Fusion Gene Studies
in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BACH1-DSCR3 (FusionGDB2 ID:HG571TG10311)

Fusion Gene Summary for BACH1-DSCR3

check button Fusion gene summary
Fusion gene informationFusion gene name: BACH1-DSCR3
Fusion gene ID: hg571tg10311
HgeneTgene
Gene symbol

BACH1

DSCR3

Gene ID

571

10311

Gene nameBTB domain and CNC homolog 1VPS26 endosomal protein sorting factor C
SynonymsBACH-1|BTBD24DCRA|DSCR3|DSCRA
Cytomap('BACH1')('DSCR3')

21q21.3

21q22.13

Type of geneprotein-codingprotein-coding
Descriptiontranscription regulator protein BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 1basic region leucine zipper transcriptional regulator BACH1vacuolar protein sorting-associated protein 26CDSCR3 arrestin fold containingDown syndrome critical region 3Down syndrome critical region gene 3Down syndrome critical region protein 3Down syndrome critical region protein A
Modification date2020031320200313
UniProtAcc

O14867

.
Ensembl transtripts involved in fusion geneENST00000286800, ENST00000399921, 
ENST00000462262, 
ENST00000286800, 
ENST00000399921, ENST00000462262, 
Fusion gene scores* DoF score7 X 4 X 7=1965 X 1 X 4=20
# samples 75
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BACH1 [Title/Abstract] AND DSCR3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBACH1(30702014)-DSCR3(38612940), # samples:3
Anticipated loss of major functional domain due to fusion event.BACH1-DSCR3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BACH1-DSCR3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BACH1-DSCR3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BACH1-DSCR3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBACH1

GO:0000122

negative regulation of transcription by RNA polymerase II

24035498

HgeneBACH1

GO:0061418

regulation of transcription from RNA polymerase II promoter in response to hypoxia

12511571


check buttonFusion gene breakpoints across BACH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DSCR3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CQ-7065-01ABACH1chr21

30702014

-DSCR3chr21

38612940

-
ChimerDB4HNSCTCGA-CQ-7065-01ABACH1chr21

30702014

+DSCR3chr21

38612940

-
ChimerDB4HNSCTCGA-CQ-7065BACH1chr21

30702014

+DSCR3chr21

38612940

-


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Fusion Gene ORF analysis for BACH1-DSCR3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000286800ENST00000288304BACH1chr21

30702014

+DSCR3chr21

38612940

-
5CDS-5UTRENST00000286800ENST00000399000BACH1chr21

30702014

+DSCR3chr21

38612940

-
5CDS-5UTRENST00000286800ENST00000539844BACH1chr21

30702014

+DSCR3chr21

38612940

-
5CDS-5UTRENST00000399921ENST00000288304BACH1chr21

30702014

+DSCR3chr21

38612940

-
5CDS-5UTRENST00000399921ENST00000399000BACH1chr21

30702014

+DSCR3chr21

38612940

-
5CDS-5UTRENST00000399921ENST00000539844BACH1chr21

30702014

+DSCR3chr21

38612940

-
5CDS-intronENST00000286800ENST00000398998BACH1chr21

30702014

+DSCR3chr21

38612940

-
5CDS-intronENST00000286800ENST00000399001BACH1chr21

30702014

+DSCR3chr21

38612940

-
5CDS-intronENST00000286800ENST00000476950BACH1chr21

30702014

+DSCR3chr21

38612940

-
5CDS-intronENST00000399921ENST00000398998BACH1chr21

30702014

+DSCR3chr21

38612940

-
5CDS-intronENST00000399921ENST00000399001BACH1chr21

30702014

+DSCR3chr21

38612940

-
5CDS-intronENST00000399921ENST00000476950BACH1chr21

30702014

+DSCR3chr21

38612940

-
In-frameENST00000286800ENST00000309117BACH1chr21

30702014

+DSCR3chr21

38612940

-
In-frameENST00000399921ENST00000309117BACH1chr21

30702014

+DSCR3chr21

38612940

-
intron-3CDSENST00000462262ENST00000309117BACH1chr21

30702014

+DSCR3chr21

38612940

-
intron-5UTRENST00000462262ENST00000288304BACH1chr21

30702014

+DSCR3chr21

38612940

-
intron-5UTRENST00000462262ENST00000399000BACH1chr21

30702014

+DSCR3chr21

38612940

-
intron-5UTRENST00000462262ENST00000539844BACH1chr21

30702014

+DSCR3chr21

38612940

-
intron-intronENST00000462262ENST00000398998BACH1chr21

30702014

+DSCR3chr21

38612940

-
intron-intronENST00000462262ENST00000399001BACH1chr21

30702014

+DSCR3chr21

38612940

-
intron-intronENST00000462262ENST00000476950BACH1chr21

30702014

+DSCR3chr21

38612940

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000286800BACH1chr2130702014+ENST00000309117DSCR3chr2138612940-488019191312755874
ENST00000399921BACH1chr2130702014+ENST00000309117DSCR3chr2138612940-498020192312855874

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000286800ENST00000309117BACH1chr2130702014+DSCR3chr2138612940-0.0005895340.9994105
ENST00000399921ENST00000309117BACH1chr2130702014+DSCR3chr2138612940-0.0005316470.9994684

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Fusion Genomic Features for BACH1-DSCR3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BACH1-DSCR3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:30702014/chr21:38612940)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BACH1

O14867

.
FUNCTION: Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498). {ECO:0000250|UniProtKB:P97302, ECO:0000269|PubMed:24035498}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBACH1chr21:30702014chr21:38612940ENST00000286800+4534_100592737.0DomainBTB
HgeneBACH1chr21:30702014chr21:38612940ENST00000399921+4534_100592737.0DomainBTB
HgeneBACH1chr21:30702014chr21:38612940ENST00000286800+45562_578592737.0RegionBasic motif
HgeneBACH1chr21:30702014chr21:38612940ENST00000286800+45582_589592737.0RegionLeucine-zipper
HgeneBACH1chr21:30702014chr21:38612940ENST00000399921+45562_578592737.0RegionBasic motif
HgeneBACH1chr21:30702014chr21:38612940ENST00000399921+45582_589592737.0RegionLeucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBACH1chr21:30702014chr21:38612940ENST00000286800+45557_620592737.0DomainbZIP
HgeneBACH1chr21:30702014chr21:38612940ENST00000399921+45557_620592737.0DomainbZIP


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Fusion Gene Sequence for BACH1-DSCR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8822_8822_1_BACH1-DSCR3_BACH1_chr21_30702014_ENST00000286800_DSCR3_chr21_38612940_ENST00000309117_length(transcript)=4880nt_BP=1919nt
GAGTGAGTCACCTGACCGCTGCCCTCGCCGCCCGCCGGGCGCTCTCGCTTCAGTCAGTCGGGCCGCGCCGCGCCTCAGCTCTGGTTGATG
ATAATTAGAAGCATGCTTTCCACTGAACTTCCCGACAACATTTGTTATGCAGAATGTCTCTGAGTGAGAACTCGGTTTTTGCCTATGAAT
CTTCTGTGCATAGCACCAATGTTTTACTCAGCCTTAATGACCAGCGGAAGAAAGATGTGCTGTGCGATGTCACCATCTTTGTGGAGGGAC
AGCGGTTCCGCGCTCACCGGTCCGTGCTGGCGGCATGCAGCAGTTACTTCCACTCAAGAATCGTAGGCCAGGCTGATGGAGAGCTGAACA
TTACTCTTCCAGAAGAGGTGACAGTTAAAGGATTTGAACCTTTAATTCAGTTTGCCTACACTGCTAAACTGATTTTAAGTAAAGAGAATG
TGGATGAAGTGTGCAAATGTGTGGAGTTTTTAAGTGTACATAATATTGAGGAATCCTGCTTTCAGTTTCTGAAATTTAAGTTTTTGGACT
CCACTGCAGACCAGCAAGAATGCCCAAGAAAAAAATGCTTTTCATCACACTGTCAGAAAACAGACCTTAAACTTTCACTTTTGGACCAGA
GGGATCTAGAAACTGATGAAGTGGAGGAATTTCTGGAAAATAAAAATGTTCAGACTCCTCAGTGTAAACTCCGCAGGTATCAAGGAAATG
CAAAAGCCTCACCTCCTCTACAAGACAGTGCCAGTCAGACATATGAGTCCATGTGCTTAGAGAAGGATGCTGCTCTGGCCTTGCCTTCTT
TATGCCCCAAATACAGAAAATTCCAAAAAGCATTTGGAACTGACAGAGTCCGTACTGGGGAATCTAGTGTCAAAGACATTCATGCTTCTG
TTCAGCCAAATGAAAGGTCTGAAAATGAATGCCTGGGAGGAGTCCCGGAGTGTAGAGATTTGCAGGTGATGTTAAAATGTGACGAAAGTA
AATTAGCAATGGAACCTGAAGAAACGAAGAAAGATCCTGCTTCTCAGTGCCCAACTGAAAAATCAGAAGTGACTCCTTTCCCCCACAATT
CTTCCATAGACCCTCATGGACTTTATTCTTTGTCTCTTTTACACACATATGACCAATATGGTGACTTGAATTTTGCTGGTATGCAAAACA
CAACAGTGTTAACAGAAAAGCCTTTGTCAGGTACAGACGTCCAAGAAAAAACATTTGGTGAAAGTCAGGATTTACCTTTGAAATCCGACT
TGGGCACCAGGGAAGATAGTAGTGTTGCATCTAGTGATAGGAGTAGTGTGGAGCGAGAAGTGGCAGAACACCTAGCAAAAGGCTTCTGGA
GTGACATTTGCAGCACGGACACTCCTTGCCAAATGCAGTTATCACCTGCTGTGGCCAAAGATGGCTCAGAACAGATCTCACAGAAACGGT
CTGAGTGTCCGTGGTTAGGTATCAGGATTAGTGAGAGCCCAGAACCAGGTCAAAGGACTTTCACAACATTAAGTTCTGTCAACTGCCCTT
TTATAAGTACTCTGAGTACTGAAGGCTGTTCAAGCAATTTGGAAATTGGAAACGATGATTATGTTTCAGAACCCCAGCAAGAACCTTGCC
CATATGCTTGTGTCATTAGCTTGGGAGACGACTCTGAGACGGACACCGAAGGAGACAGTGAATCCTGTTCAGCCAGAGAACAAGAATGTG
AGGTAAAACTGCCATTCAATGCACAACGGATAATTTCACTGTCTCGAAATGATTTTCAGTCCTTGTTGAAAATGCACAAGCTTACTCCAG
AACAGCTGGATTGTATCCATGATATTCGAAGAAGAAGTAAAAACAGAATTGCTGCACAGCGCTGTCGCAAGAGAAAACTTGACTGTATAC
AGAATCTTGAATCAGAAATTGAGAAGCTGGAAGTGCTCTCTGGCGTGGTGGTCATATCGAGTAAGGATTCAGTCCAACACCAGGGAGTGT
CTTTGACCATGGAAGGAACTGTAAACCTCCAGCTCAGTGCCAAAAGTGTGGGTGTGTTTGAAGCTTTTTATAATTCTGTTAAGCCTATCC
AGATTATCAACAGCACCATAGAAATGGTGAAGCCGGGGAAATTTCCCAGCGGCAAAACAGAAATCCCTTTTGAATTTCCTCTGCACTTGA
AGGGTAACAAAGTTCTGTATGAGACGTATCATGGCGTGTTTGTCAACATTCAGTATACACTGCGCTGTGACATGAAGCGGTCTCTGTTGG
CCAAGGACTTGACAAAGACCTGTGAATTTATCGTTCACTCCGCTCCTCAGAAGGGGAAGTTTACTCCCAGTCCCGTGGACTTCACGATTA
CACCTGAAACCTTACAGAACGTCAAAGAGAGAGCTTTGCTTCCCAAATTTCTCCTTCGAGGACATCTCAACTCAACAAACTGTGTCATCA
CGCAGCCACTAACGGGAGAGCTGGTGGTGGAGAGCTCGGAAGCCGCCATCAGAAGCGTGGAGCTGCAGCTGGTGCGCGTGGAGACGTGCG
GGTGTGCAGAAGGCTATGCCCGCGACGCCACGGAGATTCAGAACATTCAGATCGCCGACGGGGATGTGTGCAGGGGCCTCTCTGTCCCCA
TCTACATGGTCTTCCCTAGGCTGTTCACCTGCCCTACACTGGAGACCACCAACTTCAAAGTGGAATTTGAGGTTAACATCGTGGTGCTGC
TTCACCCTGACCACCTCATCACGGAGAACTTCCCGCTGAAGCTCTGCAGGATATAGCCCGGAGGAGGGAAGCATAGAGAACGGGAGTGGC
CATCTGGAAATCCAGCTGGTTATCCAAATCCTAAGGGGAGCTACAGCCAGCGGCATATACTTGTTTTTGTGATTATTCTGTATCAGAAAT
GAAACAGACCCTCAAATTAACTTTCCTTCCTCATTTCTTGAGGCTTCTGCTTCCAACAGGCACCTCTAATCAGACCTTTTCTTTGAAATT
CAACAAGATTTCTTAATGCTATTTGCCAAGACCATTTCACAGAAAACATTGACTGTGGCTCTTGCCTTATCTGTTCCTTTTTAGGTACAG
TAAAACAATTGTGACAGCAGTTTGAGCTTGCTGGAGAGTGGCATCATGGGGACAAAAGGAAACCTCTGACTTGCTAATGGATGTAGCCAG
GGACTCCCCATAGCAAAGGGTCTGTGGCCAGTTGACATCCAGGATGGCTGCAAGCGCACTTGATGGTCAGGAAGTTTGCAGATACTCGCC
AAGGCAGAGCGCAAAGTGCTAGCCACTGGAAATGCATGACTTCCCTCCACCCCTACTCTATTCTGTAGTTTTTTGGTTTTGTTTCTGAGA
CGGAGTCTCAGTCTGTCACCCAGGCTGGAGTGATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGACTCTCCTGCCTCAGCCT
CCCGAGTAGTTGGGATTACAGGTGACTGCCACCGTGCCCGGCTAATGTTTGTATTTTTAGTAGAGACGGGGCTTCACCATCTTGGCCAGG
CTGGTCTTGAACTCCTGACCTCGTGACCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACACCCAGCCTCTG
TAGTTCTTTTTACAACATTTTTCATTATAACTTTAAATTTTTTAAGCAACTGGAAAAGTGTTCCTTGCTCTCTTGGGGGGATTTGGCTGG
TGCCGAAGTGTTTCTGAAGTCTCAAGAACTGCCATAAAATCTCACGCTGCCATTTCCCTGAACAGATACATACATAGAGAGAGACAGTTT
TCCAAACTGTGTCACGCAGGCTGAGTGCACTGGCAGGATCACAGCTCACGGCAGCCTCAACCTCCCTGGCTCAAGCGATCCCTCCCCTCA
GCCTCCTGAGTAGCTGAGACTACAGGTGAGTGCCACCACACTCAGCTAATTTTCAAATTTTTTGTAGACAGGGTCTCCCTATGTTGCCCA
GGCTGGTCTTGAACTCCTAGACTCAAGTGATCCTCCTGTCTTGGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACTGTGCCCAGCA
GTTTCCCAGAATATATTTAAATGCAAAGTTACATGAGGGGAAAACATGTATGTTTGCTCCTGTTGTTACTGGGTAGGTTCTGAACAGCAG
AAACCCATGTGCAGGGTGGGCTGGTGAAGGCCCCTCTCCGCAAGGTGGTAGCAGGAAAAGGTCCTTGACTTGATGAATTTGGTCTGCCTC
TGAGCCACTGGAGGAAGCTGTTTTGAGCCAGGGTTTTTTGGCCTAAAGCCAGCATTTCCTCAGTCTCCCTTTGTGGTTCGAAGGATATGG
ACTATTGCAATACATTTCTTCCTTCAAATCCTGCCACTGTTTTGTTGGCCCACAACTAATAGGACCTCAAAATAAGCCATGCTGCTTTGC
ACACACACTAGCCTTCTTTTGTACTTTTCATTCTGGATGGGCTTGGCCAAAACAGGCTCAGGCCAAAGACCTCCCAAGCTGTATGTACTT
CCAGTATCCTGAAACAGTGTTTGGTGACATAATGCCAAGGGTAAACAAGCCTGATTTAGGCACTGCTTTATCCAGGGGCTTCACCCATGA
AATTAATAAAACTTATCTGAGTCACTTGAAACTTGGTTCCCAGAAAACACATTTCTGGTTTATAATCTCCTTTTATGCTCACCTGACATT
AATTATCTATCCTTGATGATGTGTTTAAACTGAGTAGCAGAAAACAGAGGCCACACTTTCTGGGAAATTTTAAAGGAAGAAACCATTTTT
AATGAGATGAAAATATTTAACGAATTTAAAAAGCTAATGACAATTTTGAGAAAAGGTTTGGGATGTATATTGCTATGTAATTTAATAAAC

>8822_8822_1_BACH1-DSCR3_BACH1_chr21_30702014_ENST00000286800_DSCR3_chr21_38612940_ENST00000309117_length(amino acids)=874AA_BP=596
MLCRMSLSENSVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEP
LIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLKFKFLDSTADQQECPRKKCFSSHCQKTDLKLSLLDQRDLETDEVEEFLEN
KNVQTPQCKLRRYQGNAKASPPLQDSASQTYESMCLEKDAALALPSLCPKYRKFQKAFGTDRVRTGESSVKDIHASVQPNERSENECLGG
VPECRDLQVMLKCDESKLAMEPEETKKDPASQCPTEKSEVTPFPHNSSIDPHGLYSLSLLHTYDQYGDLNFAGMQNTTVLTEKPLSGTDV
QEKTFGESQDLPLKSDLGTREDSSVASSDRSSVEREVAEHLAKGFWSDICSTDTPCQMQLSPAVAKDGSEQISQKRSECPWLGIRISESP
EPGQRTFTTLSSVNCPFISTLSTEGCSSNLEIGNDDYVSEPQQEPCPYACVISLGDDSETDTEGDSESCSAREQECEVKLPFNAQRIISL
SRNDFQSLLKMHKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLEVLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSA
KSVGVFEAFYNSVKPIQIINSTIEMVKPGKFPSGKTEIPFEFPLHLKGNKVLYETYHGVFVNIQYTLRCDMKRSLLAKDLTKTCEFIVHS
APQKGKFTPSPVDFTITPETLQNVKERALLPKFLLRGHLNSTNCVITQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQ

--------------------------------------------------------------
>8822_8822_2_BACH1-DSCR3_BACH1_chr21_30702014_ENST00000399921_DSCR3_chr21_38612940_ENST00000309117_length(transcript)=4980nt_BP=2019nt
GTCTACTCAGCCCGGTGGCTGTCGCGCGTGGAATCGCGTAAGAAAAGCCGAGTTTGTGGCTGGGGAGAGAAGGCCACCGTGCTGAGCTGG
ATTTAGCGAAGACTGGTTTTGGGGACCGGAGAGCCCAGGACTCCCTTTGTTGGAGTTTTGCCCACGCGTTGTAATTAAGCCTCGCACAAT
ATGGTTGATGATAATTAGAAGCATGCTTTCCACTGAACTTCCCGACAACATTTGTTATGCAGAATGTCTCTGAGTGAGAACTCGGTTTTT
GCCTATGAATCTTCTGTGCATAGCACCAATGTTTTACTCAGCCTTAATGACCAGCGGAAGAAAGATGTGCTGTGCGATGTCACCATCTTT
GTGGAGGGACAGCGGTTCCGCGCTCACCGGTCCGTGCTGGCGGCATGCAGCAGTTACTTCCACTCAAGAATCGTAGGCCAGGCTGATGGA
GAGCTGAACATTACTCTTCCAGAAGAGGTGACAGTTAAAGGATTTGAACCTTTAATTCAGTTTGCCTACACTGCTAAACTGATTTTAAGT
AAAGAGAATGTGGATGAAGTGTGCAAATGTGTGGAGTTTTTAAGTGTACATAATATTGAGGAATCCTGCTTTCAGTTTCTGAAATTTAAG
TTTTTGGACTCCACTGCAGACCAGCAAGAATGCCCAAGAAAAAAATGCTTTTCATCACACTGTCAGAAAACAGACCTTAAACTTTCACTT
TTGGACCAGAGGGATCTAGAAACTGATGAAGTGGAGGAATTTCTGGAAAATAAAAATGTTCAGACTCCTCAGTGTAAACTCCGCAGGTAT
CAAGGAAATGCAAAAGCCTCACCTCCTCTACAAGACAGTGCCAGTCAGACATATGAGTCCATGTGCTTAGAGAAGGATGCTGCTCTGGCC
TTGCCTTCTTTATGCCCCAAATACAGAAAATTCCAAAAAGCATTTGGAACTGACAGAGTCCGTACTGGGGAATCTAGTGTCAAAGACATT
CATGCTTCTGTTCAGCCAAATGAAAGGTCTGAAAATGAATGCCTGGGAGGAGTCCCGGAGTGTAGAGATTTGCAGGTGATGTTAAAATGT
GACGAAAGTAAATTAGCAATGGAACCTGAAGAAACGAAGAAAGATCCTGCTTCTCAGTGCCCAACTGAAAAATCAGAAGTGACTCCTTTC
CCCCACAATTCTTCCATAGACCCTCATGGACTTTATTCTTTGTCTCTTTTACACACATATGACCAATATGGTGACTTGAATTTTGCTGGT
ATGCAAAACACAACAGTGTTAACAGAAAAGCCTTTGTCAGGTACAGACGTCCAAGAAAAAACATTTGGTGAAAGTCAGGATTTACCTTTG
AAATCCGACTTGGGCACCAGGGAAGATAGTAGTGTTGCATCTAGTGATAGGAGTAGTGTGGAGCGAGAAGTGGCAGAACACCTAGCAAAA
GGCTTCTGGAGTGACATTTGCAGCACGGACACTCCTTGCCAAATGCAGTTATCACCTGCTGTGGCCAAAGATGGCTCAGAACAGATCTCA
CAGAAACGGTCTGAGTGTCCGTGGTTAGGTATCAGGATTAGTGAGAGCCCAGAACCAGGTCAAAGGACTTTCACAACATTAAGTTCTGTC
AACTGCCCTTTTATAAGTACTCTGAGTACTGAAGGCTGTTCAAGCAATTTGGAAATTGGAAACGATGATTATGTTTCAGAACCCCAGCAA
GAACCTTGCCCATATGCTTGTGTCATTAGCTTGGGAGACGACTCTGAGACGGACACCGAAGGAGACAGTGAATCCTGTTCAGCCAGAGAA
CAAGAATGTGAGGTAAAACTGCCATTCAATGCACAACGGATAATTTCACTGTCTCGAAATGATTTTCAGTCCTTGTTGAAAATGCACAAG
CTTACTCCAGAACAGCTGGATTGTATCCATGATATTCGAAGAAGAAGTAAAAACAGAATTGCTGCACAGCGCTGTCGCAAGAGAAAACTT
GACTGTATACAGAATCTTGAATCAGAAATTGAGAAGCTGGAAGTGCTCTCTGGCGTGGTGGTCATATCGAGTAAGGATTCAGTCCAACAC
CAGGGAGTGTCTTTGACCATGGAAGGAACTGTAAACCTCCAGCTCAGTGCCAAAAGTGTGGGTGTGTTTGAAGCTTTTTATAATTCTGTT
AAGCCTATCCAGATTATCAACAGCACCATAGAAATGGTGAAGCCGGGGAAATTTCCCAGCGGCAAAACAGAAATCCCTTTTGAATTTCCT
CTGCACTTGAAGGGTAACAAAGTTCTGTATGAGACGTATCATGGCGTGTTTGTCAACATTCAGTATACACTGCGCTGTGACATGAAGCGG
TCTCTGTTGGCCAAGGACTTGACAAAGACCTGTGAATTTATCGTTCACTCCGCTCCTCAGAAGGGGAAGTTTACTCCCAGTCCCGTGGAC
TTCACGATTACACCTGAAACCTTACAGAACGTCAAAGAGAGAGCTTTGCTTCCCAAATTTCTCCTTCGAGGACATCTCAACTCAACAAAC
TGTGTCATCACGCAGCCACTAACGGGAGAGCTGGTGGTGGAGAGCTCGGAAGCCGCCATCAGAAGCGTGGAGCTGCAGCTGGTGCGCGTG
GAGACGTGCGGGTGTGCAGAAGGCTATGCCCGCGACGCCACGGAGATTCAGAACATTCAGATCGCCGACGGGGATGTGTGCAGGGGCCTC
TCTGTCCCCATCTACATGGTCTTCCCTAGGCTGTTCACCTGCCCTACACTGGAGACCACCAACTTCAAAGTGGAATTTGAGGTTAACATC
GTGGTGCTGCTTCACCCTGACCACCTCATCACGGAGAACTTCCCGCTGAAGCTCTGCAGGATATAGCCCGGAGGAGGGAAGCATAGAGAA
CGGGAGTGGCCATCTGGAAATCCAGCTGGTTATCCAAATCCTAAGGGGAGCTACAGCCAGCGGCATATACTTGTTTTTGTGATTATTCTG
TATCAGAAATGAAACAGACCCTCAAATTAACTTTCCTTCCTCATTTCTTGAGGCTTCTGCTTCCAACAGGCACCTCTAATCAGACCTTTT
CTTTGAAATTCAACAAGATTTCTTAATGCTATTTGCCAAGACCATTTCACAGAAAACATTGACTGTGGCTCTTGCCTTATCTGTTCCTTT
TTAGGTACAGTAAAACAATTGTGACAGCAGTTTGAGCTTGCTGGAGAGTGGCATCATGGGGACAAAAGGAAACCTCTGACTTGCTAATGG
ATGTAGCCAGGGACTCCCCATAGCAAAGGGTCTGTGGCCAGTTGACATCCAGGATGGCTGCAAGCGCACTTGATGGTCAGGAAGTTTGCA
GATACTCGCCAAGGCAGAGCGCAAAGTGCTAGCCACTGGAAATGCATGACTTCCCTCCACCCCTACTCTATTCTGTAGTTTTTTGGTTTT
GTTTCTGAGACGGAGTCTCAGTCTGTCACCCAGGCTGGAGTGATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGACTCTCCT
GCCTCAGCCTCCCGAGTAGTTGGGATTACAGGTGACTGCCACCGTGCCCGGCTAATGTTTGTATTTTTAGTAGAGACGGGGCTTCACCAT
CTTGGCCAGGCTGGTCTTGAACTCCTGACCTCGTGACCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACAC
CCAGCCTCTGTAGTTCTTTTTACAACATTTTTCATTATAACTTTAAATTTTTTAAGCAACTGGAAAAGTGTTCCTTGCTCTCTTGGGGGG
ATTTGGCTGGTGCCGAAGTGTTTCTGAAGTCTCAAGAACTGCCATAAAATCTCACGCTGCCATTTCCCTGAACAGATACATACATAGAGA
GAGACAGTTTTCCAAACTGTGTCACGCAGGCTGAGTGCACTGGCAGGATCACAGCTCACGGCAGCCTCAACCTCCCTGGCTCAAGCGATC
CCTCCCCTCAGCCTCCTGAGTAGCTGAGACTACAGGTGAGTGCCACCACACTCAGCTAATTTTCAAATTTTTTGTAGACAGGGTCTCCCT
ATGTTGCCCAGGCTGGTCTTGAACTCCTAGACTCAAGTGATCCTCCTGTCTTGGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACT
GTGCCCAGCAGTTTCCCAGAATATATTTAAATGCAAAGTTACATGAGGGGAAAACATGTATGTTTGCTCCTGTTGTTACTGGGTAGGTTC
TGAACAGCAGAAACCCATGTGCAGGGTGGGCTGGTGAAGGCCCCTCTCCGCAAGGTGGTAGCAGGAAAAGGTCCTTGACTTGATGAATTT
GGTCTGCCTCTGAGCCACTGGAGGAAGCTGTTTTGAGCCAGGGTTTTTTGGCCTAAAGCCAGCATTTCCTCAGTCTCCCTTTGTGGTTCG
AAGGATATGGACTATTGCAATACATTTCTTCCTTCAAATCCTGCCACTGTTTTGTTGGCCCACAACTAATAGGACCTCAAAATAAGCCAT
GCTGCTTTGCACACACACTAGCCTTCTTTTGTACTTTTCATTCTGGATGGGCTTGGCCAAAACAGGCTCAGGCCAAAGACCTCCCAAGCT
GTATGTACTTCCAGTATCCTGAAACAGTGTTTGGTGACATAATGCCAAGGGTAAACAAGCCTGATTTAGGCACTGCTTTATCCAGGGGCT
TCACCCATGAAATTAATAAAACTTATCTGAGTCACTTGAAACTTGGTTCCCAGAAAACACATTTCTGGTTTATAATCTCCTTTTATGCTC
ACCTGACATTAATTATCTATCCTTGATGATGTGTTTAAACTGAGTAGCAGAAAACAGAGGCCACACTTTCTGGGAAATTTTAAAGGAAGA
AACCATTTTTAATGAGATGAAAATATTTAACGAATTTAAAAAGCTAATGACAATTTTGAGAAAAGGTTTGGGATGTATATTGCTATGTAA

>8822_8822_2_BACH1-DSCR3_BACH1_chr21_30702014_ENST00000399921_DSCR3_chr21_38612940_ENST00000309117_length(amino acids)=874AA_BP=596
MLCRMSLSENSVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEP
LIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLKFKFLDSTADQQECPRKKCFSSHCQKTDLKLSLLDQRDLETDEVEEFLEN
KNVQTPQCKLRRYQGNAKASPPLQDSASQTYESMCLEKDAALALPSLCPKYRKFQKAFGTDRVRTGESSVKDIHASVQPNERSENECLGG
VPECRDLQVMLKCDESKLAMEPEETKKDPASQCPTEKSEVTPFPHNSSIDPHGLYSLSLLHTYDQYGDLNFAGMQNTTVLTEKPLSGTDV
QEKTFGESQDLPLKSDLGTREDSSVASSDRSSVEREVAEHLAKGFWSDICSTDTPCQMQLSPAVAKDGSEQISQKRSECPWLGIRISESP
EPGQRTFTTLSSVNCPFISTLSTEGCSSNLEIGNDDYVSEPQQEPCPYACVISLGDDSETDTEGDSESCSAREQECEVKLPFNAQRIISL
SRNDFQSLLKMHKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLEVLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSA
KSVGVFEAFYNSVKPIQIINSTIEMVKPGKFPSGKTEIPFEFPLHLKGNKVLYETYHGVFVNIQYTLRCDMKRSLLAKDLTKTCEFIVHS
APQKGKFTPSPVDFTITPETLQNVKERALLPKFLLRGHLNSTNCVITQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQ

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Fusion Gene PPI Analysis for BACH1-DSCR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BACH1-DSCR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BACH1-DSCR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource