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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EMC7-CD27 (FusionGDB2 ID:HG56851TG939)

Fusion Gene Summary for EMC7-CD27

check button Fusion gene summary
Fusion gene informationFusion gene name: EMC7-CD27
Fusion gene ID: hg56851tg939
HgeneTgene
Gene symbol

EMC7

CD27

Gene ID

56851

939

Gene nameER membrane protein complex subunit 7CD27 molecule
SynonymsC11orf3|C15orf24|HT022|ORF1-FL1S152|S152. LPFS2|T14|TNFRSF7|Tp55
Cytomap('C15orf24','EMC7')('CD27','CD27')

15q14

12p13.31

Type of geneprotein-codingprotein-coding
DescriptionER membrane protein complex subunit 7UPF0480 protein C15orf24chromosome 15 hypothetical ATG/GTP binding proteinCD27 antigenCD27L receptorT cell activation antigen S152T-cell activation antigen CD27tumor necrosis factor receptor superfamily, member 7
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000256545, ENST00000532113, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 4 X 3=36
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EMC7 [Title/Abstract] AND CD27 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC15orf24(34388095)-CD27(6554589), # samples:1
C15orf24(34388096)-CD27(6554590), # samples:1
EMC7(34388096)-CD27(6554590), # samples:2
Anticipated loss of major functional domain due to fusion event.EMC7-CD27 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EMC7-CD27 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCD27

GO:0043066

negative regulation of apoptotic process

12324477

TgeneCD27

GO:0097191

extrinsic apoptotic signaling pathway

9177220



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-X6-A8C6-01AC15orf24chr15

34388096

-CD27chr12

6554590

+
ChimerDB4SARCTCGA-X6-A8C6-01AEMC7chr15

34388096

-CD27chr12

6554590

+
ChimerDB4SARCTCGA-X6-A8C6-01AEMC7chr15

34388096

-CD27chr12

6559339

+
ChimerDB4SARCTCGA-X6-A8C6-01AEMC7chr15

34388096

-CD27chr12

6559707

+
ChimerDB4SARCTCGA-X6-A8C6C15orf24chr15

34388095

-CD27chr12

6554589

+


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Fusion Gene ORF analysis for EMC7-CD27

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000256545ENST00000541233EMC7chr15

34388096

-CD27chr12

6554590

+
5CDS-3UTRENST00000256545ENST00000541233EMC7chr15

34388096

-CD27chr12

6559339

+
5CDS-3UTRENST00000256545ENST00000541233EMC7chr15

34388096

-CD27chr12

6559707

+
Frame-shiftENST00000256545ENST00000266557EMC7chr15

34388096

-CD27chr12

6554590

+
Frame-shiftENST00000256545ENST00000266557EMC7chr15

34388096

-CD27chr12

6559339

+
Frame-shiftENST00000256545ENST00000266557EMC7chr15

34388096

-CD27chr12

6559707

+
intron-3CDSENST00000532113ENST00000266557EMC7chr15

34388096

-CD27chr12

6554590

+
intron-3CDSENST00000532113ENST00000266557EMC7chr15

34388096

-CD27chr12

6559339

+
intron-3CDSENST00000532113ENST00000266557EMC7chr15

34388096

-CD27chr12

6559707

+
intron-3UTRENST00000532113ENST00000541233EMC7chr15

34388096

-CD27chr12

6554590

+
intron-3UTRENST00000532113ENST00000541233EMC7chr15

34388096

-CD27chr12

6559339

+
intron-3UTRENST00000532113ENST00000541233EMC7chr15

34388096

-CD27chr12

6559707

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for EMC7-CD27


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EMC7chr1534388095-CD27chr126559338+2.18E-070.99999976
EMC7chr1534388095-CD27chr126554589+1.02E-081
EMC7chr1534388095-CD27chr126559706+2.50E-081
EMC7chr1534388095-CD27chr126559338+2.18E-070.99999976
EMC7chr1534388095-CD27chr126554589+1.02E-081
EMC7chr1534388095-CD27chr126559706+2.50E-081


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EMC7-CD27


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:34388095/:6554589)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EMC7-CD27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EMC7-CD27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EMC7-CD27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EMC7-CD27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC3554540LYMPHOPROLIFERATIVE SYNDROME 23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0006625Cachexia1CTD_human
TgeneC0494261Combined immunodeficiency1GENOMICS_ENGLAND