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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADAMTS9-CHL1 (FusionGDB2 ID:HG56999TG10752)

Fusion Gene Summary for ADAMTS9-CHL1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAMTS9-CHL1
Fusion gene ID: hg56999tg10752
HgeneTgene
Gene symbol

ADAMTS9

CHL1

Gene ID

56999

10752

Gene nameADAM metallopeptidase with thrombospondin type 1 motif 9cell adhesion molecule L1 like
Synonyms-CALL|L1CAM2
Cytomap('ADAMTS9')('CHL1')

3p14.1

3p26.3

Type of geneprotein-codingprotein-coding
DescriptionA disintegrin and metalloproteinase with thrombospondin motifs 9a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9neural cell adhesion molecule L1-like proteinL1 cell adhesion molecule 2cell adhesion molecule with homology to L1CAM (close homolog of L1)cell adhesion molecule with homology to L1CAM (close homologue of L1)close homolog of L1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000295903, ENST00000498707, 
ENST00000459780, ENST00000467257, 
Fusion gene scores* DoF score7 X 7 X 5=2455 X 7 X 4=140
# samples 76
** MAII scorelog2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/140*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAMTS9 [Title/Abstract] AND CHL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAMTS9(64619374)-CHL1(447178), # samples:1
Anticipated loss of major functional domain due to fusion event.ADAMTS9-CHL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS9-CHL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS9-CHL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS9-CHL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS9-CHL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ADAMTS9-CHL1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ADAMTS9-CHL1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ADAMTS9-CHL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAMTS9

GO:0006508

proteolysis

12514189


check buttonFusion gene breakpoints across ADAMTS9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CHL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-62-8395-01AADAMTS9chr3

64619374

-CHL1chr3

447178

+


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Fusion Gene ORF analysis for ADAMTS9-CHL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000295903ENST00000489224ADAMTS9chr3

64619374

-CHL1chr3

447178

+
5CDS-intronENST00000498707ENST00000489224ADAMTS9chr3

64619374

-CHL1chr3

447178

+
Frame-shiftENST00000295903ENST00000256509ADAMTS9chr3

64619374

-CHL1chr3

447178

+
Frame-shiftENST00000498707ENST00000256509ADAMTS9chr3

64619374

-CHL1chr3

447178

+
In-frameENST00000295903ENST00000397491ADAMTS9chr3

64619374

-CHL1chr3

447178

+
In-frameENST00000498707ENST00000397491ADAMTS9chr3

64619374

-CHL1chr3

447178

+
intron-3CDSENST00000459780ENST00000256509ADAMTS9chr3

64619374

-CHL1chr3

447178

+
intron-3CDSENST00000459780ENST00000397491ADAMTS9chr3

64619374

-CHL1chr3

447178

+
intron-3CDSENST00000467257ENST00000256509ADAMTS9chr3

64619374

-CHL1chr3

447178

+
intron-3CDSENST00000467257ENST00000397491ADAMTS9chr3

64619374

-CHL1chr3

447178

+
intron-intronENST00000459780ENST00000489224ADAMTS9chr3

64619374

-CHL1chr3

447178

+
intron-intronENST00000467257ENST00000489224ADAMTS9chr3

64619374

-CHL1chr3

447178

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000295903ADAMTS9chr364619374-ENST00000397491CHL1chr3447178+33341976222058678
ENST00000498707ADAMTS9chr364619374-ENST00000397491CHL1chr3447178+373923813432463706

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000295903ENST00000397491ADAMTS9chr364619374-CHL1chr3447178+0.0015061270.9984939
ENST00000498707ENST00000397491ADAMTS9chr364619374-CHL1chr3447178+0.0015063830.99849355

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Fusion Genomic Features for ADAMTS9-CHL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ADAMTS9chr364619373-CHL1chr3447177+0.017136410.9828636
ADAMTS9chr364619373-CHL1chr3447177+0.017136410.9828636

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ADAMTS9-CHL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:64619374/chr3:447178)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-123988_966512196.6666666666665Compositional biasNote=Poly-Ser
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-134088_966792117.3333333333335Compositional biasNote=Poly-Ser
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-1239293_4996512196.6666666666665DomainPeptidase M12B
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-1239509_5876512196.6666666666665DomainNote=Disintegrin
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-1239588_6436512196.6666666666665DomainTSP type-1 1
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-1340293_4996792117.3333333333335DomainPeptidase M12B
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-1340509_5876792117.3333333333335DomainNote=Disintegrin
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-1340588_6436792117.3333333333335DomainTSP type-1 1
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-1239221_2286512196.6666666666665MotifCysteine switch
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-1340221_2286792117.3333333333335MotifCysteine switch
TgeneCHL1chr3:64619374chr3:447178ENST0000025650926281181_118511521225.0MotifNote=FIG[AQ]Y
TgeneCHL1chr3:64619374chr3:447178ENST0000039749125271181_118511361209.0MotifNote=FIG[AQ]Y

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-1239644_7526512196.6666666666665Compositional biasNote=Cys-rich
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-1340644_7526792117.3333333333335Compositional biasNote=Cys-rich
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-12391052_11096512196.6666666666665DomainTSP type-1 5
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-12391110_11666512196.6666666666665DomainTSP type-1 6
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-12391182_12406512196.6666666666665DomainTSP type-1 7
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-12391241_12966512196.6666666666665DomainTSP type-1 8
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-12391328_13796512196.6666666666665DomainTSP type-1 9
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-12391382_14406512196.6666666666665DomainTSP type-1 10
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-12391441_14946512196.6666666666665DomainTSP type-1 11
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-12391497_15556512196.6666666666665DomainTSP type-1 12
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-12391556_16116512196.6666666666665DomainTSP type-1 13
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-12391612_16766512196.6666666666665DomainTSP type-1 14
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-12391677_17346512196.6666666666665DomainTSP type-1 15
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-12391735_19356512196.6666666666665DomainGON
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-1239878_9366512196.6666666666665DomainTSP type-1 2
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-1239939_9976512196.6666666666665DomainTSP type-1 3
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-1239998_10496512196.6666666666665DomainTSP type-1 4
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-13401052_11096792117.3333333333335DomainTSP type-1 5
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-13401110_11666792117.3333333333335DomainTSP type-1 6
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-13401182_12406792117.3333333333335DomainTSP type-1 7
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-13401241_12966792117.3333333333335DomainTSP type-1 8
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-13401328_13796792117.3333333333335DomainTSP type-1 9
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-13401382_14406792117.3333333333335DomainTSP type-1 10
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-13401441_14946792117.3333333333335DomainTSP type-1 11
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-13401497_15556792117.3333333333335DomainTSP type-1 12
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-13401556_16116792117.3333333333335DomainTSP type-1 13
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-13401612_16766792117.3333333333335DomainTSP type-1 14
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-13401677_17346792117.3333333333335DomainTSP type-1 15
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-13401735_19356792117.3333333333335DomainGON
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-1340878_9366792117.3333333333335DomainTSP type-1 2
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-1340939_9976792117.3333333333335DomainTSP type-1 3
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-1340998_10496792117.3333333333335DomainTSP type-1 4
HgeneADAMTS9chr3:64619374chr3:447178ENST00000295903-1239753_8776512196.6666666666665RegionNote=Spacer
HgeneADAMTS9chr3:64619374chr3:447178ENST00000498707-1340753_8776792117.3333333333335RegionNote=Spacer
TgeneCHL1chr3:64619374chr3:447178ENST000002565092628128_22311521225.0DomainNote=Ig-like C2-type 2
TgeneCHL1chr3:64619374chr3:447178ENST000002565092628235_32811521225.0DomainNote=Ig-like C2-type 3
TgeneCHL1chr3:64619374chr3:447178ENST000002565092628331_41711521225.0DomainNote=Ig-like C2-type 4
TgeneCHL1chr3:64619374chr3:447178ENST00000256509262835_12411521225.0DomainNote=Ig-like C2-type 1
TgeneCHL1chr3:64619374chr3:447178ENST000002565092628423_51011521225.0DomainNote=Ig-like C2-type 5
TgeneCHL1chr3:64619374chr3:447178ENST000002565092628515_60711521225.0DomainNote=Ig-like C2-type 6
TgeneCHL1chr3:64619374chr3:447178ENST000002565092628614_70911521225.0DomainFibronectin type-III 1
TgeneCHL1chr3:64619374chr3:447178ENST000002565092628714_80711521225.0DomainFibronectin type-III 2
TgeneCHL1chr3:64619374chr3:447178ENST000002565092628809_91411521225.0DomainFibronectin type-III 3
TgeneCHL1chr3:64619374chr3:447178ENST000002565092628918_101511521225.0DomainFibronectin type-III 4
TgeneCHL1chr3:64619374chr3:447178ENST000003974912527128_22311361209.0DomainNote=Ig-like C2-type 2
TgeneCHL1chr3:64619374chr3:447178ENST000003974912527235_32811361209.0DomainNote=Ig-like C2-type 3
TgeneCHL1chr3:64619374chr3:447178ENST000003974912527331_41711361209.0DomainNote=Ig-like C2-type 4
TgeneCHL1chr3:64619374chr3:447178ENST00000397491252735_12411361209.0DomainNote=Ig-like C2-type 1
TgeneCHL1chr3:64619374chr3:447178ENST000003974912527423_51011361209.0DomainNote=Ig-like C2-type 5
TgeneCHL1chr3:64619374chr3:447178ENST000003974912527515_60711361209.0DomainNote=Ig-like C2-type 6
TgeneCHL1chr3:64619374chr3:447178ENST000003974912527614_70911361209.0DomainFibronectin type-III 1
TgeneCHL1chr3:64619374chr3:447178ENST000003974912527714_80711361209.0DomainFibronectin type-III 2
TgeneCHL1chr3:64619374chr3:447178ENST000003974912527809_91411361209.0DomainFibronectin type-III 3
TgeneCHL1chr3:64619374chr3:447178ENST000003974912527918_101511361209.0DomainFibronectin type-III 4
TgeneCHL1chr3:64619374chr3:447178ENST000002565092628555_55811521225.0MotifNote=DGEA
TgeneCHL1chr3:64619374chr3:447178ENST000003974912527555_55811361209.0MotifNote=DGEA
TgeneCHL1chr3:64619374chr3:447178ENST0000025650926281104_120811521225.0Topological domainCytoplasmic
TgeneCHL1chr3:64619374chr3:447178ENST00000256509262825_108211521225.0Topological domainExtracellular
TgeneCHL1chr3:64619374chr3:447178ENST0000039749125271104_120811361209.0Topological domainCytoplasmic
TgeneCHL1chr3:64619374chr3:447178ENST00000397491252725_108211361209.0Topological domainExtracellular
TgeneCHL1chr3:64619374chr3:447178ENST0000025650926281083_110311521225.0TransmembraneHelical
TgeneCHL1chr3:64619374chr3:447178ENST0000039749125271083_110311361209.0TransmembraneHelical


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Fusion Gene Sequence for ADAMTS9-CHL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2112_2112_1_ADAMTS9-CHL1_ADAMTS9_chr3_64619374_ENST00000295903_CHL1_chr3_447178_ENST00000397491_length(transcript)=3334nt_BP=1976nt
GGAGGGAGGGGTGGGAAGCACCATGCAGTTTGTATCCTGGGCCACACTGCTAACGCTCCTGGTGCGGGACCTGGCCGAGATGGGGAGCCC
AGACGCCGCGGCGGCCGTGCGCAAGGACAGGCTGCACCCGAGGCAAGTGAAATTATTAGAGACCCTGAGCGAATACGAAATCGTGTCTCC
CATCCGAGTGAACGCTCTCGGAGAACCCTTTCCCACGAACGTCCACTTCAAAAGAACGCGACGGAGCATTAACTCTGCCACTGACCCCTG
GCCTGCCTTCGCCTCCTCCTCTTCCTCCTCTACCTCCTCCCAGGCGCATTACCGCCTCTCTGCCTTCGGCCAGCAGTTTCTATTTAATCT
CACCGCCAATGCCGGATTTATCGCTCCACTGTTCACTGTCACCCTCCTCGGGACGCCCGGGGTGAATCAGACCAAGTTTTATTCCGAAGA
GGAAGCGGAACTCAAGCACTGTTTCTACAAAGGCTATGTCAATACCAACTCCGAGCACACGGCCGTCATCAGCCTCTGCTCAGGAATGCT
GGGCACATTCCGGTCTCATGATGGGGATTATTTTATTGAACCACTACAGTCTATGGATGAACAAGAAGATGAAGAGGAACAAAACAAACC
CCACATCATTTATAGGCGCAGCGCCCCCCAGAGAGAGCCCTCAACAGGAAGGCATGCATGTGACACCTCAGAACACAAAAATAGGCACAG
TAAAGACAAGAAGAAAACCAGAGCAAGAAAATGGGGAGAAAGGATTAACCTGGCTGGTGACGTAGCAGCATTAAACAGCGGCTTAGCAAC
AGAGGCATTTTCTGCTTATGGTAATAAGACGGACAACACAAGAGAAAAGAGGACCCACAGAAGGACAAAACGTTTTTTATCCTATCCACG
GTTTGTAGAAGTCTTGGTGGTGGCAGACAACAGAATGGTTTCATACCATGGAGAAAACCTTCAACACTATATTTTAACTTTAATGTCAAT
TGATGGGCCTTCCATATCTTTTAATGCTCAGACAACATTAAAAAACTTTTGCCAGTGGCAGCATTCGAAGAACAGTCCAGGTGGAATCCA
TCATGATACTGCTGTTCTCTTAACAAGACAGGATATCTGCAGAGCTCACGACAAATGTGATACCTTAGGCCTGGCTGAACTGGGAACCAT
TTGTGATCCCTATAGAAGCTGTTCTATTAGTGAAGATAGTGGATTGAGTACAGCTTTTACGATCGCCCATGAGCTGGGCCATGTGTTTAA
CATGCCTCATGATGACAACAACAAATGTAAAGAAGAAGGAGTTAAGAGTCCCCAGCATGTCATGGCTCCAACACTGAACTTCTACACCAA
CCCCTGGATGTGGTCAAAGTGTAGTCGAAAATATATCACTGAGTTTTTAGACACTGGTTATGGCGAGTGTTTGCTTAACGAACCTGAATC
CAGACCCTACCCTTTGCCTGTCCAACTGCCAGGCATCCTTTACAACGTGAATAAACAATGTGAATTGATTTTTGGACCAGGTTCTCAGGT
GTGCCCATATATGATGCAGTGCAGACGGCTCTGGTGCAATAACGTCAATGGAGTACACAAAGGCTGCCGGACTCAGCACACACCCTGGGC
CGATGGGACGGAGTGCGAGCCTGGAAAGCACTGCAAGTATGGATTTTGTGTTCCCAAAGAAATGGATGTCCCCGTGACAGATGGATCCTG
GGGAAGTTGGAGTCCCTTTGGAACCTGCTCCAGAACATGTGGAGGGGGCATCAAAACAGCCATTCGAGAGTGCAACAGACCAGAACCAAA
AAATGGTGGAAAATACTGTGTAGGACGTAGAATGAAATTTAAGTCCTGCAACACGGAGCCATGTCTCAAGCAGAAGCGAGACTTCCGAGA
TGAACAGTGTGCTCACTTTGACGGGAAGCATTTTAACATCAACGGTCTGCTTCCCAATGTGCGCTGGGTCCCTAAATACAGTGGAATGAC
AGTGATGAAAAGCCTCTCAAAGGAAGCCTTCGGTCCCTTAATAGGGATATGCAGCCTACTGAAAGTGCTGACAGCTTAGTCGAATACGGA
GAGGGAGACCATGGTCTCTTCAGTGAAGATGGATCATTTATTGGTGCCTACGCTGGATCTAAGGAGAAGGGATCTGTTGAAAGCAATGGA
AGTTCTACAGCAACTTTTCCCCTTCGGGCATAAACACAACATATGTAAGCAACGCTACTGGTTCACCCCAACCTTCCATATTTATCTGTT
CAAAGGAGCAAGAACTTTCATATAGGAATAGAAACATGCTGGCCGAAGATTTCATCCAGAAGTCAACATCCTGCAATTATGTTGAAAAGA
GTAGTACTTTCTTCAAAATATAAAATGCCAAGCACTTCAGGCCTATGTTTTGCTTATATTGTTTTCAGGTGCTCAAAATGCAAAACACAA
AACAAATCCTGCATTTAGATACACCTCAACTAAATCCAAAGTCCCCATTCAGTATATTCCATATTTGCCTGATTTTACTATTCGGTGTGT
TTGCATAGATGTTGCTACTTGGTGGGTTTTTCTCCGTATGCACATTGGTATACAGTCTCTGAGAACTGGCTTGGTGACTTTGCTTCACTA
CAGGTTAAAAGACCATAAGCAAACTGGTTATTTAAAATGTAAAAAGGAATATGAAAGTCTTATTAAAACACTTCATTGAAAATATACAGT
CTAAATTTATTATTTAAATTTTACTAGCAAAAGTCTTAGGTGAACAATCAACTAGTATTTGTTGAGCTCCTATTTGCCCAGAGATGGTCA
TATTTAAACAGAAGTATACGTTTTTCAGTTTCAACATGAATTTTTTTATTTCTGTCAGTTATGACATCCACAAGCATCACTTTTTGTGTC
TGTTTTTTTTTTTTTTCTTGGACTAAATTCAACTGCATGGAAGCGGTGGTCAGAAGGTTGTTTTATACGAGAACAGGCAGAAAGTGCCCA
TTGTTCAGGATTCTAATAGCTACATCTACTTAATATCTTCATTTCTAAATTGACTGCTTTTACCTTTTTCTCATGTTTATATAATGGTAT
GCTTGCATATATTTCATGAATACATTGTACATATTATGTTAATATTTACACAATTTAAAATATAGATGTGTTTTATTTTGAAGTGAGAAA
ATGAACATTAACAGGCATGTTTGTACAGCTAGAATATATTAGTAAGATACTGTTTTTCGTCATTCCAGAGCTACAACTAATAACACGAGG
TTCCAAAGCTGAAGACTTTGTATAAAGTATTTGGGTTTTGTTCTTGTATTGCTTTCTTTCAACAGTTTCAAAATAAAATATCATATAAAT
ATTG

>2112_2112_1_ADAMTS9-CHL1_ADAMTS9_chr3_64619374_ENST00000295903_CHL1_chr3_447178_ENST00000397491_length(amino acids)=678AA_BP=652
MQFVSWATLLTLLVRDLAEMGSPDAAAAVRKDRLHPRQVKLLETLSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSS
SSSTSSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHD
GDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYG
NKTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIDGPSISFNAQTTLKNFCQWQHSKNSPGGIHHDTAVLL
TRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKC
SRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQHTPWADGTECEP
GKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFD
GKHFNINGLLPNVRWVPKYSGMTVMKSLSKEAFGPLIGICSLLKVLTA

--------------------------------------------------------------
>2112_2112_2_ADAMTS9-CHL1_ADAMTS9_chr3_64619374_ENST00000498707_CHL1_chr3_447178_ENST00000397491_length(transcript)=3739nt_BP=2381nt
ACAGGGCGCCCGGCGCGCCTCGGAGCGCAAGTTCCTCGCCTTCTCCTGCCCGCTCGCTGGGCATTATGCGGCCAAGCAGCCGAGCCCCAG
TCCTCCTCCTCCTCCTGCTCCTCCGGCTCCTCCTGCGGCCCGAGCGGCTCAGCTCTCGGCAGGCGGCGGCGTTGCTCAGCCGAGCGCAGA
CGGGACCCTCGCAGCGAGACCTCAGCGACTCCTAAAGTCAAAAGTTGGCGGCGGGCGCCGGGCTCCGCGCGCTCTCCACGGCCGCTGCCT
CGCGTCGCCGCCGCAGCCAAGGAGGGCAGGAGGGAGGGGGGTGGGGGCAGCGGAGGGAGGGGTGGGAAGCACCATGCAGTTTGTATCCTG
GGCCACACTGCTAACGCTCCTGGTGCGGGACCTGGCCGAGATGGGGAGCCCAGACGCCGCGGCGGCCGTGCGCAAGGACAGGCTGCACCC
GAGGCAAGTGAAATTATTAGAGACCCTGAGCGAATACGAAATCGTGTCTCCCATCCGAGTGAACGCTCTCGGAGAACCCTTTCCCACGAA
CGTCCACTTCAAAAGAACGCGACGGAGCATTAACTCTGCCACTGACCCCTGGCCTGCCTTCGCCTCCTCCTCTTCCTCCTCTACCTCCTC
CCAGGCGCATTACCGCCTCTCTGCCTTCGGCCAGCAGTTTCTATTTAATCTCACCGCCAATGCCGGATTTATCGCTCCACTGTTCACTGT
CACCCTCCTCGGGACGCCCGGGGTGAATCAGACCAAGTTTTATTCCGAAGAGGAAGCGGAACTCAAGCACTGTTTCTACAAAGGCTATGT
CAATACCAACTCCGAGCACACGGCCGTCATCAGCCTCTGCTCAGGAATGCTGGGCACATTCCGGTCTCATGATGGGGATTATTTTATTGA
ACCACTACAGTCTATGGATGAACAAGAAGATGAAGAGGAACAAAACAAACCCCACATCATTTATAGGCGCAGCGCCCCCCAGAGAGAGCC
CTCAACAGGAAGGCATGCATGTGACACCTCAGAACACAAAAATAGGCACAGTAAAGACAAGAAGAAAACCAGAGCAAGAAAATGGGGAGA
AAGGATTAACCTGGCTGGTGACGTAGCAGCATTAAACAGCGGCTTAGCAACAGAGGCATTTTCTGCTTATGGTAATAAGACGGACAACAC
AAGAGAAAAGAGGACCCACAGAAGGACAAAACGTTTTTTATCCTATCCACGGTTTGTAGAAGTCTTGGTGGTGGCAGACAACAGAATGGT
TTCATACCATGGAGAAAACCTTCAACACTATATTTTAACTTTAATGTCAATTGTAGCCTCTATCTATAAAGACCCAAGTATTGGAAATTT
AATTAATATTGTTATTGTGAACTTAATTGTGATTCATAATGAACAGGATGGGCCTTCCATATCTTTTAATGCTCAGACAACATTAAAAAA
CTTTTGCCAGTGGCAGCATTCGAAGAACAGTCCAGGTGGAATCCATCATGATACTGCTGTTCTCTTAACAAGACAGGATATCTGCAGAGC
TCACGACAAATGTGATACCTTAGGCCTGGCTGAACTGGGAACCATTTGTGATCCCTATAGAAGCTGTTCTATTAGTGAAGATAGTGGATT
GAGTACAGCTTTTACGATCGCCCATGAGCTGGGCCATGTGTTTAACATGCCTCATGATGACAACAACAAATGTAAAGAAGAAGGAGTTAA
GAGTCCCCAGCATGTCATGGCTCCAACACTGAACTTCTACACCAACCCCTGGATGTGGTCAAAGTGTAGTCGAAAATATATCACTGAGTT
TTTAGACACTGGTTATGGCGAGTGTTTGCTTAACGAACCTGAATCCAGACCCTACCCTTTGCCTGTCCAACTGCCAGGCATCCTTTACAA
CGTGAATAAACAATGTGAATTGATTTTTGGACCAGGTTCTCAGGTGTGCCCATATATGATGCAGTGCAGACGGCTCTGGTGCAATAACGT
CAATGGAGTACACAAAGGCTGCCGGACTCAGCACACACCCTGGGCCGATGGGACGGAGTGCGAGCCTGGAAAGCACTGCAAGTATGGATT
TTGTGTTCCCAAAGAAATGGATGTCCCCGTGACAGATGGATCCTGGGGAAGTTGGAGTCCCTTTGGAACCTGCTCCAGAACATGTGGAGG
GGGCATCAAAACAGCCATTCGAGAGTGCAACAGACCAGAACCAAAAAATGGTGGAAAATACTGTGTAGGACGTAGAATGAAATTTAAGTC
CTGCAACACGGAGCCATGTCTCAAGCAGAAGCGAGACTTCCGAGATGAACAGTGTGCTCACTTTGACGGGAAGCATTTTAACATCAACGG
TCTGCTTCCCAATGTGCGCTGGGTCCCTAAATACAGTGGAATGACAGTGATGAAAAGCCTCTCAAAGGAAGCCTTCGGTCCCTTAATAGG
GATATGCAGCCTACTGAAAGTGCTGACAGCTTAGTCGAATACGGAGAGGGAGACCATGGTCTCTTCAGTGAAGATGGATCATTTATTGGT
GCCTACGCTGGATCTAAGGAGAAGGGATCTGTTGAAAGCAATGGAAGTTCTACAGCAACTTTTCCCCTTCGGGCATAAACACAACATATG
TAAGCAACGCTACTGGTTCACCCCAACCTTCCATATTTATCTGTTCAAAGGAGCAAGAACTTTCATATAGGAATAGAAACATGCTGGCCG
AAGATTTCATCCAGAAGTCAACATCCTGCAATTATGTTGAAAAGAGTAGTACTTTCTTCAAAATATAAAATGCCAAGCACTTCAGGCCTA
TGTTTTGCTTATATTGTTTTCAGGTGCTCAAAATGCAAAACACAAAACAAATCCTGCATTTAGATACACCTCAACTAAATCCAAAGTCCC
CATTCAGTATATTCCATATTTGCCTGATTTTACTATTCGGTGTGTTTGCATAGATGTTGCTACTTGGTGGGTTTTTCTCCGTATGCACAT
TGGTATACAGTCTCTGAGAACTGGCTTGGTGACTTTGCTTCACTACAGGTTAAAAGACCATAAGCAAACTGGTTATTTAAAATGTAAAAA
GGAATATGAAAGTCTTATTAAAACACTTCATTGAAAATATACAGTCTAAATTTATTATTTAAATTTTACTAGCAAAAGTCTTAGGTGAAC
AATCAACTAGTATTTGTTGAGCTCCTATTTGCCCAGAGATGGTCATATTTAAACAGAAGTATACGTTTTTCAGTTTCAACATGAATTTTT
TTATTTCTGTCAGTTATGACATCCACAAGCATCACTTTTTGTGTCTGTTTTTTTTTTTTTTCTTGGACTAAATTCAACTGCATGGAAGCG
GTGGTCAGAAGGTTGTTTTATACGAGAACAGGCAGAAAGTGCCCATTGTTCAGGATTCTAATAGCTACATCTACTTAATATCTTCATTTC
TAAATTGACTGCTTTTACCTTTTTCTCATGTTTATATAATGGTATGCTTGCATATATTTCATGAATACATTGTACATATTATGTTAATAT
TTACACAATTTAAAATATAGATGTGTTTTATTTTGAAGTGAGAAAATGAACATTAACAGGCATGTTTGTACAGCTAGAATATATTAGTAA
GATACTGTTTTTCGTCATTCCAGAGCTACAACTAATAACACGAGGTTCCAAAGCTGAAGACTTTGTATAAAGTATTTGGGTTTTGTTCTT
GTATTGCTTTCTTTCAACAGTTTCAAAATAAAATATCATATAAATATTG

>2112_2112_2_ADAMTS9-CHL1_ADAMTS9_chr3_64619374_ENST00000498707_CHL1_chr3_447178_ENST00000397491_length(amino acids)=706AA_BP=680
MQFVSWATLLTLLVRDLAEMGSPDAAAAVRKDRLHPRQVKLLETLSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSS
SSSTSSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHD
GDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYG
NKTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNA
QTTLKNFCQWQHSKNSPGGIHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKC
KEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRR
LWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGR
RMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGMTVMKSLSKEAFGPLIGICSLLKVLTA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ADAMTS9-CHL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADAMTS9-CHL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADAMTS9-CHL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADAMTS9C0011860Diabetes Mellitus, Non-Insulin-Dependent2CTD_human
HgeneADAMTS9C1855681Nephronophthisis, familial juvenile1ORPHANET
TgeneC0036341Schizophrenia2CTD_human
TgeneC0015923Fetal Alcohol Syndrome1PSYGENET
TgeneC0020796Profound Mental Retardation1CTD_human
TgeneC0025363Mental Retardation, Psychosocial1CTD_human
TgeneC0917816Mental deficiency1CTD_human
TgeneC2985290Fetal Alcohol Spectrum Disorders1PSYGENET
TgeneC3714756Intellectual Disability1CTD_human