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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CNOT6-CLTC (FusionGDB2 ID:HG57472TG1213)

Fusion Gene Summary for CNOT6-CLTC

check button Fusion gene summary
Fusion gene informationFusion gene name: CNOT6-CLTC
Fusion gene ID: hg57472tg1213
HgeneTgene
Gene symbol

CNOT6

CLTC

Gene ID

57472

1213

Gene nameCCR4-NOT transcription complex subunit 6clathrin heavy chain
SynonymsCCR4|Ccr4aCHC|CHC17|CLH-17|CLTCL2|Hc|MRD56
Cytomap('CNOT6')('CLTC')

5q35.3

17q23.1

Type of geneprotein-codingprotein-coding
DescriptionCCR4-NOT transcription complex subunit 6carbon catabolite repression 4 proteincarbon catabolite repressor protein 4 homologcytoplasmic deadenylaseclathrin heavy chain 1clathrin heavy chain on chromosome 17clathrin, heavy polypeptide (Hc)clathrin, heavy polypeptide-like 2
Modification date2020032920200313
UniProtAcc.

Q00610

Ensembl transtripts involved in fusion geneENST00000261951, ENST00000393356, 
ENST00000502447, 
Fusion gene scores* DoF score6 X 6 X 4=14418 X 18 X 8=2592
# samples 522
** MAII scorelog2(5/144*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2592*10)=-3.55849028935997
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNOT6 [Title/Abstract] AND CLTC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCNOT6(179991743)-CLTC(57746137), # samples:1
Anticipated loss of major functional domain due to fusion event.CNOT6-CLTC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CNOT6-CLTC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CNOT6-CLTC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CNOT6-CLTC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCNOT6

GO:0043928

exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay

20065043

HgeneCNOT6

GO:2000327

positive regulation of nuclear receptor transcription coactivator activity

18180299

TgeneCLTC

GO:1900126

negative regulation of hyaluronan biosynthetic process

24251095


check buttonFusion gene breakpoints across CNOT6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CLTC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer5373NCNOT6chr5

179991743

+CLTCchr17

57746137

+


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Fusion Gene ORF analysis for CNOT6-CLTC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261951ENST00000579456CNOT6chr5

179991743

+CLTCchr17

57746137

+
5CDS-intronENST00000261951ENST00000579815CNOT6chr5

179991743

+CLTCchr17

57746137

+
5CDS-intronENST00000393356ENST00000579456CNOT6chr5

179991743

+CLTCchr17

57746137

+
5CDS-intronENST00000393356ENST00000579815CNOT6chr5

179991743

+CLTCchr17

57746137

+
In-frameENST00000261951ENST00000269122CNOT6chr5

179991743

+CLTCchr17

57746137

+
In-frameENST00000261951ENST00000393043CNOT6chr5

179991743

+CLTCchr17

57746137

+
In-frameENST00000393356ENST00000269122CNOT6chr5

179991743

+CLTCchr17

57746137

+
In-frameENST00000393356ENST00000393043CNOT6chr5

179991743

+CLTCchr17

57746137

+
intron-3CDSENST00000502447ENST00000269122CNOT6chr5

179991743

+CLTCchr17

57746137

+
intron-3CDSENST00000502447ENST00000393043CNOT6chr5

179991743

+CLTCchr17

57746137

+
intron-intronENST00000502447ENST00000579456CNOT6chr5

179991743

+CLTCchr17

57746137

+
intron-intronENST00000502447ENST00000579815CNOT6chr5

179991743

+CLTCchr17

57746137

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261951CNOT6chr5179991743+ENST00000393043CLTCchr1757746137+379890828936991136
ENST00000261951CNOT6chr5179991743+ENST00000269122CLTCchr1757746137+626690828938071172
ENST00000393356CNOT6chr5179991743+ENST00000393043CLTCchr1757746137+387398340337741123
ENST00000393356CNOT6chr5179991743+ENST00000269122CLTCchr1757746137+634198340338821159

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261951ENST00000393043CNOT6chr5179991743+CLTCchr1757746137+0.0013086590.9986914
ENST00000261951ENST00000269122CNOT6chr5179991743+CLTCchr1757746137+0.0003805790.99961936
ENST00000393356ENST00000393043CNOT6chr5179991743+CLTCchr1757746137+0.0011644410.9988356
ENST00000393356ENST00000269122CNOT6chr5179991743+CLTCchr1757746137+0.0003688460.99963117

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Fusion Genomic Features for CNOT6-CLTC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CNOT6chr5179991743+CLTCchr1757746137+0.0308448710.9691552
CNOT6chr5179991743+CLTCchr1757746137+0.0308448710.9691552

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CNOT6-CLTC


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:179991743/chr17:57746137)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CLTC

Q00610

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). {ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNOT6chr5:179991743chr17:57746137ENST00000261951+612121_143186558.0RepeatNote=LRR 4
HgeneCNOT6chr5:179991743chr17:57746137ENST00000261951+61252_73186558.0RepeatNote=LRR 1
HgeneCNOT6chr5:179991743chr17:57746137ENST00000261951+61275_96186558.0RepeatNote=LRR 2
HgeneCNOT6chr5:179991743chr17:57746137ENST00000261951+61298_120186558.0RepeatNote=LRR 3
HgeneCNOT6chr5:179991743chr17:57746137ENST00000393356+814121_143186558.0RepeatNote=LRR 4
HgeneCNOT6chr5:179991743chr17:57746137ENST00000393356+81452_73186558.0RepeatNote=LRR 1
HgeneCNOT6chr5:179991743chr17:57746137ENST00000393356+81475_96186558.0RepeatNote=LRR 2
HgeneCNOT6chr5:179991743chr17:57746137ENST00000393356+81498_120186558.0RepeatNote=LRR 3
TgeneCLTCchr5:179991743chr17:57746137ENST0000026912212321213_15227091676.0RegionInvolved in binding clathrin light chain
TgeneCLTCchr5:179991743chr17:57746137ENST0000026912212321550_16757091676.0RegionTrimerization
TgeneCLTCchr5:179991743chr17:57746137ENST0000039304312311213_15227091640.0RegionInvolved in binding clathrin light chain
TgeneCLTCchr5:179991743chr17:57746137ENST0000039304312311550_16757091640.0RegionTrimerization
TgeneCLTCchr5:179991743chr17:57746137ENST0000026912212321128_12697091676.0RepeatCHCR 5
TgeneCLTCchr5:179991743chr17:57746137ENST0000026912212321274_14207091676.0RepeatCHCR 6
TgeneCLTCchr5:179991743chr17:57746137ENST0000026912212321423_15667091676.0RepeatCHCR 7
TgeneCLTCchr5:179991743chr17:57746137ENST000002691221232833_9727091676.0RepeatCHCR 3
TgeneCLTCchr5:179991743chr17:57746137ENST000002691221232979_11247091676.0RepeatCHCR 4
TgeneCLTCchr5:179991743chr17:57746137ENST0000039304312311128_12697091640.0RepeatCHCR 5
TgeneCLTCchr5:179991743chr17:57746137ENST0000039304312311274_14207091640.0RepeatCHCR 6
TgeneCLTCchr5:179991743chr17:57746137ENST0000039304312311423_15667091640.0RepeatCHCR 7
TgeneCLTCchr5:179991743chr17:57746137ENST000003930431231833_9727091640.0RepeatCHCR 3
TgeneCLTCchr5:179991743chr17:57746137ENST000003930431231979_11247091640.0RepeatCHCR 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNOT6chr5:179991743chr17:57746137ENST00000261951+612153_557186558.0RegionNuclease domain
HgeneCNOT6chr5:179991743chr17:57746137ENST00000393356+814153_557186558.0RegionNuclease domain
TgeneCLTCchr5:179991743chr17:57746137ENST000002691221232108_1497091676.0RegionNote=WD40-like repeat 3
TgeneCLTCchr5:179991743chr17:57746137ENST000002691221232150_1957091676.0RegionNote=WD40-like repeat 4
TgeneCLTCchr5:179991743chr17:57746137ENST000002691221232196_2577091676.0RegionNote=WD40-like repeat 5
TgeneCLTCchr5:179991743chr17:57746137ENST00000269122123224_677091676.0RegionNote=WD40-like repeat 1
TgeneCLTCchr5:179991743chr17:57746137ENST000002691221232258_3017091676.0RegionNote=WD40-like repeat 6
TgeneCLTCchr5:179991743chr17:57746137ENST0000026912212322_4797091676.0RegionNote=Globular terminal domain
TgeneCLTCchr5:179991743chr17:57746137ENST000002691221232302_3307091676.0RegionNote=WD40-like repeat 7
TgeneCLTCchr5:179991743chr17:57746137ENST000002691221232449_4657091676.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
TgeneCLTCchr5:179991743chr17:57746137ENST000002691221232480_5237091676.0RegionNote=Flexible linker
TgeneCLTCchr5:179991743chr17:57746137ENST000002691221232524_16757091676.0RegionNote=Heavy chain arm
TgeneCLTCchr5:179991743chr17:57746137ENST000002691221232524_6347091676.0RegionNote=Distal segment
TgeneCLTCchr5:179991743chr17:57746137ENST000002691221232639_16757091676.0RegionNote=Proximal segment
TgeneCLTCchr5:179991743chr17:57746137ENST00000269122123268_1077091676.0RegionNote=WD40-like repeat 2
TgeneCLTCchr5:179991743chr17:57746137ENST000003930431231108_1497091640.0RegionNote=WD40-like repeat 3
TgeneCLTCchr5:179991743chr17:57746137ENST000003930431231150_1957091640.0RegionNote=WD40-like repeat 4
TgeneCLTCchr5:179991743chr17:57746137ENST000003930431231196_2577091640.0RegionNote=WD40-like repeat 5
TgeneCLTCchr5:179991743chr17:57746137ENST00000393043123124_677091640.0RegionNote=WD40-like repeat 1
TgeneCLTCchr5:179991743chr17:57746137ENST000003930431231258_3017091640.0RegionNote=WD40-like repeat 6
TgeneCLTCchr5:179991743chr17:57746137ENST0000039304312312_4797091640.0RegionNote=Globular terminal domain
TgeneCLTCchr5:179991743chr17:57746137ENST000003930431231302_3307091640.0RegionNote=WD40-like repeat 7
TgeneCLTCchr5:179991743chr17:57746137ENST000003930431231449_4657091640.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
TgeneCLTCchr5:179991743chr17:57746137ENST000003930431231480_5237091640.0RegionNote=Flexible linker
TgeneCLTCchr5:179991743chr17:57746137ENST000003930431231524_16757091640.0RegionNote=Heavy chain arm
TgeneCLTCchr5:179991743chr17:57746137ENST000003930431231524_6347091640.0RegionNote=Distal segment
TgeneCLTCchr5:179991743chr17:57746137ENST000003930431231639_16757091640.0RegionNote=Proximal segment
TgeneCLTCchr5:179991743chr17:57746137ENST00000393043123168_1077091640.0RegionNote=WD40-like repeat 2
TgeneCLTCchr5:179991743chr17:57746137ENST000002691221232537_6837091676.0RepeatCHCR 1
TgeneCLTCchr5:179991743chr17:57746137ENST000002691221232686_8287091676.0RepeatCHCR 2
TgeneCLTCchr5:179991743chr17:57746137ENST000003930431231537_6837091640.0RepeatCHCR 1
TgeneCLTCchr5:179991743chr17:57746137ENST000003930431231686_8287091640.0RepeatCHCR 2


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Fusion Gene Sequence for CNOT6-CLTC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17778_17778_1_CNOT6-CLTC_CNOT6_chr5_179991743_ENST00000261951_CLTC_chr17_57746137_ENST00000269122_length(transcript)=6266nt_BP=908nt
CAATGAAAACGAGGGGGGCGCGGAGGAGGAGGCGGCGGCGTCGGTGGCGGCGGCGACGGCGGCGCGGAGGCGAAGGCAGCGGCGGGCGCA
GCGAGGAGGGCGAGGCCGGGGGCCGAGAGGGCGGGAGGGCGTAGTGGCGGCCCGTCGGGGCGGCTGAGGCGGGCAGCCGAAGCAGTGGCT
CTCGGAGGGGGAACAAAGAGCAGCGACTAAGGCGGCAGAGGAGCGGCGGCGGTGGCGGCGCTGCAGCAGCGGGCGGGACTGGTATGGTGG
TTCCACAGGGCAGACCCCGCTGCACTCACAGGGAGGAGGAGGCGGCAGCGGCGGAGGAAGGCGGCGCACCCCGAGAGGCATGCCCAAAGA
AAAATACGAGCCCCCTGACCCTCGGAGGATGTATACAATTATGTCTTCTGAGGAAGCAGCAAATGGAAAGAAATCCCACTGGGCAGAGCT
TGAAATAAGTGGAAAAGTAAGAAGCTTAAGCGCATCTTTGTGGTCACTAACTCACCTGACAGCTTTGCATTTGAGTGACAATTCCCTGTC
CCGAATTCCTTCAGACATTGCCAAGCTTCACAATCTGGTGTATTTGGACCTGTCATCTAATAAAATTCGTAGCTTACCCGCAGAACTCGG
AAACATGGTATCACTCAGGGAGCTCCATTTAAATAACAACCTGTTACGAGTTCTACCTTTTGAGCTGGGAAAACTGTTTCAGTTGCAGAC
TTTAGGCCTGAAAGGAAATCCCCTTACCCAGGATATATTGAACCTTTATCAGGAACCAGATGGAACAAGACGGCTGCTGAACTATTTGCT
TGATAATTTGTCAGGTACTGCAAAAAGAATTACAACAGAACAACCACCTCCAAGGTCTTGGATTATGTTACAAGAACCAGATAGGACAAG
GCCAACTGGTCTCTTTTATTTTCTGGGATCCATTGTTAACTTTAGCCAGGACCCAGATGTGCACTTTAAATATATTCAGGCAGCTTGCAA
GACTGGGCAAATCAAAGAAGTAGAAAGAATCTGTAGAGAAAGCAACTGCTACGATCCTGAGCGAGTCAAGAATTTTCTTAAGGAAGCAAA
ACTAACAGATCAGCTACCACTTATCATTGTGTGTGATCGATTTGACTTTGTCCATGATTTGGTGCTCTATTTATATAGAAATAATCTTCA
AAAGTATATAGAGATATATGTACAGAAGGTGAATCCAAGTCGACTTCCTGTAGTTATTGGAGGATTACTTGATGTTGACTGTTCTGAAGA
TGTCATAAAAAACTTGATTCTTGTTGTAAGAGGTCAATTCTCTACTGATGAGCTTGTTGCTGAGGTTGAAAAAAGAAACAGATTGAAACT
GCTTCTGCCTTGGCTAGAGGCCAGAATTCATGAGGGCTGTGAGGAGCCTGCTACTCACAATGCCTTAGCCAAAATCTACATAGACAGTAA
TAACAACCCGGAGAGATTTCTTCGTGAAAATCCCTACTATGACAGTCGCGTTGTTGGAAAGTATTGTGAGAAGAGAGATCCACATCTGGC
CTGTGTTGCTTATGAACGTGGCCAATGTGATCTGGAACTTATTAATGTTTGCAATGAGAATTCCCTCTTCAAAAGTCTTTCTCGCTACCT
GGTACGTCGAAAGGATCCAGAATTGTGGGGCAGCGTGCTGCTGGAAAGCAATCCTTACAGGAGACCCCTAATTGACCAGGTTGTACAAAC
AGCTTTGTCTGAGACTCAGGACCCTGAAGAAGTGTCAGTAACTGTAAAGGCTTTCATGACTGCAGACCTTCCTAATGAACTCATTGAACT
GCTGGAGAAAATTGTCCTTGATAACTCTGTATTCAGTGAACACAGGAATCTGCAAAACCTCCTTATCCTCACTGCAATTAAGGCTGACCG
TACACGTGTTATGGAGTATATTAACCGCCTGGATAATTATGATGCCCCAGATATTGCCAATATCGCCATCAGCAATGAGCTGTTTGAAGA
AGCATTTGCCATTTTCCGGAAATTTGATGTCAATACTTCAGCAGTTCAGGTCTTAATTGAGCATATTGGAAACTTGGATCGGGCATATGA
GTTTGCTGAACGTTGCAATGAACCTGCGGTCTGGAGTCAACTTGCAAAAGCCCAGTTGCAGAAAGGAATGGTGAAAGAAGCCATTGATTC
TTATATCAAAGCAGATGATCCTTCCTCCTACATGGAAGTTGTTCAGGCTGCCAATACTAGTGGAAACTGGGAAGAACTGGTGAAGTACTT
GCAGATGGCCCGTAAGAAGGCTCGAGAGTCCTATGTGGAGACAGAACTGATATTCGCACTGGCTAAAACAAACCGCCTTGCAGAGTTAGA
AGAATTTATCAATGGACCAAATAATGCTCATATCCAACAAGTTGGTGACCGTTGTTATGATGAAAAAATGTATGATGCTGCTAAGTTGTT
GTACAATAATGTTTCCAATTTTGGACGTTTGGCATCTACCCTGGTTCACCTGGGTGAATATCAGGCAGCTGTTGATGGGGCTAGGAAAGC
TAACAGTACTCGAACATGGAAAGAGGTCTGCTTCGCCTGTGTAGATGGGAAAGAATTCCGTCTTGCTCAGATGTGTGGACTTCATATTGT
TGTACATGCAGATGAATTAGAAGAACTTATCAACTACTATCAGGATCGTGGCTATTTTGAAGAGCTGATCACCATGTTGGAAGCAGCACT
GGGACTTGAGCGAGCTCACATGGGAATGTTTACTGAATTAGCTATTCTATACTCTAAATTTAAGCCTCAGAAAATGAGGGAGCACCTGGA
GCTGTTCTGGTCTAGAGTGAATATTCCCAAGGTGCTAAGAGCTGCAGAACAAGCTCATCTTTGGGCAGAACTGGTGTTTTTGTATGACAA
GTATGAAGAATATGATAATGCCATAATTACCATGATGAATCATCCAACTGATGCCTGGAAAGAAGGGCAATTCAAAGATATCATTACCAA
GGTTGCCAATGTGGAACTATACTACAGAGCAATACAGTTCTACTTAGAATTCAAGCCTCTGTTGTTAAATGATTTGCTGATGGTGCTGTC
TCCACGGTTGGATCACACTCGTGCAGTCAATTATTTCAGCAAGGTTAAACAGCTACCACTGGTGAAACCGTATTTGCGTTCAGTTCAGAA
CCATAACAACAAATCTGTGAATGAATCATTGAACAATCTTTTTATTACAGAAGAAGATTATCAGGCTCTGCGAACATCAATAGATGCTTA
TGACAACTTTGACAATATCTCGCTTGCTCAGCGTTTGGAAAAACATGAACTCATTGAGTTCAGGAGAATTGCTGCTTATCTCTTCAAAGG
CAACAATCGCTGGAAACAGAGTGTAGAGCTGTGCAAGAAAGACAGCCTTTACAAGGATGCAATGCAGTATGCTTCTGAATCTAAAGATAC
TGAATTGGCTGAAGAACTCCTGCAGTGGTTTTTGCAGGAAGAAAAAAGAGAGTGCTTTGGAGCTTGTCTGTTTACCTGTTACGATCTTTT
AAGGCCAGATGTCGTCCTAGAAACTGCATGGAGGCACAATATCATGGATTTTGCCATGCCCTATTTCATCCAGGTCATGAAGGAGTACTT
GACAAAGGTGGATAAATTAGATGCTTCAGAATCACTGAGAAAAGAAGAAGAACAAGCTACAGAGACACAACCCATTGTTTATGGTCAGCC
CCAGTTGATGCTGACAGCAGGACCCAGTGTTGCCGTCCCTCCCCAGGCACCTTTTGGTTATGGTTATACCGCACCACCGTATGGACAGCC
ACAGCCTGGCTTTGGGTACAGCATGTGAGATGAAGCGCTGATCCTGTAGTCACCTATTTTCGTACTGAAACATCGTCTTTACCCACTTCT
CAGTTTATAATGGGGGAAAACAGGCAACGTGTTCTTGTAACCTTTATTTCATGAAGGACTTCTTTTTGTTTCTAACTATAAACTTGGATC
ACCTATGTTAAAACCTTATTTCACATTCCACATCATTTTAGAATTTATTTTCGAAGGGGAATAGTTTCAATGTTTTATTCACTTGGGCTT
TTTTTCTTCCCCCTCTTTCTTTAAAGAACTGCTCAATATTCAATCTGTTGTGAAGAACCTGATTTGCACTCTGTAGTGTTTAAAGAAACA
AAGAAACTCTAATATTGAATCTCTTAAATTTAGTGTATGTAAACAGCTTACAAATACGTATTGTCTAAATGCATTTAAATCTGTTTTATT
CAAAGAAAAGCTAAAGCAAAAACACTGGCATATGACCATGCAAGACTGTCAGTGCCAACAAAGACAACACTAATCAGCACATCGTACACT
GGATTGCAGTGCTTCCCAGATTATTGAAAAATGTTACAGACAACTTGCCTGATTTTTAAATGAGCGTAAAAGGCCCTCTAACCTATGCAG
GTTTCCCCATTATGCATATAGAAAATGCTAGTATGTTTTGCTCACTTCATATGTAACAGGTGCCCTTATGTTGTGCTGTATCCTGTGCTT
TTTCTGTGGGACCATTCCATTCAGGAGCAAAGAGCACCATGATTCCAATCTTGTGTGTGTTTACTAACCCTTCCCTGAGGTTTGTGTATG
TTGGATATTGTGGTGTTTTAGATCACTGAGTGTACAGAAGAGAGAAATTCAAACAAAATATTGCTGTTCTTCAGTTTTGTTTGTGGAATT
TGAAATTACTCAAATTTAAAATAAATTACTGGACTGTGGAAATAACATAGAATTGAAGTTTTAATTAAATACCACTCAAACGAAAAGAAC
AGTAGTTTTTGTAGTTTTATATTGGATACTGAGGCATTAGGGAGGCATGAAAGGAAGAGGAATGAGGATTGAGACATGTGAAGACATTGT
GCATTATATCAATGTGCATTCCTGTAGTTCATTAACAAGGTACATGCAATAGTCTAAAGAACCAGAGTCACTACTATAGTGGCTTAACAT
TTAATCTGTCTCCAATATTTTAACCAAGTGACACCGAGGTTTTTATCGAAGCATTTCACTTAAATGAACAAATCATGGCTGTTATATTAA
CTTGAAATAAAATATATTTAAACATGTAGTTAACATGCTCTTTCTCATCATGAATTATAAAGGTGCCCAAATTATGGGTATCTTGATTTT
TTTCAAAAATTGGTTGTGTGAATCCAGCTCTTGCTTATGGCTGAGAATGTTCCTAAAGTTCATTTCACTATCCCTTAATCCTCAATAGCT
ACACATACCCCCTTGCCTAGTTAGTCTTGCACTGCTTTACAACTCTCTTAGGCAAATTACCTAACATAAGCTCCACAGAAGAGTTTTTTA
AAACTTAAAATCCCTGTCCCACCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATTGCTTGAGGC
CAGGAGTTCGAGACAAGCCTGACCAACATGGTGACTCCATCTCTACTAAAAATAAAAAATCAGCCAGGTGTGATGGTGGATGCCTATAAG
ATCCTAGCTGCTACTCAGGAGGCAGGAGGCTGAGGCATGAGAATCACTTGAACCTGTGAGGCAAAGGTTGTAGTGAGCCAAGATCACGTC
ACTGCACTCCATCCTGGGTGACAGAATGAGACTCTTGTCTCAAAAAACAAAAAAACCTATTTAGTTTCATCCAGGACATTAAGTGAAAGT
GTTTAATGTGAGTGCAGGTCAGTGAAGAATACAATGGTGCCCCTGCTTTGATTTGTGGGAGGTGCCATCAGTTTTCCCCACCACTGCTTT
TGCACCCTCAGTGCAAATATCAACACAGAGAAAAAAAAAATAATAATAGTATTATGAAAACATTGACTCTGTGGAGACCCTGTGGGTTCT
GCAGAGTATACTTTGAAAACTATAAGATTATGAGTTCTATAAAATACCAAGTACAGATGAACTAGAAAACAAGCATATATCCACAATTAC
CAGAATTTTCATAGTATTCCTTTTAGTAGATATGCCATGACAGTTACTTAGCCACCCCATGCCATCCTGTTGGGAATGCCACTACCTTTG
AATTTGGAGCCATCAGTCTATCTGAGGCAAACCTCAGAAATTACCTGAGCCAGAATCATGCACTTAGCACTGAGTTCAACTCAGTCTTAA
CGTTGCATTTTGTTGCATCACTTTTGCAGCCAGTAAACATTCTGTTTAGAAATAGTTGCTATTGTGGCATCATTCACAGTTGCAATTTTT
CTCCTGTGCTGTCATATGCCTGTGCGAAGTGTATTAAATGAATCAAATATTAGAAA

>17778_17778_1_CNOT6-CLTC_CNOT6_chr5_179991743_ENST00000261951_CLTC_chr17_57746137_ENST00000269122_length(amino acids)=1172AA_BP=206
MHSQGGGGGSGGGRRRTPRGMPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDI
AKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGT
AKRITTEQPPPRSWIMLQEPDRTRPTGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLP
LIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLE
ARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDP
ELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEY
INRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADD
PSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSN
FGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAH
MGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVEL
YYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNI
SLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVL
ETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQPGFGY
SM

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>17778_17778_2_CNOT6-CLTC_CNOT6_chr5_179991743_ENST00000261951_CLTC_chr17_57746137_ENST00000393043_length(transcript)=3798nt_BP=908nt
CAATGAAAACGAGGGGGGCGCGGAGGAGGAGGCGGCGGCGTCGGTGGCGGCGGCGACGGCGGCGCGGAGGCGAAGGCAGCGGCGGGCGCA
GCGAGGAGGGCGAGGCCGGGGGCCGAGAGGGCGGGAGGGCGTAGTGGCGGCCCGTCGGGGCGGCTGAGGCGGGCAGCCGAAGCAGTGGCT
CTCGGAGGGGGAACAAAGAGCAGCGACTAAGGCGGCAGAGGAGCGGCGGCGGTGGCGGCGCTGCAGCAGCGGGCGGGACTGGTATGGTGG
TTCCACAGGGCAGACCCCGCTGCACTCACAGGGAGGAGGAGGCGGCAGCGGCGGAGGAAGGCGGCGCACCCCGAGAGGCATGCCCAAAGA
AAAATACGAGCCCCCTGACCCTCGGAGGATGTATACAATTATGTCTTCTGAGGAAGCAGCAAATGGAAAGAAATCCCACTGGGCAGAGCT
TGAAATAAGTGGAAAAGTAAGAAGCTTAAGCGCATCTTTGTGGTCACTAACTCACCTGACAGCTTTGCATTTGAGTGACAATTCCCTGTC
CCGAATTCCTTCAGACATTGCCAAGCTTCACAATCTGGTGTATTTGGACCTGTCATCTAATAAAATTCGTAGCTTACCCGCAGAACTCGG
AAACATGGTATCACTCAGGGAGCTCCATTTAAATAACAACCTGTTACGAGTTCTACCTTTTGAGCTGGGAAAACTGTTTCAGTTGCAGAC
TTTAGGCCTGAAAGGAAATCCCCTTACCCAGGATATATTGAACCTTTATCAGGAACCAGATGGAACAAGACGGCTGCTGAACTATTTGCT
TGATAATTTGTCAGGTACTGCAAAAAGAATTACAACAGAACAACCACCTCCAAGGTCTTGGATTATGTTACAAGAACCAGATAGGACAAG
GCCAACTGGTCTCTTTTATTTTCTGGGATCCATTGTTAACTTTAGCCAGGACCCAGATGTGCACTTTAAATATATTCAGGCAGCTTGCAA
GACTGGGCAAATCAAAGAAGTAGAAAGAATCTGTAGAGAAAGCAACTGCTACGATCCTGAGCGAGTCAAGAATTTTCTTAAGGAAGCAAA
ACTAACAGATCAGCTACCACTTATCATTGTGTGTGATCGATTTGACTTTGTCCATGATTTGGTGCTCTATTTATATAGAAATAATCTTCA
AAAGTATATAGAGATATATGTACAGAAGGTGAATCCAAGTCGACTTCCTGTAGTTATTGGAGGATTACTTGATGTTGACTGTTCTGAAGA
TGTCATAAAAAACTTGATTCTTGTTGTAAGAGGTCAATTCTCTACTGATGAGCTTGTTGCTGAGGTTGAAAAAAGAAACAGATTGAAACT
GCTTCTGCCTTGGCTAGAGGCCAGAATTCATGAGGGCTGTGAGGAGCCTGCTACTCACAATGCCTTAGCCAAAATCTACATAGACAGTAA
TAACAACCCGGAGAGATTTCTTCGTGAAAATCCCTACTATGACAGTCGCGTTGTTGGAAAGTATTGTGAGAAGAGAGATCCACATCTGGC
CTGTGTTGCTTATGAACGTGGCCAATGTGATCTGGAACTTATTAATGTTTGCAATGAGAATTCCCTCTTCAAAAGTCTTTCTCGCTACCT
GGTACGTCGAAAGGATCCAGAATTGTGGGGCAGCGTGCTGCTGGAAAGCAATCCTTACAGGAGACCCCTAATTGACCAGGTTGTACAAAC
AGCTTTGTCTGAGACTCAGGACCCTGAAGAAGTGTCAGTAACTGTAAAGGCTTTCATGACTGCAGACCTTCCTAATGAACTCATTGAACT
GCTGGAGAAAATTGTCCTTGATAACTCTGTATTCAGTGAACACAGGAATCTGCAAAACCTCCTTATCCTCACTGCAATTAAGGCTGACCG
TACACGTGTTATGGAGTATATTAACCGCCTGGATAATTATGATGCCCCAGATATTGCCAATATCGCCATCAGCAATGAGCTGTTTGAAGA
AGCATTTGCCATTTTCCGGAAATTTGATGTCAATACTTCAGCAGTTCAGGTCTTAATTGAGCATATTGGAAACTTGGATCGGGCATATGA
GTTTGCTGAACGTTGCAATGAACCTGCGGTCTGGAGTCAACTTGCAAAAGCCCAGTTGCAGAAAGGAATGGTGAAAGAAGCCATTGATTC
TTATATCAAAGCAGATGATCCTTCCTCCTACATGGAAGTTGTTCAGGCTGCCAATACTAGTGGAAACTGGGAAGAACTGGTGAAGTACTT
GCAGATGGCCCGTAAGAAGGCTCGAGAGTCCTATGTGGAGACAGAACTGATATTCGCACTGGCTAAAACAAACCGCCTTGCAGAGTTAGA
AGAATTTATCAATGGACCAAATAATGCTCATATCCAACAAGTTGGTGACCGTTGTTATGATGAAAAAATGTATGATGCTGCTAAGTTGTT
GTACAATAATGTTTCCAATTTTGGACGTTTGGCATCTACCCTGGTTCACCTGGGTGAATATCAGGCAGCTGTTGATGGGGCTAGGAAAGC
TAACAGTACTCGAACATGGAAAGAGGTCTGCTTCGCCTGTGTAGATGGGAAAGAATTCCGTCTTGCTCAGATGTGTGGACTTCATATTGT
TGTACATGCAGATGAATTAGAAGAACTTATCAACTACTATCAGGATCGTGGCTATTTTGAAGAGCTGATCACCATGTTGGAAGCAGCACT
GGGACTTGAGCGAGCTCACATGGGAATGTTTACTGAATTAGCTATTCTATACTCTAAATTTAAGCCTCAGAAAATGAGGGAGCACCTGGA
GCTGTTCTGGTCTAGAGTGAATATTCCCAAGGTGCTAAGAGCTGCAGAACAAGCTCATCTTTGGGCAGAACTGGTGTTTTTGTATGACAA
GTATGAAGAATATGATAATGCCATAATTACCATGATGAATCATCCAACTGATGCCTGGAAAGAAGGGCAATTCAAAGATATCATTACCAA
GGTTGCCAATGTGGAACTATACTACAGAGCAATACAGTTCTACTTAGAATTCAAGCCTCTGTTGTTAAATGATTTGCTGATGGTGCTGTC
TCCACGGTTGGATCACACTCGTGCAGTCAATTATTTCAGCAAGGTTAAACAGCTACCACTGGTGAAACCGTATTTGCGTTCAGTTCAGAA
CCATAACAACAAATCTGTGAATGAATCATTGAACAATCTTTTTATTACAGAAGAAGATTATCAGGCTCTGCGAACATCAATAGATGCTTA
TGACAACTTTGACAATATCTCGCTTGCTCAGCGTTTGGAAAAACATGAACTCATTGAGTTCAGGAGAATTGCTGCTTATCTCTTCAAAGG
CAACAATCGCTGGAAACAGAGTGTAGAGCTGTGCAAGAAAGACAGCCTTTACAAGGATGCAATGCAGTATGCTTCTGAATCTAAAGATAC
TGAATTGGCTGAAGAACTCCTGCAGTGGTTTTTGCAGGAAGAAAAAAGAGAGTGCTTTGGAGCTTGTCTGTTTACCTGTTACGATCTTTT
AAGGCCAGATGTCGTCCTAGAAACTGCATGGAGGCACAATATCATGGATTTTGCCATGCCCTATTTCATCCAGGTCATGAAGGAGTACTT
GACAAAGGTGGATAAATTAGATGCTTCAGAATCACTGAGAAAAGAAGAAGAACAAGCTACAGAGACACAACCCATTGTTTATGGTAATCT
CTCTCTGTAACCTCAAAAAATTCATTAGACAAATATTTAATTACTTAGAGACTGTGCCTCAAAATAGAATACAACAAGCTTCTAAAGTGC
AAAAGGCTTTCTAAGAAA

>17778_17778_2_CNOT6-CLTC_CNOT6_chr5_179991743_ENST00000261951_CLTC_chr17_57746137_ENST00000393043_length(amino acids)=1136AA_BP=206
MHSQGGGGGSGGGRRRTPRGMPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDI
AKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGT
AKRITTEQPPPRSWIMLQEPDRTRPTGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLP
LIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLE
ARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDP
ELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEY
INRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADD
PSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSN
FGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAH
MGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVEL
YYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNI
SLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVL
ETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGNLSL

--------------------------------------------------------------
>17778_17778_3_CNOT6-CLTC_CNOT6_chr5_179991743_ENST00000393356_CLTC_chr17_57746137_ENST00000269122_length(transcript)=6341nt_BP=983nt
GGCGCGGAGGAGGAGGCGGCGGCGTCGGTGGCGGCGGCGACGGCGGCGCGGAGGCGAAGGCAGCGGCGGGCAGCCGAAGCAGTGGCTCTC
GGAGGGGGAACAAAGAGCAGCGACTAAGGCGGCAGAGGAGCGGCGGCGGTGGCGGCGCTGCAGCAGCGGGCGGGACTGGTATGGTGGTTC
CACAGGGCAGACCCCGCTGCACTCACAGGGAGGAGGAGGCGGCAGCGGCGGAGGAAGGCGGCGCACCCCGAGAGCACTAATCGCTATTTT
CTTTGGAAACTTCCTTTGATTCTTTACCTCCTTCACCTTCCCCGAAGAGCCTGCTAACCAACACCTGTGGCCTTCTGTTTTTAACTGTTG
TTGCCATTGACAGCGTTGTGAATGGTCATCTCGCTCGAGCTCTTTGGATTTGTTGTTACTGTGCATGCCCAAAGAAAAATACGAGCCCCC
TGACCCTCGGAGGATGTATACAATTATGTCTTCTGAGGAAGCAGCAAATGGAAAGAAATCCCACTGGGCAGAGCTTGAAATAAGTGGAAA
AGTAAGAAGCTTAAGCGCATCTTTGTGGTCACTAACTCACCTGACAGCTTTGCATTTGAGTGACAATTCCCTGTCCCGAATTCCTTCAGA
CATTGCCAAGCTTCACAATCTGGTGTATTTGGACCTGTCATCTAATAAAATTCGTAGCTTACCCGCAGAACTCGGAAACATGGTATCACT
CAGGGAGCTCCATTTAAATAACAACCTGTTACGAGTTCTACCTTTTGAGCTGGGAAAACTGTTTCAGTTGCAGACTTTAGGCCTGAAAGG
AAATCCCCTTACCCAGGATATATTGAACCTTTATCAGGAACCAGATGGAACAAGACGGCTGCTGAACTATTTGCTTGATAATTTGTCAGG
TACTGCAAAAAGAATTACAACAGAACAACCACCTCCAAGGTCTTGGATTATGTTACAAGAACCAGATAGGACAAGGCCAACTGGTCTCTT
TTATTTTCTGGGATCCATTGTTAACTTTAGCCAGGACCCAGATGTGCACTTTAAATATATTCAGGCAGCTTGCAAGACTGGGCAAATCAA
AGAAGTAGAAAGAATCTGTAGAGAAAGCAACTGCTACGATCCTGAGCGAGTCAAGAATTTTCTTAAGGAAGCAAAACTAACAGATCAGCT
ACCACTTATCATTGTGTGTGATCGATTTGACTTTGTCCATGATTTGGTGCTCTATTTATATAGAAATAATCTTCAAAAGTATATAGAGAT
ATATGTACAGAAGGTGAATCCAAGTCGACTTCCTGTAGTTATTGGAGGATTACTTGATGTTGACTGTTCTGAAGATGTCATAAAAAACTT
GATTCTTGTTGTAAGAGGTCAATTCTCTACTGATGAGCTTGTTGCTGAGGTTGAAAAAAGAAACAGATTGAAACTGCTTCTGCCTTGGCT
AGAGGCCAGAATTCATGAGGGCTGTGAGGAGCCTGCTACTCACAATGCCTTAGCCAAAATCTACATAGACAGTAATAACAACCCGGAGAG
ATTTCTTCGTGAAAATCCCTACTATGACAGTCGCGTTGTTGGAAAGTATTGTGAGAAGAGAGATCCACATCTGGCCTGTGTTGCTTATGA
ACGTGGCCAATGTGATCTGGAACTTATTAATGTTTGCAATGAGAATTCCCTCTTCAAAAGTCTTTCTCGCTACCTGGTACGTCGAAAGGA
TCCAGAATTGTGGGGCAGCGTGCTGCTGGAAAGCAATCCTTACAGGAGACCCCTAATTGACCAGGTTGTACAAACAGCTTTGTCTGAGAC
TCAGGACCCTGAAGAAGTGTCAGTAACTGTAAAGGCTTTCATGACTGCAGACCTTCCTAATGAACTCATTGAACTGCTGGAGAAAATTGT
CCTTGATAACTCTGTATTCAGTGAACACAGGAATCTGCAAAACCTCCTTATCCTCACTGCAATTAAGGCTGACCGTACACGTGTTATGGA
GTATATTAACCGCCTGGATAATTATGATGCCCCAGATATTGCCAATATCGCCATCAGCAATGAGCTGTTTGAAGAAGCATTTGCCATTTT
CCGGAAATTTGATGTCAATACTTCAGCAGTTCAGGTCTTAATTGAGCATATTGGAAACTTGGATCGGGCATATGAGTTTGCTGAACGTTG
CAATGAACCTGCGGTCTGGAGTCAACTTGCAAAAGCCCAGTTGCAGAAAGGAATGGTGAAAGAAGCCATTGATTCTTATATCAAAGCAGA
TGATCCTTCCTCCTACATGGAAGTTGTTCAGGCTGCCAATACTAGTGGAAACTGGGAAGAACTGGTGAAGTACTTGCAGATGGCCCGTAA
GAAGGCTCGAGAGTCCTATGTGGAGACAGAACTGATATTCGCACTGGCTAAAACAAACCGCCTTGCAGAGTTAGAAGAATTTATCAATGG
ACCAAATAATGCTCATATCCAACAAGTTGGTGACCGTTGTTATGATGAAAAAATGTATGATGCTGCTAAGTTGTTGTACAATAATGTTTC
CAATTTTGGACGTTTGGCATCTACCCTGGTTCACCTGGGTGAATATCAGGCAGCTGTTGATGGGGCTAGGAAAGCTAACAGTACTCGAAC
ATGGAAAGAGGTCTGCTTCGCCTGTGTAGATGGGAAAGAATTCCGTCTTGCTCAGATGTGTGGACTTCATATTGTTGTACATGCAGATGA
ATTAGAAGAACTTATCAACTACTATCAGGATCGTGGCTATTTTGAAGAGCTGATCACCATGTTGGAAGCAGCACTGGGACTTGAGCGAGC
TCACATGGGAATGTTTACTGAATTAGCTATTCTATACTCTAAATTTAAGCCTCAGAAAATGAGGGAGCACCTGGAGCTGTTCTGGTCTAG
AGTGAATATTCCCAAGGTGCTAAGAGCTGCAGAACAAGCTCATCTTTGGGCAGAACTGGTGTTTTTGTATGACAAGTATGAAGAATATGA
TAATGCCATAATTACCATGATGAATCATCCAACTGATGCCTGGAAAGAAGGGCAATTCAAAGATATCATTACCAAGGTTGCCAATGTGGA
ACTATACTACAGAGCAATACAGTTCTACTTAGAATTCAAGCCTCTGTTGTTAAATGATTTGCTGATGGTGCTGTCTCCACGGTTGGATCA
CACTCGTGCAGTCAATTATTTCAGCAAGGTTAAACAGCTACCACTGGTGAAACCGTATTTGCGTTCAGTTCAGAACCATAACAACAAATC
TGTGAATGAATCATTGAACAATCTTTTTATTACAGAAGAAGATTATCAGGCTCTGCGAACATCAATAGATGCTTATGACAACTTTGACAA
TATCTCGCTTGCTCAGCGTTTGGAAAAACATGAACTCATTGAGTTCAGGAGAATTGCTGCTTATCTCTTCAAAGGCAACAATCGCTGGAA
ACAGAGTGTAGAGCTGTGCAAGAAAGACAGCCTTTACAAGGATGCAATGCAGTATGCTTCTGAATCTAAAGATACTGAATTGGCTGAAGA
ACTCCTGCAGTGGTTTTTGCAGGAAGAAAAAAGAGAGTGCTTTGGAGCTTGTCTGTTTACCTGTTACGATCTTTTAAGGCCAGATGTCGT
CCTAGAAACTGCATGGAGGCACAATATCATGGATTTTGCCATGCCCTATTTCATCCAGGTCATGAAGGAGTACTTGACAAAGGTGGATAA
ATTAGATGCTTCAGAATCACTGAGAAAAGAAGAAGAACAAGCTACAGAGACACAACCCATTGTTTATGGTCAGCCCCAGTTGATGCTGAC
AGCAGGACCCAGTGTTGCCGTCCCTCCCCAGGCACCTTTTGGTTATGGTTATACCGCACCACCGTATGGACAGCCACAGCCTGGCTTTGG
GTACAGCATGTGAGATGAAGCGCTGATCCTGTAGTCACCTATTTTCGTACTGAAACATCGTCTTTACCCACTTCTCAGTTTATAATGGGG
GAAAACAGGCAACGTGTTCTTGTAACCTTTATTTCATGAAGGACTTCTTTTTGTTTCTAACTATAAACTTGGATCACCTATGTTAAAACC
TTATTTCACATTCCACATCATTTTAGAATTTATTTTCGAAGGGGAATAGTTTCAATGTTTTATTCACTTGGGCTTTTTTTCTTCCCCCTC
TTTCTTTAAAGAACTGCTCAATATTCAATCTGTTGTGAAGAACCTGATTTGCACTCTGTAGTGTTTAAAGAAACAAAGAAACTCTAATAT
TGAATCTCTTAAATTTAGTGTATGTAAACAGCTTACAAATACGTATTGTCTAAATGCATTTAAATCTGTTTTATTCAAAGAAAAGCTAAA
GCAAAAACACTGGCATATGACCATGCAAGACTGTCAGTGCCAACAAAGACAACACTAATCAGCACATCGTACACTGGATTGCAGTGCTTC
CCAGATTATTGAAAAATGTTACAGACAACTTGCCTGATTTTTAAATGAGCGTAAAAGGCCCTCTAACCTATGCAGGTTTCCCCATTATGC
ATATAGAAAATGCTAGTATGTTTTGCTCACTTCATATGTAACAGGTGCCCTTATGTTGTGCTGTATCCTGTGCTTTTTCTGTGGGACCAT
TCCATTCAGGAGCAAAGAGCACCATGATTCCAATCTTGTGTGTGTTTACTAACCCTTCCCTGAGGTTTGTGTATGTTGGATATTGTGGTG
TTTTAGATCACTGAGTGTACAGAAGAGAGAAATTCAAACAAAATATTGCTGTTCTTCAGTTTTGTTTGTGGAATTTGAAATTACTCAAAT
TTAAAATAAATTACTGGACTGTGGAAATAACATAGAATTGAAGTTTTAATTAAATACCACTCAAACGAAAAGAACAGTAGTTTTTGTAGT
TTTATATTGGATACTGAGGCATTAGGGAGGCATGAAAGGAAGAGGAATGAGGATTGAGACATGTGAAGACATTGTGCATTATATCAATGT
GCATTCCTGTAGTTCATTAACAAGGTACATGCAATAGTCTAAAGAACCAGAGTCACTACTATAGTGGCTTAACATTTAATCTGTCTCCAA
TATTTTAACCAAGTGACACCGAGGTTTTTATCGAAGCATTTCACTTAAATGAACAAATCATGGCTGTTATATTAACTTGAAATAAAATAT
ATTTAAACATGTAGTTAACATGCTCTTTCTCATCATGAATTATAAAGGTGCCCAAATTATGGGTATCTTGATTTTTTTCAAAAATTGGTT
GTGTGAATCCAGCTCTTGCTTATGGCTGAGAATGTTCCTAAAGTTCATTTCACTATCCCTTAATCCTCAATAGCTACACATACCCCCTTG
CCTAGTTAGTCTTGCACTGCTTTACAACTCTCTTAGGCAAATTACCTAACATAAGCTCCACAGAAGAGTTTTTTAAAACTTAAAATCCCT
GTCCCACCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATTGCTTGAGGCCAGGAGTTCGAGACA
AGCCTGACCAACATGGTGACTCCATCTCTACTAAAAATAAAAAATCAGCCAGGTGTGATGGTGGATGCCTATAAGATCCTAGCTGCTACT
CAGGAGGCAGGAGGCTGAGGCATGAGAATCACTTGAACCTGTGAGGCAAAGGTTGTAGTGAGCCAAGATCACGTCACTGCACTCCATCCT
GGGTGACAGAATGAGACTCTTGTCTCAAAAAACAAAAAAACCTATTTAGTTTCATCCAGGACATTAAGTGAAAGTGTTTAATGTGAGTGC
AGGTCAGTGAAGAATACAATGGTGCCCCTGCTTTGATTTGTGGGAGGTGCCATCAGTTTTCCCCACCACTGCTTTTGCACCCTCAGTGCA
AATATCAACACAGAGAAAAAAAAAATAATAATAGTATTATGAAAACATTGACTCTGTGGAGACCCTGTGGGTTCTGCAGAGTATACTTTG
AAAACTATAAGATTATGAGTTCTATAAAATACCAAGTACAGATGAACTAGAAAACAAGCATATATCCACAATTACCAGAATTTTCATAGT
ATTCCTTTTAGTAGATATGCCATGACAGTTACTTAGCCACCCCATGCCATCCTGTTGGGAATGCCACTACCTTTGAATTTGGAGCCATCA
GTCTATCTGAGGCAAACCTCAGAAATTACCTGAGCCAGAATCATGCACTTAGCACTGAGTTCAACTCAGTCTTAACGTTGCATTTTGTTG
CATCACTTTTGCAGCCAGTAAACATTCTGTTTAGAAATAGTTGCTATTGTGGCATCATTCACAGTTGCAATTTTTCTCCTGTGCTGTCAT
ATGCCTGTGCGAAGTGTATTAAATGAATCAAATATTAGAAA

>17778_17778_3_CNOT6-CLTC_CNOT6_chr5_179991743_ENST00000393356_CLTC_chr17_57746137_ENST00000269122_length(amino acids)=1159AA_BP=193
MDLLLLCMPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSS
NKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRS
WIMLQEPDRTRPTGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHD
LVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATH
NALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPY
RRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIA
NIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANT
SGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGE
YQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSK
FKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKP
LLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIE
FRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAM
PYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQPGFGYSM

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>17778_17778_4_CNOT6-CLTC_CNOT6_chr5_179991743_ENST00000393356_CLTC_chr17_57746137_ENST00000393043_length(transcript)=3873nt_BP=983nt
GGCGCGGAGGAGGAGGCGGCGGCGTCGGTGGCGGCGGCGACGGCGGCGCGGAGGCGAAGGCAGCGGCGGGCAGCCGAAGCAGTGGCTCTC
GGAGGGGGAACAAAGAGCAGCGACTAAGGCGGCAGAGGAGCGGCGGCGGTGGCGGCGCTGCAGCAGCGGGCGGGACTGGTATGGTGGTTC
CACAGGGCAGACCCCGCTGCACTCACAGGGAGGAGGAGGCGGCAGCGGCGGAGGAAGGCGGCGCACCCCGAGAGCACTAATCGCTATTTT
CTTTGGAAACTTCCTTTGATTCTTTACCTCCTTCACCTTCCCCGAAGAGCCTGCTAACCAACACCTGTGGCCTTCTGTTTTTAACTGTTG
TTGCCATTGACAGCGTTGTGAATGGTCATCTCGCTCGAGCTCTTTGGATTTGTTGTTACTGTGCATGCCCAAAGAAAAATACGAGCCCCC
TGACCCTCGGAGGATGTATACAATTATGTCTTCTGAGGAAGCAGCAAATGGAAAGAAATCCCACTGGGCAGAGCTTGAAATAAGTGGAAA
AGTAAGAAGCTTAAGCGCATCTTTGTGGTCACTAACTCACCTGACAGCTTTGCATTTGAGTGACAATTCCCTGTCCCGAATTCCTTCAGA
CATTGCCAAGCTTCACAATCTGGTGTATTTGGACCTGTCATCTAATAAAATTCGTAGCTTACCCGCAGAACTCGGAAACATGGTATCACT
CAGGGAGCTCCATTTAAATAACAACCTGTTACGAGTTCTACCTTTTGAGCTGGGAAAACTGTTTCAGTTGCAGACTTTAGGCCTGAAAGG
AAATCCCCTTACCCAGGATATATTGAACCTTTATCAGGAACCAGATGGAACAAGACGGCTGCTGAACTATTTGCTTGATAATTTGTCAGG
TACTGCAAAAAGAATTACAACAGAACAACCACCTCCAAGGTCTTGGATTATGTTACAAGAACCAGATAGGACAAGGCCAACTGGTCTCTT
TTATTTTCTGGGATCCATTGTTAACTTTAGCCAGGACCCAGATGTGCACTTTAAATATATTCAGGCAGCTTGCAAGACTGGGCAAATCAA
AGAAGTAGAAAGAATCTGTAGAGAAAGCAACTGCTACGATCCTGAGCGAGTCAAGAATTTTCTTAAGGAAGCAAAACTAACAGATCAGCT
ACCACTTATCATTGTGTGTGATCGATTTGACTTTGTCCATGATTTGGTGCTCTATTTATATAGAAATAATCTTCAAAAGTATATAGAGAT
ATATGTACAGAAGGTGAATCCAAGTCGACTTCCTGTAGTTATTGGAGGATTACTTGATGTTGACTGTTCTGAAGATGTCATAAAAAACTT
GATTCTTGTTGTAAGAGGTCAATTCTCTACTGATGAGCTTGTTGCTGAGGTTGAAAAAAGAAACAGATTGAAACTGCTTCTGCCTTGGCT
AGAGGCCAGAATTCATGAGGGCTGTGAGGAGCCTGCTACTCACAATGCCTTAGCCAAAATCTACATAGACAGTAATAACAACCCGGAGAG
ATTTCTTCGTGAAAATCCCTACTATGACAGTCGCGTTGTTGGAAAGTATTGTGAGAAGAGAGATCCACATCTGGCCTGTGTTGCTTATGA
ACGTGGCCAATGTGATCTGGAACTTATTAATGTTTGCAATGAGAATTCCCTCTTCAAAAGTCTTTCTCGCTACCTGGTACGTCGAAAGGA
TCCAGAATTGTGGGGCAGCGTGCTGCTGGAAAGCAATCCTTACAGGAGACCCCTAATTGACCAGGTTGTACAAACAGCTTTGTCTGAGAC
TCAGGACCCTGAAGAAGTGTCAGTAACTGTAAAGGCTTTCATGACTGCAGACCTTCCTAATGAACTCATTGAACTGCTGGAGAAAATTGT
CCTTGATAACTCTGTATTCAGTGAACACAGGAATCTGCAAAACCTCCTTATCCTCACTGCAATTAAGGCTGACCGTACACGTGTTATGGA
GTATATTAACCGCCTGGATAATTATGATGCCCCAGATATTGCCAATATCGCCATCAGCAATGAGCTGTTTGAAGAAGCATTTGCCATTTT
CCGGAAATTTGATGTCAATACTTCAGCAGTTCAGGTCTTAATTGAGCATATTGGAAACTTGGATCGGGCATATGAGTTTGCTGAACGTTG
CAATGAACCTGCGGTCTGGAGTCAACTTGCAAAAGCCCAGTTGCAGAAAGGAATGGTGAAAGAAGCCATTGATTCTTATATCAAAGCAGA
TGATCCTTCCTCCTACATGGAAGTTGTTCAGGCTGCCAATACTAGTGGAAACTGGGAAGAACTGGTGAAGTACTTGCAGATGGCCCGTAA
GAAGGCTCGAGAGTCCTATGTGGAGACAGAACTGATATTCGCACTGGCTAAAACAAACCGCCTTGCAGAGTTAGAAGAATTTATCAATGG
ACCAAATAATGCTCATATCCAACAAGTTGGTGACCGTTGTTATGATGAAAAAATGTATGATGCTGCTAAGTTGTTGTACAATAATGTTTC
CAATTTTGGACGTTTGGCATCTACCCTGGTTCACCTGGGTGAATATCAGGCAGCTGTTGATGGGGCTAGGAAAGCTAACAGTACTCGAAC
ATGGAAAGAGGTCTGCTTCGCCTGTGTAGATGGGAAAGAATTCCGTCTTGCTCAGATGTGTGGACTTCATATTGTTGTACATGCAGATGA
ATTAGAAGAACTTATCAACTACTATCAGGATCGTGGCTATTTTGAAGAGCTGATCACCATGTTGGAAGCAGCACTGGGACTTGAGCGAGC
TCACATGGGAATGTTTACTGAATTAGCTATTCTATACTCTAAATTTAAGCCTCAGAAAATGAGGGAGCACCTGGAGCTGTTCTGGTCTAG
AGTGAATATTCCCAAGGTGCTAAGAGCTGCAGAACAAGCTCATCTTTGGGCAGAACTGGTGTTTTTGTATGACAAGTATGAAGAATATGA
TAATGCCATAATTACCATGATGAATCATCCAACTGATGCCTGGAAAGAAGGGCAATTCAAAGATATCATTACCAAGGTTGCCAATGTGGA
ACTATACTACAGAGCAATACAGTTCTACTTAGAATTCAAGCCTCTGTTGTTAAATGATTTGCTGATGGTGCTGTCTCCACGGTTGGATCA
CACTCGTGCAGTCAATTATTTCAGCAAGGTTAAACAGCTACCACTGGTGAAACCGTATTTGCGTTCAGTTCAGAACCATAACAACAAATC
TGTGAATGAATCATTGAACAATCTTTTTATTACAGAAGAAGATTATCAGGCTCTGCGAACATCAATAGATGCTTATGACAACTTTGACAA
TATCTCGCTTGCTCAGCGTTTGGAAAAACATGAACTCATTGAGTTCAGGAGAATTGCTGCTTATCTCTTCAAAGGCAACAATCGCTGGAA
ACAGAGTGTAGAGCTGTGCAAGAAAGACAGCCTTTACAAGGATGCAATGCAGTATGCTTCTGAATCTAAAGATACTGAATTGGCTGAAGA
ACTCCTGCAGTGGTTTTTGCAGGAAGAAAAAAGAGAGTGCTTTGGAGCTTGTCTGTTTACCTGTTACGATCTTTTAAGGCCAGATGTCGT
CCTAGAAACTGCATGGAGGCACAATATCATGGATTTTGCCATGCCCTATTTCATCCAGGTCATGAAGGAGTACTTGACAAAGGTGGATAA
ATTAGATGCTTCAGAATCACTGAGAAAAGAAGAAGAACAAGCTACAGAGACACAACCCATTGTTTATGGTAATCTCTCTCTGTAACCTCA
AAAAATTCATTAGACAAATATTTAATTACTTAGAGACTGTGCCTCAAAATAGAATACAACAAGCTTCTAAAGTGCAAAAGGCTTTCTAAG
AAA

>17778_17778_4_CNOT6-CLTC_CNOT6_chr5_179991743_ENST00000393356_CLTC_chr17_57746137_ENST00000393043_length(amino acids)=1123AA_BP=193
MDLLLLCMPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSS
NKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRS
WIMLQEPDRTRPTGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHD
LVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATH
NALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPY
RRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIA
NIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANT
SGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGE
YQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSK
FKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKP
LLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIE
FRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAM
PYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGNLSL

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Fusion Gene PPI Analysis for CNOT6-CLTC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CNOT6-CLTC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CNOT6-CLTC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4518356MiT family translocation renal cell carcinoma2ORPHANET
TgeneC4693389MENTAL RETARDATION, AUTOSOMAL DOMINANT 562GENOMICS_ENGLAND;UNIPROT
TgeneC0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneC0334121Inflammatory Myofibroblastic Tumor1ORPHANET