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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DEPDC1B-PDE4D (FusionGDB2 ID:HG55789TG5144)

Fusion Gene Summary for DEPDC1B-PDE4D

check button Fusion gene summary
Fusion gene informationFusion gene name: DEPDC1B-PDE4D
Fusion gene ID: hg55789tg5144
HgeneTgene
Gene symbol

DEPDC1B

PDE4D

Gene ID

55789

5144

Gene nameDEP domain containing 1Bphosphodiesterase 4D
SynonymsBRCC3|XTP1ACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1
Cytomap('DEPDC1B')('PDE4D')

5q12.1

5q11.2-q12.1

Type of geneprotein-codingprotein-coding
DescriptionDEP domain-containing protein 1BHBV X-transactivated gene 8 proteinHBV XAg-transactivated protein 8HBxAg transactivated protein 1breast cancer cell 3cAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265036, ENST00000453022, 
ENST00000545085, ENST00000509006, 
ENST00000545085, ENST00000509006, 
ENST00000265036, ENST00000453022, 
Fusion gene scores* DoF score8 X 9 X 7=50420 X 19 X 7=2660
# samples 1425
** MAII scorelog2(14/504*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/2660*10)=-3.41142624572647
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DEPDC1B [Title/Abstract] AND PDE4D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDEPDC1B(59938638)-PDE4D(59481514), # samples:1
DEPDC1B(59938639)-PDE4D(59481514), # samples:1
DEPDC1B(59982789)-PDE4D(59481514), # samples:1
DEPDC1B(59982789)-PDE4D(59284544), # samples:1
Anticipated loss of major functional domain due to fusion event.PDE4D-DEPDC1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PDE4D-DEPDC1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PDE4D-DEPDC1B seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PDE4D-DEPDC1B seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PDE4D-DEPDC1B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-CU-A3KJ-01ADEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
ChimerDB4BLCATCGA-CU-A3KJDEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
ChimerDB4BRCATCGA-AC-A2BK-01ADEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
ChimerDB4LIHCTCGA-CC-A5UC-01ADEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-


Top

Fusion Gene ORF analysis for DEPDC1B-PDE4D

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000265036ENST00000502484DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-5UTRENST00000265036ENST00000502484DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-5UTRENST00000265036ENST00000502484DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-5UTRENST00000453022ENST00000502484DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-5UTRENST00000453022ENST00000502484DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-5UTRENST00000453022ENST00000502484DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-5UTRENST00000545085ENST00000502484DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-5UTRENST00000545085ENST00000502484DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-5UTRENST00000545085ENST00000502484DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000317118DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000317118DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000317118DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000317118DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000265036ENST00000340635DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000340635DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000340635DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000340635DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000265036ENST00000358923DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000358923DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000358923DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000358923DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000265036ENST00000360047DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000360047DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000360047DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000360047DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000265036ENST00000405755DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000405755DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000405755DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000405755DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000265036ENST00000502484DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000265036ENST00000502575DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000502575DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000502575DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000502575DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000265036ENST00000503258DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000503258DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000503258DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000503258DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000265036ENST00000503947DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000503947DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000503947DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000503947DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000265036ENST00000507116DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000507116DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000507116DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000507116DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000265036ENST00000546160DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000546160DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000546160DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000265036ENST00000546160DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000453022ENST00000317118DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000317118DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000317118DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000317118DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000453022ENST00000340635DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000340635DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000340635DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000340635DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000453022ENST00000358923DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000358923DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000358923DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000358923DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000453022ENST00000360047DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000360047DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000360047DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000360047DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000453022ENST00000405755DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000405755DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000405755DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000405755DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000453022ENST00000502484DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000453022ENST00000502575DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000502575DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000502575DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000502575DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000453022ENST00000503258DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000503258DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000503258DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000503258DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000453022ENST00000503947DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000503947DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000503947DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000503947DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000453022ENST00000507116DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000507116DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000507116DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000507116DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000453022ENST00000546160DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000546160DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000546160DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000453022ENST00000546160DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000545085ENST00000317118DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000317118DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000317118DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000317118DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000545085ENST00000340635DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000340635DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000340635DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000340635DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000545085ENST00000358923DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000358923DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000358923DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000358923DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000545085ENST00000360047DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000360047DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000360047DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000360047DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000545085ENST00000405755DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000405755DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000405755DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000405755DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000545085ENST00000502484DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000545085ENST00000502575DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000502575DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000502575DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000502575DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000545085ENST00000503258DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000503258DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000503258DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000503258DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000545085ENST00000503947DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000503947DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000503947DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000503947DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000545085ENST00000507116DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000507116DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000507116DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000507116DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
5CDS-intronENST00000545085ENST00000546160DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000546160DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000546160DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
5CDS-intronENST00000545085ENST00000546160DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
intron-5UTRENST00000509006ENST00000502484DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
intron-5UTRENST00000509006ENST00000502484DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
intron-5UTRENST00000509006ENST00000502484DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000317118DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000317118DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000317118DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000317118DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
intron-intronENST00000509006ENST00000340635DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000340635DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000340635DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000340635DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
intron-intronENST00000509006ENST00000358923DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000358923DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000358923DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000358923DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
intron-intronENST00000509006ENST00000360047DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000360047DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000360047DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000360047DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
intron-intronENST00000509006ENST00000405755DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000405755DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000405755DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000405755DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
intron-intronENST00000509006ENST00000502484DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
intron-intronENST00000509006ENST00000502575DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000502575DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000502575DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000502575DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
intron-intronENST00000509006ENST00000503258DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000503258DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000503258DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000503258DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
intron-intronENST00000509006ENST00000503947DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000503947DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000503947DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000503947DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
intron-intronENST00000509006ENST00000507116DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000507116DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000507116DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000507116DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-
intron-intronENST00000509006ENST00000546160DEPDC1Bchr5

59938639

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000546160DEPDC1Bchr5

59938638

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000546160DEPDC1Bchr5

59982789

-PDE4Dchr5

59481514

-
intron-intronENST00000509006ENST00000546160DEPDC1Bchr5

59982789

-PDE4Dchr5

59284544

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DEPDC1B-PDE4D


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for DEPDC1B-PDE4D


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:59938638/:59481514)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DEPDC1B-PDE4D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DEPDC1B-PDE4D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DEPDC1B-PDE4D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DEPDC1B-PDE4D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDEPDC1BC2239176Liver carcinoma1CTD_human
TgeneC3553250ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE4CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0011581Depressive disorder3PSYGENET
TgeneC0004096Asthma2CTD_human
TgeneC0011570Mental Depression2PSYGENET
TgeneC0033578Prostatic Neoplasms2CTD_human
TgeneC0220659Acrodysostosis2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0376358Malignant neoplasm of prostate2CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0236733Amphetamine-Related Disorders1CTD_human
TgeneC0236804Amphetamine Addiction1CTD_human
TgeneC0236807Amphetamine Abuse1CTD_human
TgeneC3276228ACRODYSOSTOSIS 1 WITH OR WITHOUT HORMONE RESISTANCE1CTD_human;GENOMICS_ENGLAND