Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:NIPAL3-PPP4R1 (FusionGDB2 ID:HG57185TG9989)

Fusion Gene Summary for NIPAL3-PPP4R1

check button Fusion gene summary
Fusion gene informationFusion gene name: NIPAL3-PPP4R1
Fusion gene ID: hg57185tg9989
HgeneTgene
Gene symbol

NIPAL3

PPP4R1

Gene ID

57185

9989

Gene nameNIPA like domain containing 3protein phosphatase 4 regulatory subunit 1
SynonymsDJ462O23.2|NPAL3MEG1|PP4(Rmeg)|PP4R1
Cytomap('NIPAL3')('PPP4R1')

1p36.11

18p11.22

Type of geneprotein-codingprotein-coding
DescriptionNIPA-like protein 3serine/threonine-protein phosphatase 4 regulatory subunit 1serine/threonine phosphatase 4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000003912, ENST00000339255, 
ENST00000374399, ENST00000358028, 
ENST00000428131, ENST00000488155, 
Fusion gene scores* DoF score4 X 5 X 4=8017 X 14 X 9=2142
# samples 617
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/2142*10)=-3.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NIPAL3 [Title/Abstract] AND PPP4R1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNIPAL3(24790610)-PPP4R1(9547950), # samples:1
Anticipated loss of major functional domain due to fusion event.NIPAL3-PPP4R1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NIPAL3-PPP4R1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NIPAL3-PPP4R1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NIPAL3-PPP4R1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NIPAL3-PPP4R1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NIPAL3-PPP4R1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NIPAL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PPP4R1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-XF-AAMY-01ANIPAL3chr1

24790610

-PPP4R1chr18

9547950

-


Top

Fusion Gene ORF analysis for NIPAL3-PPP4R1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000003912ENST00000580583NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
5CDS-intronENST00000339255ENST00000580583NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
5CDS-intronENST00000374399ENST00000580583NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
Frame-shiftENST00000003912ENST00000400555NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
Frame-shiftENST00000339255ENST00000400555NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
Frame-shiftENST00000374399ENST00000400555NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
In-frameENST00000003912ENST00000400556NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
In-frameENST00000339255ENST00000400556NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
In-frameENST00000374399ENST00000400556NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
intron-3CDSENST00000358028ENST00000400555NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
intron-3CDSENST00000358028ENST00000400556NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
intron-3CDSENST00000428131ENST00000400555NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
intron-3CDSENST00000428131ENST00000400556NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
intron-3CDSENST00000488155ENST00000400555NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
intron-3CDSENST00000488155ENST00000400556NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
intron-intronENST00000358028ENST00000580583NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
intron-intronENST00000428131ENST00000580583NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-
intron-intronENST00000488155ENST00000580583NIPAL3chr1

24790610

-PPP4R1chr18

9547950

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374399NIPAL3chr124790610-ENST00000400556PPP4R1chr189547950-255113893681552394
ENST00000003912NIPAL3chr124790610-ENST00000400556PPP4R1chr189547950-265214905681653361
ENST00000339255NIPAL3chr124790610-ENST00000400556PPP4R1chr189547950-253113693481532394

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374399ENST00000400556NIPAL3chr124790610-PPP4R1chr189547950-0.0047474120.9952526
ENST00000003912ENST00000400556NIPAL3chr124790610-PPP4R1chr189547950-0.0017024540.9982975
ENST00000339255ENST00000400556NIPAL3chr124790610-PPP4R1chr189547950-0.0046161270.9953839

Top

Fusion Genomic Features for NIPAL3-PPP4R1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for NIPAL3-PPP4R1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:24790610/chr18:9547950)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912-121318_21258325.0Compositional biasNote=Poly-Ser
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399-111218_21340407.0Compositional biasNote=Poly-Ser
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912-1213101_121258325.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912-1213135_155258325.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912-1213171_191258325.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912-1213202_222258325.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912-1213240_260258325.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912-121333_53258325.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912-121376_96258325.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399-1112101_121340407.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399-1112135_155340407.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399-1112171_191340407.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399-1112202_222340407.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399-1112240_260340407.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399-1112271_291340407.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399-1112300_320340407.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399-111233_53340407.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399-111276_96340407.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028-1818_210227.0Compositional biasNote=Poly-Ser
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131-1718_210227.0Compositional biasNote=Poly-Ser
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912-1213271_291258325.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912-1213300_320258325.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028-18101_1210227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028-18135_1550227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028-18171_1910227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028-18202_2220227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028-18240_2600227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028-18271_2910227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028-18300_3200227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028-1833_530227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028-1876_960227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131-17101_1210227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131-17135_1550227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131-17171_1910227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131-17202_2220227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131-17240_2600227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131-17271_2910227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131-17300_3200227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131-1733_530227.0TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131-1776_960227.0TransmembraneHelical
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005551820127_164879934.0RepeatNote=HEAT 5
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005551820168_206879934.0RepeatNote=HEAT 6
TgenePPP4R1chr1:24790610chr18:9547950ENST0000040055518201_25879934.0RepeatNote=HEAT 1
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005551820208_246879934.0RepeatNote=HEAT 7
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005551820248_285879934.0RepeatNote=HEAT 8
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555182026_63879934.0RepeatNote=HEAT 2
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005551820287_324879934.0RepeatNote=HEAT 9
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005551820505_542879934.0RepeatNote=HEAT 10
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005551820568_606879934.0RepeatNote=HEAT 11
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555182065_81879934.0RepeatNote=HEAT 3
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005551820698_734879934.0RepeatNote=HEAT 12
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005551820799_837879934.0RepeatNote=HEAT 13
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555182082_119879934.0RepeatNote=HEAT 4
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005551820861_898879934.0RepeatNote=HEAT 14
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005561820127_164896951.0RepeatNote=HEAT 5
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005561820168_206896951.0RepeatNote=HEAT 6
TgenePPP4R1chr1:24790610chr18:9547950ENST0000040055618201_25896951.0RepeatNote=HEAT 1
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005561820208_246896951.0RepeatNote=HEAT 7
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005561820248_285896951.0RepeatNote=HEAT 8
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556182026_63896951.0RepeatNote=HEAT 2
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005561820287_324896951.0RepeatNote=HEAT 9
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005561820505_542896951.0RepeatNote=HEAT 10
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005561820568_606896951.0RepeatNote=HEAT 11
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556182065_81896951.0RepeatNote=HEAT 3
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005561820698_734896951.0RepeatNote=HEAT 12
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005561820799_837896951.0RepeatNote=HEAT 13
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556182082_119896951.0RepeatNote=HEAT 4
TgenePPP4R1chr1:24790610chr18:9547950ENST000004005561820861_898896951.0RepeatNote=HEAT 14


Top

Fusion Gene Sequence for NIPAL3-PPP4R1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59186_59186_1_NIPAL3-PPP4R1_NIPAL3_chr1_24790610_ENST00000003912_PPP4R1_chr18_9547950_ENST00000400556_length(transcript)=2652nt_BP=1490nt
AATTGGGAAGGGATGAAGGAGGCTGTGCCTCCGGGTTGCACGAAGAGTCCGAGTCATTTCTCAGAAGGTTTTGATAGGTGGGCCTTAGAG
GAGACGCCGCCGAGCACCGCAAGAACTGGAAAACACACCCCTCTCTGTCTGCCTGGGAGAGCCACGGAAATTGGCACTTCTCTGAGTGAA
GCTGAGGAGAAGGCTGTAAATCTGCCAAAACAGCCTTGAAGTATTCTTTTGTCATGAGGAAGTGACGGCTGCTGGAGGGAGGTGAACACC
ACAAGGAGAGATGGCATCTGGCCTGGGCCCCGCCTAGCAGCAGCTCCACCTCCTAGGCCAGGCCCTGTGGGATGCGCCACTAGACCACCA
TGGACGGATCCCACAGCGCAGCCCTGAAGCTGCAGCAGCTGCCTCCCACAAGTAGCTCCAGCGCCGTAAGCGAGGCCTCCTTCTCCTACA
AGCTGCCCTGAGGAGTAAGTACCGTTAATAACTCCATTTTACAGTTGAGGAAACAAATGCCCAAAGATATGTCCGAGTCACAGTGTCATG
AAGGACAGAGGCTGGATTCAAGGAAAACCTGATTGGCGCCCTCTTGGCGATCTTCGGGCACCTCGTGGTCAGCATTGCACTTAACCTCCA
GAAGTACTGCCACATCCGCCTGGCAGGCTCCAAGGATCCCCGGGCCTATTTCAAGACCAAGACATGGTGGCTGGGCCTGTTCCTGATGCT
TCTGGGCGAGCTGGGTGTGTTCGCCTCCTACGCCTTCGCGCCGCTGTCACTCATCGTGCCCCTCAGCGCAGTTTCTGTGATAGCTAGTGC
CATCATAGGAATCATATTCATCAAGGAAAAGTGGAAACCGAAAGACTTTCTGAGGCGCTACGTCTTGTCCTTTGTTGGCTGCGGTTTGGC
TGTCGTGGGTACCTACCTGCTGGTGACATTCGCACCCAACAGTCACGAGAAGATGACAGGCGAGAATGTCACCAGGCACCTCGTGAGCTG
GCCTTTCCTTTTGTACATGCTGGTGGAGATCATTCTGTTCTGCTTGCTGCTCTACTTCTACAAGGAGAAGAACGCCAACAACATTGTCGT
GATTCTTCTCTTGGTGGCGTTACTTGGCTCCATGACAGTGGTGACAGTCAAGGCCGTGGCTGGGATGCTTGTCTTGTCCATTCAAGGGAA
CCTGCAGCTTGACTACCCCATCTTCTACGTGATGTTCGTGTGCATGGTGGCAACCGCCGTCTATCAGGCTGCGTTTTTGAGTCAAGCCTC
ACAGATGTACGACTCCTCTTTGATTGCCAGTGTGGGCTACATTCTGTCCACAACCATTGCTATCACAGCAGGTGCAATATTTTACCTGGA
CTTCATCGGGGAGGACGTGCTGCACATCTGCATGTTTGCACTGGGGTGCCTCATTGCATTCTTGGGCGTCTTCTTAATCACGCGTAACAG
GAAGAAGCCCATTCCATTTGAGCCCTATATTTCCATGGATGCCATGCCAGACTATTTCTTGGCCTCTGCCAGCTGCCACCAGGAGGCTGT
GGAGCAGACCATCATGGCTCTTCAGATGGACCGTGACAGCGATGTCAAGTATTTTGCAAGCATCCACCCTGCCAGTACCAAAATCTCCGA
AGATGCCATGAGCACAGCGTCCTCAACCTACTAGAAGGCTTGAATCTCGGTGTCTTTCCTGCTTCCATGAGAGCCGAGGTTCAGTGGGCA
TTCGCCACGCATGTGACCTGGGATAGCTTTCGGGGGAGGAGAGACCTTCCTCTCCTGCGGACTTCATTGCAGGTGCAAGTTGCCTACACC
CAATACCAGGGATTTCAAGAGTCAAGAGAAAGTACAGTAAACACTATTATCTTATCTTGACTTTAAGGGGAAATAATTTCTCAGAGGATT
ATAATTGTCACCGAAGCCTTAAATCCTTCTGTCTTCCTGACTGAATGAAACTTGAATTGGCAGAGCATTTTCCTTATGGAAGGGATGAGA
TTCCCAGAGACCTGCATTGCTTTCTCCTGGTTTTATTTAACAATCGACAAATGAAATTCTTACAGCCTGAAGGCAGACGTGTGCCCAGAT
GTGAAAGAGACCTTCAGTATCAGCCCTAACTCTTCTCTCCCAGGAAGGACTTGCTGGGCTCTGTGGCCAGCTGTCCAGCCCAGCCCTGTG
TGTGAATCGTTTGTGACGTGTGCAAATGGGAAAGGAGGGGTTTTTACATCTCCTAAAGGACCTGATGCCAACACAAGTAGGATTGACTTA
AACTCTTAAGCGCAGCATATTGCTGTACACATTTACAGAATGGTTGCTGAGTGTCTGTGTCTGATTTTTTCATGCTGGTCATGACCTGAA
GGAAATTTATTAGACGTATAATGTATGTCTGGTGTTTTTAACTTGATCATGATCAGCTCTGAGGTGCAACTTCTTCACATACTGTACATA
CCTGTGACCACTCTTGGGAGTGCTGCAGTCTTTAATCATGCTGTTTAAACTGTTGTGGCACAAGTTCTCTTGTCCAAATAAAATTTATTA
ATAAGATCTATAGAGAGAGATATATACACTTTTGATTGTTTTCTAGATGTCTACCAATAAATGCAATTTGTGACCTGTATTAATGATTTA
AAGTGGGGAAACTAGATTAAAATATTTGTCTTTTAACTAGTT

>59186_59186_1_NIPAL3-PPP4R1_NIPAL3_chr1_24790610_ENST00000003912_PPP4R1_chr18_9547950_ENST00000400556_length(amino acids)=361AA_BP=306
MIGALLAIFGHLVVSIALNLQKYCHIRLAGSKDPRAYFKTKTWWLGLFLMLLGELGVFASYAFAPLSLIVPLSAVSVIASAIIGIIFIKE
KWKPKDFLRRYVLSFVGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWPFLLYMLVEIILFCLLLYFYKEKNANNIVVILLLVALLG
SMTVVTVKAVAGMLVLSIQGNLQLDYPIFYVMFVCMVATAVYQAAFLSQASQMYDSSLIASVGYILSTTIAITAGAIFYLDFIGEDVLHI
CMFALGCLIAFLGVFLITRNRKKPIPFEPYISMDAMPDYFLASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASST
Y

--------------------------------------------------------------
>59186_59186_2_NIPAL3-PPP4R1_NIPAL3_chr1_24790610_ENST00000339255_PPP4R1_chr18_9547950_ENST00000400556_length(transcript)=2531nt_BP=1369nt
GATGAAGGAGGCTGTGCCTCCGGGTTGCACGAAGAGTCCGAGTCATTTCTCAGAAGGTTTTGATAGGTGGGCCTTAGAGGAGACGCCGCC
GAGCACCGCAAGAACTGGAAAACACACCCCTCTCTGTCTGCCTGGGAGAGCCACGGAAATTGGCACTTCTCTGAGTGAAGCTGAGGAGAA
GGCTGTAAATCTGCCAAAACAGCCTTGAAGTATTCTTTTGTCATGAGGAAGTGACGGCTGCTGGAGGGAGGTGAACACCACAAGGAGAGA
TGGCATCTGGCCTGGGCCCCGCCTAGCAGCAGCTCCACCTCCTAGGCCAGGCCCTGTGGGATGCGCCACTAGACCACCATGGACGGATCC
CACAGCGCAGCCCTGAAGCTGCAGCAGCTGCCTCCCACAAGTAGCTCCAGCGCCGTAAGCGAGGCCTCCTTCTCCTACAAGGAAAACCTG
ATTGGCGCCCTCTTGGCGATCTTCGGGCACCTCGTGGTCAGCATTGCACTTAACCTCCAGAAGTACTGCCACATCCGCCTGGCAGGCTCC
AAGGATCCCCGGGCCTATTTCAAGACCAAGACATGGTGGCTGGGCCTGTTCCTGATGCTTCTGGGCGAGCTGGGTGTGTTCGCCTCCTAC
GCCTTCGCGCCGCTGTCACTCATCGTGCCCCTCAGCGCAGTTTCTGTGATAGCTAGTGCCATCATAGGAATCATATTCATCAAGGAAAAG
TGGAAACCGAAAGACTTTCTGAGGCGCTACGTCTTGTCCTTTGTTGGCTGCGGTTTGGCTGTCGTGGGTACCTACCTGCTGGTGACATTC
GCACCCAACAGTCACGAGAAGATGACAGGCGAGAATGTCACCAGGCACCTCGTGAGCTGGCCTTTCCTTTTGTACATGCTGGTGGAGATC
ATTCTGTTCTGCTTGCTGCTCTACTTCTACAAGGAGAAGAACGCCAACAACATTGTCGTGATTCTTCTCTTGGTGGCGTTACTTGGCTCC
ATGACAGTGGTGACAGTCAAGGCCGTGGCTGGGATGCTTGTCTTGTCCATTCAAGGGAACCTGCAGCTTGACTACCCCATCTTCTACGTG
ATGTTCGTGTGCATGGTGGCAACCGCCGTCTATCAGGCTGCGTTTTTGAGTCAAGCCTCACAGATGTACGACTCCTCTTTGATTGCCAGT
GTGGGCTACATTCTGTCCACAACCATTGCTATCACAGCAGGTGCAATATTTTACCTGGACTTCATCGGGGAGGACGTGCTGCACATCTGC
ATGTTTGCACTGGGGTGCCTCATTGCATTCTTGGGCGTCTTCTTAATCACGCGTAACAGGAAGAAGCCCATTCCATTTGAGCCCTATATT
TCCATGGATGCCATGCCAGACTATTTCTTGGCCTCTGCCAGCTGCCACCAGGAGGCTGTGGAGCAGACCATCATGGCTCTTCAGATGGAC
CGTGACAGCGATGTCAAGTATTTTGCAAGCATCCACCCTGCCAGTACCAAAATCTCCGAAGATGCCATGAGCACAGCGTCCTCAACCTAC
TAGAAGGCTTGAATCTCGGTGTCTTTCCTGCTTCCATGAGAGCCGAGGTTCAGTGGGCATTCGCCACGCATGTGACCTGGGATAGCTTTC
GGGGGAGGAGAGACCTTCCTCTCCTGCGGACTTCATTGCAGGTGCAAGTTGCCTACACCCAATACCAGGGATTTCAAGAGTCAAGAGAAA
GTACAGTAAACACTATTATCTTATCTTGACTTTAAGGGGAAATAATTTCTCAGAGGATTATAATTGTCACCGAAGCCTTAAATCCTTCTG
TCTTCCTGACTGAATGAAACTTGAATTGGCAGAGCATTTTCCTTATGGAAGGGATGAGATTCCCAGAGACCTGCATTGCTTTCTCCTGGT
TTTATTTAACAATCGACAAATGAAATTCTTACAGCCTGAAGGCAGACGTGTGCCCAGATGTGAAAGAGACCTTCAGTATCAGCCCTAACT
CTTCTCTCCCAGGAAGGACTTGCTGGGCTCTGTGGCCAGCTGTCCAGCCCAGCCCTGTGTGTGAATCGTTTGTGACGTGTGCAAATGGGA
AAGGAGGGGTTTTTACATCTCCTAAAGGACCTGATGCCAACACAAGTAGGATTGACTTAAACTCTTAAGCGCAGCATATTGCTGTACACA
TTTACAGAATGGTTGCTGAGTGTCTGTGTCTGATTTTTTCATGCTGGTCATGACCTGAAGGAAATTTATTAGACGTATAATGTATGTCTG
GTGTTTTTAACTTGATCATGATCAGCTCTGAGGTGCAACTTCTTCACATACTGTACATACCTGTGACCACTCTTGGGAGTGCTGCAGTCT
TTAATCATGCTGTTTAAACTGTTGTGGCACAAGTTCTCTTGTCCAAATAAAATTTATTAATAAGATCTATAGAGAGAGATATATACACTT
TTGATTGTTTTCTAGATGTCTACCAATAAATGCAATTTGTGACCTGTATTAATGATTTAAAGTGGGGAAACTAGATTAAAATATTTGTCT
TTTAACTAGTT

>59186_59186_2_NIPAL3-PPP4R1_NIPAL3_chr1_24790610_ENST00000339255_PPP4R1_chr18_9547950_ENST00000400556_length(amino acids)=394AA_BP=339
MDGSHSAALKLQQLPPTSSSSAVSEASFSYKENLIGALLAIFGHLVVSIALNLQKYCHIRLAGSKDPRAYFKTKTWWLGLFLMLLGELGV
FASYAFAPLSLIVPLSAVSVIASAIIGIIFIKEKWKPKDFLRRYVLSFVGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWPFLLYM
LVEIILFCLLLYFYKEKNANNIVVILLLVALLGSMTVVTVKAVAGMLVLSIQGNLQLDYPIFYVMFVCMVATAVYQAAFLSQASQMYDSS
LIASVGYILSTTIAITAGAIFYLDFIGEDVLHICMFALGCLIAFLGVFLITRNRKKPIPFEPYISMDAMPDYFLASASCHQEAVEQTIMA
LQMDRDSDVKYFASIHPASTKISEDAMSTASSTY

--------------------------------------------------------------
>59186_59186_3_NIPAL3-PPP4R1_NIPAL3_chr1_24790610_ENST00000374399_PPP4R1_chr18_9547950_ENST00000400556_length(transcript)=2551nt_BP=1389nt
GCAGCTCTGAATTGGGAAGGGATGAAGGAGGCTGTGCCTCCGGGTTGCACGAAGAGTCCGAGTCATTTCTCAGAAGGTTTTGATAGGTGG
GCCTTAGAGGAGACGCCGCCGAGCACCGCAAGAACTGGAAAACACACCCCTCTCTGTCTGCCTGGGAGAGCCACGGAAATTGGCACTTCT
CTGAGTGAAGCTGAGGAGAAGGCTGTAAATCTGCCAAAACAGCCTTGAAGTATTCTTTTGTCATGAGGAAGTGACGGCTGCTGGAGGGAG
GTGAACACCACAAGGAGAGATGGCATCTGGCCTGGGCCCCGCCTAGCAGCAGCTCCACCTCCTAGGCCAGGCCCTGTGGGATGCGCCACT
AGACCACCATGGACGGATCCCACAGCGCAGCCCTGAAGCTGCAGCAGCTGCCTCCCACAAGTAGCTCCAGCGCCGTAAGCGAGGCCTCCT
TCTCCTACAAGGAAAACCTGATTGGCGCCCTCTTGGCGATCTTCGGGCACCTCGTGGTCAGCATTGCACTTAACCTCCAGAAGTACTGCC
ACATCCGCCTGGCAGGCTCCAAGGATCCCCGGGCCTATTTCAAGACCAAGACATGGTGGCTGGGCCTGTTCCTGATGCTTCTGGGCGAGC
TGGGTGTGTTCGCCTCCTACGCCTTCGCGCCGCTGTCACTCATCGTGCCCCTCAGCGCAGTTTCTGTGATAGCTAGTGCCATCATAGGAA
TCATATTCATCAAGGAAAAGTGGAAACCGAAAGACTTTCTGAGGCGCTACGTCTTGTCCTTTGTTGGCTGCGGTTTGGCTGTCGTGGGTA
CCTACCTGCTGGTGACATTCGCACCCAACAGTCACGAGAAGATGACAGGCGAGAATGTCACCAGGCACCTCGTGAGCTGGCCTTTCCTTT
TGTACATGCTGGTGGAGATCATTCTGTTCTGCTTGCTGCTCTACTTCTACAAGGAGAAGAACGCCAACAACATTGTCGTGATTCTTCTCT
TGGTGGCGTTACTTGGCTCCATGACAGTGGTGACAGTCAAGGCCGTGGCTGGGATGCTTGTCTTGTCCATTCAAGGGAACCTGCAGCTTG
ACTACCCCATCTTCTACGTGATGTTCGTGTGCATGGTGGCAACCGCCGTCTATCAGGCTGCGTTTTTGAGTCAAGCCTCACAGATGTACG
ACTCCTCTTTGATTGCCAGTGTGGGCTACATTCTGTCCACAACCATTGCTATCACAGCAGGTGCAATATTTTACCTGGACTTCATCGGGG
AGGACGTGCTGCACATCTGCATGTTTGCACTGGGGTGCCTCATTGCATTCTTGGGCGTCTTCTTAATCACGCGTAACAGGAAGAAGCCCA
TTCCATTTGAGCCCTATATTTCCATGGATGCCATGCCAGACTATTTCTTGGCCTCTGCCAGCTGCCACCAGGAGGCTGTGGAGCAGACCA
TCATGGCTCTTCAGATGGACCGTGACAGCGATGTCAAGTATTTTGCAAGCATCCACCCTGCCAGTACCAAAATCTCCGAAGATGCCATGA
GCACAGCGTCCTCAACCTACTAGAAGGCTTGAATCTCGGTGTCTTTCCTGCTTCCATGAGAGCCGAGGTTCAGTGGGCATTCGCCACGCA
TGTGACCTGGGATAGCTTTCGGGGGAGGAGAGACCTTCCTCTCCTGCGGACTTCATTGCAGGTGCAAGTTGCCTACACCCAATACCAGGG
ATTTCAAGAGTCAAGAGAAAGTACAGTAAACACTATTATCTTATCTTGACTTTAAGGGGAAATAATTTCTCAGAGGATTATAATTGTCAC
CGAAGCCTTAAATCCTTCTGTCTTCCTGACTGAATGAAACTTGAATTGGCAGAGCATTTTCCTTATGGAAGGGATGAGATTCCCAGAGAC
CTGCATTGCTTTCTCCTGGTTTTATTTAACAATCGACAAATGAAATTCTTACAGCCTGAAGGCAGACGTGTGCCCAGATGTGAAAGAGAC
CTTCAGTATCAGCCCTAACTCTTCTCTCCCAGGAAGGACTTGCTGGGCTCTGTGGCCAGCTGTCCAGCCCAGCCCTGTGTGTGAATCGTT
TGTGACGTGTGCAAATGGGAAAGGAGGGGTTTTTACATCTCCTAAAGGACCTGATGCCAACACAAGTAGGATTGACTTAAACTCTTAAGC
GCAGCATATTGCTGTACACATTTACAGAATGGTTGCTGAGTGTCTGTGTCTGATTTTTTCATGCTGGTCATGACCTGAAGGAAATTTATT
AGACGTATAATGTATGTCTGGTGTTTTTAACTTGATCATGATCAGCTCTGAGGTGCAACTTCTTCACATACTGTACATACCTGTGACCAC
TCTTGGGAGTGCTGCAGTCTTTAATCATGCTGTTTAAACTGTTGTGGCACAAGTTCTCTTGTCCAAATAAAATTTATTAATAAGATCTAT
AGAGAGAGATATATACACTTTTGATTGTTTTCTAGATGTCTACCAATAAATGCAATTTGTGACCTGTATTAATGATTTAAAGTGGGGAAA
CTAGATTAAAATATTTGTCTTTTAACTAGTT

>59186_59186_3_NIPAL3-PPP4R1_NIPAL3_chr1_24790610_ENST00000374399_PPP4R1_chr18_9547950_ENST00000400556_length(amino acids)=394AA_BP=339
MDGSHSAALKLQQLPPTSSSSAVSEASFSYKENLIGALLAIFGHLVVSIALNLQKYCHIRLAGSKDPRAYFKTKTWWLGLFLMLLGELGV
FASYAFAPLSLIVPLSAVSVIASAIIGIIFIKEKWKPKDFLRRYVLSFVGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWPFLLYM
LVEIILFCLLLYFYKEKNANNIVVILLLVALLGSMTVVTVKAVAGMLVLSIQGNLQLDYPIFYVMFVCMVATAVYQAAFLSQASQMYDSS
LIASVGYILSTTIAITAGAIFYLDFIGEDVLHICMFALGCLIAFLGVFLITRNRKKPIPFEPYISMDAMPDYFLASASCHQEAVEQTIMA
LQMDRDSDVKYFASIHPASTKISEDAMSTASSTY

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NIPAL3-PPP4R1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for NIPAL3-PPP4R1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for NIPAL3-PPP4R1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNIPAL3C0033578Prostatic Neoplasms1CTD_human
HgeneNIPAL3C0376358Malignant neoplasm of prostate1CTD_human