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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCAR1-CAAP1 (FusionGDB2 ID:HG55749TG79886)

Fusion Gene Summary for CCAR1-CAAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CCAR1-CAAP1
Fusion gene ID: hg55749tg79886
HgeneTgene
Gene symbol

CCAR1

CAAP1

Gene ID

55749

79886

Gene namecell division cycle and apoptosis regulator 1caspase activity and apoptosis inhibitor 1
Synonyms-C9orf82|CAAP
Cytomap('CCAR1')('CAAP1')

10q21.3

9p21.2

Type of geneprotein-codingprotein-coding
Descriptioncell division cycle and apoptosis regulator protein 1cell cycle and apoptosis regulatory protein 1death inducer with SAP domaincaspase activity and apoptosis inhibitor 1conserved anti-apoptotic protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265872, ENST00000535016, 
ENST00000543719, ENST00000483264, 
Fusion gene scores* DoF score13 X 11 X 8=11443 X 2 X 3=18
# samples 174
** MAII scorelog2(17/1144*10)=-2.75048040064069
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CCAR1 [Title/Abstract] AND CAAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCAR1(70514584)-CAAP1(26887511), # samples:1
Anticipated loss of major functional domain due to fusion event.CCAR1-CAAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCAR1-CAAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCAR1-CAAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CCAR1-CAAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCCAR1

GO:0043065

positive regulation of apoptotic process

12816952


check buttonFusion gene breakpoints across CCAR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CAAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N8-A4PLCCAR1chr10

70514584

+CAAP1chr9

26887511

-


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Fusion Gene ORF analysis for CCAR1-CAAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000265872ENST00000495958CCAR1chr10

70514584

+CAAP1chr9

26887511

-
5CDS-5UTRENST00000265872ENST00000535437CCAR1chr10

70514584

+CAAP1chr9

26887511

-
5CDS-5UTRENST00000535016ENST00000495958CCAR1chr10

70514584

+CAAP1chr9

26887511

-
5CDS-5UTRENST00000535016ENST00000535437CCAR1chr10

70514584

+CAAP1chr9

26887511

-
5CDS-5UTRENST00000543719ENST00000495958CCAR1chr10

70514584

+CAAP1chr9

26887511

-
5CDS-5UTRENST00000543719ENST00000535437CCAR1chr10

70514584

+CAAP1chr9

26887511

-
5CDS-intronENST00000265872ENST00000520187CCAR1chr10

70514584

+CAAP1chr9

26887511

-
5CDS-intronENST00000535016ENST00000520187CCAR1chr10

70514584

+CAAP1chr9

26887511

-
5CDS-intronENST00000543719ENST00000520187CCAR1chr10

70514584

+CAAP1chr9

26887511

-
In-frameENST00000265872ENST00000333916CCAR1chr10

70514584

+CAAP1chr9

26887511

-
In-frameENST00000535016ENST00000333916CCAR1chr10

70514584

+CAAP1chr9

26887511

-
In-frameENST00000543719ENST00000333916CCAR1chr10

70514584

+CAAP1chr9

26887511

-
intron-3CDSENST00000483264ENST00000333916CCAR1chr10

70514584

+CAAP1chr9

26887511

-
intron-5UTRENST00000483264ENST00000495958CCAR1chr10

70514584

+CAAP1chr9

26887511

-
intron-5UTRENST00000483264ENST00000535437CCAR1chr10

70514584

+CAAP1chr9

26887511

-
intron-intronENST00000483264ENST00000520187CCAR1chr10

70514584

+CAAP1chr9

26887511

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000535016CCAR1chr1070514584+ENST00000333916CAAP1chr926887511-393115321192314731
ENST00000265872CCAR1chr1070514584+ENST00000333916CAAP1chr926887511-397615771192359746
ENST00000543719CCAR1chr1070514584+ENST00000333916CAAP1chr926887511-392515261132308731

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535016ENST00000333916CCAR1chr1070514584+CAAP1chr926887511-0.0008489140.9991511
ENST00000265872ENST00000333916CCAR1chr1070514584+CAAP1chr926887511-0.0010501070.99894994
ENST00000543719ENST00000333916CCAR1chr1070514584+CAAP1chr926887511-0.0008301840.9991698

