Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DENND1A-CADPS2 (FusionGDB2 ID:HG57706TG93664)

Fusion Gene Summary for DENND1A-CADPS2

check button Fusion gene summary
Fusion gene informationFusion gene name: DENND1A-CADPS2
Fusion gene ID: hg57706tg93664
HgeneTgene
Gene symbol

DENND1A

CADPS2

Gene ID

57706

93664

Gene nameDENN domain containing 1Acalcium dependent secretion activator 2
SynonymsFAM31A|KIAA1608CAPS2
Cytomap('DENND1A')('CADPS2')

9q33.3

7q31.32

Type of geneprotein-codingprotein-coding
DescriptionDENN domain-containing protein 1ADENN/MADD domain containing 1Aconnecdenn 1calcium-dependent secretion activator 2CAPS-2Ca++-dependent secretion activator 2Ca2+ dependent secretion activator 2Ca2+-dependent activator protein for secretion 2calcium-dependent activator protein for secretion 2
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000373618, ENST00000373620, 
ENST00000373624, ENST00000394215, 
ENST00000394219, ENST00000473039, 
ENST00000542603, 
Fusion gene scores* DoF score18 X 18 X 14=453611 X 9 X 3=297
# samples 2611
** MAII scorelog2(26/4536*10)=-4.12483711191377
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/297*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DENND1A [Title/Abstract] AND CADPS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDENND1A(126414292)-CADPS2(122377122), # samples:3
Anticipated loss of major functional domain due to fusion event.DENND1A-CADPS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DENND1A-CADPS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DENND1A-CADPS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DENND1A-CADPS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DENND1A-CADPS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DENND1A-CADPS2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDENND1A

GO:0032483

regulation of Rab protein signal transduction

20937701


check buttonFusion gene breakpoints across DENND1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CADPS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1JI-01ADENND1Achr9

126414292

-CADPS2chr7

122377122

-


Top

Fusion Gene ORF analysis for DENND1A-CADPS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373618ENST00000476131DENND1Achr9

126414292

-CADPS2chr7

122377122

-
5CDS-intronENST00000373620ENST00000476131DENND1Achr9

126414292

-CADPS2chr7

122377122

-
5CDS-intronENST00000373624ENST00000476131DENND1Achr9

126414292

-CADPS2chr7

122377122

-
5CDS-intronENST00000394215ENST00000476131DENND1Achr9

126414292

-CADPS2chr7

122377122

-
5CDS-intronENST00000394219ENST00000476131DENND1Achr9

126414292

-CADPS2chr7

122377122

-
5UTR-3CDSENST00000473039ENST00000313070DENND1Achr9

126414292

-CADPS2chr7

122377122

-
5UTR-3CDSENST00000473039ENST00000334010DENND1Achr9

126414292

-CADPS2chr7

122377122

-
5UTR-3CDSENST00000473039ENST00000412584DENND1Achr9

126414292

-CADPS2chr7

122377122

-
5UTR-3CDSENST00000473039ENST00000449022DENND1Achr9

126414292

-CADPS2chr7

122377122

-
5UTR-3CDSENST00000542603ENST00000313070DENND1Achr9

126414292

-CADPS2chr7

122377122

-
5UTR-3CDSENST00000542603ENST00000334010DENND1Achr9

126414292

-CADPS2chr7

122377122

-
5UTR-3CDSENST00000542603ENST00000412584DENND1Achr9

126414292

-CADPS2chr7

122377122

-
5UTR-3CDSENST00000542603ENST00000449022DENND1Achr9

126414292

-CADPS2chr7

122377122

-
5UTR-intronENST00000473039ENST00000476131DENND1Achr9

126414292

-CADPS2chr7

122377122

-
5UTR-intronENST00000542603ENST00000476131DENND1Achr9

126414292

-CADPS2chr7

122377122

-
Frame-shiftENST00000373618ENST00000313070DENND1Achr9

126414292

-CADPS2chr7

122377122

-
Frame-shiftENST00000373618ENST00000334010DENND1Achr9

126414292

-CADPS2chr7

122377122

-
Frame-shiftENST00000373618ENST00000412584DENND1Achr9

126414292

-CADPS2chr7

122377122

-
Frame-shiftENST00000373618ENST00000449022DENND1Achr9

126414292

-CADPS2chr7

122377122

-
Frame-shiftENST00000394215ENST00000313070DENND1Achr9

126414292

-CADPS2chr7

122377122

-
Frame-shiftENST00000394215ENST00000334010DENND1Achr9

126414292

-CADPS2chr7

122377122

-
Frame-shiftENST00000394215ENST00000412584DENND1Achr9

126414292

-CADPS2chr7

122377122

-
Frame-shiftENST00000394215ENST00000449022DENND1Achr9

126414292

-CADPS2chr7

122377122

-
In-frameENST00000373620ENST00000313070DENND1Achr9

126414292

-CADPS2chr7

122377122

-
In-frameENST00000373620ENST00000334010DENND1Achr9

126414292

-CADPS2chr7

122377122

-
In-frameENST00000373620ENST00000412584DENND1Achr9

126414292

-CADPS2chr7

122377122

-
In-frameENST00000373620ENST00000449022DENND1Achr9

126414292

-CADPS2chr7

122377122

-
In-frameENST00000373624ENST00000313070DENND1Achr9

126414292

-CADPS2chr7

122377122

-
In-frameENST00000373624ENST00000334010DENND1Achr9

126414292

-CADPS2chr7

122377122

-
In-frameENST00000373624ENST00000412584DENND1Achr9

126414292

-CADPS2chr7

122377122

-
In-frameENST00000373624ENST00000449022DENND1Achr9

126414292

-CADPS2chr7

122377122

-
In-frameENST00000394219ENST00000313070DENND1Achr9

126414292

-CADPS2chr7

122377122

-
In-frameENST00000394219ENST00000334010DENND1Achr9

126414292

-CADPS2chr7

122377122

-
In-frameENST00000394219ENST00000412584DENND1Achr9

126414292

-CADPS2chr7

122377122

-
In-frameENST00000394219ENST00000449022DENND1Achr9

126414292

-CADPS2chr7

122377122

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373624DENND1Achr9126414292-ENST00000313070CADPS2chr7122377122-598782019342481351
ENST00000373624DENND1Achr9126414292-ENST00000334010CADPS2chr7122377122-610482019343651390
ENST00000373624DENND1Achr9126414292-ENST00000412584CADPS2chr7122377122-466882019342481351
ENST00000373624DENND1Achr9126414292-ENST00000449022CADPS2chr7122377122-453482019343711392
ENST00000394219DENND1Achr9126414292-ENST00000313070CADPS2chr7122377122-587971219041401316
ENST00000394219DENND1Achr9126414292-ENST00000334010CADPS2chr7122377122-599671219042571355
ENST00000394219DENND1Achr9126414292-ENST00000412584CADPS2chr7122377122-456071219041401316
ENST00000394219DENND1Achr9126414292-ENST00000449022CADPS2chr7122377122-442671219042631357
ENST00000373620DENND1Achr9126414292-ENST00000313070CADPS2chr7122377122-600683921242671351
ENST00000373620DENND1Achr9126414292-ENST00000334010CADPS2chr7122377122-612383921243841390
ENST00000373620DENND1Achr9126414292-ENST00000412584CADPS2chr7122377122-468783921242671351
ENST00000373620DENND1Achr9126414292-ENST00000449022CADPS2chr7122377122-455383921243901392

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373624ENST00000313070DENND1Achr9126414292-CADPS2chr7122377122-0.00013490.99986506
ENST00000373624ENST00000334010DENND1Achr9126414292-CADPS2chr7122377122-0.0001730570.99982697
ENST00000373624ENST00000412584DENND1Achr9126414292-CADPS2chr7122377122-0.0003292610.99967074
ENST00000373624ENST00000449022DENND1Achr9126414292-CADPS2chr7122377122-0.0002861510.99971384
ENST00000394219ENST00000313070DENND1Achr9126414292-CADPS2chr7122377122-0.0001239130.999876
ENST00000394219ENST00000334010DENND1Achr9126414292-CADPS2chr7122377122-0.0001604480.99983954
ENST00000394219ENST00000412584DENND1Achr9126414292-CADPS2chr7122377122-0.0003031460.99969685
ENST00000394219ENST00000449022DENND1Achr9126414292-CADPS2chr7122377122-0.0002646940.9997353
ENST00000373620ENST00000313070DENND1Achr9126414292-CADPS2chr7122377122-0.00013870.99986124
ENST00000373620ENST00000334010DENND1Achr9126414292-CADPS2chr7122377122-0.0001783240.9998217
ENST00000373620ENST00000412584DENND1Achr9126414292-CADPS2chr7122377122-0.0003410080.99965894
ENST00000373620ENST00000449022DENND1Achr9126414292-CADPS2chr7122377122-0.0002943090.9997056

Top

Fusion Genomic Features for DENND1A-CADPS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for DENND1A-CADPS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:126414292/chr7:122377122)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373618-81913_145174467.0DomainuDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373620-92113_145206560.0DomainuDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373624-92213_1452061010.0DomainuDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000394215-82013_145176530.0DomainuDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000394219-72113_1451741021.0DomainuDENN
TgeneCADPS2chr9:126414292chr7:122377122ENST00000412584028350_4641131256.0DomainC2
TgeneCADPS2chr9:126414292chr7:122377122ENST00000412584028487_5901131256.0DomainPH
TgeneCADPS2chr9:126414292chr7:122377122ENST00000412584028885_10561131256.0DomainMHD1
TgeneCADPS2chr9:126414292chr7:122377122ENST00000449022030350_4641131297.0DomainC2
TgeneCADPS2chr9:126414292chr7:122377122ENST00000449022030487_5901131297.0DomainPH
TgeneCADPS2chr9:126414292chr7:122377122ENST00000449022030885_10561131297.0DomainMHD1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373618-819649_995174467.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373620-921649_995206560.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373624-922649_9952061010.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126414292chr7:122377122ENST00000394215-820649_995176530.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126414292chr7:122377122ENST00000394219-721649_9951741021.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126414292chr7:122377122ENST00000542603-114649_9950795.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373618-819162_298174467.0DomaincDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373618-819300_378174467.0DomaindDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373620-921162_298206560.0DomaincDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373620-921300_378206560.0DomaindDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373624-922162_2982061010.0DomaincDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373624-922300_3782061010.0DomaindDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000394215-820162_298176530.0DomaincDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000394215-820300_378176530.0DomaindDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000394219-721162_2981741021.0DomaincDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000394219-721300_3781741021.0DomaindDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000542603-11413_1450795.0DomainuDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000542603-114162_2980795.0DomaincDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000542603-114300_3780795.0DomaindDENN
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373618-819381_385174467.0MotifFXDXF motif
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373618-819569_578174467.0MotifClathrin box
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373620-921381_385206560.0MotifFXDXF motif
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373620-921569_578206560.0MotifClathrin box
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373624-922381_3852061010.0MotifFXDXF motif
HgeneDENND1Achr9:126414292chr7:122377122ENST00000373624-922569_5782061010.0MotifClathrin box
HgeneDENND1Achr9:126414292chr7:122377122ENST00000394215-820381_385176530.0MotifFXDXF motif
HgeneDENND1Achr9:126414292chr7:122377122ENST00000394215-820569_578176530.0MotifClathrin box
HgeneDENND1Achr9:126414292chr7:122377122ENST00000394219-721381_3851741021.0MotifFXDXF motif
HgeneDENND1Achr9:126414292chr7:122377122ENST00000394219-721569_5781741021.0MotifClathrin box
HgeneDENND1Achr9:126414292chr7:122377122ENST00000542603-114381_3850795.0MotifFXDXF motif
HgeneDENND1Achr9:126414292chr7:122377122ENST00000542603-114569_5780795.0MotifClathrin box


Top

Fusion Gene Sequence for DENND1A-CADPS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22191_22191_1_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000373620_CADPS2_chr7_122377122_ENST00000313070_length(transcript)=6006nt_BP=839nt
ACGCGCGCCGGCGACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAG
CGGGCGGGCCCCAGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGC
GCCGAGCGGGGCCCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATG
TTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTC
TACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTG
ACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCG
AGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACA
AACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATAC
CTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGA
TACTCATCATTTGCAGCAAACTCAGCACTCTTAACAAACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAA
CCCAAATTGTAGCTGACGAAGCATTTTGCAACGCAGTTCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCCAGAATGGTAC
AGAGTGGAGGGTGTTCTGCTAATGACTTCAGAGAAGTATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCT
TGAGCAAAGAGACAGTGTTGAGCTCATGGATAGCCAAATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAGCCAAATAGAA
TGGCCCTAAGTGCAGTGTCTGAACTTATTCTGAGCAAGGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAAC
ACCAGCTCCTTTATAATGCATGTCAGCTGGATAACGCAGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGGCTGCAATTGG
CAGATAAAATGGCAAAGGAAAGAAAATTCCCCAAATTTATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGA
ATTTGCTAATGGCCAATTTGGAAAGTCTTCCAGTTTCGAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCACAGAACTCTG
CATTTTTGGACATAGGAGATGAGAATGAGATTCAGCTGTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAG
TGCAAGGCCTGAAGTCAGTTGCTCCCAATCGAATTGTTTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGACCAGGCCGAAG
CCTCAAGGCCACAATGGGGGACTCAAGGAGATTTCACCACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTG
GAGTTCTGGCCCTGGAAGATAAAGAACTGGGAAGGGTGATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTACACCGAATGG
TAGTTCCAAAAAATAGCCAGGATTCTGACTTAAAAATCAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGCATAGTGGATATC
TGTATGCCCTTGGACAGAAGGTTTGGAAAAGATGGAAAAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTTGCTATGTGCA
GTTATAGAGAAAAGAAGTCTGAACCACAAGAATTAATGCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGG
GTGGTTGTATGTTCTTTAATGCTGTTAAAGAAGGAGATACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTATGGGTTCAAG
CCATGTATAGGGCCACAGGTCAATCATATAAACCAGTTCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAG
ATGCTCAGCTTTATGCAGATCGTTTTCAGAAACATGGTATGGATGAGTTTATTTCTGCAAACCCCTGCAAGCTTGATCATGCCTTCCTTT
TTAGAATACTCCAGAGGCAGACTTTGGATCACAGACTGAATGATTCCTATTCTTGCTTGGGATGGTTTAGCCCTGGCCAAGTCTTTGTGT
TAGATGAGTACTGTGCCCGTTATGGTGTGAGAGGCTGTCACAGACATCTCTGCTACCTTGCAGAACTGATGGAACATTCAGAAAATGGTG
CTGTCATTGACCCTACCCTGCTCCATTACAGCTTTGCATTCTGTGCCTCTCATGTGCACGGCAACAGGCCTGATGGAATTGGGACTGTTT
CAGTGGAAGAAAAAGAAAGATTTGAGGAGATAAAAGAGAGACTCTCTTCCCTTTTAGAAAATCAGATAAGCCATTTCAGATACTGTTTTC
CCTTTGGACGACCTGAAGGTGCTCTAAAAGCTACACTTTCATTACTTGAAAGGGTTTTAATGAAAGATATTGCCACTCCCATACCAGCAG
AAGAGGTGAAGAAAGTGGTCAGAAAATGTCTCGAGAAAGCTGCCTTGATCAATTACACTAGACTCACAGAATATGCCAAAATAGAAGAGA
CCATGAACCAGGCATCTCCTGCTAGAAAGCTGGAAGAGATTCTTCATCTGGCAGAGCTCTGCATAGAAGTCTTACAGCAGAATGAAGAGC
ATCATGCAGAGGCATTTGCCTGGTGGCCTGATTTATTGGCTGAACATGCAGAGAAATTTTGGGCTTTATTTACAGTGGATATGGACACTG
CACTAGAGGCTCAACCGCAAGACTCCTGGGATAGTTTTCCTCTTTTCCAACTGCTTAATAATTTCCTCCGAAATGACACACTTTTGTGTA
ATGGAAAATTTCACAAACACTTGCAAGAAATCTTTGTACCCTTGGTTGTCCGCTATGTGGATCTCATGGAGTCTTCCATCGCCCAGTCAA
TTCACAGAGGTTTTGAGCAGGAGACATGGCAGCCTGTCAACAATGGCTCAGCAACATCAGAAGACCTTTTTTGGAAGCTTGATGCACTGC
AAATGTTTGTCTTTGATCTGCACTGGCCAGAACAGGAATTTGCCCACCACTTAGAGCAAAGACTTAAACTAATGGCCAGTGATATGCTAG
AGGCCTGTGTCAAAAGAACAAGAACTGCATTTGAACTCAAGCTACAAAAGGCAAGCAAAACAACTGACTTGCGCATTCCAGCTTCCGTTT
GCACTATGTTTAATGTATTAGTCGATGCCAAAAAGCAAAGCACCAAACTCTGTGCCCTGGATGGAGGACAAGAGGTATGTAGAATTTTTC
AACAGTACCATTCAAAAATAGATGATCTGATCGACAACAGTGTAAAAGAAATCATTTCACTGTTAGTTTCAAAGTTTGTTTCAGTGTTGG
AAGGCGTGTTGTCTAAGCTGTCAAGGTATGATGAAGGCACTTTCTTTTCATCCATTCTGTCATTCACTGTGAAAGCAGCTGCAAAATATG
TTGATGTTCCAAAACCAGGAATGGATCTGGCAGACACCTATATTATGTTTGTTCGGCAAAACCAAGATATTCTTCGAGAAAAGGTCAATG
AGGAAATGTATATAGAAAAGTTATTTGATCAATGGTACAGCAGTTCCATGAAAGTCATTTGCGTGTGGTTGACTGATAGATTAGACCTCC
AACTCCATATTTACCAGCTGAAGACGCTCATCAAGATTGTGAAGAAAACCTACAGGGACTTTCGATTGCAGGGTGTGTTGGAAGGAACAC
TGAACAGTAAGACTTATGATACTGTGCACAGACGTTTAACAGTAGAGGAGGCCACAGCCTCTGTTTCAGAAGGAGGAGGACTTCAGGGCA
TTACTATGAAAGACAGTGACGAAGAAGAAGAAGGCTGATATCACACAGCTTTGCAGAAGGAAGGAAGACCTTGATCGACATTGTTTTTTA
TTTTTTTAACCTTGTCCTTGTAATTACATTCATTGTTTGTTTTGGCCAAATAAAAATGCTTGTATTTCTTTAAAAAGTAAGCCTGAATGT
AGAGTAAAAGGGGAAATGCCAAGATTTTGGGGTTTTTTTGTTTCCTTTTTTTGTTTGTTTGTTTGTTTGTTTTTTTGGAGAAGAGCATCC
TCTTTTGTGTAGTTTGACCTAAAAATGAACCTTGGCTCTGCTTGTGATCAGAACATGAACTTTTTTTTTTAAAGAAGATTTGAGCATTTT
TCTGTAATCACATCAAAATGATGTTTTCTGTGTAAAGCGAGATACATATTTCTCATAATGCAGCATTGTGAGAAGTCAGTTCGGACCACT
GCACCAACACTGTCGTATCCTTGTTAAAATGGTGTGTACCTTACAAATTATAATTTATGTGCCAGGTTCGTTTTGTACTTAATTTGCTAT
TATTGTGATGTGTATAAAATCTTTAATCTTGGTTCTTAGTACTTTGAATTGGTCTACAGGTATATTCCTGGGATGAAAGGATTGCCAAAC
CCAAATATAGACTAGATTATCCAATGGGTTTGTGTCTTTGTTCCATTCTCAACATTTCTTCTTTCAACTATAAGTAATCCCCAGGTGTGG
GGTAGCAAGTGTGCTTCCGTCAAGATACCATATTCTCCTGCTCCAGTATAACAGCTTGCAGGCAATAAAAATCTATTTGCTCATAACTAC
TTCTGTATTTATTAGACTTATATAGAGCAAATGCAGTAAAAGAGGTTTGCAGTGTTTCAAACATCCCAACTATCTGACTCTGTGTTTTTG
TTTCTTGAGTTTTTTGTTTGTTTTGTTTGTAATATTTTGTTTTTAATCAAATGAGTAAAAGATAGTAACACTGACTGTTCTTTGTACCTA
ATAGGCACATACATTGTTAAAAGAATTACTATGACAGCATATTTCCATAGCAGAGGAAATATATATTTCATATATTATTAGTTAATATTA
GTAATCAATGTTAACTAATAATTAGTAATGTTAGTAATATTAACTAGTAATTCACATTATTAGTGGTTCTCTCAAAATATTTTCTTGCTA
GGGTTTGAGAGATAATTGTATTATGTTGCGTAAGTTCTCTATGAATTATTTTTGTGATATTTCCCAAAACATATTGGCAGATTGTGCTAC
TGCATTTATTAATAAGTAATTTTTAAATGAAGGCAGTTAATGCAGAATAAGTGGAGGTATCCCTGCATTTATGAAAACGTTTATTCTGAA
ACTTTAGAAATGAAACAACTTGGACCTCCAGATTCGTTCTCCCATGGTGTAATAAGTGGTCGTTAGGTACCTAGACTAGCCTTAAAAATC
TATTTAATCTACAGTTACTATTTAGCATTGTTTTGGCTCATTTTCTGGGCCCTAGGGCTAAGATAACAAACAAGGAAATTTCTTCCTTCT
TCCGGGATTAAAGACTAACTCTACCAACTCACTATCTTTGAAAGGCAGTTTGGGAATGTTCTCCCTCCTTTTCTTCTCTATTCACACACC
AAATACTATTTTCTCCAAACCCTCAAATGTCCAGTCATGCTATCCCAAACTCTCCAATGGCACCATCCCCAAGCTTGCTGTTCCACGACA
CATTGCTCTGTACTTAGTAATTACCCACCCTTCTTTTCCTTTCAATAAAATGTCCATTTCCTTGAT

>22191_22191_1_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000373620_CADPS2_chr7_122377122_ENST00000313070_length(amino acids)=1351AA_BP=209
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFR
EVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLD
NADEQAAQIRRELDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEI
QLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELG
RVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQE
LMQLEGYTVDYTDPHPGLQGGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLYADRFQK
HGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYS
FAFCASHVHGNRPDGIGTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKKVVRKCL
EKAALINYTRLTEYAKIEETMNQASPARKLEEILHLAELCIEVLQQNEEHHAEAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWD
SFPLFQLLNNFLRNDTLLCNGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQPVNNGSATSEDLFWKLDALQMFVFDLHWPE
QEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKASKTTDLRIPASVCTMFNVLVDAKKQSTKLCALDGGQEVCRIFQQYHSKIDDLI
DNSVKEIISLLVSKFVSVLEGVLSKLSRYDEGTFFSSILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQDILREKVNEEMYIEKLFDQ
WYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTYRDFRLQGVLEGTLNSKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEE
G

--------------------------------------------------------------
>22191_22191_2_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000373620_CADPS2_chr7_122377122_ENST00000334010_length(transcript)=6123nt_BP=839nt
ACGCGCGCCGGCGACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAG
CGGGCGGGCCCCAGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGC
GCCGAGCGGGGCCCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATG
TTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTC
TACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTG
ACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCG
AGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACA
AACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATAC
CTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGA
TACTCATCATTTGCAGCAAACTCAGCACTCTTAACAAACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAA
CCCAAATTGTAGCTGACGAAGCATTTTGCAACGCAGTTCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCCAGAATGGTAC
AGAGTGGAGGGTGTTCTGCTAATGACTTCAGAGAAGTATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCT
TGAGCAAAGAGACAGTGTTGAGCTCATGGATAGCCAAATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAGCCAAATAGAA
TGGCCCTAAGTGCAGTGTCTGAACTTATTCTGAGCAAGGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAAC
ACCAGCTCCTTTATAATGCATGTCAGCTGGATAACGCAGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGGCTGCAATTGG
CAGATAAAATGGCAAAGGAAAGAAAATTCCCCAAATTTATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGA
ATTTGCTAATGGCCAATTTGGAAAGTCTTCCAGTTTCGAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCACAGAACTCTG
CATTTTTGGACATAGGAGATGAGAATGAGATTCAGCTGTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAG
TGCAAGGCCTGAAGTCAGTTGCTCCCAATCGAATTGTTTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGACCAGGCCGAAG
CCTCAAGGCCACAATGGGGGACTCAAGGAGATTTCACCACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTG
GAGTTCTGGCCCTGGAAGATAAAGAACTGGGAAGGGTGATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTACACCGAATGG
TAGTTCCAAAAAATAGCCAGGATTCTGACTTAAAAATCAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGCATAGTGGATATC
TGTATGCCCTTGGACAGAAGGTTTGGAAAAGATGGAAAAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTTGCTATGTGCA
GTTATAGAGAAAAGAAGTCTGAACCACAAGAATTAATGCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGG
GTGGTTGTATGTTCTTTAATGCTGTTAAAGAAGGAGATACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTATGGGTTCAAG
CCATGTATAGGGCCACAGGTCAATCATATAAACCAGTTCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAG
ATGCTCAGCTTTCTGAATTTACAGATGCAGATCGTTTTCAGAAACATGGTATGGATGAGTTTATTTCTGCAAACCCCTGCAAGCTTGATC
ATGCCTTCCTTTTTAGAATACTCCAGAGGCAGACTTTGGATCACAGACTGAATGATTCCTATTCTTGCTTGGGATGGTTTAGCCCTGGCC
AAGTCTTTGTGTTAGATGAGTACTGTGCCCGTTATGGTGTGAGAGGCTGTCACAGACATCTCTGCTACCTTGCAGAACTGATGGAACATT
CAGAAAATGGTGCTGTCATTGACCCTACCCTGCTCCATTACAGCTTTGCATTCTGTGCCTCTCATGTGCACGGCAACAGGCCTGATGGAA
TTGGGACTGTTTCAGTGGAAGAAAAAGAAAGATTTGAGGAGATAAAAGAGAGACTCTCTTCCCTTTTAGAAAATCAGATAAGCCATTTCA
GATACTGTTTTCCCTTTGGACGACCTGAAGGTGCTCTAAAAGCTACACTTTCATTACTTGAAAGGGTTTTAATGAAAGATATTGCCACTC
CCATACCAGCAGAAGAGGTGAAGAAAGTGGTCAGAAAATGTCTCGAGAAAGCTGCCTTGATCAATTACACTAGACTCACAGAATATGCCA
AAATAGAAGAGACCATGAACCAGGCATCTCCTGCTAGAAAGCTGGAAGAGATTCTTCATCTGGCAGAGCTCTGCATAGAAGTCTTACAGC
AGAATGAAGAGCATCATGCAGAGGCATTTGCCTGGTGGCCTGATTTATTGGCTGAACATGCAGAGAAATTTTGGGCTTTATTTACAGTGG
ATATGGACACTGCACTAGAGGCTCAACCGCAAGACTCCTGGGATAGTTTTCCTCTTTTCCAACTGCTTAATAATTTCCTCCGAAATGACA
CACTTTTGTGTAATGGAAAATTTCACAAACACTTGCAAGAAATCTTTGTACCCTTGGTTGTCCGCTATGTGGATCTCATGGAGTCTTCCA
TCGCCCAGTCAATTCACAGAGGTTTTGAGCAGGAGACATGGCAGCCTGTCAAGAATATCGCCAACAGTCTTCCCAATGTAGCTCTTCCAA
AAGTTCCAAGTCTGCCTCTTAATCTTCCACAGATTCCTAACATTTCTACTGCTTCGTGGATGCCTTCTTTATATGAGTCCACCAATGGCT
CAGCAACATCAGAAGACCTTTTTTGGAAGCTTGATGCACTGCAAATGTTTGTCTTTGATCTGCACTGGCCAGAACAGGAATTTGCCCACC
ACTTAGAGCAAAGACTTAAACTAATGGCCAGTGATATGCTAGAGGCCTGTGTCAAAAGAACAAGAACTGCATTTGAACTCAAGCTACAAA
AGGCAAGCAAAACAACTGACTTGCGCATTCCAGCTTCCGTTTGCACTATGTTTAATGTATTAGTCGATGCCAAAAAGCAAAGCACCAAAC
TCTGTGCCCTGGATGGAGGACAAGAGCAACAGTACCATTCAAAAATAGATGATCTGATCGACAACAGTGTAAAAGAAATCATTTCACTGT
TAGTTTCAAAGTTTGTTTCAGTGTTGGAAGGCGTGTTGTCTAAGCTGTCAAGGTATGATGAAGGCACTTTCTTTTCATCCATTCTGTCAT
TCACTGTGAAAGCAGCTGCAAAATATGTTGATGTTCCAAAACCAGGAATGGATCTGGCAGACACCTATATTATGTTTGTTCGGCAAAACC
AAGATATTCTTCGAGAAAAGGTCAATGAGGAAATGTATATAGAAAAGTTATTTGATCAATGGTACAGCAGTTCCATGAAAGTCATTTGCG
TGTGGTTGACTGATAGATTAGACCTCCAACTCCATATTTACCAGCTGAAGACGCTCATCAAGATTGTGAAGAAAACCTACAGGGACTTTC
GATTGCAGGGTGTGTTGGAAGGAACACTGAACAGTAAGACTTATGATACTGTGCACAGACGTTTAACAGTAGAGGAGGCCACAGCCTCTG
TTTCAGAAGGAGGAGGACTTCAGGGCATTACTATGAAAGACAGTGACGAAGAAGAAGAAGGCTGATATCACACAGCTTTGCAGAAGGAAG
GAAGACCTTGATCGACATTGTTTTTTATTTTTTTAACCTTGTCCTTGTAATTACATTCATTGTTTGTTTTGGCCAAATAAAAATGCTTGT
ATTTCTTTAAAAAGTAAGCCTGAATGTAGAGTAAAAGGGGAAATGCCAAGATTTTGGGGTTTTTTTGTTTCCTTTTTTTGTTTGTTTGTT
TGTTTGTTTTTTTGGAGAAGAGCATCCTCTTTTGTGTAGTTTGACCTAAAAATGAACCTTGGCTCTGCTTGTGATCAGAACATGAACTTT
TTTTTTTAAAGAAGATTTGAGCATTTTTCTGTAATCACATCAAAATGATGTTTTCTGTGTAAAGCGAGATACATATTTCTCATAATGCAG
CATTGTGAGAAGTCAGTTCGGACCACTGCACCAACACTGTCGTATCCTTGTTAAAATGGTGTGTACCTTACAAATTATAATTTATGTGCC
AGGTTCGTTTTGTACTTAATTTGCTATTATTGTGATGTGTATAAAATCTTTAATCTTGGTTCTTAGTACTTTGAATTGGTCTACAGGTAT
ATTCCTGGGATGAAAGGATTGCCAAACCCAAATATAGACTAGATTATCCAATGGGTTTGTGTCTTTGTTCCATTCTCAACATTTCTTCTT
TCAACTATAAGTAATCCCCAGGTGTGGGGTAGCAAGTGTGCTTCCGTCAAGATACCATATTCTCCTGCTCCAGTATAACAGCTTGCAGGC
AATAAAAATCTATTTGCTCATAACTACTTCTGTATTTATTAGACTTATATAGAGCAAATGCAGTAAAAGAGGTTTGCAGTGTTTCAAACA
TCCCAACTATCTGACTCTGTGTTTTTGTTTCTTGAGTTTTTTGTTTGTTTTGTTTGTAATATTTTGTTTTTAATCAAATGAGTAAAAGAT
AGTAACACTGACTGTTCTTTGTACCTAATAGGCACATACATTGTTAAAAGAATTACTATGACAGCATATTTCCATAGCAGAGGAAATATA
TATTTCATATATTATTAGTTAATATTAGTAATCAATGTTAACTAATAATTAGTAATGTTAGTAATATTAACTAGTAATTCACATTATTAG
TGGTTCTCTCAAAATATTTTCTTGCTAGGGTTTGAGAGATAATTGTATTATGTTGCGTAAGTTCTCTATGAATTATTTTTGTGATATTTC
CCAAAACATATTGGCAGATTGTGCTACTGCATTTATTAATAAGTAATTTTTAAATGAAGGCAGTTAATGCAGAATAAGTGGAGGTATCCC
TGCATTTATGAAAACGTTTATTCTGAAACTTTAGAAATGAAACAACTTGGACCTCCAGATTCGTTCTCCCATGGTGTAATAAGTGGTCGT
TAGGTACCTAGACTAGCCTTAAAAATCTATTTAATCTACAGTTACTATTTAGCATTGTTTTGGCTCATTTTCTGGGCCCTAGGGCTAAGA
TAACAAACAAGGAAATTTCTTCCTTCTTCCGGGATTAAAGACTAACTCTACCAACTCACTATCTTTGAAAGGCAGTTTGGGAATGTTCTC
CCTCCTTTTCTTCTCTATTCACACACCAAATACTATTTTCTCCAAACCCTCAAATGTCCAGTCATGCTATCCCAAACTCTCCAATGGCAC
CATCCCCAAGCTTGCTGTTCCACGACACATTGCTCTGTACTTAGTAATTACCCACCCTTCTTTTCCTTTCAATAAAATGTCCATTTCCTT
GAT

>22191_22191_2_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000373620_CADPS2_chr7_122377122_ENST00000334010_length(amino acids)=1390AA_BP=209
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFR
EVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLD
NADEQAAQIRRELDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEI
QLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELG
RVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQE
LMQLEGYTVDYTDPHPGLQGGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLSEFTDAD
RFQKHGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTL
LHYSFAFCASHVHGNRPDGIGTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKKVV
RKCLEKAALINYTRLTEYAKIEETMNQASPARKLEEILHLAELCIEVLQQNEEHHAEAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQ
DSWDSFPLFQLLNNFLRNDTLLCNGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQPVKNIANSLPNVALPKVPSLPLNLPQ
IPNISTASWMPSLYESTNGSATSEDLFWKLDALQMFVFDLHWPEQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKASKTTDLRIP
ASVCTMFNVLVDAKKQSTKLCALDGGQEQQYHSKIDDLIDNSVKEIISLLVSKFVSVLEGVLSKLSRYDEGTFFSSILSFTVKAAAKYVD
VPKPGMDLADTYIMFVRQNQDILREKVNEEMYIEKLFDQWYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTYRDFRLQGVLEGTLN
SKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEEG

--------------------------------------------------------------
>22191_22191_3_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000373620_CADPS2_chr7_122377122_ENST00000412584_length(transcript)=4687nt_BP=839nt
ACGCGCGCCGGCGACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAG
CGGGCGGGCCCCAGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGC
GCCGAGCGGGGCCCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATG
TTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTC
TACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTG
ACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCG
AGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACA
AACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATAC
CTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGA
TACTCATCATTTGCAGCAAACTCAGCACTCTTAACAAACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAA
CCCAAATTGTAGCTGACGAAGCATTTTGCAACGCAGTTCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCCAGAATGGTAC
AGAGTGGAGGGTGTTCTGCTAATGACTTCAGAGAAGTATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCT
TGAGCAAAGAGACAGTGTTGAGCTCATGGATAGCCAAATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAGCCAAATAGAA
TGGCCCTAAGTGCAGTGTCTGAACTTATTCTGAGCAAGGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAAC
ACCAGCTCCTTTATAATGCATGTCAGCTGGATAACGCAGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGGCTGCAATTGG
CAGATAAAATGGCAAAGGAAAGAAAATTCCCCAAATTTATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGA
ATTTGCTAATGGCCAATTTGGAAAGTCTTCCAGTTTCGAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCACAGAACTCTG
CATTTTTGGACATAGGAGATGAGAATGAGATTCAGCTGTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAG
TGCAAGGCCTGAAGTCAGTTGCTCCCAATCGAATTGTTTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGACCAGGCCGAAG
CCTCAAGGCCACAATGGGGGACTCAAGGAGATTTCACCACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTG
GAGTTCTGGCCCTGGAAGATAAAGAACTGGGAAGGGTGATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTACACCGAATGG
TAGTTCCAAAAAATAGCCAGGATTCTGACTTAAAAATCAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGCATAGTGGATATC
TGTATGCCCTTGGACAGAAGGTTTGGAAAAGATGGAAAAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTTGCTATGTGCA
GTTATAGAGAAAAGAAGTCTGAACCACAAGAATTAATGCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGG
GTGGTTGTATGTTCTTTAATGCTGTTAAAGAAGGAGATACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTATGGGTTCAAG
CCATGTATAGGGCCACAGGTCAATCATATAAACCAGTTCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAG
ATGCTCAGCTTTATGCAGATCGTTTTCAGAAACATGGTATGGATGAGTTTATTTCTGCAAACCCCTGCAAGCTTGATCATGCCTTCCTTT
TTAGAATACTCCAGAGGCAGACTTTGGATCACAGACTGAATGATTCCTATTCTTGCTTGGGATGGTTTAGCCCTGGCCAAGTCTTTGTGT
TAGATGAGTACTGTGCCCGTTATGGTGTGAGAGGCTGTCACAGACATCTCTGCTACCTTGCAGAACTGATGGAACATTCAGAAAATGGTG
CTGTCATTGACCCTACCCTGCTCCATTACAGCTTTGCATTCTGTGCCTCTCATGTGCACGGCAACAGGCCTGATGGAATTGGGACTGTTT
CAGTGGAAGAAAAAGAAAGATTTGAGGAGATAAAAGAGAGACTCTCTTCCCTTTTAGAAAATCAGATAAGCCATTTCAGATACTGTTTTC
CCTTTGGACGACCTGAAGGTGCTCTAAAAGCTACACTTTCATTACTTGAAAGGGTTTTAATGAAAGATATTGCCACTCCCATACCAGCAG
AAGAGGTGAAGAAAGTGGTCAGAAAATGTCTCGAGAAAGCTGCCTTGATCAATTACACTAGACTCACAGAATATGCCAAAATAGAAGAGA
CCATGAACCAGGCATCTCCTGCTAGAAAGCTGGAAGAGATTCTTCATCTGGCAGAGCTCTGCATAGAAGTCTTACAGCAGAATGAAGAGC
ATCATGCAGAGGCATTTGCCTGGTGGCCTGATTTATTGGCTGAACATGCAGAGAAATTTTGGGCTTTATTTACAGTGGATATGGACACTG
CACTAGAGGCTCAACCGCAAGACTCCTGGGATAGTTTTCCTCTTTTCCAACTGCTTAATAATTTCCTCCGAAATGACACACTTTTGTGTA
ATGGAAAATTTCACAAACACTTGCAAGAAATCTTTGTACCCTTGGTTGTCCGCTATGTGGATCTCATGGAGTCTTCCATCGCCCAGTCAA
TTCACAGAGGTTTTGAGCAGGAGACATGGCAGCCTGTCAACAATGGCTCAGCAACATCAGAAGACCTTTTTTGGAAGCTTGATGCACTGC
AAATGTTTGTCTTTGATCTGCACTGGCCAGAACAGGAATTTGCCCACCACTTAGAGCAAAGACTTAAACTAATGGCCAGTGATATGCTAG
AGGCCTGTGTCAAAAGAACAAGAACTGCATTTGAACTCAAGCTACAAAAGGCAAGCAAAACAACTGACTTGCGCATTCCAGCTTCCGTTT
GCACTATGTTTAATGTATTAGTCGATGCCAAAAAGCAAAGCACCAAACTCTGTGCCCTGGATGGAGGACAAGAGTTTGGTAGTCAATGGC
AACAGTACCATTCAAAAATAGATGATCTGATCGACAACAGTGTAAAAGAAATCATTTCACTGTTAGTTTCAAAGTTTGTTTCAGTGTTGG
AAGGCGTGTTGTCTAAGCTGTCAAGGTATGATGAAGGCACTTTCTTTTCATCCATTCTGTCATTCACTGTGAAAGCAGCTGCAAAATATG
TTGATGTTCCAAAACCAGGAATGGATCTGGCAGACACCTATATTATGTTTGTTCGGCAAAACCAAGATATTCTTCGAGAAAAGGTCAATG
AGGAAATGTATATAGAAAAGTTATTTGATCAATGGTACAGCAGTTCCATGAAAGTCATTTGCGTGTGGTTGACTGATAGATTAGACCTCC
AACTCCATATTTACCAGCTGAAGACGCTCATCAAGATTGTGAAGAAAACCTACAGGGACTTTCGATTGCAGGGTGTGTTGGAAGGAACAC
TGAACAGTAAGACTTATGATACTGTGCACAGACGTTTAACAGTAGAGGAGGCCACAGCCTCTGTTTCAGAAGGAGGAGGACTTCAGGGCA
TTACTATGAAAGACAGTGACGAAGAAGAAGAAGGCTGATATCACACAGCTTTGCAGAAGGAAGGAAGACCTTGATCGACATTGTTTTTTA
TTTTTTTAACCTTGTCCTTGTAATTACATTCATTGTTTGTTTTGGCCAAATAAAAATGCTTGTATTTCTTTAAAAAGTAAGCCTGAATGT
AGAGTAAAAGGGGAAATGCCAAGATTTTGGGGTTTTTTTGTTTCCTTTTTTTGTTTGTTTGTTTGTTTGTTTTTTTGGAGAAGAGCATCC
TCTTTTGTGTAGTTTGACCTAAAAATGAACCTTGGCTCTGCTTGTGATCAGAACATGAACTTTTTTTTTTAAAGAAGATTTGAGCATTTT
TCTGTAATCACATCAAAATGATGTTTTCTGTGTAAAGCGAGATACATATTTCTCATAATGCAGCATTGTGAGAAGTCAGTTCGGACCACT
GCACCAA

>22191_22191_3_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000373620_CADPS2_chr7_122377122_ENST00000412584_length(amino acids)=1351AA_BP=209
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFR
EVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLD
NADEQAAQIRRELDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEI
QLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELG
RVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQE
LMQLEGYTVDYTDPHPGLQGGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLYADRFQK
HGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYS
FAFCASHVHGNRPDGIGTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKKVVRKCL
EKAALINYTRLTEYAKIEETMNQASPARKLEEILHLAELCIEVLQQNEEHHAEAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWD
SFPLFQLLNNFLRNDTLLCNGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQPVNNGSATSEDLFWKLDALQMFVFDLHWPE
QEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKASKTTDLRIPASVCTMFNVLVDAKKQSTKLCALDGGQEFGSQWQQYHSKIDDLI
DNSVKEIISLLVSKFVSVLEGVLSKLSRYDEGTFFSSILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQDILREKVNEEMYIEKLFDQ
WYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTYRDFRLQGVLEGTLNSKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEE
G

--------------------------------------------------------------
>22191_22191_4_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000373620_CADPS2_chr7_122377122_ENST00000449022_length(transcript)=4553nt_BP=839nt
ACGCGCGCCGGCGACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAG
CGGGCGGGCCCCAGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGC
GCCGAGCGGGGCCCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATG
TTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTC
TACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTG
ACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCG
AGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACA
AACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATAC
CTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGA
TACTCATCATTTGCAGCAAACTCAGCACTCTTAACAAACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAA
CCCAAATTGTAGCTGACGAAGCATTTTGCAACGCAGTTCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCCAGAATGGTAC
AGAGTGGAGGGTGTTCTGCTAATGACTTCAGAGAAGTATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCT
TGAGCAAAGAGACAGTGTTGAGCTCATGGATAGCCAAATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAGCCAAATAGAA
TGGCCCTAAGTGCAGTGTCTGAACTTATTCTGAGCAAGGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAAC
ACCAGCTCCTTTATAATGCATGTCAGCTGGATAACGCAGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGGCTGCAATTGG
CAGATAAAATGGCAAAGGAAAGAAAATTCCCCAAATTTATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGA
ATTTGCTAATGGCCAATTTGGAAAGTCTTCCAGTTTCGAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCACAGAACTCTG
CATTTTTGGACATAGGAGATGAGAATGAGATTCAGCTGTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAG
TGCAAGGCCTGAAGTCAGTTGCTCCCAATCGAATTGTTTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGACCAGGCCGAAG
CCTCAAGGCCACAATGGGGGACTCAAGGAGATTTCACCACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTG
GAGTTCTGGCCCTGGAAGATAAAGAACTGGGAAGGGTGATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTACACCGAATGG
TAGTTCCAAAAAATAGCCAGGATTCTGACTTAAAAATCAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGCATAGTGGATATC
TGTATGCCCTTGGACAGAAGGTTTGGAAAAGATGGAAAAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTTGCTATGTGCA
GTTATAGAGAAAAGAAGTCTGAACCACAAGAATTAATGCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGG
GTGGTTGTATGTTCTTTAATGCTGTTAAAGAAGGAGATACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTATGGGTTCAAG
CCATGTATAGGGCCACAGGTCAATCATATAAACCAGTTCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAG
ATGCTCAGCTTTCTGGTAAAGATGCAGATCGTTTTCAGAAACATGGTATGGATGAGTTTATTTCTGCAAACCCCTGCAAGCTTGATCATG
CCTTCCTTTTTAGAATACTCCAGAGGCAGACTTTGGATCACAGACTGAATGATTCCTATTCTTGCTTGGGATGGTTTAGCCCTGGCCAAG
TCTTTGTGTTAGATGAGTACTGTGCCCGTTATGGTGTGAGAGGCTGTCACAGACATCTCTGCTACCTTGCAGAACTGATGGAACATTCAG
AAAATGGTGCTGTCATTGACCCTACCCTGCTCCATTACAGCTTTGCATTCTGTGCCTCTCATGTGCACGGCAACAGGCCTGATGGAATTG
GGACTGTTTCAGTGGAAGAAAAAGAAAGATTTGAGGAGATAAAAGAGAGACTCTCTTCCCTTTTAGAAAATCAGATAAGCCATTTCAGAT
ACTGTTTTCCCTTTGGACGACCTGAAGGTGCTCTAAAAGCTACACTTTCATTACTTGAAAGGGTTTTAATGAAAGATATTGCCACTCCCA
TACCAGCAGAAGAGGTGAAGAAAGTGGTCAGAAAATGTCTCGAGAAAGCTGCCTTGATCAATTACACTAGACTCACAGAATATGCCAAAA
TAGAAGAGACCATGAACCAGGCATCTCCTGCTAGAAAGCTGGAAGAGATTCTTCATCTGGCAGAGCTCTGCATAGAAGTCTTACAGCAGA
ATGAAGAGCATCATGCAGAGGGAAGAGAGGCATTTGCCTGGTGGCCTGATTTATTGGCTGAACATGCAGAGAAATTTTGGGCTTTATTTA
CAGTGGATATGGACACTGCACTAGAGGCTCAACCGCAAGACTCCTGGGATAGTTTTCCTCTTTTCCAACTGCTTAATAATTTCCTCCGAA
ATGACACACTTTTGTGTAATGGAAAATTTCACAAACACTTGCAAGAAATCTTTGTACCCTTGGTTGTCCGCTATGTGGATCTCATGGAGT
CTTCCATCGCCCAGTCAATTCACAGAGGTTTTGAGCAGGAGACATGGCAGCCTGTCAAGAATATCGCCAACAGTCTTCCCAATGTAGCTC
TTCCAAAAGTTCCAAGTCTGCCTCTTAATCTTCCACAGATTCCTAACATTTCTACTGCTTCGTGGATGCCTTCTTTATATGAGTCCACCA
ATGGCTCAGCAACATCAGAAGACCTTTTTTGGAAGCTTGATGCACTGCAAATGTTTGTCTTTGATCTGCACTGGCCAGAACAGGAATTTG
CCCACCACTTAGAGCAAAGACTTAAACTAATGGCCAGTGATATGCTAGAGGCCTGTGTCAAAAGAACAAGAACTGCATTTGAACTCAAGC
TACAAAAGGCAAGCAAAACAACTGACTTGCGCATTCCAGCTTCCGTTTGCACTATGTTTAATGTATTAGTCGATGCCAAAAAGCAAAGCA
CCAAACTCTGTGCCCTGGATGGAGGACAAGAGCAACAGTACCATTCAAAAATAGATGATCTGATCGACAACAGTGTAAAAGAAATCATTT
CACTGTTAGTTTCAAAGTTTGTTTCAGTGTTGGAAGGCGTGTTGTCTAAGCTGTCAAGGTATGATGAAGGCACTTTCTTTTCATCCATTC
TGTCATTCACTGTGAAAGCAGCTGCAAAATATGTTGATGTTCCAAAACCAGGAATGGATCTGGCAGACACCTATATTATGTTTGTTCGGC
AAAACCAAGATATTCTTCGAGAAAAGGTCAATGAGGAAATGTATATAGAAAAGTTATTTGATCAATGGTACAGCAGTTCCATGAAAGTCA
TTTGCGTGTGGTTGACTGATAGATTAGACCTCCAACTCCATATTTACCAGCTGAAGACGCTCATCAAGATTGTGAAGAAAACCTACAGGG
ACTTTCGATTGCAGGGTGTGTTGGAAGGAACACTGAACAGTAAGACTTATGATACTGTGCACAGACGTTTAACAGTAGAGGAGGCCACAG
CCTCTGTTTCAGAAGGAGGAGGACTTCAGGGCATTACTATGAAAGACAGTGACGAAGAAGAAGAAGGCTGATATCACACAGCTTTGCAGA
AGGAAGGAAGACCTTGATCGACATTGTTTTTTATTTTTTTAACCTTGTCCTTGTAATTACATTCATTGTTTGTTTTGGCCAAATAAAAAT
GCTTGTATTTCTTTAAAAAGTAAGCCTGAATGTAGAGTAAAAGGGGAAATGCC

>22191_22191_4_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000373620_CADPS2_chr7_122377122_ENST00000449022_length(amino acids)=1392AA_BP=209
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFR
EVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLD
NADEQAAQIRRELDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEI
QLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELG
RVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQE
LMQLEGYTVDYTDPHPGLQGGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLSGKDADR
FQKHGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLL
HYSFAFCASHVHGNRPDGIGTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKKVVR
KCLEKAALINYTRLTEYAKIEETMNQASPARKLEEILHLAELCIEVLQQNEEHHAEGREAFAWWPDLLAEHAEKFWALFTVDMDTALEAQ
PQDSWDSFPLFQLLNNFLRNDTLLCNGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQPVKNIANSLPNVALPKVPSLPLNL
PQIPNISTASWMPSLYESTNGSATSEDLFWKLDALQMFVFDLHWPEQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKASKTTDLR
IPASVCTMFNVLVDAKKQSTKLCALDGGQEQQYHSKIDDLIDNSVKEIISLLVSKFVSVLEGVLSKLSRYDEGTFFSSILSFTVKAAAKY
VDVPKPGMDLADTYIMFVRQNQDILREKVNEEMYIEKLFDQWYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTYRDFRLQGVLEGT
LNSKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEEG

--------------------------------------------------------------
>22191_22191_5_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000373624_CADPS2_chr7_122377122_ENST00000313070_length(transcript)=5987nt_BP=820nt
GCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCCAGCCTGA
GGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGCCCGCGGG
CCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATGTTGAAGTGGCCTATCCCAG
GACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTCTACAGACTTTGACCAAGTT
TTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAG
ATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCT
TAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCC
AGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGAC
AGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAA
ACTCAGCACTCTTAACAAACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAACCCAAATTGTAGCTGACGA
AGCATTTTGCAACGCAGTTCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCCAGAATGGTACAGAGTGGAGGGTGTTCTGC
TAATGACTTCAGAGAAGTATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCTTGAGCAAAGAGACAGTGTT
GAGCTCATGGATAGCCAAATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAGCCAAATAGAATGGCCCTAAGTGCAGTGTC
TGAACTTATTCTGAGCAAGGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAACACCAGCTCCTTTATAATGC
ATGTCAGCTGGATAACGCAGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGGCTGCAATTGGCAGATAAAATGGCAAAGGA
AAGAAAATTCCCCAAATTTATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGAATTTGCTAATGGCCAATTT
GGAAAGTCTTCCAGTTTCGAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCACAGAACTCTGCATTTTTGGACATAGGAGA
TGAGAATGAGATTCAGCTGTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAGTGCAAGGCCTGAAGTCAGT
TGCTCCCAATCGAATTGTTTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGACCAGGCCGAAGCCTCAAGGCCACAATGGGG
GACTCAAGGAGATTTCACCACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTGGAGTTCTGGCCCTGGAAGA
TAAAGAACTGGGAAGGGTGATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTACACCGAATGGTAGTTCCAAAAAATAGCCA
GGATTCTGACTTAAAAATCAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGCATAGTGGATATCTGTATGCCCTTGGACAGAA
GGTTTGGAAAAGATGGAAAAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTTGCTATGTGCAGTTATAGAGAAAAGAAGTC
TGAACCACAAGAATTAATGCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGGGTGGTTGTATGTTCTTTAA
TGCTGTTAAAGAAGGAGATACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTATGGGTTCAAGCCATGTATAGGGCCACAGG
TCAATCATATAAACCAGTTCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAGATGCTCAGCTTTATGCAGA
TCGTTTTCAGAAACATGGTATGGATGAGTTTATTTCTGCAAACCCCTGCAAGCTTGATCATGCCTTCCTTTTTAGAATACTCCAGAGGCA
GACTTTGGATCACAGACTGAATGATTCCTATTCTTGCTTGGGATGGTTTAGCCCTGGCCAAGTCTTTGTGTTAGATGAGTACTGTGCCCG
TTATGGTGTGAGAGGCTGTCACAGACATCTCTGCTACCTTGCAGAACTGATGGAACATTCAGAAAATGGTGCTGTCATTGACCCTACCCT
GCTCCATTACAGCTTTGCATTCTGTGCCTCTCATGTGCACGGCAACAGGCCTGATGGAATTGGGACTGTTTCAGTGGAAGAAAAAGAAAG
ATTTGAGGAGATAAAAGAGAGACTCTCTTCCCTTTTAGAAAATCAGATAAGCCATTTCAGATACTGTTTTCCCTTTGGACGACCTGAAGG
TGCTCTAAAAGCTACACTTTCATTACTTGAAAGGGTTTTAATGAAAGATATTGCCACTCCCATACCAGCAGAAGAGGTGAAGAAAGTGGT
CAGAAAATGTCTCGAGAAAGCTGCCTTGATCAATTACACTAGACTCACAGAATATGCCAAAATAGAAGAGACCATGAACCAGGCATCTCC
TGCTAGAAAGCTGGAAGAGATTCTTCATCTGGCAGAGCTCTGCATAGAAGTCTTACAGCAGAATGAAGAGCATCATGCAGAGGCATTTGC
CTGGTGGCCTGATTTATTGGCTGAACATGCAGAGAAATTTTGGGCTTTATTTACAGTGGATATGGACACTGCACTAGAGGCTCAACCGCA
AGACTCCTGGGATAGTTTTCCTCTTTTCCAACTGCTTAATAATTTCCTCCGAAATGACACACTTTTGTGTAATGGAAAATTTCACAAACA
CTTGCAAGAAATCTTTGTACCCTTGGTTGTCCGCTATGTGGATCTCATGGAGTCTTCCATCGCCCAGTCAATTCACAGAGGTTTTGAGCA
GGAGACATGGCAGCCTGTCAACAATGGCTCAGCAACATCAGAAGACCTTTTTTGGAAGCTTGATGCACTGCAAATGTTTGTCTTTGATCT
GCACTGGCCAGAACAGGAATTTGCCCACCACTTAGAGCAAAGACTTAAACTAATGGCCAGTGATATGCTAGAGGCCTGTGTCAAAAGAAC
AAGAACTGCATTTGAACTCAAGCTACAAAAGGCAAGCAAAACAACTGACTTGCGCATTCCAGCTTCCGTTTGCACTATGTTTAATGTATT
AGTCGATGCCAAAAAGCAAAGCACCAAACTCTGTGCCCTGGATGGAGGACAAGAGGTATGTAGAATTTTTCAACAGTACCATTCAAAAAT
AGATGATCTGATCGACAACAGTGTAAAAGAAATCATTTCACTGTTAGTTTCAAAGTTTGTTTCAGTGTTGGAAGGCGTGTTGTCTAAGCT
GTCAAGGTATGATGAAGGCACTTTCTTTTCATCCATTCTGTCATTCACTGTGAAAGCAGCTGCAAAATATGTTGATGTTCCAAAACCAGG
AATGGATCTGGCAGACACCTATATTATGTTTGTTCGGCAAAACCAAGATATTCTTCGAGAAAAGGTCAATGAGGAAATGTATATAGAAAA
GTTATTTGATCAATGGTACAGCAGTTCCATGAAAGTCATTTGCGTGTGGTTGACTGATAGATTAGACCTCCAACTCCATATTTACCAGCT
GAAGACGCTCATCAAGATTGTGAAGAAAACCTACAGGGACTTTCGATTGCAGGGTGTGTTGGAAGGAACACTGAACAGTAAGACTTATGA
TACTGTGCACAGACGTTTAACAGTAGAGGAGGCCACAGCCTCTGTTTCAGAAGGAGGAGGACTTCAGGGCATTACTATGAAAGACAGTGA
CGAAGAAGAAGAAGGCTGATATCACACAGCTTTGCAGAAGGAAGGAAGACCTTGATCGACATTGTTTTTTATTTTTTTAACCTTGTCCTT
GTAATTACATTCATTGTTTGTTTTGGCCAAATAAAAATGCTTGTATTTCTTTAAAAAGTAAGCCTGAATGTAGAGTAAAAGGGGAAATGC
CAAGATTTTGGGGTTTTTTTGTTTCCTTTTTTTGTTTGTTTGTTTGTTTGTTTTTTTGGAGAAGAGCATCCTCTTTTGTGTAGTTTGACC
TAAAAATGAACCTTGGCTCTGCTTGTGATCAGAACATGAACTTTTTTTTTTAAAGAAGATTTGAGCATTTTTCTGTAATCACATCAAAAT
GATGTTTTCTGTGTAAAGCGAGATACATATTTCTCATAATGCAGCATTGTGAGAAGTCAGTTCGGACCACTGCACCAACACTGTCGTATC
CTTGTTAAAATGGTGTGTACCTTACAAATTATAATTTATGTGCCAGGTTCGTTTTGTACTTAATTTGCTATTATTGTGATGTGTATAAAA
TCTTTAATCTTGGTTCTTAGTACTTTGAATTGGTCTACAGGTATATTCCTGGGATGAAAGGATTGCCAAACCCAAATATAGACTAGATTA
TCCAATGGGTTTGTGTCTTTGTTCCATTCTCAACATTTCTTCTTTCAACTATAAGTAATCCCCAGGTGTGGGGTAGCAAGTGTGCTTCCG
TCAAGATACCATATTCTCCTGCTCCAGTATAACAGCTTGCAGGCAATAAAAATCTATTTGCTCATAACTACTTCTGTATTTATTAGACTT
ATATAGAGCAAATGCAGTAAAAGAGGTTTGCAGTGTTTCAAACATCCCAACTATCTGACTCTGTGTTTTTGTTTCTTGAGTTTTTTGTTT
GTTTTGTTTGTAATATTTTGTTTTTAATCAAATGAGTAAAAGATAGTAACACTGACTGTTCTTTGTACCTAATAGGCACATACATTGTTA
AAAGAATTACTATGACAGCATATTTCCATAGCAGAGGAAATATATATTTCATATATTATTAGTTAATATTAGTAATCAATGTTAACTAAT
AATTAGTAATGTTAGTAATATTAACTAGTAATTCACATTATTAGTGGTTCTCTCAAAATATTTTCTTGCTAGGGTTTGAGAGATAATTGT
ATTATGTTGCGTAAGTTCTCTATGAATTATTTTTGTGATATTTCCCAAAACATATTGGCAGATTGTGCTACTGCATTTATTAATAAGTAA
TTTTTAAATGAAGGCAGTTAATGCAGAATAAGTGGAGGTATCCCTGCATTTATGAAAACGTTTATTCTGAAACTTTAGAAATGAAACAAC
TTGGACCTCCAGATTCGTTCTCCCATGGTGTAATAAGTGGTCGTTAGGTACCTAGACTAGCCTTAAAAATCTATTTAATCTACAGTTACT
ATTTAGCATTGTTTTGGCTCATTTTCTGGGCCCTAGGGCTAAGATAACAAACAAGGAAATTTCTTCCTTCTTCCGGGATTAAAGACTAAC
TCTACCAACTCACTATCTTTGAAAGGCAGTTTGGGAATGTTCTCCCTCCTTTTCTTCTCTATTCACACACCAAATACTATTTTCTCCAAA
CCCTCAAATGTCCAGTCATGCTATCCCAAACTCTCCAATGGCACCATCCCCAAGCTTGCTGTTCCACGACACATTGCTCTGTACTTAGTA
ATTACCCACCCTTCTTTTCCTTTCAATAAAATGTCCATTTCCTTGAT

>22191_22191_5_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000373624_CADPS2_chr7_122377122_ENST00000313070_length(amino acids)=1351AA_BP=209
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFR
EVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLD
NADEQAAQIRRELDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEI
QLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELG
RVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQE
LMQLEGYTVDYTDPHPGLQGGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLYADRFQK
HGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYS
FAFCASHVHGNRPDGIGTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKKVVRKCL
EKAALINYTRLTEYAKIEETMNQASPARKLEEILHLAELCIEVLQQNEEHHAEAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWD
SFPLFQLLNNFLRNDTLLCNGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQPVNNGSATSEDLFWKLDALQMFVFDLHWPE
QEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKASKTTDLRIPASVCTMFNVLVDAKKQSTKLCALDGGQEVCRIFQQYHSKIDDLI
DNSVKEIISLLVSKFVSVLEGVLSKLSRYDEGTFFSSILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQDILREKVNEEMYIEKLFDQ
WYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTYRDFRLQGVLEGTLNSKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEE
G

--------------------------------------------------------------
>22191_22191_6_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000373624_CADPS2_chr7_122377122_ENST00000334010_length(transcript)=6104nt_BP=820nt
GCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCCAGCCTGA
GGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGCCCGCGGG
CCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATGTTGAAGTGGCCTATCCCAG
GACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTCTACAGACTTTGACCAAGTT
TTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAG
ATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCT
TAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCC
AGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGAC
AGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAA
ACTCAGCACTCTTAACAAACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAACCCAAATTGTAGCTGACGA
AGCATTTTGCAACGCAGTTCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCCAGAATGGTACAGAGTGGAGGGTGTTCTGC
TAATGACTTCAGAGAAGTATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCTTGAGCAAAGAGACAGTGTT
GAGCTCATGGATAGCCAAATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAGCCAAATAGAATGGCCCTAAGTGCAGTGTC
TGAACTTATTCTGAGCAAGGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAACACCAGCTCCTTTATAATGC
ATGTCAGCTGGATAACGCAGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGGCTGCAATTGGCAGATAAAATGGCAAAGGA
AAGAAAATTCCCCAAATTTATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGAATTTGCTAATGGCCAATTT
GGAAAGTCTTCCAGTTTCGAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCACAGAACTCTGCATTTTTGGACATAGGAGA
TGAGAATGAGATTCAGCTGTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAGTGCAAGGCCTGAAGTCAGT
TGCTCCCAATCGAATTGTTTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGACCAGGCCGAAGCCTCAAGGCCACAATGGGG
GACTCAAGGAGATTTCACCACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTGGAGTTCTGGCCCTGGAAGA
TAAAGAACTGGGAAGGGTGATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTACACCGAATGGTAGTTCCAAAAAATAGCCA
GGATTCTGACTTAAAAATCAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGCATAGTGGATATCTGTATGCCCTTGGACAGAA
GGTTTGGAAAAGATGGAAAAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTTGCTATGTGCAGTTATAGAGAAAAGAAGTC
TGAACCACAAGAATTAATGCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGGGTGGTTGTATGTTCTTTAA
TGCTGTTAAAGAAGGAGATACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTATGGGTTCAAGCCATGTATAGGGCCACAGG
TCAATCATATAAACCAGTTCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAGATGCTCAGCTTTCTGAATT
TACAGATGCAGATCGTTTTCAGAAACATGGTATGGATGAGTTTATTTCTGCAAACCCCTGCAAGCTTGATCATGCCTTCCTTTTTAGAAT
ACTCCAGAGGCAGACTTTGGATCACAGACTGAATGATTCCTATTCTTGCTTGGGATGGTTTAGCCCTGGCCAAGTCTTTGTGTTAGATGA
GTACTGTGCCCGTTATGGTGTGAGAGGCTGTCACAGACATCTCTGCTACCTTGCAGAACTGATGGAACATTCAGAAAATGGTGCTGTCAT
TGACCCTACCCTGCTCCATTACAGCTTTGCATTCTGTGCCTCTCATGTGCACGGCAACAGGCCTGATGGAATTGGGACTGTTTCAGTGGA
AGAAAAAGAAAGATTTGAGGAGATAAAAGAGAGACTCTCTTCCCTTTTAGAAAATCAGATAAGCCATTTCAGATACTGTTTTCCCTTTGG
ACGACCTGAAGGTGCTCTAAAAGCTACACTTTCATTACTTGAAAGGGTTTTAATGAAAGATATTGCCACTCCCATACCAGCAGAAGAGGT
GAAGAAAGTGGTCAGAAAATGTCTCGAGAAAGCTGCCTTGATCAATTACACTAGACTCACAGAATATGCCAAAATAGAAGAGACCATGAA
CCAGGCATCTCCTGCTAGAAAGCTGGAAGAGATTCTTCATCTGGCAGAGCTCTGCATAGAAGTCTTACAGCAGAATGAAGAGCATCATGC
AGAGGCATTTGCCTGGTGGCCTGATTTATTGGCTGAACATGCAGAGAAATTTTGGGCTTTATTTACAGTGGATATGGACACTGCACTAGA
GGCTCAACCGCAAGACTCCTGGGATAGTTTTCCTCTTTTCCAACTGCTTAATAATTTCCTCCGAAATGACACACTTTTGTGTAATGGAAA
ATTTCACAAACACTTGCAAGAAATCTTTGTACCCTTGGTTGTCCGCTATGTGGATCTCATGGAGTCTTCCATCGCCCAGTCAATTCACAG
AGGTTTTGAGCAGGAGACATGGCAGCCTGTCAAGAATATCGCCAACAGTCTTCCCAATGTAGCTCTTCCAAAAGTTCCAAGTCTGCCTCT
TAATCTTCCACAGATTCCTAACATTTCTACTGCTTCGTGGATGCCTTCTTTATATGAGTCCACCAATGGCTCAGCAACATCAGAAGACCT
TTTTTGGAAGCTTGATGCACTGCAAATGTTTGTCTTTGATCTGCACTGGCCAGAACAGGAATTTGCCCACCACTTAGAGCAAAGACTTAA
ACTAATGGCCAGTGATATGCTAGAGGCCTGTGTCAAAAGAACAAGAACTGCATTTGAACTCAAGCTACAAAAGGCAAGCAAAACAACTGA
CTTGCGCATTCCAGCTTCCGTTTGCACTATGTTTAATGTATTAGTCGATGCCAAAAAGCAAAGCACCAAACTCTGTGCCCTGGATGGAGG
ACAAGAGCAACAGTACCATTCAAAAATAGATGATCTGATCGACAACAGTGTAAAAGAAATCATTTCACTGTTAGTTTCAAAGTTTGTTTC
AGTGTTGGAAGGCGTGTTGTCTAAGCTGTCAAGGTATGATGAAGGCACTTTCTTTTCATCCATTCTGTCATTCACTGTGAAAGCAGCTGC
AAAATATGTTGATGTTCCAAAACCAGGAATGGATCTGGCAGACACCTATATTATGTTTGTTCGGCAAAACCAAGATATTCTTCGAGAAAA
GGTCAATGAGGAAATGTATATAGAAAAGTTATTTGATCAATGGTACAGCAGTTCCATGAAAGTCATTTGCGTGTGGTTGACTGATAGATT
AGACCTCCAACTCCATATTTACCAGCTGAAGACGCTCATCAAGATTGTGAAGAAAACCTACAGGGACTTTCGATTGCAGGGTGTGTTGGA
AGGAACACTGAACAGTAAGACTTATGATACTGTGCACAGACGTTTAACAGTAGAGGAGGCCACAGCCTCTGTTTCAGAAGGAGGAGGACT
TCAGGGCATTACTATGAAAGACAGTGACGAAGAAGAAGAAGGCTGATATCACACAGCTTTGCAGAAGGAAGGAAGACCTTGATCGACATT
GTTTTTTATTTTTTTAACCTTGTCCTTGTAATTACATTCATTGTTTGTTTTGGCCAAATAAAAATGCTTGTATTTCTTTAAAAAGTAAGC
CTGAATGTAGAGTAAAAGGGGAAATGCCAAGATTTTGGGGTTTTTTTGTTTCCTTTTTTTGTTTGTTTGTTTGTTTGTTTTTTTGGAGAA
GAGCATCCTCTTTTGTGTAGTTTGACCTAAAAATGAACCTTGGCTCTGCTTGTGATCAGAACATGAACTTTTTTTTTTAAAGAAGATTTG
AGCATTTTTCTGTAATCACATCAAAATGATGTTTTCTGTGTAAAGCGAGATACATATTTCTCATAATGCAGCATTGTGAGAAGTCAGTTC
GGACCACTGCACCAACACTGTCGTATCCTTGTTAAAATGGTGTGTACCTTACAAATTATAATTTATGTGCCAGGTTCGTTTTGTACTTAA
TTTGCTATTATTGTGATGTGTATAAAATCTTTAATCTTGGTTCTTAGTACTTTGAATTGGTCTACAGGTATATTCCTGGGATGAAAGGAT
TGCCAAACCCAAATATAGACTAGATTATCCAATGGGTTTGTGTCTTTGTTCCATTCTCAACATTTCTTCTTTCAACTATAAGTAATCCCC
AGGTGTGGGGTAGCAAGTGTGCTTCCGTCAAGATACCATATTCTCCTGCTCCAGTATAACAGCTTGCAGGCAATAAAAATCTATTTGCTC
ATAACTACTTCTGTATTTATTAGACTTATATAGAGCAAATGCAGTAAAAGAGGTTTGCAGTGTTTCAAACATCCCAACTATCTGACTCTG
TGTTTTTGTTTCTTGAGTTTTTTGTTTGTTTTGTTTGTAATATTTTGTTTTTAATCAAATGAGTAAAAGATAGTAACACTGACTGTTCTT
TGTACCTAATAGGCACATACATTGTTAAAAGAATTACTATGACAGCATATTTCCATAGCAGAGGAAATATATATTTCATATATTATTAGT
TAATATTAGTAATCAATGTTAACTAATAATTAGTAATGTTAGTAATATTAACTAGTAATTCACATTATTAGTGGTTCTCTCAAAATATTT
TCTTGCTAGGGTTTGAGAGATAATTGTATTATGTTGCGTAAGTTCTCTATGAATTATTTTTGTGATATTTCCCAAAACATATTGGCAGAT
TGTGCTACTGCATTTATTAATAAGTAATTTTTAAATGAAGGCAGTTAATGCAGAATAAGTGGAGGTATCCCTGCATTTATGAAAACGTTT
ATTCTGAAACTTTAGAAATGAAACAACTTGGACCTCCAGATTCGTTCTCCCATGGTGTAATAAGTGGTCGTTAGGTACCTAGACTAGCCT
TAAAAATCTATTTAATCTACAGTTACTATTTAGCATTGTTTTGGCTCATTTTCTGGGCCCTAGGGCTAAGATAACAAACAAGGAAATTTC
TTCCTTCTTCCGGGATTAAAGACTAACTCTACCAACTCACTATCTTTGAAAGGCAGTTTGGGAATGTTCTCCCTCCTTTTCTTCTCTATT
CACACACCAAATACTATTTTCTCCAAACCCTCAAATGTCCAGTCATGCTATCCCAAACTCTCCAATGGCACCATCCCCAAGCTTGCTGTT
CCACGACACATTGCTCTGTACTTAGTAATTACCCACCCTTCTTTTCCTTTCAATAAAATGTCCATTTCCTTGAT

>22191_22191_6_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000373624_CADPS2_chr7_122377122_ENST00000334010_length(amino acids)=1390AA_BP=209
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFR
EVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLD
NADEQAAQIRRELDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEI
QLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELG
RVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQE
LMQLEGYTVDYTDPHPGLQGGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLSEFTDAD
RFQKHGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTL
LHYSFAFCASHVHGNRPDGIGTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKKVV
RKCLEKAALINYTRLTEYAKIEETMNQASPARKLEEILHLAELCIEVLQQNEEHHAEAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQ
DSWDSFPLFQLLNNFLRNDTLLCNGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQPVKNIANSLPNVALPKVPSLPLNLPQ
IPNISTASWMPSLYESTNGSATSEDLFWKLDALQMFVFDLHWPEQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKASKTTDLRIP
ASVCTMFNVLVDAKKQSTKLCALDGGQEQQYHSKIDDLIDNSVKEIISLLVSKFVSVLEGVLSKLSRYDEGTFFSSILSFTVKAAAKYVD
VPKPGMDLADTYIMFVRQNQDILREKVNEEMYIEKLFDQWYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTYRDFRLQGVLEGTLN
SKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEEG

--------------------------------------------------------------
>22191_22191_7_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000373624_CADPS2_chr7_122377122_ENST00000412584_length(transcript)=4668nt_BP=820nt
GCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCCAGCCTGA
GGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGCCCGCGGG
CCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATGTTGAAGTGGCCTATCCCAG
GACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTCTACAGACTTTGACCAAGTT
TTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAG
ATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCT
TAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCC
AGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGAC
AGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAA
ACTCAGCACTCTTAACAAACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAACCCAAATTGTAGCTGACGA
AGCATTTTGCAACGCAGTTCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCCAGAATGGTACAGAGTGGAGGGTGTTCTGC
TAATGACTTCAGAGAAGTATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCTTGAGCAAAGAGACAGTGTT
GAGCTCATGGATAGCCAAATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAGCCAAATAGAATGGCCCTAAGTGCAGTGTC
TGAACTTATTCTGAGCAAGGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAACACCAGCTCCTTTATAATGC
ATGTCAGCTGGATAACGCAGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGGCTGCAATTGGCAGATAAAATGGCAAAGGA
AAGAAAATTCCCCAAATTTATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGAATTTGCTAATGGCCAATTT
GGAAAGTCTTCCAGTTTCGAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCACAGAACTCTGCATTTTTGGACATAGGAGA
TGAGAATGAGATTCAGCTGTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAGTGCAAGGCCTGAAGTCAGT
TGCTCCCAATCGAATTGTTTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGACCAGGCCGAAGCCTCAAGGCCACAATGGGG
GACTCAAGGAGATTTCACCACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTGGAGTTCTGGCCCTGGAAGA
TAAAGAACTGGGAAGGGTGATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTACACCGAATGGTAGTTCCAAAAAATAGCCA
GGATTCTGACTTAAAAATCAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGCATAGTGGATATCTGTATGCCCTTGGACAGAA
GGTTTGGAAAAGATGGAAAAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTTGCTATGTGCAGTTATAGAGAAAAGAAGTC
TGAACCACAAGAATTAATGCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGGGTGGTTGTATGTTCTTTAA
TGCTGTTAAAGAAGGAGATACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTATGGGTTCAAGCCATGTATAGGGCCACAGG
TCAATCATATAAACCAGTTCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAGATGCTCAGCTTTATGCAGA
TCGTTTTCAGAAACATGGTATGGATGAGTTTATTTCTGCAAACCCCTGCAAGCTTGATCATGCCTTCCTTTTTAGAATACTCCAGAGGCA
GACTTTGGATCACAGACTGAATGATTCCTATTCTTGCTTGGGATGGTTTAGCCCTGGCCAAGTCTTTGTGTTAGATGAGTACTGTGCCCG
TTATGGTGTGAGAGGCTGTCACAGACATCTCTGCTACCTTGCAGAACTGATGGAACATTCAGAAAATGGTGCTGTCATTGACCCTACCCT
GCTCCATTACAGCTTTGCATTCTGTGCCTCTCATGTGCACGGCAACAGGCCTGATGGAATTGGGACTGTTTCAGTGGAAGAAAAAGAAAG
ATTTGAGGAGATAAAAGAGAGACTCTCTTCCCTTTTAGAAAATCAGATAAGCCATTTCAGATACTGTTTTCCCTTTGGACGACCTGAAGG
TGCTCTAAAAGCTACACTTTCATTACTTGAAAGGGTTTTAATGAAAGATATTGCCACTCCCATACCAGCAGAAGAGGTGAAGAAAGTGGT
CAGAAAATGTCTCGAGAAAGCTGCCTTGATCAATTACACTAGACTCACAGAATATGCCAAAATAGAAGAGACCATGAACCAGGCATCTCC
TGCTAGAAAGCTGGAAGAGATTCTTCATCTGGCAGAGCTCTGCATAGAAGTCTTACAGCAGAATGAAGAGCATCATGCAGAGGCATTTGC
CTGGTGGCCTGATTTATTGGCTGAACATGCAGAGAAATTTTGGGCTTTATTTACAGTGGATATGGACACTGCACTAGAGGCTCAACCGCA
AGACTCCTGGGATAGTTTTCCTCTTTTCCAACTGCTTAATAATTTCCTCCGAAATGACACACTTTTGTGTAATGGAAAATTTCACAAACA
CTTGCAAGAAATCTTTGTACCCTTGGTTGTCCGCTATGTGGATCTCATGGAGTCTTCCATCGCCCAGTCAATTCACAGAGGTTTTGAGCA
GGAGACATGGCAGCCTGTCAACAATGGCTCAGCAACATCAGAAGACCTTTTTTGGAAGCTTGATGCACTGCAAATGTTTGTCTTTGATCT
GCACTGGCCAGAACAGGAATTTGCCCACCACTTAGAGCAAAGACTTAAACTAATGGCCAGTGATATGCTAGAGGCCTGTGTCAAAAGAAC
AAGAACTGCATTTGAACTCAAGCTACAAAAGGCAAGCAAAACAACTGACTTGCGCATTCCAGCTTCCGTTTGCACTATGTTTAATGTATT
AGTCGATGCCAAAAAGCAAAGCACCAAACTCTGTGCCCTGGATGGAGGACAAGAGTTTGGTAGTCAATGGCAACAGTACCATTCAAAAAT
AGATGATCTGATCGACAACAGTGTAAAAGAAATCATTTCACTGTTAGTTTCAAAGTTTGTTTCAGTGTTGGAAGGCGTGTTGTCTAAGCT
GTCAAGGTATGATGAAGGCACTTTCTTTTCATCCATTCTGTCATTCACTGTGAAAGCAGCTGCAAAATATGTTGATGTTCCAAAACCAGG
AATGGATCTGGCAGACACCTATATTATGTTTGTTCGGCAAAACCAAGATATTCTTCGAGAAAAGGTCAATGAGGAAATGTATATAGAAAA
GTTATTTGATCAATGGTACAGCAGTTCCATGAAAGTCATTTGCGTGTGGTTGACTGATAGATTAGACCTCCAACTCCATATTTACCAGCT
GAAGACGCTCATCAAGATTGTGAAGAAAACCTACAGGGACTTTCGATTGCAGGGTGTGTTGGAAGGAACACTGAACAGTAAGACTTATGA
TACTGTGCACAGACGTTTAACAGTAGAGGAGGCCACAGCCTCTGTTTCAGAAGGAGGAGGACTTCAGGGCATTACTATGAAAGACAGTGA
CGAAGAAGAAGAAGGCTGATATCACACAGCTTTGCAGAAGGAAGGAAGACCTTGATCGACATTGTTTTTTATTTTTTTAACCTTGTCCTT
GTAATTACATTCATTGTTTGTTTTGGCCAAATAAAAATGCTTGTATTTCTTTAAAAAGTAAGCCTGAATGTAGAGTAAAAGGGGAAATGC
CAAGATTTTGGGGTTTTTTTGTTTCCTTTTTTTGTTTGTTTGTTTGTTTGTTTTTTTGGAGAAGAGCATCCTCTTTTGTGTAGTTTGACC
TAAAAATGAACCTTGGCTCTGCTTGTGATCAGAACATGAACTTTTTTTTTTAAAGAAGATTTGAGCATTTTTCTGTAATCACATCAAAAT
GATGTTTTCTGTGTAAAGCGAGATACATATTTCTCATAATGCAGCATTGTGAGAAGTCAGTTCGGACCACTGCACCAA

>22191_22191_7_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000373624_CADPS2_chr7_122377122_ENST00000412584_length(amino acids)=1351AA_BP=209
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFR
EVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLD
NADEQAAQIRRELDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEI
QLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELG
RVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQE
LMQLEGYTVDYTDPHPGLQGGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLYADRFQK
HGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYS
FAFCASHVHGNRPDGIGTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKKVVRKCL
EKAALINYTRLTEYAKIEETMNQASPARKLEEILHLAELCIEVLQQNEEHHAEAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWD
SFPLFQLLNNFLRNDTLLCNGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQPVNNGSATSEDLFWKLDALQMFVFDLHWPE
QEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKASKTTDLRIPASVCTMFNVLVDAKKQSTKLCALDGGQEFGSQWQQYHSKIDDLI
DNSVKEIISLLVSKFVSVLEGVLSKLSRYDEGTFFSSILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQDILREKVNEEMYIEKLFDQ
WYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTYRDFRLQGVLEGTLNSKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEE
G

--------------------------------------------------------------
>22191_22191_8_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000373624_CADPS2_chr7_122377122_ENST00000449022_length(transcript)=4534nt_BP=820nt
GCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCCAGCCTGA
GGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGCCCGCGGG
CCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATGTTGAAGTGGCCTATCCCAG
GACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTCTACAGACTTTGACCAAGTT
TTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAG
ATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCT
TAACATCCTGGCAGATTACACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCC
AGGAGTGTCTGTCCATCTCAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGAC
AGAATATTTTGTGGCTGTGGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAA
ACTCAGCACTCTTAACAAACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAACCCAAATTGTAGCTGACGA
AGCATTTTGCAACGCAGTTCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCCAGAATGGTACAGAGTGGAGGGTGTTCTGC
TAATGACTTCAGAGAAGTATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCTTGAGCAAAGAGACAGTGTT
GAGCTCATGGATAGCCAAATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAGCCAAATAGAATGGCCCTAAGTGCAGTGTC
TGAACTTATTCTGAGCAAGGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAACACCAGCTCCTTTATAATGC
ATGTCAGCTGGATAACGCAGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGGCTGCAATTGGCAGATAAAATGGCAAAGGA
AAGAAAATTCCCCAAATTTATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGAATTTGCTAATGGCCAATTT
GGAAAGTCTTCCAGTTTCGAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCACAGAACTCTGCATTTTTGGACATAGGAGA
TGAGAATGAGATTCAGCTGTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAGTGCAAGGCCTGAAGTCAGT
TGCTCCCAATCGAATTGTTTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGACCAGGCCGAAGCCTCAAGGCCACAATGGGG
GACTCAAGGAGATTTCACCACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTGGAGTTCTGGCCCTGGAAGA
TAAAGAACTGGGAAGGGTGATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTACACCGAATGGTAGTTCCAAAAAATAGCCA
GGATTCTGACTTAAAAATCAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGCATAGTGGATATCTGTATGCCCTTGGACAGAA
GGTTTGGAAAAGATGGAAAAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTTGCTATGTGCAGTTATAGAGAAAAGAAGTC
TGAACCACAAGAATTAATGCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGGGTGGTTGTATGTTCTTTAA
TGCTGTTAAAGAAGGAGATACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTATGGGTTCAAGCCATGTATAGGGCCACAGG
TCAATCATATAAACCAGTTCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAGATGCTCAGCTTTCTGGTAA
AGATGCAGATCGTTTTCAGAAACATGGTATGGATGAGTTTATTTCTGCAAACCCCTGCAAGCTTGATCATGCCTTCCTTTTTAGAATACT
CCAGAGGCAGACTTTGGATCACAGACTGAATGATTCCTATTCTTGCTTGGGATGGTTTAGCCCTGGCCAAGTCTTTGTGTTAGATGAGTA
CTGTGCCCGTTATGGTGTGAGAGGCTGTCACAGACATCTCTGCTACCTTGCAGAACTGATGGAACATTCAGAAAATGGTGCTGTCATTGA
CCCTACCCTGCTCCATTACAGCTTTGCATTCTGTGCCTCTCATGTGCACGGCAACAGGCCTGATGGAATTGGGACTGTTTCAGTGGAAGA
AAAAGAAAGATTTGAGGAGATAAAAGAGAGACTCTCTTCCCTTTTAGAAAATCAGATAAGCCATTTCAGATACTGTTTTCCCTTTGGACG
ACCTGAAGGTGCTCTAAAAGCTACACTTTCATTACTTGAAAGGGTTTTAATGAAAGATATTGCCACTCCCATACCAGCAGAAGAGGTGAA
GAAAGTGGTCAGAAAATGTCTCGAGAAAGCTGCCTTGATCAATTACACTAGACTCACAGAATATGCCAAAATAGAAGAGACCATGAACCA
GGCATCTCCTGCTAGAAAGCTGGAAGAGATTCTTCATCTGGCAGAGCTCTGCATAGAAGTCTTACAGCAGAATGAAGAGCATCATGCAGA
GGGAAGAGAGGCATTTGCCTGGTGGCCTGATTTATTGGCTGAACATGCAGAGAAATTTTGGGCTTTATTTACAGTGGATATGGACACTGC
ACTAGAGGCTCAACCGCAAGACTCCTGGGATAGTTTTCCTCTTTTCCAACTGCTTAATAATTTCCTCCGAAATGACACACTTTTGTGTAA
TGGAAAATTTCACAAACACTTGCAAGAAATCTTTGTACCCTTGGTTGTCCGCTATGTGGATCTCATGGAGTCTTCCATCGCCCAGTCAAT
TCACAGAGGTTTTGAGCAGGAGACATGGCAGCCTGTCAAGAATATCGCCAACAGTCTTCCCAATGTAGCTCTTCCAAAAGTTCCAAGTCT
GCCTCTTAATCTTCCACAGATTCCTAACATTTCTACTGCTTCGTGGATGCCTTCTTTATATGAGTCCACCAATGGCTCAGCAACATCAGA
AGACCTTTTTTGGAAGCTTGATGCACTGCAAATGTTTGTCTTTGATCTGCACTGGCCAGAACAGGAATTTGCCCACCACTTAGAGCAAAG
ACTTAAACTAATGGCCAGTGATATGCTAGAGGCCTGTGTCAAAAGAACAAGAACTGCATTTGAACTCAAGCTACAAAAGGCAAGCAAAAC
AACTGACTTGCGCATTCCAGCTTCCGTTTGCACTATGTTTAATGTATTAGTCGATGCCAAAAAGCAAAGCACCAAACTCTGTGCCCTGGA
TGGAGGACAAGAGCAACAGTACCATTCAAAAATAGATGATCTGATCGACAACAGTGTAAAAGAAATCATTTCACTGTTAGTTTCAAAGTT
TGTTTCAGTGTTGGAAGGCGTGTTGTCTAAGCTGTCAAGGTATGATGAAGGCACTTTCTTTTCATCCATTCTGTCATTCACTGTGAAAGC
AGCTGCAAAATATGTTGATGTTCCAAAACCAGGAATGGATCTGGCAGACACCTATATTATGTTTGTTCGGCAAAACCAAGATATTCTTCG
AGAAAAGGTCAATGAGGAAATGTATATAGAAAAGTTATTTGATCAATGGTACAGCAGTTCCATGAAAGTCATTTGCGTGTGGTTGACTGA
TAGATTAGACCTCCAACTCCATATTTACCAGCTGAAGACGCTCATCAAGATTGTGAAGAAAACCTACAGGGACTTTCGATTGCAGGGTGT
GTTGGAAGGAACACTGAACAGTAAGACTTATGATACTGTGCACAGACGTTTAACAGTAGAGGAGGCCACAGCCTCTGTTTCAGAAGGAGG
AGGACTTCAGGGCATTACTATGAAAGACAGTGACGAAGAAGAAGAAGGCTGATATCACACAGCTTTGCAGAAGGAAGGAAGACCTTGATC
GACATTGTTTTTTATTTTTTTAACCTTGTCCTTGTAATTACATTCATTGTTTGTTTTGGCCAAATAAAAATGCTTGTATTTCTTTAAAAA
GTAAGCCTGAATGTAGAGTAAAAGGGGAAATGCC

>22191_22191_8_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000373624_CADPS2_chr7_122377122_ENST00000449022_length(amino acids)=1392AA_BP=209
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFR
EVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLD
NADEQAAQIRRELDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEI
QLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELG
RVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQE
LMQLEGYTVDYTDPHPGLQGGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLSGKDADR
FQKHGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLL
HYSFAFCASHVHGNRPDGIGTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKKVVR
KCLEKAALINYTRLTEYAKIEETMNQASPARKLEEILHLAELCIEVLQQNEEHHAEGREAFAWWPDLLAEHAEKFWALFTVDMDTALEAQ
PQDSWDSFPLFQLLNNFLRNDTLLCNGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQPVKNIANSLPNVALPKVPSLPLNL
PQIPNISTASWMPSLYESTNGSATSEDLFWKLDALQMFVFDLHWPEQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKASKTTDLR
IPASVCTMFNVLVDAKKQSTKLCALDGGQEQQYHSKIDDLIDNSVKEIISLLVSKFVSVLEGVLSKLSRYDEGTFFSSILSFTVKAAAKY
VDVPKPGMDLADTYIMFVRQNQDILREKVNEEMYIEKLFDQWYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTYRDFRLQGVLEGT
LNSKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEEG

--------------------------------------------------------------
>22191_22191_9_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000394219_CADPS2_chr7_122377122_ENST00000313070_length(transcript)=5879nt_BP=712nt
GACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCC
AGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGC
CCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGAAGTTCTACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGT
GGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTT
ATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTA
CACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCT
CAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGT
GGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAAACTCAGCACTCTTAACAA
ACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAACCCAAATTGTAGCTGACGAAGCATTTTGCAACGCAGT
TCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCCAGAATGGTACAGAGTGGAGGGTGTTCTGCTAATGACTTCAGAGAAGT
ATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCTTGAGCAAAGAGACAGTGTTGAGCTCATGGATAGCCAA
ATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAGCCAAATAGAATGGCCCTAAGTGCAGTGTCTGAACTTATTCTGAGCAA
GGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAACACCAGCTCCTTTATAATGCATGTCAGCTGGATAACGC
AGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGGCTGCAATTGGCAGATAAAATGGCAAAGGAAAGAAAATTCCCCAAATT
TATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGAATTTGCTAATGGCCAATTTGGAAAGTCTTCCAGTTTC
GAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCACAGAACTCTGCATTTTTGGACATAGGAGATGAGAATGAGATTCAGCT
GTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAGTGCAAGGCCTGAAGTCAGTTGCTCCCAATCGAATTGT
TTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGACCAGGCCGAAGCCTCAAGGCCACAATGGGGGACTCAAGGAGATTTCAC
CACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTGGAGTTCTGGCCCTGGAAGATAAAGAACTGGGAAGGGT
GATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTACACCGAATGGTAGTTCCAAAAAATAGCCAGGATTCTGACTTAAAAAT
CAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGCATAGTGGATATCTGTATGCCCTTGGACAGAAGGTTTGGAAAAGATGGAA
AAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTTGCTATGTGCAGTTATAGAGAAAAGAAGTCTGAACCACAAGAATTAAT
GCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGGGTGGTTGTATGTTCTTTAATGCTGTTAAAGAAGGAGA
TACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTATGGGTTCAAGCCATGTATAGGGCCACAGGTCAATCATATAAACCAGT
TCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAGATGCTCAGCTTTATGCAGATCGTTTTCAGAAACATGG
TATGGATGAGTTTATTTCTGCAAACCCCTGCAAGCTTGATCATGCCTTCCTTTTTAGAATACTCCAGAGGCAGACTTTGGATCACAGACT
GAATGATTCCTATTCTTGCTTGGGATGGTTTAGCCCTGGCCAAGTCTTTGTGTTAGATGAGTACTGTGCCCGTTATGGTGTGAGAGGCTG
TCACAGACATCTCTGCTACCTTGCAGAACTGATGGAACATTCAGAAAATGGTGCTGTCATTGACCCTACCCTGCTCCATTACAGCTTTGC
ATTCTGTGCCTCTCATGTGCACGGCAACAGGCCTGATGGAATTGGGACTGTTTCAGTGGAAGAAAAAGAAAGATTTGAGGAGATAAAAGA
GAGACTCTCTTCCCTTTTAGAAAATCAGATAAGCCATTTCAGATACTGTTTTCCCTTTGGACGACCTGAAGGTGCTCTAAAAGCTACACT
TTCATTACTTGAAAGGGTTTTAATGAAAGATATTGCCACTCCCATACCAGCAGAAGAGGTGAAGAAAGTGGTCAGAAAATGTCTCGAGAA
AGCTGCCTTGATCAATTACACTAGACTCACAGAATATGCCAAAATAGAAGAGACCATGAACCAGGCATCTCCTGCTAGAAAGCTGGAAGA
GATTCTTCATCTGGCAGAGCTCTGCATAGAAGTCTTACAGCAGAATGAAGAGCATCATGCAGAGGCATTTGCCTGGTGGCCTGATTTATT
GGCTGAACATGCAGAGAAATTTTGGGCTTTATTTACAGTGGATATGGACACTGCACTAGAGGCTCAACCGCAAGACTCCTGGGATAGTTT
TCCTCTTTTCCAACTGCTTAATAATTTCCTCCGAAATGACACACTTTTGTGTAATGGAAAATTTCACAAACACTTGCAAGAAATCTTTGT
ACCCTTGGTTGTCCGCTATGTGGATCTCATGGAGTCTTCCATCGCCCAGTCAATTCACAGAGGTTTTGAGCAGGAGACATGGCAGCCTGT
CAACAATGGCTCAGCAACATCAGAAGACCTTTTTTGGAAGCTTGATGCACTGCAAATGTTTGTCTTTGATCTGCACTGGCCAGAACAGGA
ATTTGCCCACCACTTAGAGCAAAGACTTAAACTAATGGCCAGTGATATGCTAGAGGCCTGTGTCAAAAGAACAAGAACTGCATTTGAACT
CAAGCTACAAAAGGCAAGCAAAACAACTGACTTGCGCATTCCAGCTTCCGTTTGCACTATGTTTAATGTATTAGTCGATGCCAAAAAGCA
AAGCACCAAACTCTGTGCCCTGGATGGAGGACAAGAGGTATGTAGAATTTTTCAACAGTACCATTCAAAAATAGATGATCTGATCGACAA
CAGTGTAAAAGAAATCATTTCACTGTTAGTTTCAAAGTTTGTTTCAGTGTTGGAAGGCGTGTTGTCTAAGCTGTCAAGGTATGATGAAGG
CACTTTCTTTTCATCCATTCTGTCATTCACTGTGAAAGCAGCTGCAAAATATGTTGATGTTCCAAAACCAGGAATGGATCTGGCAGACAC
CTATATTATGTTTGTTCGGCAAAACCAAGATATTCTTCGAGAAAAGGTCAATGAGGAAATGTATATAGAAAAGTTATTTGATCAATGGTA
CAGCAGTTCCATGAAAGTCATTTGCGTGTGGTTGACTGATAGATTAGACCTCCAACTCCATATTTACCAGCTGAAGACGCTCATCAAGAT
TGTGAAGAAAACCTACAGGGACTTTCGATTGCAGGGTGTGTTGGAAGGAACACTGAACAGTAAGACTTATGATACTGTGCACAGACGTTT
AACAGTAGAGGAGGCCACAGCCTCTGTTTCAGAAGGAGGAGGACTTCAGGGCATTACTATGAAAGACAGTGACGAAGAAGAAGAAGGCTG
ATATCACACAGCTTTGCAGAAGGAAGGAAGACCTTGATCGACATTGTTTTTTATTTTTTTAACCTTGTCCTTGTAATTACATTCATTGTT
TGTTTTGGCCAAATAAAAATGCTTGTATTTCTTTAAAAAGTAAGCCTGAATGTAGAGTAAAAGGGGAAATGCCAAGATTTTGGGGTTTTT
TTGTTTCCTTTTTTTGTTTGTTTGTTTGTTTGTTTTTTTGGAGAAGAGCATCCTCTTTTGTGTAGTTTGACCTAAAAATGAACCTTGGCT
CTGCTTGTGATCAGAACATGAACTTTTTTTTTTAAAGAAGATTTGAGCATTTTTCTGTAATCACATCAAAATGATGTTTTCTGTGTAAAG
CGAGATACATATTTCTCATAATGCAGCATTGTGAGAAGTCAGTTCGGACCACTGCACCAACACTGTCGTATCCTTGTTAAAATGGTGTGT
ACCTTACAAATTATAATTTATGTGCCAGGTTCGTTTTGTACTTAATTTGCTATTATTGTGATGTGTATAAAATCTTTAATCTTGGTTCTT
AGTACTTTGAATTGGTCTACAGGTATATTCCTGGGATGAAAGGATTGCCAAACCCAAATATAGACTAGATTATCCAATGGGTTTGTGTCT
TTGTTCCATTCTCAACATTTCTTCTTTCAACTATAAGTAATCCCCAGGTGTGGGGTAGCAAGTGTGCTTCCGTCAAGATACCATATTCTC
CTGCTCCAGTATAACAGCTTGCAGGCAATAAAAATCTATTTGCTCATAACTACTTCTGTATTTATTAGACTTATATAGAGCAAATGCAGT
AAAAGAGGTTTGCAGTGTTTCAAACATCCCAACTATCTGACTCTGTGTTTTTGTTTCTTGAGTTTTTTGTTTGTTTTGTTTGTAATATTT
TGTTTTTAATCAAATGAGTAAAAGATAGTAACACTGACTGTTCTTTGTACCTAATAGGCACATACATTGTTAAAAGAATTACTATGACAG
CATATTTCCATAGCAGAGGAAATATATATTTCATATATTATTAGTTAATATTAGTAATCAATGTTAACTAATAATTAGTAATGTTAGTAA
TATTAACTAGTAATTCACATTATTAGTGGTTCTCTCAAAATATTTTCTTGCTAGGGTTTGAGAGATAATTGTATTATGTTGCGTAAGTTC
TCTATGAATTATTTTTGTGATATTTCCCAAAACATATTGGCAGATTGTGCTACTGCATTTATTAATAAGTAATTTTTAAATGAAGGCAGT
TAATGCAGAATAAGTGGAGGTATCCCTGCATTTATGAAAACGTTTATTCTGAAACTTTAGAAATGAAACAACTTGGACCTCCAGATTCGT
TCTCCCATGGTGTAATAAGTGGTCGTTAGGTACCTAGACTAGCCTTAAAAATCTATTTAATCTACAGTTACTATTTAGCATTGTTTTGGC
TCATTTTCTGGGCCCTAGGGCTAAGATAACAAACAAGGAAATTTCTTCCTTCTTCCGGGATTAAAGACTAACTCTACCAACTCACTATCT
TTGAAAGGCAGTTTGGGAATGTTCTCCCTCCTTTTCTTCTCTATTCACACACCAAATACTATTTTCTCCAAACCCTCAAATGTCCAGTCA
TGCTATCCCAAACTCTCCAATGGCACCATCCCCAAGCTTGCTGTTCCACGACACATTGCTCTGTACTTAGTAATTACCCACCCTTCTTTT
CCTTTCAATAAAATGTCCATTTCCTTGAT

>22191_22191_9_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000394219_CADPS2_chr7_122377122_ENST00000313070_length(amino acids)=1316AA_BP=174
MRRPGDHGLQDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTK
RQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLNKQQL
QLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFREVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDA
IYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLDNADEQAAQIRRELDGRLQLADKMAKERKFPKFIAK
DMENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEIQLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCT
MEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELGRVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLA
VRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQELMQLEGYTVDYTDPHPGLQGGCMFFNAVKEGDTVI
FASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLYADRFQKHGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDS
YSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFAFCASHVHGNRPDGIGTVSVEEKERFEEIKERLS
SLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKKVVRKCLEKAALINYTRLTEYAKIEETMNQASPARKLEEILH
LAELCIEVLQQNEEHHAEAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWDSFPLFQLLNNFLRNDTLLCNGKFHKHLQEIFVPLV
VRYVDLMESSIAQSIHRGFEQETWQPVNNGSATSEDLFWKLDALQMFVFDLHWPEQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQ
KASKTTDLRIPASVCTMFNVLVDAKKQSTKLCALDGGQEVCRIFQQYHSKIDDLIDNSVKEIISLLVSKFVSVLEGVLSKLSRYDEGTFF
SSILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQDILREKVNEEMYIEKLFDQWYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKK
TYRDFRLQGVLEGTLNSKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEEG

--------------------------------------------------------------
>22191_22191_10_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000394219_CADPS2_chr7_122377122_ENST00000334010_length(transcript)=5996nt_BP=712nt
GACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCC
AGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGC
CCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGAAGTTCTACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGT
GGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTT
ATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTA
CACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCT
CAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGT
GGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAAACTCAGCACTCTTAACAA
ACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAACCCAAATTGTAGCTGACGAAGCATTTTGCAACGCAGT
TCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCCAGAATGGTACAGAGTGGAGGGTGTTCTGCTAATGACTTCAGAGAAGT
ATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCTTGAGCAAAGAGACAGTGTTGAGCTCATGGATAGCCAA
ATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAGCCAAATAGAATGGCCCTAAGTGCAGTGTCTGAACTTATTCTGAGCAA
GGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAACACCAGCTCCTTTATAATGCATGTCAGCTGGATAACGC
AGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGGCTGCAATTGGCAGATAAAATGGCAAAGGAAAGAAAATTCCCCAAATT
TATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGAATTTGCTAATGGCCAATTTGGAAAGTCTTCCAGTTTC
GAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCACAGAACTCTGCATTTTTGGACATAGGAGATGAGAATGAGATTCAGCT
GTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAGTGCAAGGCCTGAAGTCAGTTGCTCCCAATCGAATTGT
TTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGACCAGGCCGAAGCCTCAAGGCCACAATGGGGGACTCAAGGAGATTTCAC
CACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTGGAGTTCTGGCCCTGGAAGATAAAGAACTGGGAAGGGT
GATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTACACCGAATGGTAGTTCCAAAAAATAGCCAGGATTCTGACTTAAAAAT
CAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGCATAGTGGATATCTGTATGCCCTTGGACAGAAGGTTTGGAAAAGATGGAA
AAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTTGCTATGTGCAGTTATAGAGAAAAGAAGTCTGAACCACAAGAATTAAT
GCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGGGTGGTTGTATGTTCTTTAATGCTGTTAAAGAAGGAGA
TACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTATGGGTTCAAGCCATGTATAGGGCCACAGGTCAATCATATAAACCAGT
TCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAGATGCTCAGCTTTCTGAATTTACAGATGCAGATCGTTT
TCAGAAACATGGTATGGATGAGTTTATTTCTGCAAACCCCTGCAAGCTTGATCATGCCTTCCTTTTTAGAATACTCCAGAGGCAGACTTT
GGATCACAGACTGAATGATTCCTATTCTTGCTTGGGATGGTTTAGCCCTGGCCAAGTCTTTGTGTTAGATGAGTACTGTGCCCGTTATGG
TGTGAGAGGCTGTCACAGACATCTCTGCTACCTTGCAGAACTGATGGAACATTCAGAAAATGGTGCTGTCATTGACCCTACCCTGCTCCA
TTACAGCTTTGCATTCTGTGCCTCTCATGTGCACGGCAACAGGCCTGATGGAATTGGGACTGTTTCAGTGGAAGAAAAAGAAAGATTTGA
GGAGATAAAAGAGAGACTCTCTTCCCTTTTAGAAAATCAGATAAGCCATTTCAGATACTGTTTTCCCTTTGGACGACCTGAAGGTGCTCT
AAAAGCTACACTTTCATTACTTGAAAGGGTTTTAATGAAAGATATTGCCACTCCCATACCAGCAGAAGAGGTGAAGAAAGTGGTCAGAAA
ATGTCTCGAGAAAGCTGCCTTGATCAATTACACTAGACTCACAGAATATGCCAAAATAGAAGAGACCATGAACCAGGCATCTCCTGCTAG
AAAGCTGGAAGAGATTCTTCATCTGGCAGAGCTCTGCATAGAAGTCTTACAGCAGAATGAAGAGCATCATGCAGAGGCATTTGCCTGGTG
GCCTGATTTATTGGCTGAACATGCAGAGAAATTTTGGGCTTTATTTACAGTGGATATGGACACTGCACTAGAGGCTCAACCGCAAGACTC
CTGGGATAGTTTTCCTCTTTTCCAACTGCTTAATAATTTCCTCCGAAATGACACACTTTTGTGTAATGGAAAATTTCACAAACACTTGCA
AGAAATCTTTGTACCCTTGGTTGTCCGCTATGTGGATCTCATGGAGTCTTCCATCGCCCAGTCAATTCACAGAGGTTTTGAGCAGGAGAC
ATGGCAGCCTGTCAAGAATATCGCCAACAGTCTTCCCAATGTAGCTCTTCCAAAAGTTCCAAGTCTGCCTCTTAATCTTCCACAGATTCC
TAACATTTCTACTGCTTCGTGGATGCCTTCTTTATATGAGTCCACCAATGGCTCAGCAACATCAGAAGACCTTTTTTGGAAGCTTGATGC
ACTGCAAATGTTTGTCTTTGATCTGCACTGGCCAGAACAGGAATTTGCCCACCACTTAGAGCAAAGACTTAAACTAATGGCCAGTGATAT
GCTAGAGGCCTGTGTCAAAAGAACAAGAACTGCATTTGAACTCAAGCTACAAAAGGCAAGCAAAACAACTGACTTGCGCATTCCAGCTTC
CGTTTGCACTATGTTTAATGTATTAGTCGATGCCAAAAAGCAAAGCACCAAACTCTGTGCCCTGGATGGAGGACAAGAGCAACAGTACCA
TTCAAAAATAGATGATCTGATCGACAACAGTGTAAAAGAAATCATTTCACTGTTAGTTTCAAAGTTTGTTTCAGTGTTGGAAGGCGTGTT
GTCTAAGCTGTCAAGGTATGATGAAGGCACTTTCTTTTCATCCATTCTGTCATTCACTGTGAAAGCAGCTGCAAAATATGTTGATGTTCC
AAAACCAGGAATGGATCTGGCAGACACCTATATTATGTTTGTTCGGCAAAACCAAGATATTCTTCGAGAAAAGGTCAATGAGGAAATGTA
TATAGAAAAGTTATTTGATCAATGGTACAGCAGTTCCATGAAAGTCATTTGCGTGTGGTTGACTGATAGATTAGACCTCCAACTCCATAT
TTACCAGCTGAAGACGCTCATCAAGATTGTGAAGAAAACCTACAGGGACTTTCGATTGCAGGGTGTGTTGGAAGGAACACTGAACAGTAA
GACTTATGATACTGTGCACAGACGTTTAACAGTAGAGGAGGCCACAGCCTCTGTTTCAGAAGGAGGAGGACTTCAGGGCATTACTATGAA
AGACAGTGACGAAGAAGAAGAAGGCTGATATCACACAGCTTTGCAGAAGGAAGGAAGACCTTGATCGACATTGTTTTTTATTTTTTTAAC
CTTGTCCTTGTAATTACATTCATTGTTTGTTTTGGCCAAATAAAAATGCTTGTATTTCTTTAAAAAGTAAGCCTGAATGTAGAGTAAAAG
GGGAAATGCCAAGATTTTGGGGTTTTTTTGTTTCCTTTTTTTGTTTGTTTGTTTGTTTGTTTTTTTGGAGAAGAGCATCCTCTTTTGTGT
AGTTTGACCTAAAAATGAACCTTGGCTCTGCTTGTGATCAGAACATGAACTTTTTTTTTTAAAGAAGATTTGAGCATTTTTCTGTAATCA
CATCAAAATGATGTTTTCTGTGTAAAGCGAGATACATATTTCTCATAATGCAGCATTGTGAGAAGTCAGTTCGGACCACTGCACCAACAC
TGTCGTATCCTTGTTAAAATGGTGTGTACCTTACAAATTATAATTTATGTGCCAGGTTCGTTTTGTACTTAATTTGCTATTATTGTGATG
TGTATAAAATCTTTAATCTTGGTTCTTAGTACTTTGAATTGGTCTACAGGTATATTCCTGGGATGAAAGGATTGCCAAACCCAAATATAG
ACTAGATTATCCAATGGGTTTGTGTCTTTGTTCCATTCTCAACATTTCTTCTTTCAACTATAAGTAATCCCCAGGTGTGGGGTAGCAAGT
GTGCTTCCGTCAAGATACCATATTCTCCTGCTCCAGTATAACAGCTTGCAGGCAATAAAAATCTATTTGCTCATAACTACTTCTGTATTT
ATTAGACTTATATAGAGCAAATGCAGTAAAAGAGGTTTGCAGTGTTTCAAACATCCCAACTATCTGACTCTGTGTTTTTGTTTCTTGAGT
TTTTTGTTTGTTTTGTTTGTAATATTTTGTTTTTAATCAAATGAGTAAAAGATAGTAACACTGACTGTTCTTTGTACCTAATAGGCACAT
ACATTGTTAAAAGAATTACTATGACAGCATATTTCCATAGCAGAGGAAATATATATTTCATATATTATTAGTTAATATTAGTAATCAATG
TTAACTAATAATTAGTAATGTTAGTAATATTAACTAGTAATTCACATTATTAGTGGTTCTCTCAAAATATTTTCTTGCTAGGGTTTGAGA
GATAATTGTATTATGTTGCGTAAGTTCTCTATGAATTATTTTTGTGATATTTCCCAAAACATATTGGCAGATTGTGCTACTGCATTTATT
AATAAGTAATTTTTAAATGAAGGCAGTTAATGCAGAATAAGTGGAGGTATCCCTGCATTTATGAAAACGTTTATTCTGAAACTTTAGAAA
TGAAACAACTTGGACCTCCAGATTCGTTCTCCCATGGTGTAATAAGTGGTCGTTAGGTACCTAGACTAGCCTTAAAAATCTATTTAATCT
ACAGTTACTATTTAGCATTGTTTTGGCTCATTTTCTGGGCCCTAGGGCTAAGATAACAAACAAGGAAATTTCTTCCTTCTTCCGGGATTA
AAGACTAACTCTACCAACTCACTATCTTTGAAAGGCAGTTTGGGAATGTTCTCCCTCCTTTTCTTCTCTATTCACACACCAAATACTATT
TTCTCCAAACCCTCAAATGTCCAGTCATGCTATCCCAAACTCTCCAATGGCACCATCCCCAAGCTTGCTGTTCCACGACACATTGCTCTG
TACTTAGTAATTACCCACCCTTCTTTTCCTTTCAATAAAATGTCCATTTCCTTGAT

>22191_22191_10_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000394219_CADPS2_chr7_122377122_ENST00000334010_length(amino acids)=1355AA_BP=174
MRRPGDHGLQDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTK
RQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLNKQQL
QLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFREVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDA
IYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLDNADEQAAQIRRELDGRLQLADKMAKERKFPKFIAK
DMENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEIQLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCT
MEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELGRVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLA
VRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQELMQLEGYTVDYTDPHPGLQGGCMFFNAVKEGDTVI
FASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLSEFTDADRFQKHGMDEFISANPCKLDHAFLFRILQRQTLDHR
LNDSYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFAFCASHVHGNRPDGIGTVSVEEKERFEEIK
ERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKKVVRKCLEKAALINYTRLTEYAKIEETMNQASPARKLE
EILHLAELCIEVLQQNEEHHAEAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWDSFPLFQLLNNFLRNDTLLCNGKFHKHLQEIF
VPLVVRYVDLMESSIAQSIHRGFEQETWQPVKNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYESTNGSATSEDLFWKLDALQM
FVFDLHWPEQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKASKTTDLRIPASVCTMFNVLVDAKKQSTKLCALDGGQEQQYHSKI
DDLIDNSVKEIISLLVSKFVSVLEGVLSKLSRYDEGTFFSSILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQDILREKVNEEMYIEK
LFDQWYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTYRDFRLQGVLEGTLNSKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSD
EEEEG

--------------------------------------------------------------
>22191_22191_11_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000394219_CADPS2_chr7_122377122_ENST00000412584_length(transcript)=4560nt_BP=712nt
GACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCC
AGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGC
CCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGAAGTTCTACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGT
GGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTT
ATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTA
CACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCT
CAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGT
GGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAAACTCAGCACTCTTAACAA
ACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAACCCAAATTGTAGCTGACGAAGCATTTTGCAACGCAGT
TCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCCAGAATGGTACAGAGTGGAGGGTGTTCTGCTAATGACTTCAGAGAAGT
ATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCTTGAGCAAAGAGACAGTGTTGAGCTCATGGATAGCCAA
ATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAGCCAAATAGAATGGCCCTAAGTGCAGTGTCTGAACTTATTCTGAGCAA
GGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAACACCAGCTCCTTTATAATGCATGTCAGCTGGATAACGC
AGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGGCTGCAATTGGCAGATAAAATGGCAAAGGAAAGAAAATTCCCCAAATT
TATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGAATTTGCTAATGGCCAATTTGGAAAGTCTTCCAGTTTC
GAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCACAGAACTCTGCATTTTTGGACATAGGAGATGAGAATGAGATTCAGCT
GTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAGTGCAAGGCCTGAAGTCAGTTGCTCCCAATCGAATTGT
TTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGACCAGGCCGAAGCCTCAAGGCCACAATGGGGGACTCAAGGAGATTTCAC
CACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTGGAGTTCTGGCCCTGGAAGATAAAGAACTGGGAAGGGT
GATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTACACCGAATGGTAGTTCCAAAAAATAGCCAGGATTCTGACTTAAAAAT
CAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGCATAGTGGATATCTGTATGCCCTTGGACAGAAGGTTTGGAAAAGATGGAA
AAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTTGCTATGTGCAGTTATAGAGAAAAGAAGTCTGAACCACAAGAATTAAT
GCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGGGTGGTTGTATGTTCTTTAATGCTGTTAAAGAAGGAGA
TACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTATGGGTTCAAGCCATGTATAGGGCCACAGGTCAATCATATAAACCAGT
TCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAGATGCTCAGCTTTATGCAGATCGTTTTCAGAAACATGG
TATGGATGAGTTTATTTCTGCAAACCCCTGCAAGCTTGATCATGCCTTCCTTTTTAGAATACTCCAGAGGCAGACTTTGGATCACAGACT
GAATGATTCCTATTCTTGCTTGGGATGGTTTAGCCCTGGCCAAGTCTTTGTGTTAGATGAGTACTGTGCCCGTTATGGTGTGAGAGGCTG
TCACAGACATCTCTGCTACCTTGCAGAACTGATGGAACATTCAGAAAATGGTGCTGTCATTGACCCTACCCTGCTCCATTACAGCTTTGC
ATTCTGTGCCTCTCATGTGCACGGCAACAGGCCTGATGGAATTGGGACTGTTTCAGTGGAAGAAAAAGAAAGATTTGAGGAGATAAAAGA
GAGACTCTCTTCCCTTTTAGAAAATCAGATAAGCCATTTCAGATACTGTTTTCCCTTTGGACGACCTGAAGGTGCTCTAAAAGCTACACT
TTCATTACTTGAAAGGGTTTTAATGAAAGATATTGCCACTCCCATACCAGCAGAAGAGGTGAAGAAAGTGGTCAGAAAATGTCTCGAGAA
AGCTGCCTTGATCAATTACACTAGACTCACAGAATATGCCAAAATAGAAGAGACCATGAACCAGGCATCTCCTGCTAGAAAGCTGGAAGA
GATTCTTCATCTGGCAGAGCTCTGCATAGAAGTCTTACAGCAGAATGAAGAGCATCATGCAGAGGCATTTGCCTGGTGGCCTGATTTATT
GGCTGAACATGCAGAGAAATTTTGGGCTTTATTTACAGTGGATATGGACACTGCACTAGAGGCTCAACCGCAAGACTCCTGGGATAGTTT
TCCTCTTTTCCAACTGCTTAATAATTTCCTCCGAAATGACACACTTTTGTGTAATGGAAAATTTCACAAACACTTGCAAGAAATCTTTGT
ACCCTTGGTTGTCCGCTATGTGGATCTCATGGAGTCTTCCATCGCCCAGTCAATTCACAGAGGTTTTGAGCAGGAGACATGGCAGCCTGT
CAACAATGGCTCAGCAACATCAGAAGACCTTTTTTGGAAGCTTGATGCACTGCAAATGTTTGTCTTTGATCTGCACTGGCCAGAACAGGA
ATTTGCCCACCACTTAGAGCAAAGACTTAAACTAATGGCCAGTGATATGCTAGAGGCCTGTGTCAAAAGAACAAGAACTGCATTTGAACT
CAAGCTACAAAAGGCAAGCAAAACAACTGACTTGCGCATTCCAGCTTCCGTTTGCACTATGTTTAATGTATTAGTCGATGCCAAAAAGCA
AAGCACCAAACTCTGTGCCCTGGATGGAGGACAAGAGTTTGGTAGTCAATGGCAACAGTACCATTCAAAAATAGATGATCTGATCGACAA
CAGTGTAAAAGAAATCATTTCACTGTTAGTTTCAAAGTTTGTTTCAGTGTTGGAAGGCGTGTTGTCTAAGCTGTCAAGGTATGATGAAGG
CACTTTCTTTTCATCCATTCTGTCATTCACTGTGAAAGCAGCTGCAAAATATGTTGATGTTCCAAAACCAGGAATGGATCTGGCAGACAC
CTATATTATGTTTGTTCGGCAAAACCAAGATATTCTTCGAGAAAAGGTCAATGAGGAAATGTATATAGAAAAGTTATTTGATCAATGGTA
CAGCAGTTCCATGAAAGTCATTTGCGTGTGGTTGACTGATAGATTAGACCTCCAACTCCATATTTACCAGCTGAAGACGCTCATCAAGAT
TGTGAAGAAAACCTACAGGGACTTTCGATTGCAGGGTGTGTTGGAAGGAACACTGAACAGTAAGACTTATGATACTGTGCACAGACGTTT
AACAGTAGAGGAGGCCACAGCCTCTGTTTCAGAAGGAGGAGGACTTCAGGGCATTACTATGAAAGACAGTGACGAAGAAGAAGAAGGCTG
ATATCACACAGCTTTGCAGAAGGAAGGAAGACCTTGATCGACATTGTTTTTTATTTTTTTAACCTTGTCCTTGTAATTACATTCATTGTT
TGTTTTGGCCAAATAAAAATGCTTGTATTTCTTTAAAAAGTAAGCCTGAATGTAGAGTAAAAGGGGAAATGCCAAGATTTTGGGGTTTTT
TTGTTTCCTTTTTTTGTTTGTTTGTTTGTTTGTTTTTTTGGAGAAGAGCATCCTCTTTTGTGTAGTTTGACCTAAAAATGAACCTTGGCT
CTGCTTGTGATCAGAACATGAACTTTTTTTTTTAAAGAAGATTTGAGCATTTTTCTGTAATCACATCAAAATGATGTTTTCTGTGTAAAG
CGAGATACATATTTCTCATAATGCAGCATTGTGAGAAGTCAGTTCGGACCACTGCACCAA

>22191_22191_11_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000394219_CADPS2_chr7_122377122_ENST00000412584_length(amino acids)=1316AA_BP=174
MRRPGDHGLQDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTK
RQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLNKQQL
QLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFREVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDA
IYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLDNADEQAAQIRRELDGRLQLADKMAKERKFPKFIAK
DMENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEIQLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCT
MEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELGRVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLA
VRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQELMQLEGYTVDYTDPHPGLQGGCMFFNAVKEGDTVI
FASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLYADRFQKHGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDS
YSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFAFCASHVHGNRPDGIGTVSVEEKERFEEIKERLS
SLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKKVVRKCLEKAALINYTRLTEYAKIEETMNQASPARKLEEILH
LAELCIEVLQQNEEHHAEAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWDSFPLFQLLNNFLRNDTLLCNGKFHKHLQEIFVPLV
VRYVDLMESSIAQSIHRGFEQETWQPVNNGSATSEDLFWKLDALQMFVFDLHWPEQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQ
KASKTTDLRIPASVCTMFNVLVDAKKQSTKLCALDGGQEFGSQWQQYHSKIDDLIDNSVKEIISLLVSKFVSVLEGVLSKLSRYDEGTFF
SSILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQDILREKVNEEMYIEKLFDQWYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKK
TYRDFRLQGVLEGTLNSKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEEG

--------------------------------------------------------------
>22191_22191_12_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000394219_CADPS2_chr7_122377122_ENST00000449022_length(transcript)=4426nt_BP=712nt
GACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCC
AGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGC
CCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGAAGTTCTACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGT
GGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTT
ATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGCTATCTCCCCTGGTTCGAGGTATTTTATAAGCTGCTTAACATCCTGGCAGATTA
CACGACAAAAAGACAGGAAAATCAGTGGAATGAGCTTCTTGAAACTCTGCACAAACTTCCCATCCCTGACCCAGGAGTGTCTGTCCATCT
CAGCGTGCATTCTTATTTTACTGTGCCTGATACCAGAGAACTTCCCAGCATACCTGAGAATAGAAATCTGACAGAATATTTTGTGGCTGT
GGATGTTAACAACATGTTGCATCTGTACGCCAGTATGCTGTACGAACGCCGGATACTCATCATTTGCAGCAAACTCAGCACTCTTAACAA
ACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAACCCAAATTGTAGCTGACGAAGCATTTTGCAACGCAGT
TCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCCAGAATGGTACAGAGTGGAGGGTGTTCTGCTAATGACTTCAGAGAAGT
ATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCTTGAGCAAAGAGACAGTGTTGAGCTCATGGATAGCCAA
ATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAGCCAAATAGAATGGCCCTAAGTGCAGTGTCTGAACTTATTCTGAGCAA
GGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAACACCAGCTCCTTTATAATGCATGTCAGCTGGATAACGC
AGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGGCTGCAATTGGCAGATAAAATGGCAAAGGAAAGAAAATTCCCCAAATT
TATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGAATTTGCTAATGGCCAATTTGGAAAGTCTTCCAGTTTC
GAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCACAGAACTCTGCATTTTTGGACATAGGAGATGAGAATGAGATTCAGCT
GTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAGTGCAAGGCCTGAAGTCAGTTGCTCCCAATCGAATTGT
TTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGACCAGGCCGAAGCCTCAAGGCCACAATGGGGGACTCAAGGAGATTTCAC
CACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTGGAGTTCTGGCCCTGGAAGATAAAGAACTGGGAAGGGT
GATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTACACCGAATGGTAGTTCCAAAAAATAGCCAGGATTCTGACTTAAAAAT
CAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGCATAGTGGATATCTGTATGCCCTTGGACAGAAGGTTTGGAAAAGATGGAA
AAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTTGCTATGTGCAGTTATAGAGAAAAGAAGTCTGAACCACAAGAATTAAT
GCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGGGTGGTTGTATGTTCTTTAATGCTGTTAAAGAAGGAGA
TACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTATGGGTTCAAGCCATGTATAGGGCCACAGGTCAATCATATAAACCAGT
TCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAGATGCTCAGCTTTCTGGTAAAGATGCAGATCGTTTTCA
GAAACATGGTATGGATGAGTTTATTTCTGCAAACCCCTGCAAGCTTGATCATGCCTTCCTTTTTAGAATACTCCAGAGGCAGACTTTGGA
TCACAGACTGAATGATTCCTATTCTTGCTTGGGATGGTTTAGCCCTGGCCAAGTCTTTGTGTTAGATGAGTACTGTGCCCGTTATGGTGT
GAGAGGCTGTCACAGACATCTCTGCTACCTTGCAGAACTGATGGAACATTCAGAAAATGGTGCTGTCATTGACCCTACCCTGCTCCATTA
CAGCTTTGCATTCTGTGCCTCTCATGTGCACGGCAACAGGCCTGATGGAATTGGGACTGTTTCAGTGGAAGAAAAAGAAAGATTTGAGGA
GATAAAAGAGAGACTCTCTTCCCTTTTAGAAAATCAGATAAGCCATTTCAGATACTGTTTTCCCTTTGGACGACCTGAAGGTGCTCTAAA
AGCTACACTTTCATTACTTGAAAGGGTTTTAATGAAAGATATTGCCACTCCCATACCAGCAGAAGAGGTGAAGAAAGTGGTCAGAAAATG
TCTCGAGAAAGCTGCCTTGATCAATTACACTAGACTCACAGAATATGCCAAAATAGAAGAGACCATGAACCAGGCATCTCCTGCTAGAAA
GCTGGAAGAGATTCTTCATCTGGCAGAGCTCTGCATAGAAGTCTTACAGCAGAATGAAGAGCATCATGCAGAGGGAAGAGAGGCATTTGC
CTGGTGGCCTGATTTATTGGCTGAACATGCAGAGAAATTTTGGGCTTTATTTACAGTGGATATGGACACTGCACTAGAGGCTCAACCGCA
AGACTCCTGGGATAGTTTTCCTCTTTTCCAACTGCTTAATAATTTCCTCCGAAATGACACACTTTTGTGTAATGGAAAATTTCACAAACA
CTTGCAAGAAATCTTTGTACCCTTGGTTGTCCGCTATGTGGATCTCATGGAGTCTTCCATCGCCCAGTCAATTCACAGAGGTTTTGAGCA
GGAGACATGGCAGCCTGTCAAGAATATCGCCAACAGTCTTCCCAATGTAGCTCTTCCAAAAGTTCCAAGTCTGCCTCTTAATCTTCCACA
GATTCCTAACATTTCTACTGCTTCGTGGATGCCTTCTTTATATGAGTCCACCAATGGCTCAGCAACATCAGAAGACCTTTTTTGGAAGCT
TGATGCACTGCAAATGTTTGTCTTTGATCTGCACTGGCCAGAACAGGAATTTGCCCACCACTTAGAGCAAAGACTTAAACTAATGGCCAG
TGATATGCTAGAGGCCTGTGTCAAAAGAACAAGAACTGCATTTGAACTCAAGCTACAAAAGGCAAGCAAAACAACTGACTTGCGCATTCC
AGCTTCCGTTTGCACTATGTTTAATGTATTAGTCGATGCCAAAAAGCAAAGCACCAAACTCTGTGCCCTGGATGGAGGACAAGAGCAACA
GTACCATTCAAAAATAGATGATCTGATCGACAACAGTGTAAAAGAAATCATTTCACTGTTAGTTTCAAAGTTTGTTTCAGTGTTGGAAGG
CGTGTTGTCTAAGCTGTCAAGGTATGATGAAGGCACTTTCTTTTCATCCATTCTGTCATTCACTGTGAAAGCAGCTGCAAAATATGTTGA
TGTTCCAAAACCAGGAATGGATCTGGCAGACACCTATATTATGTTTGTTCGGCAAAACCAAGATATTCTTCGAGAAAAGGTCAATGAGGA
AATGTATATAGAAAAGTTATTTGATCAATGGTACAGCAGTTCCATGAAAGTCATTTGCGTGTGGTTGACTGATAGATTAGACCTCCAACT
CCATATTTACCAGCTGAAGACGCTCATCAAGATTGTGAAGAAAACCTACAGGGACTTTCGATTGCAGGGTGTGTTGGAAGGAACACTGAA
CAGTAAGACTTATGATACTGTGCACAGACGTTTAACAGTAGAGGAGGCCACAGCCTCTGTTTCAGAAGGAGGAGGACTTCAGGGCATTAC
TATGAAAGACAGTGACGAAGAAGAAGAAGGCTGATATCACACAGCTTTGCAGAAGGAAGGAAGACCTTGATCGACATTGTTTTTTATTTT
TTTAACCTTGTCCTTGTAATTACATTCATTGTTTGTTTTGGCCAAATAAAAATGCTTGTATTTCTTTAAAAAGTAAGCCTGAATGTAGAG
TAAAAGGGGAAATGCC

>22191_22191_12_DENND1A-CADPS2_DENND1A_chr9_126414292_ENST00000394219_CADPS2_chr7_122377122_ENST00000449022_length(amino acids)=1357AA_BP=174
MRRPGDHGLQDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTK
RQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLNKQQL
QLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFREVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDA
IYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLDNADEQAAQIRRELDGRLQLADKMAKERKFPKFIAK
DMENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEIQLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCT
MEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELGRVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLA
VRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQELMQLEGYTVDYTDPHPGLQGGCMFFNAVKEGDTVI
FASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLSGKDADRFQKHGMDEFISANPCKLDHAFLFRILQRQTLDHRL
NDSYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFAFCASHVHGNRPDGIGTVSVEEKERFEEIKE
RLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKKVVRKCLEKAALINYTRLTEYAKIEETMNQASPARKLEE
ILHLAELCIEVLQQNEEHHAEGREAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWDSFPLFQLLNNFLRNDTLLCNGKFHKHLQE
IFVPLVVRYVDLMESSIAQSIHRGFEQETWQPVKNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYESTNGSATSEDLFWKLDAL
QMFVFDLHWPEQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKASKTTDLRIPASVCTMFNVLVDAKKQSTKLCALDGGQEQQYHS
KIDDLIDNSVKEIISLLVSKFVSVLEGVLSKLSRYDEGTFFSSILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQDILREKVNEEMYI
EKLFDQWYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTYRDFRLQGVLEGTLNSKTYDTVHRRLTVEEATASVSEGGGLQGITMKD
SDEEEEG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DENND1A-CADPS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCADPS2chr9:126414292chr7:122377122ENST00000412584028755_1074113.01256.0DRD2
TgeneCADPS2chr9:126414292chr7:122377122ENST00000449022030755_1074113.01297.0DRD2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DENND1A-CADPS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DENND1A-CADPS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0004352Autistic Disorder1CTD_human
TgeneC0008370Cholestasis1CTD_human
TgeneC0013146Drug abuse1CTD_human
TgeneC0013170Drug habituation1CTD_human
TgeneC0013222Drug Use Disorders1CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0038580Substance Dependence1CTD_human
TgeneC0038586Substance Use Disorders1CTD_human
TgeneC0236969Substance-Related Disorders1CTD_human
TgeneC0740858Substance abuse problem1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC1510472Drug Dependence1CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneC4316881Prescription Drug Abuse1CTD_human