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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADCK1-SLIRP (FusionGDB2 ID:HG57143TG81892)

Fusion Gene Summary for ADCK1-SLIRP

check button Fusion gene summary
Fusion gene informationFusion gene name: ADCK1-SLIRP
Fusion gene ID: hg57143tg81892
HgeneTgene
Gene symbol

ADCK1

SLIRP

Gene ID

57143

81892

Gene nameaarF domain containing kinase 1SRA stem-loop interacting RNA binding protein
Synonyms-C14orf156|DC50|PD04872
Cytomap('ADCK1')('SLIRP')

14q24.3

14q24.3

Type of geneprotein-codingprotein-coding
DescriptionaarF domain-containing protein kinase 1SRA stem-loop-interacting RNA-binding protein, mitochondrial
Modification date2020031320200313
UniProtAcc

Q86TW2

.
Ensembl transtripts involved in fusion geneENST00000238561, ENST00000341211, 
ENST00000556560, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 3=75
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADCK1 [Title/Abstract] AND SLIRP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADCK1(78288861)-SLIRP(78182115), # samples:1
Anticipated loss of major functional domain due to fusion event.ADCK1-SLIRP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCK1-SLIRP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ADCK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SLIRP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EY-A54A-01AADCK1chr14

78288861

+SLIRPchr14

78182115

+


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Fusion Gene ORF analysis for ADCK1-SLIRP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000238561ENST00000238688ADCK1chr14

78288861

+SLIRPchr14

78182115

+
In-frameENST00000238561ENST00000557342ADCK1chr14

78288861

+SLIRPchr14

78182115

+
In-frameENST00000238561ENST00000557431ADCK1chr14

78288861

+SLIRPchr14

78182115

+
In-frameENST00000238561ENST00000557623ADCK1chr14

78288861

+SLIRPchr14

78182115

+
In-frameENST00000341211ENST00000238688ADCK1chr14

78288861

+SLIRPchr14

78182115

+
In-frameENST00000341211ENST00000557342ADCK1chr14

78288861

+SLIRPchr14

78182115

+
In-frameENST00000341211ENST00000557431ADCK1chr14

78288861

+SLIRPchr14

78182115

+
In-frameENST00000341211ENST00000557623ADCK1chr14

78288861

+SLIRPchr14

78182115

+
intron-3CDSENST00000556560ENST00000238688ADCK1chr14

78288861

+SLIRPchr14

78182115

+
intron-3CDSENST00000556560ENST00000557342ADCK1chr14

78288861

+SLIRPchr14

78182115

+
intron-3CDSENST00000556560ENST00000557431ADCK1chr14

78288861

+SLIRPchr14

78182115

+
intron-3CDSENST00000556560ENST00000557623ADCK1chr14

78288861

+SLIRPchr14

78182115

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000238561ADCK1chr1478288861+ENST00000557342SLIRPchr1478182115+5293186491161
ENST00000238561ADCK1chr1478288861+ENST00000238688SLIRPchr1478182115+5233186485159
ENST00000238561ADCK1chr1478288861+ENST00000557623SLIRPchr1478182115+10183186458150
ENST00000238561ADCK1chr1478288861+ENST00000557431SLIRPchr1478182115+8783186536176
ENST00000341211ADCK1chr1478288861+ENST00000557342SLIRPchr1478182115+47326243435130
ENST00000341211ADCK1chr1478288861+ENST00000238688SLIRPchr1478182115+46726243429128
ENST00000341211ADCK1chr1478288861+ENST00000557623SLIRPchr1478182115+96226243402119
ENST00000341211ADCK1chr1478288861+ENST00000557431SLIRPchr1478182115+82226243480145

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000238561ENST00000557342ADCK1chr1478288861+SLIRPchr1478182115+0.0091749010.9908251
ENST00000238561ENST00000238688ADCK1chr1478288861+SLIRPchr1478182115+0.0107447780.9892552
ENST00000238561ENST00000557623ADCK1chr1478288861+SLIRPchr1478182115+0.0141998680.98580015
ENST00000238561ENST00000557431ADCK1chr1478288861+SLIRPchr1478182115+0.0487305450.95126945
ENST00000341211ENST00000557342ADCK1chr1478288861+SLIRPchr1478182115+0.0083923820.99160767
ENST00000341211ENST00000238688ADCK1chr1478288861+SLIRPchr1478182115+0.0097001320.9902998
ENST00000341211ENST00000557623ADCK1chr1478288861+SLIRPchr1478182115+0.0149508990.98504907
ENST00000341211ENST00000557431ADCK1chr1478288861+SLIRPchr1478182115+0.054909630.94509035