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Fusion Genomic Features for CCAR1-CAAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CCAR1-CAAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:70514584/chr9:26887511)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCAR1chr10:70514584chr9:26887511ENST00000265872+1225293_3614861151.0Compositional biasNote=Arg-rich
HgeneCCAR1chr10:70514584chr9:26887511ENST00000265872+122573_794861151.0Compositional biasNote=Poly-Ala
HgeneCCAR1chr10:70514584chr9:26887511ENST00000535016+1124293_3614711136.0Compositional biasNote=Arg-rich
HgeneCCAR1chr10:70514584chr9:26887511ENST00000535016+112473_794711136.0Compositional biasNote=Poly-Ala
HgeneCCAR1chr10:70514584chr9:26887511ENST00000543719+1124293_3614711136.0Compositional biasNote=Arg-rich
HgeneCCAR1chr10:70514584chr9:26887511ENST00000543719+112473_794711136.0Compositional biasNote=Poly-Ala
TgeneCAAP1chr10:70514584chr9:26887511ENST0000033391606281_311101362.0Coiled coilOntology_term=ECO:0000255
TgeneCAAP1chr10:70514584chr9:26887511ENST0000053543706281_3110217.0Coiled coilOntology_term=ECO:0000255
TgeneCAAP1chr10:70514584chr9:26887511ENST000005354370619_250217.0Compositional biasNote=Poly-Ala

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCAR1chr10:70514584chr9:26887511ENST00000265872+12251033_11144861151.0Coiled coilOntology_term=ECO:0000255
HgeneCCAR1chr10:70514584chr9:26887511ENST00000265872+1225594_6184861151.0Coiled coilOntology_term=ECO:0000255
HgeneCCAR1chr10:70514584chr9:26887511ENST00000535016+11241033_11144711136.0Coiled coilOntology_term=ECO:0000255
HgeneCCAR1chr10:70514584chr9:26887511ENST00000535016+1124594_6184711136.0Coiled coilOntology_term=ECO:0000255
HgeneCCAR1chr10:70514584chr9:26887511ENST00000543719+11241033_11144711136.0Coiled coilOntology_term=ECO:0000255
HgeneCCAR1chr10:70514584chr9:26887511ENST00000543719+1124594_6184711136.0Coiled coilOntology_term=ECO:0000255
HgeneCCAR1chr10:70514584chr9:26887511ENST00000265872+1225673_8894861151.0Compositional biasNote=Glu-rich
HgeneCCAR1chr10:70514584chr9:26887511ENST00000535016+1124673_8894711136.0Compositional biasNote=Glu-rich
HgeneCCAR1chr10:70514584chr9:26887511ENST00000543719+1124673_8894711136.0Compositional biasNote=Glu-rich
HgeneCCAR1chr10:70514584chr9:26887511ENST00000265872+1225636_6704861151.0DomainSAP
HgeneCCAR1chr10:70514584chr9:26887511ENST00000535016+1124636_6704711136.0DomainSAP
HgeneCCAR1chr10:70514584chr9:26887511ENST00000543719+1124636_6704711136.0DomainSAP
TgeneCAAP1chr10:70514584chr9:26887511ENST000003339160619_25101362.0Compositional biasNote=Poly-Ala


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Fusion Gene Sequence for CCAR1-CAAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13515_13515_1_CCAR1-CAAP1_CCAR1_chr10_70514584_ENST00000265872_CAAP1_chr9_26887511_ENST00000333916_length(transcript)=3976nt_BP=1577nt
GAAGTTGGCGCATGCGCCTAAAGCTGACGGGTTTGAAATGGCTTCGATGTTAGCCGGGACCCGACTCAGATCGATGCTATAGAAGACAAA
CAAGGGAAGGTTTTTTTTCCTTTTGCATCATGGCTCAATTTGGAGGACAGAAGAATCCGCCATGGGCTACTCAGTTTACAGCCACTGCAG
TATCACAGCCAGCTGCACTGGGTGTTCAACAGCCATCACTCCTTGGAGCATCTCCTACCATTTATACACAGCAAACTGCATTGGCAGCAG
CAGGCCTTACCACACAAACTCCAGCAAACTATCAGTTAACACAAACTGCTGCATTGCAGCAACAAGCCGCAGCTGCAGCAGCTGCATTAC
AACAGCAATATTCACAACCTCAGCAGGCCCTGTATAGTGTGCAACAACAGTTACAGCAACCCCAGCAAACCCTCTTAACACAGCCAGCTG
TTGCACTGCCTACAAGCCTTAGCCTGTCTACTCCTCAGCCAACAGCACAAATAACTGTATCATATCCAACACCAAGGTCCAGTCAACAGC
AAACCCAGCCTCAGAAGCAGCGTGTTTTCACAGGGGTGGTTACAAAACTACATGATACGTTTGGATTTGTGGATGAAGATGTATTCTTTC
AGCTTAGTGCTGTCAAAGGGAAAACCCCCCAAGTAGGTGACAGAGTATTGGTTGAAGCTACTTATAATCCTAATATGCCTTTTAAATGGA
ATGCACAGAGAATTCAAACACTACCAAATCAGAATCAGTCGCAAACCCAGCCATTACTGAAGACTCCTCCTGCTGTACTTCAGCCAATTG
CACCACAGACAACATTTGGTGTTCAGACTCAGCCCCAGCCCCAGTCACTGCTGCAGGCACAGATTTCAGCAGCTTCTATTACACCACTAT
TGCAGACTCAACCACAGCCCTTATTACAGCAGCCTCAGCAAAAAGCTGGTTTATTGCAGCCTCCTGTTCGTATAGTTTCACAGCCACAAC
CGGCACGACGATTAGATCCCCCATCCCGATTTTCAGGAAGAAATGACAGAGGGGATCAAGTGCCTAACAGAAAAGATGATCGAAGTCGTG
AGAGAGAGAGAGAAAGACGTAGATCGAGAGAAAGATCACCTCAGAGGAAACGTTCCCGGGAAAGATCTCCACGAAGAGAGCGAGAGCGAT
CACCTCGGAGAGTTCGACGTGTTGTTCCACGTTACACAGTTCAGTTTTCAAAGTTTTCTTTAGATTGTCCCAGTTGTGACATGATGGAAC
TAAGGCGCCGTTATCAAAATTTGTATATACCTAGTGACTTTTTTGATGCTCAATTTACATGGGTGGATGCTTTCCCTTTGTCAAGACCAT
TTCAGCTGGGAAATTACTGCAATTTTTATGTAATGCACAGAGAAGTAGAGTCCTTAGAAAAAAATATGGCCATTCTTGATCCACCAGATG
CTGACCACTTATACAGTGCAAAGGTAATGCTGATGGCTAGCCCTAGTATGGAAGATTTATATCATAAGTCATGTGCTCTTGCTGAGGACC
CACAAGAACTTCGAGATGGATTCCAACATCCTGCTAGACTTGTTAAGGAAACTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCT
TGGCAGAGCACAGTGACCTTGAAGAAGGTGGACTGGACCTGACTGTGTCATTGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAA
TGCTTCAGCAGTGCTTCTGTATTATAGGAGAGAAAAAGTTACAGAAGATGCTTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTA
AAAAACTATGCCAGGAACAGTTAGAGCTCCTGTCTGAAAAAAAAATTTTGAAGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGG
AAGAGGAAGCAGATGATGGTTCTAAGATGGGATCTGATTTAGTCAGTCAGCAAGACATCTGTATAGATTCTGCTTCATCCGTGAGAGAGA
ATAAGCAACCTGAAGGTTTGGAATTAAAACAAGGAAAAGGGGAAGATAGTGATGTACTCAGTATAAATGCAGATGCTTATGACAGCGACA
TAGAAGGCCCATGCAACGAAGAAGCAGCTGCTCCCGAGGCACCAGAAAATACAGTCCAAAGTGAAGCTGGTCAGATAGATGACCTGGAGA
AAGACATTGAGAAAAGTGTGAATGAGATTCTAGGACTGGCAGAGTCTAGCCCAAACGAACCCAAAGCAGCCACCCTGGCTGTTCCTCCAC
CAGAAGATGTTCAACCTTCTGCACAGCAACTGGAGCTGCTAGAACTTGAGATGAGGGCAAGAGCGATTAAAGCCCTAATGAAAGCTGGTG
ATATAAAAAAGCCAGCCTAGGTATTTAACTTGATTTTGAATTTTAGGTATGTTTGAACAAAGCCACATCATTTAATTTTGTATCTAAAAT
TTATTTGGGGTCTTATATGTTATTTCTCATGTAACCCTTATTAGGACTCATTTTAGCCCTAAATTACCTGTGGCTGTTTCTTTTTATTTT
TTTGACTACTTTTATATTATAAATGTGTGTTACTGTCTTATGAATTCATGGCAATATAGTTGGATAGCCTGGATACTTTGTTAGATGAGT
ATTTAGCTGTGTCTGCAAATCTTAAAAGCCATTAGCAAAGAGTCGTGGTATTTTTTTCTTTATTTTTAAATGTTTGGGCACCAAACCTAA
AAGCAAAAGATTGACGAAGCATGTTTCTCTTAAGGCTACTTGTATTTTACAATACAATATTAAATTATTTAATTTGAGAAATTTAGTTTT
GCTTATATGCACTTTTTAAATATATACTATTTTGAAGATTCCTTATGTAAATGCAAATTTCCTAGTTAAAACCGAATAACAGAGATCTGA
AATGACTGAGAAAAACTTTTTTATTAAAGGAAGGAATTAATTTAAGGCAATTTTTAACTATGTAGAACTAATTGCCCATGTTTAATTATA
GCAGACACGCCATTCTAACAGGTATTTGATACCATTGGATGCATTATTCTAGGTTTTTTCTTTAATAAAAATGGAACAAGTTTTCATTTA
CATTCCAAGCTGTCAGGAAATGAAGAATATTTTATTATCTAGGATTTTATCTGATGTAGTTGCTTAAAGATCTGATGTGCTATAATTCCA
TGAATCAGAAATAATAAAATGCTATCATTCTGGATCTGAAGACTTTTGATACTTTTTCAAAAGCAAAATTAATTTCAGGAACCTTTGATA
AGTTGTTGTTATAATTAATCTAATTTTGTATAGTTTTTGTAAATAAATTACCATCCTTCCACAATTAGGGATGCTTTTATCCCCCCATCA
CTAATTGCAGTTGTTTGATACCAAAATAAATTTACGTAGAGATCCTTAACTTAAAATAAATTAATTTTTTCAAAAAACATAAATCTGGAA
CTGTTGTTTCTATATTTGATAACAAATACAGTATATTTTATTTATAAGCCATGGTCTACTGATACTGTATGAGGACTTTCCTTATATATA
AAAGTTGCAGGGATTGTGTTTTATTAGCTGCTTTAATTATGTTAATTTTAGAGAGTTTTTAAATGGAAATAGAGGACATTTATGAAACGC
TGGAATTGCAGTTACAAATTCTTTTTGTTGTTGTTGTTCCTGAACATGCCTTGGAATAATTCTACCATTTTTTCCCCCTCCATAAATCTT
TCTAATAAAGCATAGAAAAAGCCTATATGATTTTAAATGCTTCTCTTAAGCTGGTAAACAGATTTGAGTTATGAGTTCATTGTTATTGCT
TCAAGATGAAAAGACAGTGATATAATTTTTCTATTTCAACTTAAAAGTAATAGTTAATATGCTAAAGTAGTACAGAATAAACTTTATTGC
TGCTTACTAACTACAAAATACTGTAGATGGCATCTGTATGATTAAACATATAAAGTAAAACAGGTCTGAGGGCTTTGTAGATGATTAAAG

>13515_13515_1_CCAR1-CAAP1_CCAR1_chr10_70514584_ENST00000265872_CAAP1_chr9_26887511_ENST00000333916_length(amino acids)=746AA_BP=486
MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQQYSQPQQA
LYSVQQQLQQPQQTLLTQPAVALPTSLSLSTPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLSAVKGKTP
QVGDRVLVEATYNPNMPFKWNAQRIQTLPNQNQSQTQPLLKTPPAVLQPIAPQTTFGVQTQPQPQSLLQAQISAASITPLLQTQPQPLLQ
QPQQKAGLLQPPVRIVSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVP
RYTVQFSKFSLDCPSCDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAILDPPDADHLYSAKVM
LMASPSMEDLYHKSCALAEDPQELRDGFQHPARLVKETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIG
EKKLQKMLPDVLKNCSIEEIKKLCQEQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELK
QGKGEDSDVLSINADAYDSDIEGPCNEEAAAPEAPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPNEPKAATLAVPPPEDVQPSAQQ

--------------------------------------------------------------
>13515_13515_2_CCAR1-CAAP1_CCAR1_chr10_70514584_ENST00000535016_CAAP1_chr9_26887511_ENST00000333916_length(transcript)=3931nt_BP=1532nt
GAAGTTGGCGCATGCGCCTAAAGCTGACGGGTTTGAAATGGCTTCGATGTTAGCCGGGACCCGACTCAGATCGATGCTATAGAAGACAAA
CAAGGGAAGGTTTTTTTTCCTTTTGCATCATGGCTCAATTTGGAGGACAGAAGAATCCGCCATGGGCTACTCAGTTTACAGCCACTGCAG
TATCACAGCCAGCTGCACTGGGTGTTCAACAGCCATCACTCCTTGGAGCATCTCCTACCATTTATACACAGCAAACTGCATTGGCAGCAG
CAGGCCTTACCACACAAACTCCAGCAAACTATCAGTTAACACAAACTGCTGCATTGCAGCAACAAGCCGCAGCTGCAGCAGCTGCATTAC
AACAGTTACAGCAACCCCAGCAAACCCTCTTAACACAGCCAGCTGTTGCACTGCCTACAAGCCTTAGCCTGTCTACTCCTCAGCCAACAG
CACAAATAACTGTATCATATCCAACACCAAGGTCCAGTCAACAGCAAACCCAGCCTCAGAAGCAGCGTGTTTTCACAGGGGTGGTTACAA
AACTACATGATACGTTTGGATTTGTGGATGAAGATGTATTCTTTCAGCTTAGTGCTGTCAAAGGGAAAACCCCCCAAGTAGGTGACAGAG
TATTGGTTGAAGCTACTTATAATCCTAATATGCCTTTTAAATGGAATGCACAGAGAATTCAAACACTACCAAATCAGAATCAGTCGCAAA
CCCAGCCATTACTGAAGACTCCTCCTGCTGTACTTCAGCCAATTGCACCACAGACAACATTTGGTGTTCAGACTCAGCCCCAGCCCCAGT
CACTGCTGCAGGCACAGATTTCAGCAGCTTCTATTACACCACTATTGCAGACTCAACCACAGCCCTTATTACAGCAGCCTCAGCAAAAAG
CTGGTTTATTGCAGCCTCCTGTTCGTATAGTTTCACAGCCACAACCGGCACGACGATTAGATCCCCCATCCCGATTTTCAGGAAGAAATG
ACAGAGGGGATCAAGTGCCTAACAGAAAAGATGATCGAAGTCGTGAGAGAGAGAGAGAAAGACGTAGATCGAGAGAAAGATCACCTCAGA
GGAAACGTTCCCGGGAAAGATCTCCACGAAGAGAGCGAGAGCGATCACCTCGGAGAGTTCGACGTGTTGTTCCACGTTACACAGTTCAGT
TTTCAAAGTTTTCTTTAGATTGTCCCAGTTGTGACATGATGGAACTAAGGCGCCGTTATCAAAATTTGTATATACCTAGTGACTTTTTTG
ATGCTCAATTTACATGGGTGGATGCTTTCCCTTTGTCAAGACCATTTCAGCTGGGAAATTACTGCAATTTTTATGTAATGCACAGAGAAG
TAGAGTCCTTAGAAAAAAATATGGCCATTCTTGATCCACCAGATGCTGACCACTTATACAGTGCAAAGGTAATGCTGATGGCTAGCCCTA
GTATGGAAGATTTATATCATAAGTCATGTGCTCTTGCTGAGGACCCACAAGAACTTCGAGATGGATTCCAACATCCTGCTAGACTTGTTA
AGGAAACTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCTTGGCAGAGCACAGTGACCTTGAAGAAGGTGGACTGGACCTGACTG
TGTCATTGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAATGCTTCAGCAGTGCTTCTGTATTATAGGAGAGAAAAAGTTACAGA
AGATGCTTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTAAAAAACTATGCCAGGAACAGTTAGAGCTCCTGTCTGAAAAAAAAA
TTTTGAAGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGGAAGAGGAAGCAGATGATGGTTCTAAGATGGGATCTGATTTAGTCA
GTCAGCAAGACATCTGTATAGATTCTGCTTCATCCGTGAGAGAGAATAAGCAACCTGAAGGTTTGGAATTAAAACAAGGAAAAGGGGAAG
ATAGTGATGTACTCAGTATAAATGCAGATGCTTATGACAGCGACATAGAAGGCCCATGCAACGAAGAAGCAGCTGCTCCCGAGGCACCAG
AAAATACAGTCCAAAGTGAAGCTGGTCAGATAGATGACCTGGAGAAAGACATTGAGAAAAGTGTGAATGAGATTCTAGGACTGGCAGAGT
CTAGCCCAAACGAACCCAAAGCAGCCACCCTGGCTGTTCCTCCACCAGAAGATGTTCAACCTTCTGCACAGCAACTGGAGCTGCTAGAAC
TTGAGATGAGGGCAAGAGCGATTAAAGCCCTAATGAAAGCTGGTGATATAAAAAAGCCAGCCTAGGTATTTAACTTGATTTTGAATTTTA
GGTATGTTTGAACAAAGCCACATCATTTAATTTTGTATCTAAAATTTATTTGGGGTCTTATATGTTATTTCTCATGTAACCCTTATTAGG
ACTCATTTTAGCCCTAAATTACCTGTGGCTGTTTCTTTTTATTTTTTTGACTACTTTTATATTATAAATGTGTGTTACTGTCTTATGAAT
TCATGGCAATATAGTTGGATAGCCTGGATACTTTGTTAGATGAGTATTTAGCTGTGTCTGCAAATCTTAAAAGCCATTAGCAAAGAGTCG
TGGTATTTTTTTCTTTATTTTTAAATGTTTGGGCACCAAACCTAAAAGCAAAAGATTGACGAAGCATGTTTCTCTTAAGGCTACTTGTAT
TTTACAATACAATATTAAATTATTTAATTTGAGAAATTTAGTTTTGCTTATATGCACTTTTTAAATATATACTATTTTGAAGATTCCTTA
TGTAAATGCAAATTTCCTAGTTAAAACCGAATAACAGAGATCTGAAATGACTGAGAAAAACTTTTTTATTAAAGGAAGGAATTAATTTAA
GGCAATTTTTAACTATGTAGAACTAATTGCCCATGTTTAATTATAGCAGACACGCCATTCTAACAGGTATTTGATACCATTGGATGCATT
ATTCTAGGTTTTTTCTTTAATAAAAATGGAACAAGTTTTCATTTACATTCCAAGCTGTCAGGAAATGAAGAATATTTTATTATCTAGGAT
TTTATCTGATGTAGTTGCTTAAAGATCTGATGTGCTATAATTCCATGAATCAGAAATAATAAAATGCTATCATTCTGGATCTGAAGACTT
TTGATACTTTTTCAAAAGCAAAATTAATTTCAGGAACCTTTGATAAGTTGTTGTTATAATTAATCTAATTTTGTATAGTTTTTGTAAATA
AATTACCATCCTTCCACAATTAGGGATGCTTTTATCCCCCCATCACTAATTGCAGTTGTTTGATACCAAAATAAATTTACGTAGAGATCC
TTAACTTAAAATAAATTAATTTTTTCAAAAAACATAAATCTGGAACTGTTGTTTCTATATTTGATAACAAATACAGTATATTTTATTTAT
AAGCCATGGTCTACTGATACTGTATGAGGACTTTCCTTATATATAAAAGTTGCAGGGATTGTGTTTTATTAGCTGCTTTAATTATGTTAA
TTTTAGAGAGTTTTTAAATGGAAATAGAGGACATTTATGAAACGCTGGAATTGCAGTTACAAATTCTTTTTGTTGTTGTTGTTCCTGAAC
ATGCCTTGGAATAATTCTACCATTTTTTCCCCCTCCATAAATCTTTCTAATAAAGCATAGAAAAAGCCTATATGATTTTAAATGCTTCTC
TTAAGCTGGTAAACAGATTTGAGTTATGAGTTCATTGTTATTGCTTCAAGATGAAAAGACAGTGATATAATTTTTCTATTTCAACTTAAA
AGTAATAGTTAATATGCTAAAGTAGTACAGAATAAACTTTATTGCTGCTTACTAACTACAAAATACTGTAGATGGCATCTGTATGATTAA

>13515_13515_2_CCAR1-CAAP1_CCAR1_chr10_70514584_ENST00000535016_CAAP1_chr9_26887511_ENST00000333916_length(amino acids)=731AA_BP=471
MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQLQQPQQTL
LTQPAVALPTSLSLSTPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLSAVKGKTPQVGDRVLVEATYNPN
MPFKWNAQRIQTLPNQNQSQTQPLLKTPPAVLQPIAPQTTFGVQTQPQPQSLLQAQISAASITPLLQTQPQPLLQQPQQKAGLLQPPVRI
VSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVPRYTVQFSKFSLDCPS
CDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAILDPPDADHLYSAKVMLMASPSMEDLYHKSC
ALAEDPQELRDGFQHPARLVKETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNC
SIEEIKKLCQEQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELKQGKGEDSDVLSINAD
AYDSDIEGPCNEEAAAPEAPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPNEPKAATLAVPPPEDVQPSAQQLELLELEMRARAIKA

--------------------------------------------------------------
>13515_13515_3_CCAR1-CAAP1_CCAR1_chr10_70514584_ENST00000543719_CAAP1_chr9_26887511_ENST00000333916_length(transcript)=3925nt_BP=1526nt
TGCGCCTAAAGCTGACGGGTTTGAAATGGCTTCGATGTTAGCCGGGACCCGACTCAGGTGAAGATCGATGCTATAGAAGACAAACAAGGG
AAGGTTTTTTTTCCTTTTGCATCATGGCTCAATTTGGAGGACAGAAGAATCCGCCATGGGCTACTCAGTTTACAGCCACTGCAGTATCAC
AGCCAGCTGCACTGGGTGTTCAACAGCCATCACTCCTTGGAGCATCTCCTACCATTTATACACAGCAAACTGCATTGGCAGCAGCAGGCC
TTACCACACAAACTCCAGCAAACTATCAGTTAACACAAACTGCTGCATTGCAGCAACAAGCCGCAGCTGCAGCAGCTGCATTACAACAGT
TACAGCAACCCCAGCAAACCCTCTTAACACAGCCAGCTGTTGCACTGCCTACAAGCCTTAGCCTGTCTACTCCTCAGCCAACAGCACAAA
TAACTGTATCATATCCAACACCAAGGTCCAGTCAACAGCAAACCCAGCCTCAGAAGCAGCGTGTTTTCACAGGGGTGGTTACAAAACTAC
ATGATACGTTTGGATTTGTGGATGAAGATGTATTCTTTCAGCTTAGTGCTGTCAAAGGGAAAACCCCCCAAGTAGGTGACAGAGTATTGG
TTGAAGCTACTTATAATCCTAATATGCCTTTTAAATGGAATGCACAGAGAATTCAAACACTACCAAATCAGAATCAGTCGCAAACCCAGC
CATTACTGAAGACTCCTCCTGCTGTACTTCAGCCAATTGCACCACAGACAACATTTGGTGTTCAGACTCAGCCCCAGCCCCAGTCACTGC
TGCAGGCACAGATTTCAGCAGCTTCTATTACACCACTATTGCAGACTCAACCACAGCCCTTATTACAGCAGCCTCAGCAAAAAGCTGGTT
TATTGCAGCCTCCTGTTCGTATAGTTTCACAGCCACAACCGGCACGACGATTAGATCCCCCATCCCGATTTTCAGGAAGAAATGACAGAG
GGGATCAAGTGCCTAACAGAAAAGATGATCGAAGTCGTGAGAGAGAGAGAGAAAGACGTAGATCGAGAGAAAGATCACCTCAGAGGAAAC
GTTCCCGGGAAAGATCTCCACGAAGAGAGCGAGAGCGATCACCTCGGAGAGTTCGACGTGTTGTTCCACGTTACACAGTTCAGTTTTCAA
AGTTTTCTTTAGATTGTCCCAGTTGTGACATGATGGAACTAAGGCGCCGTTATCAAAATTTGTATATACCTAGTGACTTTTTTGATGCTC
AATTTACATGGGTGGATGCTTTCCCTTTGTCAAGACCATTTCAGCTGGGAAATTACTGCAATTTTTATGTAATGCACAGAGAAGTAGAGT
CCTTAGAAAAAAATATGGCCATTCTTGATCCACCAGATGCTGACCACTTATACAGTGCAAAGGTAATGCTGATGGCTAGCCCTAGTATGG
AAGATTTATATCATAAGTCATGTGCTCTTGCTGAGGACCCACAAGAACTTCGAGATGGATTCCAACATCCTGCTAGACTTGTTAAGGAAA
CTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCTTGGCAGAGCACAGTGACCTTGAAGAAGGTGGACTGGACCTGACTGTGTCAT
TGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAATGCTTCAGCAGTGCTTCTGTATTATAGGAGAGAAAAAGTTACAGAAGATGC
TTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTAAAAAACTATGCCAGGAACAGTTAGAGCTCCTGTCTGAAAAAAAAATTTTGA
AGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGGAAGAGGAAGCAGATGATGGTTCTAAGATGGGATCTGATTTAGTCAGTCAGC
AAGACATCTGTATAGATTCTGCTTCATCCGTGAGAGAGAATAAGCAACCTGAAGGTTTGGAATTAAAACAAGGAAAAGGGGAAGATAGTG
ATGTACTCAGTATAAATGCAGATGCTTATGACAGCGACATAGAAGGCCCATGCAACGAAGAAGCAGCTGCTCCCGAGGCACCAGAAAATA
CAGTCCAAAGTGAAGCTGGTCAGATAGATGACCTGGAGAAAGACATTGAGAAAAGTGTGAATGAGATTCTAGGACTGGCAGAGTCTAGCC
CAAACGAACCCAAAGCAGCCACCCTGGCTGTTCCTCCACCAGAAGATGTTCAACCTTCTGCACAGCAACTGGAGCTGCTAGAACTTGAGA
TGAGGGCAAGAGCGATTAAAGCCCTAATGAAAGCTGGTGATATAAAAAAGCCAGCCTAGGTATTTAACTTGATTTTGAATTTTAGGTATG
TTTGAACAAAGCCACATCATTTAATTTTGTATCTAAAATTTATTTGGGGTCTTATATGTTATTTCTCATGTAACCCTTATTAGGACTCAT
TTTAGCCCTAAATTACCTGTGGCTGTTTCTTTTTATTTTTTTGACTACTTTTATATTATAAATGTGTGTTACTGTCTTATGAATTCATGG
CAATATAGTTGGATAGCCTGGATACTTTGTTAGATGAGTATTTAGCTGTGTCTGCAAATCTTAAAAGCCATTAGCAAAGAGTCGTGGTAT
TTTTTTCTTTATTTTTAAATGTTTGGGCACCAAACCTAAAAGCAAAAGATTGACGAAGCATGTTTCTCTTAAGGCTACTTGTATTTTACA
ATACAATATTAAATTATTTAATTTGAGAAATTTAGTTTTGCTTATATGCACTTTTTAAATATATACTATTTTGAAGATTCCTTATGTAAA
TGCAAATTTCCTAGTTAAAACCGAATAACAGAGATCTGAAATGACTGAGAAAAACTTTTTTATTAAAGGAAGGAATTAATTTAAGGCAAT
TTTTAACTATGTAGAACTAATTGCCCATGTTTAATTATAGCAGACACGCCATTCTAACAGGTATTTGATACCATTGGATGCATTATTCTA
GGTTTTTTCTTTAATAAAAATGGAACAAGTTTTCATTTACATTCCAAGCTGTCAGGAAATGAAGAATATTTTATTATCTAGGATTTTATC
TGATGTAGTTGCTTAAAGATCTGATGTGCTATAATTCCATGAATCAGAAATAATAAAATGCTATCATTCTGGATCTGAAGACTTTTGATA
CTTTTTCAAAAGCAAAATTAATTTCAGGAACCTTTGATAAGTTGTTGTTATAATTAATCTAATTTTGTATAGTTTTTGTAAATAAATTAC
CATCCTTCCACAATTAGGGATGCTTTTATCCCCCCATCACTAATTGCAGTTGTTTGATACCAAAATAAATTTACGTAGAGATCCTTAACT
TAAAATAAATTAATTTTTTCAAAAAACATAAATCTGGAACTGTTGTTTCTATATTTGATAACAAATACAGTATATTTTATTTATAAGCCA
TGGTCTACTGATACTGTATGAGGACTTTCCTTATATATAAAAGTTGCAGGGATTGTGTTTTATTAGCTGCTTTAATTATGTTAATTTTAG
AGAGTTTTTAAATGGAAATAGAGGACATTTATGAAACGCTGGAATTGCAGTTACAAATTCTTTTTGTTGTTGTTGTTCCTGAACATGCCT
TGGAATAATTCTACCATTTTTTCCCCCTCCATAAATCTTTCTAATAAAGCATAGAAAAAGCCTATATGATTTTAAATGCTTCTCTTAAGC
TGGTAAACAGATTTGAGTTATGAGTTCATTGTTATTGCTTCAAGATGAAAAGACAGTGATATAATTTTTCTATTTCAACTTAAAAGTAAT
AGTTAATATGCTAAAGTAGTACAGAATAAACTTTATTGCTGCTTACTAACTACAAAATACTGTAGATGGCATCTGTATGATTAAACATAT

>13515_13515_3_CCAR1-CAAP1_CCAR1_chr10_70514584_ENST00000543719_CAAP1_chr9_26887511_ENST00000333916_length(amino acids)=731AA_BP=471
MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQLQQPQQTL
LTQPAVALPTSLSLSTPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLSAVKGKTPQVGDRVLVEATYNPN
MPFKWNAQRIQTLPNQNQSQTQPLLKTPPAVLQPIAPQTTFGVQTQPQPQSLLQAQISAASITPLLQTQPQPLLQQPQQKAGLLQPPVRI
VSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVPRYTVQFSKFSLDCPS
CDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAILDPPDADHLYSAKVMLMASPSMEDLYHKSC
ALAEDPQELRDGFQHPARLVKETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNC
SIEEIKKLCQEQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELKQGKGEDSDVLSINAD
AYDSDIEGPCNEEAAAPEAPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPNEPKAATLAVPPPEDVQPSAQQLELLELEMRARAIKA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CCAR1-CAAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneCCAR1chr10:70514584chr9:26887511ENST00000265872+12251_249486.01151.0AR
HgeneCCAR1chr10:70514584chr9:26887511ENST00000535016+11241_249471.01136.0AR
HgeneCCAR1chr10:70514584chr9:26887511ENST00000543719+11241_249471.01136.0AR


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCCAR1chr10:70514584chr9:26887511ENST00000265872+1225643_1150486.01151.0GATA1
HgeneCCAR1chr10:70514584chr9:26887511ENST00000535016+1124643_1150471.01136.0GATA1
HgeneCCAR1chr10:70514584chr9:26887511ENST00000543719+1124643_1150471.01136.0GATA1
HgeneCCAR1chr10:70514584chr9:26887511ENST00000265872+1225203_660486.01151.0GATA2
HgeneCCAR1chr10:70514584chr9:26887511ENST00000535016+1124203_660471.01136.0GATA2
HgeneCCAR1chr10:70514584chr9:26887511ENST00000543719+1124203_660471.01136.0GATA2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCAR1-CAAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCAR1-CAAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource