACACAATGCTGGGTGGTTTTCCCACGAATGGACCCTCTCCTGGACTC
GCGTTCCCAAAGATCCACCCAAATATCAAACACGGACCCATAGACAGCCCTGGGGGAGCCTCTTACGGAAAATCCGACAAGCCTTCAGCC
ACAGGGAGCCACACAGAGATGTCCAAACTGTCGTGCAAACCCAGTGAGACAGACCGCCAAATAAACGGACTCAGTGGACACTCAGACCAG
CTCCCAGATGGCCCTGGACAGCAGGAGAGGGTGTGGGATGAGGCTTCCCAGAGACCCTGGGTCTAGAAAGCGGCTCCTGAAGGTCCCTTA
TTGTGGCTGATATTAACTGTCAATGGTTATGGGTCCTATAAAAATGCCCCTCCCAGATAACTGCGAGCCCGGGCTCCCGACGCCTTCGTG
GGCCCAGCCCTGGCTCCAGCCCCGGCCCCCGAGCCCAAGGCGCTGGCGCTGCAACCGGTGTACCCGGGGCCCGGCGCCGGCTCCTCGGGT
GGCTACTTCCCGCGGACCGGGCTTTCAGTGCCTGCGGCGTCGGGCGCCCCCTACGGGCTACTGTCCGGGTACCCCGCGATGTACCCGGCG
CCTCAGTACCAAGGGCACTTCCAGCTCTTCCGCGGGCTCCAGGGACCCGCGCCCGGTCCCGCCACGTCCCCCTCCTTCCTGAGTTGTTTG
GGACCCGGGACGGTGGGCACTGGACTCGGGGGGACTGCAGAGGATCCAGGTGTGATAGCCGAGACCGCGCCATCCAAGCGAGGCCGACGT
TCGTGGGCGCGCAAGAGGCAGGCAGCGCACACGTGCGCGCACCCGGGTTGCGGCAAGAGCTACACCAAGAGCTCCCACCTGAAGGCGCAT

>7074_7074_3_ASF1B-KLF1_ASF1B_chr19_14236933_ENST00000592798_KLF1_chr19_12996626_ENST00000264834_length(amino acids)=178AA_BP=0
LCACADAPSGGSSWCSSCRNPGARTCALPASCAPTNVGLAWMARSRLSHLDPLQSPRVQCPPSRVPNNSGRRGTWRDRARVPGARGRAGS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ASF1B-KLF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneASF1Bchr19:14236933chr19:12996626ENST00000263382-241_15575.0203.0CHAF1B
HgeneASF1Bchr19:14236933chr19:12996626ENST00000263382-241_15675.0203.0histone H3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASF1B-KLF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASF1B-KLF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASF1BC2239176Liver carcinoma1CTD_human
HgeneASF1BC3658266Prostatic Cancer, Castration-Resistant1CTD_human
HgeneASF1BC3658267Prostatic Neoplasms, Castration-Resistant1CTD_human
TgeneC3150926Congenital dyserythropoietic anemia type IV3GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0002876Congenital dyserythropoietic anemia2CTD_human;GENOMICS_ENGLAND
TgeneC0018939Hematological Disease1CTD_human
TgeneC0019025Hemoglobin F Disease1ORPHANET
TgeneC0020305Hydrops Fetalis1GENOMICS_ENGLAND