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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:COG6-STXBP4 (FusionGDB2 ID:HG57511TG252983)

Fusion Gene Summary for COG6-STXBP4

check button Fusion gene summary
Fusion gene informationFusion gene name: COG6-STXBP4
Fusion gene ID: hg57511tg252983
HgeneTgene
Gene symbol

COG6

STXBP4

Gene ID

57511

252983

Gene namecomponent of oligomeric golgi complex 6syntaxin binding protein 4
SynonymsCDG2L|COD2|SHNSSynip
Cytomap('COG6')('STXBP4')

13q14.11

17q22

Type of geneprotein-codingprotein-coding
Descriptionconserved oligomeric Golgi complex subunit 6COG complex subunit 6complexed with Dor1p 2conserved oligomeric Golgi complex protein 6testicular tissue protein Li 41syntaxin-binding protein 4STX4-interacting proteinsyntaxin 4 interacting protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000416691, ENST00000455146, 
ENST00000465775, 
Fusion gene scores* DoF score8 X 7 X 6=33615 X 12 X 9=1620
# samples 816
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1620*10)=-3.33985000288463
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COG6 [Title/Abstract] AND STXBP4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCOG6(40235018)-STXBP4(53108529), # samples:1
Anticipated loss of major functional domain due to fusion event.COG6-STXBP4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
COG6-STXBP4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
COG6-STXBP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
COG6-STXBP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTXBP4

GO:0006974

cellular response to DNA damage stimulus

19451233

TgeneSTXBP4

GO:0061178

regulation of insulin secretion involved in cellular response to glucose stimulus

12855681


check buttonFusion gene breakpoints across COG6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across STXBP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-AG-3731-01ACOG6chr13

40235018

-STXBP4chr17

53108529

+


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Fusion Gene ORF analysis for COG6-STXBP4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000416691ENST00000299341COG6chr13

40235018

-STXBP4chr17

53108529

+
In-frameENST00000416691ENST00000376352COG6chr13

40235018

-STXBP4chr17

53108529

+
In-frameENST00000416691ENST00000398391COG6chr13

40235018

-STXBP4chr17

53108529

+
In-frameENST00000416691ENST00000405898COG6chr13

40235018

-STXBP4chr17

53108529

+
In-frameENST00000416691ENST00000434978COG6chr13

40235018

-STXBP4chr17

53108529

+
In-frameENST00000455146ENST00000299341COG6chr13

40235018

-STXBP4chr17

53108529

+
In-frameENST00000455146ENST00000376352COG6chr13

40235018

-STXBP4chr17

53108529

+
In-frameENST00000455146ENST00000398391COG6chr13

40235018

-STXBP4chr17

53108529

+
In-frameENST00000455146ENST00000405898COG6chr13

40235018

-STXBP4chr17

53108529

+
In-frameENST00000455146ENST00000434978COG6chr13

40235018

-STXBP4chr17

53108529

+
intron-3CDSENST00000465775ENST00000299341COG6chr13

40235018

-STXBP4chr17

53108529

+
intron-3CDSENST00000465775ENST00000376352COG6chr13

40235018

-STXBP4chr17

53108529

+
intron-3CDSENST00000465775ENST00000398391COG6chr13

40235018

-STXBP4chr17

53108529

+
intron-3CDSENST00000465775ENST00000405898COG6chr13

40235018

-STXBP4chr17

53108529

+
intron-3CDSENST00000465775ENST00000434978COG6chr13

40235018

-STXBP4chr17

53108529

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000416691COG6chr1340235018-ENST00000299341STXBP4chr1753108529+7664691765255
ENST00000416691COG6chr1340235018-ENST00000376352STXBP4chr1753108529+583946911464487
ENST00000416691COG6chr1340235018-ENST00000405898STXBP4chr1753108529+19134691765254
ENST00000416691COG6chr1340235018-ENST00000434978STXBP4chr1753108529+241446911398465
ENST00000416691COG6chr1340235018-ENST00000398391STXBP4chr1753108529+19134691765254
ENST00000455146COG6chr1340235018-ENST00000299341STXBP4chr1753108529+71641911715235
ENST00000455146COG6chr1340235018-ENST00000376352STXBP4chr1753108529+5789419111414467
ENST00000455146COG6chr1340235018-ENST00000405898STXBP4chr1753108529+186341911715234
ENST00000455146COG6chr1340235018-ENST00000434978STXBP4chr1753108529+2364419111348445
ENST00000455146COG6chr1340235018-ENST00000398391STXBP4chr1753108529+186341911715234

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000416691ENST00000299341COG6chr1340235018-STXBP4chr1753108529+0.0043214840.9956785
ENST00000416691ENST00000376352COG6chr1340235018-STXBP4chr1753108529+0.0002742670.99972576
ENST00000416691ENST00000405898COG6chr1340235018-STXBP4chr1753108529+0.0008329150.9991671
ENST00000416691ENST00000434978COG6chr1340235018-STXBP4chr1753108529+0.0016287350.9983713
ENST00000416691ENST00000398391COG6chr1340235018-STXBP4chr1753108529+0.0008329150.9991671
ENST00000455146ENST00000299341COG6chr1340235018-STXBP4chr1753108529+0.0029122590.9970878
ENST00000455146ENST00000376352COG6chr1340235018-STXBP4chr1753108529+0.000404640.99959534
ENST00000455146ENST00000405898COG6chr1340235018-STXBP4chr1753108529+0.0005449970.99945503
ENST00000455146ENST00000434978COG6chr1340235018-STXBP4chr1753108529+0.0015779290.998422
ENST00000455146ENST00000398391COG6chr1340235018-STXBP4chr1753108529+0.0005449970.99945503

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Fusion Genomic Features for COG6-STXBP4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for COG6-STXBP4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:40235018/chr17:53108529)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTXBP4chr13:40235018chr17:53108529ENST00000299341712291_417147246.0Coiled coilOntology_term=ECO:0000255
TgeneSTXBP4chr13:40235018chr17:53108529ENST00000376352718291_417222554.0Coiled coilOntology_term=ECO:0000255
TgeneSTXBP4chr13:40235018chr17:53108529ENST00000398391611291_417147246.0Coiled coilOntology_term=ECO:0000255
TgeneSTXBP4chr13:40235018chr17:53108529ENST00000299341712496_529147246.0DomainWW
TgeneSTXBP4chr13:40235018chr17:53108529ENST00000376352718496_529222554.0DomainWW
TgeneSTXBP4chr13:40235018chr17:53108529ENST00000398391611496_529147246.0DomainWW

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTXBP4chr13:40235018chr17:53108529ENST0000029934171219_105147246.0DomainPDZ
TgeneSTXBP4chr13:40235018chr17:53108529ENST0000037635271819_105222554.0DomainPDZ
TgeneSTXBP4chr13:40235018chr17:53108529ENST0000039839161119_105147246.0DomainPDZ


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Fusion Gene Sequence for COG6-STXBP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>18039_18039_1_COG6-STXBP4_COG6_chr13_40235018_ENST00000416691_STXBP4_chr17_53108529_ENST00000299341_length(transcript)=766nt_BP=469nt
GATGCGCATGCGCGGCCGATTTGCACATGCGCAATACTCGCGCTGCCTCCGTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGAC
GCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGAC
CTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCT
CAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAA
TGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGA
TATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGA
CTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACA
TGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGA

>18039_18039_1_COG6-STXBP4_COG6_chr13_40235018_ENST00000416691_STXBP4_chr17_53108529_ENST00000299341_length(amino acids)=255AA_BP=155
MRMRGRFAHAQYSRCLRGPCLAEVAAGGGTRSAMAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEAL
KALSTFFVENSLRTRRNLRGDIERKSLAINEEFVSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQAD

--------------------------------------------------------------
>18039_18039_2_COG6-STXBP4_COG6_chr13_40235018_ENST00000416691_STXBP4_chr17_53108529_ENST00000376352_length(transcript)=5839nt_BP=469nt
GATGCGCATGCGCGGCCGATTTGCACATGCGCAATACTCGCGCTGCCTCCGTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGAC
GCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGAC
CTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCT
CAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAA
TGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGA
TATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGA
CTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACA
TGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGA
TGCCTTGAAAGAAGTAAATACACTTAAGGAAAAATTATTGGAATCAGATAAGCAAAGGAAACAATTGACAGAAGAGCTCCAGAATGTGAA
ACAAGAAGCCAAAGCTGTAGTTGAAGAAACAAGAGCCCTGCGTAGTCGGATTCATCTTGCTGAAGCTGCTCAGAGACAGGCACATGGAAT
GGAAATGGACTATGAAGAAGTGATCCGTCTGTTAGAGGCCAAGATTACAGAGCTAAAGGCTCAGCTTGCTGATTATTCTGACCAAAATAA
AGAAAGTGTTCAGGATTTAAAAAAGAGAATCATGGTACTCGACTGCCAATTACGAAAATCAGAAATGGCTCGAAAAACTTTTGAGGCATC
CACTGAAAAGCTTCTTCATTTTGTAGAGGCTATTCAAGAAGTATTTTCTGATAATTCTACTCCTTTATCAAATTTAAGTGAAAGAAGAGC
TGTGTTAGCTTCTCAGACTTCCCTCACACCACTGGGAAGGAATGGACGTAGCATCCCAGCAACGCTGGCGCTTGAATCTAAGGAACTTGT
TAAATCTGTTCGTGCCTTACTTGATATGGATTGTTTACCTTATGGGTGGGAGGAAGCTTACACAGCAGATGGAATCAAGTACTTCATCAA
TCATGTAACACAGACTACATCCTGGATCCATCCCGTGATGAGTGTCCTGAATCTATCTCGCTCAGAGGAGAATGAAGAGGATTGCTCTAG
AGAACTCCCCAACCAGAAAAGTTGATGGTTTTCCTTAGGAAGTGGAGCTACATGGATGATGTGAGCAGAGACGCATAACATCCAATTCTG
AGATGAAACAGTCTAAAATAGGAGTAAAGCATGCACTACTTGTTGAAGTGTGAAATGGAGACTCTGGACTTTGGGTATTTTTGTAAAACT
TTTGATATTTCTGTATACATTTAAAAAATCAATTGCCACTACAGTAGTTCCTTAAGAATAATCTAGTTATATTTTTTGAAATCACATATA
ATTAGACTTTATAATATATATACTTTTTCATATATAATTAGATCTTTCTTTGTAATTTCATATGTAGTTCTTCATAGGGTCTCAGATACA
ATGGTTTTTATAATTGACATATTGAAAAAGTATATGAACATAATGAAACACCTCATTTATTTGATAATTCACTAATGTTTTATATTCATA
TATTAGGAAAGTGAACTTAGCAAGCTTTTTGGAATTTAAGGATCACATTTAGACATCTCATGGGCTGATGAATACAGCTGGTATCTTTGT
GGAGCTTTCTAATTTACAAAATGCTTTGTAGACCCCATTGTCTTTAAACCATACAACATGCCCGTGAAGCTGATCTGGTGGGTATGTTTA
TTCTTGGTTTTCAGTAGGGAAATAGCAGTTCAGAGAGAGGAAGCTCTCTGTCCCAGCACCGAGACTCACTCCTAAGTCTTCTGATTCCAT
GAGCAGTCCCCCTTCCCCCATACCCTGCTGTCTCCACGGAGGGAGGTCACAGCCCATCACGCAGGACACTGTGATTGTGTTGATGCAGCT
GGCTCCACAGCTGTGCATTCCACAGAGATTCAGAAGGCACCTCTTCGGTCAAACATGGCCCCTCTATAACCCCACTATTCTTCTCCTATA