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Fusion Genomic Features for ADCK1-SLIRP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ADCK1chr1478288861+SLIRPchr1478182114+1.50E-081
ADCK1chr1478288861+SLIRPchr1478182114+1.50E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ADCK1-SLIRP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:78288861/chr14:78182115)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADCK1

Q86TW2

.
FUNCTION: Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase-independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT (PubMed:31125351). The action of this enzyme is not yet clear (Probable). It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable). {ECO:0000269|PubMed:31125351, ECO:0000305}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCK1chr14:78288861chr14:78182115ENST00000238561+311155_46773524.0DomainProtein kinase
HgeneADCK1chr14:78288861chr14:78182115ENST00000341211+310155_46773456.0DomainProtein kinase
HgeneADCK1chr14:78288861chr14:78182115ENST00000238561+311161_16973524.0Nucleotide bindingATP
HgeneADCK1chr14:78288861chr14:78182115ENST00000341211+310161_16973456.0Nucleotide bindingATP
TgeneSLIRPchr14:78288861chr14:78182115ENST000002386881419_10352108.0DomainRRM
TgeneSLIRPchr14:78288861chr14:78182115ENST000005573421419_10352110.0DomainRRM


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Fusion Gene Sequence for ADCK1-SLIRP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2191_2191_1_ADCK1-SLIRP_ADCK1_chr14_78288861_ENST00000238561_SLIRP_chr14_78182115_ENST00000238688_length(transcript)=523nt_BP=318nt
AGGTGGCTGTCCCCGCACGGTTCCCAGCTAATTCCCCGCTACCGGGTTGCGGCCGGAAGCCGGGCGCCGCGGCTCTGCTTCCCTCGGGGA
TCTGGCGACATGGCCAGAAAGGCTCTCAAGCTTGCTTCGTGGACCAGCATGGCTCTTGCTGCCTCTGGCATCTACTTCTACAGTAACAAG
TACTTGGACCCTAATGACTTTGGCGCTGTCAGGGTGGGCAGAGCAGTTGCTACGACGGCTGTCATCAGTTACGACTACCTCACTTCCCTG
AAGAGTGTCCCTTATGGCTCAGAGGAGTACTTGCAGCTGAGATCTAAGGACAAGGAGACTGGCTTTCACAGAGGTTTGGGTTGGGTTCAG
TTTTCTTCAGAAGAAGGACTTCGGAATGCACTACAACAGGAAAATCATATTATAGATGGAGTAAAGGTTCACACTAGAAGGCCAAAACTT

>2191_2191_1_ADCK1-SLIRP_ADCK1_chr14_78288861_ENST00000238561_SLIRP_chr14_78182115_ENST00000238688_length(amino acids)=159AA_BP=104
MSPHGSQLIPRYRVAAGSRAPRLCFPRGSGDMARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKS

--------------------------------------------------------------
>2191_2191_2_ADCK1-SLIRP_ADCK1_chr14_78288861_ENST00000238561_SLIRP_chr14_78182115_ENST00000557342_length(transcript)=529nt_BP=318nt
AGGTGGCTGTCCCCGCACGGTTCCCAGCTAATTCCCCGCTACCGGGTTGCGGCCGGAAGCCGGGCGCCGCGGCTCTGCTTCCCTCGGGGA
TCTGGCGACATGGCCAGAAAGGCTCTCAAGCTTGCTTCGTGGACCAGCATGGCTCTTGCTGCCTCTGGCATCTACTTCTACAGTAACAAG
TACTTGGACCCTAATGACTTTGGCGCTGTCAGGGTGGGCAGAGCAGTTGCTACGACGGCTGTCATCAGTTACGACTACCTCACTTCCCTG
AAGAGTGTCCCTTATGGCTCAGAGGAGTACTTGCAGCTGAGATCTAAGGACAAGGAGACTGGCTTTCACAGAGGTTTGGGTTGGGTTCAG
TTTTCTTCAGAAGAAGGACTTCGGAATGCACTACAACAGGAAAATCATATTATAGATGGAGTAAAGGTCCAGGTTCACACTAGAAGGCCA

>2191_2191_2_ADCK1-SLIRP_ADCK1_chr14_78288861_ENST00000238561_SLIRP_chr14_78182115_ENST00000557342_length(amino acids)=161AA_BP=104
MSPHGSQLIPRYRVAAGSRAPRLCFPRGSGDMARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKS

--------------------------------------------------------------
>2191_2191_3_ADCK1-SLIRP_ADCK1_chr14_78288861_ENST00000238561_SLIRP_chr14_78182115_ENST00000557431_length(transcript)=878nt_BP=318nt
AGGTGGCTGTCCCCGCACGGTTCCCAGCTAATTCCCCGCTACCGGGTTGCGGCCGGAAGCCGGGCGCCGCGGCTCTGCTTCCCTCGGGGA
TCTGGCGACATGGCCAGAAAGGCTCTCAAGCTTGCTTCGTGGACCAGCATGGCTCTTGCTGCCTCTGGCATCTACTTCTACAGTAACAAG
TACTTGGACCCTAATGACTTTGGCGCTGTCAGGGTGGGCAGAGCAGTTGCTACGACGGCTGTCATCAGTTACGACTACCTCACTTCCCTG
AAGAGTGTCCCTTATGGCTCAGAGGAGTACTTGCAGCTGAGATCTAAGGACAAGGAGACTGGCTTTCACAGAGGTTTGGGTTGGGTTCAG
TTTTCTTCAGAAGAAGGACTTCGGAATGCACTACAACAGGAAAATCATATTATAGATGGAGTAAAGGAATCCTTGTTTCGGGACACCCAG
TGGACAGCGAAAGGAGAGAGACCACCACAGGCAAACGGCCGGAAAGCCGCGCAGTCGCAGCCCGCGCGCTTCACTCCGCCCAAATAAGCC
ACTACCGTCACCAACCCCATCTCGTTCGCCCGAGCCGCGGACCTGAGGGAGCGCTGTCCGCTCCCCGCAAGATGCTCACGCGAAAAACCC
ACTCTTCAGTGTCTGAGACCACTCCGCAGCTTTCGGCCTCGGTGAGCGGGTGAACTAAACCCGGGAAACCGCTGAAAGACCCCAGCTTCG
ACTAGGCCTAGTCGTAGCGGCGGCCAGCGGGAGGGCGTAGCCGTAGTCTTGGCCCACGTCATTCTGTGCCCCGGGTCAGGTCACCGCCCG

>2191_2191_3_ADCK1-SLIRP_ADCK1_chr14_78288861_ENST00000238561_SLIRP_chr14_78182115_ENST00000557431_length(amino acids)=176AA_BP=104
MSPHGSQLIPRYRVAAGSRAPRLCFPRGSGDMARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKS

--------------------------------------------------------------
>2191_2191_4_ADCK1-SLIRP_ADCK1_chr14_78288861_ENST00000238561_SLIRP_chr14_78182115_ENST00000557623_length(transcript)=1018nt_BP=318nt
AGGTGGCTGTCCCCGCACGGTTCCCAGCTAATTCCCCGCTACCGGGTTGCGGCCGGAAGCCGGGCGCCGCGGCTCTGCTTCCCTCGGGGA
TCTGGCGACATGGCCAGAAAGGCTCTCAAGCTTGCTTCGTGGACCAGCATGGCTCTTGCTGCCTCTGGCATCTACTTCTACAGTAACAAG
TACTTGGACCCTAATGACTTTGGCGCTGTCAGGGTGGGCAGAGCAGTTGCTACGACGGCTGTCATCAGTTACGACTACCTCACTTCCCTG
AAGAGTGTCCCTTATGGCTCAGAGGAGTACTTGCAGCTGAGATCTAAGGACAAGGAGACTGGCTTTCACAGAGGTTTGGGTTGGGTTCAG
TTTTCTTCAGAAGAAGGACTTCGGAATGCACTACAACAGGAAAATCATATTATAGATGGAGTAAAGTGTCTCAAATCTCAGCCCACTATA
AGAAGTTAAAATCAGAACTGTTTCATCTTGTCTCAAGTTTCAACATACAACTTCCAATTTTTTTGTCATCATGCTGGCATTTACATCCAA
ATGTAAAGTATGTTAATTTTCGTTTCCCTGAGGATAGGTATTCACATCAACACACACAATATGCTGTTCCTAAACTTGTACCTTGGATTG
GTTGAAGAGCCTTTGGTCATACTGAACTTCATTGGAAGTCCGAGGATTAGGAACACCGAGAGCAATAACTTCACTGATATCCCGATTTTC
ATTTCTCTGAAGTTTCGACCTATTTTGAAATACGACATCACTAACTGAAAACTCTTTATAGACAAGCTGAATATGTTCAATAGAAATACA
ACCAATCTCAGAAACAAAGGATGTGAATATGTCACATTCACATCTTGTGAACATATATTCCTTGATGATACATAATCAAGCTGGCAGCCC
TTATAAAGCATTTCAGATTAGAGGGAGAGTTTTACAATTAGGACGTCCTGTTAGCTCAAAAGAACATCTAACAGATTCGTTGACATGGAA

>2191_2191_4_ADCK1-SLIRP_ADCK1_chr14_78288861_ENST00000238561_SLIRP_chr14_78182115_ENST00000557623_length(amino acids)=150AA_BP=104
MSPHGSQLIPRYRVAAGSRAPRLCFPRGSGDMARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKS

--------------------------------------------------------------
>2191_2191_5_ADCK1-SLIRP_ADCK1_chr14_78288861_ENST00000341211_SLIRP_chr14_78182115_ENST00000238688_length(transcript)=467nt_BP=262nt
AAGCCGGGCGCCGCGGCTCTGCTTCCCTCGGGGATCTGGCGACATGGCCAGAAAGGCTCTCAAGCTTGCTTCGTGGACCAGCATGGCTCT
TGCTGCCTCTGGCATCTACTTCTACAGTAACAAGTACTTGGACCCTAATGACTTTGGCGCTGTCAGGGTGGGCAGAGCAGTTGCTACGAC
GGCTGTCATCAGTTACGACTACCTCACTTCCCTGAAGAGTGTCCCTTATGGCTCAGAGGAGTACTTGCAGCTGAGATCTAAGGACAAGGA
GACTGGCTTTCACAGAGGTTTGGGTTGGGTTCAGTTTTCTTCAGAAGAAGGACTTCGGAATGCACTACAACAGGAAAATCATATTATAGA
TGGAGTAAAGGTTCACACTAGAAGGCCAAAACTTCCGCAAACATCTGATGATGAAAAGAAAGATTTTTGAGACTGCAGCCTATTAATAAA

>2191_2191_5_ADCK1-SLIRP_ADCK1_chr14_78288861_ENST00000341211_SLIRP_chr14_78182115_ENST00000238688_length(amino acids)=128AA_BP=73
MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSVPYGSEEYLQLRSKDKETGFHRGLGWVQFSS

--------------------------------------------------------------
>2191_2191_6_ADCK1-SLIRP_ADCK1_chr14_78288861_ENST00000341211_SLIRP_chr14_78182115_ENST00000557342_length(transcript)=473nt_BP=262nt
AAGCCGGGCGCCGCGGCTCTGCTTCCCTCGGGGATCTGGCGACATGGCCAGAAAGGCTCTCAAGCTTGCTTCGTGGACCAGCATGGCTCT
TGCTGCCTCTGGCATCTACTTCTACAGTAACAAGTACTTGGACCCTAATGACTTTGGCGCTGTCAGGGTGGGCAGAGCAGTTGCTACGAC
GGCTGTCATCAGTTACGACTACCTCACTTCCCTGAAGAGTGTCCCTTATGGCTCAGAGGAGTACTTGCAGCTGAGATCTAAGGACAAGGA
GACTGGCTTTCACAGAGGTTTGGGTTGGGTTCAGTTTTCTTCAGAAGAAGGACTTCGGAATGCACTACAACAGGAAAATCATATTATAGA
TGGAGTAAAGGTCCAGGTTCACACTAGAAGGCCAAAACTTCCGCAAACATCTGATGATGAAAAGAAAGATTTTTGAGACTGCAGCCTATT

>2191_2191_6_ADCK1-SLIRP_ADCK1_chr14_78288861_ENST00000341211_SLIRP_chr14_78182115_ENST00000557342_length(amino acids)=130AA_BP=73
MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSVPYGSEEYLQLRSKDKETGFHRGLGWVQFSS

