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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTMS-BRPF3 (FusionGDB2 ID:HG5763TG27154)

Fusion Gene Summary for PTMS-BRPF3

check button Fusion gene summary
Fusion gene informationFusion gene name: PTMS-BRPF3
Fusion gene ID: hg5763tg27154
HgeneTgene
Gene symbol

PTMS

BRPF3

Gene ID

5763

27154

Gene nameparathymosinbromodomain and PHD finger containing 3
SynonymsParaT-
Cytomap('PTMS')('BRPF3')

12p13.31

6p21.31

Type of geneprotein-codingprotein-coding
Descriptionparathymosinbromodomain and PHD finger-containing protein 3
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000538057, ENST00000309083, 
ENST00000389462, 
Fusion gene scores* DoF score21 X 20 X 10=42004 X 5 X 3=60
# samples 245
** MAII scorelog2(24/4200*10)=-4.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTMS [Title/Abstract] AND BRPF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTMS(6879131)-BRPF3(36169348), # samples:1
Anticipated loss of major functional domain due to fusion event.PTMS-BRPF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTMS-BRPF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTMS-BRPF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTMS-BRPF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTMS-BRPF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PTMS-BRPF3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PTMS-BRPF3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PTMS-BRPF3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBRPF3

GO:0043966

histone H3 acetylation

16387653


check buttonFusion gene breakpoints across PTMS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across BRPF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-19-2619-01APTMSchr12

6879131

+BRPF3chr6

36169348

+


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Fusion Gene ORF analysis for PTMS-BRPF3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000538057ENST00000339717PTMSchr12

6879131

+BRPF3chr6

36169348

+
3UTR-3CDSENST00000538057ENST00000357641PTMSchr12

6879131

+BRPF3chr6

36169348

+
3UTR-3CDSENST00000538057ENST00000443324PTMSchr12

6879131

+BRPF3chr6

36169348

+
3UTR-3CDSENST00000538057ENST00000534400PTMSchr12

6879131

+BRPF3chr6

36169348

+
3UTR-3CDSENST00000538057ENST00000534694PTMSchr12

6879131

+BRPF3chr6

36169348

+
3UTR-3CDSENST00000538057ENST00000543502PTMSchr12

6879131

+BRPF3chr6

36169348

+
Frame-shiftENST00000309083ENST00000443324PTMSchr12

6879131

+BRPF3chr6

36169348

+
Frame-shiftENST00000309083ENST00000543502PTMSchr12

6879131

+BRPF3chr6

36169348

+
Frame-shiftENST00000389462ENST00000339717PTMSchr12

6879131

+BRPF3chr6

36169348

+
Frame-shiftENST00000389462ENST00000357641PTMSchr12

6879131

+BRPF3chr6

36169348

+
Frame-shiftENST00000389462ENST00000443324PTMSchr12

6879131

+BRPF3chr6

36169348

+
Frame-shiftENST00000389462ENST00000534400PTMSchr12

6879131

+BRPF3chr6

36169348

+
Frame-shiftENST00000389462ENST00000534694PTMSchr12

6879131

+BRPF3chr6

36169348

+
Frame-shiftENST00000389462ENST00000543502PTMSchr12

6879131

+BRPF3chr6

36169348

+
In-frameENST00000309083ENST00000339717PTMSchr12

6879131

+BRPF3chr6

36169348

+
In-frameENST00000309083ENST00000357641PTMSchr12

6879131

+BRPF3chr6

36169348

+
In-frameENST00000309083ENST00000534400PTMSchr12

6879131

+BRPF3chr6

36169348

+
In-frameENST00000309083ENST00000534694PTMSchr12

6879131

+BRPF3chr6

36169348

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000309083PTMSchr126879131+ENST00000357641BRPF3chr636169348+50304801102848912
ENST00000309083PTMSchr126879131+ENST00000339717BRPF3chr636169348+40204801102038642
ENST00000309083PTMSchr126879131+ENST00000534694BRPF3chr636169348+38284801101846578
ENST00000309083PTMSchr126879131+ENST00000534400BRPF3chr636169348+34594801102551813

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000309083ENST00000357641PTMSchr126879131+BRPF3chr636169348+0.0013042180.9986958
ENST00000309083ENST00000339717PTMSchr126879131+BRPF3chr636169348+0.0015374280.99846256
ENST00000309083ENST00000534694PTMSchr126879131+BRPF3chr636169348+0.001131230.99886876
ENST00000309083ENST00000534400PTMSchr126879131+BRPF3chr636169348+0.008664080.99133587

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Fusion Genomic Features for PTMS-BRPF3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for PTMS-BRPF3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:6879131/chr6:36169348)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBRPF3chr12:6879131chr6:36169348ENST00000357641013406_43201206.0Compositional biasNote=Glu-rich
TgeneBRPF3chr12:6879131chr6:36169348ENST000003576410131076_115901206.0DomainPWWP
TgeneBRPF3chr12:6879131chr6:36169348ENST00000357641013606_67601206.0DomainBromo
TgeneBRPF3chr12:6879131chr6:36169348ENST00000357641013212_26201206.0Zinc fingerPHD-type 1
TgeneBRPF3chr12:6879131chr6:36169348ENST00000357641013266_29901206.0Zinc fingerC2HC pre-PHD-type
TgeneBRPF3chr12:6879131chr6:36169348ENST00000357641013323_38701206.0Zinc fingerPHD-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTMSchr12:6879131chr6:36169348ENST00000309083+1536_900103.0Compositional biasNote=Asp/Glu-rich (acidic)


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Fusion Gene Sequence for PTMS-BRPF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70114_70114_1_PTMS-BRPF3_PTMS_chr12_6879131_ENST00000309083_BRPF3_chr6_36169348_ENST00000339717_length(transcript)=4020nt_BP=480nt
GGCAGCTCTGCTGGTGCGGGGGCGGCGAGCCCGGGATCGAGCTACCGCGGCCGAGCGCGCCGGCCACCGCCTGCACCGCCCTTCCGCCCG
CCCTCCGGACGGCCGCAGCCCTGCGGGTCTCCGCTCCAGACCCACCCCCGCCCCACCCCGCGCGCCTCTGCCGCCTCTTCCAGAGACCCA
GCTTGCCGAGCGGCCGCCGCTGCCGCTGTCGCCGCCGCCGCCGCCACCGCGCCAGGTTCCGGCCGCGGCCACCCTCCGCCGTCCAGGGCC
CCTCCGTCTCGGCCCCGGGACCCCGGCTCCCCGCCAGCCCCGGCCCCGGCCCCGGCACCATGTCGGAGAAAAGCGTGGAGGCAGCGGCCG
AGTTGAGCGCCAAGGACCTGAAGGAGAAGAAGGAGAAGGTGGAGGAGAAGGCAAGCCGGAAAGAGCGAAAGAAAGAAGTGGTGGAGGATG
GAGAGGAGGAAGATGAAGGGGAAGAAGAAGATGGAGAGGAGGAAGAAGAGGAAGAGGTGGAGGAAGAAGAGCAGGAAGCTCAAGGCGGGG
TGAGTGGCTCCCTCAAGGGAGTGCCCAAGAAAAGCAAGATGAGTTTGAAGCAGAAGATCAAGAAGGAGCCAGAGGAAGCAGGCCAAGACA
CACCCTCCACTCTCCCCATGCTTGCTGTCCCACAGATACCCTCTTACAGGTTGAACAAGATCTGTAGTGGTCTCTCCTTTCAGAGGAAAA
ACCAGTTTATGCAGCGGCTTCACAATTATTGGCTGTTGAAGCGGCAGGCACGGAATGGTGTCCCTCTTATCCGGCGCTTGCACTCCCATC
TGCAGTCCCAAAGAAACGCTGAGCAGCGAGAGCAGGATGAGAAGACAAGTGCAGTGAAGGAGGAGCTGAAGTATTGGCAGAAGCTCCGGC
ATGACTTGGAGCGGGCGCGGCTGCTGATTGAGCTGATTCGGAAGAGAGAGAAGCTCAAACGAGAGCAGGTCAAAGTCCAGCAGGCTGCCA
TGGAGCTGGAGCTGATGCCATTCAATGTTCTGTTGAGGACAACACTGGACCTGCTGCAGGAGAAGGATCCTGCACACATCTTCGCAGAAC
CAGTCAACTTGAGTGAGGTTCCAGATTACCTGGAATTCATATCCAAGCCAATGGATTTTTCTACTATGAGGCGGAAGCTGGAGTCCCACC
TGTACCGCACCTTGGAGGAGTTTGAGGAGGACTTTAACCTTATAGTTACCAACTGCATGAAGTATAATGCTAAAGACACAATTTTCCACC
GAGCAGCTGTCCGCCTGCGGGACCTGGGAGGGGCCATCCTACGGCACGCCCGGCGGCAGGCAGAGAACATCGGCTATGACCCCGAGAGGG
GCACTCACCTGCCCGAGTCACCCAAATTGGAAGACTTTTACCGCTTCTCCTGGGAAGACGGCATGACCAACGGCTTTGGAAAACACACCG
AAAGCGGGTCTGACTCTGAATGTAGTTTGGGTCTCAGTGGTGGACTGGCATTTGAAGCTTGCAGTGGTCTGACGCCCCCCAAACGCAGCC
GTGGGAAGCCAGCCCTGTCTCGAGTGCCCTTCCTGGAAGGTGTGAACGGAGACTCTGACTACAATGGCTCAGGCAGAAGCCTCCTGCTGC
CCTTTGAAGACCGCGGAGACCTGGAGCCCTTGGAGCTGGTGTGGGCCAAGTGCCGAGGCTACCCCTCCTACCCTGCCTTGATCATCGATC
CCAAGATGCCCCGGGAGGGCCTCCTGCACAATGGCGTTCCCATCCCTGTCCCCCCGCTGGACGTGCTGAAGCTGGGAGAGCAGAAACAGG
CAGAGGCTGGAGAGAAGCTCTTCCTTGTCCTCTTCTTTGACAACAAGCGCACCTGGCAGTGGCTTCCAAGGGACAAAGTCCTGCCCTTGG
GTGTGGAAGACACCGTGGACAAGCTCAAGATGCTGGAAGGCCGCAAGACCAGCATCCGCAAGTCAGTGCAGGTGGCCTATGACCGTGCGA
TGATCCACCTGAGCAGAGTCCGGGGGCCCCACTCCTTCGTCACTTCCAGCTACCTGTAAGGGCAGGGCTGGGCCTGCATCCGCTTGCCCT
GCCTCCATCCCGCAGGGCACAGAGAAGCCTCTTCTGCCCCTGCCAGATGTATGGCCGGCAGCTTCCCCCTCTCATGGTAGGCCAGGGACT
GGGCTTTCTCCCCACTAAGGGCAAGGCCCCAGTTTTGACCAATCGCATGGTTCTCCTGGCAGGCCTGCTGTGTGCCAAAAACTCCCACCC
AAGGTCCCTCAGGGGATATTTCACTGAAGAACCAGTTAGAAGTAGAAACAGCTGTGGGGCTTGGGCCCAGCTTAGGAGATTGCCCAGATG
GCAAGAGGTCCTGGGCTCCTTCTTGAGGGGCTGCCTGGCCCGCTCCATCCTACTCCCACTAACTACACCTCAGGGCGGGTGAGGTTCCGA
CACTGATCCCAGAGATGCCGTGGATACGCCAGGGTCCCAGGGGGAATCTCCCCAAGCTCACACTCTCTCCCGCTTATCGCCTATTCTCAC
ACCTCTTCTCGGTCCCATCTTCTGCACCCATTGCCCAGTCTTGCTTTCTCTTTCCCATATTCCTTTTCTTTTTCTCTTGTGCCAAACTGA
CAGAAACCGTCACCACACTGGTCTTTTTCTTTAATGTCTCATTCCCCTTGAGGCCAGCTGCTATGCCAGGTGGTGTCTCTGCCAGGCTCC
TCAGGCCCAGACAGAGGCCAGCCCACAACCTATGACCCCCTCCCCCAGGACACCACCTCCCACCCACAGACCTTCCCTTTAGCTGTTGAC
ACAACTTCCCAGCTCTGCAAGTGTGCCCCCTGGATCAAGGCGGGTCCCCTCTTGTTTTTTTCTTTGCTGCCACGAGGTGGTCCAAGCCTT
CAGGGTGGGCTCCTATCAGGCTGGGTGTGCGAGTGTCCATCTGTCCACATGGATGTCGAGGGTGGTTTGTGTGGAGCTGTGCTCGTCAGC
TGGGTCTGCCCTCTTCCCCCTTTTCTCCTTCTTCTCTCCTCATGGACTTTTTCTGCAATTGCAGTCTTAAGCTTCACTCTCCACCACCTG
GATGGCATGGCGCCTGCCACCAAACATCTTCCTGGCCTGCGCTCTGCCCTGCCCTGCCTAGCCTCTGCTACTCCCACTTCCCAACTCCAG
GGAATGCATTACTTTTATTTCAAACCCTCTGCCTCCTTCCTTCTTTCTCTTCAACCCCCTCCCCACCTTCACCTTCTCAAAAATGGAAGG
AAAAAAAAACTGTGAATGGGGAATGCTGACTGACAAACCAACACAACTTTCAGAGGCTTCAGTGTCTGTTCTCTGGACATTTCTTTTCAC
CTCCTGAGCACCAAAGTCGCAGGGCCAGTTGCAGGCCGCTGATTGCCATGTTGATTTTTAACCTGATATTCTTTTTAATTGTTTTAAATT
TTTCATAGGGGAGTTTTGGACAAAACAGTCACTGGGGAGATCACTGCCATTTTTACACACTTGACTTTTTAAAAATACAACCAACCAACC
ACCACAACTTCTTATACATTTGGGACATGAGCCAGAGTTTAAAAGGGAACCAACAAAACACTATAACTTAAAAGGATGGGGTTTTGGATT
TTGTATAATAATAAAAACAATACAGCATATGGCTAGGGAAGGACATGGTGTATATAATTGTAAAATACTGTTCTAAATTATTCAGGCCTA
TAGTTTCCATTACTGGAGTCCTCCATTGTGTGGCCACACAGTGTCGTTGATTTAAAGGAGCCAGTGCTTCCCCTCTCCCCAGGTAGTTGG
TCAGCTGTGGACTCTGTGACCTTTGTCTAAACCTGTGTTGTAAGATCTTGGGACTTCCTCTCTTTCTATGTCTATCTCTTCCCCCCAACA
CTTTCTCTTCTTAGTCTCTCTCTTTATTTTTCAATCTCTGAATATTTTAGTCTCTCTCTGAGTCTCATTTTTTAAAATGCTCTTTTAGAA

>70114_70114_1_PTMS-BRPF3_PTMS_chr12_6879131_ENST00000309083_BRPF3_chr6_36169348_ENST00000339717_length(amino acids)=642AA_BP=121
MRVSAPDPPPPHPARLCRLFQRPSLPSGRRCRCRRRRRHRARFRPRPPSAVQGPSVSAPGPRLPASPGPGPGTMSEKSVEAAAELSAKDL
KEKKEKVEEKASRKERKKEVVEDGEEEDEGEEEDGEEEEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPM
LAVPQIPSYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERAR
LLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEE
FEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFSWEDGMTNGFGKHTESGSDSE
CSLGLSGGLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLEPLELVWAKCRGYPSYPALIIDPKMPREG
LLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRV

--------------------------------------------------------------
>70114_70114_2_PTMS-BRPF3_PTMS_chr12_6879131_ENST00000309083_BRPF3_chr6_36169348_ENST00000357641_length(transcript)=5030nt_BP=480nt
GGCAGCTCTGCTGGTGCGGGGGCGGCGAGCCCGGGATCGAGCTACCGCGGCCGAGCGCGCCGGCCACCGCCTGCACCGCCCTTCCGCCCG
CCCTCCGGACGGCCGCAGCCCTGCGGGTCTCCGCTCCAGACCCACCCCCGCCCCACCCCGCGCGCCTCTGCCGCCTCTTCCAGAGACCCA
GCTTGCCGAGCGGCCGCCGCTGCCGCTGTCGCCGCCGCCGCCGCCACCGCGCCAGGTTCCGGCCGCGGCCACCCTCCGCCGTCCAGGGCC
CCTCCGTCTCGGCCCCGGGACCCCGGCTCCCCGCCAGCCCCGGCCCCGGCCCCGGCACCATGTCGGAGAAAAGCGTGGAGGCAGCGGCCG
AGTTGAGCGCCAAGGACCTGAAGGAGAAGAAGGAGAAGGTGGAGGAGAAGGCAAGCCGGAAAGAGCGAAAGAAAGAAGTGGTGGAGGATG
GAGAGGAGGAAGATGAAGGGGAAGAAGAAGATGGAGAGGAGGAAGAAGAGGAAGAGGTGGAGGAAGAAGAGCAGGAAGCTCAAGGCGGGG
TGAGTGGCTCCCTCAAGGGAGTGCCCAAGAAAAGCAAGATGAGTTTGAAGCAGAAGATCAAGAAGGAGCCAGAGGAAGCAGGCCAAGACA
CACCCTCCACTCTCCCCATGCTTGCTGTCCCACAGATACCCTCTTACAGGTTGAACAAGATCTGTAGTGGTCTCTCCTTTCAGAGGAAAA
ACCAGTTTATGCAGCGGCTTCACAATTATTGGCTGTTGAAGCGGCAGGCACGGAATGGTGTCCCTCTTATCCGGCGCTTGCACTCCCATC
TGCAGTCCCAAAGAAACGCTGAGCAGCGAGAGCAGGATGAGAAGACAAGTGCAGTGAAGGAGGAGCTGAAGTATTGGCAGAAGCTCCGGC
ATGACTTGGAGCGGGCGCGGCTGCTGATTGAGCTGATTCGGAAGAGAGAGAAGCTCAAACGAGAGCAGGTCAAAGTCCAGCAGGCTGCCA
TGGAGCTGGAGCTGATGCCATTCAATGTTCTGTTGAGGACAACACTGGACCTGCTGCAGGAGAAGGATCCTGCACACATCTTCGCAGAAC
CAGTCAACTTGAGTGAGGTTCCAGATTACCTGGAATTCATATCCAAGCCAATGGATTTTTCTACTATGAGGCGGAAGCTGGAGTCCCACC
TGTACCGCACCTTGGAGGAGTTTGAGGAGGACTTTAACCTTATAGTTACCAACTGCATGAAGTATAATGCTAAAGACACAATTTTCCACC
GAGCAGCTGTCCGCCTGCGGGACCTGGGAGGGGCCATCCTACGGCACGCCCGGCGGCAGGCAGAGAACATCGGCTATGACCCCGAGAGGG
GCACTCACCTGCCCGAGTCACCCAAATTGGAAGACTTTTACCGCTTCTCCTGGGAAGACGTGGACAACATCCTCATCCCAGAGAACCGGG
CCCATTTGTCCCCAGAGGTGCAGCTGAAGGAGCTGCTGGAGAAACTGGACCTGGTGAGCGCCATGCGGTCCAGTGGGGCCCGCACCCGTC
GTGTCCGCCTGCTACGCCGGGAGATCAATGCCCTTCGGCAGAAGCTGGCACAGCCACCACCACCACAGCCACCATCACTCAACAAGACAG
TATCCAATGGGGAGCTGCCAGCAGGGCCCCAGGGGGATGCAGCTGTGCTGGAGCAGGCCTTGCAGGAGGAGCCAGAAGACGATGGGGACA
GAGATGACTCCAAACTGCCTCCTCCGCCAACCCTGGAGCCCACTGGGCCTGCACCTTCCTTGTCTGAGCAAGAATCCCCCCCGGAGCCCC
CTACTCTGAAACCCATTAATGATAGCAAACCTCCAAGCAGGTTCCTAAAGCCCAGAAAGGTGGAAGAAGATGAGCTCTTGGAAAAATCAC
CACTGCAGCTAGGGAATGAGCCTTTGCAACGCTTGCTCAGTGACAATGGCATCAACAGACTATCCCTCATGGCCCCTGACACCCCGGCCG
GTACCCCACTTAGTGGTGTGGGTCGCCGCACATCAGTCCTCTTCAAGAAGGCCAAGAATGGGGTTAAGCTACAGAGAAGCCCAGACAGGG
TCCTGGAGAATGGCGAGGACCATGGTGTGGCAGGCTCTCCTGCCTCTCCAGCCAGCATCGAGGAAGAGCGCCACTCCCGGAAGCGGCCAA
GGAGCAGGAGCTGTAGTGAGAGCGAAGGGGAGAGGTCCCCCCAGCAGGAGGAAGAGACAGGCATGACCAACGGCTTTGGAAAACACACCG
AAAGCGGGTCTGACTCTGAATGTAGTTTGGGTCTCAGTGGTGGACTGGCATTTGAAGCTTGCAGTGGTCTGACGCCCCCCAAACGCAGCC
GTGGGAAGCCAGCCCTGTCTCGAGTGCCCTTCCTGGAAGGTGTGAACGGAGACTCTGACTACAATGGCTCAGGCAGAAGCCTCCTGCTGC
CCTTTGAAGACCGCGGAGACCTGGAGCCCTTGGAGCTGGTGTGGGCCAAGTGCCGAGGCTACCCCTCCTACCCTGCCTTGATCATCGATC
CCAAGATGCCCCGGGAGGGCCTCCTGCACAATGGCGTTCCCATCCCTGTCCCCCCGCTGGACGTGCTGAAGCTGGGAGAGCAGAAACAGG
CAGAGGCTGGAGAGAAGCTCTTCCTTGTCCTCTTCTTTGACAACAAGCGCACCTGGCAGTGGCTTCCAAGGGACAAAGTCCTGCCCTTGG
GTGTGGAAGACACCGTGGACAAGCTCAAGATGCTGGAAGGCCGCAAGACCAGCATCCGCAAGTCAGTGCAGGTGGCCTATGACCGTGCGA
TGATCCACCTGAGCAGAGTCCGGGGGCCCCACTCCTTCGTCACTTCCAGCTACCTGTAAGGGCAGGGCTGGGCCTGCATCCGCTTGCCCT
GCCTCCATCCCGCAGGGCACAGAGAAGCCTCTTCTGCCCCTGCCAGATGTATGGCCGGCAGCTTCCCCCTCTCATGGTAGGCCAGGGACT
GGGCTTTCTCCCCACTAAGGGCAAGGCCCCAGTTTTGACCAATCGCATGGTTCTCCTGGCAGGCCTGCTGTGTGCCAAAAACTCCCACCC
AAGGTCCCTCAGGGGATATTTCACTGAAGAACCAGTTAGAAGTAGAAACAGCTGTGGGGCTTGGGCCCAGCTTAGGAGATTGCCCAGATG
GCAAGAGGTCCTGGGCTCCTTCTTGAGGGGCTGCCTGGCCCGCTCCATCCTACTCCCACTAACTACACCTCAGGGCGGGTGAGGTTCCGA
CACTGATCCCAGAGATGCCGTGGATACGCCAGGGTCCCAGGGGGAATCTCCCCAAGCTCACACTCTCTCCCGCTTATCGCCTATTCTCAC
ACCTCTTCTCGGTCCCATCTTCTGCACCCATTGCCCAGTCTTGCTTTCTCTTTCCCATATTCCTTTTCTTTTTCTCTTGTGCCAAACTGA
CAGAAACCGTCACCACACTGGTCTTTTTCTTTAATGTCTCATTCCCCTTGAGGCCAGCTGCTATGCCAGGTGGTGTCTCTGCCAGGCTCC
TCAGGCCCAGACAGAGGCCAGCCCACAACCTATGACCCCCTCCCCCAGGACACCACCTCCCACCCACAGACCTTCCCTTTAGCTGTTGAC
ACAACTTCCCAGCTCTGCAAGTGTGCCCCCTGGATCAAGGCGGGTCCCCTCTTGTTTTTTTCTTTGCTGCCACGAGGTGGTCCAAGCCTT
CAGGGTGGGCTCCTATCAGGCTGGGTGTGCGAGTGTCCATCTGTCCACATGGATGTCGAGGGTGGTTTGTGTGGAGCTGTGCTCGTCAGC
TGGGTCTGCCCTCTTCCCCCTTTTCTCCTTCTTCTCTCCTCATGGACTTTTTCTGCAATTGCAGTCTTAAGCTTCACTCTCCACCACCTG
GATGGCATGGCGCCTGCCACCAAACATCTTCCTGGCCTGCGCTCTGCCCTGCCCTGCCTAGCCTCTGCTACTCCCACTTCCCAACTCCAG
GGAATGCATTACTTTTATTTCAAACCCTCTGCCTCCTTCCTTCTTTCTCTTCAACCCCCTCCCCACCTTCACCTTCTCAAAAATGGAAGG
AAAAAAAAACTGTGAATGGGGAATGCTGACTGACAAACCAACACAACTTTCAGAGGCTTCAGTGTCTGTTCTCTGGACATTTCTTTTCAC
CTCCTGAGCACCAAAGTCGCAGGGCCAGTTGCAGGCCGCTGATTGCCATGTTGATTTTTAACCTGATATTCTTTTTAATTGTTTTAAATT
TTTCATAGGGGAGTTTTGGACAAAACAGTCACTGGGGAGATCACTGCCATTTTTACACACTTGACTTTTTAAAAATACAACCAACCAACC
ACCACAACTTCTTATACATTTGGGACATGAGCCAGAGTTTAAAAGGGAACCAACAAAACACTATAACTTAAAAGGATGGGGTTTTGGATT
TTGTATAATAATAAAAACAATACAGCATATGGCTAGGGAAGGACATGGTGTATATAATTGTAAAATACTGTTCTAAATTATTCAGGCCTA
TAGTTTCCATTACTGGAGTCCTCCATTGTGTGGCCACACAGTGTCGTTGATTTAAAGGAGCCAGTGCTTCCCCTCTCCCCAGGTAGTTGG
TCAGCTGTGGACTCTGTGACCTTTGTCTAAACCTGTGTTGTAAGATCTTGGGACTTCCTCTCTTTCTATGTCTATCTCTTCCCCCCAACA
CTTTCTCTTCTTAGTCTCTCTCTTTATTTTTCAATCTCTGAATATTTTAGTCTCTCTCTGAGTCTCATTTTTTAAAATGCTCTTTTAGAA
CGGGAAACGGCTCAGATCCTGCTGTGGCACGGGGCCTATGTGTCTCTGTCGCGTCTGCTGTGAAGCACATGATGCTCTATTTATTGTAGA
GAGTGACTTTATTTGCTTTCTAGAATTGTTTATAACAGATGGTATAAGAGAGGTAATAAACAGAGAAAAATCTATGCTTGTAAAGAATAC

>70114_70114_2_PTMS-BRPF3_PTMS_chr12_6879131_ENST00000309083_BRPF3_chr6_36169348_ENST00000357641_length(amino acids)=912AA_BP=121
MRVSAPDPPPPHPARLCRLFQRPSLPSGRRCRCRRRRRHRARFRPRPPSAVQGPSVSAPGPRLPASPGPGPGTMSEKSVEAAAELSAKDL
KEKKEKVEEKASRKERKKEVVEDGEEEDEGEEEDGEEEEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPM
LAVPQIPSYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERAR
LLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEE
FEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFSWEDVDNILIPENRAHLSPEV
QLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQKLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLP
PPPTLEPTGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLSDNGINRLSLMAPDTPAGTPLSGV
GRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSPASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSE
CSLGLSGGLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLEPLELVWAKCRGYPSYPALIIDPKMPREG
LLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRV

--------------------------------------------------------------
>70114_70114_3_PTMS-BRPF3_PTMS_chr12_6879131_ENST00000309083_BRPF3_chr6_36169348_ENST00000534400_length(transcript)=3459nt_BP=480nt
GGCAGCTCTGCTGGTGCGGGGGCGGCGAGCCCGGGATCGAGCTACCGCGGCCGAGCGCGCCGGCCACCGCCTGCACCGCCCTTCCGCCCG
CCCTCCGGACGGCCGCAGCCCTGCGGGTCTCCGCTCCAGACCCACCCCCGCCCCACCCCGCGCGCCTCTGCCGCCTCTTCCAGAGACCCA
GCTTGCCGAGCGGCCGCCGCTGCCGCTGTCGCCGCCGCCGCCGCCACCGCGCCAGGTTCCGGCCGCGGCCACCCTCCGCCGTCCAGGGCC
CCTCCGTCTCGGCCCCGGGACCCCGGCTCCCCGCCAGCCCCGGCCCCGGCCCCGGCACCATGTCGGAGAAAAGCGTGGAGGCAGCGGCCG
AGTTGAGCGCCAAGGACCTGAAGGAGAAGAAGGAGAAGGTGGAGGAGAAGGCAAGCCGGAAAGAGCGAAAGAAAGAAGTGGTGGAGGATG
GAGAGGAGGAAGATGAAGGGGAAGAAGAAGATGGAGAGGAGGAAGAAGAGGAAGAGGTGGAGGAAGAAGAGCAGGAAGCTCAAGGCGGGG
TGAGTGGCTCCCTCAAGGGAGTGCCCAAGAAAAGCAAGATGAGTTTGAAGCAGAAGATCAAGAAGGAGCCAGAGGAAGCAGGCCAAGACA
CACCCTCCACTCTCCCCATGCTTGCTGTCCCACAGATACCCTCTTACAGGTTGAACAAGATCTGTAGTGGTCTCTCCTTTCAGAGGAAAA
ACCAGTTTATGCAGCGGCTTCACAATTATTGGCTGTTGAAGCGGCAGGCACGGAATGGTGTCCCTCTTATCCGGCGCTTGCACTCCCATC
TGCAGTCCCAAAGAAACGCTGAGCAGCGAGAGCAGGATGAGAAGACAAGTGCAGTGAAGGAGGAGCTGAAGTATTGGCAGAAGCTCCGGC
ATGACTTGGAGCGGGCGCGGCTGCTGATTGAGCTGATTCGGAAGAGAGAGAAGCTCAAACGAGAGCAGGTCAAAGTCCAGCAGGCTGCCA
TGGAGCTGGAGCTGATGCCATTCAATGTTCTGTTGAGGACAACACTGGACCTGCTGCAGGAGAAGGATCCTGCACACATCTTCGCAGAAC
CAGTCAACTTGAGTGAGGTTCCAGATTACCTGGAATTCATATCCAAGCCAATGGATTTTTCTACTATGAGGCGGAAGCTGGAGTCCCACC
TGTACCGCACCTTGGAGGAGTTTGAGGAGGACTTTAACCTTATAGTTACCAACTGCATGAAGTATAATGCTAAAGACACAATTTTCCACC
GAGCAGCTGTCCGCCTGCGGGACCTGGGAGGGGCCATCCTACGGCACGCCCGGCGGCAGGCAGAGAACATCGGCTATGACCCCGAGAGGG
GCACTCACCTGCCCGAGTCACCCAAATTGGAAGACTTTTACCGCTTCTCCTGGGAAGACGTGGACAACATCCTCATCCCAGAGAACCGGG
CCCATTTGTCCCCAGAGGTGCAGCTGAAGGAGCTGCTGGAGAAACTGGACCTGGTGAGCGCCATGCGGTCCAGTGGGGCCCGCACCCGTC
GTGTCCGCCTGCTACGCCGGGAGATCAATGCCCTTCGGCAGAAGCTGGCACAGCCACCACCACCACAGCCACCATCACTCAACAAGACAG
TATCCAATGGGGAGCTGCCAGCAGGGCCCCAGGGGGATGCAGCTGTGCTGGAGCAGGCCTTGCAGGAGGAGCCAGAAGACGATGGGGACA
GAGATGACTCCAAACTGCCTCCTCCGCCAACCCTGGAGCCCACTGGGCCTGCACCTTCCTTGTCTGAGCAAGAATCCCCCCCGGAGCCCC
CTACTCTGAAACCCATTAATGATAGCAAACCTCCAAGCAGGTTCCTAAAGCCCAGAAAGGTGGAAGAAGATGAGCTCTTGGAAAAATCAC
CACTGCAGCTAGGGAATGAGCCTTTGCAACGCTTGCTCAGTGACAATGGCATCAACAGACTATCCCTCATGGCCCCTGACACCCCGGCCG
GTACCCCACTTAGTGGTGTGGGTCGCCGCACATCAGTCCTCTTCAAGAAGGCCAAGAATGGGGTTAAGCTACAGAGAAGCCCAGACAGGG
TCCTGGAGAATGGCGAGGACCATGGTGTGGCAGGCTCTCCTGCCTCTCCAGCCAGCATCGAGGAAGAGCGCCACTCCCGGAAGCGGCCAA
GGAGCAGGAGCTGTAGTGAGAGCGAAGGGGAGAGGTCCCCCCAGCAGGAGGAAGAGACAGGCATGACCAACGGCTTTGGAAAACACACCG
AAAGCGGGTCTGACTCTGAATGTAGTTTGGGTCTCAGTGGTGGACTGGCATTTGAAGCTTGCAGTGGTCTGACGCCCCCCAAACGCAGCC
GTGGGAAGCCAGCCCTGTCTCGAGTGCCCTTCCTGGAAGGTGTGAACGGAGACTCTGACTACAATGGCTCAGATCATCGATCCCAAGATG
CCCCGGGAGGGCCTCCTGCACAATGGCGTTCCCATCCCTGTCCCCCCGCTGGACGTGCTGAAGCTGGGAGAGCAGAAACAGGCAGAGGCT
GGAGAGAAGCTCTTCCTTGTCCTCTTCTTTGACAACAAGCGCACCTGGCAGTGGCTTCCAAGGGACAAAGTCCTGCCCTTGGGTGTGGAA
GACACCGTGGACAAGCTCAAGATGCTGGAAGGCCGCAAGACCAGCATCCGCAAGTCAGTGCAGGTGGCCTATGACCGTGCGATGATCCAC
CTGAGCAGAGTCCGGGGGCCCCACTCCTTCGTCACTTCCAGCTACCTGTAAGGGCAGGGCTGGGCCTGCATCCGCTTGCCCTGCCTCCAT
CCCGCAGGGCACAGAGAAGCCTCTTCTGCCCCTGCCAGATGTATGGCCGGCAGCTTCCCCCTCTCATGGTAGGCCAGGGACTGGGCTTTC
TCCCCACTAAGGGCAAGGCCCCAGTTTTGACCAATCGCATGGTTCTCCTGGCAGGCCTGCTGTGTGCCAAAAACTCCCACCCAAGGTCCC
TCAGGGGATATTTCACTGAAGAACCAGTTAGAAGTAGAAACAGCTGTGGGGCTTGGGCCCAGCTTAGGAGATTGCCCAGATGGCAAGAGG
TCCTGGGCTCCTTCTTGAGGGGCTGCCTGGCCCGCTCCATCCTACTCCCACTAACTACACCTCAGGGCGGGTGAGGTTCCGACACTGATC
CCAGAGATGCCGTGGATACGCCAGGGTCCCAGGGGGAATCTCCCCAAGCTCACACTCTCTCCCGCTTATCGCCTATTCTCACACCTCTTC
TCGGTCCCATCTTCTGCACCCATTGCCCAGTCTTGCTTTCTCTTTCCCATATTCCTTTTCTTTTTCTCTTGTGCCAAACTGACAGAAACC
GTCACCACACTGGTCTTTTTCTTTAATGTCTCATTCCCCTTGAGGCCAGCTGCTATGCCAGGTGGTGTCTCTGCCAGGCTCCTCAGGCCC

>70114_70114_3_PTMS-BRPF3_PTMS_chr12_6879131_ENST00000309083_BRPF3_chr6_36169348_ENST00000534400_length(amino acids)=813AA_BP=121
MRVSAPDPPPPHPARLCRLFQRPSLPSGRRCRCRRRRRHRARFRPRPPSAVQGPSVSAPGPRLPASPGPGPGTMSEKSVEAAAELSAKDL
KEKKEKVEEKASRKERKKEVVEDGEEEDEGEEEDGEEEEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPM
LAVPQIPSYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERAR
LLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEE
FEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFSWEDVDNILIPENRAHLSPEV
QLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQKLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLP
PPPTLEPTGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLSDNGINRLSLMAPDTPAGTPLSGV
GRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSPASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSE
CSLGLSGGLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSDHRSQDAPGGPPAQWRSHPCPPAGRAEAGRAETGRGWREALPC

--------------------------------------------------------------
>70114_70114_4_PTMS-BRPF3_PTMS_chr12_6879131_ENST00000309083_BRPF3_chr6_36169348_ENST00000534694_length(transcript)=3828nt_BP=480nt
GGCAGCTCTGCTGGTGCGGGGGCGGCGAGCCCGGGATCGAGCTACCGCGGCCGAGCGCGCCGGCCACCGCCTGCACCGCCCTTCCGCCCG
CCCTCCGGACGGCCGCAGCCCTGCGGGTCTCCGCTCCAGACCCACCCCCGCCCCACCCCGCGCGCCTCTGCCGCCTCTTCCAGAGACCCA
GCTTGCCGAGCGGCCGCCGCTGCCGCTGTCGCCGCCGCCGCCGCCACCGCGCCAGGTTCCGGCCGCGGCCACCCTCCGCCGTCCAGGGCC
CCTCCGTCTCGGCCCCGGGACCCCGGCTCCCCGCCAGCCCCGGCCCCGGCCCCGGCACCATGTCGGAGAAAAGCGTGGAGGCAGCGGCCG
AGTTGAGCGCCAAGGACCTGAAGGAGAAGAAGGAGAAGGTGGAGGAGAAGGCAAGCCGGAAAGAGCGAAAGAAAGAAGTGGTGGAGGATG
GAGAGGAGGAAGATGAAGGGGAAGAAGAAGATGGAGAGGAGGAAGAAGAGGAAGAGGTGGAGGAAGAAGAGCAGGAAGCTCAAGGCGGGG
TGAGTGGCTCCCTCAAGGGAGTGCCCAAGAAAAGCAAGATGAGTTTGAAGCAGAAGATCAAGAAGGAGCCAGAGGAAGCAGGCCAAGACA
CACCCTCCACTCTCCCCATGCTTGCTGTCCCACAGATACCCTCTTACAGGTTGAACAAGATCTGTAGTGGTCTCTCCTTTCAGAGGAAAA
ACCAGTTTATGCAGCGGCTTCACAATTATTGGCTGTTGAAGCGGCAGGCACGGAATGGTGTCCCTCTTATCCGGCGCTTGCACTCCCATC
TGCAGTCCCAAAGAAACGCTGAGCAGCGAGAGCAGGATGAGAAGACAAGTGCAGTGAAGGAGGAGCTGAAGTATTGGCAGAAGCTCCGGC
ATGACTTGGAGCGGGCGCGGCTGCTGATTGAGCTGATTCGGAAGAGAGAGAAGCTCAAACGAGAGCAGGTCAAAGTCCAGCAGGCTGCCA
TGGAGCTGGAGCTGATGCCATTCAATGTTCTGTTGAGGACAACACTGGACCTGCTGCAGGAGAAGGATCCTGCACACATCTTCGCAGAAC
CAGTCAACTTGAGTGAGGTTCCAGATTACCTGGAATTCATATCCAAGCCAATGGATTTTTCTACTATGAGGCGGAAGCTGGAGTCCCACC
TGTACCGCACCTTGGAGGAGTTTGAGGAGGACTTTAACCTTATAGTTACCAACTGCATGAAGTATAATGCTAAAGACACAATTTTCCACC
GAGCAGCTGTCCGCCTGCGGGACCTGGGAGGGGCCATCCTACGGCACGCCCGGCGGCAGGCAGAGAACATCGGCTATGACCCCGAGAGGG
GCACTCACCTGCCCGAGTCACCCAAATTGGAAGACTTTTACCGCTTCTCCTGGGAAGACGGCAGAAGCCTCCTGCTGCCCTTTGAAGACC
GCGGAGACCTGGAGCCCTTGGAGCTGGTGTGGGCCAAGTGCCGAGGCTACCCCTCCTACCCTGCCTTGATCATCGATCCCAAGATGCCCC
GGGAGGGCCTCCTGCACAATGGCGTTCCCATCCCTGTCCCCCCGCTGGACGTGCTGAAGCTGGGAGAGCAGAAACAGGCAGAGGCTGGAG
AGAAGCTCTTCCTTGTCCTCTTCTTTGACAACAAGCGCACCTGGCAGTGGCTTCCAAGGGACAAAGTCCTGCCCTTGGGTGTGGAAGACA
CCGTGGACAAGCTCAAGATGCTGGAAGGCCGCAAGACCAGCATCCGCAAGTCAGTGCAGGTGGCCTATGACCGTGCGATGATCCACCTGA
GCAGAGTCCGGGGGCCCCACTCCTTCGTCACTTCCAGCTACCTGTAAGGGCAGGGCTGGGCCTGCATCCGCTTGCCCTGCCTCCATCCCG
CAGGGCACAGAGAAGCCTCTTCTGCCCCTGCCAGATGTATGGCCGGCAGCTTCCCCCTCTCATGGTAGGCCAGGGACTGGGCTTTCTCCC
CACTAAGGGCAAGGCCCCAGTTTTGACCAATCGCATGGTTCTCCTGGCAGGCCTGCTGTGTGCCAAAAACTCCCACCCAAGGTCCCTCAG
GGGATATTTCACTGAAGAACCAGTTAGAAGTAGAAACAGCTGTGGGGCTTGGGCCCAGCTTAGGAGATTGCCCAGATGGCAAGAGGTCCT
GGGCTCCTTCTTGAGGGGCTGCCTGGCCCGCTCCATCCTACTCCCACTAACTACACCTCAGGGCGGGTGAGGTTCCGACACTGATCCCAG
AGATGCCGTGGATACGCCAGGGTCCCAGGGGGAATCTCCCCAAGCTCACACTCTCTCCCGCTTATCGCCTATTCTCACACCTCTTCTCGG
TCCCATCTTCTGCACCCATTGCCCAGTCTTGCTTTCTCTTTCCCATATTCCTTTTCTTTTTCTCTTGTGCCAAACTGACAGAAACCGTCA
CCACACTGGTCTTTTTCTTTAATGTCTCATTCCCCTTGAGGCCAGCTGCTATGCCAGGTGGTGTCTCTGCCAGGCTCCTCAGGCCCAGAC
AGAGGCCAGCCCACAACCTATGACCCCCTCCCCCAGGACACCACCTCCCACCCACAGACCTTCCCTTTAGCTGTTGACACAACTTCCCAG
CTCTGCAAGTGTGCCCCCTGGATCAAGGCGGGTCCCCTCTTGTTTTTTTCTTTGCTGCCACGAGGTGGTCCAAGCCTTCAGGGTGGGCTC
CTATCAGGCTGGGTGTGCGAGTGTCCATCTGTCCACATGGATGTCGAGGGTGGTTTGTGTGGAGCTGTGCTCGTCAGCTGGGTCTGCCCT
CTTCCCCCTTTTCTCCTTCTTCTCTCCTCATGGACTTTTTCTGCAATTGCAGTCTTAAGCTTCACTCTCCACCACCTGGATGGCATGGCG
CCTGCCACCAAACATCTTCCTGGCCTGCGCTCTGCCCTGCCCTGCCTAGCCTCTGCTACTCCCACTTCCCAACTCCAGGGAATGCATTAC
TTTTATTTCAAACCCTCTGCCTCCTTCCTTCTTTCTCTTCAACCCCCTCCCCACCTTCACCTTCTCAAAAATGGAAGGAAAAAAAAACTG
TGAATGGGGAATGCTGACTGACAAACCAACACAACTTTCAGAGGCTTCAGTGTCTGTTCTCTGGACATTTCTTTTCACCTCCTGAGCACC
AAAGTCGCAGGGCCAGTTGCAGGCCGCTGATTGCCATGTTGATTTTTAACCTGATATTCTTTTTAATTGTTTTAAATTTTTCATAGGGGA
GTTTTGGACAAAACAGTCACTGGGGAGATCACTGCCATTTTTACACACTTGACTTTTTAAAAATACAACCAACCAACCACCACAACTTCT
TATACATTTGGGACATGAGCCAGAGTTTAAAAGGGAACCAACAAAACACTATAACTTAAAAGGATGGGGTTTTGGATTTTGTATAATAAT
AAAAACAATACAGCATATGGCTAGGGAAGGACATGGTGTATATAATTGTAAAATACTGTTCTAAATTATTCAGGCCTATAGTTTCCATTA
CTGGAGTCCTCCATTGTGTGGCCACACAGTGTCGTTGATTTAAAGGAGCCAGTGCTTCCCCTCTCCCCAGGTAGTTGGTCAGCTGTGGAC
TCTGTGACCTTTGTCTAAACCTGTGTTGTAAGATCTTGGGACTTCCTCTCTTTCTATGTCTATCTCTTCCCCCCAACACTTTCTCTTCTT
AGTCTCTCTCTTTATTTTTCAATCTCTGAATATTTTAGTCTCTCTCTGAGTCTCATTTTTTAAAATGCTCTTTTAGAACGGGAAACGGCT

>70114_70114_4_PTMS-BRPF3_PTMS_chr12_6879131_ENST00000309083_BRPF3_chr6_36169348_ENST00000534694_length(amino acids)=578AA_BP=121
MRVSAPDPPPPHPARLCRLFQRPSLPSGRRCRCRRRRRHRARFRPRPPSAVQGPSVSAPGPRLPASPGPGPGTMSEKSVEAAAELSAKDL
KEKKEKVEEKASRKERKKEVVEDGEEEDEGEEEDGEEEEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPM
LAVPQIPSYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERAR
LLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEE
FEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFSWEDGRSLLLPFEDRGDLEPL
ELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PTMS-BRPF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTMS-BRPF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTMS-BRPF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource