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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACPP-NPY (FusionGDB2 ID:HG55TG4852)

Fusion Gene Summary for ACPP-NPY

check button Fusion gene summary
Fusion gene informationFusion gene name: ACPP-NPY
Fusion gene ID: hg55tg4852
HgeneTgene
Gene symbol

ACPP

NPY

Gene ID

55

4852

Gene nameacid phosphatase 3neuropeptide Y
Synonyms5'-NT|ACP-3|ACPP|TM-PAPPYY4
Cytomap('ACPP')('NPY')

3q22.1

7p15.3

Type of geneprotein-codingprotein-coding
Descriptionprostatic acid phosphataseTMPaseacid phosphatase, prostateecto-5'-nucleotidaseprostatic acid phosphotasethiamine monophosphatasepro-neuropeptide Yprepro-neuropeptide Y
Modification date2020031320200313
UniProtAcc.

P01303

Ensembl transtripts involved in fusion geneENST00000336375, ENST00000351273, 
ENST00000475741, ENST00000489084, 
Fusion gene scores* DoF score28 X 17 X 4=19046 X 8 X 4=192
# samples 317
** MAII scorelog2(31/1904*10)=-2.61869335803371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/192*10)=-1.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACPP [Title/Abstract] AND NPY [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACPP(132075699)-NPY(24331282), # samples:1
Anticipated loss of major functional domain due to fusion event.ACPP-NPY seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACPP

GO:0046085

adenosine metabolic process

18940592


check buttonFusion gene breakpoints across ACPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NPY (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-CH-5741-01AACPPchr3

132075699

+NPYchr7

24331282

+


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Fusion Gene ORF analysis for ACPP-NPY

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000336375ENST00000405982ACPPchr3

132075699

+NPYchr7

24331282

+
Frame-shiftENST00000351273ENST00000242152ACPPchr3

132075699

+NPYchr7

24331282

+
Frame-shiftENST00000351273ENST00000407573ACPPchr3

132075699

+NPYchr7

24331282

+
Frame-shiftENST00000475741ENST00000242152ACPPchr3

132075699

+NPYchr7

24331282

+
Frame-shiftENST00000475741ENST00000405982ACPPchr3

132075699

+NPYchr7

24331282

+
Frame-shiftENST00000475741ENST00000407573ACPPchr3

132075699

+NPYchr7

24331282

+
In-frameENST00000336375ENST00000242152ACPPchr3

132075699

+NPYchr7

24331282

+
In-frameENST00000336375ENST00000407573ACPPchr3

132075699

+NPYchr7

24331282

+
In-frameENST00000351273ENST00000405982ACPPchr3

132075699

+NPYchr7

24331282

+
intron-3CDSENST00000489084ENST00000242152ACPPchr3

132075699

+NPYchr7

24331282

+
intron-3CDSENST00000489084ENST00000405982ACPPchr3

132075699

+NPYchr7

24331282

+
intron-3CDSENST00000489084ENST00000407573ACPPchr3

132075699

+NPYchr7

24331282

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336375ACPPchr3132075699+ENST00000242152NPYchr724331282+31582955661064332
ENST00000336375ACPPchr3132075699+ENST00000407573NPYchr724331282+31012955661064332
ENST00000351273ACPPchr3132075699+ENST00000405982NPYchr724331282+13501188261222398

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336375ENST00000242152ACPPchr3132075699+NPYchr724331282+0.0001234540.9998765
ENST00000336375ENST00000407573ACPPchr3132075699+NPYchr724331282+0.0001307820.9998692
ENST00000351273ENST00000405982ACPPchr3132075699+NPYchr724331282+0.0009706030.9990294

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Fusion Genomic Features for ACPP-NPY


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACPPchr3132075699+NPYchr724331281+0.0076194360.99238056
ACPPchr3132075699+NPYchr724331281+0.0076194360.99238056

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACPP-NPY


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:132075699/chr7:24331282)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NPY

P01303

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ACPP-NPY


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1456_1456_1_ACPP-NPY_ACPP_chr3_132075699_ENST00000336375_NPY_chr7_24331282_ENST00000242152_length(transcript)=3158nt_BP=2955nt
TCAATCCCTTAATTAAATAGCTTCCCCTCTACAGGCTTTTGAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAAC
ATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCCTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTA
CTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGCATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAA
TCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGGGCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGA
AAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATATTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTG
GCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATCCTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAA
GATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTTTTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGG
CTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAACTTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTAC
GACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTACCCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAA
TTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAGAGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCAC
ATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCATCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTA
GATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCCACTTGACGGAATTGTACTTTGAGAAGGGGTACTGAAGACAGTACAGATTA
GTGTGCACAGAGATCTCTGTAGAAGGAGTAGCTGCCCTTTCTCAGGGCAGATGATGCTTTGAGAACATACTTTGGCCATTACCCCCAGCT
TTGAGGAAAATGGGCTTTGGATGATTATTTTATGTTTTAGGGACCCCCAACCTCAGGCAATTCCTACCTCTTCACCTGACCCTGCCCCCA
CTTGCCATAAAACTTAGCTAAGTTTTGTTTTGTTTTTCAGCGTTAATGTAAAGGGGCAGCAGTGCCAAAATATAATCAGAGATAAAGCTT
AGGTCAAAGTTCATAGAGTTCCCATGAACTATATGACTGGCCACACAGGATCTTTTGTATTTAAGGATTCTGAGATTTTGCTTGAGCAGG
ATTAGATAAGGCTGTTCTTTAAATGTCTGAAATGGAACAGATTTCAAAAAAAAACCCCACAATCTAGGATGGGAACAAGGAAGGAAAGAT
GTGAATAGGCTGATGGGCAAAAAACCAATTTACCCATCAGTTCCAGCCTTCTCTCAAGGAGAGGCAAAGAAAGGAGATACAGTGGAGACA
TCTGGAAAGTTTTCTCCACTGGAAAACTGCTACTATCTGTTTTTATATTTCTGTTAAAATATATGAGGCTACAGAACTAAAAATTAAAAC
CTCTTTGTGTCCCTTGGTCCTGGAACATTTATGTTCCTTTTAAAGAAACAAAAATCAAACTTTACAGAAAGATTTGATGTATGTAATACA
TATAGCAGCTCTTGAAGTATATATATCATAGCAAATAAGTCATCTGATGAGAACAAGCTATTTGGGCACAACACATCAGGAAAGAGAGCA
CCACGTGATGGAGTTTCTCTAGAAGCTCCAGTGATAAGAGATGTTGACTCTAAAGTTGATTTAAGGCCAGGCATGGTGGTTTACGCCTAT
AATCCCAGCATTTTGGGAGTCCGAGGTGGGCAGATCACTTGAGCTCAGGAGGTCAAGATCAGCCTGGGCAACATGGTGAAACCTGGTCTC
TACATAAAATACAAAAACTTAGATGGGCATGGTGGTGTGTGCCTATAGTCCCACTACTTGTGGGGCTAAGGCAGGAGGATCACTTGAGCC
CCGGAGGTCGAGGCTACAGTGAGCCAAGAGTGCACTACTGTACTCCAGCCAGGGCAAGAGAGCGAGACCCTGTCTCAATAAATAAATAAA
TAAATAAATAAATAAATAAATAAATAAATAAAAACAAAGTTGATTAAGAAAGGAAGTATAGGCCAGGCACAGTGGCTCACACCTGTAATC
CTTGCATTTTGGAAGGCTGAGGCAGGAGGATCACTTTAGGCCTGGTGTGTTCAAGACCAGCCTGGTCAACATAGTGAGACACTGTCTCTA
CCAAAAAAAGGAAGGAAGGGACACATATCAAACTGAAACAAAATTAGAAATGTAATTATGTTCTAAGTGCCTCCAAGTTCAAAACTTATT
GGAATGTTGAGAGTGTGGTTACGAAATACGTTAGGAGGACAAAAGGAATGTGTAAGTCTTTAATGCCGATATCTTCAGAAAACCTAAGCA
AACTTACAGGTCCTGCTGAAACTGCCCACTCTGCAAGAAGAAATCATGATATAGCTTTGCCATGTGGCAGATCTACATGTCTAGAGAACA
CTGTGCTCTATTACCATTATGGATAAAGATGAGATGGTTTCTAGAGATGGTTTCTACTGGCTGCCAGAATCTAGAGCAAAGCCATCCCCG
CTCCTGGTTGGTCACAGAATGACTGACAAAGACATCGATTGATATGCTTCTTTGTGTTATTTCCCTCCCAAGTAAATGTTTGTCCTTGGG
TCCATTTTCTATGCTTGTAACTGTCTTCTAGCAGTGAGCCAAATGTAAAATAGTGAATAAAGTCATTATTAGGAAGCTTGAAGACCCTGC
AATGTGGTGATGGGAAATGAGACTTGCTCTCTGGCCTTTTCCTATTTTCAGCCCATATTTCATCGTGTAAAACGAGAATCCACCCATCCT
ACCAATGCATGCAGCCACTGTGCTGAATTCTGCAATGTTTTCCTTTGTCATCATTGTATATATGTGTGTTTAAATAAAGTATCATGCATT
CAAAAGTG

>1456_1456_1_ACPP-NPY_ACPP_chr3_132075699_ENST00000336375_NPY_chr7_24331282_ENST00000242152_length(amino acids)=332AA_BP=
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGY

--------------------------------------------------------------
>1456_1456_2_ACPP-NPY_ACPP_chr3_132075699_ENST00000336375_NPY_chr7_24331282_ENST00000407573_length(transcript)=3101nt_BP=2955nt
TCAATCCCTTAATTAAATAGCTTCCCCTCTACAGGCTTTTGAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAAC
ATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCCTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTA
CTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGCATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAA
TCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGGGCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGA
AAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATATTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTG
GCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATCCTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAA
GATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTTTTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGG
CTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAACTTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTAC
GACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTACCCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAA
TTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAGAGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCAC
ATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCATCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTA
GATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCCACTTGACGGAATTGTACTTTGAGAAGGGGTACTGAAGACAGTACAGATTA
GTGTGCACAGAGATCTCTGTAGAAGGAGTAGCTGCCCTTTCTCAGGGCAGATGATGCTTTGAGAACATACTTTGGCCATTACCCCCAGCT
TTGAGGAAAATGGGCTTTGGATGATTATTTTATGTTTTAGGGACCCCCAACCTCAGGCAATTCCTACCTCTTCACCTGACCCTGCCCCCA
CTTGCCATAAAACTTAGCTAAGTTTTGTTTTGTTTTTCAGCGTTAATGTAAAGGGGCAGCAGTGCCAAAATATAATCAGAGATAAAGCTT
AGGTCAAAGTTCATAGAGTTCCCATGAACTATATGACTGGCCACACAGGATCTTTTGTATTTAAGGATTCTGAGATTTTGCTTGAGCAGG
ATTAGATAAGGCTGTTCTTTAAATGTCTGAAATGGAACAGATTTCAAAAAAAAACCCCACAATCTAGGATGGGAACAAGGAAGGAAAGAT
GTGAATAGGCTGATGGGCAAAAAACCAATTTACCCATCAGTTCCAGCCTTCTCTCAAGGAGAGGCAAAGAAAGGAGATACAGTGGAGACA
TCTGGAAAGTTTTCTCCACTGGAAAACTGCTACTATCTGTTTTTATATTTCTGTTAAAATATATGAGGCTACAGAACTAAAAATTAAAAC
CTCTTTGTGTCCCTTGGTCCTGGAACATTTATGTTCCTTTTAAAGAAACAAAAATCAAACTTTACAGAAAGATTTGATGTATGTAATACA
TATAGCAGCTCTTGAAGTATATATATCATAGCAAATAAGTCATCTGATGAGAACAAGCTATTTGGGCACAACACATCAGGAAAGAGAGCA
CCACGTGATGGAGTTTCTCTAGAAGCTCCAGTGATAAGAGATGTTGACTCTAAAGTTGATTTAAGGCCAGGCATGGTGGTTTACGCCTAT
AATCCCAGCATTTTGGGAGTCCGAGGTGGGCAGATCACTTGAGCTCAGGAGGTCAAGATCAGCCTGGGCAACATGGTGAAACCTGGTCTC
TACATAAAATACAAAAACTTAGATGGGCATGGTGGTGTGTGCCTATAGTCCCACTACTTGTGGGGCTAAGGCAGGAGGATCACTTGAGCC
CCGGAGGTCGAGGCTACAGTGAGCCAAGAGTGCACTACTGTACTCCAGCCAGGGCAAGAGAGCGAGACCCTGTCTCAATAAATAAATAAA
TAAATAAATAAATAAATAAATAAATAAATAAAAACAAAGTTGATTAAGAAAGGAAGTATAGGCCAGGCACAGTGGCTCACACCTGTAATC
CTTGCATTTTGGAAGGCTGAGGCAGGAGGATCACTTTAGGCCTGGTGTGTTCAAGACCAGCCTGGTCAACATAGTGAGACACTGTCTCTA
CCAAAAAAAGGAAGGAAGGGACACATATCAAACTGAAACAAAATTAGAAATGTAATTATGTTCTAAGTGCCTCCAAGTTCAAAACTTATT
GGAATGTTGAGAGTGTGGTTACGAAATACGTTAGGAGGACAAAAGGAATGTGTAAGTCTTTAATGCCGATATCTTCAGAAAACCTAAGCA
AACTTACAGGTCCTGCTGAAACTGCCCACTCTGCAAGAAGAAATCATGATATAGCTTTGCCATGTGGCAGATCTACATGTCTAGAGAACA
CTGTGCTCTATTACCATTATGGATAAAGATGAGATGGTTTCTAGAGATGGTTTCTACTGGCTGCCAGAATCTAGAGCAAAGCCATCCCCG
CTCCTGGTTGGTCACAGAATGACTGACAAAGACATCGATTGATATGCTTCTTTGTGTTATTTCCCTCCCAAGTAAATGTTTGTCCTTGGG
TCCATTTTCTATGCTTGTAACTGTCTTCTAGCAGTGAGCCAAATGTAAAATAGTGAATAAAGTCATTATTAGGAAGCTTGAAGACCCTGC
AATGTGGTGATGGGAAATGAGACTTGCTCTCTGGCCTTTTCCTATTTTCAGCCCATATTTCATCGTGTAAAACGAGAATCCACCCATCCT
ACCAATGCATGCAGCCACTGTGCTGAATTCTGCAATGTTTT

>1456_1456_2_ACPP-NPY_ACPP_chr3_132075699_ENST00000336375_NPY_chr7_24331282_ENST00000407573_length(amino acids)=332AA_BP=
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGY

--------------------------------------------------------------
>1456_1456_3_ACPP-NPY_ACPP_chr3_132075699_ENST00000351273_NPY_chr7_24331282_ENST00000405982_length(transcript)=1350nt_BP=1188nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC
TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC
CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG
AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA
TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC
ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC
TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA
CCACAAACAGCCATCAAGGCTTGAAGACCCTGCAATGTGGTGATGGGAAATGAGACTTGCTCTCTGGCCTTTTCCTATTTTCAGCCCATA
TTTCATCGTGTAAAACGAGAATCCACCCATCCTACCAATGCATGCAGCCACTGTGCTGAATTCTGCAATGTTTTCCTTTGTCATCATTGT


>1456_1456_3_ACPP-NPY_ACPP_chr3_132075699_ENST00000351273_NPY_chr7_24331282_ENST00000405982_length(amino acids)=398AA_BP=
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCP
LERFAELVGPVIPQDWSTECMTTNSHQGLKTLQCGDGK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACPP-NPY


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACPP-NPY


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNPYP01303DB00191PhentermineInhibitorSmall moleculeApproved|Illicit

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Related Diseases for ACPP-NPY