--------------------------------------------------------------
>2191_2191_7_ADCK1-SLIRP_ADCK1_chr14_78288861_ENST00000341211_SLIRP_chr14_78182115_ENST00000557431_length(transcript)=822nt_BP=262nt
AAGCCGGGCGCCGCGGCTCTGCTTCCCTCGGGGATCTGGCGACATGGCCAGAAAGGCTCTCAAGCTTGCTTCGTGGACCAGCATGGCTCT
TGCTGCCTCTGGCATCTACTTCTACAGTAACAAGTACTTGGACCCTAATGACTTTGGCGCTGTCAGGGTGGGCAGAGCAGTTGCTACGAC
GGCTGTCATCAGTTACGACTACCTCACTTCCCTGAAGAGTGTCCCTTATGGCTCAGAGGAGTACTTGCAGCTGAGATCTAAGGACAAGGA
GACTGGCTTTCACAGAGGTTTGGGTTGGGTTCAGTTTTCTTCAGAAGAAGGACTTCGGAATGCACTACAACAGGAAAATCATATTATAGA
TGGAGTAAAGGAATCCTTGTTTCGGGACACCCAGTGGACAGCGAAAGGAGAGAGACCACCACAGGCAAACGGCCGGAAAGCCGCGCAGTC
GCAGCCCGCGCGCTTCACTCCGCCCAAATAAGCCACTACCGTCACCAACCCCATCTCGTTCGCCCGAGCCGCGGACCTGAGGGAGCGCTG
TCCGCTCCCCGCAAGATGCTCACGCGAAAAACCCACTCTTCAGTGTCTGAGACCACTCCGCAGCTTTCGGCCTCGGTGAGCGGGTGAACT
AAACCCGGGAAACCGCTGAAAGACCCCAGCTTCGACTAGGCCTAGTCGTAGCGGCGGCCAGCGGGAGGGCGTAGCCGTAGTCTTGGCCCA
CGTCATTCTGTGCCCCGGGTCAGGTCACCGCCCGGAGGGTATGGGAAGAGAAATGAAGAAGACTGGTACTCCCAGACCCTTCCGTATCGA

>2191_2191_7_ADCK1-SLIRP_ADCK1_chr14_78288861_ENST00000341211_SLIRP_chr14_78182115_ENST00000557431_length(amino acids)=145AA_BP=73
MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSVPYGSEEYLQLRSKDKETGFHRGLGWVQFSS

--------------------------------------------------------------
>2191_2191_8_ADCK1-SLIRP_ADCK1_chr14_78288861_ENST00000341211_SLIRP_chr14_78182115_ENST00000557623_length(transcript)=962nt_BP=262nt
AAGCCGGGCGCCGCGGCTCTGCTTCCCTCGGGGATCTGGCGACATGGCCAGAAAGGCTCTCAAGCTTGCTTCGTGGACCAGCATGGCTCT
TGCTGCCTCTGGCATCTACTTCTACAGTAACAAGTACTTGGACCCTAATGACTTTGGCGCTGTCAGGGTGGGCAGAGCAGTTGCTACGAC
GGCTGTCATCAGTTACGACTACCTCACTTCCCTGAAGAGTGTCCCTTATGGCTCAGAGGAGTACTTGCAGCTGAGATCTAAGGACAAGGA
GACTGGCTTTCACAGAGGTTTGGGTTGGGTTCAGTTTTCTTCAGAAGAAGGACTTCGGAATGCACTACAACAGGAAAATCATATTATAGA
TGGAGTAAAGTGTCTCAAATCTCAGCCCACTATAAGAAGTTAAAATCAGAACTGTTTCATCTTGTCTCAAGTTTCAACATACAACTTCCA
ATTTTTTTGTCATCATGCTGGCATTTACATCCAAATGTAAAGTATGTTAATTTTCGTTTCCCTGAGGATAGGTATTCACATCAACACACA
CAATATGCTGTTCCTAAACTTGTACCTTGGATTGGTTGAAGAGCCTTTGGTCATACTGAACTTCATTGGAAGTCCGAGGATTAGGAACAC
CGAGAGCAATAACTTCACTGATATCCCGATTTTCATTTCTCTGAAGTTTCGACCTATTTTGAAATACGACATCACTAACTGAAAACTCTT
TATAGACAAGCTGAATATGTTCAATAGAAATACAACCAATCTCAGAAACAAAGGATGTGAATATGTCACATTCACATCTTGTGAACATAT
ATTCCTTGATGATACATAATCAAGCTGGCAGCCCTTATAAAGCATTTCAGATTAGAGGGAGAGTTTTACAATTAGGACGTCCTGTTAGCT

>2191_2191_8_ADCK1-SLIRP_ADCK1_chr14_78288861_ENST00000341211_SLIRP_chr14_78182115_ENST00000557623_length(amino acids)=119AA_BP=73
MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSVPYGSEEYLQLRSKDKETGFHRGLGWVQFSS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ADCK1-SLIRP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADCK1-SLIRP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADCK1-SLIRP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource