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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DOCK6-NFIX (FusionGDB2 ID:HG57572TG4784)

Fusion Gene Summary for DOCK6-NFIX

check button Fusion gene summary
Fusion gene informationFusion gene name: DOCK6-NFIX
Fusion gene ID: hg57572tg4784
HgeneTgene
Gene symbol

DOCK6

NFIX

Gene ID

57572

4784

Gene namededicator of cytokinesis 6nuclear factor I X
SynonymsAOS2|ZIR1CTF|MRSHSS|NF-I/X|NF1-X|NF1A|SOTOS2
Cytomap('DOCK6')('NFIX')

19p13.2

19p13.13

Type of geneprotein-codingprotein-coding
Descriptiondedicator of cytokinesis protein 6nuclear factor 1 X-typeCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/X
Modification date2020031320200329
UniProtAcc.

Q14938

Ensembl transtripts involved in fusion geneENST00000294618, ENST00000319867, 
ENST00000586702, 		ENST00000294618, 
ENST00000319867, ENST00000586702, 
Fusion gene scores* DoF score11 X 12 X 5=66022 X 13 X 10=2860
# samples 1226
** MAII scorelog2(12/660*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/2860*10)=-3.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DOCK6 [Title/Abstract] AND NFIX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDOCK6(11373073)-NFIX(13183861), # samples:3
Anticipated loss of major functional domain due to fusion event.DOCK6-NFIX seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DOCK6-NFIX seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
DOCK6-NFIX seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNFIX

GO:0000122

negative regulation of transcription by RNA polymerase II

19706729

TgeneNFIX

GO:0045944

positive regulation of transcription by RNA polymerase II

19706729



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-2H-A9GG-01ADOCK6chr19

11373073

-NFIXchr19

13183861

+
ChimerDB4ESCATCGA-2H-A9GGDOCK6chr19

11373072

-NFIXchr19

13183860

+
ChimerDB4ESCATCGA-2H-A9GGDOCK6chr19

11373073

-NFIXchr19

13183861

+


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Fusion Gene ORF analysis for DOCK6-NFIX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000294618ENST00000588680DOCK6chr19

11373073

-NFIXchr19

13183861

+
5CDS-3UTRENST00000294618ENST00000588680DOCK6chr19

11373072

-NFIXchr19

13183860

+
Frame-shiftENST00000294618ENST00000358552DOCK6chr19

11373073

-NFIXchr19

13183861

+
Frame-shiftENST00000294618ENST00000358552DOCK6chr19

11373072

-NFIXchr19

13183860

+
Frame-shiftENST00000294618ENST00000360105DOCK6chr19

11373073

-NFIXchr19

13183861

+
Frame-shiftENST00000294618ENST00000360105DOCK6chr19

11373072

-NFIXchr19

13183860

+
Frame-shiftENST00000294618ENST00000397661DOCK6chr19

11373073

-NFIXchr19

13183861

+
Frame-shiftENST00000294618ENST00000397661DOCK6chr19

11373072

-NFIXchr19

13183860

+
Frame-shiftENST00000294618ENST00000585575DOCK6chr19

11373073

-NFIXchr19

13183861

+
Frame-shiftENST00000294618ENST00000585575DOCK6chr19

11373072

-NFIXchr19

13183860

+
Frame-shiftENST00000294618ENST00000587260DOCK6chr19

11373073

-NFIXchr19

13183861

+
Frame-shiftENST00000294618ENST00000587260DOCK6chr19

11373072

-NFIXchr19

13183860

+
Frame-shiftENST00000294618ENST00000587760DOCK6chr19

11373073

-NFIXchr19

13183861

+
Frame-shiftENST00000294618ENST00000587760DOCK6chr19

11373072

-NFIXchr19

13183860

+
Frame-shiftENST00000294618ENST00000588228DOCK6chr19

11373073

-NFIXchr19

13183861

+
Frame-shiftENST00000294618ENST00000588228DOCK6chr19

11373072

-NFIXchr19

13183860

+
Frame-shiftENST00000294618ENST00000592199DOCK6chr19

11373073

-NFIXchr19

13183861

+
Frame-shiftENST00000294618ENST00000592199DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3CDSENST00000319867ENST00000358552DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3CDSENST00000319867ENST00000358552DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3CDSENST00000319867ENST00000360105DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3CDSENST00000319867ENST00000360105DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3CDSENST00000319867ENST00000397661DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3CDSENST00000319867ENST00000397661DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3CDSENST00000319867ENST00000585575DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3CDSENST00000319867ENST00000585575DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3CDSENST00000319867ENST00000587260DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3CDSENST00000319867ENST00000587260DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3CDSENST00000319867ENST00000587760DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3CDSENST00000319867ENST00000587760DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3CDSENST00000319867ENST00000588228DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3CDSENST00000319867ENST00000588228DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3CDSENST00000319867ENST00000592199DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3CDSENST00000319867ENST00000592199DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3CDSENST00000586702ENST00000358552DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3CDSENST00000586702ENST00000358552DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3CDSENST00000586702ENST00000360105DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3CDSENST00000586702ENST00000360105DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3CDSENST00000586702ENST00000397661DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3CDSENST00000586702ENST00000397661DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3CDSENST00000586702ENST00000585575DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3CDSENST00000586702ENST00000585575DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3CDSENST00000586702ENST00000587260DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3CDSENST00000586702ENST00000587260DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3CDSENST00000586702ENST00000587760DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3CDSENST00000586702ENST00000587760DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3CDSENST00000586702ENST00000588228DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3CDSENST00000586702ENST00000588228DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3CDSENST00000586702ENST00000592199DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3CDSENST00000586702ENST00000592199DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3UTRENST00000319867ENST00000588680DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3UTRENST00000319867ENST00000588680DOCK6chr19

11373072

-NFIXchr19

13183860

+
intron-3UTRENST00000586702ENST00000588680DOCK6chr19

11373073

-NFIXchr19

13183861

+
intron-3UTRENST00000586702ENST00000588680DOCK6chr19

11373072

-NFIXchr19

13183860

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DOCK6-NFIX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DOCK6chr1911373072-NFIXchr1913183860+6.29E-070.9999994
DOCK6chr1911373072-NFIXchr1913183860+6.29E-070.9999994
DOCK6chr1911373072-NFIXchr1913183860+6.29E-070.9999994
DOCK6chr1911373072-NFIXchr1913183860+6.29E-070.9999994


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DOCK6-NFIX


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:11373073/:13183861)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NFIX

Q14938

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DOCK6-NFIX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DOCK6-NFIX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DOCK6-NFIX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DOCK6-NFIX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDOCK6C3280182ADAMS-OLIVER SYNDROME 23GENOMICS_ENGLAND
HgeneDOCK6C0265268Adams Oliver syndrome1ORPHANET
TgeneC3553660Malan overgrowth syndrome5GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0265211Marshall-Smith syndrome2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0005586Bipolar Disorder1PSYGENET