AACCCTTCCCCCTTCTCTGCACCCAAGCCTTCGCCAAGTAGGCGCACTCTTTGTGATATTGTTTCAGCAGACTTCTTTCAGCAGCTCGTG
TTTTTCTAAAGTGAAAGGCATGGTTTGTCCTGCTTAGGTTGCCCTTCCCAGAGGGATGGTTTGAGGGGAGCTGATGAGAAGAGAGGTATC
TGTTAAAACATTACTGCTCTACTCGAAACAAGATGGAAGCCTAAAGCCCAAGTCGAGCAGCTCCCAGCACTGCTGTGCAGACCTAGAGGT
CCTTAGAACATAGTCTAAGAACCATTCATTGTAGCCATTTTATAGTTGAGTAAACTGAGATCTTAAGTCTCCTAGTCTACTGAATTTCAT
ATGGTGTATAATACAGATTTATATGGTAAAGATATACATATACATTGTGCTCAACTATACATTCCTGAATCCATTTAGGATTTGTGATTT
ATGTCTTGAGTAATAATATAAAGTCAACTCCAGACTGATAGGTAGTCATTAGCCATGAGAAATGTTTCAGGATGGCTAGGGAAGACTTGT
GTTTTGCCTGACAGCCATTTGAATGTTAGGAAGCTTCGGGGAGACAAGTTTTGAGAGAAGCCCCAGAGGGAGCTATTTCCTTGCACCCCC
CAGAGGTGAATGAGGTATTCTATAAGTTAGTGTCTATAATTGTGAAAGTACAAACTTCTTGTTTTTGTCAAATTAATGGTATGAAATTTC
TCTCCCCCTGCTTGAAGAGTTTTCTAATTCGTTTCTAGTGAGCAAAACAAAGAAGGTGCTTGAGTCACTGAAATCAAAGTACTCAGGCAC
ACAGCCCACTGACAAGAGACACCTCATCCATTAACTGCTGTTTTGTACCACTTGCCGCCCTGTTTCTGTCAAATACCTAGTGAAAAAGGC
CTAAACAATTGTAATGATATTATTTATTGGGCATTTTGTGCCATACATGGTGATGAGCAGTTTGCATATATTTATTTATGATCTTCTTAA
AACCATTCCATGAAATAGGAACTGTAATTATCCCCAATTCTAAAAGAAAAAACTTAGTTTTAGAGAGTTAGTAATCTTTGCCTAAGGGTC
ACAAAGCACCTATGTGTAGAAGCTAGGGTTCAAGGCAGATCTGTGATTCCAGAAGCTGTTCTCTAAACCACTATGGAGAACTGCTTAGAT
TCATTGTCTATGGGTACATTTTATAAAAAGGCAGATTCTAGTTCAGTGTCATAAGGAACTTTCTAGTAATTAGAGCTGATAAGAAAAGAA
TTCCCCAGGAGAAAATGGAAACACTATCCCAGCAATCTGAATTCCTTACTTGGGGAATGTTGCTGAGGAGGTTCAGTGTGTGAATGGACT
GAACCAGTTGGCCACTCTCTCAGATTCCCTCTTCATAAAGCTTCCGTGACTTCTAAACCATCAGGTCGGTGCCATAAGAGATGCTCAAAA
AAGCATGGTCAGGGCTTAGCAAGAATCCTTTTCCAGTGCAAATACGACCCTCATATTATGTTTTGGCGAGTAGCCAGTCTTTCTTTAACA
TCAATCAACCGTAGCAATGTGGTCATCACGAAGTCTTCATTGACTCACTGGCTTGGATTTTAGGGTTAGAAAATCTGAATGTTCTTATGT
CCTTCCGTCTCACTTTACTAGAGTGCCCAAGTTGACTCATCCTTACTCACTCATTCCCTCAAAATATTTATTGAGCACCAACAATGTCAC
AAGCACTGTGCTAAACACTGTGGTGAAGTAGAACAATTGCTAATCATTTCCTGGGTTCCACTTACTCTTGATTTAAAAAAAAAAAAACAA
CAAAAGAGTTTGTGTGTGGCCAGGACTAAACAGCTGCTTCTTAATTTTTGAATTTTAAAACTAATCTATTTTATTTAAAAAAAATCAAGT
ACTTTGGAAGTGAATAAAGTAAGAGATAGCCTGTCTCACTTTCCAGAGGTAGCAGTCACTAATACTGTGGTGAGTGATTTTACTCAAAGG
AAATCACACTATTAAGCAGCTTGGTTTTGACATGTTATGTTGTGGTCATCTTTTCATGTCAATACATAGATTAATCTTTTATTTCAAATG
TCTACATAAAATATCACTACCCACATAACCTATAATTTGTGTGGCCAGCAATTTATTGAACACTAAAATGTTTTAAGTTTTCTTATTGCT
AACAATGTCACAGTGAACATTTATATATTCATTAAATCCTTTTCCTCATGTATCTTTGCACTCTTGTGCTAGTATGTCTATAGTGTGAAT
ACATTCATAAATTTCTTGATCAAAGCTAGGTCAAAGTTACATTCATTTTAATTTTGGTACATATCCATAAATTCTCCATAAAAGTAGGAC
CAACTTACATTACCACCAATAGTGTATGTGAGCCTTATTTTTATGTATGATAGGACTTTTTTTAGTCCAAATGTTCCTATAGATTTTCTG
GGTTTTTTTTTTTTTTTTGTCCTTGGAAGAATAACCTTCCTTCCACCAAGTCCAAGAACCTGAGATTTTTAATCATTAGGTTTTAGATTT
CCTTTAGCAGCAGAGACTGACTTGCTGTATAGAGGGAAGTCAAGTAGTGACTAACTCACTATATGTCAAACACATCATTACTCTTCTCTT
TTCCTACTTTACATGTAATGGTTGCGAGGACCAACTTTCAAATGAGCTAACTTGGGTGAGACGTTCACTAAAGTACCAAGCACAATACAA
ATGCATCTTCGAGTTCTTTGGGCCTCACTTTCCCTATCTGAATAATAAGGATAGTAATCCCTTGCCTTTTCTCAAACCAGTTCAACTCAG
CAAACACTTCCTGAGCACCTGCTACATGCCAGGCAAAATGTGAAATTTGCATGCTATGAGGCTAAATGGTACTGATTCTCAAAACAAGGA
GCTCATAGTCTAAAACCATTTTTCTTTCTTTTTTTTCCCCCTAAACAACCTCTTAAAGGGGTAAGAAGTTAGGGGGTTGTTTATTAAGAA
CCCCTGAAGAGCAACCCTTTACCACTCTCTTAAATTTGAAAAATTCCAAAATAATATTAACACCTCTTGACTAGAAAAGGAAAAAAAAGG
AACATGCCGTATGAAGAGCCTCTCCAATAATAAATGCAAAGCAGCTGTCAAAATATAGAGTCAAGTGATACTTTCATAAAGTGTTTGCAC
AATTAGAAAATGTTATCCTTTTTCTCGGGAGAAATGGGACATTTTTATTTTCTCTGCTAAGTGAAATGCAACTTTTTGAAGAATCAACAC
GCTTGACATTTTTACAATGTACATAAAGAACTGAACTATTATTAAAACAACTTACACACTCCATTGCTTATAACTTTTGAGAGAATGAAA
AGAACCTTAAACAGAATGTGCCTGTGGAGCTTCGCTTTAGAAATGAAATACCCAAGGTGTTTTAACTACAACTGTCTACATGTAATAGTG

>18039_18039_2_COG6-STXBP4_COG6_chr13_40235018_ENST00000416691_STXBP4_chr17_53108529_ENST00000376352_length(amino acids)=487AA_BP=155
MRMRGRFAHAQYSRCLRGPCLAEVAAGGGTRSAMAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEAL
KALSTFFVENSLRTRRNLRGDIERKSLAINEEFVSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQAD
SKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVK
QEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEAS
TEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFIN

--------------------------------------------------------------
>18039_18039_3_COG6-STXBP4_COG6_chr13_40235018_ENST00000416691_STXBP4_chr17_53108529_ENST00000398391_length(transcript)=1913nt_BP=469nt
GATGCGCATGCGCGGCCGATTTGCACATGCGCAATACTCGCGCTGCCTCCGTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGAC
GCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGAC
CTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCT
CAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAA
TGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGA
TATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGA
CTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACA
TGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGA
TGCCTTGAAAGAAGTAAATACACTTAAGTGGCCAGGGCAGAATTAGATGAAGAGCCAATAAAGCAAGTCGTGGCAATTTTGGATCCTGTG
AGTTCTTTGGGAAATACATTTTTTTTCATGTGCAGGGCTATTCTTAAGGGACATCATGTTTTGCTAACGTAATTTGGAATTAATATTATT
TTAGAGAGGAAAAAAACACACATATCCCAAATATACTGTAACATTTTTCTTCTCTTTTTTTGTTTGTTTGGTTTTTTGATTCTTGTTTTT
GTTTTGTGTTTTTGAGACAGGGTCGCACTCTGTCGCCCAGGCTGGAGTGCAATACTGCAATCACGTCTCACTGCAGCCTCAACCTCCTGG
GTTCAAGTGATTCTCCCACCTCAACCTCCCAAGTAACTGGGACAACATGTCCATGCCACCATGCTCAACTAATTTTTTTTTAAATTTTTA
TTTTGTAGAGATGGTGTCTCACTATTTTGTTCAGACTGGTCTCAAACACCTGGGCTCAAATGACCCACCTACCTCAGCCTCTCAAAGTGC
TGGGATTACAGGTGTGAGCCACCATGTCTGGCCTTGATTCTCTTTATGTGGTTTCATTCTGTTTTTAGAAGAATATTACATTTAAATTAT
ATCCTAATTTTTATAGAAAGCTATATTTTCCAAATCTTTAGGAAAAGCAACATAACTACTTGATTTACCACTAATTCGTCATAGGCACAT
ATTTTTAAAATTATTTTATTAAATAAGGTATAGTATATTGATAATTATTTAATTTTTATTAAATAGAAAATATTTACACCAAAAGGAAAG
AAAATTTGTTTTGCTACCTTAGTTTTTATAATCTCAACCTCTAGAGGAAGCCATTGTTGCAAATATATTATTTATCTTTTCATAGATTTT
TCTCTACACAGAAAATTATATTTTTTAAAAATAGGCAGGGCATGATGGCTGACACCTTTAATCGCAGTACTTTGGGAGGCTGAGGCAAGA
GGATTACTTGAGCTCAGGAGTTTAACATCAGCCTGGGCAACATAGCAGGACCCCATCTCTACTATTTAAAACATAAAAACAAAAATAAAT
AAATATATGTATATGTGGGGACAGGGAGTATGTGAGAAATTTCTGTACTTTCCCTTCAATTTTGCTATGAATCCAAAACTGCTTCAAAAA

>18039_18039_3_COG6-STXBP4_COG6_chr13_40235018_ENST00000416691_STXBP4_chr17_53108529_ENST00000398391_length(amino acids)=254AA_BP=155
MRMRGRFAHAQYSRCLRGPCLAEVAAGGGTRSAMAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEAL
KALSTFFVENSLRTRRNLRGDIERKSLAINEEFVSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQAD

--------------------------------------------------------------
>18039_18039_4_COG6-STXBP4_COG6_chr13_40235018_ENST00000416691_STXBP4_chr17_53108529_ENST00000405898_length(transcript)=1913nt_BP=469nt
GATGCGCATGCGCGGCCGATTTGCACATGCGCAATACTCGCGCTGCCTCCGTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGAC
GCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGAC
CTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCT
CAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAA
TGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGA
TATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGA
CTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACA
TGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGA
TGCCTTGAAAGAAGTAAATACACTTAAGTGGCCAGGGCAGAATTAGATGAAGAGCCAATAAAGCAAGTCGTGGCAATTTTGGATCCTGTG
AGTTCTTTGGGAAATACATTTTTTTTCATGTGCAGGGCTATTCTTAAGGGACATCATGTTTTGCTAACGTAATTTGGAATTAATATTATT
TTAGAGAGGAAAAAAACACACATATCCCAAATATACTGTAACATTTTTCTTCTCTTTTTTTGTTTGTTTGGTTTTTTGATTCTTGTTTTT
GTTTTGTGTTTTTGAGACAGGGTCGCACTCTGTCGCCCAGGCTGGAGTGCAATACTGCAATCACGTCTCACTGCAGCCTCAACCTCCTGG
GTTCAAGTGATTCTCCCACCTCAACCTCCCAAGTAACTGGGACAACATGTCCATGCCACCATGCTCAACTAATTTTTTTTTAAATTTTTA
TTTTGTAGAGATGGTGTCTCACTATTTTGTTCAGACTGGTCTCAAACACCTGGGCTCAAATGACCCACCTACCTCAGCCTCTCAAAGTGC
TGGGATTACAGGTGTGAGCCACCATGTCTGGCCTTGATTCTCTTTATGTGGTTTCATTCTGTTTTTAGAAGAATATTACATTTAAATTAT
ATCCTAATTTTTATAGAAAGCTATATTTTCCAAATCTTTAGGAAAAGCAACATAACTACTTGATTTACCACTAATTCGTCATAGGCACAT
ATTTTTAAAATTATTTTATTAAATAAGGTATAGTATATTGATAATTATTTAATTTTTATTAAATAGAAAATATTTACACCAAAAGGAAAG
AAAATTTGTTTTGCTACCTTAGTTTTTATAATCTCAACCTCTAGAGGAAGCCATTGTTGCAAATATATTATTTATCTTTTCATAGATTTT
TCTCTACACAGAAAATTATATTTTTTAAAAATAGGCAGGGCATGATGGCTGACACCTTTAATCGCAGTACTTTGGGAGGCTGAGGCAAGA
GGATTACTTGAGCTCAGGAGTTTAACATCAGCCTGGGCAACATAGCAGGACCCCATCTCTACTATTTAAAACATAAAAACAAAAATAAAT
AAATATATGTATATGTGGGGACAGGGAGTATGTGAGAAATTTCTGTACTTTCCCTTCAATTTTGCTATGAATCCAAAACTGCTTCAAAAA

>18039_18039_4_COG6-STXBP4_COG6_chr13_40235018_ENST00000416691_STXBP4_chr17_53108529_ENST00000405898_length(amino acids)=254AA_BP=155
MRMRGRFAHAQYSRCLRGPCLAEVAAGGGTRSAMAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEAL
KALSTFFVENSLRTRRNLRGDIERKSLAINEEFVSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQAD

--------------------------------------------------------------
>18039_18039_5_COG6-STXBP4_COG6_chr13_40235018_ENST00000416691_STXBP4_chr17_53108529_ENST00000434978_length(transcript)=2414nt_BP=469nt
GATGCGCATGCGCGGCCGATTTGCACATGCGCAATACTCGCGCTGCCTCCGTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGAC
GCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGAC
CTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCT
CAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAA
TGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGA
TATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGA
CTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACA
TGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGA
TGCCTTGAAAGAAGTAAATACACTTAAGGAAGCCAAAGCTGTAGTTGAAGAAACAAGAGCCCTGCGTAGTCGGATTCATCTTGCTGAAGC
TGCTCAGAGACAGGCACATGGAATGGAAATGGACTATGAAGAAGTGATCCGTCTGTTAGAGGCCAAGATTACAGAGCTAAAGGCTCAGCT
TGCTGATTATTCTGACCAAAATAAAGAAAGTGTTCAGGATTTAAAAAAGAGAATCATGGTACTCGACTGCCAATTACGAAAATCAGAAAT
GGCTCGAAAAACTTTTGAGGCATCCACTGAAAAGCTTCTTCATTTTGTAGAGGCTATTCAAGAAGTATTTTCTGATAATTCTACTCCTTT
ATCAAATTTAAGTGAAAGAAGAGCTGTGTTAGCTTCTCAGACTTCCCTCACACCACTGGGAAGGAATGGACGTAGCATCCCAGCAACGCT
GGCGCTTGAATCTAAGGAACTTGTTAAATCTGTTCGTGCCTTACTTGATATGGATTGTTTACCTTATGGGTGGGAGGAAGCTTACACAGC
AGATGGAATCAAGTACTTCATCAATCATGTAACACAGACTACATCCTGGATCCATCCCGTGATGAGTGTCCTGAATCTATCTCGCTCAGA
GGAGAATGAAGAGGATTGCTCTAGAGAACTCCCCAACCAGAAAAGTTGATGGTTTTCCTTAGGAAGTGGAGCTACATGGATGATGTGAGC
AGAGACGCATAACATCCAATTCTGAGATGAAACAGTCTAAAATAGGAGTAAAGCATGCACTACTTGTTGAAGTGTGAAATGGAGACTCTG
GACTTTGGGTATTTTTGTAAAACTTTTGATATTTCTGTATACATTTAAAAAATCAATTGCCACTACAGTAGTTCCTTAAGAATAATCTAG
TTATATTTTTTGAAATCACATATAATTAGACTTTATAATATATATACTTTTTCATATATAATTAGATCTTTCTTTGTAATTTCATATGTA
GTTCTTCATAGGGTCTCAGATACAATGGTTTTTATAATTGACATATTGAAAAAGTATATGAACATAATGAAACACCTCATTTATTTGATA
ATTCACTAATGTTTTATATTCATATATTAGGAAAGTGAACTTAGCAAGCTTTTTGGAATTTAAGGATCACATTTAGACATCTCATGGGCT
GATGAATACAGCTGGTATCTTTGTGGAGCTTTCTAATTTACAAAATGCTTTGTAGACCCCATTGTCTTTAAACCATACAACATGCCCGTG
AAGCTGATCTGGTGGGTATGTTTATTCTTGGTTTTCAGTAGGGAAATAGCAGTTCAGAGAGAGGAAGCTCTCTGTCCCAGCACCGAGACT
CACTCCTAAGTCTTCTGATTCCATGAGCAGTCCCCCTTCCCCCATACCCTGCTGTCTCCACGGAGGGAGGTCACAGCCCATCACGCAGGA
CACTGTGATTGTGTTGATGCAGCTGGCTCCACAGCTGTGCATTCCACAGAGATTCAGAAGGCACCTCTTCGGTCAAACATGGCCCCTCTA
TAACCCCACTATTCTTCTCCTATAAACCCTTCCCCCTTCTCTGCACCCAAGCCTTCGCCAAGTAGGCGCACTCTTTGTGATATTGTTTCA

>18039_18039_5_COG6-STXBP4_COG6_chr13_40235018_ENST00000416691_STXBP4_chr17_53108529_ENST00000434978_length(amino acids)=465AA_BP=155
MRMRGRFAHAQYSRCLRGPCLAEVAAGGGTRSAMAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEAL
KALSTFFVENSLRTRRNLRGDIERKSLAINEEFVSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQAD
SKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEAKAVVEETRALRSRIHLAEA
AQRQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPL
SNLSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSE

--------------------------------------------------------------
>18039_18039_6_COG6-STXBP4_COG6_chr13_40235018_ENST00000455146_STXBP4_chr17_53108529_ENST00000299341_length(transcript)=716nt_BP=419nt
GTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGACGCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGA
CCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGG
AGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAA
ATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCA
TAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAA
AGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACT
TGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAG

>18039_18039_6_COG6-STXBP4_COG6_chr13_40235018_ENST00000455146_STXBP4_chr17_53108529_ENST00000299341_length(amino acids)=235AA_BP=135
MAEVAAGGGTRSAMAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRG
DIERKSLAINEEFVSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCL

--------------------------------------------------------------
>18039_18039_7_COG6-STXBP4_COG6_chr13_40235018_ENST00000455146_STXBP4_chr17_53108529_ENST00000376352_length(transcript)=5789nt_BP=419nt
GTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGACGCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGA
CCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGG
AGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAA
ATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCA
TAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAA
AGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACT
TGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAG
AAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAAGAAGTAAATACACTTAAGGAAAAATTATTGGAATCAGATA
AGCAAAGGAAACAATTGACAGAAGAGCTCCAGAATGTGAAACAAGAAGCCAAAGCTGTAGTTGAAGAAACAAGAGCCCTGCGTAGTCGGA
TTCATCTTGCTGAAGCTGCTCAGAGACAGGCACATGGAATGGAAATGGACTATGAAGAAGTGATCCGTCTGTTAGAGGCCAAGATTACAG
AGCTAAAGGCTCAGCTTGCTGATTATTCTGACCAAAATAAAGAAAGTGTTCAGGATTTAAAAAAGAGAATCATGGTACTCGACTGCCAAT
TACGAAAATCAGAAATGGCTCGAAAAACTTTTGAGGCATCCACTGAAAAGCTTCTTCATTTTGTAGAGGCTATTCAAGAAGTATTTTCTG
ATAATTCTACTCCTTTATCAAATTTAAGTGAAAGAAGAGCTGTGTTAGCTTCTCAGACTTCCCTCACACCACTGGGAAGGAATGGACGTA
GCATCCCAGCAACGCTGGCGCTTGAATCTAAGGAACTTGTTAAATCTGTTCGTGCCTTACTTGATATGGATTGTTTACCTTATGGGTGGG
AGGAAGCTTACACAGCAGATGGAATCAAGTACTTCATCAATCATGTAACACAGACTACATCCTGGATCCATCCCGTGATGAGTGTCCTGA
ATCTATCTCGCTCAGAGGAGAATGAAGAGGATTGCTCTAGAGAACTCCCCAACCAGAAAAGTTGATGGTTTTCCTTAGGAAGTGGAGCTA
CATGGATGATGTGAGCAGAGACGCATAACATCCAATTCTGAGATGAAACAGTCTAAAATAGGAGTAAAGCATGCACTACTTGTTGAAGTG
TGAAATGGAGACTCTGGACTTTGGGTATTTTTGTAAAACTTTTGATATTTCTGTATACATTTAAAAAATCAATTGCCACTACAGTAGTTC
CTTAAGAATAATCTAGTTATATTTTTTGAAATCACATATAATTAGACTTTATAATATATATACTTTTTCATATATAATTAGATCTTTCTT
TGTAATTTCATATGTAGTTCTTCATAGGGTCTCAGATACAATGGTTTTTATAATTGACATATTGAAAAAGTATATGAACATAATGAAACA
CCTCATTTATTTGATAATTCACTAATGTTTTATATTCATATATTAGGAAAGTGAACTTAGCAAGCTTTTTGGAATTTAAGGATCACATTT
AGACATCTCATGGGCTGATGAATACAGCTGGTATCTTTGTGGAGCTTTCTAATTTACAAAATGCTTTGTAGACCCCATTGTCTTTAAACC
ATACAACATGCCCGTGAAGCTGATCTGGTGGGTATGTTTATTCTTGGTTTTCAGTAGGGAAATAGCAGTTCAGAGAGAGGAAGCTCTCTG
TCCCAGCACCGAGACTCACTCCTAAGTCTTCTGATTCCATGAGCAGTCCCCCTTCCCCCATACCCTGCTGTCTCCACGGAGGGAGGTCAC
AGCCCATCACGCAGGACACTGTGATTGTGTTGATGCAGCTGGCTCCACAGCTGTGCATTCCACAGAGATTCAGAAGGCACCTCTTCGGTC
AAACATGGCCCCTCTATAACCCCACTATTCTTCTCCTATAAACCCTTCCCCCTTCTCTGCACCCAAGCCTTCGCCAAGTAGGCGCACTCT
TTGTGATATTGTTTCAGCAGACTTCTTTCAGCAGCTCGTGTTTTTCTAAAGTGAAAGGCATGGTTTGTCCTGCTTAGGTTGCCCTTCCCA
GAGGGATGGTTTGAGGGGAGCTGATGAGAAGAGAGGTATCTGTTAAAACATTACTGCTCTACTCGAAACAAGATGGAAGCCTAAAGCCCA
AGTCGAGCAGCTCCCAGCACTGCTGTGCAGACCTAGAGGTCCTTAGAACATAGTCTAAGAACCATTCATTGTAGCCATTTTATAGTTGAG
TAAACTGAGATCTTAAGTCTCCTAGTCTACTGAATTTCATATGGTGTATAATACAGATTTATATGGTAAAGATATACATATACATTGTGC
TCAACTATACATTCCTGAATCCATTTAGGATTTGTGATTTATGTCTTGAGTAATAATATAAAGTCAACTCCAGACTGATAGGTAGTCATT
AGCCATGAGAAATGTTTCAGGATGGCTAGGGAAGACTTGTGTTTTGCCTGACAGCCATTTGAATGTTAGGAAGCTTCGGGGAGACAAGTT
TTGAGAGAAGCCCCAGAGGGAGCTATTTCCTTGCACCCCCCAGAGGTGAATGAGGTATTCTATAAGTTAGTGTCTATAATTGTGAAAGTA
CAAACTTCTTGTTTTTGTCAAATTAATGGTATGAAATTTCTCTCCCCCTGCTTGAAGAGTTTTCTAATTCGTTTCTAGTGAGCAAAACAA
AGAAGGTGCTTGAGTCACTGAAATCAAAGTACTCAGGCACACAGCCCACTGACAAGAGACACCTCATCCATTAACTGCTGTTTTGTACCA
CTTGCCGCCCTGTTTCTGTCAAATACCTAGTGAAAAAGGCCTAAACAATTGTAATGATATTATTTATTGGGCATTTTGTGCCATACATGG
TGATGAGCAGTTTGCATATATTTATTTATGATCTTCTTAAAACCATTCCATGAAATAGGAACTGTAATTATCCCCAATTCTAAAAGAAAA
AACTTAGTTTTAGAGAGTTAGTAATCTTTGCCTAAGGGTCACAAAGCACCTATGTGTAGAAGCTAGGGTTCAAGGCAGATCTGTGATTCC
AGAAGCTGTTCTCTAAACCACTATGGAGAACTGCTTAGATTCATTGTCTATGGGTACATTTTATAAAAAGGCAGATTCTAGTTCAGTGTC
ATAAGGAACTTTCTAGTAATTAGAGCTGATAAGAAAAGAATTCCCCAGGAGAAAATGGAAACACTATCCCAGCAATCTGAATTCCTTACT
TGGGGAATGTTGCTGAGGAGGTTCAGTGTGTGAATGGACTGAACCAGTTGGCCACTCTCTCAGATTCCCTCTTCATAAAGCTTCCGTGAC
TTCTAAACCATCAGGTCGGTGCCATAAGAGATGCTCAAAAAAGCATGGTCAGGGCTTAGCAAGAATCCTTTTCCAGTGCAAATACGACCC
TCATATTATGTTTTGGCGAGTAGCCAGTCTTTCTTTAACATCAATCAACCGTAGCAATGTGGTCATCACGAAGTCTTCATTGACTCACTG
GCTTGGATTTTAGGGTTAGAAAATCTGAATGTTCTTATGTCCTTCCGTCTCACTTTACTAGAGTGCCCAAGTTGACTCATCCTTACTCAC
TCATTCCCTCAAAATATTTATTGAGCACCAACAATGTCACAAGCACTGTGCTAAACACTGTGGTGAAGTAGAACAATTGCTAATCATTTC
CTGGGTTCCACTTACTCTTGATTTAAAAAAAAAAAAACAACAAAAGAGTTTGTGTGTGGCCAGGACTAAACAGCTGCTTCTTAATTTTTG
AATTTTAAAACTAATCTATTTTATTTAAAAAAAATCAAGTACTTTGGAAGTGAATAAAGTAAGAGATAGCCTGTCTCACTTTCCAGAGGT
AGCAGTCACTAATACTGTGGTGAGTGATTTTACTCAAAGGAAATCACACTATTAAGCAGCTTGGTTTTGACATGTTATGTTGTGGTCATC
TTTTCATGTCAATACATAGATTAATCTTTTATTTCAAATGTCTACATAAAATATCACTACCCACATAACCTATAATTTGTGTGGCCAGCA
ATTTATTGAACACTAAAATGTTTTAAGTTTTCTTATTGCTAACAATGTCACAGTGAACATTTATATATTCATTAAATCCTTTTCCTCATG
TATCTTTGCACTCTTGTGCTAGTATGTCTATAGTGTGAATACATTCATAAATTTCTTGATCAAAGCTAGGTCAAAGTTACATTCATTTTA
ATTTTGGTACATATCCATAAATTCTCCATAAAAGTAGGACCAACTTACATTACCACCAATAGTGTATGTGAGCCTTATTTTTATGTATGA
TAGGACTTTTTTTAGTCCAAATGTTCCTATAGATTTTCTGGGTTTTTTTTTTTTTTTTGTCCTTGGAAGAATAACCTTCCTTCCACCAAG
TCCAAGAACCTGAGATTTTTAATCATTAGGTTTTAGATTTCCTTTAGCAGCAGAGACTGACTTGCTGTATAGAGGGAAGTCAAGTAGTGA
CTAACTCACTATATGTCAAACACATCATTACTCTTCTCTTTTCCTACTTTACATGTAATGGTTGCGAGGACCAACTTTCAAATGAGCTAA
CTTGGGTGAGACGTTCACTAAAGTACCAAGCACAATACAAATGCATCTTCGAGTTCTTTGGGCCTCACTTTCCCTATCTGAATAATAAGG
ATAGTAATCCCTTGCCTTTTCTCAAACCAGTTCAACTCAGCAAACACTTCCTGAGCACCTGCTACATGCCAGGCAAAATGTGAAATTTGC
ATGCTATGAGGCTAAATGGTACTGATTCTCAAAACAAGGAGCTCATAGTCTAAAACCATTTTTCTTTCTTTTTTTTCCCCCTAAACAACC
TCTTAAAGGGGTAAGAAGTTAGGGGGTTGTTTATTAAGAACCCCTGAAGAGCAACCCTTTACCACTCTCTTAAATTTGAAAAATTCCAAA
ATAATATTAACACCTCTTGACTAGAAAAGGAAAAAAAAGGAACATGCCGTATGAAGAGCCTCTCCAATAATAAATGCAAAGCAGCTGTCA
AAATATAGAGTCAAGTGATACTTTCATAAAGTGTTTGCACAATTAGAAAATGTTATCCTTTTTCTCGGGAGAAATGGGACATTTTTATTT
TCTCTGCTAAGTGAAATGCAACTTTTTGAAGAATCAACACGCTTGACATTTTTACAATGTACATAAAGAACTGAACTATTATTAAAACAA
CTTACACACTCCATTGCTTATAACTTTTGAGAGAATGAAAAGAACCTTAAACAGAATGTGCCTGTGGAGCTTCGCTTTAGAAATGAAATA
CCCAAGGTGTTTTAACTACAACTGTCTACATGTAATAGTGTGTCTGCATAATGACTTTGTAAATATTAACTGCAATTCTGTATTTGCTTT

>18039_18039_7_COG6-STXBP4_COG6_chr13_40235018_ENST00000455146_STXBP4_chr17_53108529_ENST00000376352_length(amino acids)=467AA_BP=135
MAEVAAGGGTRSAMAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRG
DIERKSLAINEEFVSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCL
QLDEVNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLA
EAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNST
PLSNLSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSR

--------------------------------------------------------------
>18039_18039_8_COG6-STXBP4_COG6_chr13_40235018_ENST00000455146_STXBP4_chr17_53108529_ENST00000398391_length(transcript)=1863nt_BP=419nt
GTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGACGCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGA
CCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGG
AGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAA
ATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCA
TAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAA
AGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACT
TGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAG
AAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAAGAAGTAAATACACTTAAGTGGCCAGGGCAGAATTAGATGA
AGAGCCAATAAAGCAAGTCGTGGCAATTTTGGATCCTGTGAGTTCTTTGGGAAATACATTTTTTTTCATGTGCAGGGCTATTCTTAAGGG
ACATCATGTTTTGCTAACGTAATTTGGAATTAATATTATTTTAGAGAGGAAAAAAACACACATATCCCAAATATACTGTAACATTTTTCT
TCTCTTTTTTTGTTTGTTTGGTTTTTTGATTCTTGTTTTTGTTTTGTGTTTTTGAGACAGGGTCGCACTCTGTCGCCCAGGCTGGAGTGC
AATACTGCAATCACGTCTCACTGCAGCCTCAACCTCCTGGGTTCAAGTGATTCTCCCACCTCAACCTCCCAAGTAACTGGGACAACATGT
CCATGCCACCATGCTCAACTAATTTTTTTTTAAATTTTTATTTTGTAGAGATGGTGTCTCACTATTTTGTTCAGACTGGTCTCAAACACC
TGGGCTCAAATGACCCACCTACCTCAGCCTCTCAAAGTGCTGGGATTACAGGTGTGAGCCACCATGTCTGGCCTTGATTCTCTTTATGTG
GTTTCATTCTGTTTTTAGAAGAATATTACATTTAAATTATATCCTAATTTTTATAGAAAGCTATATTTTCCAAATCTTTAGGAAAAGCAA
CATAACTACTTGATTTACCACTAATTCGTCATAGGCACATATTTTTAAAATTATTTTATTAAATAAGGTATAGTATATTGATAATTATTT
AATTTTTATTAAATAGAAAATATTTACACCAAAAGGAAAGAAAATTTGTTTTGCTACCTTAGTTTTTATAATCTCAACCTCTAGAGGAAG
CCATTGTTGCAAATATATTATTTATCTTTTCATAGATTTTTCTCTACACAGAAAATTATATTTTTTAAAAATAGGCAGGGCATGATGGCT
GACACCTTTAATCGCAGTACTTTGGGAGGCTGAGGCAAGAGGATTACTTGAGCTCAGGAGTTTAACATCAGCCTGGGCAACATAGCAGGA
CCCCATCTCTACTATTTAAAACATAAAAACAAAAATAAATAAATATATGTATATGTGGGGACAGGGAGTATGTGAGAAATTTCTGTACTT

>18039_18039_8_COG6-STXBP4_COG6_chr13_40235018_ENST00000455146_STXBP4_chr17_53108529_ENST00000398391_length(amino acids)=234AA_BP=135
MAEVAAGGGTRSAMAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRG
DIERKSLAINEEFVSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCL

--------------------------------------------------------------
>18039_18039_9_COG6-STXBP4_COG6_chr13_40235018_ENST00000455146_STXBP4_chr17_53108529_ENST00000405898_length(transcript)=1863nt_BP=419nt
GTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGACGCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGA
CCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGG
AGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAA
ATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCA
TAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAA
AGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACT
TGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAG
AAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAAGAAGTAAATACACTTAAGTGGCCAGGGCAGAATTAGATGA
AGAGCCAATAAAGCAAGTCGTGGCAATTTTGGATCCTGTGAGTTCTTTGGGAAATACATTTTTTTTCATGTGCAGGGCTATTCTTAAGGG
ACATCATGTTTTGCTAACGTAATTTGGAATTAATATTATTTTAGAGAGGAAAAAAACACACATATCCCAAATATACTGTAACATTTTTCT
TCTCTTTTTTTGTTTGTTTGGTTTTTTGATTCTTGTTTTTGTTTTGTGTTTTTGAGACAGGGTCGCACTCTGTCGCCCAGGCTGGAGTGC
AATACTGCAATCACGTCTCACTGCAGCCTCAACCTCCTGGGTTCAAGTGATTCTCCCACCTCAACCTCCCAAGTAACTGGGACAACATGT
CCATGCCACCATGCTCAACTAATTTTTTTTTAAATTTTTATTTTGTAGAGATGGTGTCTCACTATTTTGTTCAGACTGGTCTCAAACACC
TGGGCTCAAATGACCCACCTACCTCAGCCTCTCAAAGTGCTGGGATTACAGGTGTGAGCCACCATGTCTGGCCTTGATTCTCTTTATGTG
GTTTCATTCTGTTTTTAGAAGAATATTACATTTAAATTATATCCTAATTTTTATAGAAAGCTATATTTTCCAAATCTTTAGGAAAAGCAA
CATAACTACTTGATTTACCACTAATTCGTCATAGGCACATATTTTTAAAATTATTTTATTAAATAAGGTATAGTATATTGATAATTATTT
AATTTTTATTAAATAGAAAATATTTACACCAAAAGGAAAGAAAATTTGTTTTGCTACCTTAGTTTTTATAATCTCAACCTCTAGAGGAAG
CCATTGTTGCAAATATATTATTTATCTTTTCATAGATTTTTCTCTACACAGAAAATTATATTTTTTAAAAATAGGCAGGGCATGATGGCT
GACACCTTTAATCGCAGTACTTTGGGAGGCTGAGGCAAGAGGATTACTTGAGCTCAGGAGTTTAACATCAGCCTGGGCAACATAGCAGGA
CCCCATCTCTACTATTTAAAACATAAAAACAAAAATAAATAAATATATGTATATGTGGGGACAGGGAGTATGTGAGAAATTTCTGTACTT

>18039_18039_9_COG6-STXBP4_COG6_chr13_40235018_ENST00000455146_STXBP4_chr17_53108529_ENST00000405898_length(amino acids)=234AA_BP=135
MAEVAAGGGTRSAMAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRG
DIERKSLAINEEFVSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCL

--------------------------------------------------------------
>18039_18039_10_COG6-STXBP4_COG6_chr13_40235018_ENST00000455146_STXBP4_chr17_53108529_ENST00000434978_length(transcript)=2364nt_BP=419nt
GTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGACGCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGA
CCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGG
AGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAA
ATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCA
TAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAA
AGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACT
TGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAG
AAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAAGAAGTAAATACACTTAAGGAAGCCAAAGCTGTAGTTGAAG
AAACAAGAGCCCTGCGTAGTCGGATTCATCTTGCTGAAGCTGCTCAGAGACAGGCACATGGAATGGAAATGGACTATGAAGAAGTGATCC
GTCTGTTAGAGGCCAAGATTACAGAGCTAAAGGCTCAGCTTGCTGATTATTCTGACCAAAATAAAGAAAGTGTTCAGGATTTAAAAAAGA
GAATCATGGTACTCGACTGCCAATTACGAAAATCAGAAATGGCTCGAAAAACTTTTGAGGCATCCACTGAAAAGCTTCTTCATTTTGTAG
AGGCTATTCAAGAAGTATTTTCTGATAATTCTACTCCTTTATCAAATTTAAGTGAAAGAAGAGCTGTGTTAGCTTCTCAGACTTCCCTCA
CACCACTGGGAAGGAATGGACGTAGCATCCCAGCAACGCTGGCGCTTGAATCTAAGGAACTTGTTAAATCTGTTCGTGCCTTACTTGATA
TGGATTGTTTACCTTATGGGTGGGAGGAAGCTTACACAGCAGATGGAATCAAGTACTTCATCAATCATGTAACACAGACTACATCCTGGA
TCCATCCCGTGATGAGTGTCCTGAATCTATCTCGCTCAGAGGAGAATGAAGAGGATTGCTCTAGAGAACTCCCCAACCAGAAAAGTTGAT
GGTTTTCCTTAGGAAGTGGAGCTACATGGATGATGTGAGCAGAGACGCATAACATCCAATTCTGAGATGAAACAGTCTAAAATAGGAGTA
AAGCATGCACTACTTGTTGAAGTGTGAAATGGAGACTCTGGACTTTGGGTATTTTTGTAAAACTTTTGATATTTCTGTATACATTTAAAA
AATCAATTGCCACTACAGTAGTTCCTTAAGAATAATCTAGTTATATTTTTTGAAATCACATATAATTAGACTTTATAATATATATACTTT
TTCATATATAATTAGATCTTTCTTTGTAATTTCATATGTAGTTCTTCATAGGGTCTCAGATACAATGGTTTTTATAATTGACATATTGAA
AAAGTATATGAACATAATGAAACACCTCATTTATTTGATAATTCACTAATGTTTTATATTCATATATTAGGAAAGTGAACTTAGCAAGCT
TTTTGGAATTTAAGGATCACATTTAGACATCTCATGGGCTGATGAATACAGCTGGTATCTTTGTGGAGCTTTCTAATTTACAAAATGCTT
TGTAGACCCCATTGTCTTTAAACCATACAACATGCCCGTGAAGCTGATCTGGTGGGTATGTTTATTCTTGGTTTTCAGTAGGGAAATAGC
AGTTCAGAGAGAGGAAGCTCTCTGTCCCAGCACCGAGACTCACTCCTAAGTCTTCTGATTCCATGAGCAGTCCCCCTTCCCCCATACCCT
GCTGTCTCCACGGAGGGAGGTCACAGCCCATCACGCAGGACACTGTGATTGTGTTGATGCAGCTGGCTCCACAGCTGTGCATTCCACAGA
GATTCAGAAGGCACCTCTTCGGTCAAACATGGCCCCTCTATAACCCCACTATTCTTCTCCTATAAACCCTTCCCCCTTCTCTGCACCCAA
GCCTTCGCCAAGTAGGCGCACTCTTTGTGATATTGTTTCAGCAGACTTCTTTCAGCAGCTCGTGTTTTTCTAAAGTGAAAGGCATGGTTT

>18039_18039_10_COG6-STXBP4_COG6_chr13_40235018_ENST00000455146_STXBP4_chr17_53108529_ENST00000434978_length(amino acids)=445AA_BP=135
MAEVAAGGGTRSAMAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRG
DIERKSLAINEEFVSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCL
QLDEVNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLE
AKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for COG6-STXBP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for COG6-STXBP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for COG6-STXBP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCOG6C3553230CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIl6CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneCOG6C3809160Hypohidrosis, enamel hypoplasia, palmoplantar keratoderma, intellectual disability syndrome5GENOMICS_ENGLAND;ORPHANET
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human