Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PCNP-ATR (FusionGDB2 ID:HG57092TG545)

Fusion Gene Summary for PCNP-ATR

check button Fusion gene summary
Fusion gene informationFusion gene name: PCNP-ATR
Fusion gene ID: hg57092tg545
HgeneTgene
Gene symbol

PCNP

ATR

Gene ID

57092

545

Gene namePEST proteolytic signal containing nuclear proteinATR serine/threonine kinase
Synonyms-FCTCS|FRP1|MEC1|SCKL|SCKL1
Cytomap('PCNP')('ATR')

3q12.3

3q23

Type of geneprotein-codingprotein-coding
DescriptionPEST proteolytic signal-containing nuclear proteinPEST-containing nuclear proteinserine/threonine-protein kinase ATRFRAP-related protein-1MEC1, mitosis entry checkpoint 1, homologataxia telangiectasia and Rad3-related protein
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265260, ENST00000296024, 
ENST00000469941, ENST00000486406, 
Fusion gene scores* DoF score14 X 13 X 3=5469 X 8 X 5=360
# samples 1410
** MAII scorelog2(14/546*10)=-1.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCNP [Title/Abstract] AND ATR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPCNP(101298848)-ATR(142185375), # samples:3
Anticipated loss of major functional domain due to fusion event.PCNP-ATR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PCNP-ATR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PCNP-ATR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PCNP-ATR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePCNP

GO:0016567

protein ubiquitination

14741369

HgenePCNP

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

14741369

TgeneATR

GO:0000077

DNA damage checkpoint

14657349

TgeneATR

GO:0006974

cellular response to DNA damage stimulus

27723717|27723720

TgeneATR

GO:0018105

peptidyl-serine phosphorylation

9733515

TgeneATR

GO:0046777

protein autophosphorylation

9733515

TgeneATR

GO:0071480

cellular response to gamma radiation

9925639


check buttonFusion gene breakpoints across PCNP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ATR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A9WK-01APCNPchr3

101298848

-ATRchr3

142185375

-
ChimerDB4PRADTCGA-YL-A9WK-01APCNPchr3

101298848

+ATRchr3

142185375

-
ChimerDB4PRADTCGA-YL-A9WKPCNPchr3

101298848

+ATRchr3

142185375

-


Top

Fusion Gene ORF analysis for PCNP-ATR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265260ENST00000350721PCNPchr3

101298848

+ATRchr3

142185375

-
In-frameENST00000265260ENST00000383101PCNPchr3

101298848

+ATRchr3

142185375

-
In-frameENST00000296024ENST00000350721PCNPchr3

101298848

+ATRchr3

142185375

-
In-frameENST00000296024ENST00000383101PCNPchr3

101298848

+ATRchr3

142185375

-
intron-3CDSENST00000469941ENST00000350721PCNPchr3

101298848

+ATRchr3

142185375

-
intron-3CDSENST00000469941ENST00000383101PCNPchr3

101298848

+ATRchr3

142185375

-
intron-3CDSENST00000486406ENST00000350721PCNPchr3

101298848

+ATRchr3

142185375

-
intron-3CDSENST00000486406ENST00000383101PCNPchr3

101298848

+ATRchr3

142185375

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265260PCNPchr3101298848+ENST00000350721ATRchr3142185375-1840400581647529
ENST00000265260PCNPchr3101298848+ENST00000383101ATRchr3142185375-1839400581647529
ENST00000296024PCNPchr3101298848+ENST00000350721ATRchr3142185375-1739299201546508
ENST00000296024PCNPchr3101298848+ENST00000383101ATRchr3142185375-1738299201546508

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265260ENST00000350721PCNPchr3101298848+ATRchr3142185375-0.0003822130.9996178
ENST00000265260ENST00000383101PCNPchr3101298848+ATRchr3142185375-0.000387740.9996123
ENST00000296024ENST00000350721PCNPchr3101298848+ATRchr3142185375-0.0005928570.9994072
ENST00000296024ENST00000383101PCNPchr3101298848+ATRchr3142185375-0.0006008620.9993992

Top

Fusion Genomic Features for PCNP-ATR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for PCNP-ATR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:101298848/chr3:142185375)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATRchr3:101298848chr3:142185375ENST0000035072138472322_256722292645.0DomainPI3K/PI4K
TgeneATRchr3:101298848chr3:142185375ENST0000035072138472612_264422292645.0DomainFATC
TgeneATRchr3:101298848chr3:142185375ENST0000038310137462322_256721652581.0DomainPI3K/PI4K
TgeneATRchr3:101298848chr3:142185375ENST0000038310137462612_264421652581.0DomainFATC

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATRchr3:101298848chr3:142185375ENST0000035072138471640_218522292645.0DomainFAT
TgeneATRchr3:101298848chr3:142185375ENST0000038310137461640_218521652581.0DomainFAT
TgeneATRchr3:101298848chr3:142185375ENST0000035072138471329_136522292645.0RepeatNote=HEAT 2
TgeneATRchr3:101298848chr3:142185375ENST000003507213847799_83522292645.0RepeatNote=HEAT 1
TgeneATRchr3:101298848chr3:142185375ENST0000038310137461329_136521652581.0RepeatNote=HEAT 2
TgeneATRchr3:101298848chr3:142185375ENST000003831013746799_83521652581.0RepeatNote=HEAT 1


Top

Fusion Gene Sequence for PCNP-ATR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>63406_63406_1_PCNP-ATR_PCNP_chr3_101298848_ENST00000265260_ATR_chr3_142185375_ENST00000350721_length(transcript)=1840nt_BP=400nt
TTTTCATTCCTCGGGACCGCTCTAGGCTGCCACCACGCCGGCTGGCCCCAAAAACTCGATGGTTGTTGGGCGGGGTCGTGACGTCCTTGG
CGTGGCTGCAGGGGAGGCCGCGGCGGGGAAAATGGCGGACGGGAAGGCGGGAGACGAGAAGCCTGAAAAGTCGCAGCGAGCTGGAGCCGC
CGGAGGACCTGAAGAAGAAGCAGAAAAACCTGTGAAAACTAAGACTGTTTCTTCCAGTAATGGAGGGGAAAGTTCCAGTCGCAGCGCTGA
GAAGCGATCAGCTGAAGAAGAAGCTGCCGACCTCCCAACAAAGCCTACAAAGATCTCCAAGTTTGGATTTGCCATAGGTAGTCAGACGAC
AAAGAAAGCATCAGCCATATCCATCAAACTTGGATCAAGTGTTGATGGAAGTAGTTCCACATTAAGCATGAGCACTCATTTTAAAATGCT
TAAAAAGCTGGTAGAAGAAGCAACATTTAGTGAAATCCTCATTCCTCTACAATCAGTCATGATACCTACACTTCCATCAATTCTGGGTAC
CCATGCTAACCATGCTAGCCATGAACCATTTCCTGGACATTGGGCCTATATTGCAGGGTTTGATGATATGGTGGAAATTCTTGCTTCTCT
TCAGAAACCAAAGAAGATTTCTTTAAAAGGCTCAGATGGAAAGTTCTACATCATGATGTGTAAGCCAAAAGATGACCTGAGAAAGGATTG
TAGACTAATGGAATTCAATTCCTTGATTAATAAGTGCTTAAGAAAAGATGCAGAGTCTCGTAGAAGAGAACTTCATATTCGAACATATGC
AGTTATTCCACTAAATGATGAATGTGGGATTATTGAATGGGTGAACAACACTGCTGGTTTGAGACCTATTCTGACCAAACTATATAAAGA
AAAGGGAGTGTATATGACAGGAAAAGAACTTCGCCAGTGTATGCTACCAAAGTCAGCAGCTTTATCTGAAAAACTCAAAGTATTCCGAGA
ATTTCTCCTGCCCAGGCATCCTCCTATTTTTCATGAGTGGTTTCTGAGAACATTCCCTGATCCTACATCATGGTACAGTAGTAGATCAGC
TTACTGCCGTTCCACTGCAGTAATGTCAATGGTTGGTTATATTCTGGGGCTTGGAGACCGTCATGGTGAAAATATTCTCTTTGATTCTTT
GACTGGTGAATGCGTACATGTAGATTTCAATTGTCTTTTCAATAAGGGAGAAACCTTTGAAGTTCCAGAAATTGTGCCATTTCGCCTGAC
TCATAATATGGTTAATGGAATGGGTCCTATGGGAACAGAGGGTCTTTTTCGAAGAGCATGTGAAGTTACAATGAGGCTGATGCGTGATCA
GCGAGAGCCTTTAATGAGTGTCTTAAAGACTTTTCTACATGATCCTCTTGTGGAATGGAGTAAACCAGTGAAAGGGCATTCCAAAGCGCC
ACTGAATGAAACTGGAGAAGTTGTCAATGAAAAGGCCAAGACCCATGTTCTTGACATTGAGCAGCGACTACAAGGTGTAATCAAGACTCG
AAATAGAGTGACAGGACTGCCGTTATCTATTGAAGGACATGTGCATTACCTTATACAGGAAGCTACTGATGAAAACTTACTATGCCAGAT
GTATCTTGGTTGGACTCCATATATGTGAAATGAAATTATGTAAAAGAATATGTTAATAATCTAAAAGTAATGCATTTGGTATGAATCTGT
GGTTGTATCTGTTCAATTCTAAAGTACAACATAAATTTACGTTCTCAGCAACTGTTATTTCTCTCTGATCATTAATTATATGTAAAATAA

>63406_63406_1_PCNP-ATR_PCNP_chr3_101298848_ENST00000265260_ATR_chr3_142185375_ENST00000350721_length(amino acids)=529AA_BP=109
MVVGRGRDVLGVAAGEAAAGKMADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKIS
KFGFAIGSQTTKKASAISIKLGSSVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAG
FDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAG
LRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGD
RHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEW

--------------------------------------------------------------
>63406_63406_2_PCNP-ATR_PCNP_chr3_101298848_ENST00000265260_ATR_chr3_142185375_ENST00000383101_length(transcript)=1839nt_BP=400nt
TTTTCATTCCTCGGGACCGCTCTAGGCTGCCACCACGCCGGCTGGCCCCAAAAACTCGATGGTTGTTGGGCGGGGTCGTGACGTCCTTGG
CGTGGCTGCAGGGGAGGCCGCGGCGGGGAAAATGGCGGACGGGAAGGCGGGAGACGAGAAGCCTGAAAAGTCGCAGCGAGCTGGAGCCGC
CGGAGGACCTGAAGAAGAAGCAGAAAAACCTGTGAAAACTAAGACTGTTTCTTCCAGTAATGGAGGGGAAAGTTCCAGTCGCAGCGCTGA
GAAGCGATCAGCTGAAGAAGAAGCTGCCGACCTCCCAACAAAGCCTACAAAGATCTCCAAGTTTGGATTTGCCATAGGTAGTCAGACGAC
AAAGAAAGCATCAGCCATATCCATCAAACTTGGATCAAGTGTTGATGGAAGTAGTTCCACATTAAGCATGAGCACTCATTTTAAAATGCT
TAAAAAGCTGGTAGAAGAAGCAACATTTAGTGAAATCCTCATTCCTCTACAATCAGTCATGATACCTACACTTCCATCAATTCTGGGTAC
CCATGCTAACCATGCTAGCCATGAACCATTTCCTGGACATTGGGCCTATATTGCAGGGTTTGATGATATGGTGGAAATTCTTGCTTCTCT
TCAGAAACCAAAGAAGATTTCTTTAAAAGGCTCAGATGGAAAGTTCTACATCATGATGTGTAAGCCAAAAGATGACCTGAGAAAGGATTG
TAGACTAATGGAATTCAATTCCTTGATTAATAAGTGCTTAAGAAAAGATGCAGAGTCTCGTAGAAGAGAACTTCATATTCGAACATATGC
AGTTATTCCACTAAATGATGAATGTGGGATTATTGAATGGGTGAACAACACTGCTGGTTTGAGACCTATTCTGACCAAACTATATAAAGA
AAAGGGAGTGTATATGACAGGAAAAGAACTTCGCCAGTGTATGCTACCAAAGTCAGCAGCTTTATCTGAAAAACTCAAAGTATTCCGAGA
ATTTCTCCTGCCCAGGCATCCTCCTATTTTTCATGAGTGGTTTCTGAGAACATTCCCTGATCCTACATCATGGTACAGTAGTAGATCAGC
TTACTGCCGTTCCACTGCAGTAATGTCAATGGTTGGTTATATTCTGGGGCTTGGAGACCGTCATGGTGAAAATATTCTCTTTGATTCTTT
GACTGGTGAATGCGTACATGTAGATTTCAATTGTCTTTTCAATAAGGGAGAAACCTTTGAAGTTCCAGAAATTGTGCCATTTCGCCTGAC
TCATAATATGGTTAATGGAATGGGTCCTATGGGAACAGAGGGTCTTTTTCGAAGAGCATGTGAAGTTACAATGAGGCTGATGCGTGATCA
GCGAGAGCCTTTAATGAGTGTCTTAAAGACTTTTCTACATGATCCTCTTGTGGAATGGAGTAAACCAGTGAAAGGGCATTCCAAAGCGCC
ACTGAATGAAACTGGAGAAGTTGTCAATGAAAAGGCCAAGACCCATGTTCTTGACATTGAGCAGCGACTACAAGGTGTAATCAAGACTCG
AAATAGAGTGACAGGACTGCCGTTATCTATTGAAGGACATGTGCATTACCTTATACAGGAAGCTACTGATGAAAACTTACTATGCCAGAT
GTATCTTGGTTGGACTCCATATATGTGAAATGAAATTATGTAAAAGAATATGTTAATAATCTAAAAGTAATGCATTTGGTATGAATCTGT
GGTTGTATCTGTTCAATTCTAAAGTACAACATAAATTTACGTTCTCAGCAACTGTTATTTCTCTCTGATCATTAATTATATGTAAAATAA

>63406_63406_2_PCNP-ATR_PCNP_chr3_101298848_ENST00000265260_ATR_chr3_142185375_ENST00000383101_length(amino acids)=529AA_BP=109
MVVGRGRDVLGVAAGEAAAGKMADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKIS
KFGFAIGSQTTKKASAISIKLGSSVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAG
FDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAG
LRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGD
RHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEW

--------------------------------------------------------------
>63406_63406_3_PCNP-ATR_PCNP_chr3_101298848_ENST00000296024_ATR_chr3_142185375_ENST00000350721_length(transcript)=1739nt_BP=299nt
GGGAGGCCGCGGCGGGGAAAATGGCGGACGGGAAGGCGGGAGACGAGAAGCCTGAAAAGTCGCAGCGAGCTGGAGCCGCCGGAGGACCTG
AAGAAGAAGCAGAAAAACCTGTGAAAACTAAGACTGTTTCTTCCAGTAATGGAGGGGAAAGTTCCAGTCGCAGCGCTGAGAAGCGATCAG
CTGAAGAAGAAGCTGCCGACCTCCCAACAAAGCCTACAAAGATCTCCAAGTTTGGATTTGCCATAGGTAGTCAGACGACAAAGAAAGCAT
CAGCCATATCCATCAAACTTGGATCAAGTGTTGATGGAAGTAGTTCCACATTAAGCATGAGCACTCATTTTAAAATGCTTAAAAAGCTGG
TAGAAGAAGCAACATTTAGTGAAATCCTCATTCCTCTACAATCAGTCATGATACCTACACTTCCATCAATTCTGGGTACCCATGCTAACC
ATGCTAGCCATGAACCATTTCCTGGACATTGGGCCTATATTGCAGGGTTTGATGATATGGTGGAAATTCTTGCTTCTCTTCAGAAACCAA
AGAAGATTTCTTTAAAAGGCTCAGATGGAAAGTTCTACATCATGATGTGTAAGCCAAAAGATGACCTGAGAAAGGATTGTAGACTAATGG
AATTCAATTCCTTGATTAATAAGTGCTTAAGAAAAGATGCAGAGTCTCGTAGAAGAGAACTTCATATTCGAACATATGCAGTTATTCCAC
TAAATGATGAATGTGGGATTATTGAATGGGTGAACAACACTGCTGGTTTGAGACCTATTCTGACCAAACTATATAAAGAAAAGGGAGTGT
ATATGACAGGAAAAGAACTTCGCCAGTGTATGCTACCAAAGTCAGCAGCTTTATCTGAAAAACTCAAAGTATTCCGAGAATTTCTCCTGC
CCAGGCATCCTCCTATTTTTCATGAGTGGTTTCTGAGAACATTCCCTGATCCTACATCATGGTACAGTAGTAGATCAGCTTACTGCCGTT
CCACTGCAGTAATGTCAATGGTTGGTTATATTCTGGGGCTTGGAGACCGTCATGGTGAAAATATTCTCTTTGATTCTTTGACTGGTGAAT
GCGTACATGTAGATTTCAATTGTCTTTTCAATAAGGGAGAAACCTTTGAAGTTCCAGAAATTGTGCCATTTCGCCTGACTCATAATATGG
TTAATGGAATGGGTCCTATGGGAACAGAGGGTCTTTTTCGAAGAGCATGTGAAGTTACAATGAGGCTGATGCGTGATCAGCGAGAGCCTT
TAATGAGTGTCTTAAAGACTTTTCTACATGATCCTCTTGTGGAATGGAGTAAACCAGTGAAAGGGCATTCCAAAGCGCCACTGAATGAAA
CTGGAGAAGTTGTCAATGAAAAGGCCAAGACCCATGTTCTTGACATTGAGCAGCGACTACAAGGTGTAATCAAGACTCGAAATAGAGTGA
CAGGACTGCCGTTATCTATTGAAGGACATGTGCATTACCTTATACAGGAAGCTACTGATGAAAACTTACTATGCCAGATGTATCTTGGTT
GGACTCCATATATGTGAAATGAAATTATGTAAAAGAATATGTTAATAATCTAAAAGTAATGCATTTGGTATGAATCTGTGGTTGTATCTG
TTCAATTCTAAAGTACAACATAAATTTACGTTCTCAGCAACTGTTATTTCTCTCTGATCATTAATTATATGTAAAATAATATACATTCAG

>63406_63406_3_PCNP-ATR_PCNP_chr3_101298848_ENST00000296024_ATR_chr3_142185375_ENST00000350721_length(amino acids)=508AA_BP=88
MADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKL
GSSVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKG
SDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKEL
RQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFN
CLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNE

--------------------------------------------------------------
>63406_63406_4_PCNP-ATR_PCNP_chr3_101298848_ENST00000296024_ATR_chr3_142185375_ENST00000383101_length(transcript)=1738nt_BP=299nt
GGGAGGCCGCGGCGGGGAAAATGGCGGACGGGAAGGCGGGAGACGAGAAGCCTGAAAAGTCGCAGCGAGCTGGAGCCGCCGGAGGACCTG
AAGAAGAAGCAGAAAAACCTGTGAAAACTAAGACTGTTTCTTCCAGTAATGGAGGGGAAAGTTCCAGTCGCAGCGCTGAGAAGCGATCAG
CTGAAGAAGAAGCTGCCGACCTCCCAACAAAGCCTACAAAGATCTCCAAGTTTGGATTTGCCATAGGTAGTCAGACGACAAAGAAAGCAT
CAGCCATATCCATCAAACTTGGATCAAGTGTTGATGGAAGTAGTTCCACATTAAGCATGAGCACTCATTTTAAAATGCTTAAAAAGCTGG
TAGAAGAAGCAACATTTAGTGAAATCCTCATTCCTCTACAATCAGTCATGATACCTACACTTCCATCAATTCTGGGTACCCATGCTAACC
ATGCTAGCCATGAACCATTTCCTGGACATTGGGCCTATATTGCAGGGTTTGATGATATGGTGGAAATTCTTGCTTCTCTTCAGAAACCAA
AGAAGATTTCTTTAAAAGGCTCAGATGGAAAGTTCTACATCATGATGTGTAAGCCAAAAGATGACCTGAGAAAGGATTGTAGACTAATGG
AATTCAATTCCTTGATTAATAAGTGCTTAAGAAAAGATGCAGAGTCTCGTAGAAGAGAACTTCATATTCGAACATATGCAGTTATTCCAC
TAAATGATGAATGTGGGATTATTGAATGGGTGAACAACACTGCTGGTTTGAGACCTATTCTGACCAAACTATATAAAGAAAAGGGAGTGT
ATATGACAGGAAAAGAACTTCGCCAGTGTATGCTACCAAAGTCAGCAGCTTTATCTGAAAAACTCAAAGTATTCCGAGAATTTCTCCTGC
CCAGGCATCCTCCTATTTTTCATGAGTGGTTTCTGAGAACATTCCCTGATCCTACATCATGGTACAGTAGTAGATCAGCTTACTGCCGTT
CCACTGCAGTAATGTCAATGGTTGGTTATATTCTGGGGCTTGGAGACCGTCATGGTGAAAATATTCTCTTTGATTCTTTGACTGGTGAAT
GCGTACATGTAGATTTCAATTGTCTTTTCAATAAGGGAGAAACCTTTGAAGTTCCAGAAATTGTGCCATTTCGCCTGACTCATAATATGG
TTAATGGAATGGGTCCTATGGGAACAGAGGGTCTTTTTCGAAGAGCATGTGAAGTTACAATGAGGCTGATGCGTGATCAGCGAGAGCCTT
TAATGAGTGTCTTAAAGACTTTTCTACATGATCCTCTTGTGGAATGGAGTAAACCAGTGAAAGGGCATTCCAAAGCGCCACTGAATGAAA
CTGGAGAAGTTGTCAATGAAAAGGCCAAGACCCATGTTCTTGACATTGAGCAGCGACTACAAGGTGTAATCAAGACTCGAAATAGAGTGA
CAGGACTGCCGTTATCTATTGAAGGACATGTGCATTACCTTATACAGGAAGCTACTGATGAAAACTTACTATGCCAGATGTATCTTGGTT
GGACTCCATATATGTGAAATGAAATTATGTAAAAGAATATGTTAATAATCTAAAAGTAATGCATTTGGTATGAATCTGTGGTTGTATCTG
TTCAATTCTAAAGTACAACATAAATTTACGTTCTCAGCAACTGTTATTTCTCTCTGATCATTAATTATATGTAAAATAATATACATTCAG

>63406_63406_4_PCNP-ATR_PCNP_chr3_101298848_ENST00000296024_ATR_chr3_142185375_ENST00000383101_length(amino acids)=508AA_BP=88
MADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKL
GSSVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKG
SDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKEL
RQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFN
CLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PCNP-ATR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PCNP-ATR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PCNP-ATR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC3281203CUTANEOUS TELANGIECTASIA AND CANCER SYNDROME, FAMILIAL2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0004681Bagassosis1CTD_human
TgeneC0032273Pneumoconiosis1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0042076Urologic Neoplasms1CTD_human
TgeneC0265202Seckel syndrome1GENOMICS_ENGLAND;ORPHANET
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC0751571Cancer of Urinary Tract1CTD_human
TgeneC4551474Seckel syndrome 11CTD_human;GENOMICS_ENGLAND