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0011581Depressive disorder7CTD_human;PSYGENET
TgeneC0041696Unipolar Depression7CTD_human;PSYGENET
TgeneC0001973Alcoholic Intoxication, Chronic6CTD_human;PSYGENET
TgeneC0011570Mental Depression5PSYGENET
TgeneC0525045Mood Disorders5PSYGENET
TgeneC1269683Major Depressive Disorder5PSYGENET
TgeneC0003123Anorexia3CTD_human
TgeneC0022333Jacksonian Seizure3CTD_human
TgeneC0036572Seizures3CTD_human
TgeneC0085762Alcohol abuse3CTD_human;PSYGENET
TgeneC0149958Complex partial seizures3CTD_human
TgeneC0234533Generalized seizures3CTD_human
TgeneC0234535Clonic Seizures3CTD_human
TgeneC0270824Visual seizure3CTD_human
TgeneC0270844Tonic Seizures3CTD_human
TgeneC0270846Epileptic drop attack3CTD_human
TgeneC0422850Seizures, Somatosensory3CTD_human
TgeneC0422852Seizures, Auditory3CTD_human
TgeneC0422853Olfactory seizure3CTD_human
TgeneC0422854Gustatory seizure3CTD_human
TgeneC0422855Vertiginous seizure3CTD_human
TgeneC0494475Tonic - clonic seizures3CTD_human
TgeneC0751056Non-epileptic convulsion3CTD_human
TgeneC0751110Single Seizure3CTD_human
TgeneC0751123Atonic Absence Seizures3CTD_human
TgeneC0751494Convulsive Seizures3CTD_human
TgeneC0751495Seizures, Focal3CTD_human
TgeneC0751496Seizures, Sensory3CTD_human
TgeneC3495874Nonepileptic Seizures3CTD_human
TgeneC4048158Convulsions3CTD_human
TgeneC4316903Absence Seizures3CTD_human
TgeneC4317109Epileptic Seizures3CTD_human
TgeneC4317123Myoclonic Seizures3CTD_human
TgeneC4505436Generalized Absence Seizures3CTD_human
TgeneC0011573Endogenous depression2CTD_human
TgeneC0014544Epilepsy2CTD_human
TgeneC0025193Melancholia2CTD_human
TgeneC0036341Schizophrenia2PSYGENET
TgeneC0086133Depressive Syndrome2CTD_human
TgeneC0086237Epilepsy, Cryptogenic2CTD_human
TgeneC0236018Aura2CTD_human
TgeneC0282126Depression, Neurotic2CTD_human
TgeneC0600427Cocaine Dependence2CTD_human;PSYGENET
TgeneC0751111Awakening Epilepsy2CTD_human
TgeneC0001956Alcohol Use Disorder1CTD_human
TgeneC0002395Alzheimer's Disease1CTD_human
TgeneC0003469Anxiety Disorders1CTD_human
TgeneC0004096Asthma1CTD_human
TgeneC0007222Cardiovascular Diseases1CTD_human
TgeneC0007785Cerebral Infarction1CTD_human
TgeneC0008677Bronchitis, Chronic1CTD_human
TgeneC0009171Cocaine Abuse1CTD_human
TgeneC0011265Presenile dementia1CTD_human
TgeneC0013146Drug abuse1CTD_human
TgeneC0013170Drug habituation1CTD_human
TgeneC0013222Drug Use Disorders1CTD_human
TgeneC0014556Epilepsy, Temporal Lobe1CTD_human
TgeneC0014558Uncinate Epilepsy1CTD_human
TgeneC0020564Hypertrophy1CTD_human
TgeneC0025261Memory Disorders1CTD_human
TgeneC0026837Muscle Rigidity1CTD_human
TgeneC0027429Nasal obstruction present finding1CTD_human
TgeneC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneC0035455Rhinitis1CTD_human
TgeneC0036337Schizoaffective Disorder1PSYGENET
TgeneC0038580Substance Dependence1CTD_human
TgeneC0038586Substance Use Disorders1CTD_human
TgeneC0038587Substance Withdrawal Syndrome1CTD_human
TgeneC0085159Seasonal Affective Disorder1PSYGENET
TgeneC0086189Drug Withdrawal Symptoms1CTD_human
TgeneC0087169Withdrawal Symptoms1CTD_human
TgeneC0151564Cogwheel Rigidity1CTD_human
TgeneC0231519Gegenhalten1CTD_human
TgeneC0233608Catatonic Rigidity1CTD_human
TgeneC0233794Memory impairment1CTD_human
TgeneC0236664Alcohol-Related Disorders1PSYGENET
TgeneC0236736Cocaine-Related Disorders1CTD_human
TgeneC0236969Substance-Related Disorders1CTD_human
TgeneC0239325Extensor Rigidity1CTD_human
TgeneC0276496Familial Alzheimer Disease (FAD)1CTD_human
TgeneC0277821Extrapyramidal Rigidity1CTD_human
TgeneC0376280Anxiety States, Neurotic1CTD_human
TgeneC0393672Epilepsy, Benign Psychomotor, Childhood1CTD_human
TgeneC0393682Epilepsy, Lateral Temporal1CTD_human
TgeneC0494463Alzheimer Disease, Late Onset1CTD_human
TgeneC0546126Acute Confusional Senile Dementia1CTD_human
TgeneC0740858Substance abuse problem1CTD_human
TgeneC0750900Alzheimer's Disease, Focal Onset1CTD_human
TgeneC0750901Alzheimer Disease, Early Onset1CTD_human
TgeneC0751010Cerebral Infarction, Left Hemisphere1CTD_human
TgeneC0751011Cerebral Infarction, Right Hemisphere1CTD_human
TgeneC0751012Anterior Choroidal Artery Infarction1CTD_human
TgeneC0751014Subcortical Infarction1CTD_human
TgeneC0751217Hyperkinesia, Generalized1CTD_human
TgeneC0751292Age-Related Memory Disorders1CTD_human
TgeneC0751293Memory Disorder, Semantic1CTD_human
TgeneC0751294Memory Disorder, Spatial1CTD_human
TgeneC0751295Memory Loss1CTD_human
TgeneC0887799Posterior Choroidal Artery Infarction1CTD_human
TgeneC1262477Weight decreased1CTD_human
TgeneC1279420Anxiety neurosis (finding)1CTD_human
TgeneC1320474Nuchal Rigidity1CTD_human
TgeneC1510472Drug Dependence1CTD_human
TgeneC2350170Unilateral Nasal Obstruction1CTD_human
TgeneC2350171Bilateral Nasal Obstruction1CTD_human
TgeneC2362914clinical depression1PSYGENET
TgeneC3887506Hyperkinesia1CTD_human
TgeneC4316881Prescription Drug Abuse1CTD_human
TgeneC4721453Peripheral Nervous System Diseases1CTD_human