Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ENAH-UCHL5 (FusionGDB2 ID:HG55740TG51377)

Fusion Gene Summary for ENAH-UCHL5

check button Fusion gene summary
Fusion gene informationFusion gene name: ENAH-UCHL5
Fusion gene ID: hg55740tg51377
HgeneTgene
Gene symbol

ENAH

UCHL5

Gene ID

55740

51377

Gene nameENAH actin regulatorubiquitin C-terminal hydrolase L5
SynonymsENA|MENA|NDPP1CGI-70|INO80R|UCH-L5|UCH37
Cytomap('ENAH')('UCHL5')

1q42.12

1q31.2

Type of geneprotein-codingprotein-coding
Descriptionprotein enabled homologenabled homologmammalian enabled variant 11amammalian enabled variant panubiquitin carboxyl-terminal hydrolase isozyme L5INO80 complex subunit Rubiquitin C-terminal hydrolase UCH37ubiquitin carboxyl-terminal esterase L5ubiquitin carboxyl-terminal hydrolase L5ubiquitin thioesterase L5
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000284563, ENST00000366843, 
ENST00000366844, ENST00000391874, 
Fusion gene scores* DoF score12 X 11 X 8=10564 X 3 X 4=48
# samples 164
** MAII scorelog2(16/1056*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ENAH [Title/Abstract] AND UCHL5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointENAH(225840388)-UCHL5(193020947), # samples:2
Anticipated loss of major functional domain due to fusion event.ENAH-UCHL5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ENAH-UCHL5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ENAH-UCHL5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ENAH-UCHL5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ENAH-UCHL5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ENAH-UCHL5 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ENAH-UCHL5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUCHL5

GO:0016579

protein deubiquitination

18922472


check buttonFusion gene breakpoints across ENAH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across UCHL5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-CU-A5W6-01AENAHchr1

225840388

-UCHL5chr1

193020947

-


Top

Fusion Gene ORF analysis for ENAH-UCHL5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000284563ENST00000367452ENAHchr1

225840388

-UCHL5chr1

193020947

-
5CDS-5UTRENST00000284563ENST00000483156ENAHchr1

225840388

-UCHL5chr1

193020947

-
5CDS-5UTRENST00000284563ENST00000530098ENAHchr1

225840388

-UCHL5chr1

193020947

-
5CDS-5UTRENST00000366843ENST00000367452ENAHchr1

225840388

-UCHL5chr1

193020947

-
5CDS-5UTRENST00000366843ENST00000483156ENAHchr1

225840388

-UCHL5chr1

193020947

-
5CDS-5UTRENST00000366843ENST00000530098ENAHchr1

225840388

-UCHL5chr1

193020947

-
5CDS-5UTRENST00000366844ENST00000367452ENAHchr1

225840388

-UCHL5chr1

193020947

-
5CDS-5UTRENST00000366844ENST00000483156ENAHchr1

225840388

-UCHL5chr1

193020947

-
5CDS-5UTRENST00000366844ENST00000530098ENAHchr1

225840388

-UCHL5chr1

193020947

-
Frame-shiftENST00000284563ENST00000367449ENAHchr1

225840388

-UCHL5chr1

193020947

-
Frame-shiftENST00000284563ENST00000367451ENAHchr1

225840388

-UCHL5chr1

193020947

-
Frame-shiftENST00000284563ENST00000367454ENAHchr1

225840388

-UCHL5chr1

193020947

-
Frame-shiftENST00000284563ENST00000367455ENAHchr1

225840388

-UCHL5chr1

193020947

-
Frame-shiftENST00000366843ENST00000367449ENAHchr1

225840388

-UCHL5chr1

193020947

-
Frame-shiftENST00000366843ENST00000367451ENAHchr1

225840388

-UCHL5chr1

193020947

-
Frame-shiftENST00000366843ENST00000367454ENAHchr1

225840388

-UCHL5chr1

193020947

-
Frame-shiftENST00000366843ENST00000367455ENAHchr1

225840388

-UCHL5chr1

193020947

-
Frame-shiftENST00000366844ENST00000367449ENAHchr1

225840388

-UCHL5chr1

193020947

-
Frame-shiftENST00000366844ENST00000367451ENAHchr1

225840388

-UCHL5chr1

193020947

-
Frame-shiftENST00000366844ENST00000367454ENAHchr1

225840388

-UCHL5chr1

193020947

-
Frame-shiftENST00000366844ENST00000367455ENAHchr1

225840388

-UCHL5chr1

193020947

-
In-frameENST00000284563ENST00000367448ENAHchr1

225840388

-UCHL5chr1

193020947

-
In-frameENST00000366843ENST00000367448ENAHchr1

225840388

-UCHL5chr1

193020947

-
In-frameENST00000366844ENST00000367448ENAHchr1

225840388

-UCHL5chr1

193020947

-
intron-3CDSENST00000391874ENST00000367448ENAHchr1

225840388

-UCHL5chr1

193020947

-
intron-3CDSENST00000391874ENST00000367449ENAHchr1

225840388

-UCHL5chr1

193020947

-
intron-3CDSENST00000391874ENST00000367451ENAHchr1

225840388

-UCHL5chr1

193020947

-
intron-3CDSENST00000391874ENST00000367454ENAHchr1

225840388

-UCHL5chr1

193020947

-
intron-3CDSENST00000391874ENST00000367455ENAHchr1

225840388

-UCHL5chr1

193020947

-
intron-5UTRENST00000391874ENST00000367452ENAHchr1

225840388

-UCHL5chr1

193020947

-
intron-5UTRENST00000391874ENST00000483156ENAHchr1

225840388

-UCHL5chr1

193020947

-
intron-5UTRENST00000391874ENST00000530098ENAHchr1

225840388

-UCHL5chr1

193020947

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366844ENAHchr1225840388-ENST00000367448UCHL5chr1193020947-18144576721361229
ENST00000366843ENAHchr1225840388-ENST00000367448UCHL5chr1193020947-17173605751264229
ENST00000284563ENAHchr1225840388-ENST00000367448UCHL5chr1193020947-138831246935229

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366844ENST00000367448ENAHchr1225840388-UCHL5chr1193020947-0.0012328830.99876714
ENST00000366843ENST00000367448ENAHchr1225840388-UCHL5chr1193020947-0.0008883320.9991117
ENST00000284563ENST00000367448ENAHchr1225840388-UCHL5chr1193020947-0.0009948740.99900514

Top

Fusion Genomic Features for ENAH-UCHL5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for ENAH-UCHL5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:225840388/chr1:193020947)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114135_2651571.0Coiled coilOntology_term=ECO:0000255
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114557_5871571.0Coiled coilOntology_term=ECO:0000255
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115135_2651592.0Coiled coilOntology_term=ECO:0000255
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115557_5871592.0Coiled coilOntology_term=ECO:0000255
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114310_3731571.0Compositional biasNote=Pro-rich
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115310_3731592.0Compositional biasNote=Pro-rich
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-1141_1111571.0DomainWH1
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-1151_1111592.0DomainWH1
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114400_4031571.0MotifNote=KLKR
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115400_4031592.0MotifNote=KLKR
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114156_2001571.0RegionNote=9 X 5 AA tandem repeats of [LMQ]-E-[QR]-E-[QR]
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114391_4111571.0RegionNote=EVH2 block A
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114391_5881571.0RegionNote=EVH2
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114442_4591571.0RegionNote=EVH2 block B
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114554_5881571.0RegionNote=EVH2 block C
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115156_2001592.0RegionNote=9 X 5 AA tandem repeats of [LMQ]-E-[QR]-E-[QR]
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115391_4111592.0RegionNote=EVH2 block A
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115391_5881592.0RegionNote=EVH2
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115442_4591592.0RegionNote=EVH2 block B
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115554_5881592.0RegionNote=EVH2 block C
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114156_1601571.0RepeatNote=1
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114161_1651571.0RepeatNote=2
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114166_1701571.0RepeatNote=3
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114171_1751571.0RepeatNote=4
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114176_1801571.0RepeatNote=5
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114181_1851571.0RepeatNote=6
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114186_1901571.0RepeatNote=7
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114191_1951571.0RepeatNote=8
HgeneENAHchr1:225840388chr1:193020947ENST00000366843-114196_2001571.0RepeatNote=9
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115156_1601592.0RepeatNote=1
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115161_1651592.0RepeatNote=2
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115166_1701592.0RepeatNote=3
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115171_1751592.0RepeatNote=4
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115176_1801592.0RepeatNote=5
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115181_1851592.0RepeatNote=6
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115186_1901592.0RepeatNote=7
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115191_1951592.0RepeatNote=8
HgeneENAHchr1:225840388chr1:193020947ENST00000366844-115196_2001592.0RepeatNote=9


Top

Fusion Gene Sequence for ENAH-UCHL5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>26540_26540_1_ENAH-UCHL5_ENAH_chr1_225840388_ENST00000284563_UCHL5_chr1_193020947_ENST00000367448_length(transcript)=1388nt_BP=31nt
GGGGAAGCCTCTGCGCCGCCGGCACCATGAGGTTGCCGAGGAGCCCAAGTAGAAGAAATATGGAGTTTAGAGCCTGAGAATTTTGAAAAA
TTAAAGCCAGTTCATGGGTTAATTTTTCTTTTCAAGTGGCAGCCAGGAGAAGAACCAGCAGGCTCTGTGGTTCAGGACTCCCGACTTGAC
ACGATATTTTTTGCTAAGCAGGTAATTAATAATGCTTGTGCTACTCAAGCCATAGTGAGTGTGTTACTGAACTGTACCCACCAGGATGTC
CATTTAGGCGAGACATTATCAGAGTTTAAAGAATTTTCACAAAGTTTTGATGCAGCTATGAAAGGCTTGGCACTGAGCAATTCAGATGTG
ATTCGACAAGTACACAACAGTTTCGCCAGACAGCAAATGTTTGAATTTGATACGAAGACATCAGCAAAAGAAGAAGATGCTTTTCACTTT
GTCAGTTATGTTCCTGTTAATGGGAGACTGTATGAATTAGATGGATTAAGAGAAGGACCGATTGATTTAGGTGCATGCAATCAAGATGAT
TGGATCAGTGCAGTAAGGCCTGTCATAGAAAAAAGGATACAAAAGTACAGTGAAGGTGAAATTCGATTTAATTTAATGGCCATTGTGTCT
GACAGAAAAATGATATATGAGCAGAAGATAGCAGAGTTACAAAGACAACTTGCAGAGGAACCCATGGATACAGATCAAGGTAATAGTATG
TTAAGTGCTATTCAGTCAGAAGTTGCCAAAAATCAGATGCTTATTGAAGAAGAAGTACAGAAATTAAAAAGATACAAGATTGAGAATATC
AGAAGGAAGCATAATTATCTGCCTTTCATTATGGAATTGTTAAAGACTTTAGCAGAACACCAGCAGTTAATACCACTAGTAGAAAAGTTT
GAGAAACACTTTGAGAAGACACTACTAGGCAAATAAAATTTTGGACCATTAACTTAAAGACGAGAATACATGGGAAAATAGGATAAAAGA
ACAAGGTGTGAGAAGGAATAGAAGGAAACAAACAGGAAAGATATGGCTGCACCATGCAGTGCTACTATATGCTGAGATTCTACAGGATGA
GATTTTTGAATAGCTGAGGCAGTTGCCTATAATCTGTGATGACATAAAAGTATTTGACCTAAAATCTTTTTATTTGCAAAATAATAAATA
AAAAGTGATTCTCCCTCGGCATGGCTATAATGAACTTGGTTAGAACCTATAAATGTTTTTGTTATGTGAGACTTTTTAACCGATGAATTC
GTTGAATACACACCACATTTAAAAACTGCCTAGGAGGTAATCCAAAAATATATAGTTATAAAACTTCTTGTATTATGTACCAAATCTCTT
TCTTAAAATATAAAATAAAATTATCTAGTTTAAGATTA

>26540_26540_1_ENAH-UCHL5_ENAH_chr1_225840388_ENST00000284563_UCHL5_chr1_193020947_ENST00000367448_length(amino acids)=229AA_BP=
MNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAKEEDAFHFVSYVPVNGRLYELDGLREGPID
LGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEPMDTDQGNSMLSAIQSEVAKNQMLIEEEVQKL
KRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKFEKHFEKTLLGK

--------------------------------------------------------------
>26540_26540_2_ENAH-UCHL5_ENAH_chr1_225840388_ENST00000366843_UCHL5_chr1_193020947_ENST00000367448_length(transcript)=1717nt_BP=360nt
CGGCGGCCGGGCGCGCGGCCCCGGCGGGCACCCCTCAGAGGGCGGCCGAGGAAGCTCCGGGAGGAGGAGCAGGACCACGAGGAGGTGGGA
GGCGGCGGCCGCCTGGGGACCAGCTCCGCGCCTCGGCCTCTCCGCCCCCTCCCCAGCCTTTCTCTCGCCCTCTTCTCCCACACTCCCGGC
CGGCGCCTCGGCTTTGTGCGAGGAGATGGTGTAGCCCCCTGGCCGCCGAAGGAGGAGCCGGACACTTGTCTCCCGTCTCCGAGCTGCTCC
CCACCCCTGGAGGAGAGACCCCCCCCTCGGCTCGGCGCCTTCTGCGTCTCCCGGCTGGTGGGGAAGCCTCTGCGCCGCCGGCACCATGAG
GTTGCCGAGGAGCCCAAGTAGAAGAAATATGGAGTTTAGAGCCTGAGAATTTTGAAAAATTAAAGCCAGTTCATGGGTTAATTTTTCTTT
TCAAGTGGCAGCCAGGAGAAGAACCAGCAGGCTCTGTGGTTCAGGACTCCCGACTTGACACGATATTTTTTGCTAAGCAGGTAATTAATA
ATGCTTGTGCTACTCAAGCCATAGTGAGTGTGTTACTGAACTGTACCCACCAGGATGTCCATTTAGGCGAGACATTATCAGAGTTTAAAG
AATTTTCACAAAGTTTTGATGCAGCTATGAAAGGCTTGGCACTGAGCAATTCAGATGTGATTCGACAAGTACACAACAGTTTCGCCAGAC
AGCAAATGTTTGAATTTGATACGAAGACATCAGCAAAAGAAGAAGATGCTTTTCACTTTGTCAGTTATGTTCCTGTTAATGGGAGACTGT
ATGAATTAGATGGATTAAGAGAAGGACCGATTGATTTAGGTGCATGCAATCAAGATGATTGGATCAGTGCAGTAAGGCCTGTCATAGAAA
AAAGGATACAAAAGTACAGTGAAGGTGAAATTCGATTTAATTTAATGGCCATTGTGTCTGACAGAAAAATGATATATGAGCAGAAGATAG
CAGAGTTACAAAGACAACTTGCAGAGGAACCCATGGATACAGATCAAGGTAATAGTATGTTAAGTGCTATTCAGTCAGAAGTTGCCAAAA
ATCAGATGCTTATTGAAGAAGAAGTACAGAAATTAAAAAGATACAAGATTGAGAATATCAGAAGGAAGCATAATTATCTGCCTTTCATTA
TGGAATTGTTAAAGACTTTAGCAGAACACCAGCAGTTAATACCACTAGTAGAAAAGTTTGAGAAACACTTTGAGAAGACACTACTAGGCA
AATAAAATTTTGGACCATTAACTTAAAGACGAGAATACATGGGAAAATAGGATAAAAGAACAAGGTGTGAGAAGGAATAGAAGGAAACAA
ACAGGAAAGATATGGCTGCACCATGCAGTGCTACTATATGCTGAGATTCTACAGGATGAGATTTTTGAATAGCTGAGGCAGTTGCCTATA
ATCTGTGATGACATAAAAGTATTTGACCTAAAATCTTTTTATTTGCAAAATAATAAATAAAAAGTGATTCTCCCTCGGCATGGCTATAAT
GAACTTGGTTAGAACCTATAAATGTTTTTGTTATGTGAGACTTTTTAACCGATGAATTCGTTGAATACACACCACATTTAAAAACTGCCT
AGGAGGTAATCCAAAAATATATAGTTATAAAACTTCTTGTATTATGTACCAAATCTCTTTCTTAAAATATAAAATAAAATTATCTAGTTT
AAGATTA

>26540_26540_2_ENAH-UCHL5_ENAH_chr1_225840388_ENST00000366843_UCHL5_chr1_193020947_ENST00000367448_length(amino acids)=229AA_BP=
MNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAKEEDAFHFVSYVPVNGRLYELDGLREGPID
LGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEPMDTDQGNSMLSAIQSEVAKNQMLIEEEVQKL
KRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKFEKHFEKTLLGK

--------------------------------------------------------------
>26540_26540_3_ENAH-UCHL5_ENAH_chr1_225840388_ENST00000366844_UCHL5_chr1_193020947_ENST00000367448_length(transcript)=1814nt_BP=457nt
GGTTCCTCGCGGCGATCCCGACTCTCCTCCCGCGGCTGCAGCAGCTGCCGGTTGCACACGGCCTCGGCGGCGGCGCGGCGAGCGCGGGCC
TGTGGAGCGGCGGCCGGGCGCGCGGCCCCGGCGGGCACCCCTCAGAGGGCGGCCGAGGAAGCTCCGGGAGGAGGAGCAGGACCACGAGGA
GGTGGGAGGCGGCGGCCGCCTGGGGACCAGCTCCGCGCCTCGGCCTCTCCGCCCCCTCCCCAGCCTTTCTCTCGCCCTCTTCTCCCACAC
TCCCGGCCGGCGCCTCGGCTTTGTGCGAGGAGATGGTGTAGCCCCCTGGCCGCCGAAGGAGGAGCCGGACACTTGTCTCCCGTCTCCGAG
CTGCTCCCCACCCCTGGAGGAGAGACCCCCCCCTCGGCTCGGCGCCTTCTGCGTCTCCCGGCTGGTGGGGAAGCCTCTGCGCCGCCGGCA
CCATGAGGTTGCCGAGGAGCCCAAGTAGAAGAAATATGGAGTTTAGAGCCTGAGAATTTTGAAAAATTAAAGCCAGTTCATGGGTTAATT
TTTCTTTTCAAGTGGCAGCCAGGAGAAGAACCAGCAGGCTCTGTGGTTCAGGACTCCCGACTTGACACGATATTTTTTGCTAAGCAGGTA
ATTAATAATGCTTGTGCTACTCAAGCCATAGTGAGTGTGTTACTGAACTGTACCCACCAGGATGTCCATTTAGGCGAGACATTATCAGAG
TTTAAAGAATTTTCACAAAGTTTTGATGCAGCTATGAAAGGCTTGGCACTGAGCAATTCAGATGTGATTCGACAAGTACACAACAGTTTC
GCCAGACAGCAAATGTTTGAATTTGATACGAAGACATCAGCAAAAGAAGAAGATGCTTTTCACTTTGTCAGTTATGTTCCTGTTAATGGG
AGACTGTATGAATTAGATGGATTAAGAGAAGGACCGATTGATTTAGGTGCATGCAATCAAGATGATTGGATCAGTGCAGTAAGGCCTGTC
ATAGAAAAAAGGATACAAAAGTACAGTGAAGGTGAAATTCGATTTAATTTAATGGCCATTGTGTCTGACAGAAAAATGATATATGAGCAG
AAGATAGCAGAGTTACAAAGACAACTTGCAGAGGAACCCATGGATACAGATCAAGGTAATAGTATGTTAAGTGCTATTCAGTCAGAAGTT
GCCAAAAATCAGATGCTTATTGAAGAAGAAGTACAGAAATTAAAAAGATACAAGATTGAGAATATCAGAAGGAAGCATAATTATCTGCCT
TTCATTATGGAATTGTTAAAGACTTTAGCAGAACACCAGCAGTTAATACCACTAGTAGAAAAGTTTGAGAAACACTTTGAGAAGACACTA
CTAGGCAAATAAAATTTTGGACCATTAACTTAAAGACGAGAATACATGGGAAAATAGGATAAAAGAACAAGGTGTGAGAAGGAATAGAAG
GAAACAAACAGGAAAGATATGGCTGCACCATGCAGTGCTACTATATGCTGAGATTCTACAGGATGAGATTTTTGAATAGCTGAGGCAGTT
GCCTATAATCTGTGATGACATAAAAGTATTTGACCTAAAATCTTTTTATTTGCAAAATAATAAATAAAAAGTGATTCTCCCTCGGCATGG
CTATAATGAACTTGGTTAGAACCTATAAATGTTTTTGTTATGTGAGACTTTTTAACCGATGAATTCGTTGAATACACACCACATTTAAAA
ACTGCCTAGGAGGTAATCCAAAAATATATAGTTATAAAACTTCTTGTATTATGTACCAAATCTCTTTCTTAAAATATAAAATAAAATTAT
CTAGTTTAAGATTA

>26540_26540_3_ENAH-UCHL5_ENAH_chr1_225840388_ENST00000366844_UCHL5_chr1_193020947_ENST00000367448_length(amino acids)=229AA_BP=
MNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAKEEDAFHFVSYVPVNGRLYELDGLREGPID
LGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEPMDTDQGNSMLSAIQSEVAKNQMLIEEEVQKL
KRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKFEKHFEKTLLGK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ENAH-UCHL5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneUCHL5chr1:225840388chr1:193020947ENST00000367448012313_32925.333333333333332410.3333333333333ADRM1
TgeneUCHL5chr1:225840388chr1:193020947ENST00000367449011313_32925.333333333333332317.0ADRM1
TgeneUCHL5chr1:225840388chr1:193020947ENST00000367454011313_32925.333333333333332329.0ADRM1
TgeneUCHL5chr1:225840388chr1:193020947ENST00000367455011313_32925.333333333333332330.0ADRM1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ENAH-UCHL5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ENAH-UCHL5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneENAHC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneENAHC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneENAHC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human