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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PSMD1-ARMC9 (FusionGDB2 ID:HG5707TG80210)

Fusion Gene Summary for PSMD1-ARMC9

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMD1-ARMC9
Fusion gene ID: hg5707tg80210
HgeneTgene
Gene symbol

PSMD1

ARMC9

Gene ID

5707

80210

Gene nameproteasome 26S subunit, non-ATPase 1armadillo repeat containing 9
SynonymsP112|Rpn2|S1ARM|JBTS30|KU-MEL-1|NS21
Cytomap('PSMD1')('ARMC9')

2q37.1

2q37.1

Type of geneprotein-codingprotein-coding
Description26S proteasome non-ATPase regulatory subunit 126S proteasome regulatory subunit RPN226S proteasome regulatory subunit S126S proteasome subunit p112proteasome (prosome, macropain) 26S subunit, non-ATPase, 1lisH domain-containing protein ARMC9armadillo repeat-containing protein 9armadillo/beta-catenin-like repeatsmelanoma/melanocyte specific protein KU-MEL-1melanoma/melanocyte-specific tumor antigen KU-MEL-1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000488354, ENST00000308696, 
ENST00000373635, ENST00000409643, 
ENST00000308696, ENST00000373635, 
ENST00000409643, ENST00000488354, 
Fusion gene scores* DoF score12 X 11 X 10=13208 X 7 X 10=560
# samples 1912
** MAII scorelog2(19/1320*10)=-2.79646660591487
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/560*10)=-2.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PSMD1 [Title/Abstract] AND ARMC9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPSMD1(231951895)-ARMC9(232196505), # samples:2
PSMD1(231951895)-ARMC9(232196504), # samples:2
Anticipated loss of major functional domain due to fusion event.ARMC9-PSMD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARMC9-PSMD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PSMD1-ARMC9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PSMD1-ARMC9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PSMD1-ARMC9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PSMD1-ARMC9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PSMD1-ARMC9 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PSMD1-ARMC9 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PSMD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ARMC9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-2H-A9GQ-01APSMD1chr2

231951895

+ARMC9chr2

232196505

+
ChimerDB4ESCATCGA-2H-A9GQPSMD1chr2

231951895

+ARMC9chr2

232196504

+
ChimerDB4ESCATCGA-2H-A9GQPSMD1chr2

231951895

+ARMC9chr2

232196505

+
ChimerDB4KIRCTCGA-B8-4143-01APSMD1chr2

231951895

+ARMC9chr2

232099937

+
ChimerDB4KIRCTCGA-BP-4331-01APSMD1chr2

232003564

+ARMC9chr2

232196505

+
ChimerDB4STADTCGA-CG-4305-01APSMD1chr2

231948477

+ARMC9chr2

232220510

+


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Fusion Gene ORF analysis for PSMD1-ARMC9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000488354ENST00000349938PSMD1chr2

231951895

+ARMC9chr2

232196505

+
3UTR-3CDSENST00000488354ENST00000349938PSMD1chr2

231951895

+ARMC9chr2

232196504

+
3UTR-3CDSENST00000488354ENST00000349938PSMD1chr2

231951895

+ARMC9chr2

232099937

+
3UTR-3UTRENST00000488354ENST00000483477PSMD1chr2

231951895

+ARMC9chr2

232196505

+
3UTR-3UTRENST00000488354ENST00000483477PSMD1chr2

231951895

+ARMC9chr2

232196504

+
3UTR-3UTRENST00000488354ENST00000483477PSMD1chr2

231951895

+ARMC9chr2

232099937

+
5CDS-3UTRENST00000308696ENST00000483477PSMD1chr2

231951895

+ARMC9chr2

232196505

+
5CDS-3UTRENST00000308696ENST00000483477PSMD1chr2

231951895

+ARMC9chr2

232196504

+
5CDS-3UTRENST00000308696ENST00000483477PSMD1chr2

231951895

+ARMC9chr2

232099937

+
5CDS-3UTRENST00000308696ENST00000483477PSMD1chr2

232003564

+ARMC9chr2

232196505

+
5CDS-3UTRENST00000308696ENST00000483477PSMD1chr2

231948477

+ARMC9chr2

232220510

+
5CDS-3UTRENST00000373635ENST00000483477PSMD1chr2

231951895

+ARMC9chr2

232196505

+
5CDS-3UTRENST00000373635ENST00000483477PSMD1chr2

231951895

+ARMC9chr2

232196504

+
5CDS-3UTRENST00000373635ENST00000483477PSMD1chr2

231951895

+ARMC9chr2

232099937

+
5CDS-3UTRENST00000373635ENST00000483477PSMD1chr2

232003564

+ARMC9chr2

232196505

+
5CDS-3UTRENST00000373635ENST00000483477PSMD1chr2

231948477

+ARMC9chr2

232220510

+
5CDS-3UTRENST00000409643ENST00000483477PSMD1chr2

231951895

+ARMC9chr2

232196505

+
5CDS-3UTRENST00000409643ENST00000483477PSMD1chr2

231951895

+ARMC9chr2

232196504

+
5CDS-3UTRENST00000409643ENST00000483477PSMD1chr2

231951895

+ARMC9chr2

232099937

+
5CDS-3UTRENST00000409643ENST00000483477PSMD1chr2

232003564

+ARMC9chr2

232196505

+
5CDS-3UTRENST00000409643ENST00000483477PSMD1chr2

231948477

+ARMC9chr2

232220510

+
5CDS-intronENST00000308696ENST00000349938PSMD1chr2

231948477

+ARMC9chr2

232220510

+
5CDS-intronENST00000373635ENST00000349938PSMD1chr2

231948477

+ARMC9chr2

232220510

+
5CDS-intronENST00000409643ENST00000349938PSMD1chr2

231948477

+ARMC9chr2

232220510

+
Frame-shiftENST00000308696ENST00000349938PSMD1chr2

231951895

+ARMC9chr2

232196505

+
Frame-shiftENST00000308696ENST00000349938PSMD1chr2

231951895

+ARMC9chr2

232196504

+
Frame-shiftENST00000308696ENST00000349938PSMD1chr2

231951895

+ARMC9chr2

232099937

+
Frame-shiftENST00000373635ENST00000349938PSMD1chr2

231951895

+ARMC9chr2

232196505

+
Frame-shiftENST00000373635ENST00000349938PSMD1chr2

231951895

+ARMC9chr2

232196504

+
Frame-shiftENST00000373635ENST00000349938PSMD1chr2

231951895

+ARMC9chr2

232099937

+
Frame-shiftENST00000409643ENST00000349938PSMD1chr2

231951895

+ARMC9chr2

232196505

+
Frame-shiftENST00000409643ENST00000349938PSMD1chr2

231951895

+ARMC9chr2

232196504

+
Frame-shiftENST00000409643ENST00000349938PSMD1chr2

231951895

+ARMC9chr2

232099937

+
In-frameENST00000308696ENST00000349938PSMD1chr2

232003564

+ARMC9chr2

232196505

+
In-frameENST00000373635ENST00000349938PSMD1chr2

232003564

+ARMC9chr2

232196505

+
In-frameENST00000409643ENST00000349938PSMD1chr2

232003564

+ARMC9chr2

232196505

+
intron-3CDSENST00000488354ENST00000349938PSMD1chr2

232003564

+ARMC9chr2

232196505

+
intron-3UTRENST00000488354ENST00000483477PSMD1chr2

232003564

+ARMC9chr2

232196505

+
intron-3UTRENST00000488354ENST00000483477PSMD1chr2

231948477

+ARMC9chr2

232220510

+
intron-intronENST00000488354ENST00000349938PSMD1chr2

231948477

+ARMC9chr2

232220510

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000373635PSMD1chr2232003564+ENST00000349938ARMC9chr2232196505+24932160992384761
ENST00000308696PSMD1chr2232003564+ENST00000349938ARMC9chr2232196505+24932160992384761
ENST00000409643PSMD1chr2232003564+ENST00000349938ARMC9chr2232196505+24632130692354761

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373635ENST00000349938PSMD1chr2232003564+ARMC9chr2232196505+0.0014341410.99856585
ENST00000308696ENST00000349938PSMD1chr2232003564+ARMC9chr2232196505+0.0014341410.99856585
ENST00000409643ENST00000349938PSMD1chr2232003564+ARMC9chr2232196505+0.0013955980.9986045

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Fusion Genomic Features for PSMD1-ARMC9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PSMD1chr2231948477+ARMC9chr2232220509+2.51E-070.99999976
PSMD1chr2231951895+ARMC9chr2232196504+7.01E-091
PSMD1chr2231951895+ARMC9chr2232099936+2.87E-111
PSMD1chr2232003564+ARMC9chr2232196504+2.97E-111
PSMD1chr2231951895+ARMC9chr2232196504+7.01E-091
PSMD1chr2231948477+ARMC9chr2232220509+2.51E-070.99999976
PSMD1chr2231951895+ARMC9chr2232196504+7.01E-091
PSMD1chr2231951895+ARMC9chr2232099936+2.87E-111
PSMD1chr2232003564+ARMC9chr2232196504+2.97E-111
PSMD1chr2231951895+ARMC9chr2232196504+7.01E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PSMD1-ARMC9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:231951895/chr2:232196505)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePSMD1chr2:232003564chr2:232196505ENST00000308696+1725403_436666992.3333333333334RepeatNote=PC 1
HgenePSMD1chr2:232003564chr2:232196505ENST00000308696+1725441_474666992.3333333333334RepeatNote=PC 2
HgenePSMD1chr2:232003564chr2:232196505ENST00000308696+1725476_510666992.3333333333334RepeatNote=PC 3
HgenePSMD1chr2:232003564chr2:232196505ENST00000308696+1725511_545666992.3333333333334RepeatNote=PC 4
HgenePSMD1chr2:232003564chr2:232196505ENST00000308696+1725547_580666992.3333333333334RepeatNote=PC 5
HgenePSMD1chr2:232003564chr2:232196505ENST00000308696+1725581_616666992.3333333333334RepeatNote=PC 6
HgenePSMD1chr2:232003564chr2:232196505ENST00000308696+1725617_649666992.3333333333334RepeatNote=PC 7
HgenePSMD1chr2:232003564chr2:232196505ENST00000373635+1724403_436666960.3333333333334RepeatNote=PC 1
HgenePSMD1chr2:232003564chr2:232196505ENST00000373635+1724441_474666960.3333333333334RepeatNote=PC 2
HgenePSMD1chr2:232003564chr2:232196505ENST00000373635+1724476_510666960.3333333333334RepeatNote=PC 3
HgenePSMD1chr2:232003564chr2:232196505ENST00000373635+1724511_545666960.3333333333334RepeatNote=PC 4
HgenePSMD1chr2:232003564chr2:232196505ENST00000373635+1724547_580666960.3333333333334RepeatNote=PC 5
HgenePSMD1chr2:232003564chr2:232196505ENST00000373635+1724581_616666960.3333333333334RepeatNote=PC 6
HgenePSMD1chr2:232003564chr2:232196505ENST00000373635+1724617_649666960.3333333333334RepeatNote=PC 7
HgenePSMD1chr2:232003564chr2:232196505ENST00000409643+1723403_436666923.0RepeatNote=PC 1
HgenePSMD1chr2:232003564chr2:232196505ENST00000409643+1723441_474666923.0RepeatNote=PC 2
HgenePSMD1chr2:232003564chr2:232196505ENST00000409643+1723476_510666923.0RepeatNote=PC 3
HgenePSMD1chr2:232003564chr2:232196505ENST00000409643+1723511_545666923.0RepeatNote=PC 4
HgenePSMD1chr2:232003564chr2:232196505ENST00000409643+1723547_580666923.0RepeatNote=PC 5
HgenePSMD1chr2:232003564chr2:232196505ENST00000409643+1723581_616666923.0RepeatNote=PC 6
HgenePSMD1chr2:232003564chr2:232196505ENST00000409643+1723617_649666923.0RepeatNote=PC 7
TgeneARMC9chr2:232003564chr2:232196505ENST000003499381821708_711591666.0Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePSMD1chr2:232003564chr2:232196505ENST00000308696+1725936_943666992.3333333333334Compositional biasNote=Poly-Glu
HgenePSMD1chr2:232003564chr2:232196505ENST00000373635+1724936_943666960.3333333333334Compositional biasNote=Poly-Glu
HgenePSMD1chr2:232003564chr2:232196505ENST00000409643+1723936_943666923.0Compositional biasNote=Poly-Glu
HgenePSMD1chr2:232003564chr2:232196505ENST00000308696+1725651_685666992.3333333333334RepeatNote=PC 8
HgenePSMD1chr2:232003564chr2:232196505ENST00000308696+1725686_726666992.3333333333334RepeatNote=PC 9
HgenePSMD1chr2:232003564chr2:232196505ENST00000308696+1725729_761666992.3333333333334RepeatNote=PC 10
HgenePSMD1chr2:232003564chr2:232196505ENST00000373635+1724651_685666960.3333333333334RepeatNote=PC 8
HgenePSMD1chr2:232003564chr2:232196505ENST00000373635+1724686_726666960.3333333333334RepeatNote=PC 9
HgenePSMD1chr2:232003564chr2:232196505ENST00000373635+1724729_761666960.3333333333334RepeatNote=PC 10
HgenePSMD1chr2:232003564chr2:232196505ENST00000409643+1723651_685666923.0RepeatNote=PC 8
HgenePSMD1chr2:232003564chr2:232196505ENST00000409643+1723686_726666923.0RepeatNote=PC 9
HgenePSMD1chr2:232003564chr2:232196505ENST00000409643+1723729_761666923.0RepeatNote=PC 10
TgeneARMC9chr2:232003564chr2:232196505ENST000003499381821204_230591666.0Coiled coilOntology_term=ECO:0000255
TgeneARMC9chr2:232003564chr2:232196505ENST0000034993818217_39591666.0DomainLisH


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Fusion Gene Sequence for PSMD1-ARMC9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>69669_69669_1_PSMD1-ARMC9_PSMD1_chr2_232003564_ENST00000308696_ARMC9_chr2_232196505_ENST00000349938_length(transcript)=2493nt_BP=2160nt
GGGGTCCTGGCGAGAAGCGAGCCGGCGGCCTGAGGAGGCGACTGACTGAGCAGCGCACCCGGGGAGCAAGGAGGCGCGGTGAACTGAGCG
GCCCCTGAGCTGACAGATACACTGCGCAGCTGGAACGGCGAGCGAGCCGACGGGCGAGTGAGGGGCGCAGCCATGATCACCTCGGCCGCT
GGAATTATTTCTCTTCTGGATGAAGATGAACCACAGCTTAAGGAATTTGCACTACACAAATTGAATGCAGTTGTTAATGACTTCTGGGCA
GAAATTTCCGAGTCCGTAGACAAAATAGAGGTTTTATACGAAGATGAAGGTTTCCGGAGTCGGCAGTTTGCAGCCTTAGTGGCATCTAAA
GTATTTTATCACCTGGGGGCTTTTGAGGAGTCTCTGAATTATGCTCTTGGAGCAGGGGACCTCTTCAATGTCAATGATAACTCTGAATAT
GTGGAAACTATTATAGCAAAATGCATTGATCACTACACCAAACAATGTGTGGAAAATGCAGATTTGCCTGAAGGAGAAAAAAAACCAATT
GACCAGAGATTGGAAGGCATCGTAAATAAAATGTTCCAGCGATGTCTAGATGATCACAAGTATAAACAGGCTATTGGCATTGCTCTGGAG
ACACGAAGACTGGACGTCTTTGAAAAGACCATACTGGAGTCGAATGATGTCCCAGGAATGTTAGCTTATAGCCTTAAGCTCTGCATGTCT
TTAATGCAGAATAAACAGTTTCGGAATAAAGTACTAAGAGTTCTAGTTAAAATCTACATGAACTTGGAGAAACCTGATTTCATCAATGTT
TGTCAGTGCTTAATTTTCTTAGATGATCCTCAGGCTGTGAGTGATATCTTAGAGAAACTGGTAAAGGAAGACAACCTCCTGATGGCATAT
CAGATTTGTTTTGATTTGTATGAAAGTGCTAGCCAGCAGTTTTTGTCATCTGTAATCCAGAATCTTCGAACTGTTGGCACCCCTATTGCT
TCTGTGCCTGGATCCACTAATACGGGTACTGTTCCGGGATCAGAGAAAGACAGTGACTCGATGGAAACAGAAGAAAAGACAAGCAGTGCA
TTTGTAGGAAAGACACCAGAAGCCAGTCCAGAGCCTAAGGACCAGACTTTGAAAATGATTAAAATTTTAAGTGGTGAAATGGCTATTGAG
TTACATCTGCAGTTCTTAATACGAAACAATAATACAGACCTCATGATTCTAAAAAACACAAAGGATGCAGTACGGAATTCTGTATGTCAT
ACTGCAACCGTTATAGCAAACTCTTTTATGCACTGTGGGACAACCAGTGACCAGTTTCTTAGAGATAATTTGGAATGGTTAGCCAGAGCC
ACTAACTGGGCAAAATTTACTGCTACAGCCAGTTTGGGTGTAATTCATAAGGGTCATGAAAAAGAAGCATTACAGTTAATGGCAACATAC
CTTCCCAAGGATACTTCTCCAGGATCAGCCTATCAGGAAGGTGGAGGTCTCTATGCACTAGGTCTTATTCATGCCAATCATGGTGGTGAT
ATAATTGACTATCTGCTTAATCAGCTTAAGAACGCCAGCAATGATATCGTTAGACACGGTGGCAGTCTGGGCCTTGGTTTGGCAGCCATG
GGAACTGCACGTCAAGATGTTTATGATTTGCTAAAAACAAACCTTTATCAGGATGATGCAGTAACAGGGGAAGCAGCTGGCCTGGCCCTA
GGTTTGGTTATGTTGGGCTCTAAAAATGCTCAGGCTATTGAGGACATGGTTGGTTATGCACAAGAAACTCAACATGAGAAGATTCTGCGT
GGTCTTGCAGTTGGCATAGCTTTAGTAATGTATGGGAGGATGGAAGAGGCTGATGCTCTCATTGAATCTCTCTGTCGTGACAAGGACCCA
ATTCTTCGAAGGTCTGGAATGTATACTGTAGCCATGGCTTATTGTGGCTCTGGTAACAACAAAGCAATTCGACGCCTGCTACATGTTGCT
GTAAGTGATGTTAATGATGATGTCAGGAGGGCAGCAGTAGAATCACTTGGGTTCATTCTATTCAGAACCCCTGAACAGTGCCCAAGTGTT
GTCTCTTTGTTGTCAGAGAGTTACAACCCTCATGTGCGCTACGGAGCTGCAATGGCCTTGGGGATATGCTGTGCTGGTACAGGAAACAAG
GAGGACCATGACATCATGGAAGCCGATCTGGACAAAGACGAACTGATCCAGCCCCAGCTCGGAGAACTCTCAGGAGAGAAGCTTCTGACC
ACGGAGTACCTGGGGATCATGACCAACACGGGGAAGACAAGGCGGAAGGGGCTGGCTAATGTGCAGTGGAGCGGGGATGAGCCCCTGCAA
AGGCCCGTCACCCCCGGCGGCCACAGAAACGGGTACCCAGTGTAAGTCAGGGCTAAAGGAAGCGGGAATTGACTTTCTTAAGCTTTGTTT

>69669_69669_1_PSMD1-ARMC9_PSMD1_chr2_232003564_ENST00000308696_ARMC9_chr2_232196505_ENST00000349938_length(amino acids)=761AA_BP=1
MTDTLRSWNGERADGRVRGAAMITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFY
HLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRR
LDVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDNLLMAYQIC
FDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMAIELHL
QFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPK
DTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLV
MLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSD
VNDDVRRAAVESLGFILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGICCAGTGNKEDHDIMEADLDKDELIQPQLGELSGEKLLTTEY

--------------------------------------------------------------
>69669_69669_2_PSMD1-ARMC9_PSMD1_chr2_232003564_ENST00000373635_ARMC9_chr2_232196505_ENST00000349938_length(transcript)=2493nt_BP=2160nt
GGGGTCCTGGCGAGAAGCGAGCCGGCGGCCTGAGGAGGCGACTGACTGAGCAGCGCACCCGGGGAGCAAGGAGGCGCGGTGAACTGAGCG
GCCCCTGAGCTGACAGATACACTGCGCAGCTGGAACGGCGAGCGAGCCGACGGGCGAGTGAGGGGCGCAGCCATGATCACCTCGGCCGCT
GGAATTATTTCTCTTCTGGATGAAGATGAACCACAGCTTAAGGAATTTGCACTACACAAATTGAATGCAGTTGTTAATGACTTCTGGGCA
GAAATTTCCGAGTCCGTAGACAAAATAGAGGTTTTATACGAAGATGAAGGTTTCCGGAGTCGGCAGTTTGCAGCCTTAGTGGCATCTAAA
GTATTTTATCACCTGGGGGCTTTTGAGGAGTCTCTGAATTATGCTCTTGGAGCAGGGGACCTCTTCAATGTCAATGATAACTCTGAATAT
GTGGAAACTATTATAGCAAAATGCATTGATCACTACACCAAACAATGTGTGGAAAATGCAGATTTGCCTGAAGGAGAAAAAAAACCAATT
GACCAGAGATTGGAAGGCATCGTAAATAAAATGTTCCAGCGATGTCTAGATGATCACAAGTATAAACAGGCTATTGGCATTGCTCTGGAG
ACACGAAGACTGGACGTCTTTGAAAAGACCATACTGGAGTCGAATGATGTCCCAGGAATGTTAGCTTATAGCCTTAAGCTCTGCATGTCT
TTAATGCAGAATAAACAGTTTCGGAATAAAGTACTAAGAGTTCTAGTTAAAATCTACATGAACTTGGAGAAACCTGATTTCATCAATGTT
TGTCAGTGCTTAATTTTCTTAGATGATCCTCAGGCTGTGAGTGATATCTTAGAGAAACTGGTAAAGGAAGACAACCTCCTGATGGCATAT
CAGATTTGTTTTGATTTGTATGAAAGTGCTAGCCAGCAGTTTTTGTCATCTGTAATCCAGAATCTTCGAACTGTTGGCACCCCTATTGCT
TCTGTGCCTGGATCCACTAATACGGGTACTGTTCCGGGATCAGAGAAAGACAGTGACTCGATGGAAACAGAAGAAAAGACAAGCAGTGCA
TTTGTAGGAAAGACACCAGAAGCCAGTCCAGAGCCTAAGGACCAGACTTTGAAAATGATTAAAATTTTAAGTGGTGAAATGGCTATTGAG
TTACATCTGCAGTTCTTAATACGAAACAATAATACAGACCTCATGATTCTAAAAAACACAAAGGATGCAGTACGGAATTCTGTATGTCAT
ACTGCAACCGTTATAGCAAACTCTTTTATGCACTGTGGGACAACCAGTGACCAGTTTCTTAGAGATAATTTGGAATGGTTAGCCAGAGCC
ACTAACTGGGCAAAATTTACTGCTACAGCCAGTTTGGGTGTAATTCATAAGGGTCATGAAAAAGAAGCATTACAGTTAATGGCAACATAC
CTTCCCAAGGATACTTCTCCAGGATCAGCCTATCAGGAAGGTGGAGGTCTCTATGCACTAGGTCTTATTCATGCCAATCATGGTGGTGAT
ATAATTGACTATCTGCTTAATCAGCTTAAGAACGCCAGCAATGATATCGTTAGACACGGTGGCAGTCTGGGCCTTGGTTTGGCAGCCATG
GGAACTGCACGTCAAGATGTTTATGATTTGCTAAAAACAAACCTTTATCAGGATGATGCAGTAACAGGGGAAGCAGCTGGCCTGGCCCTA
GGTTTGGTTATGTTGGGCTCTAAAAATGCTCAGGCTATTGAGGACATGGTTGGTTATGCACAAGAAACTCAACATGAGAAGATTCTGCGT
GGTCTTGCAGTTGGCATAGCTTTAGTAATGTATGGGAGGATGGAAGAGGCTGATGCTCTCATTGAATCTCTCTGTCGTGACAAGGACCCA
ATTCTTCGAAGGTCTGGAATGTATACTGTAGCCATGGCTTATTGTGGCTCTGGTAACAACAAAGCAATTCGACGCCTGCTACATGTTGCT
GTAAGTGATGTTAATGATGATGTCAGGAGGGCAGCAGTAGAATCACTTGGGTTCATTCTATTCAGAACCCCTGAACAGTGCCCAAGTGTT
GTCTCTTTGTTGTCAGAGAGTTACAACCCTCATGTGCGCTACGGAGCTGCAATGGCCTTGGGGATATGCTGTGCTGGTACAGGAAACAAG
GAGGACCATGACATCATGGAAGCCGATCTGGACAAAGACGAACTGATCCAGCCCCAGCTCGGAGAACTCTCAGGAGAGAAGCTTCTGACC
ACGGAGTACCTGGGGATCATGACCAACACGGGGAAGACAAGGCGGAAGGGGCTGGCTAATGTGCAGTGGAGCGGGGATGAGCCCCTGCAA
AGGCCCGTCACCCCCGGCGGCCACAGAAACGGGTACCCAGTGTAAGTCAGGGCTAAAGGAAGCGGGAATTGACTTTCTTAAGCTTTGTTT

>69669_69669_2_PSMD1-ARMC9_PSMD1_chr2_232003564_ENST00000373635_ARMC9_chr2_232196505_ENST00000349938_length(amino acids)=761AA_BP=1
MTDTLRSWNGERADGRVRGAAMITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFY
HLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRR
LDVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDNLLMAYQIC
FDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMAIELHL
QFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPK
DTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLV
MLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSD
VNDDVRRAAVESLGFILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGICCAGTGNKEDHDIMEADLDKDELIQPQLGELSGEKLLTTEY

--------------------------------------------------------------
>69669_69669_3_PSMD1-ARMC9_PSMD1_chr2_232003564_ENST00000409643_ARMC9_chr2_232196505_ENST00000349938_length(transcript)=2463nt_BP=2130nt
TGAGGAGGCGACTGACTGAGCAGCGCACCCGGGGAGCAAGGAGGCGCGGTGAACTGAGCGGCCCCTGAGCTGACAGATACACTGCGCAGC
TGGAACGGCGAGCGAGCCGACGGGCGAGTGAGGGGCGCAGCCATGATCACCTCGGCCGCTGGAATTATTTCTCTTCTGGATGAAGATGAA
CCACAGCTTAAGGAATTTGCACTACACAAATTGAATGCAGTTGTTAATGACTTCTGGGCAGAAATTTCCGAGTCCGTAGACAAAATAGAG
GTTTTATACGAAGATGAAGGTTTCCGGAGTCGGCAGTTTGCAGCCTTAGTGGCATCTAAAGTATTTTATCACCTGGGGGCTTTTGAGGAG
TCTCTGAATTATGCTCTTGGAGCAGGGGACCTCTTCAATGTCAATGATAACTCTGAATATGTGGAAACTATTATAGCAAAATGCATTGAT
CACTACACCAAACAATGTGTGGAAAATGCAGATTTGCCTGAAGGAGAAAAAAAACCAATTGACCAGAGATTGGAAGGCATCGTAAATAAA
ATGTTCCAGCGATGTCTAGATGATCACAAGTATAAACAGGCTATTGGCATTGCTCTGGAGACACGAAGACTGGACGTCTTTGAAAAGACC
ATACTGGAGTCGAATGATGTCCCAGGAATGTTAGCTTATAGCCTTAAGCTCTGCATGTCTTTAATGCAGAATAAACAGTTTCGGAATAAA
GTACTAAGAGTTCTAGTTAAAATCTACATGAACTTGGAGAAACCTGATTTCATCAATGTTTGTCAGTGCTTAATTTTCTTAGATGATCCT
CAGGCTGTGAGTGATATCTTAGAGAAACTGGTAAAGGAAGACAACCTCCTGATGGCATATCAGATTTGTTTTGATTTGTATGAAAGTGCT
AGCCAGCAGTTTTTGTCATCTGTAATCCAGAATCTTCGAACTGTTGGCACCCCTATTGCTTCTGTGCCTGGATCCACTAATACGGGTACT
GTTCCGGGATCAGAGAAAGACAGTGACTCGATGGAAACAGAAGAAAAGACAAGCAGTGCATTTGTAGGAAAGACACCAGAAGCCAGTCCA
GAGCCTAAGGACCAGACTTTGAAAATGATTAAAATTTTAAGTGGTGAAATGGCTATTGAGTTACATCTGCAGTTCTTAATACGAAACAAT
AATACAGACCTCATGATTCTAAAAAACACAAAGGATGCAGTACGGAATTCTGTATGTCATACTGCAACCGTTATAGCAAACTCTTTTATG
CACTGTGGGACAACCAGTGACCAGTTTCTTAGAGATAATTTGGAATGGTTAGCCAGAGCCACTAACTGGGCAAAATTTACTGCTACAGCC
AGTTTGGGTGTAATTCATAAGGGTCATGAAAAAGAAGCATTACAGTTAATGGCAACATACCTTCCCAAGGATACTTCTCCAGGATCAGCC
TATCAGGAAGGTGGAGGTCTCTATGCACTAGGTCTTATTCATGCCAATCATGGTGGTGATATAATTGACTATCTGCTTAATCAGCTTAAG
AACGCCAGCAATGATATCGTTAGACACGGTGGCAGTCTGGGCCTTGGTTTGGCAGCCATGGGAACTGCACGTCAAGATGTTTATGATTTG
CTAAAAACAAACCTTTATCAGGATGATGCAGTAACAGGGGAAGCAGCTGGCCTGGCCCTAGGTTTGGTTATGTTGGGCTCTAAAAATGCT
CAGGCTATTGAGGACATGGTTGGTTATGCACAAGAAACTCAACATGAGAAGATTCTGCGTGGTCTTGCAGTTGGCATAGCTTTAGTAATG
TATGGGAGGATGGAAGAGGCTGATGCTCTCATTGAATCTCTCTGTCGTGACAAGGACCCAATTCTTCGAAGGTCTGGAATGTATACTGTA
GCCATGGCTTATTGTGGCTCTGGTAACAACAAAGCAATTCGACGCCTGCTACATGTTGCTGTAAGTGATGTTAATGATGATGTCAGGAGG
GCAGCAGTAGAATCACTTGGGTTCATTCTATTCAGAACCCCTGAACAGTGCCCAAGTGTTGTCTCTTTGTTGTCAGAGAGTTACAACCCT
CATGTGCGCTACGGAGCTGCAATGGCCTTGGGGATATGCTGTGCTGGTACAGGAAACAAGGAGGACCATGACATCATGGAAGCCGATCTG
GACAAAGACGAACTGATCCAGCCCCAGCTCGGAGAACTCTCAGGAGAGAAGCTTCTGACCACGGAGTACCTGGGGATCATGACCAACACG
GGGAAGACAAGGCGGAAGGGGCTGGCTAATGTGCAGTGGAGCGGGGATGAGCCCCTGCAAAGGCCCGTCACCCCCGGCGGCCACAGAAAC
GGGTACCCAGTGTAAGTCAGGGCTAAAGGAAGCGGGAATTGACTTTCTTAAGCTTTGTTTTGATTACAGTGTAAGATGTATGTATTTTTA

>69669_69669_3_PSMD1-ARMC9_PSMD1_chr2_232003564_ENST00000409643_ARMC9_chr2_232196505_ENST00000349938_length(amino acids)=761AA_BP=1
MTDTLRSWNGERADGRVRGAAMITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFY
HLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRR
LDVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDNLLMAYQIC
FDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMAIELHL
QFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPK
DTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLV
MLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSD
VNDDVRRAAVESLGFILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGICCAGTGNKEDHDIMEADLDKDELIQPQLGELSGEKLLTTEY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PSMD1-ARMC9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PSMD1-ARMC9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PSMD1-ARMC9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0431399Familial aplasia of the vermis1GENOMICS_ENGLAND;ORPHANET
TgeneC3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneC4539937JOUBERT SYNDROME 301GENOMICS_ENGLAND;UNIPROT
TgeneC4551568Joubert syndrome 11ORPHANET