Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:C19orf10-CHAF1A (FusionGDB2 ID:HG56005TG10036)

Fusion Gene Summary for C19orf10-CHAF1A

check button Fusion gene summary
Fusion gene informationFusion gene name: C19orf10-CHAF1A
Fusion gene ID: hg56005tg10036
HgeneTgene
Gene symbol

C19orf10

CHAF1A

Gene ID

56005

10036

Gene namemyeloid derived growth factorchromatin assembly factor 1 subunit A
SynonymsC19orf10|EUROIMAGE1875335|IL25|IL27|IL27w|R33729_1|SF20CAF-1|CAF1|CAF1B|CAF1P150|P150
Cytomap('C19orf10')('CHAF1A')

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionmyeloid-derived growth factorUPF0556 protein C19orf10interleukin 27 working designationinterleukin-25stromal cell-derived growth factor SF20chromatin assembly factor 1 subunit ACAF-1 subunit ACAF-I 150 kDa subunitCAF-I p150CTB-50L17.7chromatin assembly factor I (150 kDa)chromatin assembly factor I p150 subunithp150
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262947, ENST00000599630, 
Fusion gene scores* DoF score4 X 4 X 4=645 X 6 X 6=180
# samples 57
** MAII scorelog2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C19orf10 [Title/Abstract] AND CHAF1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC19orf10(4668607)-CHAF1A(4422563), # samples:1
Anticipated loss of major functional domain due to fusion event.C19orf10-CHAF1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C19orf10-CHAF1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C19orf10-CHAF1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C19orf10-CHAF1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneC19orf10

GO:0001938

positive regulation of endothelial cell proliferation

25581518

HgeneC19orf10

GO:0045766

positive regulation of angiogenesis

25581518

TgeneCHAF1A

GO:0006335

DNA replication-dependent nucleosome assembly

14718166

TgeneCHAF1A

GO:0031497

chromatin assembly

8858152


check buttonFusion gene breakpoints across C19orf10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CHAF1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GH-01AC19orf10chr19

4668607

-CHAF1Achr19

4422563

+


Top

Fusion Gene ORF analysis for C19orf10-CHAF1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262947ENST00000587368C19orf10chr19

4668607

-CHAF1Achr19

4422563

+
5CDS-intronENST00000599630ENST00000587368C19orf10chr19

4668607

-CHAF1Achr19

4422563

+
In-frameENST00000262947ENST00000301280C19orf10chr19

4668607

-CHAF1Achr19

4422563

+
In-frameENST00000599630ENST00000301280C19orf10chr19

4668607

-CHAF1Achr19

4422563

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000262947C19orf10chr194668607-ENST00000301280CHAF1Achr194422563+2482261362114692
ENST00000599630C19orf10chr194668607-ENST00000301280CHAF1Achr194422563+2474253282106692

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262947ENST00000301280C19orf10chr194668607-CHAF1Achr194422563+0.0122715770.9877285
ENST00000599630ENST00000301280C19orf10chr194668607-CHAF1Achr194422563+0.0125474020.98745257

Top

Fusion Genomic Features for C19orf10-CHAF1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C19orf10chr194668606-CHAF1Achr194422562+6.04E-121
C19orf10chr194668606-CHAF1Achr194422562+6.04E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for C19orf10-CHAF1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:4668607/chr19:4422563)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCHAF1Achr19:4668607chr19:4422563ENST00000301280315602_608339957.0Compositional biasNote=Poly-Glu
TgeneCHAF1Achr19:4668607chr19:4422563ENST00000301280315619_623339957.0Compositional biasNote=Poly-Asp
TgeneCHAF1Achr19:4668607chr19:4422563ENST00000301280315905_911339957.0Compositional biasNote=Poly-Glu
TgeneCHAF1Achr19:4668607chr19:4422563ENST00000301280315642_678339957.0RegionNote=Necessary for homodimerization and competence for chromatin assembly
TgeneCHAF1Achr19:4668607chr19:4422563ENST00000301280315660_956339957.0RegionNote=Binds to p60

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCHAF1Achr19:4668607chr19:4422563ENST00000301280315323_453339957.0Compositional biasNote=Arg/Glu/Lys-rich
TgeneCHAF1Achr19:4668607chr19:4422563ENST00000301280315233_246339957.0MotifNote=PxVxL motif
TgeneCHAF1Achr19:4668607chr19:4422563ENST000003012803151_314339957.0RegionNote=Binds to CBX1 chromo shadow domain
TgeneCHAF1Achr19:4668607chr19:4422563ENST000003012803151_49339957.0RegionNote=Binds to PCNA


Top

Fusion Gene Sequence for C19orf10-CHAF1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11153_11153_1_C19orf10-CHAF1A_C19orf10_chr19_4668607_ENST00000262947_CHAF1A_chr19_4422563_ENST00000301280_length(transcript)=2482nt_BP=261nt
GTCTACCCGCCCCTGCCCTGAGGACCCTAGTCCAACATGGCGGCGCCCAGCGGAGGGTGGAACGGCGTCGGCGCGAGCTTGTGGGCCGCG
CTGCTCCTAGGGGCCGTGGCGCTGAGGCCGGCGGAGGCGGTGTCCGAGCCCACGACGGTGGCGTTTGACGTGCGGCCCGGCGGCGTCGTG
CATTCCTTCTCCCATAACGTGGGCCCGGGGGACAAATATACGTGTATGTTCACTTACGCCTCTCAAGGAGGGACCAATGAGGATCAGGAG
CGTCTGGGCAAGCAGCTCAAGTTACGTGCAGAAAGGGAAGAAAAGGAGAAGCTGAAAGAGGAGGCCAAGCGGGCCAAGGAGGAGGCCAAG
AAGAAGAAGGAGGAAGAGAAGGAGCTTAAGGAAAAGGAGAGGCGGGAGAAGCGGGAGAAGGATGAGAAGGAGAAGGCGGAGAAGCAGCGG
CTCAAGGAGGAGCGGCGCAAGGAGAGACAGGAAGCCCTGGAGGCTAAACTTGAGGAAAAAAGGAAAAAGGAAGAAGAGAAACGGTTAAGA
GAAGAAGAGAAGCGCATTAAAGCAGAGAAGGCCGAAATCACGAGGTTCTTCCAGAAACCAAAGACTCCACAGGCCCCCAAGACCCTGGCC
GGCTCCTGTGGGAAGTTTGCCCCCTTTGAAATTAAAGAGCACATGGTCCTGGCCCCTCGGCGTCGGACCGCTTTCCATCCAGACCTCTGC
AGTCAGCTGGACCAGCTCCTCCAGCAGCAGAGCGGCGAGTTCTCCTTCTTGAAAGACCTCAAAGGCCGGCAGCCCCTGAGGTCCGGACCC
ACGCACGTTTCCACCCGGAATGCAGATATTTTTAACAGTGATGTCGTCATCGTGGAGCGTGGGAAGGGCGACGGTGTTCCCGAGAGGAGG
AAGTTTGGCAGGATGAAGCTCCTGCAGTTCTGTGAGAACCACCGGCCTGCCTACTGGGGTACCTGGAATAAGAAGACGGCACTCATCCGC
GCGCGAGACCCCTGGGCCCAGGACACGAAGCTCCTGGACTATGAGGTGGACAGTGATGAGGAGTGGGAAGAAGAGGAGCCTGGGGAGTCC
CTGTCCCACAGTGAGGGGGATGATGATGACGACATGGGAGAGGATGAAGATGAGGACGATGGTTTCTTTGTGCCCCATGGGTACCTGTCT
GAGGACGAAGGTGTGACAGAGGAGTGTGCCGACCCTGAGAACCATAAGGTCCGCCAGAAACTGAAGGCCAAGGAGTGGGACGAGTTCCTG
GCTAAGGGGAAGCGCTTTCGCGTCCTGCAACCTGTGAAGATCGGCTGCGTGTGGGCGGCTGACAGAGACTGCGCAGGCGATGACCTGAAG
GTACTGCAGCAGTTCGCAGCCTGCTTCCTGGAGACCCTGCCGGCCCAGGAGGAGCAGACGCCCAAGGCCTCCAAGCGGGAGAGGAGAGAC
GAGCAGATCCTGGCCCAGCTGCTGCCGCTCCTGCACGGCAATGTGAACGGGAGCAAGGTCATCATCCGGGAGTTCCAGGAGCACTGCCGC
CGGGGACTGCTCAGCAACCACACCGGCAGCCCGCGGAGCCCCTCCACCACCTACCTGCACACCCCCACCCCCAGCGAGGATGCCGCCATC
CCCTCTAAGTCCCGGCTCAAGCGGCTCATTTCCGAGAACTCAGTGTATGAGAAGCGGCCTGACTTCAGGATGTGCTGGTACGTGCACCCG
CAGGTGCTACAGAGCTTCCAGCAGGAGCACCTGCCCGTGCCGTGCCAGTGGAGCTATGTGACATCGGTGCCCTCGGCCCCCAAAGAGGAC
AGTGGCAGCGTCCCCTCCACGGGGCCCAGCCAGGGCACTCCCATCTCGCTGAAGAGGAAGTCAGCGGGCAGCATGTGCATCACCCAATTC
ATGAAGAAGCGCAGGCACGACGGCCAGATTGGTGCTGAAGACATGGACGGCTTCCAGGCAGACACGGAGGAGGAGGAAGAGGAGGAGGGC
GACTGTATGATCGTGGATGTCCCGGATGCTGCGGAGGTCCAAGCCCCGTGTGGAGCCGCTTCCGGAGCTGGGGGTGGTGTGGGGGTGGAC
ACCGGCAAGGCCACCCTGACCTCGAGCCCACTGGGTGCATCCTGAGAGCAGGGGTGACGTATGTAGAATGCTTAGGGTGTCCTCCCCACA
GAGCAGATACTTGAACCGACTCAATTCCTGTGTAAAGAGCACTTTGTCCTGCTTCACGGACCTCCCCAAAGTGTGCAGAGTTCTATATAG
GATGCTGGATTAGTTCCTTTGATATTTGTAAAAATTCCCCCAAGAGCCGCATATGAATCTGCCCTTTAATAAAGCATTATTGAGATTGCT
GGCCTATTGGGGAAGCCTGCGGGCACAGGAGCAGGCGTGGAATCCAATACTTGTAAATGAATTGAAGCGTCAGGACCACCCGCCTGGCCA

>11153_11153_1_C19orf10-CHAF1A_C19orf10_chr19_4668607_ENST00000262947_CHAF1A_chr19_4422563_ENST00000301280_length(amino acids)=692AA_BP=0
MAAPSGGWNGVGASLWAALLLGAVALRPAEAVSEPTTVAFDVRPGGVVHSFSHNVGPGDKYTCMFTYASQGGTNEDQERLGKQLKLRAER
EEKEKLKEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAE
ITRFFQKPKTPQAPKTLAGSCGKFAPFEIKEHMVLAPRRRTAFHPDLCSQLDQLLQQQSGEFSFLKDLKGRQPLRSGPTHVSTRNADIFN
SDVVIVERGKGDGVPERRKFGRMKLLQFCENHRPAYWGTWNKKTALIRARDPWAQDTKLLDYEVDSDEEWEEEEPGESLSHSEGDDDDDM
GEDEDEDDGFFVPHGYLSEDEGVTEECADPENHKVRQKLKAKEWDEFLAKGKRFRVLQPVKIGCVWAADRDCAGDDLKVLQQFAACFLET
LPAQEEQTPKASKRERRDEQILAQLLPLLHGNVNGSKVIIREFQEHCRRGLLSNHTGSPRSPSTTYLHTPTPSEDAAIPSKSRLKRLISE
NSVYEKRPDFRMCWYVHPQVLQSFQQEHLPVPCQWSYVTSVPSAPKEDSGSVPSTGPSQGTPISLKRKSAGSMCITQFMKKRRHDGQIGA

--------------------------------------------------------------
>11153_11153_2_C19orf10-CHAF1A_C19orf10_chr19_4668607_ENST00000599630_CHAF1A_chr19_4422563_ENST00000301280_length(transcript)=2474nt_BP=253nt
GCCCCTGCCCTGAGGACCCTAGTCCAACATGGCGGCGCCCAGCGGAGGGTGGAACGGCGTCGGCGCGAGCTTGTGGGCCGCGCTGCTCCT
AGGGGCCGTGGCGCTGAGGCCGGCGGAGGCGGTGTCCGAGCCCACGACGGTGGCGTTTGACGTGCGGCCCGGCGGCGTCGTGCATTCCTT
CTCCCATAACGTGGGCCCGGGGGACAAATATACGTGTATGTTCACTTACGCCTCTCAAGGAGGGACCAATGAGGATCAGGAGCGTCTGGG
CAAGCAGCTCAAGTTACGTGCAGAAAGGGAAGAAAAGGAGAAGCTGAAAGAGGAGGCCAAGCGGGCCAAGGAGGAGGCCAAGAAGAAGAA
GGAGGAAGAGAAGGAGCTTAAGGAAAAGGAGAGGCGGGAGAAGCGGGAGAAGGATGAGAAGGAGAAGGCGGAGAAGCAGCGGCTCAAGGA
GGAGCGGCGCAAGGAGAGACAGGAAGCCCTGGAGGCTAAACTTGAGGAAAAAAGGAAAAAGGAAGAAGAGAAACGGTTAAGAGAAGAAGA
GAAGCGCATTAAAGCAGAGAAGGCCGAAATCACGAGGTTCTTCCAGAAACCAAAGACTCCACAGGCCCCCAAGACCCTGGCCGGCTCCTG
TGGGAAGTTTGCCCCCTTTGAAATTAAAGAGCACATGGTCCTGGCCCCTCGGCGTCGGACCGCTTTCCATCCAGACCTCTGCAGTCAGCT
GGACCAGCTCCTCCAGCAGCAGAGCGGCGAGTTCTCCTTCTTGAAAGACCTCAAAGGCCGGCAGCCCCTGAGGTCCGGACCCACGCACGT
TTCCACCCGGAATGCAGATATTTTTAACAGTGATGTCGTCATCGTGGAGCGTGGGAAGGGCGACGGTGTTCCCGAGAGGAGGAAGTTTGG
CAGGATGAAGCTCCTGCAGTTCTGTGAGAACCACCGGCCTGCCTACTGGGGTACCTGGAATAAGAAGACGGCACTCATCCGCGCGCGAGA
CCCCTGGGCCCAGGACACGAAGCTCCTGGACTATGAGGTGGACAGTGATGAGGAGTGGGAAGAAGAGGAGCCTGGGGAGTCCCTGTCCCA
CAGTGAGGGGGATGATGATGACGACATGGGAGAGGATGAAGATGAGGACGATGGTTTCTTTGTGCCCCATGGGTACCTGTCTGAGGACGA
AGGTGTGACAGAGGAGTGTGCCGACCCTGAGAACCATAAGGTCCGCCAGAAACTGAAGGCCAAGGAGTGGGACGAGTTCCTGGCTAAGGG
GAAGCGCTTTCGCGTCCTGCAACCTGTGAAGATCGGCTGCGTGTGGGCGGCTGACAGAGACTGCGCAGGCGATGACCTGAAGGTACTGCA
GCAGTTCGCAGCCTGCTTCCTGGAGACCCTGCCGGCCCAGGAGGAGCAGACGCCCAAGGCCTCCAAGCGGGAGAGGAGAGACGAGCAGAT
CCTGGCCCAGCTGCTGCCGCTCCTGCACGGCAATGTGAACGGGAGCAAGGTCATCATCCGGGAGTTCCAGGAGCACTGCCGCCGGGGACT
GCTCAGCAACCACACCGGCAGCCCGCGGAGCCCCTCCACCACCTACCTGCACACCCCCACCCCCAGCGAGGATGCCGCCATCCCCTCTAA
GTCCCGGCTCAAGCGGCTCATTTCCGAGAACTCAGTGTATGAGAAGCGGCCTGACTTCAGGATGTGCTGGTACGTGCACCCGCAGGTGCT
ACAGAGCTTCCAGCAGGAGCACCTGCCCGTGCCGTGCCAGTGGAGCTATGTGACATCGGTGCCCTCGGCCCCCAAAGAGGACAGTGGCAG
CGTCCCCTCCACGGGGCCCAGCCAGGGCACTCCCATCTCGCTGAAGAGGAAGTCAGCGGGCAGCATGTGCATCACCCAATTCATGAAGAA
GCGCAGGCACGACGGCCAGATTGGTGCTGAAGACATGGACGGCTTCCAGGCAGACACGGAGGAGGAGGAAGAGGAGGAGGGCGACTGTAT
GATCGTGGATGTCCCGGATGCTGCGGAGGTCCAAGCCCCGTGTGGAGCCGCTTCCGGAGCTGGGGGTGGTGTGGGGGTGGACACCGGCAA
GGCCACCCTGACCTCGAGCCCACTGGGTGCATCCTGAGAGCAGGGGTGACGTATGTAGAATGCTTAGGGTGTCCTCCCCACAGAGCAGAT
ACTTGAACCGACTCAATTCCTGTGTAAAGAGCACTTTGTCCTGCTTCACGGACCTCCCCAAAGTGTGCAGAGTTCTATATAGGATGCTGG
ATTAGTTCCTTTGATATTTGTAAAAATTCCCCCAAGAGCCGCATATGAATCTGCCCTTTAATAAAGCATTATTGAGATTGCTGGCCTATT
GGGGAAGCCTGCGGGCACAGGAGCAGGCGTGGAATCCAATACTTGTAAATGAATTGAAGCGTCAGGACCACCCGCCTGGCCACGTGCGCG

>11153_11153_2_C19orf10-CHAF1A_C19orf10_chr19_4668607_ENST00000599630_CHAF1A_chr19_4422563_ENST00000301280_length(amino acids)=692AA_BP=0
MAAPSGGWNGVGASLWAALLLGAVALRPAEAVSEPTTVAFDVRPGGVVHSFSHNVGPGDKYTCMFTYASQGGTNEDQERLGKQLKLRAER
EEKEKLKEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAE
ITRFFQKPKTPQAPKTLAGSCGKFAPFEIKEHMVLAPRRRTAFHPDLCSQLDQLLQQQSGEFSFLKDLKGRQPLRSGPTHVSTRNADIFN
SDVVIVERGKGDGVPERRKFGRMKLLQFCENHRPAYWGTWNKKTALIRARDPWAQDTKLLDYEVDSDEEWEEEEPGESLSHSEGDDDDDM
GEDEDEDDGFFVPHGYLSEDEGVTEECADPENHKVRQKLKAKEWDEFLAKGKRFRVLQPVKIGCVWAADRDCAGDDLKVLQQFAACFLET
LPAQEEQTPKASKRERRDEQILAQLLPLLHGNVNGSKVIIREFQEHCRRGLLSNHTGSPRSPSTTYLHTPTPSEDAAIPSKSRLKRLISE
NSVYEKRPDFRMCWYVHPQVLQSFQQEHLPVPCQWSYVTSVPSAPKEDSGSVPSTGPSQGTPISLKRKSAGSMCITQFMKKRRHDGQIGA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for C19orf10-CHAF1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for C19orf10-CHAF1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for C19orf10-CHAF1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0026636Mouth Diseases1CTD_human